Bibliographic Citation
Document | For copies of Journal Articles, please contact the Publisher or your local public or university library and refer to the information in the Resource Relation field. For copies of other documents, please see the Availability, Publisher, Research Organization, Resource Relation and/or Author (affiliation information) fields and/or Document Availability. |
---|---|
Title | Radiotherapy as a cause of complete atrioventricular block in Hodgkin`s disease: an electrophysiological-pathological correlation |
Creator/Author | Cohen, S.I. ; Bharati, S. ; Glass, J. ; Lev, M. |
Publication Date | 1981 Apr 01 |
OSTI Identifier | OSTI ID: 5762424 |
Other Number(s) | CODEN: AIMDA |
Resource Type | Journal Article |
Resource Relation | Arch. Intern. Med. ; Vol/Issue: 141:5 |
Research Org | Harvard Medical School, Boston, MA |
Subject | 560151 -- Radiation Effects on Animals-- Man ;550603 -- Medicine-- External Radiation in Therapy-- (1980-); ;ARTERIOSCLEROSIS-- RADIOINDUCTION;FIBROSIS-- RADIOINDUCTION;HEART-- BIOLOGICAL RADIATION EFFECTS;RADIOTHERAPY-- SIDE EFFECTS; HODGKINS DISEASE;LOCAL IRRADIATION;PATHOLOGICAL CHANGES;PATIENTS |
Related Subject | BIOLOGICAL EFFECTS;BODY;CARDIOVASCULAR DISEASES;CARDIOVASCULAR SYSTEM;DISEASES;IRRADIATION;LYMPHOMAS;MEDICINE;NEOPLASMS;NUCLEAR MEDICINE;ORGANS;PATHOLOGICAL CHANGES;RADIATION EFFECTS;RADIOLOGY;THERAPY;VASCULAR DISEASES |
Description/Abstract | A 20-year-old man contracted Hodgkin`s disease and was treated with mantle radiotherapy.^Heart block developed 11 years later.^Electrocardiograms revealed predominant atrioventricular (AV) block and occasional AV conduction.^Intracardiac electrograms demonstrated that the site of AV block was above the level of the His bundle.^A permanent transvenous pacemaker was implanted.^Seven months later the patient died of complications from cryptococcal meningitis.^Pathological study of the heart revealed marked arteriosclerosis with fibrosis of the epicardium, myocardium, and endocardium.^Examination of the conduction system revealed extensive arteriolosclerosis of the sinoatrial node and its approaches.^In addition, there was marked fibrosis of the approaches to the AV node, the AV bundle, and both bundle branches.^There was no evidence of Hodgkin`s disease.^This case documents the rare occurrence of AV block due to tissue destruction by radiotherapy.^There was a good correlation between block proximal to the His bundle recording site and fibrosis of the approaches to the AV node. |
Country of Publication | United States |
Language | English |
Format | Pages: 676-679 |
System Entry Date | 2001 May 13 |
Top |