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Title Bioavailability of seleno-compounds in the lactating rat
Creator/Author Smith, A.M. ; Picciano, M.F.
Publication Date1986 Mar 01
OSTI IdentifierOSTI ID: 5321458
Report Number(s)CONF-8604222-
Other Number(s)CODEN: FEPRA
Resource TypeConference
Specific TypeJournal Article
Resource RelationFed. Proc., Fed. Am. Soc. Exp. Biol. ; Vol/Issue: 45:3; 70. annual meeting of the Federation of American Society for Experimental Biology; 13 Apr 1986; St. Louis, MO, USA
Research OrgUniv. of Illinois, Urbana
Subject550500 -- Metabolism; PEROXIDASES-- ENZYME ACTIVITY;SELENIUM-- BIOLOGICAL AVAILABILITY; ANIMAL TISSUES;BLOOD;DIET;LACTATION;MILK;NUTRITIONAL DEFICIENCY;PREGNANCY;RATS
Related SubjectANIMALS;BIOLOGICAL MATERIALS;BODY;BODY FLUIDS;ELEMENTS;ENZYMES;FOOD;MAMMALS;MATERIALS;OXIDOREDUCTASES;RODENTS;SEMIMETALS;TISSUES;VERTEBRATES
Description/Abstract Previously the authors reported an increased selenium (Se) requirement for lactating rats of at least 0.2 ppm dietary Se if provided as selenite (SEL).^In the present study bioavailability of selenomethionine (SEM), Se yeast (SEY) and SEL was assessed.^A casein-based diet (0.025 ppm Se) was fed to 9 groups of 8 rats each during pregnancy to produce a marginal Se deficiency.^During lactation each group was fed the same diet containing either 0.1, 0.25, or 0.5 ppm Se as SEL, SEM, or SEY.^On day 18 of lactation dams and pups were sacrificed and tissue Se and glutathione peroxidase activities (GPx) determined.^Although food intake of the dams and growth of the pups did not vary, selenium and GPx activities were dependent upon quantity and form of Se consumed.^Using slope-ratio analysis linear increases in blood, tissue and milk Se content the bioavailabilities were SEM>SEY>SEL.^Maximal GPx depended on the form of dietary Se with SEM>SEY>SEL.^Maximal GPx occurred at 0.25 ppm dietary Se as SEM and SEY, but did not reach this activity when fed at 0.5 ppm Se as SEL.^These results indicate that regardless of form, the NRC requirement for growing rats of 0.1 ppm Se, is not adequate during lactation to maintain maximum tissue GSH-Px in nursing pups.^Based on higher tissue Se in dams and GPx in nursing pups the bioavailability of dietary Se to the lactating rat is greater when fed as SEM and SEY than as SEL.
Country of PublicationUnited States
LanguageEnglish
FormatPages: 589
System Entry Date2001 May 13

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