Ajana F, Senneville E, Valette M, Bourez JM, Chidiac C, Mouton Y; International Conference on AIDS.
Int Conf AIDS. 1996 Jul 7-12; 11: 17 (abstract no. We.B.112).
Service des Maladies Infectieuses, Tourcoing, France.
Objectives: 19 HIV-infected patients and presenting idiopathic thrombocytopenia were follow up on clinical and biological level. 9 patients were splenectomized after failure of Retrovir, steroids and IVIG. The other 10 patients refused splenectomy. Polysaccharide vaccine "pneumo 23" was performed in the whole patients and chemoprophylaxis "penicillin" was prescribed and well observed in the 9 splenectomized patients. Results: (table: see text) All the patients were at an early stage of their immunodeficiency. The splenectomy made the correction of the thrombocytopenia possible during 19, 18 months mean duration period. Nevertheless, recurrence concerned 6 of 9 patients. The rate of CD4 is noticed higher in splenectomized patients. 7 pneumococcal infections are noticed in the splenectomized patients. Conclusion: We confirm, in this study, a high risk of severe pneumococcal infections after splenectomy, and a transient effect on the thrombocytopenia. The benign nature of idiopathic thrombocytopenia, and the non efficient anti-pneumococcal infections prophylaxis, might temperate the indication of splenectomy in HIV patients?
Publication Types:
Keywords:
- AIDS Vaccines
- Acquired Immunodeficiency Syndrome
- Antigens, CD4
- HIV Infections
- HIV Seropositivity
- Humans
- Immunoglobulins, Intravenous
- Penicillins
- Pneumococcal Infections
- Purpura, Thrombocytopenic, Idiopathic
- Splenectomy
- Thrombocytopenia
- Zidovudine
- immunology
- surgery
Other ID:
UI: 102219069
From Meeting Abstracts