Our Science – Kobayashi Website

Hisataka Kobayashi, M.D., Ph.D.

Selected Publications

1) Levenson RM, Lynch DT, Kobayashi H, Backer JM, Backer MV.
Multiplexing with multispectral imaging: from mice to microscopy.
ILAR journal / National Research Council, Institute of Laboratory Animal Resources. 49: 78-88, 2008. [Journal]

2) Koyama Y, Talanov VS, Bernardo M, Hama Y, Regino CA, Brechbiel MW, Choyke PL, Kobayashi H.
A dendrimer-based nanosized contrast agent dual-labeled for magnetic resonance and optical fluorescence imaging to localize the sentinel lymph node in mice.
Journal of magnetic resonance imaging : JMRI. 25: 866-71, 2007. [Journal]

3) Hama Y, Urano Y, Koyama Y, Gunn AJ, Choyke PL, Kobayashi H.
A self-quenched galactosamine-serum albumin-rhodamineX conjugate: a.
Clin. Cancer Res. 13: 6335-43, 2007. [Journal]

4) Hama Y, Urano Y, Koyama Y, Kamiya M, Bernardo M, Paik RS, Shin IS, Paik CH, Choyke PL, Kobayashi H.
A target cell-specific activatable fluorescence probe for in vivo molecular imaging of cancer based on a self-quenched avidin-rhodamine conjugate.
Cancer Res. 67: 2791-9, 2007. [Journal]

5) Hama Y, Urano Y, Koyama Y, Choyke PL, Kobayashi H.
Activatable fluorescent molecular imaging of peritoneal metastases following pretargeting with a biotinylated monoclonal antibody.
Cancer Res. 67: 3809-17, 2007. [Journal]

6) Kamiya M, Kobayashi H, Hama Y, Koyama Y, Bernardo M, Nagano T, Choyke PL, Urano Y.
An enzymatically activated fluorescence probe for targeted tumor imaging.
J. Am. Chem. Soc. 129: 3918-29, 2007. [Journal]

7) Barrett T, Koyama Y, Hama Y, Ravizzini G, Shin IS, Jang BS, Paik CH, Urano Y, Choyke PL, Kobayashi H.
In vivo diagnosis of epidermal growth factor receptor expression using molecular imaging with a cocktail of optically labeled monoclonal antibodies.
Clin. Cancer Res. 13: 6639-48, 2007. [Journal]

8) Koyama Y, Barrett T, Hama Y, Ravizzini G, Choyke PL, Kobayashi H.
In vivo molecular imaging to diagnose and subtype tumors through receptor-targeted optically labeled monoclonal antibodies.
Neoplasia. 9: 1021-9, 2007. [Journal]

9) Hama Y, Bernardo M, Regino CA, Koyama Y, Brechbiel MW, Krishna MC, Choyke PL, Kobayashi H.
MR lymphangiography using dendrimer-based contrast agents: a comparison at 1.5T and 3.0T.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. 57: 431-6, 2007. [Journal]

10) Kobayashi H, Hama Y, Koyama Y, Barrett T, Regino CA, Urano Y, Choyke PL.
Simultaneous multicolor imaging of five different lymphatic basins using quantum dots.
Nano Lett. 7: 1711-6, 2007. [Journal]

11) Hama Y, Koyama Y, Urano Y, Choyke PL, Kobayashi H.
Simultaneous two-color spectral fluorescence lymphangiography with near infrared quantum dots to map two lymphatic flows from the breast and the upper extremity.
Breast Cancer Res. Treat. 103: 23-8, 2007. [Journal]

12) Kakinuma T, Nadiminti H, Lonsdorf AS, Murakami T, Perez BA, Kobayashi H, Finkelstein SE, Pothiawala G, Belkaid Y, Hwang ST.
Small numbers of residual tumor cells at the site of primary inoculation are critical for anti-tumor immunity following challenge at a secondary location.
Cancer Immunol. Immunother. 56: 1119-31, 2007. [Journal]

13) Koyama Y, Hama Y, Urano Y, Nguyen DM, Choyke PL, Kobayashi H.
Spectral fluorescence molecular imaging of lung metastases targeting HER2/neu.
Clin. Cancer Res. 13: 2936-45, 2007. [Journal]

14) Hama Y, Koyama Y, Bernardo M, Choyke PL, Kobayashi H.
Spectral near-infrared fluorescence imaging of curved surfaces using projection reconstruction algorithms.
Contrast media & molecular imaging. 2: 82-7, 2007. [Journal]

15) Gunn AJ, Hama Y, Koyama Y, Kohn EC, Choyke PL, Kobayashi H.
Targeted optical fluorescence imaging of human ovarian adenocarcinoma using a galactosyl serum albumin-conjugated fluorophore.
Cancer Sci. 98: 1727-33, 2007. [Journal]

16) Xu H, Regino CA, Bernardo M, Koyama Y, Kobayashi H, Choyke PL, Brechbiel MW.
Toward improved syntheses of dendrimer-based magnetic resonance imaging contrast agents: new bifunctional diethylenetriaminepentaacetic acid ligands and nonaqueous conjugation chemistry.
J. Med. Chem. 50: 3185-93, 2007. [Journal]

17) Hama Y, Koyama Y, Urano Y, Choyke PL, Kobayashi H.
Two-color lymphatic mapping using Ig-conjugated near infrared optical probes.
J. Invest. Dermatol. 127: 2351-6, 2007. [Journal]

18) Kobayashi H, Kawamoto S, Bernardo M, Brechbiel MW, Knopp MV, Choyke PL.
Delivery of gadolinium-labeled nanoparticles to the sentinel lymph node: comparison of the sentinel node visualization and estimations of intra-nodal gadolinium concentration by the magnetic resonance imaging.
Journal of controlled release : official journal of the Controlled Release Society. 111: 343-51, 2006. [Journal]

19) Talanov VS, Regino CA, Kobayashi H, Bernardo M, Choyke PL, Brechbiel MW.
Dendrimer-based nanoprobe for dual modality magnetic resonance and fluorescence imaging.
Nano Lett. 6: 1459-63, 2006. [Journal]

20) Dear JW, Kobayashi H, Brechbiel MW, Star RA.
Imaging acute renal failure with polyamine dendrimer-based MRI contrast agents.
Nephron. Clinical practice. 103: c45-9, 2006. [Journal]

21) Barrett T, Choyke PL, Kobayashi H.
Imaging of the lymphatic system: new horizons.
Contrast media & molecular imaging. 1: 230-45, 2006. [Journal]

22) Hama Y, Urano Y, Koyama Y, Kamiya M, Bernardo M, Paik RS, Krishna MC, Choyke PL, Kobayashi H.
In vivo spectral fluorescence imaging of submillimeter peritoneal cancer implants using a lectin-targeted optical agent.
Neoplasia. 8: 607-12, 2006. [Journal]

23) Barrett T, Kobayashi H, Brechbiel M, Choyke PL.
Macromolecular MRI contrast agents for imaging tumor angiogenesis.
European journal of radiology. 60: 353-66, 2006. [Journal]

24) Hama Y, Urano Y, Koyama Y, Choyke PL, Kobayashi H.
Targeted optical imaging of cancer cells using lectin-binding BODIPY conjugated avidin.
Biochem. Biophys. Res. Commun. 348: 807-13, 2006. [Journal]

25) Dear JW, Kobayashi H, Jo SK, Holly MK, Hu X, Yuen PS, Brechbiel MW, Star RA.
Dendrimer-enhanced MRI as a diagnostic and prognostic biomarker of sepsis-induced acute renal failure in aged mice.
Kidney Int. 67: 2159-67, 2005. [Journal]

26) Kobayashi H, Kawamoto S, Brechbiel MW, Bernardo M, Sato N, Waldmann TA, Tagaya Y, Choyke PL.
Detection of lymph node involvement in hematologic malignancies using micromagnetic resonance lymphangiography with a gadolinum-labeled dendrimer nanoparticle.
Neoplasia. 7: 984-91, 2005. [Journal]

27) Sugaya M, Watanabe T, Yang A, Starost MF, Kobayashi H, Atkins AM, Borris DL, Hanan EA, Schimel D, Bryant MA, Roberts N, Skobe M, Staskus KA, Kaldis P, Blauvelt A.
Lymphatic dysfunction in transgenic mice expressing KSHV k-cyclin under the control of the VEGFR-3 promoter.
Blood. 105: 2356-63, 2005. [Journal]

28) Kobayashi H, Brechbiel MW.
Nano-sized MRI contrast agents with dendrimer cores.
Adv. Drug Deliv. Rev. 57: 2271-86, 2005. [Journal]

29) Kataoka ML, Togashi K, Yamaoka T, Koyama T, Ueda H, Kobayashi H, Rahman M, Higuchi T, Fujii S.
Posterior cul-de-sac obliteration associated with endometriosis: MR imaging evaluation.
Radiology. 234: 815-23, 2005. [Journal]

30) Kobayashi H, Dubois S, Sato N, Sabzevari H, Sakai Y, Waldmann TA, Tagaya Y.
Role of trans-cellular IL-15 presentation in the activation of NK cell-mediated killing, which leads to enhanced tumor immunosurveillance.
Blood. 105: 721-7, 2005. [Journal]

31) Kobayashi H, Reijnders K, English S, Yordanov AT, Milenic DE, Sowers AL, Citrin D, Krishna MC, Waldmann TA, Mitchell JB, Brechbiel MW.
Application of a macromolecular contrast agent for detection of alterations of tumor vessel permeability induced by radiation.
Clin. Cancer Res. 10: 7712-20, 2004. [Journal]

32) Kobayashi H, Brechbiel MW.
Dendrimer-based nanosized MRI contrast agents.
Current pharmaceutical biotechnology. 5: 539-49, 2004. [Journal]

33) Mamede M, Saga T, Ishimori T, Higashi T, Sato N, Kobayashi H, Brechbiel MW, Konishi J.
Hepatocyte targeting of 111In-labeled oligo-DNA with avidin or avidin-dendrimer complex.
Journal of controlled release : official journal of the Controlled Release Society. 95: 133-41, 2004. [Journal]

34) Mandler R, Kobayashi H, Hinson ER, Brechbiel MW, Waldmann TA.
Herceptin-geldanamycin immunoconjugates: pharmacokinetics, biodistribution, and enhanced antitumor activity.
Cancer Res. 64: 1460-7, 2004. [Journal]

35) Kobayashi H, Kawamoto S, Sakai Y, Choyke PL, Star RA, Brechbiel MW, Sato N, Tagaya Y, Morris JC, Waldmann TA.
Lymphatic drainage imaging of breast cancer in mice by micro-magnetic resonance lymphangiography using a nano-size paramagnetic contrast agent.
J. Natl. Cancer Inst. 96: 703-8, 2004. [Journal]

36) Kobayashi H, Kawamoto S, Brechbiel MW, Jo SK, Hu X, Yang T, Diwan BA, Waldmann TA, Schnermann J, Choyke PL, Star RA.
Micro-MRI methods to detect renal cysts in mice.
Kidney Int. 65: 1511-6, 2004. [Journal]

37) Kobayashi H, Jo SK, Kawamoto S, Yasuda H, Hu X, Knopp MV, Brechbiel MW, Choyke PL, Star RA.
Polyamine dendrimer-based MRI contrast agents for functional kidney imaging to diagnose acute renal failure.
Journal of magnetic resonance imaging : JMRI. 20: 512-8, 2004. [Journal]

38) Kobayashi H, Kawamoto S, Choyke PL, Sato N, Knopp MV, Star RA, Waldmann TA, Tagaya Y, Brechbiel MW.
Comparison of dendrimer-based macromolecular contrast agents for dynamic micro-magnetic resonance lymphangiography.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. 50: 758-66, 2003. [Journal]

39) Kobayashi H, Brechbiel MW.
Dendrimer-based macromolecular MRI contrast agents: characteristics and application.
Molecular imaging : official journal of the Society for Molecular Imaging. 2: 1-10, 2003. [Journal]

40) Jo SK, Hu X, Kobayashi H, Lizak M, Miyaji T, Koretsky A, Star RA.
Detection of inflammation following renal ischemia by magnetic resonance imaging.
Kidney Int. 64: 43-51, 2003. [Journal]

41) Shirakawa K, Kobayashi H, Sobajima J, Hashimoto D, Shimizu A, Wakasugi H.
Inflammatory breast cancer: vasculogenic mimicry and its hemodynamics of an inflammatory breast cancer xenograft model.
Breast Cancer Res. 5: 136-9, 2003. [Journal]

42) Kobayashi H, Kawamoto S, Star RA, Waldmann TA, Tagaya Y, Brechbiel MW.
Micro-magnetic resonance lymphangiography in mice using a novel dendrimer-based magnetic resonance imaging contrast agent.
Cancer Res. 63: 271-6, 2003. [Journal]

43) Nakamoto Y, Saga T, Higashi T, Ishimori T, Kobayashi H, Ishizu K, Sato N, Mamede M, Sakahara H, Imamura M, Konishi J.
Optimal scan time for evaluating pancreatic disease with positron emission tomography using F-18-fluorodeoxyglucose.
Annals of nuclear medicine. 17: 421-6, 2003. [Journal]

44) Mamede M, Saga T, Kobayashi H, Ishimori T, Higashi T, Sato N, Brechbiel MW, Konishi J.
Radiolabeling of avidin with very high specific activity for internal radiation therapy of intraperitoneally disseminated tumors.
Clin. Cancer Res. 9: 3756-62, 2003. [Journal]

45) Nakai A, Togashi K, Yamaoka T, Fujiwara T, Ueda H, Koyama T, Kobayashi H, Kagimura T, Fujii S, Konishi J.
Uterine peristalsis shown on cine MR imaging using ultrafast sequence.
Journal of magnetic resonance imaging : JMRI. 18: 726-33, 2003. [Journal]

46) Shirakawa K, Kobayashi H, Heike Y, Kawamoto S, Brechbiel MW, Kasumi F, Iwanaga T, Konishi F, Terada M, Wakasugi H.
Hemodynamics in vasculogenic mimicry and angiogenesis of inflammatory breast cancer xenograft.
Cancer Res. 62: 560-6, 2002. [Journal]

47) Kim MK, Jeong HJ, Kao CH, Yao Z, Paik DS, Pie JE, Kobayashi H, Waldmann TA, Carrasquillo JA, Paik CH.
Improved renal clearance and tumor targeting of 99mTc-labeled anti-Tac monoclonal antibody Fab by chemical modifications.
Nucl. Med. Biol. 29: 139-46, 2002. [Journal]

48) Ishimori T, Saga T, Mamede M, Kobayashi H, Higashi T, Nakamoto Y, Sato N, Konishi J.
Increased (18)F-FDG uptake in a model of inflammation: concanavalin A-mediated lymphocyte activation.
J. Nucl. Med. 43: 658-63, 2002. [Journal]

49) Kim I, Kobayashi H, Yoo TM, Kim MK, Le N, Han ES, Wang QC, Pastan I, Carrasquillo JA, Paik CH.
Lowering of pI by acylation improves the renal uptake of 99mTc-labeled anti-Tac dsFv: effect of different acylating reagents.
Nucl. Med. Biol. 29: 795-801, 2002. [Journal]

50) Kobayashi H, Shirakawa K, Kawamoto S, Saga T, Sato N, Hiraga A, Watanabe I, Heike Y, Togashi K, Konishi J, Brechbiel MW, Wakasugi H.
Rapid accumulation and internalization of radiolabeled herceptin in an inflammatory breast cancer xenograft with vasculogenic mimicry predicted by the contrast-enhanced dynamic MRI with the macromolecular contrast agent G6-(1B4M-Gd)(256).
Cancer Res. 62: 860-6, 2002. [Journal]

51) Kobayashi H, Kawamoto S, Jo SK, Sato N, Saga T, Hiraga A, Konishi J, Hu S, Togashi K, Brechbiel MW, Star RA.
Renal tubular damage detected by dynamic micro-MRI with a dendrimer-based magnetic resonance contrast agent.
Kidney Int. 61: 1980-5, 2002. [Journal]

52) Nakai T, Muraki S, Kato C, Sugio T, Matsuo K, Miki Y, Kobayashi H, Ueda H, Ogata M, Liu X, Konishi J, Togashi K.
[Development of three-dimensional stereo viewer for high-resolution data].
Nihon Igaku Hoshasen Gakkai zasshi. Nippon acta radiologica. 61: 103-5, 2001. [Journal]

53) Kobayashi H, Sato N, Kawamoto S, Saga T, Hiraga A, Ishimori T, Konishi J, Togashi K, Brechbiel MW.
3D MR angiography of intratumoral vasculature using a novel macromolecular MR contrast agent.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. 46: 579-85, 2001. [Journal]

54) Kobayashi H, Sato N, Hiraga A, Saga T, Nakamoto Y, Ueda H, Konishi J, Togashi K, Brechbiel MW.
3D-micro-MR angiography of mice using macromolecular MR contrast agents with polyamidoamine dendrimer core with reference to their pharmacokinetic properties.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. 45: 454-60, 2001. [Journal]

55) Kobayashi H, Saga T, Kawamoto S, Sato N, Hiraga A, Ishimori T, Konishi J, Togashi K, Brechbiel MW.
Dynamic micro-magnetic resonance imaging of liver micrometastasis in mice with a novel liver macromolecular magnetic resonance contrast agent DAB-Am64-(1B4M-Gd)(64).
Cancer Res. 61: 4966-70, 2001. [Journal]

56) Saga T, Sakahara H, Nakamoto Y, Sato N, Ishimori T, Mamede M, Kobayashi H, Masunaga S, Sasai K, Kuroki M, Konishi J.
Enhancement of the therapeutic outcome of radio-immunotherapy by combination with whole-body mild hyperthermia.
Eur. J. Cancer. 37: 1429-34, 2001. [Journal]

57) Kobayashi H, Kawamoto S, Saga T, Sato N, Hiraga A, Konishi J, Togashi K, Brechbiel MW.
Micro-MR angiography of normal and intratumoral vessels in mice using dedicated intravascular MR contrast agents with high generation of polyamidoamine dendrimer core: reference to pharmacokinetic properties of dendrimer-based MR contrast agents.
Journal of magnetic resonance imaging : JMRI. 14: 705-13, 2001. [Journal]

58) Kobayashi H, Sato N, Kawamoto S, Saga T, Hiraga A, Ishimori T, Konishi J, Togashi K, Brechbiel MW.
Novel intravascular macromolecular MRI contrast agent with generation-4 polyamidoamine dendrimer core: accelerated renal excretion with coinjection of lysine.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. 46: 457-64, 2001. [Journal]

59) Kobayashi H, Kawamoto S, Saga T, Sato N, Hiraga A, Ishimori T, Akita Y, Mamede MH, Konishi J, Togashi K, Brechbiel MW.
Novel liver macromolecular MR contrast agent with a polypropylenimine diaminobutyl dendrimer core: comparison to the vascular MR contrast agent with the polyamidoamine dendrimer core.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. 46: 795-802, 2001. [Journal]

60) Sato N, Kobayashi H, Hiraga A, Saga T, Togashi K, Konishi J, Brechbiel MW.
Pharmacokinetics and enhancement patterns of macromolecular MR contrast agents with various sizes of polyamidoamine dendrimer cores.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. 46: 1169-73, 2001. [Journal]

61) Kobayashi H, Kawamoto S, Tamaki T, Konishi J, Togashi K.
Polysplenia associated with semiannular pancreas.
European radiology. 11: 1639-41, 2001. [Journal]

62) Kobayashi H, Kawamoto S, Saga T, Sato N, Hiraga A, Ishimori T, Konishi J, Togashi K, Brechbiel MW.
Positive effects of polyethylene glycol conjugation to generation-4 polyamidoamine dendrimers as macromolecular MR contrast agents.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. 46: 781-8, 2001. [Journal]

63) Sato N, Kobayashi H, Saga T, Nakamoto Y, Ishimori T, Togashi K, Fujibayashi Y, Konishi J, Brechbiel MW.
Tumor targeting and imaging of intraperitoneal tumors by use of antisense oligo-DNA complexed with dendrimers and/or avidin in mice.
Clin. Cancer Res. 7: 3606-12, 2001. [Journal]

64) Haque TL, Togashi K, Kobayashi H, Fujii S, Konishi J.
Adnexal torsion: MR imaging findings of viable ovary.
European radiology. 10: 1954-7, 2000. [Journal]

65) Kobayashi H, Togashi K.
CT of tattoos removed with laser therapy.
AJR. American journal of roentgenology. 174: 1468-9, 2000. [Journal]

66) Kobayashi H, Carrasquillo JA, Paik CH, Waldmann TA, Tagaya Y.
Differences of biodistribution, pharmacokinetics, and tumor targeting between interleukins 2 and 15.
Cancer Res. 60: 3577-83, 2000. [Journal]

67) Sun BF, Kobayashi H, Le N, Yoo TM, Drumm D, Paik CH, McAfee JG, Carrasquillo JA.
Effects of insulinlike growth factor binding proteins on insulinlike growth factor-I biodistribution in tumor-bearing nude mice.
J. Nucl. Med. 41: 318-26, 2000. [Journal]

68) Nakamoto Y, Saga T, Misaki T, Kobayashi H, Sato N, Ishimori T, Kosugi S, Sakahara H, Konishi J.
Establishment and characterization of a breast cancer cell line expressing Na+/I- symporters for radioiodide concentrator gene therapy.
J. Nucl. Med. 41: 1898-904, 2000. [Journal]

69) Kobayashi H, Sato N, Saga T, Nakamoto Y, Ishimori T, Toyama S, Togashi K, Konishi J, Brechbiel MW.
Monoclonal antibody-dendrimer conjugates enable radiolabeling of antibody with markedly high specific activity with minimal loss of immunoreactivity.
European journal of nuclear medicine. 27: 1334-9, 2000. [Journal]

70) Kobayashi H, Kao CH, Kreitman RJ, Le N, Kim MK, Brechbiel MW, Paik CH, Pastan I, Carrasquillo JA.
Pharmacokinetics of 111In- and 125I-labeled antiTac single-chain Fv recombinant immunotoxin.
J. Nucl. Med. 41: 755-62, 2000. [Journal]

71) Kim M, Seidel J, Le N, Kim IS, Yoo TM, Barker C, Kobayashi H, Green MV, Carrasquillo JA, Paik CH.
Evaluation of 99mTc-mercaptoacetyltriglycine-biocytin as a new hepatobiliary imaging agent in mice coinjected with bilirubin.
Nucl. Med. Biol. 26: 43-9, 1999. [Journal]

72) Kataoka ML, Togashi K, Kobayashi H, Inoue T, Fujii S, Konishi J.
Evaluation of ectopic pregnancy by magnetic resonance imaging.
Hum. Reprod. 14: 2644-50, 1999. [Journal]

73) Kobayashi H, Kim IS, Drumm D, Kim MK, Paik DS, Le N, Waldmann TA, Carrasquillo JA, Paik CH.
Favorable effects of glycolate conjugation on the biodistribution of humanized antiTac Fab fragment.
J. Nucl. Med. 40: 837-45, 1999. [Journal]

74) Kobayashi H, Sun BF, Yoo TM, Le N, Kim MK, Paik CH, Pastan I, Waldmann TA, Carrasquillo JA.
Methods to avoid adverse effect of circulating antigen on biodistribution of 125I-labeled antiTac dsFv: preinjection of intact antibody versus clearance of antigen with adivin-biotin system.
J. Nucl. Med. 40: 1381-91, 1999. [Journal]

75) Koyama T, Togashi K, Konishi I, Kobayashi H, Ueda H, Kataoka ML, Kobayashi H, Itoh T, Higuchi T, Fujii S, Konishi J.
MR imaging of endometrial stromal sarcoma: correlation with pathologic findings.
AJR. American journal of roentgenology. 173: 767-72, 1999. [Journal]

76) Kobayashi H, Le N, Kim IS, Kim MK, Pie JE, Drumm D, Paik DS, Waldmann TA, Paik CH, Carrasquillo JA.
The pharmacokinetic characteristics of glycolated humanized anti-Tac Fabs are determined by their isoelectric points.
Cancer Res. 59: 422-30, 1999. [Journal]

77) Ueda H, Togashi K, Konishi I, Kataoka ML, Koyama T, Fujiwara T, Kobayashi H, Fujii S, Konishi J.
Unusual appearances of uterine leiomyomas: MR imaging findings and their histopathologic backgrounds.
Radiographics : a review publication of the Radiological Society of North America, Inc. 19 Spec No: S131-45, 1999. [Journal]

78) Kobayashi H, Tagaya Y, Han ES, Kim IS, Le N, Paik CH, Pastan I, Nelson DL, Waldmann TA, Carrasquillo JA.
Use of an antibody against the soluble interleukin 2 receptor alpha subunit can modulate the stability and biodistribution of interleukin-2.
Cytokine. 11: 1065-75, 1999. [Journal]

79) Kobayashi H, Sun BF, Han ES, Kim MK, Le N, Wang QC, Nelson DL, Pastan I, Waldmann TA, Paik CH, Carrasquillo JA.
Epitope blocking: positive and negative effects on the biodistribution of 125I-labeled anti-Tac disulfide-stabilized Fv fragment of two antibodies against different epitopes of the circulating antigen.
Jpn. J. Cancer Res. 89: 436-44, 1998. [Journal]

80) Kobayashi H, Wu C, Yoo TM, Sun BF, Drumm D, Pastan I, Paik CH, Gansow OA, Carrasquillo JA, Brechbiel MW.
Evaluation of the in vivo biodistribution of yttrium-labeled isomers of CHX-DTPA-conjugated monoclonal antibodies.
J. Nucl. Med. 39: 829-36, 1998. [Journal]

81) Yao Z, Zhang M, Sakahara H, Saga T, Kobayashi H, Nakamoto Y, Toyama S, Konishi J.
Increased streptavidin uptake in tumors pretargeted with biotinylated antibody using a conjugate of streptavidin-fab fragment.
Nucl. Med. Biol. 25: 557-60, 1998. [Journal]

82) Kobayashi H, Han ES, Kim IS, Le N, Rajagopal V, Kreitman RJ, Pastan I, Paik CH, Carrasquillo JA.
Similarities in the biodistribution of iodine-labeled anti-Tac single-chain disulfide-stabilized Fv fragment and anti-Tac disulfide-stabilized Fv fragment.
Nucl. Med. Biol. 25: 387-93, 1998. [Journal]

83) Kim MK, Song BJ, Seidel J, Soh Y, Jeong KS, Kim IS, Kobayashi H, Green MV, Carrasquillo JA, Paik CH.
Use of 99mTc-mercaptoacetyltriglycine (MAG3)-biocytin hepatobiliary scintigraphy to study the protective effect of a synthetic enzyme inhibitor on acute hepatotoxicity in mice.
Nucl. Med. Biol. 25: 561-8, 1998. [Journal]

84) Sun BF, Kobayashi H, Le N, Yoo TM, Drumm D, Paik CH, McAfee JG, Carrasquillo JA.
Biodistribution of 125I-labeled des(1-3) insulin-like growth factor I in tumor-bearing nude mice and its in vitro catabolism.
Cancer Res. 57: 2754-9, 1997. [Journal]

85) Kobayashi H, Yoo TM, Drumm D, Kim MK, Sun BF, Le N, Webber KO, Pastan I, Waldmann TA, Paik CH, Carrasquillo JA.
Improved biodistribution of 125I-labeled anti-Tac disulfide-stabilized Fv fragment by blocking its binding to the alpha subunit of the interleukin 2 receptor in the circulation with preinjected humanized anti-Tac IgG.
Cancer Res. 57: 1955-61, 1997. [Journal]

86) Hosono M, Kobayashi H, Fujimoto R, Tsutsui K, Kotoura Y, Tsuboyama T, Hayashi H, Nakamura T, Konishi J.
MR appearance of parasymphseal insufficiency fractures of the os pubis.
Skeletal Radiol. 26: 525-8, 1997. [Journal]

87) Hosono M, Kobayashi H, Fujimoto R, Kotoura Y, Tsuboyama T, Matsusue Y, Nakamura T, Itoh T, Konishi J.
Septum-like structures in lipoma and liposarcoma: MR imaging and pathologic correlation.
Skeletal Radiol. 26: 150-4, 1997. [Journal]

88) Wu C, Kobayashi H, Sun B, Yoo TM, Paik CH, Gansow OA, Carrasquillo JA, Pastan I, Brechbiel MW.
Stereochemical influence on the stability of radio-metal complexes in vivo. Synthesis and evaluation of the four stereoisomers of 2-(p-nitrobenzyl)-trans-CyDTPA.
Bioorg. Med. Chem. 5: 1925-34, 1997. [Journal]

89) Nakamoto Y, Sakahara H, Kobayashi H, Saga T, Tsuboyama N, Nakamura T, Konishi J.
Technetium-99m (V)-dimercaptosuccinic acid: normal accumulation in the breasts.
European journal of nuclear medicine. 24: 1146-8, 1997. [Journal]

90) Kobayashi H, Shigeno C, Sakahara H, Yamamoto T, Hosono M, Fujimoto R, Konishi J.
Three phase 99Tcm (V)DMSA scintigraphy in Paget's disease: an indicator of pamidronate effect.
The British journal of radiology. 70: 1056-9, 1997. [Journal]

91) Sakahara H, Hosono M, Kobayashi H, Yao Z, Saga T, Yano S, Endo K, Mori T, Konishi J.
Effect of circulating antigen on immunoscintigraphy of ovarian cancer patients using anti-CA125 monoclonal antibody.
Jpn. J. Cancer Res. 87: 655-61, 1996. [Journal]

92) Kobayashi H, Sakahara H, Endo K, Yao ZS, Konishi J.
Inflammation-seeking scintigraphy with radiolabeled biotinylated polyclonal IgG followed by the injection of avidin chase.
Nucl. Med. Biol. 23: 29-32, 1996. [Journal]

93) Kobayashi H, Yoo TM, Kim IS, Kim MK, Le N, Webber KO, Pastan I, Paik CH, Eckelman WC, Carrasquillo JA.
L-lysine effectively blocks renal uptake of 125I- or 99mTc-labeled anti-Tac disulfide-stabilized Fv fragment.
Cancer Res. 56: 3788-95, 1996. [Journal]

94) Kobayashi H, Kotoura Y, Hosono M, Tsuboyama T, Sakahara H, Konishi J.
Periosteal ganglion of the tibia.
Skeletal Radiol. 25: 381-3, 1996. [Journal]

95) Kobayashi H, Sakahara H, Endo K, Hosono M, Yao ZS, Toyama S, Konishi J.
Comparison of the chase effects of avidin, streptavidin, neutravidin, and avidin-ferritin on a radiolabeled biotinylated anti-tumor monoclonal antibody.
Jpn. J. Cancer Res. 86: 310-4, 1995. [Journal]

96) Kobayashi H, Kotoura Y, Hosono M, Sakahara H, Hosono M, Yao ZS, Tsuboyama T, Yamamuro T, Endo K, Konishi J.
Diagnostic value of Tc-99m (V) DMSA for chondrogenic tumors with positive Tc-99m HMDP uptake on bone scintigraphy.
Clinical nuclear medicine. 20: 361-4, 1995. [Journal]

97) Yao Z, Zhang M, Kobayashi H, Sakahara H, Nakada H, Yamashina I, Konishi J.
Improved targeting of radiolabeled streptavidin in tumors pretargeted with biotinylated monoclonal antibodies through an avidin chase.
J. Nucl. Med. 36: 837-41, 1995. [Journal]

98) Kobayashi H, Kotoura Y, Tsuboyama T, Hosono M, Sakahara H, Konishi J.
Incidental detection of papillary carcinoma of the thyroid by Tc-99m (V) DMSA tumor scintigraphy.
Clinical nuclear medicine. 20: 638, 1995. [Journal]

99) Hosono M, Sone N, Endo K, Saga T, Kobayashi H, Hosono MN, Sakahara H, Yasunaga K, Konishi J.
Kinetics of platelets in dogs with thrombocytopenia induced by antiglycoprotein IIb/IIIa receptor monoclonal antibody.
Nucl. Med. Biol. 22: 71-6, 1995. [Journal]

100) Kobayashi H, Suzuki KH, Sakahara H, Yao ZS, Yokoyama A, Konishi J.
Oxygen bubbling can improve the labelling of pentavalent technetium-99m dimercaptosuccinic acid.
European journal of nuclear medicine. 22: 559-62, 1995. [Journal]

101) Hosono M, Takaori-Kondo A, Yao ZS, Kobayashi H, Hosono MN, Sakahara H, Imada K, Okuma M, Uchiyama T, Konishi J.
Radioimmunodetection of human leukemia with anti-interleukin-2 receptor antibody in severe combined immunodeficiency mice.
Nucl. Med. Biol. 22: 869-74, 1995. [Journal]

102) Yao Z, Sakahara H, Zhang M, Kobayashi H, Nakada H, Yamashina I, Konishi J.
Radioimmunoimaging of colon cancer xenografts with anti-Tn monoclonal antibody.
Nucl. Med. Biol. 22: 199-203, 1995. [Journal]

103) Kobayashi H, Sakahara H, Endo K, Yao ZS, Toyama S, Konishi J.
Repeating the avidin.
Eur. J. Cancer. 31A: 1689-96, 1995. [Journal]

104) Kobayashi H, Hosono M, Fujimoto R, Konishi J.
Tumoral calcinosis-like metastatic calcification in a patient with renal osteodystrophy: CT and scintigraphic appearances.
Clinical nuclear medicine. 20: 1112-4, 1995. [Journal]

105) Kobayashi H, Kotoura Y, Hosono M, Sakahara H, Yamamuro T, Endo K, Konishi J.
Case report: uptake of pentavalent technetium-99m dimercaptosuccinic acid by pigmented villonodular synovitis: comparison with computed tomography, magnetic resonance imaging and gallium-67 scintigraphy.
The British journal of radiology. 67: 1030-2, 1994. [Journal]

106) Kobayashi H, Sakahara H, Hosono M, Yao ZS, Toyama S, Endo K, Konishi J.
Improved clearance of radiolabeled biotinylated monoclonal antibody following the infusion of avidin as a.
J. Nucl. Med. 35: 1677-84, 1994. [Journal]

107) Kobayashi H, Shigeno C, Sakahara H, Hosono M, Hosono M, Yao ZS, Endo K, Konishi J.
Intraosseous hemangiomatosis: technetium-99m(V)dimercaptosuccinic acid and technetium-99m-hydroxymethylene diphosphonate imaging.
J. Nucl. Med. 35: 1482-4, 1994. [Journal]

108) Sakahara H, Onodera H, Kobayashi H, Yao Z, Yamashina I, Konishi J.
Reduced bone marrow uptake of indium-111 labelled monoclonal antibody after radiotherapy.
European journal of nuclear medicine. 21: 1252-3, 1994. [Journal]

109) Kobayashi H, Kotoura Y, Sakahara H, Hosono M, Hosono M, Tsaboyama T, Yamamuro T, Endo K, Konishi J.
Schwannoma of the extremities: comparison of MRI and pentavalent technetium-99m-dimercaptosuccinic acid and gallium-67-citrate scintigraphy.
J. Nucl. Med. 35: 1174-8, 1994. [Journal]

110) Kobayashi H, Sakahara H, Hosono M, Shirato M, Kondo S, Miyatake S, Kikuchi H, Namba Y, Endo K, Konishi J.
Scintigraphic detection of neural-cell-derived small-cell lung cancer using glioma-specific antibody.
J. Cancer Res. Clin. Oncol. 120: 259-62, 1994. [Journal]

111) Kobayashi H, Sakahara H, Hosono M, Shirato M, Endo K, Kotoura Y, Yamamuro T, Konishi J.
Soft-tissue tumors: diagnosis with Tc-99m (V) dimercaptosuccinic acid scintigraphy.
Radiology. 190: 277-80, 1994. [Journal]

112) Kobayashi H, Kotoura Y, Sakahara H, Yamamuro T, Endo K, Konishi J.
Solitary muscular sarcoidosis: CT, MRI, and scintigraphic characteristics.
Skeletal Radiol. 23: 293-5, 1994. [Journal]

113) Kobayashi H, Sakahara H, Hosono M, Shirato M, Konishi J, Takahashi JA, Oda Y, Kikuchi H, Endo K, Kozai Y.
Scintigraphic detection of xenografted tumors producing human basic fibroblast growth factor.
Cancer Immunol. Immunother. 37: 281-5, 1993. [Journal]

114) Kobayashi H, Sakahara H, Hosono M, Shirato M, Konishi J, Kotoura Y, Yamamuro T, Endo K.
Scintigraphic evaluation of tenosynovial giant-cell tumor using technetium-99m(V)-dimercaptosuccinic acid.
J. Nucl. Med. 34: 1745-7, 1993. [Journal]

115) Kobayashi H, Sakahara H, Itoh T, Kudoh T, Takagi T, Shibuya K, Nomura S, Hosono M, Endo K, Konishi J.
Technetium-99m(V)dimercaptosuccinic acid uptake in intra-abdominal massive deposit of amyloid protein.
J. Nucl. Med. 34: 815-7, 1993. [Journal]

116) Kobayashi H, Itoh T, Murata R, Tanabe M.
Primary retroperitoneal plasmacytoma with tumor thrombus within the renal vein.
J. Urol. 147: 452-4, 1992. [Journal]

117) Kobayashi H, Itoh T, Murata R, Tanabe M.
Pancreatic cavernous hemangioma: CT, MRI, US, and angiography characteristics.
Gastrointestinal radiology. 16: 307-10, 1991. [Journal]

118) Kobayashi H, Kotoura Y, Hosono M, Fujimoto R, Tsuboyama T, Itoh H, Konishi J.
3D-spiral CT of multiple exostoses.
Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society. 19: 419-22, , ,. [Journal]

119) Hama Y, Urano Y, Koyama Y, Bernardo M, Choyke PL, Kobayashi H.
A comparison of the emission efficiency of four common green fluorescence dyes after internalization into cancer cells.
Bioconjug. Chem. 17: 1426-31, , ,. [Journal]

120) Kobayashi H, Kawamoto S, Star RA, Waldmann TA, Brechbiel MW, Choyke PL.
Activated clearance of a biotinylated macromolecular MRI contrast agent from the blood pool using an avidin chase.
Bioconjug. Chem. 14: 1044-7, , ,. [Journal]

121) Kobayashi H, Kawamoto S, Saga T, Sato N, Ishimori T, Konishi J, Ono K, Togashi K, Brechbiel MW.
Avidin-dendrimer-(1B4M-Gd)(254): a tumor-targeting therapeutic agent for gadolinium neutron capture therapy of intraperitoneal disseminated tumor which can be monitored by MRI.
Bioconjug. Chem. 12: 587-93, , ,. [Journal]

122) Kim IS, Yoo TM, Kobayashi H, Kim MK, Le N, Wang QC, Pastan I, Carrasquillo JA, Paik CH.
Chemical modification to reduce renal uptake of disulfide-bonded variable region fragment of anti-Tac monoclonal antibody labeled with 99mTc.
Bioconjug. Chem. 10: 447-53, , ,. [Journal]

123) Kobayashi H, Sato N, Kawamoto S, Saga T, Hiraga A, Haque TL, Ishimori T, Konishi J, Togashi K, Brechbiel MW.
Comparison of the macromolecular MR contrast agents with ethylenediamine-core versus ammonia-core generation-6 polyamidoamine dendrimer.
Bioconjug. Chem. 12: 100-7, , ,. [Journal]

124) Hama Y, Urano Y, Koyama Y, Choyke PL, Kobayashi H.
D-galactose receptor-targeted in vivo spectral fluorescence imaging of peritoneal metastasis using galactosamin-conjugated serum albumin-rhodamine green.
Journal of biomedical optics. 12: 051501, , ,. [Journal]

125) Kobayashi H, Itoh T, Sasaki Y, Konishi J.
Diagnostic imaging of idiopathic adult respiratory distress syndrome (ARDS)/diffuse alveolar damage (DAD) histopathological correlation with radiological imaging.
Clinical imaging. 20: 1-7, , ,. [Journal]

126) Mamede M, Saga T, Ishimori T, Nakamoto Y, Sato N, Higashi T, Mukai T, Kobayashi H, Konishi J.
Differential uptake of (18)F-fluorodeoxyglucose by experimental tumors xenografted into immunocompetent and immunodeficient mice and the effect of immunomodification.
Neoplasia. 5: 179-83, , ,. [Journal]

127) Kobayashi H, Itoh T, Itoh H, Konishi J.
Duct ectasia due to mucus-producing cancers with intraductal extension: histopathologic correlation with radiologic imagings.
Abdominal imaging. 20: 341-7, , ,. [Journal]

128) Kobayashi H, Wu C, Kim MK, Paik CH, Carrasquillo JA, Brechbiel MW.
Evaluation of the in vivo biodistribution of indium-111 and yttrium-88 labeled dendrimer-1B4M-DTPA and its conjugation with anti-Tac monoclonal antibody.
Bioconjug. Chem. 10: 103-11, , ,. [Journal]

129) Choyke PL, Kobayashi H.
Functional magnetic resonance imaging of the kidney using macromolecular contrast agents.
Abdominal imaging. 31: 224-31, , ,. [Journal]

130) Hosono M, Kobayashi H, Kotoura Y, Tsuboyama T, Tsutsui K, Konishi J.
Involvement of muscle by malignant lymphoma: MR and CT appearances.
Journal of computer assisted tomography. 19: 455-9, , ,. [Journal]

131) Kobayashi H, Kawamoto S, Jo SK, Bryant HL, Brechbiel MW, Star RA.
Macromolecular MRI contrast agents with small dendrimers: pharmacokinetic differences between sizes and cores.
Bioconjug. Chem. 14: 388-94, , ,. [Journal]

132) Mandler R, Kobayashi H, Davis MY, Waldmann TA, Brechbiel MW.
Modifications in synthesis strategy improve the yield and efficacy of geldanamycin-herceptin immunoconjugates.
Bioconjug. Chem. 13: 786-91, , ,. [Journal]

133) Kobayashi H, Kotoura Y, Hosono M, Tsuboyama T, Sakahara H, Endo K, Konishi J.
MRI and scintigraphic features of extraabdominal desmoid tumors.
Clinical imaging. 21: 35-9, , ,. [Journal]

134) Kobayashi H, Itoh T, Shima N, Kudoh T, Shibuya K, Maekawa T, Kogawa K, Konishi J.
Periduodenal panniculitis due to spontaneous rupture of a pancreatic pseudocyst into the duodenum.
Abdominal imaging. 20: 106-8, , ,. [Journal]

135) Xu H, Regino CA, Koyama Y, Hama Y, Gunn AJ, Bernardo M, Kobayashi H, Choyke PL, Brechbiel MW.
Preparation and preliminary evaluation of a biotin-targeted, lectin-targeted dendrimer-based probe for dual-modality magnetic resonance and fluorescence imaging.
Bioconjug. Chem. 18: 1474-82, , ,. [Journal]

136) Kobayashi H, Kotoura Y, Hosono M, Tsuboyama T, Sakahara H, Konishi J.
Solitary muscular involvement by tuberculosis: CT, MRI, and scintigraphic features.
Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society. 19: 237-40, , ,. [Journal]

137) Hama Y, Koyama Y, Choyke PL, Kobayashi H.
Two-color in vivo dynamic contrast-enhanced pharmacokinetic imaging.
Journal of biomedical optics. 12: 034016, , ,. [Journal]

This page was last updated on 1/17/2008.