New York

Clinical Research Resources Links

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The Feinstein Institute for Medical Research (New York City)
Mount Sinai School of Medicine (New York City)
New York University (New York City)
State University of New York, Stony Brook

The Feinstein Institute for Medical Research

General Clinical Research Center
350 Community Drive
Manhasset, NY 11030

Web site: http://www.nslij.com/body.cfm?id=2737&oTopID=2581&PLinkID=5096 external link, opens in new window

Grant No. M01 RR018535

Special Assays, Services, or Tests

Biorepository core and tissue donation program: Tissues: site initiation (find a source for samples), collection; access to existing samples; Biorepository (stores biological fluids long-term or short-term): plasma, serum, DNA Imaging core: PET scans, MRI scans, fMRI

Molecular biology and immunology core: DNA synthesis of custom oligonucleotides <120 bp in length; standard oligonucleotides; single fluorescently labeled oligonucleotide; double fluorescently labeled oligonucleotide; DNA sequencing; protein sequencing; protein synthesis, 15-20 amino acid residue oligomers; real-time or quantitative PCR; confocal microscope; Hewlett-Packard matrix-assisted laser desorption ionization-time of flight (MALDI-TOF) mass spectrophotometer; gas chromatograph/mass spectrophotometer; ProteinChip protein analysis system; Sorvall centrifuges, scintillation counter; Bio-Rad gel system, lyophilizer, Shimadzu biospectrophotometer, Savant; automated speed-vac system, dark room, radioactive fume hood; flow cytometry; cytokine ELISA; RNA i solation; silver nitrate immunoperoxidase (SNIP) analysis

Major Areas of Investigation

Cardiology: Cardiac surgery; thyroid hormone therapy.

Endocrinology: Diabetes.

Gastroenterology: Inflammatory bowel disease.

Hematology: Diamond-Blackfan.

Immunology: Chronic lymphomic leukemia; rheumatoid arthritis.

Molecular Genetics: Rheumatoid arthritis; systemic lupus erythematosus; cancer.

Nephrology: Congenital uropathies; diarrhea-related hemolytic uremic syndrome (D-HUS).

Neuropsychiatry: Parkinson's disease; Alzheimer's disease.

Psychiatry: Schizophrenia; depression; post-traumatic disorder; bipolar disorder; autism; obsessive compulsive disorder.

Sepsis: Cytokine responses; HMGB1; cholinergic anti-inflammatory pathway.

Urology: Cystitis; urinary incontinence.

Vascular Disease: Abdominal aortic aneurysm; peripheral vascular disease; carotid endardectomy.

Contact Information

For information about this GCRC and how to access its resources, please contact:

Administrative Manager
Kathleen Mann-Finnerty, R.N., M.A.
516-562-1045; Fax: 516-562-1006
E-mail: kmann@nshs.edu

Program Director
David Eidelberg, M.D.
516-562-2498; Fax: 516-562-1008
E-mail: david1@nshs.edu

Principal Investigator
Kevin J. Tracey, M.D.
516-562-2813; Fax: 516-562-2356
E-mail: kjtracey@nshs.edu

Associate Program Director
Irwin Klein, M.D.
516-562-4368; Fax: 718-437-7717
E-mail: iklein@nshs.edu

Associate Program Director
Howard Trachtman, M.D.
718-470-3491; Fax: 718-470-0887
E-mail: htrachtm@lij.edu

Associate Program Director
Andrew Feigin, M.D.
516-869-9527; Fax: 516-869-9535
E-mail: asfeigin@aol.com

Assistant Program Director
Philip Szeszko, Ph.D.
718-470-8489; Fax: 718-343-1659
E-mail: szeszko@lij.edu

Assistant Program Director
Bettie Steinberg, Ph.D.
516-562-1159; Fax: 718-343-1659
E-mail: bsteinbe@lij.edu

Research Subject Advocate
Ruth Morgan, D.C.
516-562-4874; Fax: 516-562-1006
E-mail: rmorgan1@nshs.edu

GCRC Advisory Committee Chairperson
Vivian Kafantaris, M.D.
718-470-8556; Fax: 718-343-1659
E-mail: vkafanta@lij.edu

Nurse Manager
Julie Martusciello, R.N., B.S.N.
516-562-1021; Fax: 516-562-1006
E-mail: jmartusc@nshs.edu

Biostatistics Director
Martin L. Lesser, Ph.D.
516-240-8300; Fax: 516-240-8344
E-mail: marty@nshs.edu

Informatics Manager
James Tsang, M.P.H.
516-240-8300; Fax: 516-240-8344
E-mail: jtsang@nshs.edu

Molecular Biology and Immunology Core Director
Margot Puerta, M.S.
516-562-1129; Fax: 516-562-1022
E-mail: mpuerta@nshs.edu

Biorepository and Tissue Donation Program Director
Peter Gregersen, M.D.
516-562-1542; Fax: 516-562-1153
E-mail: peterg@nshs.edu

Mount Sinai School of Medicine

General Clinical Research Center
Box 1027
Mount Sinai School of Medicine
One Gustave L. Levy Place
New York, NY 10029

Web site: www.mssm.edu/gcrc/index.shtml external link, opens in new window

Grant No. M01 RR00071

Special Assays, Services, or Tests

DNA facility: Molecular mutation identification by DNA sequence analysis; direct mutation detection; polymerase chain reaction amplification; restriction enzyme digestion, allele-specific oligonucleotide hybridization; linkage analysis; Southern hybridization analysis; polymorphism analysis; DNA isolation and banking; establishment of immortalized cell lines

Major Areas of Investigation

Endocrinology: Role of insulin in modulating responsiveness to androgens in ovarian dysfunction; evaluation of ethnic factors influencing bone mass in female population.

Genetic Diseases: Molecular basis of phenotypic variation in Fabry's and Gaucher's diseases; therapy of inborn errors of metabolism (including enzyme deficiencies, amino acid disorders, lipid storage diseases) by dietary, cofactor, transplantation, enzyme replacement, and recombinant DNA approaches; natural history of inborn errors of metabolism and other genetic diseases (such as Niemann-Pick disease).

Geriatrics: Drug metabolism; endogenous formation of advanced glycation end products (AGEs) in diabetes.

Hematology: Growth and development in children with hemophilia; beta-globin disorders.

Internal Medicine: Determinants of vasodilator response in heart failure; effect of lowering cholesterol on thrombotic markers; thrombus formation; lead mobilization during pregnancy and lactation in young urban women.

Neurology: Therapy of parkinsonism, myoclonus, dysautonomia, and seizure disorders; HIV dementia; peptide-T in HIV-positive patients.

Pediatrics: Immunopathogenic mechanisms of food hypersensitivity in children with atopic dermatitis; cow milk-induced hypersensitivities; peanut hypersensitivity.

Psychiatry: Role of glucose metabolism, cholinergic neurotransmitters in memory function in Alzheimer's disease; biochemical alterations in schizophrenia and schizophrenia spectrum disorders; post-traumatic stress disorder; major depression; panic and generalized anxiety disorders; autism and autistic spectrum disorders; obsessive-compulsive, dissociative, and impulse control disorders.

Contact Information

For information about this GCRC and how to access its resources, please contact:

Administrative Director
Vivian Mitropoulou, M.A.
212-241-6046; Fax: 212-348-5811
E-mail: vivian.mitropoulou@mssm.edu

Program Director
Hugh Sampson, M.D.
212-241-7816; Fax: 212-426-1902
E-mail: hugh.sampson@mssm.edu

Principal Investigator
Dennis Charney, M.D.
212-241-5674; Fax: 212-410-6111
E-mail: dennis.charney@mssm.edu

Associate Program Director
Ilene Wilets, Ph.D.
212-241-2714; Fax: 212-348-5811
E-mail: ilene.wilets@mssm.edu

Associate Program Director
Margaret M. McGovern, M.D., Ph.D.
212-241-9234; Fax: 212-860-3316
E-mail: margaret.mcgovern@mssm.edu

Associate Program Director
Maria Keller, M.D.
212-241-5890; Fax: 212-348-5811
E-mail: maria.keller@mssm.edu

GCRC Advisory Committee Chairperson
Mary Klotman, M.D.
212-241-2950; Fax: 212-534-3240
E-mail: mary.klotman@mssm.edu

Nursing Director
Cecilia Alvarez, R.N., M.S.
212-241-6041; Fax: 212-348-5811
E-mail: cecilia.alvarez@mssm.edu

Core Laboratory Director
George A. Diaz, M.D., Ph.D.
212-659-6790; Fax: 212-849-2508
E-mail: george.diaz@mssm.edu

Research Dietician
Shideh Mofidi, M.S., R.D.
212-241-6045; Fax: 212-348-5811
E-mail: shideh.mofidi@mssm.edu

Informatics Director
Michael Lipkowitz
212-241-2264; Fax: 212-987-0389
E-mail: mike.lipkowitz@mssm.edu

Biostatistician
Sylvan Wallenstein, Ph.D.
212-241-1526; Fax: 212-860-4630
E-mail: sylvan.wallenstein@mssm.edu

Computer Systems and Informatics Manager
Angela Reznick
212-241-1804; Fax: 212-348-5811
E-mail: angela.reznick@mssm.edu

New York University

General Clinical Research Center
New Bellevue Building, 8E36
New York University Medical Center
550 First Avenue
New York, NY 10016

Web site: http://gcrc.med.nyu.edu external link, opens in new window

Grant No. M01 RR00096

Major Areas of Investigation

Aging: Longitudinal studies of aging and dementia; pharmacological therapies of Alzheimer's disease; effects of glucose and cortisol on aging.

AIDS, Adult: Highly active antiretroviral therapy (HAART) for adults; impact of discontinuing therapy for opportunistic infections in subjects who have responded to HAART; cytokine administration with HAART; clinical studies for the treatment of cervical dysplasia, oral candidiasis, cytomegalovirus retinitis and HIV-associated wasting; multiple trials with new antiretroviral therapies; immunomodulation and immune restoration with drugs and cytokines; longitudinal study of AIDS.

AIDS, Pediatric: Highly active antiretroviral therapy (HAART) for children; immunological and pharmacological studies to understand and treat maternal-fetal transmission of HIV and AIDS; effects of cytokines on HAART in children; recombinant growth hormone in HIV-associated growth failure; pathogenesis of HIV infection and the biology of hepatitis C infection in HIV-infected mothers and children.

Endocrinology: New approaches to the treatment of growth hormone deficiency; new agents in the treatment of non-insulin-dependent diabetes mellitus.

Genitourinary Disorders: Medical therapy for benign prostatic hyperplasia; chemoprevention of prostate cancer.

Imaging: Preoperative mapping of seizures using magnetoencephalogram (MEG); MEG recordings of normal, blind, and dyslexic subjects and patients with neurological and psychiatric disorders.

Neurology: Diagnosis and treatment of Gaucher's disease.

Obstetrics and Gynecology: Prediction of preterm labor using sonogram and fibronectin levels; vasoactive mediators in the pathogenesis of preeclampsia; novel therapies for gynecological malignancies.

Oncology: Novel chemotherapy regimens with and without radiation therapy for solid tumors; cell-mediated immunity for metastatic malignant melanoma; prevention of breast cancer and novel strategies for treatment of breast cancer using neoadjuvant and antiepidermal therapies; intraperitoneal infusion of chemotherapeutic agents for gastric and ovarian cancer; protein kinase C modulators; phenethyl isothiocyanate (PEITC) as a chemopreventive agent; thalidomide for unresectable hepatocellular carcinoma; other new approaches for treatment of solid tumors.

Otolaryngology: Novel monoclonal antibody therapy in head and neck cancer; therapeutic approaches to autoimmune inner-ear disease; evaluation of facial nerve dysfunction following acoustic neuroma surgery.

Pediatric Oncology: Reducing cardiac dysfunction after chemotherapy.

Psychiatry: New therapies for schizophrenia and cocaine abuse; physiologic correlates of addiction.

Pulmonary Diseases: Bronchoalveolar lavage in normal volunteers, asbestos-exposed workers, and pulmonary fibrosis patients; new drug therapies for multidrug-resistant tuberculosis, interstitial fibrosis, and pulmonary aspergilloma; mechanisms of host response to tuberculosis/AIDS, including immunology, cytokine expression, and transcription factor regulation; novel approaches in treatment of asthma; gene therapy for lung cancer and Pompe's disease; mechanisms of p53 cell cycle deregulation in lung cancer; NYU Biomarker Clinical and Epidemiologic Center for Lung Cancer; chemoprevention of lung cancer.

Rheumatology: Pharmacologic mechanisms of antirheumatic agents; safety of estrogens in systemic lupus erythematosus (SLE); immunological study of serologically active stable SLE.

Sleep Studies: Diagnosis and epidemiology of upper airway resistance; mechanism and treatment of obstructive sleep apnea syndrome; understanding carbon dioxide balance during sleep; evaluation of disordered breathing in select patient.

Contact Information

For information about this GCRC and how to access its resources, please contact:

Administrative Director
Deborah Chavis-Keeling
212-263-6410; Fax: 212-263-8501
E-mail: deborah.keeling@med.nyu.edu

Program Director
Bruce Cronstein, M.D.
212-263-6404; Fax: 212-263-1048
E-mail: bruce.cronstein@med.nyu.edu

Principal Investigator
Robert I. Grossman, M.D.
212-263-3269; Fax: 212-263-8137
E-mail: robert.grossman@med.nyu.edu

Associate Program Director
William Borkowsky, M.D.
212-263-6513; Fax: 212-263-7806
E-mail: borkowsky@med.nyu.edu

Associate Program Director for Informatics
Ross Smith, M.D., Ph.D.
212-263-5356; Fax: 212-263-7135
E-mail: phillip.smith@med.nyu.edu

Assistant Program Director
Michael Weiden, M.D.
212-263-7889; Fax: 212-263-8501
E-mail: michael.weiden@med.nyu.edu

Nurse Manager
Eleanor DeCandia, R.N., M.A., C.C.R.C.
212-263-6411; Fax: 212-263-8501
E-mail: eleanor.decandia@med.nyu.edu

Research Subject Advocate
Eric Leibert, M.D.
212-263-2623; Fax: 212-263-8442
E-mail: eric.leibert@med.nyu.edu

GCRC Advisory Committee Co-Chairperson
Wade P. Parks, Ph.D., M.D.
212-263-6421; Fax: 212-263-4147
E-mail: wade.parks@med.nyu.edu

GCRC Advisory Committee Co-Chairperson
Martin J. Blaser, M.D.
212-263-6394; Fax: 212-263-3969
E-mail: martin.blaser@med.nyu.edu

Core Laboratory Director
Frank Martiniuk, Ph.D.
212-263-7770; Fax: 212-263-8501
E-mail: frank.martiniuk@med.nyu.edu

Informatics Core Manager
Steven Aponte, B.A.
212-263-7492; Fax: 212-263-8501
E-mail: steven.aponte@med.nyu.edu

Director of Biostatistics
Judith Goldberg, Sc.D.
212-263-6879; Fax: 212-263-8570
E-mail: jd.goldberg@med.nyu.edu

Biostatistician
Ilana Belitskaya, Ph.D.
212-263-6879; Fax: 212-263-8570
E-mail: ilana.belitskaya@med.nyu.edu

State University of New York, Stony Brook

General Clinical Research Center
University Hospital, 12 South
Stony Brook, NY 11794

Grant No. M01 RR10710

Special Assays, Services, or Tests

Biostatistics and informatics

Gas chromatography/mass spectrometry is available to measure enrichment of stable isotopes in physiological samples derived from metabolic tracer studies

Genetics core laboratory offers genetic testing for well-characterized human genetic disorders. Quality assurance, sample handling and processing, and compliance issues have been established. Isolation and storage of DNA from patient peripheral blood leukocytes; storage and tracking of patient material; assistance with techniques of genetic mutation identification (oligonucleotide primer generation); Epstein-Barr virus (EBV) transformation of lymphocytes for rare human disorders, storage of lymphocytes; DNA sequence analysis

Immuno- and radiometric assays for insulin-like growth factors I and II; insulin-like growth factor binding protein_{1, 2, 3} ; growth hormone, prolactin, catecholamines, dopamine

Outreach program to recruit minorities and women

Major Areas of Investigation

Aging: Regulation of muscle metabolism; effects of GH on immune function.

Diabetes: Genetic studies in patients with type 2 diabetes mellitus; role of the kidney in glucose metabolism.

Dupuytren's Disease: Medical therapy.

Genetics: Hematologic diseases and stroke.

HIV Disease: Pathogenesis of the metabolic complications.

Metabolism: Regulation of muscle wasting in catabolic illness; regulation of muscle metabolism by insulin and amino acids in normal adults; effects of dietary arginine supplements on metabolism in cancer patients; gut priming in neonatal adaptation to enteral nutrition in micropreemies.

Neurology: Neurologic complications and development of novel diagnostic testing for Lyme disease; cognitive dysfunction in multiple sclerosis.

Osteoporosis: Development of new therapeutic agents.

Psychiatry: Substance abuse and its effects on the brain dopamine system.

Renal Failure: Use of anabolic agents in children with chronic renal failure; role of nitric oxide in defense against infection in patients on peritoneal dialysis.

Contact Information

For information about this GCRC and how to access its resources, please contact:

Administrative Director
Nancy Wyllie
631-444-7737; Fax: 631-444-6930
E-mail: nwyllie@notes.cc.sunysb.edu

Program Director
Marie C. Gelato, M.D., Ph.D.
631-444-1175; Fax: 631-444-8951
E-mail: mgelato@notes.cc.sunysb.edu

Principal Investigator
Richard N. Fine, M.D.
631-444-1785; Fax: 631-444-1340
E-mail: rfine@notes.cc.sunysb.edu

Associate Program Director
Wadie Bahou, M.D.
631-444-2059; Fax: 631-444-7530
E-mail: wadie.bahou@sunysb.edu

Research Subject Advocate
Maureen Hurst, L.P.N., C.C.R.C.
631-444-7759
E-mail: mhurst@notes.cc.sunysb.edu

GCRC Advisory Committee Chairperson
Margaret McNurlan, Ph.D.
631-444-8095
E-mail: mmcnurlan@notes.cc.sunysb.edu

Nurse Manager
Tracy Dourdounas, B.A.,R.N., C.C.R.C.
631-444-7762; Fax: 631-444-6930
E-mail: tdourdounas@notes.cc.sunysb.edu

Core Laboratory Director
Margaret McNurlan, Ph.D.
631-444-8095; Fax: 631-444-8947
E-mail: mmcnurlan@notes.cc.sunysb.edu

Biostatistician
Hongshik Ahn, Ph.D.
631-444-7612; Fax: 631-444-8409
E-mail: hahn@notes.cc.sunysb.edu

Data Manager/Epidemiologist
Pat Pugliani, M.P.H.
631-444-6900; Fax: 631-444-6930
E-mail: Patricia.Pugliani@stonybrook.edu

Informatics Manager/Core Codirector
David Cyrille
631-444-7399; Fax: 631-444-6930
E-mail: dcyrille@notes.cc.sunysb.edu

Outreach Program Director
Hector Sepulveda, M.A., M.P.H., M.D.
631-444-3244; Fax: 631-444-6930
E-mail: hsepulveda@notes.cc.sunysb.edu