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HCV Immunology T Helper, CD4+ T-Cell, Search

Found 20 matching records:

Displaying record number 4144

H77 Location Core(31-45) Core Epitope Map
Author Location Core(31-47 genotype 1b)
Epitope VGGVYLLPRRGPRLG Epitope Alignment
Species (MHC/HLA) human
Immunogen HCV infection
Experimental methods Proliferation
Keywords computational epitope prediction, chronic HCV, resolved HCV

Notes

  • This study investigated T-cell proliferative responses to recombinant HCV antigens and 20 synthesized peptides in the well-characterized Irish (Caucasian) cohort infected with HCV in 1977 with contaminated anti-D immunoglobulin. 51 subjects were selected (women), of them one group (25 subjects) with resolved HCV and another group (26 subjects) with persistent infection.
  • The magnitude of response was comparable in two patient groups, but in the viral clearance group HCV-specific T cell responses were more frequently detected and a broader range of peptides were targeted.
  • 11/51 (22%) of the total cohort were positive for the DRB1*0101 allele (7 subjects with viral clearance and 4 subjects with viral persistence), whereas 40/51 (78%) were DRB1*0101 negative. The DRB1*0101 positive group had significantly stronger HCV-specific T-cell responses compared to DRB1*0101 negative group.Also, among individuals with viral clearance, there was a significantly broader HCV-specific T-cell response in DRB1*0101 positive individuals, compared to DRB1*0101 negative individuals.
  • This peptide elicited a significantly greater response in the DRB1*0101 positive group compared to the DRB1*0101 negative group (P=0.001).

References

Barrett2005 Sharon Barrett, Michael Sweeney, and John Crowe. Host immune responses in hepatitis C virus clearance. Eur J Gastroenterol Hepatol, 17(10):1089-97, Oct 2005. PubMed ID: 16148555. Show all entries for this paper.

Displaying record number 4155

H77 Location Core(142-156) Core Epitope Map
Author Location Core(142-159 genotype 1b)
Epitope APLGGAARALAHGVR Epitope Alignment
Species (MHC/HLA) human
Immunogen HCV infection
Experimental methods Proliferation
Keywords computational epitope prediction, chronic HCV, resolved HCV

Notes

  • This study investigated T-cell proliferative responses to recombinant HCV antigens and 20 synthesized peptides in the well-characterized Irish (Caucasian) cohort infected with HCV in 1977 with contaminated anti-D immunoglobulin. 51 subjects were selected (women), of them one group (25 subjects) with resolved HCV and another group (26 subjects) with persistent infection.
  • The magnitude of response was comparable in two patient groups, but in the viral clearance group HCV-specific T cell responses were more frequently detected and a broader range of peptides were targeted.
  • 11/51 (22%) of the total cohort were positive for the DRB1*0101 allele (7 subjects with viral clearance and 4 subjects with viral persistence), whereas 40/51 (78%) were DRB1*0101 negative. The DRB1*0101 positive group had significantly stronger HCV-specific T-cell responses compared to DRB1*0101 negative group.Also, among individuals with viral clearance, there was a significantly broader HCV-specific T-cell response in DRB1*0101 positive individuals, compared to DRB1*0101 negative individuals.

References

Barrett2005 Sharon Barrett, Michael Sweeney, and John Crowe. Host immune responses in hepatitis C virus clearance. Eur J Gastroenterol Hepatol, 17(10):1089-97, Oct 2005. PubMed ID: 16148555. Show all entries for this paper.

Displaying record number 4151

H77 Location Core(173-187) Core Epitope Map
Author Location Core(173-188 genotype 1b)
Epitope SFSIFLLALLSCLTI Epitope Alignment
Species (MHC/HLA) human
Immunogen HCV infection
Experimental methods Proliferation
Keywords computational epitope prediction, chronic HCV, resolved HCV

Notes

  • This study investigated T-cell proliferative responses to recombinant HCV antigens and 20 synthesized peptides in the well-characterized Irish (Caucasian) cohort infected with HCV in 1977 with contaminated anti-D immunoglobulin. 51 subjects were selected (women), of them one group (25 subjects) with resolved HCV and another group (26 subjects) with persistent infection.
  • The magnitude of response was comparable in two patient groups, but in the viral clearance group HCV-specific T cell responses were more frequently detected and a broader range of peptides were targeted.
  • 11/51 (22%) of the total cohort were positive for the DRB1*0101 allele (7 subjects with viral clearance and 4 subjects with viral persistence), whereas 40/51 (78%) were DRB1*0101 negative. The DRB1*0101 positive group had significantly stronger HCV-specific T-cell responses compared to DRB1*0101 negative group.Also, among individuals with viral clearance, there was a significantly broader HCV-specific T-cell response in DRB1*0101 positive individuals, compared to DRB1*0101 negative individuals.
  • This peptide elicited a significantly greater response in the viral clearance group compared to the viral persistence group (P=0.05).

References

Barrett2005 Sharon Barrett, Michael Sweeney, and John Crowe. Host immune responses in hepatitis C virus clearance. Eur J Gastroenterol Hepatol, 17(10):1089-97, Oct 2005. PubMed ID: 16148555. Show all entries for this paper.

Displaying record number 4145

H77 Location E1(236-250) E1 Epitope Map
Author Location E1(236-251 genotype 1b)
Epitope SRCWVALTPTLAARN Epitope Alignment
Species (MHC/HLA) human
Immunogen HCV infection
Experimental methods Proliferation
Keywords computational epitope prediction, chronic HCV, resolved HCV

Notes

  • This study investigated T-cell proliferative responses to recombinant HCV antigens and 20 synthesized peptides in the well-characterized Irish (Caucasian) cohort infected with HCV in 1977 with contaminated anti-D immunoglobulin. 51 subjects were selected (women), of them one group (25 subjects) with resolved HCV and another group (26 subjects) with persistent infection.
  • The magnitude of response was comparable in two patient groups, but in the viral clearance group HCV-specific T cell responses were more frequently detected and a broader range of peptides were targeted.
  • 11/51 (22%) of the total cohort were positive for the DRB1*0101 allele (7 subjects with viral clearance and 4 subjects with viral persistence), whereas 40/51 (78%) were DRB1*0101 negative. The DRB1*0101 positive group had significantly stronger HCV-specific T-cell responses compared to DRB1*0101 negative group.Also, among individuals with viral clearance, there was a significantly broader HCV-specific T-cell response in DRB1*0101 positive individuals, compared to DRB1*0101 negative individuals.
  • This peptide elicited a significantly greater response in the DRB1*0101 positive group compared to the DRB1*0101 negative group (P=0.027).

References

Barrett2005 Sharon Barrett, Michael Sweeney, and John Crowe. Host immune responses in hepatitis C virus clearance. Eur J Gastroenterol Hepatol, 17(10):1089-97, Oct 2005. PubMed ID: 16148555. Show all entries for this paper.

Displaying record number 4146

H77 Location E2(734-749) E2 Epitope Map
Author Location NS2(736-752 genotype 1b)
Epitope CLWMMLLIAQAEQALL Epitope Alignment
Species (MHC/HLA) human
Immunogen HCV infection
Experimental methods Proliferation
Keywords computational epitope prediction, chronic HCV, resolved HCV

Notes

  • This study investigated T-cell proliferative responses to recombinant HCV antigens and 20 synthesized peptides in the well-characterized Irish (Caucasian) cohort infected with HCV in 1977 with contaminated anti-D immunoglobulin. 51 subjects were selected (women), of them one group (25 subjects) with resolved HCV and another group (26 subjects) with persistent infection.
  • The magnitude of response was comparable in two patient groups, but in the viral clearance group HCV-specific T cell responses were more frequently detected and a broader range of peptides were targeted.
  • 11/51 (22%) of the total cohort were positive for the DRB1*0101 allele (7 subjects with viral clearance and 4 subjects with viral persistence), whereas 40/51 (78%) were DRB1*0101 negative. The DRB1*0101 positive group had significantly stronger HCV-specific T-cell responses compared to DRB1*0101 negative group.Also, among individuals with viral clearance, there was a significantly broader HCV-specific T-cell response in DRB1*0101 positive individuals, compared to DRB1*0101 negative individuals.
  • This peptide elicited a significantly greater response in the DRB1*0101 positive group compared to the DRB1*0101 negative group (P=0.006).

References

Barrett2005 Sharon Barrett, Michael Sweeney, and John Crowe. Host immune responses in hepatitis C virus clearance. Eur J Gastroenterol Hepatol, 17(10):1089-97, Oct 2005. PubMed ID: 16148555. Show all entries for this paper.

Displaying record number 4156

H77 Location NS2(809-823) NS2 Epitope Map
Author Location NS2(811-826 genotype 1b)
Epitope AMDREMAASCGGAVF Epitope Alignment
Species (MHC/HLA) human
Immunogen HCV infection
Experimental methods Proliferation
Keywords computational epitope prediction, chronic HCV, resolved HCV

Notes

  • This study investigated T-cell proliferative responses to recombinant HCV antigens and 20 synthesized peptides in the well-characterized Irish (Caucasian) cohort infected with HCV in 1977 with contaminated anti-D immunoglobulin. 51 subjects were selected (women), of them one group (25 subjects) with resolved HCV and another group (26 subjects) with persistent infection.
  • The magnitude of response was comparable in two patient groups, but in the viral clearance group HCV-specific T cell responses were more frequently detected and a broader range of peptides were targeted.
  • 11/51 (22%) of the total cohort were positive for the DRB1*0101 allele (7 subjects with viral clearance and 4 subjects with viral persistence), whereas 40/51 (78%) were DRB1*0101 negative. The DRB1*0101 positive group had significantly stronger HCV-specific T-cell responses compared to DRB1*0101 negative group.Also, among individuals with viral clearance, there was a significantly broader HCV-specific T-cell response in DRB1*0101 positive individuals, compared to DRB1*0101 negative individuals.

References

Barrett2005 Sharon Barrett, Michael Sweeney, and John Crowe. Host immune responses in hepatitis C virus clearance. Eur J Gastroenterol Hepatol, 17(10):1089-97, Oct 2005. PubMed ID: 16148555. Show all entries for this paper.

Displaying record number 4157

H77 Location NS2(870-884) NS2 Epitope Map
Author Location NS2(872-887 genotype 1b)
Epitope RDAIILLTCAVHPEL Epitope Alignment
Species (MHC/HLA) human
Immunogen HCV infection
Experimental methods Proliferation
Keywords computational epitope prediction, chronic HCV, resolved HCV

Notes

  • This study investigated T-cell proliferative responses to recombinant HCV antigens and 20 synthesized peptides in the well-characterized Irish (Caucasian) cohort infected with HCV in 1977 with contaminated anti-D immunoglobulin. 51 subjects were selected (women), of them one group (25 subjects) with resolved HCV and another group (26 subjects) with persistent infection.
  • The magnitude of response was comparable in two patient groups, but in the viral clearance group HCV-specific T cell responses were more frequently detected and a broader range of peptides were targeted.
  • 11/51 (22%) of the total cohort were positive for the DRB1*0101 allele (7 subjects with viral clearance and 4 subjects with viral persistence), whereas 40/51 (78%) were DRB1*0101 negative. The DRB1*0101 positive group had significantly stronger HCV-specific T-cell responses compared to DRB1*0101 negative group.Also, among individuals with viral clearance, there was a significantly broader HCV-specific T-cell response in DRB1*0101 positive individuals, compared to DRB1*0101 negative individuals.

References

Barrett2005 Sharon Barrett, Michael Sweeney, and John Crowe. Host immune responses in hepatitis C virus clearance. Eur J Gastroenterol Hepatol, 17(10):1089-97, Oct 2005. PubMed ID: 16148555. Show all entries for this paper.

Displaying record number 4158

H77 Location NS2(897-911) NS2 Epitope Map
Author Location NS2(898-913 genotype 1b)
Epitope GPLMVLQAGIIRAPY Epitope Alignment
Species (MHC/HLA) human
Immunogen HCV infection
Experimental methods Proliferation
Keywords computational epitope prediction, chronic HCV, resolved HCV

Notes

  • This study investigated T-cell proliferative responses to recombinant HCV antigens and 20 synthesized peptides in the well-characterized Irish (Caucasian) cohort infected with HCV in 1977 with contaminated anti-D immunoglobulin. 51 subjects were selected (women), of them one group (25 subjects) with resolved HCV and another group (26 subjects) with persistent infection.
  • The magnitude of response was comparable in two patient groups, but in the viral clearance group HCV-specific T cell responses were more frequently detected and a broader range of peptides were targeted.
  • 11/51 (22%) of the total cohort were positive for the DRB1*0101 allele (7 subjects with viral clearance and 4 subjects with viral persistence), whereas 40/51 (78%) were DRB1*0101 negative. The DRB1*0101 positive group had significantly stronger HCV-specific T-cell responses compared to DRB1*0101 negative group.Also, among individuals with viral clearance, there was a significantly broader HCV-specific T-cell response in DRB1*0101 positive individuals, compared to DRB1*0101 negative individuals.

References

Barrett2005 Sharon Barrett, Michael Sweeney, and John Crowe. Host immune responses in hepatitis C virus clearance. Eur J Gastroenterol Hepatol, 17(10):1089-97, Oct 2005. PubMed ID: 16148555. Show all entries for this paper.

Displaying record number 4147

H77 Location NS3(1020-1034) NS3 Epitope Map
Author Location NS3(1022-1037 genotype 1b)
Epitope GQGWRLLAPITAYSQ Epitope Alignment
Species (MHC/HLA) human
Immunogen HCV infection
Experimental methods Proliferation
Keywords computational epitope prediction, chronic HCV, resolved HCV

Notes

  • This study investigated T-cell proliferative responses to recombinant HCV antigens and 20 synthesized peptides in the well-characterized Irish (Caucasian) cohort infected with HCV in 1977 with contaminated anti-D immunoglobulin. 51 subjects were selected (women), of them one group (25 subjects) with resolved HCV and another group (26 subjects) with persistent infection.
  • The magnitude of response was comparable in two patient groups, but in the viral clearance group HCV-specific T cell responses were more frequently detected and a broader range of peptides were targeted.
  • 11/51 (22%) of the total cohort were positive for the DRB1*0101 allele (7 subjects with viral clearance and 4 subjects with viral persistence), whereas 40/51 (78%) were DRB1*0101 negative. The DRB1*0101 positive group had significantly stronger HCV-specific T-cell responses compared to DRB1*0101 negative group.Also, among individuals with viral clearance, there was a significantly broader HCV-specific T-cell response in DRB1*0101 positive individuals, compared to DRB1*0101 negative individuals.
  • This peptide elicited a significantly greater response in the DRB1*0101 positive group compared to the DRB1*0101 negative group (P=0.008).

References

Barrett2005 Sharon Barrett, Michael Sweeney, and John Crowe. Host immune responses in hepatitis C virus clearance. Eur J Gastroenterol Hepatol, 17(10):1089-97, Oct 2005. PubMed ID: 16148555. Show all entries for this paper.

Displaying record number 4159

H77 Location NS3(1246-1260) NS3 Epitope Map
Author Location NS3(1248-1263 genotype 1b)
Epitope AQGYKVLVLNPSVAA Epitope Alignment
Species (MHC/HLA) human
Immunogen HCV infection
Experimental methods Proliferation
Keywords computational epitope prediction, chronic HCV, resolved HCV

Notes

  • This study investigated T-cell proliferative responses to recombinant HCV antigens and 20 synthesized peptides in the well-characterized Irish (Caucasian) cohort infected with HCV in 1977 with contaminated anti-D immunoglobulin. 51 subjects were selected (women), of them one group (25 subjects) with resolved HCV and another group (26 subjects) with persistent infection.
  • The magnitude of response was comparable in two patient groups, but in the viral clearance group HCV-specific T cell responses were more frequently detected and a broader range of peptides were targeted.
  • 11/51 (22%) of the total cohort were positive for the DRB1*0101 allele (7 subjects with viral clearance and 4 subjects with viral persistence), whereas 40/51 (78%) were DRB1*0101 negative. The DRB1*0101 positive group had significantly stronger HCV-specific T-cell responses compared to DRB1*0101 negative group.Also, among individuals with viral clearance, there was a significantly broader HCV-specific T-cell response in DRB1*0101 positive individuals, compared to DRB1*0101 negative individuals.

References

Barrett2005 Sharon Barrett, Michael Sweeney, and John Crowe. Host immune responses in hepatitis C virus clearance. Eur J Gastroenterol Hepatol, 17(10):1089-97, Oct 2005. PubMed ID: 16148555. Show all entries for this paper.

Displaying record number 4152

H77 Location NS3(1559-1573) NS3 Epitope Map
Author Location NS3(1561-1576 genotype 1b)
Epitope ESVFTGLTHIDAHFL Epitope Alignment
Species (MHC/HLA) human
Immunogen HCV infection
Experimental methods Proliferation
Keywords computational epitope prediction, chronic HCV, resolved HCV

Notes

  • This study investigated T-cell proliferative responses to recombinant HCV antigens and 20 synthesized peptides in the well-characterized Irish (Caucasian) cohort infected with HCV in 1977 with contaminated anti-D immunoglobulin. 51 subjects were selected (women), of them one group (25 subjects) with resolved HCV and another group (26 subjects) with persistent infection.
  • The magnitude of response was comparable in two patient groups, but in the viral clearance group HCV-specific T cell responses were more frequently detected and a broader range of peptides were targeted.
  • 11/51 (22%) of the total cohort were positive for the DRB1*0101 allele (7 subjects with viral clearance and 4 subjects with viral persistence), whereas 40/51 (78%) were DRB1*0101 negative. The DRB1*0101 positive group had significantly stronger HCV-specific T-cell responses compared to DRB1*0101 negative group.Also, among individuals with viral clearance, there was a significantly broader HCV-specific T-cell response in DRB1*0101 positive individuals, compared to DRB1*0101 negative individuals.
  • This peptide elicited a significantly greater response in the viral clearance group compared to the viral persistence group (P=0.015).

References

Barrett2005 Sharon Barrett, Michael Sweeney, and John Crowe. Host immune responses in hepatitis C virus clearance. Eur J Gastroenterol Hepatol, 17(10):1089-97, Oct 2005. PubMed ID: 16148555. Show all entries for this paper.

Displaying record number 4148

H77 Location NS3(1605-1619) NS3 Epitope Map
Author Location NS3(1607-1623 genotype 1b)
Epitope DQMWLKCLIRLKPTLH Epitope Alignment
Species (MHC/HLA) human
Immunogen HCV infection
Experimental methods Proliferation
Keywords computational epitope prediction, chronic HCV, resolved HCV

Notes

  • This study investigated T-cell proliferative responses to recombinant HCV antigens and 20 synthesized peptides in the well-characterized Irish (Caucasian) cohort infected with HCV in 1977 with contaminated anti-D immunoglobulin. 51 subjects were selected (women), of them one group (25 subjects) with resolved HCV and another group (26 subjects) with persistent infection.
  • The magnitude of response was comparable in two patient groups, but in the viral clearance group HCV-specific T cell responses were more frequently detected and a broader range of peptides were targeted.
  • 11/51 (22%) of the total cohort were positive for the DRB1*0101 allele (7 subjects with viral clearance and 4 subjects with viral persistence), whereas 40/51 (78%) were DRB1*0101 negative. The DRB1*0101 positive group had significantly stronger HCV-specific T-cell responses compared to DRB1*0101 negative group.Also, among individuals with viral clearance, there was a significantly broader HCV-specific T-cell response in DRB1*0101 positive individuals, compared to DRB1*0101 negative individuals.
  • This peptide elicited a significantly greater response in the DRB1*0101 positive group compared to the DRB1*0101 negative group (P=0.031).

References

Barrett2005 Sharon Barrett, Michael Sweeney, and John Crowe. Host immune responses in hepatitis C virus clearance. Eur J Gastroenterol Hepatol, 17(10):1089-97, Oct 2005. PubMed ID: 16148555. Show all entries for this paper.

Displaying record number 4160

H77 Location NS3(1640-1655) NS3 Epitope Map
Author Location NS3(1642-1657 genotype 1b)
Epitope PVTKYIMACSADLES Epitope Alignment
Species (MHC/HLA) human
Immunogen HCV infection
Experimental methods Proliferation
Keywords computational epitope prediction, chronic HCV, resolved HCV

Notes

  • This study investigated T-cell proliferative responses to recombinant HCV antigens and 20 synthesized peptides in the well-characterized Irish (Caucasian) cohort infected with HCV in 1977 with contaminated anti-D immunoglobulin. 51 subjects were selected (women), of them one group (25 subjects) with resolved HCV and another group (26 subjects) with persistent infection.
  • The magnitude of response was comparable in two patient groups, but in the viral clearance group HCV-specific T cell responses were more frequently detected and a broader range of peptides were targeted.
  • 11/51 (22%) of the total cohort were positive for the DRB1*0101 allele (7 subjects with viral clearance and 4 subjects with viral persistence), whereas 40/51 (78%) were DRB1*0101 negative. The DRB1*0101 positive group had significantly stronger HCV-specific T-cell responses compared to DRB1*0101 negative group.Also, among individuals with viral clearance, there was a significantly broader HCV-specific T-cell response in DRB1*0101 positive individuals, compared to DRB1*0101 negative individuals.

References

Barrett2005 Sharon Barrett, Michael Sweeney, and John Crowe. Host immune responses in hepatitis C virus clearance. Eur J Gastroenterol Hepatol, 17(10):1089-97, Oct 2005. PubMed ID: 16148555. Show all entries for this paper.

Displaying record number 4161

H77 Location NS3(1657-1671) NS3 Epitope Map
Author Location NS3(1658-1674 genotype 1b)
Epitope TSTWVLVGGVLAALA Epitope Alignment
Species (MHC/HLA) human
Immunogen HCV infection
Experimental methods Proliferation
Keywords computational epitope prediction, chronic HCV, resolved HCV

Notes

  • This study investigated T-cell proliferative responses to recombinant HCV antigens and 20 synthesized peptides in the well-characterized Irish (Caucasian) cohort infected with HCV in 1977 with contaminated anti-D immunoglobulin. 51 subjects were selected (women), of them one group (25 subjects) with resolved HCV and another group (26 subjects) with persistent infection.
  • The magnitude of response was comparable in two patient groups, but in the viral clearance group HCV-specific T cell responses were more frequently detected and a broader range of peptides were targeted.
  • 11/51 (22%) of the total cohort were positive for the DRB1*0101 allele (7 subjects with viral clearance and 4 subjects with viral persistence), whereas 40/51 (78%) were DRB1*0101 negative. The DRB1*0101 positive group had significantly stronger HCV-specific T-cell responses compared to DRB1*0101 negative group.Also, among individuals with viral clearance, there was a significantly broader HCV-specific T-cell response in DRB1*0101 positive individuals, compared to DRB1*0101 negative individuals.

References

Barrett2005 Sharon Barrett, Michael Sweeney, and John Crowe. Host immune responses in hepatitis C virus clearance. Eur J Gastroenterol Hepatol, 17(10):1089-97, Oct 2005. PubMed ID: 16148555. Show all entries for this paper.

Displaying record number 4153

H77 Location NS4b(1803-1817) NS4b Epitope Map
Author Location NS4b(1808-1823 genotype 1b)
Epitope TQHTLLFNILGGWVA Epitope Alignment
Species (MHC/HLA) human
Immunogen HCV infection
Experimental methods Proliferation
Keywords computational epitope prediction, chronic HCV, resolved HCV

Notes

  • This study investigated T-cell proliferative responses to recombinant HCV antigens and 20 synthesized peptides in the well-characterized Irish (Caucasian) cohort infected with HCV in 1977 with contaminated anti-D immunoglobulin. 51 subjects were selected (women), of them one group (25 subjects) with resolved HCV and another group (26 subjects) with persistent infection.
  • The magnitude of response was comparable in two patient groups, but in the viral clearance group HCV-specific T cell responses were more frequently detected and a broader range of peptides were targeted.
  • 11/51 (22%) of the total cohort were positive for the DRB1*0101 allele (7 subjects with viral clearance and 4 subjects with viral persistence), whereas 40/51 (78%) were DRB1*0101 negative. The DRB1*0101 positive group had significantly stronger HCV-specific T-cell responses compared to DRB1*0101 negative group.Also, among individuals with viral clearance, there was a significantly broader HCV-specific T-cell response in DRB1*0101 positive individuals, compared to DRB1*0101 negative individuals.
  • This peptide elicited a significantly greater response in the viral clearance group compared to the viral persistence group (P=0.05).

References

Barrett2005 Sharon Barrett, Michael Sweeney, and John Crowe. Host immune responses in hepatitis C virus clearance. Eur J Gastroenterol Hepatol, 17(10):1089-97, Oct 2005. PubMed ID: 16148555. Show all entries for this paper.

Displaying record number 4162

H77 Location NS4b(1844-1858) NS4b Epitope Map
Author Location NS4b(1846-1861 genotype 1b)
Epitope LGKVLVDILAGYGAG Epitope Alignment
Species (MHC/HLA) human
Immunogen HCV infection
Experimental methods Proliferation
Keywords computational epitope prediction, chronic HCV, resolved HCV

Notes

  • This study investigated T-cell proliferative responses to recombinant HCV antigens and 20 synthesized peptides in the well-characterized Irish (Caucasian) cohort infected with HCV in 1977 with contaminated anti-D immunoglobulin. 51 subjects were selected (women), of them one group (25 subjects) with resolved HCV and another group (26 subjects) with persistent infection.
  • The magnitude of response was comparable in two patient groups, but in the viral clearance group HCV-specific T cell responses were more frequently detected and a broader range of peptides were targeted.
  • 11/51 (22%) of the total cohort were positive for the DRB1*0101 allele (7 subjects with viral clearance and 4 subjects with viral persistence), whereas 40/51 (78%) were DRB1*0101 negative. The DRB1*0101 positive group had significantly stronger HCV-specific T-cell responses compared to DRB1*0101 negative group.Also, among individuals with viral clearance, there was a significantly broader HCV-specific T-cell response in DRB1*0101 positive individuals, compared to DRB1*0101 negative individuals.

References

Barrett2005 Sharon Barrett, Michael Sweeney, and John Crowe. Host immune responses in hepatitis C virus clearance. Eur J Gastroenterol Hepatol, 17(10):1089-97, Oct 2005. PubMed ID: 16148555. Show all entries for this paper.

Displaying record number 4149

H77 Location NS4b(1910-1924) NS4b Epitope Map
Author Location NS4b(1910-1925 genotype 1b)
Epitope EGAVQWMNRLIAFAS Epitope Alignment
Species (MHC/HLA) human
Immunogen HCV infection
Experimental methods Proliferation
Keywords computational epitope prediction, chronic HCV, resolved HCV

Notes

  • This study investigated T-cell proliferative responses to recombinant HCV antigens and 20 synthesized peptides in the well-characterized Irish (Caucasian) cohort infected with HCV in 1977 with contaminated anti-D immunoglobulin. 51 subjects were selected (women), of them one group (25 subjects) with resolved HCV and another group (26 subjects) with persistent infection.
  • The magnitude of response was comparable in two patient groups, but in the viral clearance group HCV-specific T cell responses were more frequently detected and a broader range of peptides were targeted.
  • 11/51 (22%) of the total cohort were positive for the DRB1*0101 allele (7 subjects with viral clearance and 4 subjects with viral persistence), whereas 40/51 (78%) were DRB1*0101 negative. The DRB1*0101 positive group had significantly stronger HCV-specific T-cell responses compared to DRB1*0101 negative group.Also, among individuals with viral clearance, there was a significantly broader HCV-specific T-cell response in DRB1*0101 positive individuals, compared to DRB1*0101 negative individuals.
  • This peptide elicited a significantly greater response in the DRB1*0101 positive group compared to the DRB1*0101 negative group (P=0.015).

References

Barrett2005 Sharon Barrett, Michael Sweeney, and John Crowe. Host immune responses in hepatitis C virus clearance. Eur J Gastroenterol Hepatol, 17(10):1089-97, Oct 2005. PubMed ID: 16148555. Show all entries for this paper.

Displaying record number 4150

H77 Location NS5a(2227-2241) NS5a Epitope Map
Author Location NS5a(2229-2244 genotype 1b)
Epitope IEANLLWRQEMGGNI Epitope Alignment
Species (MHC/HLA) human
Immunogen HCV infection
Experimental methods Proliferation
Keywords computational epitope prediction, chronic HCV, resolved HCV

Notes

  • This study investigated T-cell proliferative responses to recombinant HCV antigens and 20 synthesized peptides in the well-characterized Irish (Caucasian) cohort infected with HCV in 1977 with contaminated anti-D immunoglobulin. 51 subjects were selected (women), of them one group (25 subjects) with resolved HCV and another group (26 subjects) with persistent infection.
  • The magnitude of response was comparable in two patient groups, but in the viral clearance group HCV-specific T cell responses were more frequently detected and a broader range of peptides were targeted.
  • 11/51 (22%) of the total cohort were positive for the DRB1*0101 allele (7 subjects with viral clearance and 4 subjects with viral persistence), whereas 40/51 (78%) were DRB1*0101 negative. The DRB1*0101 positive group had significantly stronger HCV-specific T-cell responses compared to DRB1*0101 negative group.Also, among individuals with viral clearance, there was a significantly broader HCV-specific T-cell response in DRB1*0101 positive individuals, compared to DRB1*0101 negative individuals.
  • This peptide elicited a significantly greater response in the DRB1*0101 positive group compared to the DRB1*0101 negative group (P=0.031).
  • This peptide elicited a significantly greater response in the viral clearance group compared to the viral persistence group (P=0.006).

References

Barrett2005 Sharon Barrett, Michael Sweeney, and John Crowe. Host immune responses in hepatitis C virus clearance. Eur J Gastroenterol Hepatol, 17(10):1089-97, Oct 2005. PubMed ID: 16148555. Show all entries for this paper.

Displaying record number 4154

H77 Location NS5b(2695-2706) NS5b Epitope Map
Author Location NS5b(2693-2708 genotype 1b)
Epitope GYRRCRASGVLT Epitope Alignment
Species (MHC/HLA) human
Immunogen HCV infection
Experimental methods Proliferation
Keywords computational epitope prediction, chronic HCV, resolved HCV

Notes

  • This study investigated T-cell proliferative responses to recombinant HCV antigens and 20 synthesized peptides in the well-characterized Irish (Caucasian) cohort infected with HCV in 1977 with contaminated anti-D immunoglobulin. 51 subjects were selected (women), of them one group (25 subjects) with resolved HCV and another group (26 subjects) with persistent infection.
  • The magnitude of response was comparable in two patient groups, but in the viral clearance group HCV-specific T cell responses were more frequently detected and a broader range of peptides were targeted.
  • 11/51 (22%) of the total cohort were positive for the DRB1*0101 allele (7 subjects with viral clearance and 4 subjects with viral persistence), whereas 40/51 (78%) were DRB1*0101 negative. The DRB1*0101 positive group had significantly stronger HCV-specific T-cell responses compared to DRB1*0101 negative group.Also, among individuals with viral clearance, there was a significantly broader HCV-specific T-cell response in DRB1*0101 positive individuals, compared to DRB1*0101 negative individuals.
  • This peptide elicited a significantly greater response in the viral clearance group compared to the viral persistence group (P=0.031).

References

Barrett2005 Sharon Barrett, Michael Sweeney, and John Crowe. Host immune responses in hepatitis C virus clearance. Eur J Gastroenterol Hepatol, 17(10):1089-97, Oct 2005. PubMed ID: 16148555. Show all entries for this paper.

Displaying record number 4163

H77 Location NS5b(2845-2860) NS5b Epitope Map
Author Location NS5b(2846-2861 genotype 1b)
Epitope LMIHFFSILAQEQLE Epitope Alignment
Species (MHC/HLA) human
Immunogen HCV infection
Experimental methods Proliferation
Keywords computational epitope prediction, chronic HCV, resolved HCV

Notes

  • This study investigated T-cell proliferative responses to recombinant HCV antigens and 20 synthesized peptides in the well-characterized Irish (Caucasian) cohort infected with HCV in 1977 with contaminated anti-D immunoglobulin. 51 subjects were selected (women), of them one group (25 subjects) with resolved HCV and another group (26 subjects) with persistent infection.
  • The magnitude of response was comparable in two patient groups, but in the viral clearance group HCV-specific T cell responses were more frequently detected and a broader range of peptides were targeted.
  • 11/51 (22%) of the total cohort were positive for the DRB1*0101 allele (7 subjects with viral clearance and 4 subjects with viral persistence), whereas 40/51 (78%) were DRB1*0101 negative. The DRB1*0101 positive group had significantly stronger HCV-specific T-cell responses compared to DRB1*0101 negative group.Also, among individuals with viral clearance, there was a significantly broader HCV-specific T-cell response in DRB1*0101 positive individuals, compared to DRB1*0101 negative individuals.

References

Barrett2005 Sharon Barrett, Michael Sweeney, and John Crowe. Host immune responses in hepatitis C virus clearance. Eur J Gastroenterol Hepatol, 17(10):1089-97, Oct 2005. PubMed ID: 16148555. Show all entries for this paper.

 
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