NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 MICE, FINAL#1 Facility: Southern Research Institute Chemical CAS #: 88-72-2 Lock Date: 03/08/99 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All Note: Animals arranged according to CID number Page 1 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| DAY ON TEST | 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| | 1| 1| 1| 1| 0| 2| 2| 2| 2| 2| 0| 2| 2| 2| 2| 1| 1| 1| 1| 1| 1| 1| 2| 1| 1| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | |__________________________________________________________________________| Gallbladder | + + + + + + + + + + + + + + + + + + + + + M + + +| Lymphoma Malignant | | |__________________________________________________________________________| Intestine Large, Colon | + + + + M + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Carcinoma | X | Hepatocellular Adenoma | X X X | Lymphoma Malignant | X | |__________________________________________________________________________| Mesentery | + + + | Lymphoma Malignant | | |__________________________________________________________________________| Oral Mucosa | + | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 2 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| DAY ON TEST | 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| | 1| 1| 1| 1| 0| 2| 2| 2| 2| 2| 0| 2| 2| 2| 2| 1| 1| 1| 1| 1| 1| 1| 2| 1| 1| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Hemangioma | X | Lymphoma Malignant | | Squamous Cell Papilloma | X | |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | |__________________________________________________________________________| Tooth | + + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | Epicardium, Lymphoma Malignant | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Capsule, Adenoma | | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Parathyroid Gland | + + + + M + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | Pars Distalis, Adenoma | X | |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | |__________________________________________________________________________| Tissue NOS | | __________________________________________|__________________________________________________________________________| Page 3 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| DAY ON TEST | 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| | 1| 1| 1| 1| 0| 2| 2| 2| 2| 2| 0| 2| 2| 2| 2| 1| 1| 1| 1| 1| 1| 1| 2| 1| 1| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + M + + + + + I| |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + I + + + + + + + +| Cystadenoma | X | Luteoma | X | Lymphoma Malignant | | |__________________________________________________________________________| Oviduct | | Lymphoma Malignant | | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangioma | | Lymphoma Malignant | | Endometrium, Polyp Stromal | X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | |__________________________________________________________________________| Lymph Node | + | Lymphoma Malignant | | Iliac, Lymphoma Malignant | | Inguinal, Lymphoma Malignant | | Mediastinal, Lymphoma Malignant | X | Pancreatic, Lymphoma Malignant | | Renal, Lymphoma Malignant | | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + I + + + + + + + + + + +| Lymphoma Malignant | | |__________________________________________________________________________| Lymph Node, Mesenteric | + + + M + + + + + + + + + + M + + + + + + + + + +| Lymphoma Malignant | X | Sarcoma | | |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 4 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| DAY ON TEST | 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| | 1| 1| 1| 1| 0| 2| 2| 2| 2| 2| 0| 2| 2| 2| 2| 1| 1| 1| 1| 1| 1| 1| 2| 1| 1| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Lymphoma Malignant | X | |__________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Subcutaneous Tissue, Lymphoma | | Malignant | | Subcutaneous Tissue, Sarcoma | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Skeletal Muscle | | Hemangioma | | Lymphoma Malignant | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X | Alveolar/Bronchiolar Carcinoma | X X | Lymphoma Malignant | X | Mediastinum, Lymphoma Malignant | | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | __________________________________________|__________________________________________________________________________| Page 5 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| DAY ON TEST | 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| | 1| 1| 1| 1| 0| 2| 2| 2| 2| 2| 0| 2| 2| 2| 2| 1| 1| 1| 1| 1| 1| 1| 2| 1| 1| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | |__________________________________________________________________________| Pleura | | |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Harderian Gland | + + + | Adenoma | X X | Carcinoma | X | |__________________________________________________________________________| Zymbal's Gland | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X X | __________________________________________|__________________________________________________________________________| Page 6 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 7| 5| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 9| 3| 6| 3| 3| | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 5| 2| 2| 2| 2| 9| 5| 2| 5| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | |__________________________________________________________________________| Gallbladder | + I + + + + + + + + + + + + + A + + + + A + A + +| Lymphoma Malignant | X | |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + A + + + + + + A + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + A + + + + + + A + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + A + + + + A + A + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + A + + + + A + A + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + A + + + + A + A + +| Lymphoma Malignant | X X | |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + A + + + + + + A + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Carcinoma | | Hepatocellular Adenoma | X X X | Lymphoma Malignant | X X X | |__________________________________________________________________________| Mesentery | + + + + + + | Lymphoma Malignant | X X X | |__________________________________________________________________________| Oral Mucosa | | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X X | |__________________________________________________________________________| Salivary Glands | M + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X X | |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 7 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 7| 5| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 9| 3| 6| 3| 3| | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 5| 2| 2| 2| 2| 9| 5| 2| 5| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Hemangioma | | Lymphoma Malignant | X | Squamous Cell Papilloma | | |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + A + +| Lymphoma Malignant | X | |__________________________________________________________________________| Tooth | + + + + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | Epicardium, Lymphoma Malignant | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + A + + + + + + + + +| Capsule, Adenoma | | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + A + + + + + + + + +| |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Parathyroid Gland | + + + + + + + + + M + + + + M + + + + + + + + + +| |__________________________________________________________________________| Pituitary Gland | + M + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Pars Distalis, Adenoma | X | |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | |__________________________________________________________________________| Tissue NOS | | __________________________________________|__________________________________________________________________________| Page 8 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 7| 5| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 9| 3| 6| 3| 3| | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 5| 2| 2| 2| 2| 9| 5| 2| 5| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Cystadenoma | | Luteoma | | Lymphoma Malignant | X X | |__________________________________________________________________________| Oviduct | + | Lymphoma Malignant | X | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangioma | | Lymphoma Malignant | X | Endometrium, Polyp Stromal | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | |__________________________________________________________________________| Lymph Node | + + + + | Lymphoma Malignant | X | Iliac, Lymphoma Malignant | X X X | Inguinal, Lymphoma Malignant | X X | Mediastinal, Lymphoma Malignant | X X X | Pancreatic, Lymphoma Malignant | X | Renal, Lymphoma Malignant | X X | |__________________________________________________________________________| Lymph Node, Mandibular | M + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X X X X | |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + I + + + + + + + + + M M + + +| Lymphoma Malignant | X X X X | Sarcoma | | |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + M + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 9 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 7| 5| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 9| 3| 6| 3| 3| | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 5| 2| 2| 2| 2| 9| 5| 2| 5| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Lymphoma Malignant | X X X X | |__________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X X X X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Subcutaneous Tissue, Lymphoma | | Malignant | X | Subcutaneous Tissue, Sarcoma | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Skeletal Muscle | + + | Hemangioma | X | Lymphoma Malignant | X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X| Alveolar/Bronchiolar Carcinoma | X | Lymphoma Malignant | X X X | Mediastinum, Lymphoma Malignant | X | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | __________________________________________|__________________________________________________________________________| Page 10 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 7| 5| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 9| 3| 6| 3| 3| | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 5| 2| 2| 2| 2| 9| 5| 2| 5| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | |__________________________________________________________________________| Pleura | | |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + M| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Harderian Gland | + + A | Adenoma | X X | Carcinoma | | |__________________________________________________________________________| Zymbal's Gland | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + A + +| Lymphoma Malignant | X X X | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X X | __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X X X X X | __________________________________________|__________________________________________________________________________| Page 11 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 4| 7| 7| 7| 3| 7| | | DAY ON TEST | 3| 3| 3| 3| 8| 3| 3| 3| 6| 3| | | | 5| 5| 5| 5| 3| 3| 3| 3| 2| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | A | 0 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + | 60 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Gallbladder | + + + + + + + + A + | 54 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + A + | 56 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + A + | 57 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + A + | 56 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + A + | 56 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + A + | 56 | Lymphoma Malignant | | 2 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + A + | 57 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + | 60 | Hepatocellular Carcinoma | X | 2 | Hepatocellular Adenoma | X | 7 | Lymphoma Malignant | X | 5 | |__________________________________________________________________________|____________| Mesentery | + + | 11 | Lymphoma Malignant | X | 4 | |__________________________________________________________________________|____________| Oral Mucosa | | 1 | |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + | 60 | Lymphoma Malignant | | 2 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 12 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 4| 7| 7| 7| 3| 7| | | DAY ON TEST | 3| 3| 3| 3| 8| 3| 3| 3| 6| 3| | | | 5| 5| 5| 5| 3| 3| 3| 3| 2| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | A | 0 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | | | | Salivary Glands | + + + + + + + + + + | 59 | Lymphoma Malignant | X | 3 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + | 60 | Hemangioma | | 1 | Lymphoma Malignant | X | 2 | Squamous Cell Papilloma | | 1 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + A + | 58 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Tooth | + + | 8 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + | 60 | Lymphoma Malignant | | 1 | Epicardium, Lymphoma Malignant | X | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + | 59 | Capsule, Adenoma | X | 1 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + | 59 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + | 60 | |__________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + | 57 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + A + | 58 | Adenoma | | 1 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 13 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 4| 7| 7| 7| 3| 7| | | DAY ON TEST | 3| 3| 3| 3| 8| 3| 3| 3| 6| 3| | | | 5| 5| 5| 5| 3| 3| 3| 3| 2| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | A | 0 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | | | | Pars Distalis, Adenoma | | 2 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + | 60 | Lymphoma Malignant | | 2 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | |__________________________________________________________________________|____________| Tissue NOS | + | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + | 58 | |__________________________________________________________________________|____________| Ovary | + + + + + + + + + + | 59 | Cystadenoma | | 1 | Luteoma | X | 2 | Lymphoma Malignant | | 2 | |__________________________________________________________________________|____________| Oviduct | | 1 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Uterus | + + + + + + + + + + | 60 | Hemangioma | X | 1 | Lymphoma Malignant | X | 2 | Endometrium, Polyp Stromal | X | 2 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + | 60 | Lymphoma Malignant | X | 1 | |__________________________________________________________________________|____________| Lymph Node | + | 6 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 14 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 4| 7| 7| 7| 3| 7| | | DAY ON TEST | 3| 3| 3| 3| 8| 3| 3| 3| 6| 3| | | | 5| 5| 5| 5| 3| 3| 3| 3| 2| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | A | 0 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | | | | Lymphoma Malignant | | 1 | Iliac, Lymphoma Malignant | | 3 | Inguinal, Lymphoma Malignant | X | 3 | Mediastinal, Lymphoma Malignant | | 4 | Pancreatic, Lymphoma Malignant | | 1 | Renal, Lymphoma Malignant | | 2 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + | 58 | Lymphoma Malignant | | 4 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + M + + + + + + + I | 53 | Lymphoma Malignant | | 5 | Sarcoma | X | 1 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 59 | Lymphoma Malignant | X | 6 | |__________________________________________________________________________|____________| Thymus | + I + + M + + + + M | 57 | Lymphoma Malignant | | 4 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + | 60 | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + | 60 | Subcutaneous Tissue, Lymphoma | | | Malignant | | 1 | Subcutaneous Tissue, Sarcoma | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + | 60 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 15 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 4| 7| 7| 7| 3| 7| | | DAY ON TEST | 3| 3| 3| 3| 8| 3| 3| 3| 6| 3| | | | 5| 5| 5| 5| 3| 3| 3| 3| 2| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | A | 0 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| MUSCULOSKELETAL SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Skeletal Muscle | | 2 | Hemangioma | | 1 | Lymphoma Malignant | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + | 60 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + | 60 | Alveolar/Bronchiolar Adenoma | | 2 | Alveolar/Bronchiolar Carcinoma | | 3 | Lymphoma Malignant | X | 5 | Mediastinum, Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Nose | + + + + + + + + + + | 60 | Lymphoma Malignant | X | 1 | |__________________________________________________________________________|____________| Pleura | + | 1 | |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + | 59 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Harderian Gland | | 5 | Adenoma | | 4 | Carcinoma | | 1 | |__________________________________________________________________________|____________| Zymbal's Gland | | 1 | _____________________________________________________________________________________________________________________| | * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 16 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 4| 7| 7| 7| 3| 7| | | DAY ON TEST | 3| 3| 3| 3| 8| 3| 3| 3| 6| 3| | | | 5| 5| 5| 5| 3| 3| 3| 3| 2| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | A | 0 PPM | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 59 | Lymphoma Malignant | | 3 | |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + A + | 59 | Lymphoma Malignant | X | 3 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + | 60 | Lymphoma Malignant | X | 8 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 17 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 _____________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 5| 3| 3| 2| 3| 3| 1| 4| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | 8| 1| 1| 3| 1| 2| 2| 4| 2| 2| 5| 2| 5| 5| 5| 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1250 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Gallbladder | A + + A + + + M + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | A + + + + + + A + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + A + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | A + + A + + + A + + + + + + + + + + + + + + + + +| Carcinoma | | |__________________________________________________________________________| Intestine Small, Duodenum | A + + A + + + A + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | A + + A + + + A + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Ileum | A + + A + + + A + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | |__________________________________________________________________________| Liver | + + + + + + + A + + + + + + + + + + + + + + + + +| Hepatocellular Carcinoma | X | Hepatocellular Carcinoma, Multiple | | Hepatocellular Adenoma | X X X | Histiocytic Sarcoma | X | Lymphoma Malignant | X X| Osteosarcoma, Metastatic, Bone | | |__________________________________________________________________________| Mesentery | + + + + | Carcinoma, Metastatic, Uncertain | | Primary Site | | Histiocytic Sarcoma | | Lymphoma Malignant | X | |__________________________________________________________________________| Pancreas | A + + + + + + A + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | |__________________________________________________________________________| Salivary Glands | + + + + + + + M + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 18 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 _____________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 5| 3| 3| 2| 3| 3| 1| 4| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | 8| 1| 1| 3| 1| 2| 2| 4| 2| 2| 5| 2| 5| 5| 5| 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1250 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | |__________________________________________________________________________| Stomach, Forestomach | A + + + + + + + + + + + + + + + + + + + + + + + +| Squamous Cell Papilloma | | |__________________________________________________________________________| Stomach, Glandular | A + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Tooth | + + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Uncertain | | Primary Site | | Epicardium, Lymphoma Malignant | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | A + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Adrenal Medulla | A + + + + + + + + + + + + + + + + + + + + + + + +| Pheochromocytoma Benign | | |__________________________________________________________________________| Islets, Pancreatic | A + + + + + + A + + + + + + + + + + + + + + + + +| Carcinoma | | |__________________________________________________________________________| Parathyroid Gland | + + + M M + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Pituitary Gland | M + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Adenoma | X X| |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Follicular Cell, Adenoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | __________________________________________|__________________________________________________________________________| Page 19 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 _____________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 5| 3| 3| 2| 3| 3| 1| 4| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | 8| 1| 1| 3| 1| 2| 2| 4| 2| 2| 5| 2| 5| 5| 5| 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1250 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Ovary | A + + A + + + + + + + + + + + + + + + M + + + + +| Carcinoma | | Hemangiosarcoma | | Histiocytic Sarcoma | | Tubulostromal Adenoma | | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangioma | | Hemangiosarcoma | X | Histiocytic Sarcoma | | Leiomyoma | X | Endometrium, Polyp Stromal | X X | |__________________________________________________________________________| Vagina | | Carcinoma, Metastatic, Uncertain | | Primary Site | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | A + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Uncertain | | Primary Site | | Histiocytic Sarcoma | | |__________________________________________________________________________| Lymph Node | + +| Inguinal, Lymphoma Malignant | X | Pancreatic, Lymphoma Malignant | X| Renal, Lymphoma Malignant | X | |__________________________________________________________________________| Lymph Node, Mandibular | A + + + + + + M + + + + M + + + + + + + + + + + +| Lymphoma Malignant | X | |__________________________________________________________________________| Lymph Node, Mesenteric | A + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | __________________________________________|__________________________________________________________________________| Page 20 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 _____________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 5| 3| 3| 2| 3| 3| 1| 4| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | 8| 1| 1| 3| 1| 2| 2| 4| 2| 2| 5| 2| 5| 5| 5| 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1250 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Lymphoma Malignant | X X| |__________________________________________________________________________| Spleen | M + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X X X X| |__________________________________________________________________________| Thymus | M + + + + I + + + + + + + + + + + + + + + + + + M| Lymphoma Malignant | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Basosquamous Tumor Malignant | | Subcutaneous Tissue, Carcinoma, | | Multiple | | Subcutaneous Tissue, Sarcoma | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Osteosarcoma | | |__________________________________________________________________________| Skeletal Muscle | + | Carcinoma, Metastatic, Uncertain | | Primary Site | | Sarcoma | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Peripheral Nerve | | |__________________________________________________________________________| Spinal Cord | | _____________________________________________________________________________________________________________________| Page 21 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 _____________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 5| 3| 3| 2| 3| 3| 1| 4| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | 8| 1| 1| 3| 1| 2| 2| 4| 2| 2| 5| 2| 5| 5| 5| 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1250 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X | Alveolar/Bronchiolar Carcinoma | | Alveolar/Bronchiolar Carcinoma, | | Multiple | | Carcinoma, Metastatic, Harderian | | Gland | X | Carcinoma, Metastatic, Uncertain | | Primary Site | | Hepatocellular Carcinoma, Metastatic,| | Liver | | Histiocytic Sarcoma | X | Lymphoma Malignant | X X | Osteosarcoma, Metastatic, Bone | | Mediastinum, Alveolar/Bronchiolar | | Carcinoma, Metastatic, Lung | X | Mediastinum, Carcinoma | | Mediastinum, Carcinoma, Metastatic, | | Harderian Gland | X | Mediastinum, Lymphoma Malignant | X | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Harderian Gland | + | Carcinoma | X | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | A + + + + + + A + + + + + + + + + + + + + + + + +| Carcinoma | | Histiocytic Sarcoma | | Lymphoma Malignant | X X X| __________________________________________|__________________________________________________________________________| Page 22 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 _____________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 5| 3| 3| 2| 3| 3| 1| 4| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | 8| 1| 1| 3| 1| 2| 2| 4| 2| 2| 5| 2| 5| 5| 5| 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1250 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| URINARY SYSTEM - cont | | | | |__________________________________________________________________________| Urinary Bladder | M + + M + + + A + + + + + + + + + + + + + + + + M| __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | Lymphoma Malignant | X X X X| __________________________________________|__________________________________________________________________________| Page 23 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7| DAY ON TEST | 3| 3| 3| 7| 3| 3| 6| 3| 3| 3| 0| 3| 3| 6| 2| 3| 3| 3| 3| 3| 3| 3| 5| 9| 3| | 3| 3| 3| 9| 3| 5| 0| 5| 5| 5| 8| 5| 5| 6| 1| 2| 2| 2| 2| 2| 5| 5| 3| 7| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1250 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Gallbladder | + + + + + + + + + + A + + A + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + A + + A + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + A + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + A + + + A + + A + + + + + + + + + + +| Carcinoma | | |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + A + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + A + + + A + + A + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + A + + + A + + A + + + + + + + + + + +| Lymphoma Malignant | | |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Carcinoma | X | Hepatocellular Carcinoma, Multiple | | Hepatocellular Adenoma | X X | Histiocytic Sarcoma | X | Lymphoma Malignant | X | Osteosarcoma, Metastatic, Bone | X | |__________________________________________________________________________| Mesentery | + + + +| Carcinoma, Metastatic, Uncertain | | Primary Site | X | Histiocytic Sarcoma | X | Lymphoma Malignant | | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + A + + + + + + + + + + +| Lymphoma Malignant | | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 24 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7| DAY ON TEST | 3| 3| 3| 7| 3| 3| 6| 3| 3| 3| 0| 3| 3| 6| 2| 3| 3| 3| 3| 3| 3| 3| 5| 9| 3| | 3| 3| 3| 9| 3| 5| 0| 5| 5| 5| 8| 5| 5| 6| 1| 2| 2| 2| 2| 2| 5| 5| 3| 7| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1250 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + A + + + + + + + + + + +| Squamous Cell Papilloma | X | |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + A + + + + + + + + + + +| |__________________________________________________________________________| Tooth | + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Uncertain | | Primary Site | X | Epicardium, Lymphoma Malignant | X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Adrenal Medulla | + + + + + + M + + + + + + + + + + I + + + + + + +| Pheochromocytoma Benign | X | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + A + + + + + + + + + + +| Carcinoma | X | |__________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + M + + + + +| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Adenoma | X X | |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + M + + + + +| Follicular Cell, Adenoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | __________________________________________|__________________________________________________________________________| Page 25 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7| DAY ON TEST | 3| 3| 3| 7| 3| 3| 6| 3| 3| 3| 0| 3| 3| 6| 2| 3| 3| 3| 3| 3| 3| 3| 5| 9| 3| | 3| 3| 3| 9| 3| 5| 0| 5| 5| 5| 8| 5| 5| 6| 1| 2| 2| 2| 2| 2| 5| 5| 3| 7| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1250 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | I + + M + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + A + + + + + + + + + + +| Carcinoma | X | Hemangiosarcoma | | Histiocytic Sarcoma | X | Tubulostromal Adenoma | X| |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + A + + + + + + + + + + +| Hemangioma | X X | Hemangiosarcoma | | Histiocytic Sarcoma | X | Leiomyoma | | Endometrium, Polyp Stromal | | |__________________________________________________________________________| Vagina | + | Carcinoma, Metastatic, Uncertain | | Primary Site | X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + A + + + + + + + + + + +| Carcinoma, Metastatic, Uncertain | | Primary Site | X | Histiocytic Sarcoma | X | |__________________________________________________________________________| Lymph Node | | Inguinal, Lymphoma Malignant | | Pancreatic, Lymphoma Malignant | | Renal, Lymphoma Malignant | | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + M + + + + + + A + + + + + + + + + + +| Lymphoma Malignant | | |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + A + + + + + + + + + + +| Histiocytic Sarcoma | X | __________________________________________|__________________________________________________________________________| Page 26 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7| DAY ON TEST | 3| 3| 3| 7| 3| 3| 6| 3| 3| 3| 0| 3| 3| 6| 2| 3| 3| 3| 3| 3| 3| 3| 5| 9| 3| | 3| 3| 3| 9| 3| 5| 0| 5| 5| 5| 8| 5| 5| 6| 1| 2| 2| 2| 2| 2| 5| 5| 3| 7| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1250 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Lymphoma Malignant | X | |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + A + + + + + + + + + + +| Lymphoma Malignant | X | |__________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + M +| Lymphoma Malignant | X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + I + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Basosquamous Tumor Malignant | X | Subcutaneous Tissue, Carcinoma, | | Multiple | X | Subcutaneous Tissue, Sarcoma | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Osteosarcoma | X | |__________________________________________________________________________| Skeletal Muscle | + + | Carcinoma, Metastatic, Uncertain | | Primary Site | X | Sarcoma | X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Peripheral Nerve | + | |__________________________________________________________________________| Spinal Cord | + | _____________________________________________________________________________________________________________________| Page 27 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7| DAY ON TEST | 3| 3| 3| 7| 3| 3| 6| 3| 3| 3| 0| 3| 3| 6| 2| 3| 3| 3| 3| 3| 3| 3| 5| 9| 3| | 3| 3| 3| 9| 3| 5| 0| 5| 5| 5| 8| 5| 5| 6| 1| 2| 2| 2| 2| 2| 5| 5| 3| 7| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1250 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X | Alveolar/Bronchiolar Carcinoma | X | Alveolar/Bronchiolar Carcinoma, | | Multiple | X | Carcinoma, Metastatic, Harderian | | Gland | | Carcinoma, Metastatic, Uncertain | | Primary Site | X | Hepatocellular Carcinoma, Metastatic,| | Liver | | Histiocytic Sarcoma | | Lymphoma Malignant | X | Osteosarcoma, Metastatic, Bone | X | Mediastinum, Alveolar/Bronchiolar | | Carcinoma, Metastatic, Lung | | Mediastinum, Carcinoma | X | Mediastinum, Carcinoma, Metastatic, | | Harderian Gland | | Mediastinum, Lymphoma Malignant | | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + M + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Harderian Gland | | Carcinoma | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + A + + + + + + + + + + +| Carcinoma | X | Histiocytic Sarcoma | X | Lymphoma Malignant | | __________________________________________|__________________________________________________________________________| Page 28 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7| DAY ON TEST | 3| 3| 3| 7| 3| 3| 6| 3| 3| 3| 0| 3| 3| 6| 2| 3| 3| 3| 3| 3| 3| 3| 5| 9| 3| | 3| 3| 3| 9| 3| 5| 0| 5| 5| 5| 8| 5| 5| 6| 1| 2| 2| 2| 2| 2| 5| 5| 3| 7| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1250 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| URINARY SYSTEM - cont | | | | |__________________________________________________________________________| Urinary Bladder | + + + + + + A + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | Lymphoma Malignant | X X | __________________________________________|__________________________________________________________________________| Page 29 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 __________________________________________________________________________________________________________________________________ | 7| 7| 3| 7| 7| 7| 7| 7| 3| 7| | | DAY ON TEST | 3| 3| 4| 3| 3| 3| 3| 3| 1| 3| | | | 2| 2| 3| 2| 2| 5| 5| 5| 2| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A | 1250 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + | 60 | |__________________________________________________________________________|____________| Gallbladder | + M A + + + + + + + | 53 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + A + + + + + + + | 55 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + A + + + + + + + | 57 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + A + + + + + + + | 53 | Carcinoma | X | 1 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + A + + + + + + + | 55 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + A + + + + + + + | 53 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + A + + + + + + + | 53 | Lymphoma Malignant | X | 1 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + | 59 | Hepatocellular Carcinoma | X | 3 | Hepatocellular Carcinoma, Multiple | X | 1 | Hepatocellular Adenoma | | 5 | Histiocytic Sarcoma | | 2 | Lymphoma Malignant | | 3 | Osteosarcoma, Metastatic, Bone | | 1 | |__________________________________________________________________________|____________| Mesentery | + | 9 | Carcinoma, Metastatic, Uncertain | | | Primary Site | | 1 | Histiocytic Sarcoma | | 1 | Lymphoma Malignant | X | 2 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 30 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 __________________________________________________________________________________________________________________________________ | 7| 7| 3| 7| 7| 7| 7| 7| 3| 7| | | DAY ON TEST | 3| 3| 4| 3| 3| 3| 3| 3| 1| 3| | | | 2| 2| 3| 2| 2| 5| 5| 5| 2| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A | 1250 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | | | | Pancreas | + + + + + + + + + + | 57 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + | 59 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + | 58 | Squamous Cell Papilloma | X | 2 | |__________________________________________________________________________|____________| Stomach, Glandular | + + A + + + + + + + | 57 | |__________________________________________________________________________|____________| Tooth | + | 4 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | | 2 | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + | 60 | Carcinoma, Metastatic, Uncertain | | | Primary Site | | 1 | Epicardium, Lymphoma Malignant | | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + | 59 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + | 57 | Pheochromocytoma Benign | | 1 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + | 57 | Carcinoma | | 1 | |__________________________________________________________________________|____________| Parathyroid Gland | M + M + + + + + + + | 55 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 31 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 __________________________________________________________________________________________________________________________________ | 7| 7| 3| 7| 7| 7| 7| 7| 3| 7| | | DAY ON TEST | 3| 3| 4| 3| 3| 3| 3| 3| 1| 3| | | | 2| 2| 3| 2| 2| 5| 5| 5| 2| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A | 1250 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Pituitary Gland | + + I + + + + + + + | 58 | Pars Distalis, Adenoma | | 4 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + | 59 | Follicular Cell, Adenoma | | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Clitoral Gland | + + + + + M + + + + | 57 | |__________________________________________________________________________|____________| Ovary | + + + + + + + + + + | 56 | Carcinoma | | 1 | Hemangiosarcoma | X | 1 | Histiocytic Sarcoma | | 1 | Tubulostromal Adenoma | | 1 | |__________________________________________________________________________|____________| Uterus | + + + + + + + + + + | 59 | Hemangioma | | 2 | Hemangiosarcoma | | 1 | Histiocytic Sarcoma | | 1 | Leiomyoma | | 1 | Endometrium, Polyp Stromal | | 2 | |__________________________________________________________________________|____________| Vagina | | 1 | Carcinoma, Metastatic, Uncertain | | | Primary Site | | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 32 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 __________________________________________________________________________________________________________________________________ | 7| 7| 3| 7| 7| 7| 7| 7| 3| 7| | | DAY ON TEST | 3| 3| 4| 3| 3| 3| 3| 3| 1| 3| | | | 2| 2| 3| 2| 2| 5| 5| 5| 2| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A | 1250 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + | 58 | Carcinoma, Metastatic, Uncertain | | | Primary Site | | 1 | Histiocytic Sarcoma | | 1 | |__________________________________________________________________________|____________| Lymph Node | + | 3 | Inguinal, Lymphoma Malignant | | 1 | Pancreatic, Lymphoma Malignant | | 1 | Renal, Lymphoma Malignant | X | 2 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + | 55 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + | 58 | Histiocytic Sarcoma | | 1 | Lymphoma Malignant | X | 4 | |__________________________________________________________________________|____________| Spleen | + + A + + + + + + + | 57 | Lymphoma Malignant | X | 6 | |__________________________________________________________________________|____________| Thymus | + + + + + + + + + + | 56 | Lymphoma Malignant | | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + | 59 | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + | 60 | Basosquamous Tumor Malignant | | 1 | Subcutaneous Tissue, Carcinoma, | | | Multiple | | 1 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 33 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 __________________________________________________________________________________________________________________________________ | 7| 7| 3| 7| 7| 7| 7| 7| 3| 7| | | DAY ON TEST | 3| 3| 4| 3| 3| 3| 3| 3| 1| 3| | | | 2| 2| 3| 2| 2| 5| 5| 5| 2| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A | 1250 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| INTEGUMENTARY SYSTEM - cont | | | | | | Subcutaneous Tissue, Sarcoma | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + | 60 | Osteosarcoma | | 1 | |__________________________________________________________________________|____________| Skeletal Muscle | | 3 | Carcinoma, Metastatic, Uncertain | | | Primary Site | | 1 | Sarcoma | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + | 60 | |__________________________________________________________________________|____________| Peripheral Nerve | + | 2 | |__________________________________________________________________________|____________| Spinal Cord | + | 2 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + | 60 | Alveolar/Bronchiolar Adenoma | X | 3 | Alveolar/Bronchiolar Carcinoma | | 1 | Alveolar/Bronchiolar Carcinoma, | | | Multiple | X | 2 | Carcinoma, Metastatic, Harderian | | | Gland | | 1 | Carcinoma, Metastatic, Uncertain | | | Primary Site | | 1 | Hepatocellular Carcinoma, Metastatic,| | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 34 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 __________________________________________________________________________________________________________________________________ | 7| 7| 3| 7| 7| 7| 7| 7| 3| 7| | | DAY ON TEST | 3| 3| 4| 3| 3| 3| 3| 3| 1| 3| | | | 2| 2| 3| 2| 2| 5| 5| 5| 2| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A | 1250 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| RESPIRATORY SYSTEM - cont | | | | | | Liver | X | 1 | Histiocytic Sarcoma | | 1 | Lymphoma Malignant | | 3 | Osteosarcoma, Metastatic, Bone | | 1 | Mediastinum, Alveolar/Bronchiolar | | | Carcinoma, Metastatic, Lung | | 1 | Mediastinum, Carcinoma | | 1 | Mediastinum, Carcinoma, Metastatic, | | | Harderian Gland | | 1 | Mediastinum, Lymphoma Malignant | X | 2 | |__________________________________________________________________________|____________| Nose | + + + + + + + + + + | 60 | |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + | 59 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Harderian Gland | | 1 | Carcinoma | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + A + + + + + + + | 56 | Carcinoma | | 1 | Histiocytic Sarcoma | | 1 | Lymphoma Malignant | | 3 | |__________________________________________________________________________|____________| Urinary Bladder | + + A + + + + + + + | 54 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + | 60 | Histiocytic Sarcoma | | 2 | Lymphoma Malignant | X | 7 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 35 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| DAY ON TEST | 3| 3| 0| 1| 3| 3| 3| 9| 3| 1| 3| 3| 1| 3| 2| 3| 3| 3| 3| 3| 3| 6| 3| 3| 0| | 5| 5| 1| 8| 5| 1| 1| 0| 1| 0| 2| 2| 5| 2| 4| 2| 2| 2| 2| 2| 3| 1| 3| 3| 1| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2500 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Gallbladder | + + A A + + + + M + + + + + + + + + + + + + + + A| |__________________________________________________________________________| Intestine Large, Colon | + + A + + + + + + + + + + + + + + + + + + + + + A| |__________________________________________________________________________| Intestine Large, Rectum | + + + A + + + + + + + + + + + + + + + + + + + + A| |__________________________________________________________________________| Intestine Large, Cecum | M + A A + + + + + + + + + + + + + + + + + M + + A| Carcinoma | X X X | Sarcoma | | |__________________________________________________________________________| Intestine Small, Duodenum | + + A + + + + + + + + + + + + + + + + + + + + + A| |__________________________________________________________________________| Intestine Small, Jejunum | + + A A + + + + + + + + + + + + + + + + + + + + A| |__________________________________________________________________________| Intestine Small, Ileum | + + A A + + + + + + + + + + + + + + + + + + + + A| |__________________________________________________________________________| Liver | + + A + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | | Hepatocellular Carcinoma | X X X X | Hepatocellular Carcinoma, Multiple | | Hepatocellular Adenoma | X X X X | Hepatocellular Adenoma, Multiple | X X | Histiocytic Sarcoma | X| Lymphoma Malignant | X | Sarcoma, Metastatic, Uncertain | | Primary Site | | |__________________________________________________________________________| Mesentery | + + + | Carcinoma, Metastatic, Intestine | | Large, Cecum | X | Sarcoma, Multiple | | Sarcoma, Metastatic, Skin | | Sarcoma, Metastatic, Skeletal Muscle | | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 36 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| DAY ON TEST | 3| 3| 0| 1| 3| 3| 3| 9| 3| 1| 3| 3| 1| 3| 2| 3| 3| 3| 3| 3| 3| 6| 3| 3| 0| | 5| 5| 1| 8| 5| 1| 1| 0| 1| 0| 2| 2| 5| 2| 4| 2| 2| 2| 2| 2| 3| 1| 3| 3| 1| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2500 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Pancreas | + + A + + + + + + + + + + + + + + + + + + + + + +| Sarcoma | | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X| |__________________________________________________________________________| Stomach, Forestomach | + + A + + + + + + + + + + + + + + + + + + + + + +| Squamous Cell Papilloma | X | |__________________________________________________________________________| Stomach, Glandular | + + A + + + + + + + + + + + + + + + + + + + + + A| Sarcoma | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + A + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Adrenal Medulla | + + A + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Parathyroid Gland | M + + + + + + + + M + + + + + + + + + + + + + + +| |__________________________________________________________________________| Pituitary Gland | + + A + + + + + + + + + + + + + + + + + + + M M +| Pars Distalis, Adenoma | | Pars Intermedia, Adenoma | | |__________________________________________________________________________| Thyroid Gland | I + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 37 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| DAY ON TEST | 3| 3| 0| 1| 3| 3| 3| 9| 3| 1| 3| 3| 1| 3| 2| 3| 3| 3| 3| 3| 3| 6| 3| 3| 0| | 5| 5| 1| 8| 5| 1| 1| 0| 1| 0| 2| 2| 5| 2| 4| 2| 2| 2| 2| 2| 3| 1| 3| 3| 1| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2500 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| GENERAL BODY SYSTEM - cont | | | | Tissue NOS | + | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Ovary | + + A + + + + + + + + + + + + + + + + + + + + + +| Cystadenoma | | Luteoma | | Teratoma Malignant | | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X| Leiomyosarcoma | | Endometrium, Carcinoma | X | Endometrium, Polyp Stromal | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X| |__________________________________________________________________________| Lymph Node | + + + + + | Lymphoma Malignant | X | Iliac, Lymphoma Malignant | X | Inguinal, Lymphoma Malignant | X | Inguinal, Sarcoma, Metastatic, Skin | | Mediastinal, Lymphoma Malignant | X | Pancreatic, Lymphoma Malignant | X X | Pancreatic, Sarcoma | | Renal, Lymphoma Malignant | X | Renal, Sarcoma, Metastatic, Skin | | |__________________________________________________________________________| Lymph Node, Mandibular | M + + + + + + + + + + + + M + + + + + + + + + + +| Histiocytic Sarcoma | X| Lymphoma Malignant | X X | __________________________________________|__________________________________________________________________________| Page 38 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| DAY ON TEST | 3| 3| 0| 1| 3| 3| 3| 9| 3| 1| 3| 3| 1| 3| 2| 3| 3| 3| 3| 3| 3| 6| 3| 3| 0| | 5| 5| 1| 8| 5| 1| 1| 0| 1| 0| 2| 2| 5| 2| 4| 2| 2| 2| 2| 2| 3| 1| 3| 3| 1| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2500 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | |__________________________________________________________________________| Lymph Node, Mesenteric | + + A + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X| Lymphoma Malignant | X | |__________________________________________________________________________| Spleen | + + A + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X| Lymphoma Malignant | X X | |__________________________________________________________________________| Thymus | + + A M + + + + + + + + + + + + + + + + + + + + I| Lymphoma Malignant | X | Thymoma Malignant | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Subcutaneous Tissue, Hemangiosarcoma | X X | Subcutaneous Tissue, Sarcoma | X X X | Subcutaneous Tissue, Sarcoma, | | Multiple | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Femur, Osteosarcoma | X | |__________________________________________________________________________| Skeletal Muscle | + | Sarcoma | X | Sarcoma, Multiple | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 39 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| DAY ON TEST | 3| 3| 0| 1| 3| 3| 3| 9| 3| 1| 3| 3| 1| 3| 2| 3| 3| 3| 3| 3| 3| 6| 3| 3| 0| | 5| 5| 1| 8| 5| 1| 1| 0| 1| 0| 2| 2| 5| 2| 4| 2| 2| 2| 2| 2| 3| 1| 3| 3| 1| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2500 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| NERVOUS SYSTEM - cont | | | | Peripheral Nerve | + | |__________________________________________________________________________| Spinal Cord | + | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X X| Histiocytic Sarcoma | X| Osteosarcoma, Metastatic, Bone | X | Sarcoma, Metastatic, Skeletal Muscle | | Teratoma Malignant, Metastatic, Ovary| | Mediastinum, Histiocytic Sarcoma | X| Mediastinum, Sarcoma, Metastatic, | | Uncertain Primary Site | | Mediastinum, Sarcoma, Metastatic, | | Skeletal Muscle | | |__________________________________________________________________________| Nose | + + A + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Harderian Gland | | Adenoma | | Carcinoma | | |__________________________________________________________________________| Lacrimal Gland | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + A + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | |__________________________________________________________________________| Urinary Bladder | + + M + M + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 40 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 __________________________________________|__________________________________________________________________________ | 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| DAY ON TEST | 3| 3| 0| 1| 3| 3| 3| 9| 3| 1| 3| 3| 1| 3| 2| 3| 3| 3| 3| 3| 3| 6| 3| 3| 0| | 5| 5| 1| 8| 5| 1| 1| 0| 1| 0| 2| 2| 5| 2| 4| 2| 2| 2| 2| 2| 3| 1| 3| 3| 1| _____________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2500 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X| Lymphoma Malignant | X X X | __________________________________________|__________________________________________________________________________| Page 41 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| | 3| 3| 3| 3| 3| 1| 1| 1| 1| 1| 3| 3| 3| 3| 3| 2| 9| 2| 2| 2| 1| 1| 1| 1| 1| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2500 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + M + + + + + + + +| |__________________________________________________________________________| Gallbladder | + + + + + + + + + A + + + + + + A + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + A + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + A + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + A + + + + + + + +| Carcinoma | X | Sarcoma | | |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + A + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + A + + + + + + + +| |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + A + + + + + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | Hepatocellular Carcinoma | | Hepatocellular Carcinoma, Multiple | X | Hepatocellular Adenoma | X X X X X X X X | Hepatocellular Adenoma, Multiple | | Histiocytic Sarcoma | | Lymphoma Malignant | X | Sarcoma, Metastatic, Uncertain | | Primary Site | | |__________________________________________________________________________| Mesentery | + + + | Carcinoma, Metastatic, Intestine | | Large, Cecum | | Sarcoma, Multiple | | Sarcoma, Metastatic, Skin | X | Sarcoma, Metastatic, Skeletal Muscle | | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 42 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| | 3| 3| 3| 3| 3| 1| 1| 1| 1| 1| 3| 3| 3| 3| 3| 2| 9| 2| 2| 2| 1| 1| 1| 1| 1| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2500 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Pancreas | + + + + + + + + + + + + + + + + A + + + + + + + +| Sarcoma | | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + M + + + + + + + +| Histiocytic Sarcoma | | |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + A + + + + + + + +| Squamous Cell Papilloma | X | |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + A + + + + + + + +| Sarcoma | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + M + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + M + + + + + + + +| |__________________________________________________________________________| Pituitary Gland | M M + + + + + + + + + + + + + + M M + + + + + + +| Pars Distalis, Adenoma | X X | Pars Intermedia, Adenoma | X | |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + M + + + + + + + +| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 43 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| | 3| 3| 3| 3| 3| 1| 1| 1| 1| 1| 3| 3| 3| 3| 3| 2| 9| 2| 2| 2| 1| 1| 1| 1| 1| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2500 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| GENERAL BODY SYSTEM - cont | | | | Tissue NOS | + + | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + + I + M + + + + + + + M + + + + + + + +| |__________________________________________________________________________| Ovary | + + + + + + M + + + + + + + + + + + + + + + M + +| Cystadenoma | X | Luteoma | X | Teratoma Malignant | X| |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Leiomyosarcoma | | Endometrium, Carcinoma | | Endometrium, Polyp Stromal | X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | |__________________________________________________________________________| Lymph Node | + + | Lymphoma Malignant | | Iliac, Lymphoma Malignant | X | Inguinal, Lymphoma Malignant | X | Inguinal, Sarcoma, Metastatic, Skin | X | Mediastinal, Lymphoma Malignant | X | Pancreatic, Lymphoma Malignant | X | Pancreatic, Sarcoma | | Renal, Lymphoma Malignant | X | Renal, Sarcoma, Metastatic, Skin | X | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + I + M + + + + + + + +| Histiocytic Sarcoma | | Lymphoma Malignant | X | __________________________________________|__________________________________________________________________________| Page 44 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| | 3| 3| 3| 3| 3| 1| 1| 1| 1| 1| 3| 3| 3| 3| 3| 2| 9| 2| 2| 2| 1| 1| 1| 1| 1| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2500 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + I + + + + + + + A + + + + + + + +| Histiocytic Sarcoma | | Lymphoma Malignant | X | |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + A + + + + + + + +| Histiocytic Sarcoma | | Lymphoma Malignant | X | |__________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + M + + + + + + + +| Lymphoma Malignant | | Thymoma Malignant | X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Subcutaneous Tissue, Hemangiosarcoma | | Subcutaneous Tissue, Sarcoma | X X | Subcutaneous Tissue, Sarcoma, | | Multiple | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Femur, Osteosarcoma | | |__________________________________________________________________________| Skeletal Muscle | | Sarcoma | | Sarcoma, Multiple | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + M + + + + + + + +| |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 45 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| | 3| 3| 3| 3| 3| 1| 1| 1| 1| 1| 3| 3| 3| 3| 3| 2| 9| 2| 2| 2| 1| 1| 1| 1| 1| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2500 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| NERVOUS SYSTEM - cont | | | | Peripheral Nerve | | |__________________________________________________________________________| Spinal Cord | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + M + + + + + + + +| Alveolar/Bronchiolar Adenoma | X | Histiocytic Sarcoma | | Osteosarcoma, Metastatic, Bone | | Sarcoma, Metastatic, Skeletal Muscle | | Teratoma Malignant, Metastatic, Ovary| X| Mediastinum, Histiocytic Sarcoma | | Mediastinum, Sarcoma, Metastatic, | | Uncertain Primary Site | | Mediastinum, Sarcoma, Metastatic, | | Skeletal Muscle | | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + M + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Harderian Gland | + | Adenoma | | Carcinoma | X | |__________________________________________________________________________| Lacrimal Gland | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + A + + + + + + + +| Lymphoma Malignant | X | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + M + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 46 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 __________________________________________|__________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| | 3| 3| 3| 3| 3| 1| 1| 1| 1| 1| 3| 3| 3| 3| 3| 2| 9| 2| 2| 2| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 2500 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| _____________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Lymphoma Malignant | X | __________________________________________|__________________________________________________________________________| Page 47 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 __________________________________________________________________________________________________________________________________ | 7| 7| 5| 7| 7| 7| 7| 7| 6| 6| | | DAY ON TEST | 3| 3| 5| 3| 3| 3| 3| 3| 7| 7| | | | 2| 2| 3| 2| 2| 5| 5| 5| 2| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A | 2500 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + | 59 | |__________________________________________________________________________|____________| Gallbladder | + + + + + + + + + + | 54 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + | 57 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + | 57 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + | 54 | Carcinoma | | 4 | Sarcoma | X | 1 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + | 57 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + | 56 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + | 56 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + | 59 | Hemangiosarcoma | | 1 | Hepatocellular Carcinoma | | 4 | Hepatocellular Carcinoma, Multiple | X | 2 | Hepatocellular Adenoma | X X X X | 16 | Hepatocellular Adenoma, Multiple | X | 3 | Histiocytic Sarcoma | | 1 | Lymphoma Malignant | | 2 | Sarcoma, Metastatic, Uncertain | | | Primary Site | X | 1 | |__________________________________________________________________________|____________| Mesentery | + + + | 9 | Carcinoma, Metastatic, Intestine | | | Large, Cecum | | 1 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 48 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 __________________________________________________________________________________________________________________________________ | 7| 7| 5| 7| 7| 7| 7| 7| 6| 6| | | DAY ON TEST | 3| 3| 5| 3| 3| 3| 3| 3| 7| 7| | | | 2| 2| 3| 2| 2| 5| 5| 5| 2| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A | 2500 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | | | | Sarcoma, Multiple | X | 1 | Sarcoma, Metastatic, Skin | | 1 | Sarcoma, Metastatic, Skeletal Muscle | X | 1 | |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + | 58 | Sarcoma | X | 1 | |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + M + | 58 | Histiocytic Sarcoma | | 1 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + | 58 | Squamous Cell Papilloma | | 2 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + | 57 | Sarcoma | X | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | | 1 | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + | 59 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + M + | 58 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + M + | 58 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + | 60 | |__________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + | 57 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 49 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 __________________________________________________________________________________________________________________________________ | 7| 7| 5| 7| 7| 7| 7| 7| 6| 6| | | DAY ON TEST | 3| 3| 5| 3| 3| 3| 3| 3| 7| 7| | | | 2| 2| 3| 2| 2| 5| 5| 5| 2| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A | 2500 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | | | | Pituitary Gland | + + + + + + + + + + | 53 | Pars Distalis, Adenoma | X | 3 | Pars Intermedia, Adenoma | | 1 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + | 58 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | |__________________________________________________________________________|____________| Tissue NOS | | 3 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + | 57 | |__________________________________________________________________________|____________| Ovary | + M + + + + + + + + | 56 | Cystadenoma | X | 2 | Luteoma | | 1 | Teratoma Malignant | | 1 | |__________________________________________________________________________|____________| Uterus | + + + + + + + + + + | 60 | Histiocytic Sarcoma | | 1 | Leiomyosarcoma | X | 1 | Endometrium, Carcinoma | | 1 | Endometrium, Polyp Stromal | X | 2 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + | 60 | Histiocytic Sarcoma | | 1 | |__________________________________________________________________________|____________| Lymph Node | + + + | 10 | Lymphoma Malignant | | 1 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 50 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 __________________________________________________________________________________________________________________________________ | 7| 7| 5| 7| 7| 7| 7| 7| 6| 6| | | DAY ON TEST | 3| 3| 5| 3| 3| 3| 3| 3| 7| 7| | | | 2| 2| 3| 2| 2| 5| 5| 5| 2| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A | 2500 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | | | | Iliac, Lymphoma Malignant | | 2 | Inguinal, Lymphoma Malignant | | 2 | Inguinal, Sarcoma, Metastatic, Skin | | 1 | Mediastinal, Lymphoma Malignant | | 2 | Pancreatic, Lymphoma Malignant | | 3 | Pancreatic, Sarcoma | X | 1 | Renal, Lymphoma Malignant | | 2 | Renal, Sarcoma, Metastatic, Skin | | 1 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + M + | 55 | Histiocytic Sarcoma | | 1 | Lymphoma Malignant | | 3 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + | 57 | Histiocytic Sarcoma | | 1 | Lymphoma Malignant | X | 3 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 58 | Histiocytic Sarcoma | | 1 | Lymphoma Malignant | | 3 | |__________________________________________________________________________|____________| Thymus | + + M + + + + + + + | 55 | Lymphoma Malignant | | 1 | Thymoma Malignant | | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + | 60 | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + | 60 | Subcutaneous Tissue, Hemangiosarcoma | | 2 | Subcutaneous Tissue, Sarcoma | | 5 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 51 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 __________________________________________________________________________________________________________________________________ | 7| 7| 5| 7| 7| 7| 7| 7| 6| 6| | | DAY ON TEST | 3| 3| 5| 3| 3| 3| 3| 3| 7| 7| | | | 2| 2| 3| 2| 2| 5| 5| 5| 2| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A | 2500 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| INTEGUMENTARY SYSTEM - cont | | | | | | Subcutaneous Tissue, Sarcoma, | | | Multiple | X | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + | 60 | Femur, Osteosarcoma | | 1 | |__________________________________________________________________________|____________| Skeletal Muscle | + + | 3 | Sarcoma | X | 2 | Sarcoma, Multiple | X | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + | 59 | |__________________________________________________________________________|____________| Peripheral Nerve | + | 2 | |__________________________________________________________________________|____________| Spinal Cord | + | 2 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + | 59 | Alveolar/Bronchiolar Adenoma | X | 4 | Histiocytic Sarcoma | | 1 | Osteosarcoma, Metastatic, Bone | | 1 | Sarcoma, Metastatic, Skeletal Muscle | X | 1 | Teratoma Malignant, Metastatic, Ovary| | 1 | Mediastinum, Histiocytic Sarcoma | | 1 | Mediastinum, Sarcoma, Metastatic, | | | Uncertain Primary Site | X | 1 | Mediastinum, Sarcoma, Metastatic, | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 52 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 __________________________________________________________________________________________________________________________________ | 7| 7| 5| 7| 7| 7| 7| 7| 6| 6| | | DAY ON TEST | 3| 3| 5| 3| 3| 3| 3| 3| 7| 7| | | | 2| 2| 3| 2| 2| 5| 5| 5| 2| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A | 2500 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| RESPIRATORY SYSTEM - cont | | | | | | Skeletal Muscle | X | 1 | |__________________________________________________________________________|____________| Nose | + + + + + + + + + + | 59 | |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + | 59 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Harderian Gland | + + + | 4 | Adenoma | X | 1 | Carcinoma | X X | 3 | |__________________________________________________________________________|____________| Lacrimal Gland | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 58 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + | 57 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + | 60 | Histiocytic Sarcoma | | 1 | Lymphoma Malignant | X | 5 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 53 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 _____________________________________________________________________________________________________________________ | 6| 6| 5| 6| 5| 4| 5| 5| 5| 5| 4| 6| 6| 5| 6| 5| 7| 6| 6| 6| 4| 7| 6| 5| 6| DAY ON TEST | 0| 5| 8| 4| 8| 8| 9| 8| 6| 7| 0| 7| 3| 8| 6| 0| 2| 4| 0| 9| 4| 0| 1| 2| 8| | 9| 9| 1| 0| 8| 8| 0| 3| 7| 5| 3| 1| 0| 3| 8| 7| 5| 7| 8| 6| 4| 2| 0| 2| 8| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5000 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + M + + + + +| |__________________________________________________________________________| Gallbladder | + A A A + A + + + A + A A + A A + A A M + A + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + A + + + + + A + + A + + A + + A A + A + + +| Hemangiosarcoma, Metastatic, | | Mesentery | X | |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + A + + + + + A + + A A + A + + +| |__________________________________________________________________________| Intestine Large, Cecum | + A + A + A + + + A + A A + A A + A A A + A + + +| Carcinoma | | |__________________________________________________________________________| Intestine Small, Duodenum | + A + A + + + + + A + + A + A A + A A A + A + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + A + A + A + + + A + + A + A A + A A A + A + + +| Carcinoma | | |__________________________________________________________________________| Intestine Small, Ileum | + A + A + A + + + A + + A + A A + A A A + A + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Cholangioma | | Hemangiosarcoma, Metastatic, Skin | X | Hepatocellular Carcinoma | X X X X X | Hepatocellular Carcinoma, Multiple | X X X X X| Hepatocellular Adenoma | X X X X X | Hepatocellular Adenoma, Multiple | X X X | Hepatocholangiocarcinoma | | Lymphoma Malignant | X | |__________________________________________________________________________| Mesentery | + + + + + + + + + + + + + + | Hemangiosarcoma | X X X X X X X X X X | Hemangiosarcoma, Multiple | X X | Sarcoma | X | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 54 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 _____________________________________________________________________________________________________________________ | 6| 6| 5| 6| 5| 4| 5| 5| 5| 5| 4| 6| 6| 5| 6| 5| 7| 6| 6| 6| 4| 7| 6| 5| 6| DAY ON TEST | 0| 5| 8| 4| 8| 8| 9| 8| 6| 7| 0| 7| 3| 8| 6| 0| 2| 4| 0| 9| 4| 0| 1| 2| 8| | 9| 9| 1| 0| 8| 8| 0| 3| 7| 5| 3| 1| 0| 3| 8| 7| 5| 7| 8| 6| 4| 2| 0| 2| 8| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5000 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Hemangiosarcoma, Metastatic, | | Mesentery | X | Sarcoma, Metastatic, Mesentery | X | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + M + + + + M M M + + + + +| |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Squamous Cell Papilloma | X| |__________________________________________________________________________| Stomach, Glandular | + + + + + A + + + + + + + + + A + + + A + + + + +| |__________________________________________________________________________| Tooth | + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + M + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + M + + + + + M M + + + + +| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + M + + + + + + + + + + + M +| |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + M M + + + + +| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | |__________________________________________________________________________| Tissue NOS | + + | __________________________________________|__________________________________________________________________________| Page 55 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 _____________________________________________________________________________________________________________________ | 6| 6| 5| 6| 5| 4| 5| 5| 5| 5| 4| 6| 6| 5| 6| 5| 7| 6| 6| 6| 4| 7| 6| 5| 6| DAY ON TEST | 0| 5| 8| 4| 8| 8| 9| 8| 6| 7| 0| 7| 3| 8| 6| 0| 2| 4| 0| 9| 4| 0| 1| 2| 8| | 9| 9| 1| 0| 8| 8| 0| 3| 7| 5| 3| 1| 0| 3| 8| 7| 5| 7| 8| 6| 4| 2| 0| 2| 8| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5000 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| GENERAL BODY SYSTEM - cont | | | | Abdominal, Hemangiosarcoma | X | Abdominal, Hemangiosarcoma, Multiple | X | Thoracic, Sarcoma | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + I + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Ovary | + + M + + + + + + + + + + + + + + + + + + + + + +| Luteoma | | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | Cervix, Hemangiosarcoma | X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lymph Node | + + + + + | Iliac, Sarcoma, Metastatic, Skin | | Inguinal, Lymphoma Malignant | X | Mediastinal, Sarcoma, Metastatic, | | Uncertain Primary Site | X | Renal, Hemangiosarcoma, Metastatic, | | Mesentery | X | Renal, Lymphoma Malignant | | Renal, Sarcoma, Metastatic, Skin | | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + M + + M M + + + M M A + + + + +| Lymphoma Malignant | X | |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | Sarcoma, Metastatic, Mesentery | X | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 56 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 _____________________________________________________________________________________________________________________ | 6| 6| 5| 6| 5| 4| 5| 5| 5| 5| 4| 6| 6| 5| 6| 5| 7| 6| 6| 6| 4| 7| 6| 5| 6| DAY ON TEST | 0| 5| 8| 4| 8| 8| 9| 8| 6| 7| 0| 7| 3| 8| 6| 0| 2| 4| 0| 9| 4| 0| 1| 2| 8| | 9| 9| 1| 0| 8| 8| 0| 3| 7| 5| 3| 1| 0| 3| 8| 7| 5| 7| 8| 6| 4| 2| 0| 2| 8| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5000 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | |__________________________________________________________________________| Thymus | + + M M M + + + + + + + + + + M + M M M + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Basal Cell Carcinoma | | Subcutaneous Tissue, Hemangiosarcoma | X X X X X X| Subcutaneous Tissue, Hemangiosarcoma,| | Multiple | X | Subcutaneous Tissue, Sarcoma | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Skeletal Muscle | + + + + + + + + +| Hemangiosarcoma | X X X X X X X| Hemangiosarcoma, Multiple | X | Sarcoma | | Sarcoma, Multiple | X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Peripheral Nerve | + | |__________________________________________________________________________| Spinal Cord | + | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 57 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 _____________________________________________________________________________________________________________________ | 6| 6| 5| 6| 5| 4| 5| 5| 5| 5| 4| 6| 6| 5| 6| 5| 7| 6| 6| 6| 4| 7| 6| 5| 6| DAY ON TEST | 0| 5| 8| 4| 8| 8| 9| 8| 6| 7| 0| 7| 3| 8| 6| 0| 2| 4| 0| 9| 4| 0| 1| 2| 8| | 9| 9| 1| 0| 8| 8| 0| 3| 7| 5| 3| 1| 0| 3| 8| 7| 5| 7| 8| 6| 4| 2| 0| 2| 8| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5000 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Lung | + + + + + + + + + + + + + + + + + M + M + + + + +| Alveolar/Bronchiolar Adenoma | X | Alveolar/Bronchiolar Carcinoma, | | Multiple | X | Carcinoma, Metastatic, Harderian | | Gland | | Hemangiosarcoma, Metastatic, Skin | X | Hemangiosarcoma, Metastatic, | | Uncertain Primary Site | | Hemangiosarcoma, Metastatic, | | Skeletal Muscle | X X | Hepatocellular Carcinoma, Metastatic,| | Liver | | Sarcoma, Metastatic, Mesentery | | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + M + + + + + +| |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + M M + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Harderian Gland | + | Adenoma | X | Carcinoma | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | |__________________________________________________________________________| Urinary Bladder | + + + + I A + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | __________________________________________|__________________________________________________________________________| Page 58 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 _____________________________________________________________________________________________________________________ | 7| 6| 6| 6| 4| 6| 5| 6| 6| 5| 6| 6| 6| 7| 7| 5| 7| 6| 5| 5| 6| 4| 6| 6| 6| DAY ON TEST | 2| 7| 6| 8| 4| 6| 9| 2| 7| 6| 5| 2| 6| 1| 1| 1| 2| 9| 4| 6| 9| 0| 7| 1| 8| | 9| 5| 1| 5| 4| 9| 7| 9| 9| 7| 8| 4| 1| 0| 0| 6| 2| 0| 8| 9| 3| 9| 7| 9| 6| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5000 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + M A + + + + + + + + + + + + + +| |__________________________________________________________________________| Gallbladder | + A + A + A A A + M A A A + + A A + + + + + A + M| |__________________________________________________________________________| Intestine Large, Colon | + A + A + + A A + A A + + + + + A + + + + + A + +| Hemangiosarcoma, Metastatic, | | Mesentery | | |__________________________________________________________________________| Intestine Large, Rectum | + + + A + + A A + A A + + + + + A + + + + + A + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + A + A A A + A A A A + + + A + A + + + A + +| Carcinoma | X X X | |__________________________________________________________________________| Intestine Small, Duodenum | + A + A + A A A + A A A + + + + A + A + + + A + +| |__________________________________________________________________________| Intestine Small, Jejunum | + A + A + A A A + A A A + + + + A + + + + + A + +| Carcinoma | X | |__________________________________________________________________________| Intestine Small, Ileum | + A + A + A A A A A A A + + + + A + + + + + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Cholangioma | X | Hemangiosarcoma, Metastatic, Skin | | Hepatocellular Carcinoma | X X | Hepatocellular Carcinoma, Multiple | X X | Hepatocellular Adenoma | X | Hepatocellular Adenoma, Multiple | X X X X X X X X X X X| Hepatocholangiocarcinoma | X | Lymphoma Malignant | | |__________________________________________________________________________| Mesentery | + + + + + + + + + + + | Hemangiosarcoma | X X X X X X X | Hemangiosarcoma, Multiple | X X X X | Sarcoma | | |__________________________________________________________________________| Pancreas | + + + + + + + + + A A + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 59 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 _____________________________________________________________________________________________________________________ | 7| 6| 6| 6| 4| 6| 5| 6| 6| 5| 6| 6| 6| 7| 7| 5| 7| 6| 5| 5| 6| 4| 6| 6| 6| DAY ON TEST | 2| 7| 6| 8| 4| 6| 9| 2| 7| 6| 5| 2| 6| 1| 1| 1| 2| 9| 4| 6| 9| 0| 7| 1| 8| | 9| 5| 1| 5| 4| 9| 7| 9| 9| 7| 8| 4| 1| 0| 0| 6| 2| 0| 8| 9| 3| 9| 7| 9| 6| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5000 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Hemangiosarcoma, Metastatic, | | Mesentery | | Sarcoma, Metastatic, Mesentery | | |__________________________________________________________________________| Salivary Glands | + + + + + M M M + M M + + + + + + + + + + + M + +| |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Squamous Cell Papilloma | | |__________________________________________________________________________| Stomach, Glandular | + A + + + + + + + A A + + + + + + + + + + + A + +| |__________________________________________________________________________| Tooth | + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + | |__________________________________________________________________________| Heart | + + + + + + + + + + M + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Adrenal Medulla | + M + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + A A A + + + + + + + + + + + + +| |__________________________________________________________________________| Parathyroid Gland | + + + + + + M + M M M M + + + M + + + + + + + + +| |__________________________________________________________________________| Pituitary Gland | + + + + + + M + + M M + I + + + + + + + + + + + +| |__________________________________________________________________________| Thyroid Gland | + + + + + A + + + M M + + + + M + + + + + + + + +| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | |__________________________________________________________________________| Tissue NOS | + | __________________________________________|__________________________________________________________________________| Page 60 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 _____________________________________________________________________________________________________________________ | 7| 6| 6| 6| 4| 6| 5| 6| 6| 5| 6| 6| 6| 7| 7| 5| 7| 6| 5| 5| 6| 4| 6| 6| 6| DAY ON TEST | 2| 7| 6| 8| 4| 6| 9| 2| 7| 6| 5| 2| 6| 1| 1| 1| 2| 9| 4| 6| 9| 0| 7| 1| 8| | 9| 5| 1| 5| 4| 9| 7| 9| 9| 7| 8| 4| 1| 0| 0| 6| 2| 0| 8| 9| 3| 9| 7| 9| 6| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5000 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| GENERAL BODY SYSTEM - cont | | | | Abdominal, Hemangiosarcoma | | Abdominal, Hemangiosarcoma, Multiple | | Thoracic, Sarcoma | X | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + M + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Ovary | + + + + + + + M + + + + + + + + + + + + + + A + +| Luteoma | | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | Cervix, Hemangiosarcoma | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lymph Node | + + + + | Iliac, Sarcoma, Metastatic, Skin | X | Inguinal, Lymphoma Malignant | | Mediastinal, Sarcoma, Metastatic, | | Uncertain Primary Site | | Renal, Hemangiosarcoma, Metastatic, | | Mesentery | | Renal, Lymphoma Malignant | | Renal, Sarcoma, Metastatic, Skin | X | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + M M + + M M + + + + + + + + + + + M + +| Lymphoma Malignant | | |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + A M + + + + + + + + + + + + + +| Lymphoma Malignant | X | Sarcoma, Metastatic, Mesentery | | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 61 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 _____________________________________________________________________________________________________________________ | 7| 6| 6| 6| 4| 6| 5| 6| 6| 5| 6| 6| 6| 7| 7| 5| 7| 6| 5| 5| 6| 4| 6| 6| 6| DAY ON TEST | 2| 7| 6| 8| 4| 6| 9| 2| 7| 6| 5| 2| 6| 1| 1| 1| 2| 9| 4| 6| 9| 0| 7| 1| 8| | 9| 5| 1| 5| 4| 9| 7| 9| 9| 7| 8| 4| 1| 0| 0| 6| 2| 0| 8| 9| 3| 9| 7| 9| 6| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5000 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Spleen | + + + + + + + + + A + + + + + + + + + + + + M + +| Lymphoma Malignant | | |__________________________________________________________________________| Thymus | + + + M + + I + + A M + + + + I I + + + + + M + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + A + + + + + + + + + + + + + + +| |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Basal Cell Carcinoma | | Subcutaneous Tissue, Hemangiosarcoma | X X X X X X X X | Subcutaneous Tissue, Hemangiosarcoma,| | Multiple | X | Subcutaneous Tissue, Sarcoma | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Skeletal Muscle | + + + + + + + + +| Hemangiosarcoma | X X X X X X X| Hemangiosarcoma, Multiple | X | Sarcoma | X | Sarcoma, Multiple | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + M M + + + + + + + + + + + + + +| |__________________________________________________________________________| Peripheral Nerve | + + | |__________________________________________________________________________| Spinal Cord | + + | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 62 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 _____________________________________________________________________________________________________________________ | 7| 6| 6| 6| 4| 6| 5| 6| 6| 5| 6| 6| 6| 7| 7| 5| 7| 6| 5| 5| 6| 4| 6| 6| 6| DAY ON TEST | 2| 7| 6| 8| 4| 6| 9| 2| 7| 6| 5| 2| 6| 1| 1| 1| 2| 9| 4| 6| 9| 0| 7| 1| 8| | 9| 5| 1| 5| 4| 9| 7| 9| 9| 7| 8| 4| 1| 0| 0| 6| 2| 0| 8| 9| 3| 9| 7| 9| 6| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5000 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Lung | + + + + + + + + + + M + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X X X | Alveolar/Bronchiolar Carcinoma, | | Multiple | X | Carcinoma, Metastatic, Harderian | | Gland | | Hemangiosarcoma, Metastatic, Skin | | Hemangiosarcoma, Metastatic, | | Uncertain Primary Site | X | Hemangiosarcoma, Metastatic, | | Skeletal Muscle | | Hepatocellular Carcinoma, Metastatic,| | Liver | X | Sarcoma, Metastatic, Mesentery | X | |__________________________________________________________________________| Nose | + + + + + + + + + M M + + + + + + + + + + + + + +| |__________________________________________________________________________| Trachea | + + + + + + + + + M M + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Harderian Gland | + | Adenoma | | Carcinoma | X | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | |__________________________________________________________________________| Urinary Bladder | + + + + + + + M + A + + + + + + + + + + + + M + +| Hemangiosarcoma | | __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | __________________________________________|__________________________________________________________________________| Page 63 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 __________________________________________________________________________________________________________________________________ | 6| 6| 7| 5| 7| 7| 7| 6| 6| 6| | | DAY ON TEST | 0| 8| 2| 7| 2| 2| 2| 4| 9| 1| | | | 5| 6| 9| 9| 9| 9| 9| 3| 0| 1| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A | 5000 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + | 57 | |__________________________________________________________________________|____________| Gallbladder | + A + A + + + A + + | 31 | |__________________________________________________________________________|____________| Intestine Large, Colon | + A + A + + + A + A | 41 | Hemangiosarcoma, Metastatic, | | | Mesentery | | 1 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + A + + + + + A + + | 46 | |__________________________________________________________________________|____________| Intestine Large, Cecum | A A + A + + + A + A | 32 | Carcinoma | | 3 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | A A + A + + + A + A | 34 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | A A + A + + + A + A | 34 | Carcinoma | | 1 | |__________________________________________________________________________|____________| Intestine Small, Ileum | A A + A + + + A + A | 34 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + | 60 | Cholangioma | | 1 | Hemangiosarcoma, Metastatic, Skin | | 1 | Hepatocellular Carcinoma | X X | 9 | Hepatocellular Carcinoma, Multiple | | 7 | Hepatocellular Adenoma | X X X | 9 | Hepatocellular Adenoma, Multiple | X X X X X X | 20 | Hepatocholangiocarcinoma | | 1 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Mesentery | + + + + + + + + + | 34 | Hemangiosarcoma | X X X X X X X X | 25 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 64 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 __________________________________________________________________________________________________________________________________ | 6| 6| 7| 5| 7| 7| 7| 6| 6| 6| | | DAY ON TEST | 0| 8| 2| 7| 2| 2| 2| 4| 9| 1| | | | 5| 6| 9| 9| 9| 9| 9| 3| 0| 1| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A | 5000 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | | | | Hemangiosarcoma, Multiple | X | 7 | Sarcoma | | 1 | |__________________________________________________________________________|____________| Pancreas | + M + + + + + + + + | 57 | Hemangiosarcoma, Metastatic, | | | Mesentery | | 1 | Sarcoma, Metastatic, Mesentery | | 1 | |__________________________________________________________________________|____________| Salivary Glands | + + + M + + + + + + | 49 | |__________________________________________________________________________|____________| Stomach, Forestomach | + A + + + + + + + + | 59 | Squamous Cell Papilloma | | 1 | |__________________________________________________________________________|____________| Stomach, Glandular | + A + + + + + + + + | 52 | |__________________________________________________________________________|____________| Tooth | | 2 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | | 1 | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + | 58 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + | 60 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + | 59 | |__________________________________________________________________________|____________| Islets, Pancreatic | + M + + + + + + + + | 56 | |__________________________________________________________________________|____________| Parathyroid Gland | + + + + + M + + + + | 50 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 65 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 __________________________________________________________________________________________________________________________________ | 6| 6| 7| 5| 7| 7| 7| 6| 6| 6| | | DAY ON TEST | 0| 8| 2| 7| 2| 2| 2| 4| 9| 1| | | | 5| 6| 9| 9| 9| 9| 9| 3| 0| 1| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A | 5000 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + M | 53 | |__________________________________________________________________________|____________| Thyroid Gland | + + + M + + + + + + | 53 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | |__________________________________________________________________________|____________| Tissue NOS | | 3 | Abdominal, Hemangiosarcoma | | 1 | Abdominal, Hemangiosarcoma, Multiple | | 1 | Thoracic, Sarcoma | | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + | 58 | |__________________________________________________________________________|____________| Ovary | + M + + + + + + + + | 56 | Luteoma | X | 1 | |__________________________________________________________________________|____________| Uterus | + A + + + + + + + + | 59 | Hemangiosarcoma | | 2 | Cervix, Hemangiosarcoma | | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + | 60 | |__________________________________________________________________________|____________| Lymph Node | + + | 11 | Iliac, Sarcoma, Metastatic, Skin | | 1 | Inguinal, Lymphoma Malignant | X | 2 | Mediastinal, Sarcoma, Metastatic, | | | Uncertain Primary Site | | 1 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 66 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 __________________________________________________________________________________________________________________________________ | 6| 6| 7| 5| 7| 7| 7| 6| 6| 6| | | DAY ON TEST | 0| 8| 2| 7| 2| 2| 2| 4| 9| 1| | | | 5| 6| 9| 9| 9| 9| 9| 3| 0| 1| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A | 5000 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | | | | Renal, Hemangiosarcoma, Metastatic, | | | Mesentery | | 1 | Renal, Lymphoma Malignant | X | 1 | Renal, Sarcoma, Metastatic, Skin | | 1 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + M + + + + + + | 48 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + A + + + + + + + + | 57 | Lymphoma Malignant | X | 3 | Sarcoma, Metastatic, Mesentery | | 1 | |__________________________________________________________________________|____________| Spleen | + A + + + + + + + + | 57 | Lymphoma Malignant | X | 2 | |__________________________________________________________________________|____________| Thymus | I + + M + + + + + + | 44 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + | 59 | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + | 60 | Basal Cell Carcinoma | X | 1 | Subcutaneous Tissue, Hemangiosarcoma | X X | 16 | Subcutaneous Tissue, Hemangiosarcoma,| | | Multiple | X | 3 | Subcutaneous Tissue, Sarcoma | | 2 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + | 60 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 67 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 __________________________________________________________________________________________________________________________________ | 6| 6| 7| 5| 7| 7| 7| 6| 6| 6| | | DAY ON TEST | 0| 8| 2| 7| 2| 2| 2| 4| 9| 1| | | | 5| 6| 9| 9| 9| 9| 9| 3| 0| 1| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A | 5000 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| MUSCULOSKELETAL SYSTEM - cont | | | | | | Skeletal Muscle | | 18 | Hemangiosarcoma | | 14 | Hemangiosarcoma, Multiple | | 2 | Sarcoma | | 1 | Sarcoma, Multiple | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + | 58 | |__________________________________________________________________________|____________| Peripheral Nerve | | 3 | |__________________________________________________________________________|____________| Spinal Cord | | 3 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + | 57 | Alveolar/Bronchiolar Adenoma | | 4 | Alveolar/Bronchiolar Carcinoma, | | | Multiple | | 2 | Carcinoma, Metastatic, Harderian | | | Gland | X | 1 | Hemangiosarcoma, Metastatic, Skin | | 1 | Hemangiosarcoma, Metastatic, | | | Uncertain Primary Site | | 1 | Hemangiosarcoma, Metastatic, | | | Skeletal Muscle | | 2 | Hepatocellular Carcinoma, Metastatic,| | | Liver | | 1 | Sarcoma, Metastatic, Mesentery | | 1 | |__________________________________________________________________________|____________| Nose | + + + + + + + + + + | 57 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 68 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 __________________________________________________________________________________________________________________________________ | 6| 6| 7| 5| 7| 7| 7| 6| 6| 6| | | DAY ON TEST | 0| 8| 2| 7| 2| 2| 2| 4| 9| 1| | | | 5| 6| 9| 9| 9| 9| 9| 3| 0| 1| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A | 5000 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| RESPIRATORY SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Trachea | + + + M + + + + + + | 55 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Harderian Gland | + + | 4 | Adenoma | X | 2 | Carcinoma | X | 2 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + A + + + + + + + + | 59 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Urinary Bladder | + A + + + + + + + + | 54 | Hemangiosarcoma | | 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + | 60 | Lymphoma Malignant | X | 3 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 69 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 2| 7| DAY ON TEST | 2| 3| 2| 2| 3| 3| 3| 2| 2| 3| 3| 3| 3| 3| 2| 2| 3| 1| 9| 3| 2| 2| 1| 6| 3| | 9| 1| 9| 9| 0| 0| 0| 9| 9| 0| 0| 0| 0| 0| 9| 9| 0| 8| 6| 0| 9| 9| 0| 3| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Gallbladder | + + + + + + + + + + + + + + + + + A + + + + A + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + A + + + + A + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + A + + + + A + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + A + + + + A + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + A A + + + A + +| Hemangiosarcoma | | |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + A + + + + A + +| Adenocarcinoma | | Carcinoma | | |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + A A + + + A + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | | Hepatoblastoma | | Hepatocellular Carcinoma | X X X X | Hepatocellular Carcinoma, Multiple | X X | Hepatocellular Adenoma | X X X X X X X| Hepatocellular Adenoma, Multiple | X X | Lymphoma Malignant | X | |__________________________________________________________________________| Mesentery | + + + + + + | Lymphoma Malignant | | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 70 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 2| 7| DAY ON TEST | 2| 3| 2| 2| 3| 3| 3| 2| 2| 3| 3| 3| 3| 3| 2| 2| 3| 1| 9| 3| 2| 2| 1| 6| 3| | 9| 1| 9| 9| 0| 0| 0| 9| 9| 0| 0| 0| 0| 0| 9| 9| 0| 8| 6| 0| 9| 9| 0| 3| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + A + + + + + + +| |__________________________________________________________________________| Tooth | + + + + + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | Capsule, Adenoma | X | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + M + + M M + + + +| |__________________________________________________________________________| Pituitary Gland | + + + M + + + + M + + + + + + + + + + + + + + I +| Pars Distalis, Adenoma | | |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Follicular Cell, Adenoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | |__________________________________________________________________________| Tissue NOS | + | Thoracic, Sarcoma | X | Thoracic, Sarcoma, Multiple | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 71 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 2| 7| DAY ON TEST | 2| 3| 2| 2| 3| 3| 3| 2| 2| 3| 3| 3| 3| 3| 2| 2| 3| 1| 9| 3| 2| 2| 1| 6| 3| | 9| 1| 9| 9| 0| 0| 0| 9| 9| 0| 0| 0| 0| 0| 9| 9| 0| 8| 6| 0| 9| 9| 0| 3| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM - cont | | | | Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | |__________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Mast Cell Tumor Malignant | | |__________________________________________________________________________| Lymph Node | + | Iliac, Lymphoma Malignant | | Mediastinal, Lymphoma Malignant | | Mediastinal, Sarcoma, Metastatic, | | Tissue NOS | X | Pancreatic, Lymphoma Malignant | | Renal, Lymphoma Malignant | | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + M +| Lymphoma Malignant | X | |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma, Metastatic, Spleen | X | Lymphoma Malignant | X | |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangioma | | Hemangiosarcoma | X X | Lymphoma Malignant | X | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 72 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 2| 7| DAY ON TEST | 2| 3| 2| 2| 3| 3| 3| 2| 2| 3| 3| 3| 3| 3| 2| 2| 3| 1| 9| 3| 2| 2| 1| 6| 3| | 9| 1| 9| 9| 0| 0| 0| 9| 9| 0| 0| 0| 0| 0| 9| 9| 0| 8| 6| 0| 9| 9| 0| 3| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Thymus | + + + + + + + + + + + + + + + + + M + + + + + + I| Lymphoma Malignant | X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M + M M| |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Skeletal Muscle | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Peripheral Nerve | + | |__________________________________________________________________________| Spinal Cord | + | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X X X | Alveolar/Bronchiolar Carcinoma | X X | Alveolar/Bronchiolar Carcinoma, | | Multiple | X | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | __________________________________________|__________________________________________________________________________| Page 73 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 2| 7| DAY ON TEST | 2| 3| 2| 2| 3| 3| 3| 2| 2| 3| 3| 3| 3| 3| 2| 2| 3| 1| 9| 3| 2| 2| 1| 6| 3| | 9| 1| 9| 9| 0| 0| 0| 9| 9| 0| 0| 0| 0| 0| 9| 9| 0| 8| 6| 0| 9| 9| 0| 3| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| SPECIAL SENSES SYSTEM - cont | | | | |__________________________________________________________________________| Ear | + | External Ear, Neural Crest Tumor, | | Malignant | X | |__________________________________________________________________________| Harderian Gland | + +| Adenoma | X| Carcinoma | X | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + A + + + + + + +| |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Lymphoma Malignant | X | __________________________________________|__________________________________________________________________________| Page 74 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 3| 2| 3| 2| 3| 3| 2| 3| 2| 3| 3| 2| 3| 3| 2| 3| 3| 4| 2| 2| 2| 3| 3| 2| 3| | 0| 9| 0| 9| 1| 7| 9| 0| 9| 0| 0| 9| 0| 0| 9| 0| 0| 9| 9| 9| 9| 0| 0| 9| 1| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Gallbladder | + + + + + M + + + + + + + + + + + M + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + A + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + A + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + A + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + A + + + + + + +| Hemangiosarcoma | X | |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + A + + + + + + +| Adenocarcinoma | X | Carcinoma | | |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + A + + + + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | Hepatoblastoma | | Hepatocellular Carcinoma | X X X | Hepatocellular Carcinoma, Multiple | X | Hepatocellular Adenoma | X X X X X X | Hepatocellular Adenoma, Multiple | X | Lymphoma Malignant | | |__________________________________________________________________________| Mesentery | + + + | Lymphoma Malignant | X | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + A + + + + + + +| Lymphoma Malignant | X | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 75 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 3| 2| 3| 2| 3| 3| 2| 3| 2| 3| 3| 2| 3| 3| 2| 3| 3| 4| 2| 2| 2| 3| 3| 2| 3| | 0| 9| 0| 9| 1| 7| 9| 0| 9| 0| 0| 9| 0| 0| 9| 0| 0| 9| 9| 9| 9| 0| 0| 9| 1| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + A + + + + + + +| |__________________________________________________________________________| Tooth | + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Capsule, Adenoma | | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + A + + + + + + +| |__________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + M + + M + + + + +| |__________________________________________________________________________| Pituitary Gland | + M + + + M + + + + + + M + + + + + + + + + + + +| Pars Distalis, Adenoma | X | |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Follicular Cell, Adenoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | |__________________________________________________________________________| Tissue NOS | + | Thoracic, Sarcoma | | Thoracic, Sarcoma, Multiple | X | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 76 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 3| 2| 3| 2| 3| 3| 2| 3| 2| 3| 3| 2| 3| 3| 2| 3| 3| 4| 2| 2| 2| 3| 3| 2| 3| | 0| 9| 0| 9| 1| 7| 9| 0| 9| 0| 0| 9| 0| 0| 9| 0| 0| 9| 9| 9| 9| 0| 0| 9| 1| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM - cont | | | | Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | |__________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Mast Cell Tumor Malignant | X | |__________________________________________________________________________| Lymph Node | + | Iliac, Lymphoma Malignant | X | Mediastinal, Lymphoma Malignant | X | Mediastinal, Sarcoma, Metastatic, | | Tissue NOS | | Pancreatic, Lymphoma Malignant | X | Renal, Lymphoma Malignant | X | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma, Metastatic, Spleen | | Lymphoma Malignant | X | |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangioma | X | Hemangiosarcoma | | Lymphoma Malignant | X X | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 77 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 3| 2| 3| 2| 3| 3| 2| 3| 2| 3| 3| 2| 3| 3| 2| 3| 3| 4| 2| 2| 2| 3| 3| 2| 3| | 0| 9| 0| 9| 1| 7| 9| 0| 9| 0| 0| 9| 0| 0| 9| 0| 0| 9| 9| 9| 9| 0| 0| 9| 1| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Thymus | + + + + + M + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Skeletal Muscle | + | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Peripheral Nerve | | |__________________________________________________________________________| Spinal Cord | + | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X X X X X| Alveolar/Bronchiolar Carcinoma | X | Alveolar/Bronchiolar Carcinoma, | | Multiple | X | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | __________________________________________|__________________________________________________________________________| Page 78 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 3| 2| 3| 2| 3| 3| 2| 3| 2| 3| 3| 2| 3| 3| 2| 3| 3| 4| 2| 2| 2| 3| 3| 2| 3| | 0| 9| 0| 9| 1| 7| 9| 0| 9| 0| 0| 9| 0| 0| 9| 0| 0| 9| 9| 9| 9| 0| 0| 9| 1| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| SPECIAL SENSES SYSTEM - cont | | | | |__________________________________________________________________________| Ear | | External Ear, Neural Crest Tumor, | | Malignant | | |__________________________________________________________________________| Harderian Gland | + + | Adenoma | X X | Carcinoma | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + A + + + + + + +| |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + A + + + + + + +| __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Lymphoma Malignant | X X | __________________________________________|__________________________________________________________________________| Page 79 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 __________________________________________________________________________________________________________________________________ | 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| | | DAY ON TEST | 3| 2| 9| 1| 3| 3| 2| 3| 3| 3| | | | 1| 9| 2| 9| 0| 0| 9| 0| 1| 0| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 0 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + | 60 | |__________________________________________________________________________|____________| Gallbladder | + + + A + + + I + + | 54 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + A + + + + + + | 56 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + A + + M + + + | 55 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + A + + + + + + | 56 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + A + + + + + + | 55 | Hemangiosarcoma | | 1 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + A + + + + + + | 56 | Adenocarcinoma | | 1 | Carcinoma | X | 1 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + A + + + + + + | 55 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + | 60 | Hemangiosarcoma | | 1 | Hepatoblastoma | X | 1 | Hepatocellular Carcinoma | X X | 9 | Hepatocellular Carcinoma, Multiple | | 3 | Hepatocellular Adenoma | X X | 15 | Hepatocellular Adenoma, Multiple | | 3 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Mesentery | + + + | 12 | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + | 59 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 80 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 __________________________________________________________________________________________________________________________________ | 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| | | DAY ON TEST | 3| 2| 9| 1| 3| 3| 2| 3| 3| 3| | | | 1| 9| 2| 9| 0| 0| 9| 0| 1| 0| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 0 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | | | | Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + | 60 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + | 60 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + A + + + + + + | 57 | |__________________________________________________________________________|____________| Tooth | + + + + + | 14 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + | 60 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + | 60 | Adenoma | | 1 | Capsule, Adenoma | | 1 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + | 60 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + | 59 | |__________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + | 55 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + M + + + + | 53 | Pars Distalis, Adenoma | | 1 | |__________________________________________________________________________|____________| Thyroid Gland | + + + A + + + + + + | 59 | Follicular Cell, Adenoma | | 1 | _____________________________________________________________________________________________________________________| | * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 81 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 __________________________________________________________________________________________________________________________________ | 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| | | DAY ON TEST | 3| 2| 9| 1| 3| 3| 2| 3| 3| 3| | | | 1| 9| 2| 9| 0| 0| 9| 0| 1| 0| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 0 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| GENERAL BODY SYSTEM | | | |__________________________________________________________________________|____________| Tissue NOS | | 2 | Thoracic, Sarcoma | | 1 | Thoracic, Sarcoma, Multiple | | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Epididymis | + + + + + + + + + + | 60 | |__________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + | 60 | Histiocytic Sarcoma | X | 1 | |__________________________________________________________________________|____________| Prostate | + + + + + + + + + + | 60 | |__________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + | 60 | |__________________________________________________________________________|____________| Testes | + + + + + + + + + + | 60 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + | 60 | Mast Cell Tumor Malignant | | 1 | |__________________________________________________________________________|____________| Lymph Node | + | 3 | Iliac, Lymphoma Malignant | | 1 | Mediastinal, Lymphoma Malignant | | 1 | Mediastinal, Sarcoma, Metastatic, | | | Tissue NOS | | 1 | Pancreatic, Lymphoma Malignant | | 1 | Renal, Lymphoma Malignant | | 1 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + | 59 | Lymphoma Malignant | | 1 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 82 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 __________________________________________________________________________________________________________________________________ | 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| | | DAY ON TEST | 3| 2| 9| 1| 3| 3| 2| 3| 3| 3| | | | 1| 9| 2| 9| 0| 0| 9| 0| 1| 0| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 0 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + | 60 | Hemangiosarcoma, Metastatic, Spleen | | 1 | Lymphoma Malignant | | 2 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 60 | Hemangioma | | 1 | Hemangiosarcoma | | 2 | Lymphoma Malignant | | 3 | |__________________________________________________________________________|____________| Thymus | + + + + + + + + + + | 57 | Lymphoma Malignant | | 2 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | M M M M M M M M M M | 1 | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + | 60 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + | 60 | |__________________________________________________________________________|____________| Skeletal Muscle | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + | 60 | |__________________________________________________________________________|____________| Peripheral Nerve | | 1 | |__________________________________________________________________________|____________| Spinal Cord | | 2 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 83 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 __________________________________________________________________________________________________________________________________ | 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| | | DAY ON TEST | 3| 2| 9| 1| 3| 3| 2| 3| 3| 3| | | | 1| 9| 2| 9| 0| 0| 9| 0| 1| 0| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 0 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + | 60 | Alveolar/Bronchiolar Adenoma | X | 9 | Alveolar/Bronchiolar Carcinoma | | 3 | Alveolar/Bronchiolar Carcinoma, | | | Multiple | | 2 | |__________________________________________________________________________|____________| Nose | + + + + + + + + + + | 60 | |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + | 60 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Ear | | 1 | External Ear, Neural Crest Tumor, | | | Malignant | | 1 | |__________________________________________________________________________|____________| Harderian Gland | + | 5 | Adenoma | X | 4 | Carcinoma | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 58 | |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + | 59 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + | 60 | Histiocytic Sarcoma | X | 1 | Lymphoma Malignant | | 3 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 84 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 _____________________________________________________________________________________________________________________ | 7| 7| 5| 7| 7| 5| 7| 6| 6| 6| 6| 7| 7| 7| 7| 5| 5| 7| 7| 4| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 4| 2| 3| 5| 2| 5| 3| 3| 4| 2| 1| 3| 3| 7| 4| 3| 3| 8| 2| 3| 2| 2| 2| | 0| 0| 2| 9| 0| 9| 8| 5| 0| 3| 1| 9| 0| 1| 0| 2| 5| 0| 0| 5| 9| 0| 9| 6| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1250 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Gallbladder | + + + + + A A A + A M + + + + A A + + + + + + A +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + A + M + A + + + + A M + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + A + M A + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + A + + + A A + A A + + + + A + + + + + + + A +| Carcinoma | X X X X X X | |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + A A A + A A + + + + + A + + + M + + A +| |__________________________________________________________________________| Intestine Small, Jejunum | + + A + + + A A A A A + + + + A A + + + + + + A +| |__________________________________________________________________________| Intestine Small, Ileum | + + + + + A A A A A A + + + M A A + + + M + + A +| Carcinoma | X | |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | | Hemangiosarcoma, Multiple | X X | Hepatoblastoma | X | Hepatocellular Carcinoma | X X X X X X X | Hepatocellular Carcinoma, Multiple | X X | Hepatocellular Adenoma | X X X X| Hepatocellular Adenoma, Multiple | X X X | Histiocytic Sarcoma | X | |__________________________________________________________________________| Mesentery | + + + + | Carcinoma, Metastatic, Intestine | | Large, Cecum | | Hemangiosarcoma | X X X | |__________________________________________________________________________| Oral Mucosa | | Pharyngeal, Squamous Cell Carcinoma | | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 85 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 _____________________________________________________________________________________________________________________ | 7| 7| 5| 7| 7| 5| 7| 6| 6| 6| 6| 7| 7| 7| 7| 5| 5| 7| 7| 4| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 4| 2| 3| 5| 2| 5| 3| 3| 4| 2| 1| 3| 3| 7| 4| 3| 3| 8| 2| 3| 2| 2| 2| | 0| 0| 2| 9| 0| 9| 8| 5| 0| 3| 1| 9| 0| 1| 0| 2| 5| 0| 0| 5| 9| 0| 9| 6| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1250 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Glandular | + + + + + + A A + + + + + + + A A + + + + + + A +| |__________________________________________________________________________| Tooth | + + + + + + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + M| |__________________________________________________________________________| Pituitary Gland | + + + + + + + M + I + + + M + + + + + M + + + + +| |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Carcinoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 86 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 _____________________________________________________________________________________________________________________ | 7| 7| 5| 7| 7| 5| 7| 6| 6| 6| 6| 7| 7| 7| 7| 5| 5| 7| 7| 4| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 4| 2| 3| 5| 2| 5| 3| 3| 4| 2| 1| 3| 3| 7| 4| 3| 3| 8| 2| 3| 2| 2| 2| | 0| 0| 2| 9| 0| 9| 8| 5| 0| 3| 1| 9| 0| 1| 0| 2| 5| 0| 0| 5| 9| 0| 9| 6| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1250 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM - cont | | | | |__________________________________________________________________________| Preputial Gland | + + M + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Prostate | + + + + + + + + + + + + I + + + + + + + + + + + +| |__________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Interstitial Cell, Adenoma | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | | |__________________________________________________________________________| Lymph Node | + | Pancreatic, Histiocytic Sarcoma | X | |__________________________________________________________________________| Lymph Node, Mandibular | + + M M + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lymph Node, Mesenteric | + + + M + + + + M + + + + + + + M + + + + + + + +| Carcinoma, Metastatic, Intestine | | Large, Cecum | | Histiocytic Sarcoma | X | |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | Histiocytic Sarcoma | X | |__________________________________________________________________________| Thymus | + + + + + + + M M + + + + + I + + + + + + + + M +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 87 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 _____________________________________________________________________________________________________________________ | 7| 7| 5| 7| 7| 5| 7| 6| 6| 6| 6| 7| 7| 7| 7| 5| 5| 7| 7| 4| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 4| 2| 3| 5| 2| 5| 3| 3| 4| 2| 1| 3| 3| 7| 4| 3| 3| 8| 2| 3| 2| 2| 2| | 0| 0| 2| 9| 0| 9| 8| 5| 0| 3| 1| 9| 0| 1| 0| 2| 5| 0| 0| 5| 9| 0| 9| 6| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1250 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | Sebaceous Gland, Carcinoma | X | Subcutaneous Tissue, Hemangioma | X | Subcutaneous Tissue, Hemangiosarcoma | X X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Cranium, Osteoma | | |__________________________________________________________________________| Skeletal Muscle | + + + + | Hemangiosarcoma | X X X X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X X | Alveolar/Bronchiolar Carcinoma | | Carcinoma, Metastatic, Intestine | | Large, Cecum | | Hemangiosarcoma, Metastatic, | | Uncertain Primary Site | X | Hepatocellular Carcinoma, Metastatic,| | Liver | X X | Histiocytic Sarcoma | X | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | | __________________________________________|__________________________________________________________________________| Page 88 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 _____________________________________________________________________________________________________________________ | 7| 7| 5| 7| 7| 5| 7| 6| 6| 6| 6| 7| 7| 7| 7| 5| 5| 7| 7| 4| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 4| 2| 3| 5| 2| 5| 3| 3| 4| 2| 1| 3| 3| 7| 4| 3| 3| 8| 2| 3| 2| 2| 2| | 0| 0| 2| 9| 0| 9| 8| 5| 0| 3| 1| 9| 0| 1| 0| 2| 5| 0| 0| 5| 9| 0| 9| 6| 9| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1250 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| SPECIAL SENSES SYSTEM - cont | | | | |__________________________________________________________________________| Harderian Gland | | Adenoma | | Carcinoma | | |__________________________________________________________________________| Zymbal's Gland | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | __________________________________________|__________________________________________________________________________| Page 89 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 _____________________________________________________________________________________________________________________ | 6| 4| 7| 7| 5| 6| 7| 7| 7| 7| 7| 6| 5| 7| 7| 5| 7| 4| 7| 6| 7| 7| 7| 7| 6| DAY ON TEST | 0| 6| 3| 1| 2| 4| 3| 3| 2| 3| 3| 9| 7| 3| 3| 9| 2| 6| 3| 8| 3| 2| 2| 2| 8| | 4| 9| 1| 7| 6| 1| 0| 0| 9| 0| 1| 0| 5| 0| 1| 2| 9| 0| 0| 8| 1| 9| 9| 9| 6| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1250 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Gallbladder | + A + + + A + + + + + + M + + + + A + A + + M + A| |__________________________________________________________________________| Intestine Large, Colon | + A + + A + + + + + + + A + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + A + + + + + + + + + + M + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + A + A A + + + + + + + + + + + + + + + + + + + A| Carcinoma | X X X X | |__________________________________________________________________________| Intestine Small, Duodenum | + A + + A + + + + + + + A + + + + A + + + + + + A| |__________________________________________________________________________| Intestine Small, Jejunum | + A + + A A + + + + + + A + + + + A + + + + + + A| |__________________________________________________________________________| Intestine Small, Ileum | + A + A A A + + + + + + A + + + + A + + + + + + A| Carcinoma | | |__________________________________________________________________________| Liver | + A + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X| Hemangiosarcoma, Multiple | X | Hepatoblastoma | | Hepatocellular Carcinoma | X | Hepatocellular Carcinoma, Multiple | X X | Hepatocellular Adenoma | X X X X | Hepatocellular Adenoma, Multiple | X X | Histiocytic Sarcoma | | |__________________________________________________________________________| Mesentery | + + + + + + + | Carcinoma, Metastatic, Intestine | | Large, Cecum | X | Hemangiosarcoma | X X X X | |__________________________________________________________________________| Oral Mucosa | + | Pharyngeal, Squamous Cell Carcinoma | X | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 90 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 _____________________________________________________________________________________________________________________ | 6| 4| 7| 7| 5| 6| 7| 7| 7| 7| 7| 6| 5| 7| 7| 5| 7| 4| 7| 6| 7| 7| 7| 7| 6| DAY ON TEST | 0| 6| 3| 1| 2| 4| 3| 3| 2| 3| 3| 9| 7| 3| 3| 9| 2| 6| 3| 8| 3| 2| 2| 2| 8| | 4| 9| 1| 7| 6| 1| 0| 0| 9| 0| 1| 0| 5| 0| 1| 2| 9| 0| 0| 8| 1| 9| 9| 9| 6| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1250 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Pancreas | + A + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Glandular | + + + A + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Tooth | + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Islets, Pancreatic | + A + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Parathyroid Gland | + + + + + + M + + + + + + + M + + + + + + + M + +| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + M + + + + + + + M + M M + + + + +| |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Carcinoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 91 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 _____________________________________________________________________________________________________________________ | 6| 4| 7| 7| 5| 6| 7| 7| 7| 7| 7| 6| 5| 7| 7| 5| 7| 4| 7| 6| 7| 7| 7| 7| 6| DAY ON TEST | 0| 6| 3| 1| 2| 4| 3| 3| 2| 3| 3| 9| 7| 3| 3| 9| 2| 6| 3| 8| 3| 2| 2| 2| 8| | 4| 9| 1| 7| 6| 1| 0| 0| 9| 0| 1| 0| 5| 0| 1| 2| 9| 0| 0| 8| 1| 9| 9| 9| 6| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1250 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM - cont | | | | |__________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Interstitial Cell, Adenoma | X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | | |__________________________________________________________________________| Lymph Node | + + | Pancreatic, Histiocytic Sarcoma | | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + M + + + M + + + + + + + + + + + + +| |__________________________________________________________________________| Lymph Node, Mesenteric | + A + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Intestine | | Large, Cecum | X | Histiocytic Sarcoma | | |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X X | Histiocytic Sarcoma | | |__________________________________________________________________________| Thymus | + + + + + + + + M + + + + I + + + + + + + + I + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 92 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 _____________________________________________________________________________________________________________________ | 6| 4| 7| 7| 5| 6| 7| 7| 7| 7| 7| 6| 5| 7| 7| 5| 7| 4| 7| 6| 7| 7| 7| 7| 6| DAY ON TEST | 0| 6| 3| 1| 2| 4| 3| 3| 2| 3| 3| 9| 7| 3| 3| 9| 2| 6| 3| 8| 3| 2| 2| 2| 8| | 4| 9| 1| 7| 6| 1| 0| 0| 9| 0| 1| 0| 5| 0| 1| 2| 9| 0| 0| 8| 1| 9| 9| 9| 6| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1250 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | Sebaceous Gland, Carcinoma | | Subcutaneous Tissue, Hemangioma | | Subcutaneous Tissue, Hemangiosarcoma | X X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Cranium, Osteoma | X | |__________________________________________________________________________| Skeletal Muscle | + +| Hemangiosarcoma | X X| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X X | Alveolar/Bronchiolar Carcinoma | X | Carcinoma, Metastatic, Intestine | | Large, Cecum | X | Hemangiosarcoma, Metastatic, | | Uncertain Primary Site | | Hepatocellular Carcinoma, Metastatic,| | Liver | | Histiocytic Sarcoma | | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | | __________________________________________|__________________________________________________________________________| Page 93 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 _____________________________________________________________________________________________________________________ | 6| 4| 7| 7| 5| 6| 7| 7| 7| 7| 7| 6| 5| 7| 7| 5| 7| 4| 7| 6| 7| 7| 7| 7| 6| DAY ON TEST | 0| 6| 3| 1| 2| 4| 3| 3| 2| 3| 3| 9| 7| 3| 3| 9| 2| 6| 3| 8| 3| 2| 2| 2| 8| | 4| 9| 1| 7| 6| 1| 0| 0| 9| 0| 1| 0| 5| 0| 1| 2| 9| 0| 0| 8| 1| 9| 9| 9| 6| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1250 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| SPECIAL SENSES SYSTEM - cont | | | | |__________________________________________________________________________| Harderian Gland | + + | Adenoma | | Carcinoma | X | |__________________________________________________________________________| Zymbal's Gland | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + A + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | __________________________________________|__________________________________________________________________________| Page 94 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 6| 7| 7| 7| 7| 4| 4| | | DAY ON TEST | 3| 2| 2| 9| 3| 3| 2| 2| 5| 6| | | | 1| 9| 9| 0| 0| 0| 9| 9| 1| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 1250 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + | 60 | |__________________________________________________________________________|____________| Gallbladder | + + + A + + + + A A | 42 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + | 52 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + A + + + + + + | 54 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + | 49 | Carcinoma | X X | 12 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + A + + + + + A | 45 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + A + + + + + A | 43 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + A + + + + + A | 40 | Carcinoma | | 1 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + | 59 | Hemangiosarcoma | | 1 | Hemangiosarcoma, Multiple | | 3 | Hepatoblastoma | | 1 | Hepatocellular Carcinoma | X | 9 | Hepatocellular Carcinoma, Multiple | X X X | 7 | Hepatocellular Adenoma | X X X X | 12 | Hepatocellular Adenoma, Multiple | X | 6 | Histiocytic Sarcoma | | 1 | |__________________________________________________________________________|____________| Mesentery | + | 12 | Carcinoma, Metastatic, Intestine | | | Large, Cecum | | 1 | Hemangiosarcoma | X | 8 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 95 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 6| 7| 7| 7| 7| 4| 4| | | DAY ON TEST | 3| 2| 2| 9| 3| 3| 2| 2| 5| 6| | | | 1| 9| 9| 0| 0| 0| 9| 9| 1| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 1250 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Oral Mucosa | | 1 | Pharyngeal, Squamous Cell Carcinoma | | 1 | |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + | 59 | |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + | 60 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + | 60 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + | 54 | |__________________________________________________________________________|____________| Tooth | + | 9 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + | 60 | Hemangiosarcoma | | 2 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + | 60 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + | 60 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + | 59 | |__________________________________________________________________________|____________| Parathyroid Gland | + + + + M + + + + M | 54 | |__________________________________________________________________________|____________| Pituitary Gland | + + + M + M + + + + | 50 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + I + + + + + | 59 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 96 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 6| 7| 7| 7| 7| 4| 4| | | DAY ON TEST | 3| 2| 2| 9| 3| 3| 2| 2| 5| 6| | | | 1| 9| 9| 0| 0| 0| 9| 9| 1| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 1250 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | | | | C-Cell, Carcinoma | X | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Epididymis | + + + + + + + + + + | 60 | |__________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + | 59 | |__________________________________________________________________________|____________| Prostate | + + + + + + + + + + | 59 | |__________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + | 60 | |__________________________________________________________________________|____________| Testes | + + + + + + + + + + | 60 | Interstitial Cell, Adenoma | | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + | 60 | Hemangiosarcoma | X | 1 | |__________________________________________________________________________|____________| Lymph Node | + | 4 | Pancreatic, Histiocytic Sarcoma | | 1 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + M | 55 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | M + + + + + + + + + | 55 | Carcinoma, Metastatic, Intestine | | | Large, Cecum | | 1 | Histiocytic Sarcoma | | 1 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 97 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 6| 7| 7| 7| 7| 4| 4| | | DAY ON TEST | 3| 2| 2| 9| 3| 3| 2| 2| 5| 6| | | | 1| 9| 9| 0| 0| 0| 9| 9| 1| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 1250 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | | | | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 60 | Hemangiosarcoma | | 3 | Histiocytic Sarcoma | | 1 | |__________________________________________________________________________|____________| Thymus | + + + + + M + + + + | 52 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | M M M M M M M M M M | | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + | 60 | Sebaceous Gland, Carcinoma | | 1 | Subcutaneous Tissue, Hemangioma | | 1 | Subcutaneous Tissue, Hemangiosarcoma | | 4 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + | 60 | Cranium, Osteoma | | 1 | |__________________________________________________________________________|____________| Skeletal Muscle | | 6 | Hemangiosarcoma | | 6 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + | 60 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + | 60 | Alveolar/Bronchiolar Adenoma | X X | 6 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 98 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 6| 7| 7| 7| 7| 4| 4| | | DAY ON TEST | 3| 2| 2| 9| 3| 3| 2| 2| 5| 6| | | | 1| 9| 9| 0| 0| 0| 9| 9| 1| 3| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 1250 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| RESPIRATORY SYSTEM - cont | | | | | | Alveolar/Bronchiolar Carcinoma | | 1 | Carcinoma, Metastatic, Intestine | | | Large, Cecum | | 1 | Hemangiosarcoma, Metastatic, | | | Uncertain Primary Site | | 1 | Hepatocellular Carcinoma, Metastatic,| | | Liver | | 2 | Histiocytic Sarcoma | | 1 | |__________________________________________________________________________|____________| Nose | + + + + + + + + + + | 60 | |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + | 60 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | + | 1 | |__________________________________________________________________________|____________| Harderian Gland | + | 3 | Adenoma | X | 1 | Carcinoma | | 1 | |__________________________________________________________________________|____________| Zymbal's Gland | + + | 2 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 59 | Histiocytic Sarcoma | | 1 | |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + A | 59 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + | 60 | Histiocytic Sarcoma | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 99 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 _____________________________________________________________________________________________________________________ | 5| 5| 5| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| 5| 4| 5| 4| 4| 7| 5| 4| 5| DAY ON TEST | 9| 3| 7| 0| 5| 3| 1| 5| 6| 6| 5| 2| 6| 1| 5| 9| 6| 9| 9| 6| 6| 0| 3| 7| 3| | 6| 1| 2| 3| 6| 3| 7| 6| 4| 6| 4| 3| 9| 6| 7| 6| 0| 2| 0| 7| 6| 6| 9| 0| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2500 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Gallbladder | A A A + + A A + A + A A A A M + A + + A + A A + +| Lymphoma Malignant | | |__________________________________________________________________________| Intestine Large, Colon | A + + + + A + + + + A A + A + + + + + A + A + + A| Muscularis, Serosa, Hemangiosarcoma | X | |__________________________________________________________________________| Intestine Large, Rectum | A A + + + A + + + + A A + A + + + + + A + A + + A| |__________________________________________________________________________| Intestine Large, Cecum | A A A + + A A + + + + A + A + A + + + A + + A + A| Carcinoma | X X X X X | |__________________________________________________________________________| Intestine Small, Duodenum | A A A + + A + + + + A A + A + + + + + A + A A + +| Lymphoma Malignant | | |__________________________________________________________________________| Intestine Small, Jejunum | A + A + + A A + + + A A + A + + + + + A + A A + A| |__________________________________________________________________________| Intestine Small, Ileum | A A A + + A A + + + A A + A + + + + + A + A A + A| Lymphoma Malignant | | |__________________________________________________________________________| Liver | + + + + + + + + + + + + + A + + + + + + + + + + +| Hemangiosarcoma | | Hemangiosarcoma, Metastatic, | | Skeletal Muscle | | Hepatocellular Carcinoma | X X X | Hepatocellular Carcinoma, Multiple | X | Hepatocellular Adenoma | X | Hepatocellular Adenoma, Multiple | X | Lymphoma Malignant | | |__________________________________________________________________________| Mesentery | + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Intestine | | Large, Cecum | | Hemangiosarcoma | X X X X X X X X X X X X X X| Hemangiosarcoma, Multiple | X X X | __________________________________________|__________________________________________________________________________| Page 100 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 _____________________________________________________________________________________________________________________ | 5| 5| 5| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| 5| 4| 5| 4| 4| 7| 5| 4| 5| DAY ON TEST | 9| 3| 7| 0| 5| 3| 1| 5| 6| 6| 5| 2| 6| 1| 5| 9| 6| 9| 9| 6| 6| 0| 3| 7| 3| | 6| 1| 2| 3| 6| 3| 7| 6| 4| 6| 4| 3| 9| 6| 7| 6| 0| 2| 0| 7| 6| 6| 9| 0| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2500 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Hemangiosarcoma, Metastatic, | | Skeletal Muscle | | Lymphoma Malignant | | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | Acinus, Hemangiosarcoma | X | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | |__________________________________________________________________________| Stomach, Forestomach | I + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | |__________________________________________________________________________| Stomach, Glandular | + A + + + + + + + + + A + A + + + + + A + + + + +| Lymphoma Malignant | | |__________________________________________________________________________| Tooth | + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + M + +| Lymphoma Malignant | | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + M + + + + + + + + M + +| |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + M + +| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + M + + + + + + + + M M + + +| Lymphoma Malignant | | __________________________________________|__________________________________________________________________________| Page 101 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 _____________________________________________________________________________________________________________________ | 5| 5| 5| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| 5| 4| 5| 4| 4| 7| 5| 4| 5| DAY ON TEST | 9| 3| 7| 0| 5| 3| 1| 5| 6| 6| 5| 2| 6| 1| 5| 9| 6| 9| 9| 6| 6| 0| 3| 7| 3| | 6| 1| 2| 3| 6| 3| 7| 6| 4| 6| 4| 3| 9| 6| 7| 6| 0| 2| 0| 7| 6| 6| 9| 0| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2500 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | |__________________________________________________________________________| Tissue NOS | + | Pelvic, Hemangiosarcoma | X | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Coagulating Gland | + | Hemangiosarcoma | X | |__________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Prostate | + + + + + + + + + + + + M + + + + + + + + M + + +| Hemangiosarcoma | X X | Lymphoma Malignant | | |__________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | |__________________________________________________________________________| Lymph Node | + + + + | Bronchial, Lymphoma Malignant | | Iliac, Lymphoma Malignant | | Mediastinal, Hemangiosarcoma, | | Metastatic, Mesentery | X | Mediastinal, Lymphoma Malignant | | __________________________________________|__________________________________________________________________________| Page 102 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 _____________________________________________________________________________________________________________________ | 5| 5| 5| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| 5| 4| 5| 4| 4| 7| 5| 4| 5| DAY ON TEST | 9| 3| 7| 0| 5| 3| 1| 5| 6| 6| 5| 2| 6| 1| 5| 9| 6| 9| 9| 6| 6| 0| 3| 7| 3| | 6| 1| 2| 3| 6| 3| 7| 6| 4| 6| 4| 3| 9| 6| 7| 6| 0| 2| 0| 7| 6| 6| 9| 0| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2500 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Renal, Lymphoma Malignant | | |__________________________________________________________________________| Lymph Node, Mandibular | M + + + + + + + + + + M + A + + + + + + + + + + M| Hemangioma | | |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + M + + + + + + + + + + +| Carcinoma, Metastatic, Intestine | | Large, Cecum | X | Lymphoma Malignant | | |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | |__________________________________________________________________________| Thymus | + + + + + I + + + + + + M M + + I + M + + + + + +| Lymphoma Malignant | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Subcutaneous Tissue, Fibrosarcoma | | Subcutaneous Tissue, Hemangiosarcoma | X | Subcutaneous Tissue, Lymphoma | | Malignant | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Skeletal Muscle | + + + + + + + + + + + + +| Hemangiosarcoma | X X X X X X X X X X| Hemangiosarcoma, Multiple | X X | Lymphoma Malignant | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | __________________________________________|__________________________________________________________________________| Page 103 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 _____________________________________________________________________________________________________________________ | 5| 5| 5| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| 5| 4| 5| 4| 4| 7| 5| 4| 5| DAY ON TEST | 9| 3| 7| 0| 5| 3| 1| 5| 6| 6| 5| 2| 6| 1| 5| 9| 6| 9| 9| 6| 6| 0| 3| 7| 3| | 6| 1| 2| 3| 6| 3| 7| 6| 4| 6| 4| 3| 9| 6| 7| 6| 0| 2| 0| 7| 6| 6| 9| 0| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2500 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| NERVOUS SYSTEM - cont | | | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Meninges, Lymphoma Malignant | | |__________________________________________________________________________| Peripheral Nerve | + | |__________________________________________________________________________| Spinal Cord | + | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X | Alveolar/Bronchiolar Carcinoma | | Hemangiosarcoma, Metastatic, | | Mesentery | X X | Hemangiosarcoma, Metastatic, Skin | | Hemangiosarcoma, Metastatic, | | Uncertain Primary Site | | Hemangiosarcoma, Metastatic, | | Skeletal Muscle | | Hepatocellular Carcinoma, Metastatic,| | Liver | | Lymphoma Malignant | | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | |__________________________________________________________________________| Pleura | | |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + | |__________________________________________________________________________| Harderian Gland | | __________________________________________|__________________________________________________________________________| Page 104 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 _____________________________________________________________________________________________________________________ | 5| 5| 5| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| 5| 4| 5| 4| 4| 7| 5| 4| 5| DAY ON TEST | 9| 3| 7| 0| 5| 3| 1| 5| 6| 6| 5| 2| 6| 1| 5| 9| 6| 9| 9| 6| 6| 0| 3| 7| 3| | 6| 1| 2| 3| 6| 3| 7| 6| 4| 6| 4| 3| 9| 6| 7| 6| 0| 2| 0| 7| 6| 6| 9| 0| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2500 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| SPECIAL SENSES SYSTEM - cont | | | | Adenoma | | Carcinoma | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + A + + + + + + + + + + +| Hemangiosarcoma, Metastatic, | | Mesentery | | Lymphoma Malignant | | |__________________________________________________________________________| Urethra | | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | | Lymphoma Malignant | | __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | __________________________________________|__________________________________________________________________________| Page 105 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 _____________________________________________________________________________________________________________________ | 5| 5| 4| 4| 5| 4| 5| 5| 4| 5| 5| 2| 5| 5| 4| 5| 5| 4| 5| 5| 6| 5| 5| 4| 5| DAY ON TEST | 8| 6| 8| 2| 6| 1| 8| 2| 7| 2| 4| 7| 4| 4| 5| 2| 6| 9| 0| 6| 4| 6| 5| 5| 4| | 8| 6| 5| 3| 0| 9| 8| 0| 6| 6| 8| 0| 4| 0| 1| 2| 9| 2| 4| 3| 5| 9| 3| 1| 8| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2500 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Gallbladder | + M A + A + A A + + A A + A + + + + + A + A + + M| Lymphoma Malignant | | |__________________________________________________________________________| Intestine Large, Colon | + + A + + A + + + + + A + + + + + + + A + + + + +| Muscularis, Serosa, Hemangiosarcoma | | |__________________________________________________________________________| Intestine Large, Rectum | + + A + + A + + + + + + + + + + + + + A + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + A A A A A + A + + + + + A + + + + + A + A + + M| Carcinoma | X X X | |__________________________________________________________________________| Intestine Small, Duodenum | + A A + + + + A + + + A + A + + + + + A + A + + +| Lymphoma Malignant | | |__________________________________________________________________________| Intestine Small, Jejunum | + A A A A A + A + + + A + A + + + + + A + A + + +| |__________________________________________________________________________| Intestine Small, Ileum | + A A A A A + A + + + A + A + + + + + A + A + + +| Lymphoma Malignant | | |__________________________________________________________________________| Liver | + + + + + + + + + + + A + + + + + + + + + + + + +| Hemangiosarcoma | X | Hemangiosarcoma, Metastatic, | | Skeletal Muscle | | Hepatocellular Carcinoma | | Hepatocellular Carcinoma, Multiple | | Hepatocellular Adenoma | | Hepatocellular Adenoma, Multiple | | Lymphoma Malignant | | |__________________________________________________________________________| Mesentery | + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Intestine | | Large, Cecum | X | Hemangiosarcoma | X X X X X X X X X X X X| Hemangiosarcoma, Multiple | X X X X | __________________________________________|__________________________________________________________________________| Page 106 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 _____________________________________________________________________________________________________________________ | 5| 5| 4| 4| 5| 4| 5| 5| 4| 5| 5| 2| 5| 5| 4| 5| 5| 4| 5| 5| 6| 5| 5| 4| 5| DAY ON TEST | 8| 6| 8| 2| 6| 1| 8| 2| 7| 2| 4| 7| 4| 4| 5| 2| 6| 9| 0| 6| 4| 6| 5| 5| 4| | 8| 6| 5| 3| 0| 9| 8| 0| 6| 6| 8| 0| 4| 0| 1| 2| 9| 2| 4| 3| 5| 9| 3| 1| 8| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2500 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Hemangiosarcoma, Metastatic, | | Skeletal Muscle | | Lymphoma Malignant | | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | Acinus, Hemangiosarcoma | | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | |__________________________________________________________________________| Stomach, Glandular | + + A + + + + A + + + + + + + + + + + A + + + + +| Lymphoma Malignant | | |__________________________________________________________________________| Tooth | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Parathyroid Gland | + + + + + + M + + + + + + + + + + + + + + M + + +| |__________________________________________________________________________| Pituitary Gland | + + + + + I + M I + + M + + + + + + + + I + + + +| Lymphoma Malignant | | __________________________________________|__________________________________________________________________________| Page 107 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 _____________________________________________________________________________________________________________________ | 5| 5| 4| 4| 5| 4| 5| 5| 4| 5| 5| 2| 5| 5| 4| 5| 5| 4| 5| 5| 6| 5| 5| 4| 5| DAY ON TEST | 8| 6| 8| 2| 6| 1| 8| 2| 7| 2| 4| 7| 4| 4| 5| 2| 6| 9| 0| 6| 4| 6| 5| 5| 4| | 8| 6| 5| 3| 0| 9| 8| 0| 6| 6| 8| 0| 4| 0| 1| 2| 9| 2| 4| 3| 5| 9| 3| 1| 8| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2500 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | |__________________________________________________________________________| Thyroid Gland | + + + + M + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | |__________________________________________________________________________| Tissue NOS | + | Pelvic, Hemangiosarcoma | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Coagulating Gland | | Hemangiosarcoma | | |__________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + M + + +| |__________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | Lymphoma Malignant | | |__________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | |__________________________________________________________________________| Lymph Node | + | Bronchial, Lymphoma Malignant | | Iliac, Lymphoma Malignant | | Mediastinal, Hemangiosarcoma, | | Metastatic, Mesentery | | Mediastinal, Lymphoma Malignant | | __________________________________________|__________________________________________________________________________| Page 108 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 _____________________________________________________________________________________________________________________ | 5| 5| 4| 4| 5| 4| 5| 5| 4| 5| 5| 2| 5| 5| 4| 5| 5| 4| 5| 5| 6| 5| 5| 4| 5| DAY ON TEST | 8| 6| 8| 2| 6| 1| 8| 2| 7| 2| 4| 7| 4| 4| 5| 2| 6| 9| 0| 6| 4| 6| 5| 5| 4| | 8| 6| 5| 3| 0| 9| 8| 0| 6| 6| 8| 0| 4| 0| 1| 2| 9| 2| 4| 3| 5| 9| 3| 1| 8| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2500 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Renal, Lymphoma Malignant | | |__________________________________________________________________________| Lymph Node, Mandibular | + M M + + + + + + + + + + M + + + + + + + + + + M| Hemangioma | X | |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + M + M + + + + + M + + + + + +| Carcinoma, Metastatic, Intestine | | Large, Cecum | X X | Lymphoma Malignant | | |__________________________________________________________________________| Spleen | + + A + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | |__________________________________________________________________________| Thymus | + M + + + + + + I + + M M + + M + M I + + + I + +| Lymphoma Malignant | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Subcutaneous Tissue, Fibrosarcoma | X | Subcutaneous Tissue, Hemangiosarcoma | X X X X X X | Subcutaneous Tissue, Lymphoma | | Malignant | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Skeletal Muscle | + + + + + + + + + + + + + +| Hemangiosarcoma | X X X X X X X X X X | Hemangiosarcoma, Multiple | X X X X| Lymphoma Malignant | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | __________________________________________|__________________________________________________________________________| Page 109 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 _____________________________________________________________________________________________________________________ | 5| 5| 4| 4| 5| 4| 5| 5| 4| 5| 5| 2| 5| 5| 4| 5| 5| 4| 5| 5| 6| 5| 5| 4| 5| DAY ON TEST | 8| 6| 8| 2| 6| 1| 8| 2| 7| 2| 4| 7| 4| 4| 5| 2| 6| 9| 0| 6| 4| 6| 5| 5| 4| | 8| 6| 5| 3| 0| 9| 8| 0| 6| 6| 8| 0| 4| 0| 1| 2| 9| 2| 4| 3| 5| 9| 3| 1| 8| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2500 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| NERVOUS SYSTEM - cont | | | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Meninges, Lymphoma Malignant | | |__________________________________________________________________________| Peripheral Nerve | + | |__________________________________________________________________________| Spinal Cord | + | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | | Alveolar/Bronchiolar Carcinoma | X X | Hemangiosarcoma, Metastatic, | | Mesentery | X | Hemangiosarcoma, Metastatic, Skin | X X | Hemangiosarcoma, Metastatic, | | Uncertain Primary Site | X | Hemangiosarcoma, Metastatic, | | Skeletal Muscle | X | Hepatocellular Carcinoma, Metastatic,| | Liver | | Lymphoma Malignant | | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | |__________________________________________________________________________| Pleura | + | |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | | |__________________________________________________________________________| Harderian Gland | + + + | __________________________________________|__________________________________________________________________________| Page 110 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 _____________________________________________________________________________________________________________________ | 5| 5| 4| 4| 5| 4| 5| 5| 4| 5| 5| 2| 5| 5| 4| 5| 5| 4| 5| 5| 6| 5| 5| 4| 5| DAY ON TEST | 8| 6| 8| 2| 6| 1| 8| 2| 7| 2| 4| 7| 4| 4| 5| 2| 6| 9| 0| 6| 4| 6| 5| 5| 4| | 8| 6| 5| 3| 0| 9| 8| 0| 6| 6| 8| 0| 4| 0| 1| 2| 9| 2| 4| 3| 5| 9| 3| 1| 8| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2500 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| SPECIAL SENSES SYSTEM - cont | | | | Adenoma | X | Carcinoma | X | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + A + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma, Metastatic, | | Mesentery | X | Lymphoma Malignant | | |__________________________________________________________________________| Urethra | + | |__________________________________________________________________________| Urinary Bladder | + + M + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | Lymphoma Malignant | | __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant | | __________________________________________|__________________________________________________________________________| Page 111 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 __________________________________________________________________________________________________________________________________ | 4| 5| 5| 6| 4| 4| 3| 5| 6| 4| | | DAY ON TEST | 1| 9| 7| 2| 3| 9| 6| 6| 1| 6| | | | 0| 2| 2| 4| 4| 7| 5| 7| 9| 9| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 2500 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + | 60 | |__________________________________________________________________________|____________| Gallbladder | A + + + + + A + + A | 31 | Lymphoma Malignant | X | 1 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + A + + + + + + A | 46 | Muscularis, Serosa, Hemangiosarcoma | | 1 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + A + + + + + + A | 46 | |__________________________________________________________________________|____________| Intestine Large, Cecum | A + A + + + + + + A | 36 | Carcinoma | X | 9 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | A + A + + + + + + A | 40 | Lymphoma Malignant | X | 1 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | A + A + + + A + + A | 35 | |__________________________________________________________________________|____________| Intestine Small, Ileum | A + A + + + + + + A | 35 | Lymphoma Malignant | X | 1 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + A | 57 | Hemangiosarcoma | | 1 | Hemangiosarcoma, Metastatic, | | | Skeletal Muscle | X | 1 | Hepatocellular Carcinoma | X | 4 | Hepatocellular Carcinoma, Multiple | | 1 | Hepatocellular Adenoma | | 1 | Hepatocellular Adenoma, Multiple | X | 2 | Lymphoma Malignant | X | 1 | |__________________________________________________________________________|____________| Mesentery | + + + + + + + | 42 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 112 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 __________________________________________________________________________________________________________________________________ | 4| 5| 5| 6| 4| 4| 3| 5| 6| 4| | | DAY ON TEST | 1| 9| 7| 2| 3| 9| 6| 6| 1| 6| | | | 0| 2| 2| 4| 4| 7| 5| 7| 9| 9| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 2500 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | | | | Carcinoma, Metastatic, Intestine | | | Large, Cecum | | 1 | Hemangiosarcoma | X X X X | 30 | Hemangiosarcoma, Multiple | X | 8 | Hemangiosarcoma, Metastatic, | | | Skeletal Muscle | X | 1 | Lymphoma Malignant | X | 1 | |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + A | 59 | Lymphoma Malignant | X | 1 | Acinus, Hemangiosarcoma | | 1 | |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + | 60 | Lymphoma Malignant | X | 1 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + A | 58 | Lymphoma Malignant | X | 1 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + | 53 | Lymphoma Malignant | X | 1 | |__________________________________________________________________________|____________| Tooth | + | 2 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + | 60 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + A | 58 | Lymphoma Malignant | X | 1 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 113 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 __________________________________________________________________________________________________________________________________ | 4| 5| 5| 6| 4| 4| 3| 5| 6| 4| | | DAY ON TEST | 1| 9| 7| 2| 3| 9| 6| 6| 1| 6| | | | 0| 2| 2| 4| 4| 7| 5| 7| 9| 9| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 2500 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | | | | Adrenal Medulla | + + + + I + + + + A | 56 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + A | 59 | |__________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + | 57 | |__________________________________________________________________________|____________| Pituitary Gland | + + M M + + + + + + | 50 | Lymphoma Malignant | X | 1 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + | 59 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | |__________________________________________________________________________|____________| Tissue NOS | | 2 | Pelvic, Hemangiosarcoma | | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Coagulating Gland | + | 2 | Hemangiosarcoma | | 1 | |__________________________________________________________________________|____________| Epididymis | + + + + + + + + + + | 60 | |__________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + | 59 | |__________________________________________________________________________|____________| Prostate | + I + + + + + + + + | 57 | Hemangiosarcoma | X | 4 | Lymphoma Malignant | X | 1 | |__________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + | 60 | |__________________________________________________________________________|____________| Testes | + + + + + + + + + + | 60 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 114 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 __________________________________________________________________________________________________________________________________ | 4| 5| 5| 6| 4| 4| 3| 5| 6| 4| | | DAY ON TEST | 1| 9| 7| 2| 3| 9| 6| 6| 1| 6| | | | 0| 2| 2| 4| 4| 7| 5| 7| 9| 9| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 2500 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + | 60 | Lymphoma Malignant | X | 1 | |__________________________________________________________________________|____________| Lymph Node | + + | 7 | Bronchial, Lymphoma Malignant | X | 1 | Iliac, Lymphoma Malignant | X | 1 | Mediastinal, Hemangiosarcoma, | | | Metastatic, Mesentery | | 1 | Mediastinal, Lymphoma Malignant | X | 1 | Renal, Lymphoma Malignant | X | 1 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + M M + + + | 50 | Hemangioma | | 1 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + | 56 | Carcinoma, Metastatic, Intestine | | | Large, Cecum | | 3 | Lymphoma Malignant | X | 1 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + A | 58 | Lymphoma Malignant | X | 1 | |__________________________________________________________________________|____________| Thymus | + + I M + + + + + + | 45 | Lymphoma Malignant | X | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | M M M M M M M M M M | | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + | 60 | Subcutaneous Tissue, Fibrosarcoma | | 1 | Subcutaneous Tissue, Hemangiosarcoma | X | 8 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 115 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 __________________________________________________________________________________________________________________________________ | 4| 5| 5| 6| 4| 4| 3| 5| 6| 4| | | DAY ON TEST | 1| 9| 7| 2| 3| 9| 6| 6| 1| 6| | | | 0| 2| 2| 4| 4| 7| 5| 7| 9| 9| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 2500 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| INTEGUMENTARY SYSTEM - cont | | | | | | Subcutaneous Tissue, Lymphoma | | | Malignant | X | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + | 60 | |__________________________________________________________________________|____________| Skeletal Muscle | + + + + + + + + | 35 | Hemangiosarcoma | X X X X X | 25 | Hemangiosarcoma, Multiple | X X | 8 | Lymphoma Malignant | X | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + | 60 | Meninges, Lymphoma Malignant | X | 1 | |__________________________________________________________________________|____________| Peripheral Nerve | + | 3 | |__________________________________________________________________________|____________| Spinal Cord | + | 3 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + | 60 | Alveolar/Bronchiolar Adenoma | X X X | 4 | Alveolar/Bronchiolar Carcinoma | | 2 | Hemangiosarcoma, Metastatic, | | | Mesentery | | 3 | Hemangiosarcoma, Metastatic, Skin | X | 3 | Hemangiosarcoma, Metastatic, | | | Uncertain Primary Site | | 1 | Hemangiosarcoma, Metastatic, | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 116 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 __________________________________________________________________________________________________________________________________ | 4| 5| 5| 6| 4| 4| 3| 5| 6| 4| | | DAY ON TEST | 1| 9| 7| 2| 3| 9| 6| 6| 1| 6| | | | 0| 2| 2| 4| 4| 7| 5| 7| 9| 9| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 2500 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| RESPIRATORY SYSTEM - cont | | | | | | Skeletal Muscle | X | 2 | Hepatocellular Carcinoma, Metastatic,| | | Liver | X | 1 | Lymphoma Malignant | X | 1 | |__________________________________________________________________________|____________| Nose | + + + + + + + + + + | 60 | Lymphoma Malignant | X | 1 | |__________________________________________________________________________|____________| Pleura | | 1 | |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + | 60 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Eye | | 1 | |__________________________________________________________________________|____________| Harderian Gland | | 3 | Adenoma | | 1 | Carcinoma | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 58 | Hemangiosarcoma, Metastatic, | | | Mesentery | | 1 | Lymphoma Malignant | X | 1 | |__________________________________________________________________________|____________| Urethra | | 1 | |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + | 59 | Hemangiosarcoma | | 1 | Lymphoma Malignant | X | 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + | 60 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 117 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 __________________________________________________________________________________________________________________________________ | 4| 5| 5| 6| 4| 4| 3| 5| 6| 4| | | DAY ON TEST | 1| 9| 7| 2| 3| 9| 6| 6| 1| 6| | | | 0| 2| 2| 4| 4| 7| 5| 7| 9| 9| | | _____________________________________________________________________________________________________________________ T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 2500 PPM | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS - cont | | | | | | Lymphoma Malignant | X | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 118 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 _____________________________________________________________________________________________________________________ | 3| 3| 3| 4| 3| 3| 4| 3| 4| 2| 4| 4| 3| 3| 4| 3| 4| 3| 3| 3| 2| 3| 3| 3| 3| DAY ON TEST | 9| 9| 7| 0| 8| 7| 1| 7| 0| 7| 2| 4| 6| 7| 1| 9| 0| 9| 6| 9| 9| 9| 7| 9| 6| | 4| 6| 1| 3| 6| 6| 4| 5| 8| 7| 0| 9| 5| 5| 4| 2| 9| 2| 8| 4| 5| 1| 4| 3| 8| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 5000 PPM | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Gallbladder | A A + + M A A + A + + + + + + + + + + A + + A I +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + A + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + A + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | A + + + + + A + A + + + + + + + + + + A A + A + +| |__________________________________________________________________________| Intestine Small, Duodenum | A + + + A A A + A + + + + + + + + + + A A + A + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + A A A + A + + + + + + + + + + A A + A + +| |__________________________________________________________________________| Intestine Small, Ileum | A + + + A A A + A + + A + + + + + + + + A + A + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Carcinoma | X | |__________________________________________________________________________| Mesentery | + + + + + + + + + + + + + + + +| Hemangiosarcoma | X X X X X X X X | Hemangiosarcoma, Multiple | X X X X X X X X| |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Squamous Cell Papilloma | | |__________________________________________________________________________| Stomach, Glandular | A + + + + + + + + + + + + + + + + + + + A + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 119 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 _____________________________________________________________________________________________________________________ | 3| 3| 3| 4| 3| 3| 4| 3| 4| 2| 4| 4| 3| 3| 4| 3| 4| 3| 3| 3| 2| 3| 3| 3| 3| DAY ON TEST | 9| 9| 7| 0| 8| 7| 1| 7| 0| 7| 2| 4| 6| 7| 1| 9| 0| 9| 6| 9| 9| 9| 7| 9| 6| | 4| 6| 1| 3| 6| 6| 4| 5| 8| 7| 0| 9| 5| 5| 4| 2| 9| 2| 8| 4| 5| 1| 4| 3| 8| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 5000 PPM | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | Hemangiosarcoma | X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Parathyroid Gland | + + + + I + + + + + + + + + + + + + + M + + + + +| |__________________________________________________________________________| Pituitary Gland | + + + + + I I + + + + M + + + + + + M M + + I + +| |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | |__________________________________________________________________________| Tissue NOS | + +| Hemangiosarcoma | | Pelvic, Hemangiosarcoma | X | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Coagulating Gland | + | |__________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + M + + +| Hemangiosarcoma, Metastatic, | | Mesentery | | |__________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 120 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 _____________________________________________________________________________________________________________________ | 3| 3| 3| 4| 3| 3| 4| 3| 4| 2| 4| 4| 3| 3| 4| 3| 4| 3| 3| 3| 2| 3| 3| 3| 3| DAY ON TEST | 9| 9| 7| 0| 8| 7| 1| 7| 0| 7| 2| 4| 6| 7| 1| 9| 0| 9| 6| 9| 9| 9| 7| 9| 6| | 4| 6| 1| 3| 6| 6| 4| 5| 8| 7| 0| 9| 5| 5| 4| 2| 9| 2| 8| 4| 5| 1| 4| 3| 8| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 5000 PPM | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM - cont | | | | Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lymph Node | + | Inguinal, Hemangiosarcoma, | | Metastatic, Skeletal Muscle | X | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + M + + + + + + + + + + + M| |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + M + + + + + + + + + + + + + + M + + + +| |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Thymus | + + + + + + + + + + + M + + M + + + + + + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Subcutaneous Tissue, Hemangiosarcoma | X X X| Subcutaneous Tissue, Hemangiosarcoma,| | Multiple | X X X X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X X X X X X X X X X| Hemangiosarcoma, Multiple | X X X X X X X X X X X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | __________________________________________|__________________________________________________________________________| Page 121 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 _____________________________________________________________________________________________________________________ | 3| 3| 3| 4| 3| 3| 4| 3| 4| 2| 4| 4| 3| 3| 4| 3| 4| 3| 3| 3| 2| 3| 3| 3| 3| DAY ON TEST | 9| 9| 7| 0| 8| 7| 1| 7| 0| 7| 2| 4| 6| 7| 1| 9| 0| 9| 6| 9| 9| 9| 7| 9| 6| | 4| 6| 1| 3| 6| 6| 4| 5| 8| 7| 0| 9| 5| 5| 4| 2| 9| 2| 8| 4| 5| 1| 4| 3| 8| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 5000 PPM | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| NERVOUS SYSTEM - cont | | | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Peripheral Nerve | + + + + + +| |__________________________________________________________________________| Spinal Cord | + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma, Metastatic, | | Mesentery | X | Hemangiosarcoma, Metastatic, Skin | X | Hemangiosarcoma, Metastatic, | | Uncertain Primary Site | X | Hemangiosarcoma, Metastatic, | | Skeletal Muscle | X | Mediastinum, Hemangiosarcoma | X X X | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Lacrimal Gland | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Capsule, Hemangiosarcoma | X| |__________________________________________________________________________| Urethra | + +| |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 122 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 _____________________________________________________________________________________________________________________ | 4| 2| 4| 4| 4| 3| 4| 3| 3| 4| 4| 3| 3| 4| 3| 3| 3| 3| 3| 4| 4| 3| 4| 4| 4| DAY ON TEST | 4| 9| 0| 2| 5| 7| 0| 0| 9| 0| 1| 2| 6| 0| 8| 9| 7| 5| 5| 0| 0| 3| 1| 0| 0| | 0| 7| 6| 2| 0| 2| 3| 2| 2| 1| 4| 6| 8| 9| 0| 1| 5| 0| 8| 8| 6| 9| 4| 8| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 5000 PPM | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Gallbladder | A A + + A + + + + M + + + + A A + A M + + + + A A| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + A + + + + + + + A + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + A + + + + + + + A + + + + + + A| |__________________________________________________________________________| Intestine Large, Cecum | A + + + A + + + + A + + + + A + + A + + + + + A A| |__________________________________________________________________________| Intestine Small, Duodenum | A A + + + + + + A A + + + + + A + A + + + + + A +| |__________________________________________________________________________| Intestine Small, Jejunum | A + + + + + + + A A + + + + A A + A + + + + + A A| |__________________________________________________________________________| Intestine Small, Ileum | A + + + A + + + A A + + + + + A + A + + + M + A A| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Carcinoma | X | |__________________________________________________________________________| Mesentery | + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X X X X X X X X X X X X| Hemangiosarcoma, Multiple | X X X X X | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + A + + + + + + + + A| Hemangiosarcoma | X | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Squamous Cell Papilloma | X | |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + A + + + + + + A + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 123 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 _____________________________________________________________________________________________________________________ | 4| 2| 4| 4| 4| 3| 4| 3| 3| 4| 4| 3| 3| 4| 3| 3| 3| 3| 3| 4| 4| 3| 4| 4| 4| DAY ON TEST | 4| 9| 0| 2| 5| 7| 0| 0| 9| 0| 1| 2| 6| 0| 8| 9| 7| 5| 5| 0| 0| 3| 1| 0| 0| | 0| 7| 6| 2| 0| 2| 3| 2| 2| 1| 4| 6| 8| 9| 0| 1| 5| 0| 8| 8| 6| 9| 4| 8| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 5000 PPM | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | Hemangiosarcoma | X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + A| |__________________________________________________________________________| Parathyroid Gland | + M + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Pituitary Gland | + + + + M + + + I + + + + + + + + + I + I + + + M| |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | |__________________________________________________________________________| Tissue NOS | + | Hemangiosarcoma | X | Pelvic, Hemangiosarcoma | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Coagulating Gland | | |__________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + M + + +| Hemangiosarcoma, Metastatic, | | Mesentery | X | |__________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 124 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 _____________________________________________________________________________________________________________________ | 4| 2| 4| 4| 4| 3| 4| 3| 3| 4| 4| 3| 3| 4| 3| 3| 3| 3| 3| 4| 4| 3| 4| 4| 4| DAY ON TEST | 4| 9| 0| 2| 5| 7| 0| 0| 9| 0| 1| 2| 6| 0| 8| 9| 7| 5| 5| 0| 0| 3| 1| 0| 0| | 0| 7| 6| 2| 0| 2| 3| 2| 2| 1| 4| 6| 8| 9| 0| 1| 5| 0| 8| 8| 6| 9| 4| 8| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 5000 PPM | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM - cont | | | | Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lymph Node | | Inguinal, Hemangiosarcoma, | | Metastatic, Skeletal Muscle | | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + M + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + M + M + + + + + + + + + + + + + + + + + M| |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Thymus | + + + + M + + + + + + + + + + + + + I + + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Subcutaneous Tissue, Hemangiosarcoma | X X X X X X X X | Subcutaneous Tissue, Hemangiosarcoma,| | Multiple | X X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Skeletal Muscle | + + + + + + + + + + + + + + + + + | Hemangiosarcoma | X X X X X | Hemangiosarcoma, Multiple | X X X X X X X X X X X X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | __________________________________________|__________________________________________________________________________| Page 125 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 _____________________________________________________________________________________________________________________ | 4| 2| 4| 4| 4| 3| 4| 3| 3| 4| 4| 3| 3| 4| 3| 3| 3| 3| 3| 4| 4| 3| 4| 4| 4| DAY ON TEST | 4| 9| 0| 2| 5| 7| 0| 0| 9| 0| 1| 2| 6| 0| 8| 9| 7| 5| 5| 0| 0| 3| 1| 0| 0| | 0| 7| 6| 2| 0| 2| 3| 2| 2| 1| 4| 6| 8| 9| 0| 1| 5| 0| 8| 8| 6| 9| 4| 8| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 5000 PPM | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| __________________________________________|__________________________________________________________________________| NERVOUS SYSTEM - cont | | | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Peripheral Nerve | + + + + + | |__________________________________________________________________________| Spinal Cord | + + + + + | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma, Metastatic, | | Mesentery | | Hemangiosarcoma, Metastatic, Skin | X X X | Hemangiosarcoma, Metastatic, | | Uncertain Primary Site | X | Hemangiosarcoma, Metastatic, | | Skeletal Muscle | X X X X | Mediastinum, Hemangiosarcoma | X | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Lacrimal Gland | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Capsule, Hemangiosarcoma | | |__________________________________________________________________________| Urethra | | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 126 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 __________________________________________________________________________________________________________________________________ | 3| 3| 3| 4| 3| 4| 3| 4| 4| 4| | | DAY ON TEST | 5| 6| 4| 0| 1| 2| 9| 6| 1| 2| | | | 4| 8| 5| 9| 2| 7| 1| 2| 2| 2| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A | 5000 PPM | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + | 60 | |__________________________________________________________________________|____________| Gallbladder | A M M + + + + M A M | 35 | |__________________________________________________________________________|____________| Intestine Large, Colon | A A + + + + + A + + | 54 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + A + + + + + A + + | 54 | |__________________________________________________________________________|____________| Intestine Large, Cecum | A A + + + + + A + + | 44 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | A A A + + + + + + + | 42 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | A A A + + + + A A + | 40 | |__________________________________________________________________________|____________| Intestine Small, Ileum | A A A + + + + A + + | 39 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + | 60 | Hepatocellular Carcinoma | | 2 | |__________________________________________________________________________|____________| Mesentery | + + + + + | 38 | Hemangiosarcoma | X X X X | 24 | Hemangiosarcoma, Multiple | X | 14 | |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + | 58 | Hemangiosarcoma | | 1 | |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + | 60 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + | 60 | Squamous Cell Papilloma | X | 2 | |__________________________________________________________________________|____________| Stomach, Glandular | + A + + + + + + + + | 55 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 127 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 __________________________________________________________________________________________________________________________________ | 3| 3| 3| 4| 3| 4| 3| 4| 4| 4| | | DAY ON TEST | 5| 6| 4| 0| 1| 2| 9| 6| 1| 2| | | | 4| 8| 5| 9| 2| 7| 1| 2| 2| 2| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A | 5000 PPM | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + | 60 | Hemangiosarcoma | | 2 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + | 60 | |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + | 60 | |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + | 59 | |__________________________________________________________________________|____________| Parathyroid Gland | + M + + + + + + + + | 56 | |__________________________________________________________________________|____________| Pituitary Gland | + M I + + + + + M + | 46 | |__________________________________________________________________________|____________| Thyroid Gland | + I + + + + + + + + | 59 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | |__________________________________________________________________________|____________| Tissue NOS | | 3 | Hemangiosarcoma | | 1 | Pelvic, Hemangiosarcoma | | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Coagulating Gland | | 1 | |__________________________________________________________________________|____________| Epididymis | + + + + + + + + + + | 60 | |__________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + | 60 | |__________________________________________________________________________|____________| Prostate | + + + + + + + + + + | 58 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 128 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 __________________________________________________________________________________________________________________________________ | 3| 3| 3| 4| 3| 4| 3| 4| 4| 4| | | DAY ON TEST | 5| 6| 4| 0| 1| 2| 9| 6| 1| 2| | | | 4| 8| 5| 9| 2| 7| 1| 2| 2| 2| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A | 5000 PPM | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM - cont | | | | | | Hemangiosarcoma, Metastatic, | | | Mesentery | | 1 | |__________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + | 60 | |__________________________________________________________________________|____________| Testes | + + + + + + + + + + | 60 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + | 60 | |__________________________________________________________________________|____________| Lymph Node | | 1 | Inguinal, Hemangiosarcoma, | | | Metastatic, Skeletal Muscle | | 1 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + M M + + + + M + + | 54 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + M + + + + M + + | 53 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 60 | |__________________________________________________________________________|____________| Thymus | + + + + + + M I + + | 54 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | M M M M M M M M M M | | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + | 60 | Subcutaneous Tissue, Hemangiosarcoma | X | 12 | Subcutaneous Tissue, Hemangiosarcoma,| | | Multiple | X X | 8 | _____________________________________________________________________________________________________________________| | * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 129 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 __________________________________________________________________________________________________________________________________ | 3| 3| 3| 4| 3| 4| 3| 4| 4| 4| | | DAY ON TEST | 5| 6| 4| 0| 1| 2| 9| 6| 1| 2| | | | 4| 8| 5| 9| 2| 7| 1| 2| 2| 2| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A | 5000 PPM | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + | 60 | |__________________________________________________________________________|____________| Skeletal Muscle | + + + + + + + | 47 | Hemangiosarcoma | X X X X | 19 | Hemangiosarcoma, Multiple | X X X | 26 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + | 60 | |__________________________________________________________________________|____________| Peripheral Nerve | + | 12 | |__________________________________________________________________________|____________| Spinal Cord | + | 12 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + | 60 | Hemangiosarcoma, Metastatic, | | | Mesentery | | 1 | Hemangiosarcoma, Metastatic, Skin | | 4 | Hemangiosarcoma, Metastatic, | | | Uncertain Primary Site | | 2 | Hemangiosarcoma, Metastatic, | | | Skeletal Muscle | X X X | 8 | Mediastinum, Hemangiosarcoma | | 4 | |__________________________________________________________________________|____________| Nose | + + + + + + + + + + | 60 | |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + | 60 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 130 NTP Experiment-Test: 05203-09 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC O-NITROTOLUENE Date: 11/16/00 Route: DOSED FEED Time: 10:02:26 __________________________________________________________________________________________________________________________________ | 3| 3| 3| 4| 3| 4| 3| 4| 4| 4| | | DAY ON TEST | 5| 6| 4| 0| 1| 2| 9| 6| 1| 2| | | | 4| 8| 5| 9| 2| 7| 1| 2| 2| 2| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A | 5000 PPM | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| SPECIAL SENSES SYSTEM - cont | | | | | | Lacrimal Gland | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 60 | Capsule, Hemangiosarcoma | | 1 | |__________________________________________________________________________|____________| Urethra | | 2 | |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + | 60 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + | 60 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 131 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------