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UGID:199215     UniGene Hs.371350     Homo sapiens (human)   HLCS Order cDNA clone, Links
HCS (HLCS)
SELECTED PROTEIN SIMILARITIES
Comparison of sequences in UniGene with selected protein reference sequences. The alignments can suggest function of a gene.
Reference ProteinSpeciesId(%)Len(aa)
NP_000402.3 holocarboxylase synthetase H. sapiens 100.0 725
XP_531454.2 PREDICTED: holocarboxylase synthetase P. troglodytes 99.7 872
NP_631884.1 holocarboxylase synthetase M. musculus 81.9 721

GENE EXPRESSION
Tissues and development stages from this gene's sequences survey gene expression. Links to other NCBI expression resources.
EST Profile: Approximate expression patterns inferred from EST sources.
[Show more entries with profiles like this]
GEO profiles: Experimental gene expression data (Gene Expression Omnibus).
cDNA Sources: brain; uncharacterized tissue; muscle; mammary gland; testis; mixed; connective tissue; placenta; cervix; lung; embryonic tissue; intestine; uterus; esophagus; prostate; amniotic fluid; eye; thyroid; vascular; stomach; pituitary gland; trachea; bone; larynx; skin; kidney; pancreas; heart; lymph node; bone marrow; mouth; blood; ovary; liver; nerve; parathyroid; adrenal gland
MAPPING POSITION
Genomic location specified by transcript mapping, radiation hybrid mapping, genetic mapping or cytogenetic mapping.
Chromosome: 21
Map position: 21q22.1|21q22.13
UniSTS entry: Chr 21 SHGC-12620
UniSTS entry: Chr 21 SHGC-87611
UniSTS entry: Chr 21 SHGC-52086
UniSTS entry: Chr 21 WI-15188
UniSTS entry: Chr 21 SHGC-53043
UniSTS entry: Chr 21 SHGC-52136
UniSTS entry: Chr 21 SHGC-87607
UniSTS entry: Chr Y D11S2921
SEQUENCES
Sequences representing this gene; mRNAs, ESTs, and gene predictions supported by transcribed sequences.

mRNA sequences (8)

NM_000411.4 Homo sapiens holocarboxylase synthetase (biotin-(proprionyl-Coenzyme A-carboxylase (ATP-hydrolysing)) ligase) (HLCS), mRNA PA
BC060787.1 Homo sapiens holocarboxylase synthetase (biotin-(proprionyl-Coenzyme A-carboxylase (ATP-hydrolysing)) ligase), mRNA (cDNA clone MGC:71574 IMAGE:30343493), complete cds PA
D23672.2 Homo sapiens mRNA for holocarboxylase synthetase, complete cds P
AK314189.1 Homo sapiens cDNA, FLJ94913, highly similar to Homo sapiens holocarboxylase synthetase(biotin-[proprionyl-Coenzyme A-carboxylase (ATP-hydrolysing)]ligase) (HLCS), mRNA P
AK307940.1 Homo sapiens cDNA, FLJ97888 P
AJ001864.1 Homo Sapiens mRNA, partial cDNA sequence for holocarboxylase synthetase, DCR1-9.0 P
X80160.1 H.sapiens HCS mRNA P
D87328.1 Homo sapiens mRNA for HCS, complete cds P

EST sequences (214)

AA993715.1 Clone IMAGE:1619994 testis 3' read A
AI024975.1 Clone IMAGE:1639700 testis 3' read A
AI041363.1 Clone IMAGE:1648154 parathyroid 3' read
AA946983.1 Clone IMAGE:1589290 kidney 3' read A
AI075253.1 Clone IMAGE:1671102 uncharacterized tissue 3' read
AI089425.1 Clone IMAGE:1685834 brain 3' read
AI089461.1 Clone IMAGE:1695456 uterus 3' read A
AI093337.1 Clone IMAGE:1695093 uterus 3' read
AA947981.1 Clone IMAGE:1508555 mixed 3' read A
CB049233.1 Clone IMAGE:3271374 prostate 3' read A
CB049234.1 Clone IMAGE:3271374 prostate 5' read
AI148632.1 Clone IMAGE:1714227 placenta 3' read A
AI160922.1 Clone IMAGE:1715632 placenta 3' read A
AI249912.1 Clone IMAGE:2000818 lymph node 3' read A
CB127576.1 Clone C1SNU17-21-F10 cervix 5' read
CB150727.1 Clone C1SNU17-34-E06 cervix 5' read
AA908400.1 Clone IMAGE:1454332 ovary 3' read A
AI423055.1 Clone IMAGE:2097851 brain 3' read A
AI471680.1 Clone IMAGE:2155211 intestine 3' read A
AI702836.1 Clone IMAGE:2340471 lung 3' read
AI741186.1 Clone IMAGE:2366200 mixed 3' read A
AI753201.1 Clone HBMSC_cr06h02 bone marrow 3' read A
AI753884.1 Clone HBMSC_cr15e06 bone marrow 3' read A
CB529960.1 Clone UI-H-FT2-bji-l-15-0-UI lung 3' read PA
AI864964.1 Clone IMAGE:2411498 lymph node 3' read A
AI889556.1 Clone IMAGE:2437957 uterus 3' read A
AL042600.1 Clone DKFZp434K0921 testis 5' read P
AL043776.1 Clone DKFZp434O2327 testis 5' read
AL043777.2 Clone DKFZp434O2327 testis 3' read
CB988654.1 Clone IMAGE:30343493 placenta 5' read P
CD102840.1 Clone IMAGE:30373175 mixed 5' read
AW014529.1 Clone IMAGE:2709728 uncharacterized tissue 3' read A
BX474953.1 Clone DKFZp686I04173 muscle 5' read P
AW024694.1 Clone IMAGE:2525210 kidney 3' read A
CD742796.1 Clone UI-H-FT2-bjq-d-16-0-UI lung 3' read PA
AW084798.1 Clone IMAGE:2588925 esophagus 3' read
AW136725.1 Clone IMAGE:2717108 mixed 3' read
AW193771.1 Clone IMAGE:2685688 uncharacterized tissue 3' read
AI906952.1 mammary gland
AW241332.1 Clone IMAGE:2570674 connective tissue 3' read
F13052.1 Clone c-3ia06 brain
F10644.1 Clone c-3ia06 brain 3' read A
AW273476.1 Clone IMAGE:2762609 uterus 3' read A
AW298725.1 Clone IMAGE:2732760 uncharacterized tissue 3' read
CD608433.1 uncharacterized tissue
CD608434.1 uncharacterized tissue
CD608435.1 uncharacterized tissue
CD608436.1 uncharacterized tissue
CD608437.1 uncharacterized tissue
CD608438.1 uncharacterized tissue
CD608439.1 uncharacterized tissue
CD608440.1 uncharacterized tissue
CD608441.1 uncharacterized tissue
CD608430.1 uncharacterized tissue
CD608431.1 uncharacterized tissue
CD608432.1 uncharacterized tissue
CD608442.1 uncharacterized tissue
CD608443.1 uncharacterized tissue
AW629864.1 Clone IMAGE:2968300 mixed 5' read P
AW951030.1 uncharacterized tissue P
AW958293.1 uncharacterized tissue
CN357667.1 embryonic tissue 5' read P
CN357668.1 embryonic tissue 5' read
CN357669.1 embryonic tissue 5' read P
CN357670.1 embryonic tissue 5' read
CN357671.1 embryonic tissue 5' read
CN357672.1 embryonic tissue 5' read
H17102.1 Clone IMAGE:50365 brain 3' read A
H17720.1 Clone IMAGE:50365 brain 5' read
BE218432.1 Clone IMAGE:3175724 lung 3' read
BP271960.1 Clone KAT02313 stomach 5' read P
BP335488.1 Clone SMR01468 vascular 5' read
BP350237.1 Clone SZR08351 brain 5' read P
BP350241.1 Clone SZR08450 brain 5' read P
BE503952.1 Clone IMAGE:3211648 lung 3' read
BE671228.1 Clone IMAGE:3286393 lung 3' read
BE673005.1 Clone IMAGE:3248385 prostate 3' read A
H45392.1 Clone IMAGE:176590 brain 5' read P
H45393.1 Clone IMAGE:176590 brain 3' read
BE708069.1 thyroid
BE708423.1 thyroid
BP391205.1 Clone h-t-239-23 pancreas 3' read
CX866758.1 Clone IMAGE:7472379 embryonic tissue 3' read A
CX866839.1 Clone IMAGE:7472379 embryonic tissue 5' read
BE768726.1 prostate
DN996277.1 Clone TC119915 mammary gland 5' read P
BE934140.1 larynx
BE939702.1 uterus
R99085.1 Clone IMAGE:201397 mixed 3' read A
BF089530.1 larynx
R99628.1 Clone IMAGE:201397 mixed 5' read
AV750854.1 Clone NPCBID06 pituitary gland 5' read
AU125473.1 Clone NT2RM4001652 testis 5' read P
AU125648.1 Clone NT2RM4001959 testis 5' read P
AU129557.2 Clone NT2RP2005785 testis 5' read
BF224167.1 Clone IMAGE:3704929 lung 3' read
BF229259.1 amniotic fluid P
AA722899.1 Clone IMAGE:409795 heart 3' read
BF671778.1 Clone IMAGE:4292915 muscle 5' read
DA274080.1 Clone BRCOC2000346 brain 5' read P
DA346580.1 Clone BRSSN2007698 brain 5' read
DA241621.1 Clone BRAWH3039447 brain 5' read P
DA170061.1 Clone BRAMY2032027 brain 5' read
DA206566.1 Clone BRAWH2013360 brain 5' read P
DA135772.1 Clone BRALZ2008832 brain 5' read
DA102762.1 Clone BRACE3015473 brain 5' read P
DA097639.1 Clone BRACE3008335 brain 5' read P
DA221538.1 Clone BRAWH3013610 brain 5' read P
DA334377.1 Clone BRHIP3033728 brain 5' read P
DA217563.1 Clone BRAWH3008485 brain 5' read P
DA297303.1 Clone BRHIP2010555 brain 5' read
DA264095.1 Clone BRCAN2016964 brain 5' read
DA232531.1 Clone BRAWH3028132 brain 5' read P
H69546.1 Clone IMAGE:212472 mixed 3' read
H70003.1 Clone IMAGE:212472 mixed 5' read
DA410801.1 Clone BRTHA3017695 brain 5' read P
DA404459.1 Clone BRTHA3008968 brain 5' read P
DA557873.1 Clone HCHON2008634 connective tissue 5' read P
BF063029.1 Clone IMAGE:3321751 intestine 3' read P
DA408147.1 Clone BRTHA3014040 brain 5' read
AU143539.1 Clone Y79AA1002087 eye 5' read P
AU149128.1 Clone NT2RM4001652 testis 3' read
AU149261.1 Clone NT2RM4001959 testis 3' read
DA417132.1 Clone BRTHA3026553 brain 5' read P
AU151653.1 Clone NT2RP2005785 testis 3' read A
DA922483.1 Clone SMINT2008488 intestine 5' read P
BF435269.1 Clone IMAGE:3267857 mixed 3' read A
BF435733.1 Clone IMAGE:3268129 mixed 3' read A
DA858766.1 Clone PLACE7010432 placenta 5' read P
DA714809.1 Clone NT2RI2021909 5' read P
DA715549.1 Clone NT2RI2022867 5' read P
DA755010.1 Clone NT2RP8001197 testis 5' read P
DA755966.1 Clone NT2RP8002526 testis 5' read P
DB258861.1 Clone UTERU2015572 uterus 5' read
DB194634.1 Clone TRACH1000338 trachea 5' read P
DB320609.1 Clone KIDNE2005583 kidney 3' read
DB290499.1 Clone UTERU3020535 uterus 5' read P
DB254326.1 Clone UTERU2009249 uterus 5' read P
BF760093.1 intestine P
BF760381.1 intestine
DB223468.1 Clone TRACH3014786 trachea 5' read P
DB178862.1 Clone TKIDN2016189 kidney 5' read P
BF808457.1 intestine
BG028622.1 Clone IMAGE:4387722 bone 5' read
BF976809.1 Clone IMAGE:4305466 skin 5' read
BF939200.1 Clone IMAGE:3410249 prostate 3' read A
BF944988.1 brain
H99324.1 Clone IMAGE:262547 skin 3' read
BG055010.1 Clone IMAGE:3442038 brain 3' read A
DB536760.1 Clone H023036O18 brain 3' read A
DB469252.1 Clone H023036O18 brain 5' read P
BG251873.1 Clone IMAGE:4472782 liver 5' read
N26429.1 Clone IMAGE:262543 skin 5' read P
N31481.1 Clone IMAGE:272156 skin 3' read A
EC530443.1 prostate
N42790.1 Clone IMAGE:272156 skin 5' read
BG546550.1 Clone IMAGE:4702465 lung 5' read
BG200707.1 connective tissue PA
BG210738.1 connective tissue A
BG742806.1 Clone IMAGE:4777861 skin 5' read
BI094308.1 Clone IMAGE:5001456 placenta 5' read
BG959316.1 intestine
EL734116.1 mixed 5' read P
DC333804.1 Clone BRHIP3016177 brain 5' read P
DC363327.1 Clone MESAN2002927 kidney 5' read P
DC346222.1 Clone CTONG2012163 mouth 5' read P
DC307332.1 Clone BRACE3010845 brain 5' read P
DC322133.1 Clone BRAWH3017752 brain 5' read P
T49667.1 Clone IMAGE:67798 placenta 5' read
BM044748.1 Clone IMAGE:5447974 prostate 5' read P
W17009.1 Clone IMAGE:301561 lung 5' read
BM562444.1 Clone IMAGE:5745660 blood 5' read
BM670849.1 Clone UI-E-DW1-ahd-l-06-0-UI eye 3' read A
BI481498.1 eye 5' read
BM693706.1 Clone UI-E-DW1-ahd-l-06-0-UI eye 5' read A
BM986873.1 Clone IMAGE:3104134 uncharacterized tissue 3' read A
BQ008499.1 Clone IMAGE:5839826 connective tissue 3' read PA
BQ029577.1 Clone IMAGE:5866889 connective tissue 3' read A
AA021215.1 Clone IMAGE:364156 eye 3' read P
AA029413.1 Clone IMAGE:366800 heart 3' read A
AA029279.1 Clone IMAGE:366800 heart 5' read
BQ717432.1 Clone IMAGE:6194111 nerve 5' read P
BQ721020.1 Clone IMAGE:6189829 nerve 5' read
BQ775124.1 Clone UI-H-FH0-bci-b-15-0-UI bone 3' read A
BM930024.1 Clone UI-E-EJ1-ajj-i-03-0-UI eye 5' read P
AA053462.1 Clone IMAGE:510193 intestine 3' read A
AA053214.1 Clone IMAGE:510193 intestine 5' read P
AA054694.1 Clone IMAGE:509882 intestine 5' read
BU428980.1 Clone IMAGE:3063938 lymph node 5' read
BU542434.1 Clone IMAGE:6574293 prostate 5' read P
AA148605.1 Clone IMAGE:502991 uterus 5' read
AA148606.1 Clone IMAGE:502991 uterus 3' read
AA194681.1 Clone IMAGE:628910 muscle 5' read
AA224566.1 Clone IMAGE:663633 testis 3' read A
AA227361.1 Clone IMAGE:663633 testis 5' read
BU743224.1 Clone UI-E-EJ1-ajj-i-03-0-UI eye 3' read PA
AA256749.1 Clone IMAGE:685918 lymph node 5' read P
AA262507.1 Clone IMAGE:685918 lymph node 3' read P
CA312137.1 Clone UI-CF-FN0-afj-n-17-0-UI lung 3' read A
T75293.1 Clone IMAGE:23232 brain 5' read
CA428788.1 Clone UI-H-FH1-bfe-h-15-0-UI bone 3' read PA
AA310904.1 blood 5' read
AA311778.1 blood 5' read P
AA421596.1 Clone IMAGE:739302 ovary 3' read A
AA421601.1 Clone IMAGE:739326 ovary 3' read A
AA450362.1 Clone IMAGE:785620 embryonic tissue 3' read P
AA449006.1 Clone IMAGE:785620 embryonic tissue 5' read P
AA455043.1 Clone IMAGE:812246 mixed 3' read A
AA573074.1 Clone IMAGE:1071672 mammary gland 3' read A
AA604170.1 Clone IMAGE:1112081 adrenal gland 3' read
AA776390.1 Clone IMAGE:1156858 kidney 3' read
AA788759.1 Clone 1240369 parathyroid 3' read A
AA918071.1 Clone IMAGE:1535997 kidney 3' read P
AA953568.1 Clone IMAGE:1554982 kidney 3' read A


Key to Symbols

P Has similarity to known Proteins (after translation)
A Contains a poly-Adenylation signal
S Sequence is a Suboptimal member of this cluster
M Clone is putatively CDS-complete by MGC criteria

 
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