US 7,348,314 B2
	Compositions and methods for inhibiting viral replication
Matthias John, Hallstadt (Germany); Stefan Limmer, Neudrossenfeld (Germany); Hans-Peter Vornlocher, Bayreuth (Germany); and Roland Kreutzer, Weidenberg (Germany)
Assigned to Alnylam Europe AG, Kulmbach (Germany)
Filed on Mar. 07, 2003, as Appl. No. 10/384,512.
Application 10/384512 is a continuation in part of application No. PCT/EP02/11432, filed on Oct. 11, 2002.
Claims priority of application No. 101 50 187 (DE), filed on Oct. 12, 2001; application No. 101 55 280 (DE), filed on Oct. 26, 2001; application No. 101 58 411 (DE), filed on Nov. 29, 2001; application No. 101 60 151 (DE), filed on Dec. 07, 2001; and application No. 101 63 098 (DE), filed on Dec. 20, 2001.
Prior Publication US 2004/0091457 A1, May 13, 2004
Int. Cl. A61K 31/70 (2006.01); C07H 21/04 (2006.01); C07H 21/00 (2006.01)

U.S. Cl. 514—44  [536/24.5; 536/25.3]

3 Claims

1. A method for inhibiting the replication of hepatitis C virus in a hepatitis C virus infected cell in vitro, which comprises introducing a double-stranded ribonucleic acid (dsRNA) into the cell, wherein the dsRNA comprises a sense RNA strand consisting of SEQ ID No. 4 and an antisense strand consisting of SEQ ID NO:5.