DAVID: Database for Annotation, Visualization, and Integrated Discovery (Laboratory of Immunopathogenesis and Bioinformatics (LIB); National Institute of Allergies and Infectious Diseases (NIAID); Science Applications International Corporation (SAIC)

DAVID Gene Report

Gene Report

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144575	nudix (nucleoside diphosphate linked moiety x)-type motif 4	Related Genes	Mus musculus
SP_COMMENT	catalytic activity:Diphospho-myo-inositol polyphosphate + H(2)O = myo-inositol polyphosphate + phosphate., cofactor:Magnesium or manganese., function:Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), PP-InsP4 and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphate Ap6A, but not Ap5A. The major reaction products are ADP and p4a from Ap6A. Also able to hydrolyze PRPP (5-phosphoribosyl 1-pyrophosphate)., similarity:Belongs to the Nudix hydrolase family., similarity:Belongs to the Nudix hydrolase family. DIPP subfamily., subcellular location:Cytoplasm.,
REFSEQ_PROTEIN	NP_081998,
REFSEQ_MRNA	NM_027722,
GENPEPT_ACCESSION	AAH27209, BAB30582, BAC33229, CAJ18550, EDL21610, EDL21611, mRNA,
GENE_SYMBOL	NUDT4,
GENE_NAME	DIPP-2, Diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 2, Diphosphoinositol polyphosphate phosphohydrolase 2, Diphosphoinositol polyphosphate phosphohydrolase 2 (EC 3.6.1.52) (DIPP-2) (Diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 2) (EC 3.6.1.-) (Nucleoside diphosphate-linked moiety X motif 4) (Nudix motif 4), Nucleoside diphosphate-linked moiety X motif 4, Nudix motif 4, Nudt4 protein, nudix (nucleoside diphosphate linked moiety X)-type motif 4,
CHROMOSOME	10,
ENTREZ_GENE_ID	71207,
PIR_SUMMARY	Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), PP-InsP4 and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphate Ap6A, but not Ap5A. The major reaction products are ADP and p4a from Ap6A. Also able to hydrolyze PRPP (5-phosphoribosyl 1-pyrophosphate) (By similarity).,
EC_NUMBER	3.6.1.-, 3.6.1.52,
UNIGENE	Mm.24397, Mm.435793, Mm.467693,
PIR_NREF_ID	NF00535011, NF00959442, NF01181056,
UNIREF100_ID	UniRef100_Q8R2U6,
UNIPROT_ID	NUDT4_MOUSE, Q4FJR0_MOUSE,

Please cite the web site or Genome Biology 2003; 4(5):P3 within any publication that makes use of any methods inspired by DAVID.


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