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9	Bronchiolitis obliterans in workers exposed to flavoring chemicals
Authors	Kanwal-R
Source	Curr Opin Pulm Med 2008 Mar; 14(2):141-146
Link	http://www.co-pulmonarymedicine.com/pt/re/copulmonary/abstract.00063198-200803000-00011.htm
NIOSHTIC No.	20033274
Abstract	Purpose of review: Medical and environmental surveys at microwave popcorn plants and flavoring production plants have revealed a risk for bronchiolitis obliterans in workers exposed to flavoring chemicals. Workers in other food industries may also be at risk. This review summarizes the available information on disease characteristics and natural history and provides information on workplace characteristics associated with disease development. Recent findings: Investigations carried out in flavoring plants in California have identified severely affected current and former workers in four plants. Affected former workers have also been identified at a plant in the Netherlands that manufactured diacetyl, a predominant chemical in butter flavorings which has been implicated as a causal agent for lung disease in microwave popcorn workers. Summary: Workers who manufacture or use flavorings can be subjected to repeated intense exposures to flavoring chemicals. Affected workers can progress to severe fixed airways obstruction in as little as 7 months. Since medical treatment is generally ineffective, early identification of affected workers and removal from further exposure, along with control of exposures to protect coworkers, are essential to minimize this hazard.
Keywords	Lung-disease; Airway-obstruction; Occupational-exposure; Occupational-diseases; Airborne-particles; Respiratory-system-disorders; Pulmonary-system-disorders; Worker-health; Exposure-assessment; Exposure-levels; Food-processing-workers; Engineering-controls; Respiratory-protection
Contact	National Institute for Occupational Safety and Health, Division of Respiratory Disease Studies, Mail Stop H-2800, 1095 Willowdale Road, Morgantown, WV 26505
CODEN	COPMFY
CAS No.	431-03-8
Publication Date	20080301
Document Type	Journal Article
Email Address	rkanwal@cdc.gov
Fiscal Year	2008
NTIS Accession No.
NTIS Price
Issue of Publication	2
ISSN	1070-5287
NIOSH Division	DRDS
Source Name	Current Opinion in Pulmonary Medicine
State	WV

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