National Heart, Lung, and Blood Institute (NHLBI)
2007 Weinstein Cardiovascular Development Conference
May 10–12, 2007 • Indianapolis, IN
Agenda
| Thursday, May 10 |
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| 10:00 a.m. | Registration |
| 1:45 p.m. | Opening Remarks |
| 2:00 p.m. | Platform Session I |
| Cardiomyocyte Cell Cycle Regulation Chairs: Loren Field, Indiana University and Youngsook Lee, University of Wisconsin Medical School |
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| Chair’s Introduction | |
| 2:05 p.m. |
Cardiomyocyte and Epicardial Cell Addition During Cardiac Homeostasis in Adult Zebrafish Airon A. Wills Jennifer Holdway Robert J. Major Kenneth D. Poss Duke University Medical Center, Department of Cell Biology |
| 2:20 p.m. | FOXO Transcription Factors in the Regulation of Cardiac Myocyte Proliferation and Myocardial Growth during Development Heather J. Evans-Anderson Christina M. Alfieri Katherine E. Yutzey Division of Molecular Cardiovascular Biology, Cincinnati Children’s Hospital Medical Center |
| 2:35 p.m. | 3D Visualization of Proliferation in Cardiac and Extracardiac Mesoderm G. van den Berg A. T. Soufan P. A. J. de Boer M. J. B. van den Hoff A. F. M. Moorman Heart Failure Research Centre, Amsterdam, The Netherlands |
| 2:50 p.m. | Canonical Wnt Signaling is Required for Mammalian Cardiogenesis by Regulating Cardiac Progenitors Chulan Kwon Joshua Arnold Makoto Taketo Deepak Srivastava Gladstone Institute, University of California, San Francisco |
| 3:20 p.m. | Platform Session II |
| Myofibrogenesis Chairs: Lei Wei, Indiana University and Jeffrey Robbins, Cincinnati Children’s Hospital Medical Center |
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Chair’s Introduction |
| 3:25 p.m. | MEF2A Controls a Costameric Network of Genes in Cardiac Muscle Frank J. Naya Ondra M. Brand Joseph G. Reynolds Sarah A. McCalmon Department of Biology, Program in Cell and Molecular Biology, Boston University |
| 3:40 p.m. | Investigating the Role of Prox1 in the Developing Heart Catherine A. Risebro, UCL Institute of Child Health, London, England Richelle G. Searles, UCL Institute of Child Health, London, England Athalie A. D. Melville, UCL Institute of Child Health, London, England Paul R. Riley, UCL Institute of Child Health, London, England Elisabeth Ehler, The Randall Centre of Cell and Molecular Biophysics, Guy's Campus, Kings College, London, England Miriam Dillard, St. Jude Children's Research Hospital, Memphis Guillermo Oliver, St. Jude Children's Research Hospital, Memphis Natasha L. Harvey, The Hanson Institute, Adelaide, Australia Kelvin Moses, Texas A&M University Health Science Center, Houston Robert J. Schwartz, Texas A&M University Health Science Center, Houston Kenneth R. Chien, MGH Cardiovascular Research Center, Boston |
| 3:55 p.m. | High Resolution in vivo Imaging of the Cross-Sectional Deformations of Contracting Embryonic Heart Loops using Optical Coherence Tomography (OCT) Jorg Manner, Department of Anatomy and Embryology, Georg-August-University of Göttingen, Germany Lars Thrane, Optics and Plasma Research Department, Risø, Denmark Kambiz Norozi, Department of Pediatric Cardiology and Intensive Care Medicine, M.H.H. Hannover, Germany Mesud T. Yelbuz, Department of Pediatric Cardiology and Intensive Care Medicine, M.H.H. Hannover, Germany |
| 4:10 p.m. | Mouse Mutants with Defects in Cardiovascular Development Isolated from Balancer Chromosome Mutagenesis Screens Karen Mitchell, Faculty of Life Sciences, The University of Manchester, Manchester, England Michael D. Risley, Faculty of Life Sciences, The University of Manchester, Manchester, England David Green, Faculty of Life Sciences, The University of Manchester, Manchester, England Monica J. Justice, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas Kathryn E. Hentges, Faculty of Life Sciences, The University of Manchester, Manchester, England |
| 4:45 p.m. | Keynote Presentation 1 ES Cells: Back to the Future – The History and Promise of Embryonic Stem Cells Dr. Oliver Smithies |
| 6:00 p.m. | Poster Session 1 |
| 8:00 p.m. | Concurrent Workshops |
| Single versus Multiple Developmental Heart Fields Moderators: Anthony Firulli, Indiana University and Margaret Kirby, Duke University |
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| Cardiac Progenitor Populations Dr. Silvia Evans, University of California, San Diego |
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| Cardiomyogenic Stem Cells During Development Moderators: Loren Field, Indiana University; Paul Riley, University College London Institute of Child Health; and Dr. Steven Kattman, McEwen Centre for Regenerative Mecicine, Toronto |
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| 8:07 p.m. | The Right Ventricle, Outflow Tract, and Interventricular Septum are Derived from the Second Heart Field Dr. Brian Black, University of California, San Francisco |
| 8:12 p.m. | ES Cell Derived Cardiovascular Progenitor Cells Dr. Nicola Smart, UCL Institute of Child Health, London |
| 8:14 p.m. | Clonal Segregation Between the First and Second Myocardial Lineages Dr. Sigolène Meilhac, Institut Pasteur |
| 8:21 p.m. | The Caudal and Posterior Second Heart Field and the Origin of the
Left Ventricle in Chicken and Mouse Dr. Vincent Christoffels, University of Amsterdam |
| 8:24 p.m. | Epicardial Derived Vascular Progenitors Dr. Kaomei Guan, Georg-August-University of Goettingen |
| 8:28 p.m. | Panel Discussion |
| 8:36 p.m. | Spermatogonial-Derived ES-Like Cells Panel Discussion |
| Friday, May 11 |
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| 9:00 a.m. | Platform Session III |
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Transcription Factors in Cardiogenesis Chairs: Anthony Firulli, Indiana University and Brian Black, University of California, San Francisco |
| Chair’s Introduction | |
| 9:05 a.m. | Histone Deacetylase 1 (HDAC1) is Essential for Cardiac Development in Zebrafish Sigalit Zchut, Pediatric Cardiology, Department of Pediatrics, Rhode Island Hospital Providence, Rhode Island Lazaros Kochilas, Pediatric Cardiology, Department of Pediatrics, Rhode Island Hospital Providence, Rhode Island Kerri S. Warren, Department of Biology, Roger Williams University, Bristol, Rhode Island Robbert Creton, Department of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, Rhode Island |
| 9:20 a.m. | In Search for Partners of Tbx2 and Tbx3 Kees J. Boogerd L. Y. Elaine Wong M. Klarenbeek Vincent M. Christoffels Antoon F. M. Moorman Phil Barnett Heart Failure Research Centre, Academic Medical Centre, Amsterdam, The Netherlands |
| 9:35 a.m. | Cooperative Function of the Transcription Factors Nkx2.5 and Mef2c during Heart Development Joshua W. Vincentz Beth A. Firulli Anthony B. Firulli Department of Pediatrics, Wells Center for Pediatric Research, James Whitcomb Riley Hospital for Children, Indiana University School of Medicine Cancer Research Institute |
| 9:50 a.m. | Nkx Genes Regulate Heart Tube Extension in Zebrafish K. L. Targoff T. Schell D. Yelon Developmental Genetics Program and Department of Cell Biology, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York |
| 10:05 a.m. | DPF3 – A New Key Transcription Factor – Bridging Chromatin Remodeling and Cardiac Muscle Specification Martin Lange, Max Planck Institute for Molecular Genetics, Berlin, Germany Steffen Just, Ruprecht-Karls-University, Heidelberg, Germany Bogac Kaynak, Max Planck Institute for Molecular Genetics, Berlin, Germany Illona Dunkel, Max Planck Institute for Molecular Genetics, Berlin, Germany Jenny J. Fischer, Max Planck Institute for Molecular Genetics, Berlin, Germany Martje Toenjes, Max Planck Institute for Molecular Genetics, Berlin, Germany Tammo Krueger, Max Planck Institute for Molecular Genetics, Berlin, Germany Joern Toedling, European Bioinformatics Institute, European Molecular Biology Laboratory, Cambridge, United Kingdom Siegrun Mebus, German Heart Center, Berlin, Germany Christina Grimm, Max Planck Institute for Molecular Genetics, Berlin, Germany Wolfgang Rottbauer, Ruprecht-Karls-University, Heidelberg, Germany Silke Sperling, Max Planck Institute for Molecular Genetics, Berlin, Germany |
| 10:35 p.m. | Platform Session IV |
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Vascular Development Chairs: Michiko Watanabe, Case Western Reserve University and Pat Mastin, NIEHS, National Institutes of Health |
| Chair’s Introduction | |
| 10:40 a.m. | Connexin43 in the Epicardium is Required for Normal Coronary Development Xiao-Qing Zhao David Y. Rhee Cecilia W. Lo Laboratory of Developmental Biology, National Heart, Lung and Blood Institute, National Institutes of Health |
| 10:55 a.m. | Endothelial-Specific Ablation of Serum Response Factor Results in Vascular Instability and Embryonic Lethality Mary L. Holtz Ravi P. Misra Department of Biochemistry, Medical College of Wisconsin, Milwaukee, Wisconsin |
| 11:10 a.m. | VEGF-A164 Regulates Coronary Endothelial Proliferation, but not Tubulogenesis Richard L. Goodwin Tresa Nesbitt Michael J. Yost Jay D. Potts Department of Cell and Developmental Biology and Anatomy, University of South Carolina School of Medicine |
| 11:25 a.m. | Canonical Wnt Signaling in Endothelial Cells is Essential for Central Nervous System Vascularization and Blood-Brain Barrier Development Jan M. Stenman, Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts Thomas Carroll, Department of Internal Medicine (Nephrology) and Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas Jayaraj Rajagopal, Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts Andrew P. McMahon, Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts |
| 11:40 a.m. | Effect of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) on Hypoxia-Inducible Factor-1 Alpha during Chick Cardiogenesis Jamie Wikenheiser, Department of Pediatrics, Case Western Reserve University, Cleveland, Ohio Mary K. Walker, College of Pharmacy, University of New Mexico Health Sciences Center, Albuquerque, New Mexico Michiko Watanabe, Department of Pediatrics, Case Western Reserve University, Cleveland, Ohio |
| 11:55 a.m. | NIH Presentation Pat Mastin, NIEHS |
| 1:15 p.m. | Concurrent Workshops |
| Cardiac Neural Crest Moderators: Simon Conway, Indiana University and Anne Moon, University of Utah |
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| Cardiac Neural Crest and Interactions with Endothelium Dr. Jon Epstein, University of Pennsylvania |
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| 1:27 p.m. | Mouse Models of PTA that Implicate a Defect Specifically in AP Septation Dr. Henry Sucov, University of Southern California |
| 1:39 p.m. | Cardiac Neural Crest Ablation Inhibits Compaction and
Electrical Function of Conduction System Bundles Dr. Rob Gourdie, Medical University of South Carolina |
| 1:51 p.m. | Panel Discussion |
| 1:15 p.m. | Imaging Cardiovascular Development and Physiology Moderators: Michael Rubart, Indiana University and Igor R. Efimov, Washington University |
| Biophotonic Imaging of Embryonic Heart Dr. Igor R. Efimov, Washington University, St. Louis, Missouri |
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| 1:30 p.m. | Embryonic Murine Heart using a Genetically Encoded Calcium
Inhibitor
Dr. N. Yvonne Tallini, Cornell University, Ithaca, New York |
| 1:45 p.m. | Imaging Fluid Motions and Heart Function in Vertebrate Embryos Dr. Mary E. Dickinson, Baylor College of Medicine, Houston, Texas |
| 2:00 p.m. | Panel Discussion |
| 2:40 p.m. | Platform Session V |
| Cardiac Conduction System Development Chairs: Michael Rubart, Indiana University and Luis Polo-Parada, University of Missouri, Columbia |
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| Chair’s Introduction | |
| 2:45 p.m. | Molecular and Physiological Mechanisms Underlying Embryonic Cardiac Rhythmicity in Zebrafish J. Huang, Department of Molecular, Cell, and Developmental Biology, University of California, Los Angeles A. Langenbacher, Department of Molecular, Cell, and Developmental Biology, University of California, Los Angeles J. Goldhaber, Department of Physiology, University of California, Los Angeles O. Kown, Department of Chemistry and Biochemistry, University of California, Los Angeles J. N. Chen, Department of Molecular, Cell, and Developmental Biology, University of California, Los Angeles |
| 3:00 p.m. | Tbx3 Acts as a Genetic Switch for Heart Pacemaker Formation Willem M. H. Hoogaars, Department of Anatomy and Embryology, University of Amsterdam, The Netherlands Janynke F. Brons, Department of Anatomy and Embryology, University of Amsterdam, The Netherlands Angela Engel, Department of Physiology, Heart Failure Research Center, Academic Medical Center, University of Amsterdam, The Netherlands Arie O. Verkerk, Department of Physiology, Heart Failure Research Center, Academic Medical Center, University of Amsterdam, The Netherlands Frederik J. de Lange, Department of Anatomy and Embryology, University of Amsterdam, The Netherlands Martijn L. Bakker, Department of Anatomy and Embryology, University of Amsterdam, The Netherlands Danielle E. Clout, Department of Anatomy and Embryology, University of Amsterdam, The Netherlands Vincent Wakker, Department of Anatomy and Embryology, University of Amsterdam, The Netherlands Jan Hindrik Ravesloot, Department of Physiology, Heart Failure Research Center, Academic Medical Center, University of Amsterdam, The Netherlands E. Etienne Verheijck, Department of Physiology, Heart Failure Research Center, Academic Medical Center, University of Amsterdam, The Netherlands Antoon F. M. Moorman, Department of Anatomy and Embryology, University of Amsterdam, The Netherlands Vincent M. Christoffels, Department of Anatomy and Embryology, University of Amsterdam, The Netherlands |
| 3:15 p.m. | Genetic Analysis of Popdc1 and Popdc2 Function in Mouse and Zebrafish Heart Alexander Froese, Cell and Developmental Biology, University of Würzburg, Germany Jan Schlüter, Cell and Developmental Biology, University of Würzburg, Germany Christoph Waldeyer, Department of Cardiology and Angiology, University Hospital Münster, Germany Bettina Kirchmaier, Cell and Developmental Biology, University of Würzburg, Germany Stephanie Breher, Cell and Developmental Biology, University of Würzburg, Germany Sonja K. Liebig, Department of Cardiology and Angiology, University Hospital Münster, Germany Sandra Laakmann, Department of Cardiology and Angiology, University Hospital Münster, Germany Paulus Kirchhof, Department of Cardiology and Angiology, University Hospital Münster, Germany Joachim Neumann, Institute of Pharmacology, University of Halle, Germany Christoph Winkler, Chemistry I, Biocenter, University of Würzburg, Germany Franz Vauti, Cell and Molecular Biology, TU Braunschweig, Germany Arnold Hans-Henning, Cell and Molecular Biology, TU Braunschweig, Germany Larissa Fabritz, Department of Cardiology and Angiology, University Hospital Münster, Germany Thomas Brand, Cell and Developmental Biology, University of Würzburg, Germany |
| 3:30 p.m. | Clonal Analysis of the Origin of the Mammalian Ventricular Conduction System Lucile Miquerol Natividad Moreno Sigolene Meilhac Margaret Buckingham Diego Franco Robert G. Kelly Inserm Avenir group, Developmental Biology Institute of Marseilles–Luminy, Marseille, France |
| 3:45 p.m. | Deletion of the Cardiac L-Type Calcium Channel (CaV1.2) Causes Embryonic Death George A. Porter, Jr. Ashwani Sharma Yale University School of Medicine |
| 4:30 p.m. | Keynote Presentation 2 |
| How Many Heart Fields Does it Take to Make a Heart? Dr. Margaret Kirby |
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| 6:00 p.m. | Poster Session 2 |
| Saturday, May 12 | |
| 7:30 a.m. | Platform Session VI |
| 9:00 a.m. | Signaling Pathways in Cardiogenesis Chairs: Weinian Shou, Indiana University and Jim Martin, Texas A & M Health Science Center Institute of Biosciences and Technology |
| Chair’s Introduction | |
| 9:05 a.m. | Endocardial Brg1 Represses ADAMTS1 to Maintain the Microenvironment for Myocardial Morphogenesis Kryn Stankunas, Division of Cardiovascular Medicine, Stanford University School of Medicine Calvin T. Hang, Division of Cardiovascular Medicine, Stanford University School of Medicine Hanying Chen, Department of Pediatrics, Indiana University School of Medicine Zhi-Yang Tsun, Division of Cardiovascular Medicine, Stanford University School of Medicine Jiang Wu, Department of Pathology, Stanford University School of Medicine Ching Shang, Division of Cardiovascular Medicine, Stanford University School of Medicine J. Henri Bayle, Department of Pathology, Stanford University School of Medicine W. Shou, Department of Pediatrics, Indiana University School of Medicine Ching-Pin Chang, Division of Cardiovascular Medicine, Stanford University School of Medicine |
| 9:20 a.m. | Myocardial Smad4 Is Essential for Cardiogenesis in Mouse Embryos Song Lanying, Department of Genetics, Division of Genetic and Translational Medicine, The University of Alabama at Birmingham, Alabama Wensheng Yan, Department of Cell Biology, The University of Alabama at Birmingham, Alabama Xinbin Chen, Department of Cell Biology, The University of Alabama at Birmingham, Alabama Qin Wang, Department of Physiology and Biophysics, The University of Alabama at Birmingham, Alabama Kai Jiao, Department of Genetics, Division of Genetic and Translational Medicine, The University of Alabama at Birmingham, Alabama |
| 9:35 a.m. | Sonic Hedgehog Modulates Addition of the Secondary Heart Field to the Arterial Pole Laura A. Barbosky Margaret L. Kirby Department of Cell Biology, Duke University, Durham, North Carolina |
| 9:50 a.m. | BMP4 Function is Required in Second Heart Field-Derived Myocardium for Endocardial Cushion Remodeling, Outflow Tract Septation, and Semilunar Valve Development David J. McCulley, Cardiovascular Research Institute, University of California, San Francisco Ji-One Kang, Cardiovascular Research Institute, University of California, San Francisco Pooja Agarwal, Cardiovascular Research Institute, University of California, San Francisco Anabel Rojas, Cardiovascular Research Institute, University of California, San Francisco James F. Martin, Institute of Biosciences and Technology, Texas A&M Health Science Center, Houston, Texas Brian L. Black, Cardiovascular Research Institute and Department of Biochemistry and Biophysics, University of California, San Francisco |
| 10:05 a.m. | Retinoic Acid Deficiency Alters Secondary Heart Field Formation and NKx2.5 Regulation Lucile Ryckebusch, Developmental Biology Institute of Marseille-Luminy, France Song-Chang Lin, Baylor College of Medicine, Houston, Texas Zengxin Wang, Baylor College of Medicine, Houston, Texas Xuan Chi, The Institute of Biosciences and Technology, Houston, Texas Robert Schwartz, The Institute of Biosciences and Technology, Houston, Texas Margaret Buckingham, Institut Pasteur, Paris, France Stéphane Zaffran, Developmental Biology Institute of Marseille-Luminy, France Karen Niederreither, Baylor College of Medicine, Houston, Texas |
| 10:35 a.m. | Platform Session VII |
| Valvulogenesis Chairs: Katherine Yutzey, Cincinnati Children’s Medical Center and Andy Wessels, Medical University of South Carolina |
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| Chair’s Introduction | |
| 10:40 a.m. | Distinct Functions of the MAP3 Kinases, MEKK3 and MEKK4, for Heart Valve Development Mark V. Stevens, Department of Pharmacology and Toxicology, University of Arizona Elisa Rogowitz, Department of Molecular and Cellular Biology, University of Arizona Sofia Lalani, Department of Cell Biology and Anatomy, University of Arizona Patti Parker, Department of Pharmacology and Toxicology, University of Arizona Derrick Broka, Department of Pharmacology and Toxicology, University of Arizona Richard R. Vaillancourt, Department of Pharmacology and Toxicology, University of Arizona Todd D. Camenisch, Department of Pharmacology and Toxicology, University of Arizona and Sarver Heart Center, University of Arizona |
| 10:55 a.m. | Tbx20 and Twist1 Function in Endocardial Cushion Mesenchyme Elaine L. Shelton Katherine E. Yutzey Molecular and Developmental Biology Graduate Program, University of Cincinnati |
| 11:10 a.m. | TGF-Beta2 is Required in vivo for Epithelial-Mesenchymal
Transformation, Collagen Fibrollogenesis, and Differentiation,
Condensation, and Maturation of Mesenchyme during Valvulogenesis
Mohamad Azhar, BIO5 Institute and Department of Cell Biology and Anatomy, University of Arizona, Tucson, Arizona Moying Yin, Department of Molecular Genetics, University of Cincinnati College of Medicine, Cincinnati, Ohio Jennifer Martin, Department of Molecular Genetics, University of Cincinnati College of Medicine, Cincinnati, Ohio Sharon A. Pawloski, Department of Molecular Genetics, University of Cincinnati College of Medicine, Cincinnati, Ohio Vikram Prasad, Department of Molecular Genetics, University of Cincinnati College of Medicine, Cincinnati, Ohio Sudersan Rajan, Department of Molecular Genetics, University of Cincinnati College of Medicine, Cincinnati, Ohio Mariane Miller, Department of Molecular Genetics, University of Cincinnati College of Medicine, Cincinnati, Ohio Dora Chen, BIO5 Institute, University of Arizona, Tucson, Arizona Ray B. Runyan, Department of Anatomy and Embryology, Leiden University Medical Center, Leiden, The Netherlands Adriana C. Gittenberger-de Groot, Department of Anatomy and Embryology, Leiden University Medical Center, Leiden, The Netherlands Elaine Fuchs, Howard Hughes Medical Institute, The Rockefeller University, New York, New York Tom Doetschman, BIO5 Institute and Department of Cell Biology and Anatomy, University of Arizona, Tucson, Arizona |
| 11:25 a.m. | The Role of Cartilage Link Protein 1 (Crtl1) in Heart Development Elaine Wirrig Brian Snarr Aimee Phelps Jessica O'Neal Jeremy Barth Christine Kern Victor Fresco Corey Mjaatvedt Stanley Hoffman Thomas Trusk W. Scott Argraves Andy Wessels The Medical University of South Carolina; Department of Cell Biology and Anatomy |
| 11:40 a.m. | Endocardial Cells Transformation is Dependent on Par6 Regulation of
RhoA Todd A. Townsend, Department of Pharmacology, Vanderbilt University, Nashville, Tennesse Jeffrey L. Wrana, Department of Medical Genetics and Microbiology, University of Toronto, Toronto, Ontario, Canada George E. Davis, Department of Medical Pharmacology and Physiology, University of Missouri, Columbia, Missouri Joey V. Barnett, Department of Pharmacology, Vanderbilt University, Nashville, Tennesse |
| 11:55 a.m. | NIH Presentation Charlene Schramm, NHLBI |
| 1:30 p.m. | Business Meeting |
| NIH Workshop Charlene Schramm |
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| 2:45 p.m. | Platform Session VIII |
| Animal Models of Congenital Heart Disease Chairs: Simon Conway, Indiana University and Christopher Brown, Vanderbilt University |
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| Chair’s Introduction | |
| 2:50 p.m. | A New Mutant Series Provides Insights Into Sensitivity of Heart Development to Tbx1-mRNA Dosage Zhen Zhang Antonio Baldini Center for Molecular Development and Disease, Institute of Biosciences and Technology, Health Science Center, Texas A&M University System |
| 3:05 p.m. | Titration of Pax3 Expression Levels During Morphogenesis of the Outflow Tract Hongming Zhou Simon J. Conway Cardiovascular Development Group, Herman B. Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana |
| 3:20 p.m. | Polycomb Repressive Complex I Plays a Cell Autonomous Role in Cardiac Development Caroline Jenkins Erwin Boutsma Simon Bamforth Bradley Joyce Angela Franklyn Carol Broadbent Jurgen Schneider Robert Schwartz Yumiko Saga Haruhiko Koseki Maarten van Lohuizen Shoumo Bhattacharya University of Oxford, Cardiovascular Medicine, Wellcome Trust Centre For Human Genetics |
| 3:35 p.m. | Multiple Functions of EIIIA and EIIIB Splice Isoforms of Fibronectin in Cardiovascular development Sophie Astrof, Weill Medical School of Cornell University Richard Hynes, Massachusetts Institute of Technology |
| 3:50 p.m. | Loss of Fibulin-1 in Mice Causes a DiGeorge Syndrome-like Phenotype Marion A. Cooley Christine B. Kern Victor M. Fresco Andy Wessels Robert P. Thompson Tim C. McQuinn Waleed O. Twal Corey H. Mjaatvedt Christopher J. Drake W. Scott Argraves Cardiovascular Developmental Biology Center, Department of Cell Biology and Anatomy, Medical University of South Carolina, Charleston, South Carolina |
| 4:30 p.m. | Platform Session IX |
| Translational Models of Congenital Heart Disease Chairs: Mark Payne, Indiana University and Jamie Lohr, University of Minnesota |
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| Chair’s Introduction | |
| 4:35 p.m. | A Novel Murine Model with Features of Vacterl and Caudal Regression Indicates a Common Genetic Origin for both Syndromes Dorota Szumska, Department of Cardiovascular Medicine, University of Oxford, United Kingdom Guido Pieles, Department of Cardiovascular Medicine, University of Oxford, United Kingdom Michal Bilski, Department of Cardiovascular Medicine, University of Oxford, United Kingdom Angela Franklyn, Department of Cardiovascular Medicine, University of Oxford, United Kingdom Marie Cormack, Mammalian Genetics Unit, MRC Harwell, United Kingdom Juergen E. Schneider, Department of Cardiovascular Medicine, University of Oxford, United Kingdom Joanna Jefferis, Nuffield Department of Surgery, University of Oxford, United Kingdom Paul Johnson, Nuffield Department of Surgery, University of Oxford, United Kingdom Zuzanna Lalanne, Mammalian Genetics Unit, MRC Harwell, United Kingdom Stefan Neubauer, Department of Cardiovascular Medicine, University of Oxford, United Kingdom Kieran Clarke, Department of Physiology, University of Oxford, United Kingdom Steve D. Brown, Mammalian Genetics Unit, MRC Harwell, United Kingdom Shoumo Bhattacharya, Department of Cardiovascular Medicine, University of Oxford, United Kingdom |
| 4:50 p.m. | Mediating ERK1/2 Signaling Rescues Congenital Heart Defects in a Mouse Model of Noonan Syndrome Tomoki Nakamura Melissa C. Colbert Maike Krenz Jeffery D. Molkentin Jeffery Robbins Division of Molecular Cardiovascular Biology, Cincinnati Children's Hospital Medical Center |
| 5:05 p.m. | Muscleblind 2, an RNA Binding Protein Important in Myotonic Dystrophy and Cardiac Conduction Minqi Hao Kevan Akrami Ke Wei Thomas M. Vondriska James Tidball Michael Graves Perry B. Shieh Fabian Chen University of California, Los Angeles |
| 5:20 p.m. | Duplication of the Entire 22.9-Mb Human Chromosome 21 Syntenic Region on Mouse Chromosome 16 Causes Cardiovascular Abnormalities Zhongyou Li, Center for Genetics and Pharmacology, Roswell Park Cancer Institute Tao Yu, Center for Genetics and Pharmacology, Roswell Park Cancer Institute Masae Morishima, Department of Pediatric Cardiology and Nephrology, Kyoto Prefectural University of Medicine, Kyoto, Japan Annie Pao, Center for Genetics and Pharmacology, Roswell Park Cancer Institute Jeffrey LaDuca, Center for Genetics and Pharmacology, Roswell Park Cancer Institute Jeffrey Conroy, Center for Genetics and Pharmacology, Roswell Park Cancer Institute Norma Nowak, Center for Genetics and Pharmacology, Roswell Park Cancer Institute and New York State Center of Excellence in Bioinformatics and Life Sciences Sei-Ichi Matsui, Center for Genetics and Pharmacology, Roswell Park Cancer Institute Isao Shiraishi, Department of Pediatric Cardiology and Nephrology, Kyoto Prefectural University of Medicine, Kyoto, Japan Y. Eugene Yu, Center for Genetics and Pharmacology, Roswell Park Cancer Institute and New York State Center of Excellence in Bioinformatics and Life Sciences |
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