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Title Radiotherapy as a cause of complete atrioventricular block in Hodgkin`s disease: an electrophysiological-pathological correlation
Creator/Author Cohen, S.I. ; Bharati, S. ; Glass, J. ; Lev, M.
Publication Date1981 Apr 01
OSTI IdentifierOSTI ID: 5762424
Other Number(s)CODEN: AIMDA
Resource TypeJournal Article
Resource RelationArch. Intern. Med. ; Vol/Issue: 141:5
Research OrgHarvard Medical School, Boston, MA
Subject560151 -- Radiation Effects on Animals-- Man ;550603 -- Medicine-- External Radiation in Therapy-- (1980-); ;ARTERIOSCLEROSIS-- RADIOINDUCTION;FIBROSIS-- RADIOINDUCTION;HEART-- BIOLOGICAL RADIATION EFFECTS;RADIOTHERAPY-- SIDE EFFECTS; HODGKINS DISEASE;LOCAL IRRADIATION;PATHOLOGICAL CHANGES;PATIENTS
Related SubjectBIOLOGICAL EFFECTS;BODY;CARDIOVASCULAR DISEASES;CARDIOVASCULAR SYSTEM;DISEASES;IRRADIATION;LYMPHOMAS;MEDICINE;NEOPLASMS;NUCLEAR MEDICINE;ORGANS;PATHOLOGICAL CHANGES;RADIATION EFFECTS;RADIOLOGY;THERAPY;VASCULAR DISEASES
Description/Abstract A 20-year-old man contracted Hodgkin`s disease and was treated with mantle radiotherapy.^Heart block developed 11 years later.^Electrocardiograms revealed predominant atrioventricular (AV) block and occasional AV conduction.^Intracardiac electrograms demonstrated that the site of AV block was above the level of the His bundle.^A permanent transvenous pacemaker was implanted.^Seven months later the patient died of complications from cryptococcal meningitis.^Pathological study of the heart revealed marked arteriosclerosis with fibrosis of the epicardium, myocardium, and endocardium.^Examination of the conduction system revealed extensive arteriolosclerosis of the sinoatrial node and its approaches.^In addition, there was marked fibrosis of the approaches to the AV node, the AV bundle, and both bundle branches.^There was no evidence of Hodgkin`s disease.^This case documents the rare occurrence of AV block due to tissue destruction by radiotherapy.^There was a good correlation between block proximal to the His bundle recording site and fibrosis of the approaches to the AV node.
Country of PublicationUnited States
LanguageEnglish
FormatPages: 676-679
System Entry Date2001 May 13

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