Cancer Control Research
1R01CA021016-01
PI Name is not available.
NUTRITIVE QUALITY OF DIETARY FIBERS FOR HUMANS
AbstractThe principal objective of this study is to test the non-nutritive character of
dietary fiber and the infuence of fiber on fecal composition in humans. Two
dietary sources of fiber, wheat bran and brussel sprouts are to be compared in
digestion balance, and the bioavailablity of minerals, water soluble vitamins
measured and also the digestibility of the two fiber sources in an 81 day
experiment with 12 male human subjects. The biological degradability of cereal
and vegetable fibers by human fecal bacteria; rumen bacteria and cellulase
enzymes will be compared and the capacity of fecal and rumen cultures to alter
potential carcinogenic substances measured in vitro. The problem of fiber
determination will be investigated by comparing the chemical composition and
physical properties of cereal, vegetable and fecal fiber and to use these
observations to compare the validity of various methods for determination of
food fiber, including AOAC crude fiber, detergent fibers and non-nutritive
residues. The recovery of plant cell wall components, cellulose, hemicellulose,
lignin and pectin and foreign matter in the residue obtained by the digestive
methods will be determined. Transit measurements will be made with particulate
and liquid markers to test the effect of fibers upon transit time, capacity, and
surface exchange properties as well as the characteristics of various markers.
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