NTP Experiment-Test: 55312-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 07/05/00 Route: SKIN APPLICATION Time: 15:00:52 FINAL#2/MICE Facility: Battelle Columbus Laboratory Chemical CAS #: 68603-42-9 Lock Date: 09/06/95 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All a Number of animals examined microscopically at site and number of animals with lesion Page 1 NTP Experiment-Test: 55312-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 07/05/00 Route: SKIN APPLICATION Time: 15:00:52 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE 0 MG/KG 100 200 MG/KG MG/KG ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially in Study 50 50 50 Early Deaths Moribund Sacrifice 11 11 15 Natural Death 4 3 9 Survivors Terminal Sacrifice 35 35 26 Natural Death 1 Animals Examined Microscopically 50 50 50 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Gallbladder (49) (48) (50) Intestine Large, Rectum (50) (50) (50) Intestine Small, Duodenum (50) (50) (50) Leiomyosarcoma, Metastatic, Intestine Small, Jejunum 1 (2%) Polyp Adenomatous 1 (2%) Intestine Small, Jejunum (49) (50) (50) Carcinoma 1 (2%) Leiomyosarcoma 1 (2%) Liver (50) (50) (50) Carcinoma, Metastatic, Harderian Gland 1 (2%) Carcinoma, Metastatic, Thyroid Gland 1 (2%) Hemangiosarcoma, Multiple 1 (2%) Hepatoblastoma 1 (2%) 2 (4%) Hepatoblastoma, Multiple 1 (2%) Hepatocellular Carcinoma 1 (2%) 17 (34%) 16 (32%) Hepatocellular Carcinoma, Multiple 2 (4%) 4 (8%) 16 (32%) Hepatocellular Adenoma 8 (16%) 5 (10%) 5 (10%) Hepatocellular Adenoma, Multiple 24 (48%) 39 (78%) 38 (76%) Histiocytic Sarcoma 1 (2%) 1 (2%) 1 (2%) Leiomyosarcoma, Metastatic, Intestine Small, Jejunum 1 (2%) Mesentery (12) (9) (8) Leiomyosarcoma, Metastatic, Intestine Small, Jejunum 1 (11%) Pancreas (50) (50) (50) Hemangioma 1 (2%) Leiomyosarcoma, Metastatic, Intestine Small, Page 2 NTP Experiment-Test: 55312-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 07/05/00 Route: SKIN APPLICATION Time: 15:00:52 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE 0 MG/KG 100 200 MG/KG MG/KG ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont Jejunum 1 (2%) Salivary Glands (50) (50) (50) Stomach, Forestomach (50) (50) (50) Squamous Cell Papilloma 1 (2%) 2 (4%) 1 (2%) Stomach, Glandular (50) (50) (50) Tongue (1) Squamous Cell Carcinoma 1 (100%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Heart (50) (50) (50) Carcinoma, Metastatic, Thyroid Gland 1 (2%) ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (50) (50) (50) Adenoma 1 (2%) Adrenal Medulla (50) (50) (50) Pheochromocytoma Malignant 1 (2%) Pheochromocytoma Complex 1 (2%) Pheochromocytoma Benign 2 (4%) 1 (2%) Islets, Pancreatic (50) (50) (50) Adenoma 1 (2%) 1 (2%) Pituitary Gland (48) (50) (49) Pars Distalis, Adenoma 5 (10%) 2 (4%) 1 (2%) Pars Distalis, Carcinoma 1 (2%) 1 (2%) Pars Intermedia, Adenoma 1 (2%) 1 (2%) Thyroid Gland (50) (50) (50) C-Cell, Carcinoma 1 (2%) Follicular Cell, Adenoma 2 (4%) 5 (10%) 3 (6%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ Page 3 NTP Experiment-Test: 55312-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 07/05/00 Route: SKIN APPLICATION Time: 15:00:52 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE 0 MG/KG 100 200 MG/KG MG/KG ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Clitoral Gland (48) (49) (47) Carcinoma 1 (2%) Histiocytic Sarcoma 1 (2%) Ovary (50) (50) (50) Cystadenoma 3 (6%) 1 (2%) Granulosa Cell Tumor Malignant 1 (2%) Hemangioma 1 (2%) Hemangiosarcoma 1 (2%) Histiocytic Sarcoma 1 (2%) Luteoma 1 (2%) Teratoma Benign 1 (2%) Teratoma Malignant 1 (2%) Uterus (50) (50) (50) Hemangioma 1 (2%) Histiocytic Sarcoma 1 (2%) Leiomyosarcoma 1 (2%) Polyp Stromal 1 (2%) 2 (4%) 2 (4%) Vagina (1) Histiocytic Sarcoma 1 (100%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Bone Marrow (50) (50) (50) Hemangiosarcoma 1 (2%) Hemangiosarcoma, Metastatic, Ovary 1 (2%) Histiocytic Sarcoma 1 (2%) Lymph Node (7) (3) (6) Bronchial, Histiocytic Sarcoma 1 (33%) Inguinal, Fibrosarcoma, Metastatic, Skin 1 (14%) Lumbar, Histiocytic Sarcoma 1 (17%) Mediastinal, Alveolar/Bronchiolar Carcinoma, Metastatic, Lung 1 (17%) Mediastinal, Carcinoma, Metastatic, Thyroid Gland 1 (14%) Mediastinal, Hepatoblastoma, Metastatic, Liver 1 (33%) Mediastinal, Histiocytic Sarcoma 1 (33%) 1 (17%) Pancreatic, Carcinoma, Metastatic, Thyroid Gland 1 (14%) Lymph Node, Mandibular (49) (47) (49) Carcinoma, Metastatic, Thyroid Gland 1 (2%) Page 4 NTP Experiment-Test: 55312-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 07/05/00 Route: SKIN APPLICATION Time: 15:00:52 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE 0 MG/KG 100 200 MG/KG MG/KG ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont Histiocytic Sarcoma 1 (2%) Lymph Node, Mesenteric (48) (50) (49) Histiocytic Sarcoma 1 (2%) 1 (2%) Leiomyosarcoma, Metastatic, Intestine Small, Jejunum 1 (2%) Spleen (50) (50) (50) Histiocytic Sarcoma 1 (2%) Leiomyosarcoma, Metastatic, Intestine Small, Jejunum 1 (2%) Thymus (47) (40) (41) Leiomyosarcoma, Metastatic, Intestine Small, Jejunum 1 (3%) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Mammary Gland (48) (49) (50) Carcinoma 1 (2%) 1 (2%) Skin (50) (50) (50) Melanoma Benign 1 (2%) Melanoma Malignant 1 (2%) Subcutaneous Tissue, Fibrosarcoma 1 (2%) 1 (2%) Subcutaneous Tissue, Fibrous Histiocytoma 1 (2%) Subcutaneous Tissue, Melanoma Benign 1 (2%) 1 (2%) Subcutaneous Tissue, Control, Sarcoma 1 (2%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM None ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM Brain (50) (50) (50) Carcinoma, Metastatic, Pituitary Gland 1 (2%) ____________________________________________________________________________________________________________________________________ Page 5 NTP Experiment-Test: 55312-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 07/05/00 Route: SKIN APPLICATION Time: 15:00:52 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE 0 MG/KG 100 200 MG/KG MG/KG ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (50) (50) (50) Alveolar/Bronchiolar Adenoma 1 (2%) 3 (6%) Alveolar/Bronchiolar Adenoma, Multiple 1 (2%) 1 (2%) Alveolar/Bronchiolar Carcinoma 1 (2%) 1 (2%) Carcinoma, Metastatic, Harderian Gland 1 (2%) 2 (4%) Carcinoma, Metastatic, Thyroid Gland 1 (2%) Hepatoblastoma, Metastatic, Liver 1 (2%) 1 (2%) Hepatocellular Carcinoma, Metastatic, Liver 2 (4%) 3 (6%) 9 (18%) Histiocytic Sarcoma 1 (2%) 1 (2%) Mediastinum, Leiomyosarcoma, Metastatic, Intestine Small, Jejunum 1 (2%) Nose (50) (50) (49) Carcinoma, Metastatic, Harderian Gland 1 (2%) 1 (2%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM Eye (1) (2) (1) Carcinoma, Metastatic, Harderian Gland 1 (50%) Harderian Gland (1) (2) (1) Carcinoma 1 (100%) 2 (100%) 1 (100%) ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (50) (50) (50) Hepatoblastoma, Metastatic, Liver 1 (2%) Histiocytic Sarcoma 1 (2%) 1 (2%) Leiomyosarcoma, Metastatic, Intestine Small, Jejunum 1 (2%) Renal Tubule, Adenoma 1 (2%) Urinary Bladder (50) (50) (50) Hemangioma 1 (2%) ____________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS Multiple Organs *(50) *(50) *(50) Histiocytic Sarcoma 1 (2%) 2 (4%) 1 (2%) Lymphoma Malignant 13 (26%) 5 (10%) 7 (14%) ____________________________________________________________________________________________________________________________________ * Number of animals with any tissue examined microscopically Page 6 NTP Experiment-Test: 55312-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 07/05/00 Route: SKIN APPLICATION Time: 15:00:52 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE 0 MG/KG 100 200 MG/KG MG/KG ____________________________________________________________________________________________________________________________________ TUMOR SUMMARY Total Animals with Primary Neoplasms (b) 47 48 50 Total Primary Neoplasms 78 104 110 Total Animals with Benign Neoplasms 39 45 45 Total Benign Neoplasms 53 66 56 Total Animals with Malignant Neoplasms 23 30 41 Total Malignant Neoplasms 25 38 54 Total Animals with Metastatic Neoplasms 5 8 11 Total Metastatic Neoplasm 11 21 12 Total Animals with Malignant Neoplasms Uncertain Primary Site Total Animals with Neoplasms Uncertain- Benign or Malignant Total Uncertain Neoplasms ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion b Primary tumors: all tumors except metastatic tumors Page 7 NTP Experiment-Test: 55312-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 07/05/00 Route: SKIN APPLICATION Time: 15:00:52 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE 0 MG/KG 100 200 MG/KG MG/KG ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially in Study 50 50 50 Early Deaths Moribund Sacrifice 5 7 7 Natural Death 4 6 7 Survivors Terminal Sacrifice 41 37 36 Animals Examined Microscopically 50 50 50 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Intestine Large, Colon (50) (50) (50) Intestine Large, Cecum (50) (50) (50) Intestine Small, Duodenum (49) (50) (50) Hepatoblastoma, Metastatic, Liver 1 (2%) Intestine Small, Jejunum (50) (50) (50) Histiocytic Sarcoma 1 (2%) Liver (50) (50) (50) Alveolar/Bronchiolar Carcinoma, Metastatic, Lung 1 (2%) Hemangioma 1 (2%) Hemangiosarcoma 1 (2%) 2 (4%) Hemangiosarcoma, Multiple 1 (2%) 1 (2%) Hemangiosarcoma, Metastatic, Spleen 1 (2%) 1 (2%) Hepatoblastoma 1 (2%) 10 (20%) Hepatoblastoma, Multiple 1 (2%) Hepatocellular Carcinoma 7 (14%) 10 (20%) 12 (24%) Hepatocellular Carcinoma, Multiple 5 (10%) 2 (4%) 8 (16%) Hepatocellular Adenoma 11 (22%) 11 (22%) 4 (8%) Hepatocellular Adenoma, Multiple 11 (22%) 24 (48%) 41 (82%) Histiocytic Sarcoma 1 (2%) 2 (4%) Mast Cell Tumor Malignant, Metastatic, Skin 1 (2%) Mesentery (3) (3) (4) Hepatoblastoma, Metastatic, Liver 1 (33%) Hepatoblastoma, Metastatic, Pancreas 1 (25%) Histiocytic Sarcoma 1 (33%) 1 (33%) Oral Mucosa (1) Gingival, Squamous Cell Carcinoma 1 (100%) Pancreas (50) (50) (50) Hepatoblastoma, Metastatic, Liver 1 (2%) Page 8 NTP Experiment-Test: 55312-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 07/05/00 Route: SKIN APPLICATION Time: 15:00:52 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE 0 MG/KG 100 200 MG/KG MG/KG ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont Hepatoblastoma, Metastatic, Pancreas 1 (2%) Salivary Glands (50) (50) (50) Stomach, Forestomach (50) (50) (50) Hemangioma 1 (2%) Squamous Cell Papilloma 2 (4%) Stomach, Glandular (50) (50) (50) Hepatoblastoma, Metastatic, Liver 1 (2%) Histiocytic Sarcoma 1 (2%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Heart (50) (50) (50) Alveolar/Bronchiolar Carcinoma, Metastatic, Lung 1 (2%) 1 (2%) Histiocytic Sarcoma 1 (2%) ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (50) (50) (50) Islets, Pancreatic (50) (50) (50) Adenoma 1 (2%) 1 (2%) Pituitary Gland (45) (47) (49) Pars Distalis, Adenoma 1 (2%) Pars Intermedia, Adenoma 1 (2%) Thyroid Gland (50) (50) (50) Follicular Cell, Adenoma 1 (2%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Ductus Deferens (1) Epididymis (50) (50) (50) Histiocytic Sarcoma 1 (2%) Preputial Gland (49) (50) (50) Prostate (50) (50) (50) Seminal Vesicle (50) (49) (50) Page 9 NTP Experiment-Test: 55312-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 07/05/00 Route: SKIN APPLICATION Time: 15:00:52 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE 0 MG/KG 100 200 MG/KG MG/KG ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont Hemangiosarcoma 1 (2%) Histiocytic Sarcoma 1 (2%) Testes (50) (50) (50) Interstitial Cell, Adenoma 1 (2%) 1 (2%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Bone Marrow (50) (50) (50) Hemangiosarcoma, Metastatic, Liver 1 (2%) Hemangiosarcoma, Metastatic, Spleen 1 (2%) Histiocytic Sarcoma 1 (2%) Lymph Node (2) (5) (1) Lumbar, Alveolar/Bronchiolar Carcinoma, Metastatic, Lung 1 (20%) Mediastinal, Alveolar/Bronchiolar Carcinoma, Metastatic, Lung 1 (20%) Mediastinal, Histiocytic Sarcoma 1 (20%) Lymph Node, Mandibular (47) (45) (44) Lymph Node, Mesenteric (46) (48) (47) Hepatoblastoma, Metastatic, Liver 1 (2%) Histiocytic Sarcoma 1 (2%) 1 (2%) Spleen (50) (50) (50) Hemangiosarcoma 3 (6%) 1 (2%) Hepatoblastoma, Metastatic, Liver 1 (2%) Thymus (43) (44) (41) Histiocytic Sarcoma 1 (2%) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Skin (50) (50) (50) Histiocytic Sarcoma 1 (2%) Melanoma Malignant 1 (2%) Skin, Site of Application, Mast Cell Tumor Malignant 1 (2%) Subcutaneous Tissue, Hemangiosarcoma 1 (2%) ____________________________________________________________________________________________________________________________________ Page 10 NTP Experiment-Test: 55312-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 07/05/00 Route: SKIN APPLICATION Time: 15:00:52 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE 0 MG/KG 100 200 MG/KG MG/KG ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM Bone (50) (50) (50) Vertebra, Osteosarcoma 1 (2%) Skeletal Muscle (1) (3) Alveolar/Bronchiolar Carcinoma, Metastatic, Lung 1 (100%) Hepatoblastoma, Metastatic, Pancreas 1 (33%) ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM Brain (50) (50) (50) ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (50) (50) (50) Alveolar/Bronchiolar Adenoma 10 (20%) 7 (14%) 6 (12%) Alveolar/Bronchiolar Adenoma, Multiple 1 (2%) 3 (6%) 1 (2%) Alveolar/Bronchiolar Carcinoma 3 (6%) 2 (4%) 1 (2%) Alveolar/Bronchiolar Carcinoma, Multiple 1 (2%) 5 (10%) 2 (4%) Hepatoblastoma, Metastatic, Liver 1 (2%) 3 (6%) Hepatoblastoma, Metastatic, Pancreas 1 (2%) Hepatocellular Carcinoma, Metastatic, Liver 6 (12%) 2 (4%) 4 (8%) Histiocytic Sarcoma 2 (4%) Mediastinum, Alveolar/Bronchiolar Carcinoma, Metastatic, Lung 1 (2%) Serosa, Alveolar/Bronchiolar Carcinoma, Metastatic, Lung 1 (2%) Nose (50) (50) (50) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM Eye (1) (2) (1) Sarcoma 1 (100%) Harderian Gland (3) (3) (6) Adenoma 2 (67%) Carcinoma 2 (67%) 3 (50%) Bilateral, Carcinoma 1 (33%) 1 (17%) ____________________________________________________________________________________________________________________________________ Page 11 NTP Experiment-Test: 55312-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 07/05/00 Route: SKIN APPLICATION Time: 15:00:52 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE 0 MG/KG 100 200 MG/KG MG/KG ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (50) (50) (50) Alveolar/Bronchiolar Carcinoma, Metastatic, Lung 1 (2%) Hepatoblastoma, Metastatic, Liver 1 (2%) Histiocytic Sarcoma 1 (2%) Mast Cell Tumor Malignant, Metastatic, Skin 1 (2%) Renal Tubule, Adenoma 1 (2%) 1 (2%) 7 (14%) Renal Tubule, Carcinoma 2 (4%) Urinary Bladder (50) (50) (50) ____________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS Multiple Organs *(50) *(50) *(50) Histiocytic Sarcoma 1 (2%) 2 (4%) Lymphoma Malignant 2 (4%) 3 (6%) 3 (6%) ____________________________________________________________________________________________________________________________________ * Number of animals with any tissue examined microscopically Page 12 NTP Experiment-Test: 55312-04 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: CHRONIC COCONUT OIL ACID DIETHANOLAMINE CONDENSATE Date: 07/05/00 Route: SKIN APPLICATION Time: 15:00:52 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE 0 MG/KG 100 200 MG/KG MG/KG ____________________________________________________________________________________________________________________________________ TUMOR SUMMARY Total Animals with Primary Neoplasms (b) 35 45 50 Total Primary Neoplasms 65 80 113 Total Animals with Benign Neoplasms 26 39 47 Total Benign Neoplasms 38 49 65 Total Animals with Malignant Neoplasms 22 28 35 Total Malignant Neoplasms 27 31 48 Total Animals with Metastatic Neoplasms 9 3 12 Total Metastatic Neoplasm 17 9 16 Total Animals with Malignant Neoplasms Uncertain Primary Site Total Animals with Neoplasms Uncertain- Benign or Malignant Total Uncertain Neoplasms ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion b Primary tumors: all tumors except metastatic tumors Page 13 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------