pmc logo imageJournal ListSearchpmc logo image
Logo of jammchemJournal's HomeManuscript SubmissionAims and ScopeAuthor GuidelinesEditorial BoardHome
J Autom Methods Manag Chem. 2002; 24(1): 17–24.
doi: 10.1155/S1463924602000032.
PMCID: PMC2562956
To robotize chemistry laboratories. An example of organic synthesis: 2-Boc-amino-N-hydroxy-3-phenyl-propionamide
G. Christophe,1 L. Chapelant,1 S. Bostyn,1 C. Porte,corresponding author1 A. Delacroix,1 and H. D'Orchymont2
1 Equipe EA 21: Laboratoire de Chimie Industrielle du Conservatoire National des Arts et Métiers et Laboratoire de Productique chimique de l'IUT d'Orléans, 2 rue Conté, Paris Cedex 3, F-75141, France,
2 Synthélabo Biomoléculaire, 16 rue d'Ankara, Strasbourg Cedex, F-67080, France,
C. Porte, Email: cporte/at/cnam.fr.
corresponding authorCorresponding author.
Abstract
The paper describes the development of periodic modules used for the peptide synthesis of hydroxamic acid. A powder conveyor using the principle of positive weighing distribution is described. Purification is provided using automatic filtration and a liquid— liquid extraction module separation device. Device quality is improved using failure mode and effects analysis.