Dr Ronen Rubinshtein
Department of Cardiovascular Medicine, Lady Davis Carmel Medical Center, 7 Michal Street, Haifa 34362, Israel; adironen/at/netvision.net.il
Patient 1 is a 66 year old male who presented with acute anterior STEMI. Alteplase treatment resulted in successful reperfusion. The patient later mentioned a history of known pituitary adenoma for which surgery was planned. Seven days later he underwent angioplasty to the left anterior descending coronary artery for recurrent ischaemia/infarction.
Patient 2 is a 77 year old female with acute extensive anterior STEMI who was treated with streptokinase without signs of reperfusion and subsequently underwent successful angioplasty to the left anterior descending coronary artery. She later acknowledged the existence of an intracranial meningioma.
Computerised tomography confirmed the presence of ICT in both patients, without evidence of bleeding. The size of the pituitary adenoma in patient 1 was 1.8 × 1.5 × 1.2 cm and the size of the meningioma in patient 2 was 0.7 × 0.8 × 0.8 cm.
ICTs are found in 1–2% of all necropsies.4 In the GUSTO-1 study, which enrolled 41 021 patients, 244 cases of thrombolysis related ICH were systematically investigated with computerised tomography.5 Despite the statistical likelihood that approximately 1% of the participants had ICT, no such cases were reported in conjunction with ICH. It is possible, however, that in the case of a small tumour and a large bleed, the original pathology may have been difficult to identify. We suggest that thrombolysis be considered in selected patients with acute extensive (especially anterior) STEMI and coincidental non-infiltrating ICT, particularly when urgent primary angioplasty is not available.
One should consider the significant mortality reduction achieved with thrombolysis for acute myocardial infarction (up to 50%) and the data from the thrombolytic mega-trials that did not identify asymptomatic ICT as a risk factor for ICH. The low ICH rate and the significant benefit of thrombolytic treatment reported in real life patients with STEMI who have contraindications to that therapy might also support our hypothesis.1 On the other hand, thrombolysis should probably be avoided in patients with ICT and a small (inferior), low risk STEMI.