Bibliographic Citation
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Title | Proliferative kinetics of large and small intraepithelial lymphocytes in the small intestine of the mouse |
Creator/Author | Roepke, C. (Univ. of Washington, Seattle) ; Everett, N.B. |
Publication Date | 1976 Mar 01 |
OSTI Identifier | OSTI ID: 6434170 |
Other Number(s) | CODEN: AJANA |
Resource Type | Journal Article |
Resource Relation | Am. J. Anat. ; Vol/Issue: 145:3 |
Subject | 550300 -- Cytology; ;CELL PROLIFERATION-- KINETICS;LYMPHOCYTES-- CELL PROLIFERATION; AUTORADIOGRAPHY;MICE;SMALL INTESTINE |
Related Subject | ANIMAL CELLS;ANIMALS;BIOLOGICAL MATERIALS;BLOOD;BLOOD CELLS;BODY;BODY FLUIDS;CONNECTIVE TISSUE CELLS;DIGESTIVE SYSTEM;GASTROINTESTINAL TRACT;INTESTINES;LEUKOCYTES;MAMMALS;ORGANS;RODENTS;SOMATIC CELLS;VERTEBRATES |
Description/Abstract | The proliferative kinetics of the intraepithelial lymphocytes (IL) of the mouse intestine have been evaluated.^By inducing mitotic arrest it was found that large IL--constituting about 50% of the IL--showed a mitotic rate of 2.3.^Autoradiographic results obtained after two different schedules of /sup 3/H-thymidine injections showed that 30% of the large IL were in DNA synthesis, and that the large IL were renewed at a rate comparable to that of blast cells from Peyer`s patches, mesenteric lymph nodes and thoracic duct lymph.^The small IL were renewed very rapidly compared to small lymphocytes of peripheral lymphoid tissues, although small lymphocytes with lifespans of several weeks were also present in the epithelial sheet.^By the use of intestinal perfusion, in vivo, it was estimated that the loss of lymphocytes from intestinal villi into the lumen of the gut was negligible, and it is concluded that the most probable kinetic model for the majority of IL is: B and T lymphoblasts invade the epithelium and undergo mitosis.^B lymphoblasts give rise predominantly to plasma cells, and T lymphoblasts give rise to small lymphocytes--probably long-lived--which reenter the circulation. |
Country of Publication | United States |
Language | English |
Format | Pages: 395-408 |
System Entry Date | 2001 May 13 |
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