N-acetylcysteine suppression of the proliferative index in the colon of patients with previous adenomatous colonic polyps.

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Title:	N-acetylcysteine suppression of the proliferative index in the colon of patients with previous adenomatous colonic polyps.
Author:	Estensen, R D : Levy, M : Klopp, S J : Galbraith, A R : Mandel, J S : Blomquist, J A : Wattenberg, L W
Citation:	Cancer-Lett. 1999 Dec 1; 147(1-2): 109-14
Abstract:	This investigation is part of an effort to develop chemoprevention for carcinogenesis of the large bowel. The agent investigated is N-acetylcysteine (NAC). We used as a predictive biomarker, the proliferative index (PI), in a short-term human study. Patients with previous adenomatous colonic polyps are a cohort with increased risk for colon cancer and an increased PI of colonic crypts. They were randomly assigned to an experimental group given 800 mg/day of NAC for 12 weeks or a placebo group. Using proliferative cell nuclear antigen immunostaining, the PI of colonic crypts was measured prior to and after the treatments. The PI of the NAC group was decreased significantly (P less than 0.02) while the placebo group showed no difference (P greater than 0.45). Since this decrease in PI may be an indicator of decreased risk of colon cancer, more extensive studies of the potential of NAC as a chemopreventive agent for colon cancer appear warranted.
Review References:	None
Notes:	None
Language:	English
Publication Type:	Clinical-Trial; Journal-Article; Randomized-Controlled-Trial
Keywords:	Acetylcysteine administration and dosage : Adenomatous Polyps prevention and control : Colonic Polyps prevention and control : Colorectal Neoplasms prevention and control : Free Radical Scavengers administration and dosage : Mitotic Index drug effects
URL:	http://www.elsevier.com/locate/canlet