| US 7,365,079 B2 | ||
| Azole derivatives | ||
| Norikazu Otake, Tsukuba (Japan); Yuji Haga, Tsukuba (Japan); Makoto Jitsuoka, Tsukuba (Japan); and Akio Kanatani, Tsukuba (Japan) | ||
| Assigned to Banyu Pharmaceutical Co., Ltd., Tokyo (Japan) | ||
| Appl. No. 10/536,360 PCT Filed Nov. 25, 2003, PCT No. PCT/JP03/15018 § 371(c)(1), (2), (4) Date Sep. 09, 2005, PCT Pub. No. WO2004/050652, PCT Pub. Date Jun. 17, 2004. |
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| Claims priority of application No. 2002-346997 (JP), filed on Nov. 29, 2002. | ||
| Prior Publication US 2006/0111380 A1, May 25, 2006 | ||
| Int. Cl. A61K 31/4355 (2006.01); C07D 471/04 (2006.01) | ||
| U.S. Cl. 514—278 [514/302; 546/15; 546/116] | 21 Claims |
1. A compound of the formula (I):
 Ar1 is aryl or heteroaryl, any of which is optionally substituted by a substituent selected from the group consisting of halogen,
nitro, oxo, hydroxy, lower alkyl, halo-lower alkyl, hydroxy-lower alkyl, cyclo-lower alkyl, lower alkenyl, lower alkoxy, halo-lower
alkoxy, lower alkylthio, lower alkylsulfonyl, carboxyl, lower alkanoyl, lower alkoxycarbonyl, lower alkanoylamino and -Q2-Ar2;
Ar2 is aryl or heteroaryl, any of which is optionally substituted by a substituent selected from the group consisting of halogen,
cyano, lower alkyl, halo-lower alkyl, hydroxy-lower alkyl, hydroxy, lower alkoxy, halo-lower alkoxy, lower alkylamino, di-lower
alkylamino, lower alkanoyl and aryl;
Q1 and Q2 are independently a single bond, oxygen atom, carbonyl or —N(R3)—;
R1 and R2 are independently hydrogen atom or lower alkyl, or R1 and R2, taken together, form lower alkylene which may be interrupted by oxygen atom, sulfur atom or imino;
R3 is hydrogen atom or lower alkyl;
T, V and W are independently methine, U is nitrogen atom, said methine being optionally substituted by a substituent selected
from the group consisting of halogen, lower alkyl, halo-lower alkyl, hydroxy, lower alkoxy and halo-lower alkoxy; and
X is methine, or a salt or ester thereof.
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