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NTP Experiment-Test: 88120-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99 Route: DOSED FEED Time: 12:45:07 FINAL #1 CORE STUDY RATS Facility: Battelle Columbus Laboratory Chemical CAS #: 80-07-9 Lock Date: 08/11/98 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All a Number of animals examined microscopically at site and number of animals with lesion Page 1 NTP Experiment-Test: 88120-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99 Route: DOSED FEED Time: 12:45:07 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE 0 PPM 30 PPM 100 PPM 300 PPM ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 50 50 50 50 Early Deaths Moribund Sacrifice 11 9 12 5 Natural Death 3 3 3 10 Survivors Terminal Sacrifice 36 38 34 35 Natural Death 1 Animals Examined Microscopically 50 50 50 50 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Intestine Large, Colon (50) (50) (50) (50) Parasite Metazoan 1 (2%) 1 (2%) 2 (4%) 1 (2%) Intestine Large, Rectum (50) (50) (50) (50) Parasite Metazoan 8 (16%) 4 (8%) 3 (6%) 4 (8%) Intestine Large, Cecum (50) (49) (50) (50) Inflammation 1 (2%) Intestine Small, Duodenum (50) (50) (50) (50) Ulcer 1 (2%) Liver (50) (50) (50) (50) Angiectasis 1 (2%) 1 (2%) 2 (4%) Basophilic Focus 47 (94%) 48 (96%) 43 (86%) 36 (72%) Clear Cell Focus 2 (4%) 5 (10%) 1 (2%) 2 (4%) Eosinophilic Focus 9 (18%) 10 (20%) 14 (28%) 7 (14%) Fatty Change 1 (2%) Hematopoietic Cell Proliferation 1 (2%) 1 (2%) Hemorrhage 1 (2%) Hepatodiaphragmatic Nodule 9 (18%) 11 (22%) 12 (24%) 14 (28%) Inflammation 43 (86%) 44 (88%) 39 (78%) 30 (60%) Mixed Cell Focus 8 (16%) 19 (38%) 7 (14%) 9 (18%) Necrosis 3 (6%) 1 (2%) 4 (8%) Pigmentation 1 (2%) Vacuolization Cytoplasmic 7 (14%) 11 (22%) 9 (18%) 9 (18%) Bile Duct, Hyperplasia 5 (10%) 12 (24%) 21 (42%) 32 (64%) Centrilobular, Degeneration 1 (2%) 5 (10%) 10 (20%) 7 (14%) Centrilobular, Hypertrophy 2 (4%) 24 (48%) 38 (76%) Mesentery (7) (8) (4) (4) Inflammation 2 (25%) Artery, Inflammation 1 (13%) 1 (25%) Fat, Necrosis 6 (86%) 6 (75%) 4 (100%) 3 (75%) Pancreas (50) (50) (50) (50) Atrophy 10 (20%) 8 (16%) 8 (16%) 8 (16%) Cytoplasmic Alteration 1 (2%) 1 (2%) Hyperplasia 1 (2%) 1 (2%) a Number of animals examined microscopically at site and number of animals with lesion NTP Experiment-Test: 88120-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99 Route: DOSED FEED Time: 12:45:07 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE 0 PPM 30 PPM 100 PPM 300 PPM ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - CONT Inflammation 5 (10%) 2 (4%) 7 (14%) 3 (6%) Metaplasia, Hepatocyte 1 (2%) Thrombosis 1 (2%) Artery, Inflammation 1 (2%) 1 (2%) Salivary Glands (50) (50) (50) (50) Atrophy 1 (2%) 1 (2%) 2 (4%) Cytoplasmic Alteration 1 (2%) 1 (2%) 1 (2%) Stomach, Forestomach (50) (50) (50) (50) Edema 1 (2%) Hyperplasia 1 (2%) 1 (2%) 1 (2%) 1 (2%) Inflammation 1 (2%) 1 (2%) Ulcer 2 (4%) Stomach, Glandular (50) (50) (50) (50) Erosion 2 (4%) 1 (2%) 3 (6%) Inflammation 1 (2%) 1 (2%) Mineralization 1 (2%) 1 (2%) Ulcer 3 (6%) 1 (2%) 3 (6%) Tooth (4) Inflammation 1 (25%) Peridontal Tissue, Inflammation 3 (75%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Blood Vessel (50) (50) (50) (50) Inflammation 1 (2%) Aorta, Inflammation 1 (2%) Heart (50) (50) (50) (50) Cardiomyopathy 30 (60%) 23 (46%) 23 (46%) 27 (54%) Inflammation 5 (10%) 4 (8%) 1 (2%) Thrombosis 1 (2%) 1 (2%) Valve, Inflammation 1 (2%) ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (50) (50) (50) (50) Accessory Adrenal Cortical Nodule 1 (2%) Angiectasis 27 (54%) 21 (42%) 26 (52%) 26 (52%) Degeneration, Cystic 3 (6%) 1 (2%) 2 (4%) Hyperplasia 14 (28%) 11 (22%) 19 (38%) 18 (36%) Hypertrophy 4 (8%) 4 (8%) 5 (10%) 3 (6%) Inflammation 1 (2%) Necrosis 1 (2%) 2 (4%) Vacuolization Cytoplasmic 3 (6%) 6 (12%) 5 (10%) 1 (2%) Adrenal Medulla (50) (49) (50) (50) Angiectasis 2 (4%) a Number of animals examined microscopically at site and number of animals with lesion NTP Experiment-Test: 88120-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99 Route: DOSED FEED Time: 12:45:07 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE 0 PPM 30 PPM 100 PPM 300 PPM ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - CONT Hyperplasia 4 (8%) 8 (16%) 3 (6%) 1 (2%) Pituitary Gland (50) (49) (50) (50) Angiectasis 19 (38%) 17 (35%) 23 (46%) 21 (42%) Cyst 4 (8%) 4 (8%) 3 (6%) Pars Distalis, Hyperplasia 23 (46%) 28 (57%) 23 (46%) 24 (48%) Pars Intermedia, Hyperplasia 1 (2%) Pars Nervosa, Hyperplasia 1 (2%) Thyroid Gland (50) (50) (50) (50) Angiectasis 1 (2%) Cyst 1 (2%) C-Cell, Hyperplasia 35 (70%) 38 (76%) 34 (68%) 23 (46%) Follicular Cell, Hyperplasia 1 (2%) 1 (2%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Clitoral Gland (47) (50) (50) (48) Hyperplasia 6 (13%) 6 (12%) 6 (12%) 3 (6%) Inflammation 16 (34%) 17 (34%) 21 (42%) 18 (38%) Duct, Cyst 3 (6%) 5 (10%) 2 (4%) 3 (6%) Ovary (50) (50) (50) (50) Atrophy 2 (4%) 2 (4%) 1 (2%) Cyst 3 (6%) 7 (14%) 3 (6%) 2 (4%) Infiltration Cellular, Histiocyte 2 (4%) 3 (6%) 1 (2%) Inflammation 1 (2%) Uterus (50) (50) (50) (50) Atrophy 1 (2%) Dilatation 1 (2%) Hemorrhage 1 (2%) Hydrometra 2 (4%) 4 (8%) Hyperplasia 1 (2%) Inflammation 1 (2%) 1 (2%) Cervix, Cyst, Squamous 1 (2%) 1 (2%) Cervix, Hydrometra 1 (2%) Cervix, Hyperplasia, Squamous 1 (2%) Cervix, Inflammation 1 (2%) 1 (2%) 2 (4%) Endometrium, Adenomyosis 1 (2%) Endometrium, Hyperplasia, Cystic 3 (6%) 7 (14%) 7 (14%) 6 (12%) Vagina (2) Hyperplasia 1 (50%) Inflammation 2 (100%) ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion NTP Experiment-Test: 88120-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99 Route: DOSED FEED Time: 12:45:07 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE 0 PPM 30 PPM 100 PPM 300 PPM ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Bone Marrow (50) (50) (50) (50) Atrophy 1 (2%) Hyperplasia 9 (18%) 12 (24%) 8 (16%) 12 (24%) Inflammation, Granulomatous 2 (4%) Myelofibrosis 1 (2%) Lymph Node (27) (23) (28) (28) Mediastinal, Congestion 1 (4%) Mediastinal, Ectasia 1 (4%) Mediastinal, Hyperplasia, Plasma Cell 1 (4%) Mediastinal, Pigmentation 26 (96%) 19 (83%) 26 (93%) 24 (86%) Lymph Node, Mandibular (49) (50) (48) (50) Ectasia 1 (2%) 8 (16%) 5 (10%) 5 (10%) Hyperplasia, Plasma Cell 4 (8%) 1 (2%) 5 (10%) Lymph Node, Mesenteric (50) (50) (50) (50) Atrophy 1 (2%) 1 (2%) 1 (2%) Hyperplasia, Plasma Cell 1 (2%) Spleen (50) (50) (50) (50) Accessory Spleen 1 (2%) Fibrosis 2 (4%) 1 (2%) Hematopoietic Cell Proliferation 3 (6%) 4 (8%) 7 (14%) 2 (4%) Infarct 1 (2%) Pigmentation 25 (50%) 26 (52%) 28 (56%) 32 (64%) Capsule, Fibrosis 1 (2%) Lymphoid Follicle, Atrophy 1 (2%) 1 (2%) 3 (6%) Thymus (46) (48) (50) (48) Atrophy 46 (100%) 46 (96%) 47 (94%) 48 (100%) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Mammary Gland (50) (50) (50) (50) Cyst 1 (2%) 1 (2%) Dilatation 2 (4%) Galactocele 1 (2%) 6 (12%) 1 (2%) Hyperplasia 14 (28%) 19 (38%) 20 (40%) 10 (20%) Skin (50) (50) (50) (49) Inflammation 1 (2%) Ulcer 2 (4%) Subcutaneous Tissue, Inflammation 1 (2%) ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion NTP Experiment-Test: 88120-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99 Route: DOSED FEED Time: 12:45:07 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE 0 PPM 30 PPM 100 PPM 300 PPM ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM Bone (50) (50) (50) (50) Osteopetrosis 2 (4%) 2 (4%) 6 (12%) 4 (8%) ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM Brain (50) (50) (50) (50) Hemorrhage 2 (4%) 1 (2%) Inflammation 1 (2%) Necrosis 1 (2%) ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (50) (50) (50) (50) Edema 1 (2%) Hemorrhage 1 (2%) 1 (2%) 1 (2%) Inflammation 23 (46%) 21 (42%) 23 (46%) 31 (62%) Necrosis 2 (4%) Pigmentation 40 (80%) 40 (80%) 42 (84%) 35 (70%) Thrombosis 1 (2%) 1 (2%) 1 (2%) Alveolar Epithelium, Hyperplasia 8 (16%) 7 (14%) 9 (18%) 9 (18%) Bronchiole, Hyperplasia 1 (2%) Mediastinum, Thrombosis 1 (2%) Serosa, Inflammation 1 (2%) Nose (50) (50) (50) (50) Foreign Body 2 (4%) 1 (2%) Inflammation 3 (6%) 2 (4%) 4 (8%) 4 (8%) Nasolacrimal Duct, Inflammation 1 (2%) Trachea (50) (50) (50) (50) Inflammation 1 (2%) 1 (2%) 1 (2%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM Eye (3) (2) (4) Atrophy 1 (25%) Cataract 1 (33%) 2 (100%) 3 (75%) Hemorrhage 1 (33%) 1 (25%) Cornea, Edema 1 (25%) Retina, Degeneration 1 (33%) 2 (100%) 3 (75%) ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion NTP Experiment-Test: 88120-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99 Route: DOSED FEED Time: 12:45:07 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE 0 PPM 30 PPM 100 PPM 300 PPM ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (50) (50) (50) (50) Glomerulosclerosis 1 (2%) Hydronephrosis 1 (2%) 1 (2%) Infarct 1 (2%) Inflammation 1 (2%) 1 (2%) 1 (2%) 2 (4%) Nephropathy 39 (78%) 43 (86%) 42 (84%) 42 (84%) Pigmentation 5 (10%) 2 (4%) 9 (18%) 9 (18%) Vacuolization Cytoplasmic 1 (2%) Pelvis, Inflammation 2 (4%) 1 (2%) Renal Tubule, Hyperplasia 1 (2%) Urinary Bladder (50) (50) (50) (50) Calculus Gross Observation 1 (2%) Calculus Micro Observation Only 1 (2%) Serosa, Fibrosis 1 (2%) Transitional Epithelium, Hyperplasia 1 (2%) 1 (2%) a Number of animals examined microscopically at site and number of animals with lesion NTP Experiment-Test: 88120-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99 Route: DOSED FEED Time: 12:45:07 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE 0 PPM 10 PPM 30 PPM 100 PPM ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 50 50 50 50 Early Deaths Moribund Sacrifice 19 16 24 15 Natural Death 7 4 6 7 Survivors Terminal Sacrifice 24 30 20 28 Animals Examined Microscopically 50 50 50 50 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Intestine Large, Colon (50) (50) (50) (50) Parasite Metazoan 1 (2%) 4 (8%) 1 (2%) 2 (4%) Intestine Large, Rectum (50) (50) (50) (50) Inflammation 2 (4%) Parasite Metazoan 3 (6%) 6 (12%) 8 (16%) 7 (14%) Ulcer 1 (2%) Intestine Large, Cecum (49) (50) (50) (50) Hemorrhage 1 (2%) Inflammation 1 (2%) Ulcer 1 (2%) Intestine Small, Jejunum (50) (50) (50) (50) Ulcer 1 (2%) Intestine Small, Ileum (50) (50) (50) (50) Inflammation 1 (2%) 1 (2%) Parasite Metazoan 1 (2%) Liver (50) (50) (50) (50) Angiectasis 1 (2%) Basophilic Focus 30 (60%) 29 (58%) 26 (52%) 27 (54%) Clear Cell Focus 6 (12%) 11 (22%) 2 (4%) 4 (8%) Degeneration, Cystic 5 (10%) 4 (8%) 4 (8%) 6 (12%) Eosinophilic Focus 6 (12%) 8 (16%) 6 (12%) 8 (16%) Fibrosis 1 (2%) 1 (2%) Hematopoietic Cell Proliferation 1 (2%) 1 (2%) 1 (2%) 1 (2%) Hemorrhage 1 (2%) 1 (2%) 1 (2%) Hepatodiaphragmatic Nodule 7 (14%) 5 (10%) 10 (20%) 4 (8%) Inflammation 18 (36%) 27 (54%) 19 (38%) 21 (42%) Mixed Cell Focus 7 (14%) 17 (34%) 8 (16%) 11 (22%) Necrosis 4 (8%) 1 (2%) 3 (6%) 4 (8%) Pigmentation 2 (4%) Thrombosis 1 (2%) 2 (4%) Vacuolization Cytoplasmic 9 (18%) 4 (8%) 2 (4%) 5 (10%) Bile Duct, Hyperplasia 46 (92%) 47 (94%) 44 (88%) 48 (96%) Centrilobular, Degeneration 18 (36%) 15 (30%) 20 (40%) 23 (46%) Centrilobular, Hypertrophy 1 (2%) 3 (6%) 16 (32%) a Number of animals examined microscopically at site and number of animals with lesion NTP Experiment-Test: 88120-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99 Route: DOSED FEED Time: 12:45:07 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE 0 PPM 10 PPM 30 PPM 100 PPM ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - CONT Centrilobular, Necrosis 1 (2%) 1 (2%) 1 (2%) Mesentery (7) (12) (12) (14) Hemorrhage 1 (8%) 1 (8%) Inflammation 1 (8%) 1 (8%) Necrosis 1 (14%) Fat, Inflammation 1 (14%) 1 (8%) 2 (14%) Fat, Necrosis 3 (43%) 7 (58%) 8 (67%) 7 (50%) Pancreas (50) (50) (50) (50) Atrophy 14 (28%) 14 (28%) 13 (26%) 12 (24%) Cytoplasmic Alteration 2 (4%) 2 (4%) 1 (2%) Hyperplasia 3 (6%) 2 (4%) 2 (4%) Inflammation 1 (2%) 4 (8%) 4 (8%) 2 (4%) Necrosis 1 (2%) Thrombosis 1 (2%) Artery, Inflammation 2 (4%) Duct, Cyst 1 (2%) 1 (2%) Duct, Hyperplasia 1 (2%) Salivary Glands (50) (50) (50) (50) Atrophy 1 (2%) 1 (2%) Cytoplasmic Alteration 1 (2%) 2 (4%) Duct, Hyperplasia 1 (2%) Stomach, Forestomach (50) (50) (50) (50) Edema 1 (2%) 1 (2%) 1 (2%) 1 (2%) Hyperplasia 2 (4%) 2 (4%) 1 (2%) Inflammation 1 (2%) 1 (2%) Ulcer 2 (4%) 3 (6%) 2 (4%) Stomach, Glandular (50) (50) (50) (50) Edema 1 (2%) Erosion 2 (4%) 1 (2%) 4 (8%) 3 (6%) Hyperplasia 1 (2%) Mineralization 1 (2%) 1 (2%) Necrosis 1 (2%) Ulcer 2 (4%) 2 (4%) 4 (8%) 2 (4%) Tooth (1) (1) Gingiva, Inflammation 1 (100%) Peridontal Tissue, Inflammation 1 (100%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Blood Vessel (50) (50) (50) (50) Inflammation 1 (2%) Aorta, Inflammation 1 (2%) Heart (50) (50) (50) (50) Cardiomyopathy 39 (78%) 46 (92%) 43 (86%) 43 (86%) Inflammation 1 (2%) Thrombosis 1 (2%) 5 (10%) 5 (10%) 2 (4%) a Number of animals examined microscopically at site and number of animals with lesion NTP Experiment-Test: 88120-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99 Route: DOSED FEED Time: 12:45:07 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE 0 PPM 10 PPM 30 PPM 100 PPM ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM - CONT Artery, Inflammation 1 (2%) Endocardium, Degeneration 1 (2%) Epicardium, Hyperplasia 1 (2%) ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (50) (50) (50) (50) Angiectasis 2 (4%) 1 (2%) 2 (4%) 1 (2%) Atrophy 1 (2%) Degeneration, Cystic 1 (2%) 1 (2%) Hematopoietic Cell Proliferation 1 (2%) Hyperplasia 11 (22%) 13 (26%) 8 (16%) 9 (18%) Hypertrophy 3 (6%) 7 (14%) 3 (6%) 2 (4%) Necrosis 2 (4%) Vacuolization Cytoplasmic 8 (16%) 6 (12%) 4 (8%) 3 (6%) Adrenal Medulla (50) (50) (50) (50) Hemorrhage 1 (2%) Hyperplasia 14 (28%) 10 (20%) 15 (30%) 12 (24%) Infiltration Cellular, Lymphocyte 1 (2%) Islets, Pancreatic (50) (50) (50) (50) Hyperplasia 1 (2%) 1 (2%) Parathyroid Gland (46) (48) (47) (46) Hyperplasia, Focal 1 (2%) Pituitary Gland (50) (50) (50) (50) Angiectasis 7 (14%) 6 (12%) 6 (12%) 3 (6%) Cyst 2 (4%) 8 (16%) 10 (20%) 6 (12%) Hemorrhage 1 (2%) 2 (4%) Pars Distalis, Hyperplasia 15 (30%) 17 (34%) 21 (42%) 15 (30%) Pars Distalis, Pseudocyst 6 (12%) 1 (2%) Pars Intermedia, Cyst 1 (2%) Pars Intermedia, Hyperplasia 1 (2%) Pars Intermedia, Pseudocyst 3 (6%) Thyroid Gland (50) (50) (50) (50) Inflammation 1 (2%) C-Cell, Hyperplasia 19 (38%) 30 (60%) 26 (52%) 20 (40%) Follicular Cell, Hyperplasia 3 (6%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion NTP Experiment-Test: 88120-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99 Route: DOSED FEED Time: 12:45:07 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE 0 PPM 10 PPM 30 PPM 100 PPM ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Epididymis (50) (50) (50) (50) Hyperplasia 1 (2%) 1 (2%) Inflammation 1 (2%) 1 (2%) Mesothelium, Hyperplasia 1 (2%) 1 (2%) Preputial Gland (50) (50) (50) (50) Hyperplasia 4 (8%) 2 (4%) Inflammation 46 (92%) 45 (90%) 48 (96%) 48 (96%) Duct, Cyst 3 (6%) 2 (4%) 2 (4%) Prostate (50) (50) (50) (50) Cyst 1 (2%) Inflammation 27 (54%) 38 (76%) 31 (62%) 29 (58%) Dorsal, Cyst, Mucous 1 (2%) 1 (2%) 1 (2%) Seminal Vesicle (50) (50) (50) (50) Atrophy 1 (2%) Inflammation 1 (2%) 1 (2%) Testes (50) (50) (50) (50) Atrophy 5 (10%) 7 (14%) 3 (6%) 6 (12%) Cyst 1 (2%) Hyperplasia 1 (2%) Artery, Inflammation 1 (2%) Interstitial Cell, Hyperplasia 28 (56%) 37 (74%) 28 (56%) 24 (48%) Mesothelium, Hyperplasia 1 (2%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Bone Marrow (50) (50) (50) (50) Hyperplasia 18 (36%) 18 (36%) 16 (32%) 20 (40%) Inflammation, Granulomatous 1 (2%) Myelofibrosis 4 (8%) 2 (4%) 1 (2%) 2 (4%) Necrosis 1 (2%) 1 (2%) Lymph Node (15) (11) (14) (14) Inguinal, Hyperplasia, Plasma Cell 1 (9%) Mediastinal, Atrophy 1 (9%) Mediastinal, Ectasia 1 (9%) Mediastinal, Hemorrhage 1 (7%) Mediastinal, Necrosis 1 (7%) Mediastinal, Pigmentation 4 (27%) 1 (9%) 4 (29%) 3 (21%) Pancreatic, Necrosis 1 (9%) Renal, Hyperplasia, Plasma Cell 1 (7%) Renal, Necrosis 1 (7%) Lymph Node, Mandibular (50) (50) (49) (50) Ectasia 3 (6%) 5 (10%) 3 (6%) 2 (4%) Hyperplasia, Plasma Cell 4 (8%) 1 (2%) Necrosis 1 (2%) 1 (2%) Lymph Node, Mesenteric (50) (50) (50) (49) a Number of animals examined microscopically at site and number of animals with lesion NTP Experiment-Test: 88120-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99 Route: DOSED FEED Time: 12:45:07 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE 0 PPM 10 PPM 30 PPM 100 PPM ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - CONT Atrophy 1 (2%) 1 (2%) Ectasia 1 (2%) 1 (2%) Hyperplasia, Reticulum Cell 2 (4%) Necrosis 1 (2%) 1 (2%) Spleen (50) (50) (50) (50) Accessory Spleen 1 (2%) 1 (2%) 2 (4%) Fibrosis 2 (4%) 4 (8%) 4 (8%) 5 (10%) Hematopoietic Cell Proliferation 4 (8%) 5 (10%) 3 (6%) 5 (10%) Hyperplasia, Lymphoid 1 (2%) Hyperplasia, Reticulum Cell 1 (2%) 1 (2%) Hyperplasia, Stromal 1 (2%) Infarct 1 (2%) 1 (2%) 1 (2%) Infiltration Cellular, Lipocyte 1 (2%) Necrosis 1 (2%) 1 (2%) Pigmentation 1 (2%) 2 (4%) 2 (4%) 1 (2%) Lymphoid Follicle, Atrophy 2 (4%) 3 (6%) 2 (4%) Thymus (46) (47) (46) (47) Atrophy 44 (96%) 45 (96%) 40 (87%) 43 (91%) Artery, Inflammation 1 (2%) Epithelial Cell, Hyperplasia 1 (2%) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Mammary Gland (47) (50) (48) (50) Cyst 1 (2%) 1 (2%) Galactocele 2 (4%) Hyperplasia 2 (4%) 8 (16%) 9 (19%) 6 (12%) Inflammation 1 (2%) 1 (2%) Skin (50) (50) (50) (50) Cyst Epithelial Inclusion 1 (2%) Edema 1 (2%) Fibrosis 1 (2%) Hyperkeratosis 1 (2%) 1 (2%) Hyperplasia 1 (2%) 1 (2%) Inflammation 1 (2%) 1 (2%) 1 (2%) Ulcer 1 (2%) 1 (2%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM Bone (50) (50) (50) (50) Osteopetrosis 1 (2%) 1 (2%) 1 (2%) ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion NTP Experiment-Test: 88120-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99 Route: DOSED FEED Time: 12:45:07 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE 0 PPM 10 PPM 30 PPM 100 PPM ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM Brain (50) (50) (50) (50) Gliosis 1 (2%) 1 (2%) Hemorrhage 2 (4%) 1 (2%) 4 (8%) 3 (6%) Necrosis 1 (2%) 4 (8%) Thrombosis 1 (2%) Spinal Cord (1) Hemorrhage 1 (100%) ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (50) (50) (50) (50) Edema 1 (2%) 1 (2%) Foreign Body 1 (2%) 1 (2%) 1 (2%) Hemorrhage 2 (4%) 3 (6%) 4 (8%) Inflammation 11 (22%) 16 (32%) 14 (28%) 18 (36%) Inflammation, Granulomatous 1 (2%) Necrosis 1 (2%) 1 (2%) Pigmentation 1 (2%) Thrombosis 1 (2%) 1 (2%) 2 (4%) Alveolar Epithelium, Hyperplasia 9 (18%) 7 (14%) 2 (4%) 5 (10%) Nose (50) (50) (50) (50) Foreign Body 5 (10%) 6 (12%) 3 (6%) 5 (10%) Inflammation 12 (24%) 9 (18%) 6 (12%) 8 (16%) Trachea (50) (50) (50) (50) Inflammation 1 (2%) 1 (2%) 1 (2%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM Eye (1) (1) (1) Cataract 1 (100%) 1 (100%) Retina, Degeneration 1 (100%) 1 (100%) ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (50) (50) (50) (50) Infarct 1 (2%) 1 (2%) 3 (6%) 1 (2%) Inflammation 2 (4%) Necrosis 2 (4%) Nephropathy 42 (84%) 48 (96%) 41 (82%) 44 (88%) Pigmentation 13 (26%) 4 (8%) 15 (30%) 19 (38%) Thrombosis 1 (2%) Artery, Inflammation 1 (2%) Pelvis, Inflammation 1 (2%) a Number of animals examined microscopically at site and number of animals with lesion NTP Experiment-Test: 88120-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC P,P'-DICHLORODIPHENYL SULFONE Date: 10/27/99 Route: DOSED FEED Time: 12:45:07 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE 0 PPM 10 PPM 30 PPM 100 PPM ____________________________________________________________________________________________________________________________________ URINARY SYSTEM - CONT Renal Tubule, Degeneration 1 (2%) Urethra (1) Inflammation 1 (100%) Urinary Bladder (50) (50) (50) (50) Inflammation 2 (4%) Transitional Epithelium, Hyperplasia 2 (4%) a Number of animals examined microscopically at site and number of animals with lesion ------------------------------------------------------------ ---------- END OF REPORT ---------- 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