Gambaro P, Mauri M, Fusi L, Bertora P, Cargnel A, Mangoni A.

J Neurovirol. 1998 Jun 3-6; 4: 350.

Universita degli Studi di Milano, Italy.

BACKGROUND: Asymptomatic central nervous system (CNS) involvement is often described in early stages of HIV infection. In order to verify early CNS dysfunction and to evaluate its significance in disease evolution, we performed a neurophysiological longitudinal study. METHODS: We submitted 30 neurologically asymptomatic HIV+ subjects, without AIDS, to auditory (BAEPs), visual (VEPS), somatosensory (SSEPs) evoked potentials and event related potentials (ERPs). Patients were tested at 6-month intervals for up to 36 months. Each follow-up was compared to baseline and to a control group of 20 healthy age-matched subjects. RESULTS AND CONCLUSIONS: Median nerve SSEPs showed a reduction of N20 amplitude at every follow-up vs. baseline (p<0.05); tibial nerve SSEPs showed a prolongation of N21 and P40 latencies (p<0.05) associated with an increased central conduction time at every follow-up vs. baseline (p<0.03), VEPs showed a prolongation of size 15' and 30' P100 latency, at every follow-up vs. baseline (p<0.04) and at 6-12-18 month follow-up vs. controls (p<0.05); P100 amplitude was not significantly reduced. BAEPs showed no alterations at all controls. Analysis of ERPs showed a reduction of mean P300 amplitude and an increase of mean P300 latency in HIV subjects vs. controls at every follow-up, not reaching a statistical significance. EP changes were correlated to indexes of disease progression such as CD4+ cell count and beta2-microglobulin value.

Publication Types:

• Meeting Abstracts

Keywords:

• Acquired Immunodeficiency Syndrome
• CD4 Lymphocyte Count
• Case-Control Studies
• Central Nervous System
• Evoked Potentials
• HIV Infections
• HIV Seropositivity
• Humans
• Longitudinal Studies
• Median Nerve
• Neurosciences

Other ID:

• 99930712

UI: 102237406

From Meeting Abstracts