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Pathology Tables for Peer Review
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NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97 Route: SKIN APPLICATION Time: 17:20:28 Facility: Hazleton, Maryland Chemical CAS #: 84-66-2 Lock Date: None Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All Page 1 NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97 Route: SKIN APPLICATION Time: 17:20:28 _____________________________________________________________________________________________________________________ | 1| 3| 3| 1| 3| 1| 1| 3| 1| 2| 3| 2| 3| 1| 1| 1| 1| 1| 3| 3| 1| 3| 1| 3| 3| DAY ON TEST | 4| 9| 9| 4| 2| 8| 4| 5| 4| 5| 2| 2| 8| 4| 4| 4| 4| 4| 2| 8| 4| 9| 4| 9| 9| | 1| 0| 0| 1| 7| 5| 1| 5| 1| 9| 9| 2| 8| 1| 1| 1| 1| 1| 0| 8| 2| 5| 6| 4| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CD-1 CRL MICE OUTBRED CHARLES MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| DMBA/TPA | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + | __________________________________________________________________________| Intestine Small | | __________________________________________________________________________| Intestine Small, Ileum | | Amyloid Deposition | | Granuloma | | __________________________________________________________________________| Liver | + + + | Abscess | 4 4 | Amyloid Deposition | | Angiectasis | | Hematopoietic Cell Proliferation | 4 2 | Necrosis | 3 2 | __________________________________________________________________________| Pancreas | | Abscess | | __________________________________________________________________________| Salivary Glands | | Hemorrhage | | Necrosis | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | | Abscess | | Inflammation, Chronic, Focal | | Atrium, Thrombosis | | Epicardium, Inflammation, Suppurative| | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | | __________________________________________________________________________| Adrenal Gland, Cortex | | __________________________________________________________________________| Adrenal Gland, Medulla | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Tissue NOS | | Abscess | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | | Cyst | | __________________________________________________________________________| Penis | | __________________________________________________________________________| Preputial Gland | + | Dilatation | 3 | __________________________________________________________________________| Seminal Vesicle | | Inflammation, Chronic | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + | _____________________________________________________________________________________________________________________| Page 2 NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97 Route: SKIN APPLICATION Time: 17:20:28 _____________________________________________________________________________________________________________________ | 1| 3| 3| 1| 3| 1| 1| 3| 1| 2| 3| 2| 3| 1| 1| 1| 1| 1| 3| 3| 1| 3| 1| 3| 3| DAY ON TEST | 4| 9| 9| 4| 2| 8| 4| 5| 4| 5| 2| 2| 8| 4| 4| 4| 4| 4| 2| 8| 4| 9| 4| 9| 9| | 1| 0| 0| 1| 7| 5| 1| 5| 1| 9| 9| 2| 8| 1| 1| 1| 1| 1| 0| 8| 2| 5| 6| 4| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CD-1 CRL MICE OUTBRED CHARLES MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| DMBA/TPA | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Abscess | | Cyst | X | Hematopoietic Cell Proliferation | 3 | Hyperplasia | 3 | Hyperplasia, Re Cell | 3 | Axillary, Abscess | 4 3 | Axillary, Cyst | X | Axillary, Depletion Lymphoid | 3 | Axillary, Hyperplasia | 4 3 4 3 4 3 4 4 4 4 3 4 4 | Inguinal, Hyperplasia | 3 3 | Lumbar, Hyperplasia | | Mediastinal, Abscess | | Mediastinal, Hyperplasia | | Renal, Hyperplasia | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + | Cyst | X | Depletion Lymphoid | 3 | Hematopoietic Cell Proliferation | 4 | Hyperplasia | 3 3 4 4 2 3 3 4 | __________________________________________________________________________| Lymph Node, Mesenteric | | Hematopoietic Cell Proliferation | | Hyperplasia | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + | Amyloid Deposition | 3 3 2 | Granuloma | | Hematopoietic Cell Proliferation | 2 3 4 4 4 4 3 4 3 4 3 3 3 3 3 4 3 3 3 | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + +| Other, Abscess | 4 | Other, Acanthosis, Focal | 4 | Other, Acanthosis | 2 3 2 2 2 3 2 2 2 2 3 2 3 2 | Other, Edema | | Other, Exudate | X X X X X X X X X X X X X | Other, Hyperkeratosis | 2 2 1 2 2 2 1 1 2 2 2 | Other, Inflammation, Subacute | 3 4 4 4 4 3 4 3 4 4 3 4 4 4 | Other, Ulcer | 2 4 4 4 4 3 3 3 4 4 4 4 4 4 | Sebaceous Gland, Site of | | Application-Mass, Hyperplasia | | Site of Application-Mass, Abscess | 4 | Site of Application-Mass, Acanthosis,| | Focal | 4 4 4 4 4 4 4 3| Site of Application-Mass, Acanthosis | 1 | Site of Application-Mass, Exudate | X | _____________________________________________________________________________________________________________________| Page 3 NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97 Route: SKIN APPLICATION Time: 17:20:28 _____________________________________________________________________________________________________________________ | 1| 3| 3| 1| 3| 1| 1| 3| 1| 2| 3| 2| 3| 1| 1| 1| 1| 1| 3| 3| 1| 3| 1| 3| 3| DAY ON TEST | 4| 9| 9| 4| 2| 8| 4| 5| 4| 5| 2| 2| 8| 4| 4| 4| 4| 4| 2| 8| 4| 9| 4| 9| 9| | 1| 0| 0| 1| 7| 5| 1| 5| 1| 9| 9| 2| 8| 1| 1| 1| 1| 1| 0| 8| 2| 5| 6| 4| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CD-1 CRL MICE OUTBRED CHARLES MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| DMBA/TPA | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | Site of Application-Mass, | | Hyperkeratosis, Focal | | Site of Application-Mass, | | Hyperplasia, Focal, Mast Cell | 2 | Site of Application-Mass, | | Inflammation, Subacute | 2 | Site of Application-Mass, | | Inflammation, Suppurative | 4 | __________________________________________________________________________| Skin, Control | + + + + + + + + + + + + + + + + + + + + + + + +| Hyperkeratosis | | Inflammation, Subacute | | __________________________________________________________________________| Skin, Site of Application-No Mass | + + + + + + + + + + + + + + + + + + + + + + + +| Abscess | | Acanthosis | 3 2 2 3 2 2 2 3 2 3 2 2 2 3 3 2 2 3 2 2 2 3| Cyst Epithelial Inclusion | | Exudate | X X X X X X X X X X X X X X X X X| Hyperkeratosis | 1 2 2 4 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2| Inflammation, Subacute | 4 1 3 2 2 4 2 4 2 1 3 3 1 3 4 2 1 3 2| Ulcer | 4 2 4 2 4 2 2 4 4 2 4 3| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | | Hemorrhage | 2 | Leukocytosis | 3 3 2 2 | Alveolar Epithelium, Hyperplasia | 3 | Alveolus, Infiltration Cellular, | | Histiocyte | 1 1 2 1 | Interstitium, Inflammation, Chronic, | | Focal | 2 1 2 | Interstitium, Inflammation | 2 2 2 2| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | | __________________________________________________________________________| Eye | + + | Cataract | 3 | Inflammation, Suppurative | | Cornea, Inflammation, Chronic | 3 | _____________________________________________________________________________________________________________________| Page 4 NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97 Route: SKIN APPLICATION Time: 17:20:28 _____________________________________________________________________________________________________________________ | 1| 3| 3| 1| 3| 1| 1| 3| 1| 2| 3| 2| 3| 1| 1| 1| 1| 1| 3| 3| 1| 3| 1| 3| 3| DAY ON TEST | 4| 9| 9| 4| 2| 8| 4| 5| 4| 5| 2| 2| 8| 4| 4| 4| 4| 4| 2| 8| 4| 9| 4| 9| 9| | 1| 0| 0| 1| 7| 5| 1| 5| 1| 9| 9| 2| 8| 1| 1| 1| 1| 1| 0| 8| 2| 5| 6| 4| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CD-1 CRL MICE OUTBRED CHARLES MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| DMBA/TPA | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM - cont | | | | Retrobulbar, Inflammation, Subacute | 3 | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + | Abscess | | Infiltration Cellular, Focal, Plasma | | Cell | 3 | Nephropathy | | Cortex, Atrophy | 4 4 | Papilla, Necrosis | 2 | Proximal Convoluted Renal Tubule, | | Vacuolization Cytoplasmic | 3 | _____________________________________________________________________________________________________________________| Page 5 NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97 Route: SKIN APPLICATION Time: 17:20:28 __________________________________________________________________________________________________________________________________ | 1| 2| 3| 1| 1| 1| 3| 2| 1| 3| 3| 3| 3| 1| 2| 1| 2| 3| 1| 1| 3| 1| 1| 1| 2| | DAY ON TEST | 4| 3| 8| 4| 4| 8| 1| 4| 4| 5| 9| 0| 4| 4| 9| 4| 6| 9| 4| 4| 9| 4| 3| 4| 7| | | 2| 0| 8| 2| 2| 0| 9| 9| 2| 2| 4| 4| 2| 2| 8| 2| 2| 4| 2| 2| 4| 2| 0| 2| 9| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | CD-1 CRL MICE OUTBRED CHARLES MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A | DMBA/TPA | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L | | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | | 1 | __________________________________________________________________________|____________| Intestine Small | + | 1 | __________________________________________________________________________|____________| Intestine Small, Ileum | + | 1 | Amyloid Deposition | 3 | 1 3.0| Granuloma | 4 | 1 4.0| __________________________________________________________________________|____________| Liver | + + + + +| 8 | Abscess | 1 4 4| 6 3.5| Amyloid Deposition | 3 4| 2 3.5| Angiectasis | 3 | 1 3.0| Hematopoietic Cell Proliferation | 3 | 3 3.0| Necrosis | 1 2 4| 6 2.7| __________________________________________________________________________|____________| Pancreas | + | 1 | Abscess | 4 | 1 4.0| __________________________________________________________________________|____________| Salivary Glands | + | 1 | Hemorrhage | 2 | 1 2.0| Necrosis | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + | 4 | Abscess | 4 | 1 4.0| Inflammation, Chronic, Focal | 3 | 1 3.0| Atrium, Thrombosis | X | 1 | Epicardium, Inflammation, Suppurative| 3 | 1 3.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + | 1 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + | 1 | __________________________________________________________________________|____________| Adrenal Gland, Medulla | + | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Tissue NOS | + + + | 3 | Abscess | 4 3 4 | 3 3.7| _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + | 1 | Cyst | X | 1 | __________________________________________________________________________|____________| Penis | + | 1 | __________________________________________________________________________|____________| Preputial Gland | | 1 | Dilatation | | 1 3.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 6 NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97 Route: SKIN APPLICATION Time: 17:20:28 __________________________________________________________________________________________________________________________________ | 1| 2| 3| 1| 1| 1| 3| 2| 1| 3| 3| 3| 3| 1| 2| 1| 2| 3| 1| 1| 3| 1| 1| 1| 2| | DAY ON TEST | 4| 3| 8| 4| 4| 8| 1| 4| 4| 5| 9| 0| 4| 4| 9| 4| 6| 9| 4| 4| 9| 4| 3| 4| 7| | | 2| 0| 8| 2| 2| 0| 9| 9| 2| 2| 4| 4| 2| 2| 8| 2| 2| 4| 2| 2| 4| 2| 0| 2| 9| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | CD-1 CRL MICE OUTBRED CHARLES MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A | DMBA/TPA | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L | | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Seminal Vesicle | + | 1 | Inflammation, Chronic | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + + + + +| 35 | Abscess | 4 | 1 4.0| Cyst | | 1 | Hematopoietic Cell Proliferation | | 1 3.0| Hyperplasia | 3 3 3 | 4 3.0| Hyperplasia, Re Cell | | 1 3.0| Axillary, Abscess | | 2 3.5| Axillary, Cyst | X | 2 | Axillary, Depletion Lymphoid | | 1 3.0| Axillary, Hyperplasia | 2 4 4 2 4 4 3 3 4 4 4 4 4 4 | 27 3.6| Inguinal, Hyperplasia | | 2 3.0| Lumbar, Hyperplasia | 3 | 1 3.0| Mediastinal, Abscess | 4 | 1 4.0| Mediastinal, Hyperplasia | 4 | 1 4.0| Renal, Hyperplasia | 3 | 1 3.0| __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + +| 23 | Cyst | | 1 | Depletion Lymphoid | | 1 3.0| Hematopoietic Cell Proliferation | | 1 4.0| Hyperplasia | 3 4 4 4 4 4 3 3 4 4 4 4 4| 21 3.6| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + +| 4 | Hematopoietic Cell Proliferation | 4 4| 2 4.0| Hyperplasia | 4 3 | 2 3.5| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + +| 42 | Amyloid Deposition | 2 3 2 2 3 3| 9 2.6| Granuloma | 4 | 1 4.0| Hematopoietic Cell Proliferation | 4 3 4 4 3 4 3 3 4 4 3 4 1 3 4 4 3 3 4 3 4 3 4| 43 3.4| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Other, Abscess | 4 4 4| 4 4.0| Other, Acanthosis, Focal | | 1 4.0| Other, Acanthosis | 2 2 3 2 2 2 2 2 3 3 1 3| 26 2.3| Other, Edema | 3 | 1 3.0| Other, Exudate | X X X X X X X X X| 22 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 7 NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97 Route: SKIN APPLICATION Time: 17:20:28 __________________________________________________________________________________________________________________________________ | 1| 2| 3| 1| 1| 1| 3| 2| 1| 3| 3| 3| 3| 1| 2| 1| 2| 3| 1| 1| 3| 1| 1| 1| 2| | DAY ON TEST | 4| 3| 8| 4| 4| 8| 1| 4| 4| 5| 9| 0| 4| 4| 9| 4| 6| 9| 4| 4| 9| 4| 3| 4| 7| | | 2| 0| 8| 2| 2| 0| 9| 9| 2| 2| 4| 4| 2| 2| 8| 2| 2| 4| 2| 2| 4| 2| 0| 2| 9| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | CD-1 CRL MICE OUTBRED CHARLES MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A | DMBA/TPA | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L | | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | __________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM - cont | | | | | | Other, Hyperkeratosis | 1 1 2 2 2 2 2 2| 19 1.7| Other, Inflammation, Subacute | 4 4 4 3 4 2 4 3 4 4 4| 25 3.7| Other, Ulcer | 4 4 4 4 3 4 4 3 4 4 4 4| 26 3.7| Sebaceous Gland, Site of | | | Application-Mass, Hyperplasia | 4 | 1 4.0| Site of Application-Mass, Abscess | 4 | 2 4.0| Site of Application-Mass, Acanthosis,| | | Focal | 2 3 4 | 11 3.6| Site of Application-Mass, Acanthosis | | 1 1.0| Site of Application-Mass, Exudate | | 1 | Site of Application-Mass, | | | Hyperkeratosis, Focal | 2 | 1 2.0| Site of Application-Mass, | | | Hyperplasia, Focal, Mast Cell | | 1 2.0| Site of Application-Mass, | | | Inflammation, Subacute | | 1 2.0| Site of Application-Mass, | | | Inflammation, Suppurative | | 1 4.0| __________________________________________________________________________|____________| Skin, Control | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hyperkeratosis | 2 | 1 2.0| Inflammation, Subacute | 2 1 | 2 1.5| __________________________________________________________________________|____________| Skin, Site of Application-No Mass | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Abscess | 4 2 | 2 3.0| Acanthosis | 1 2 2 2 2 2 2 2 2 3 2 2 3 2 2 3 3 2 2 2 2 3 2| 45 2.3| Cyst Epithelial Inclusion | X | 1 | Exudate | X X X X X X X X X X X X X X| 31 | Hyperkeratosis | 1 2 1 1 2 2 2 2 1 2 3 1 2 2 2 2 1 1 2 2| 39 1.8| Inflammation, Subacute | 2 4 2 2 2 4 3 3 4 4 3 4 2 4 3| 34 2.7| Ulcer | 4 4 4 4 4 4 4 4 2 4 | 22 3.4| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Congestion | 2| 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 8 NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97 Route: SKIN APPLICATION Time: 17:20:28 __________________________________________________________________________________________________________________________________ | 1| 2| 3| 1| 1| 1| 3| 2| 1| 3| 3| 3| 3| 1| 2| 1| 2| 3| 1| 1| 3| 1| 1| 1| 2| | DAY ON TEST | 4| 3| 8| 4| 4| 8| 1| 4| 4| 5| 9| 0| 4| 4| 9| 4| 6| 9| 4| 4| 9| 4| 3| 4| 7| | | 2| 0| 8| 2| 2| 0| 9| 9| 2| 2| 4| 4| 2| 2| 8| 2| 2| 4| 2| 2| 4| 2| 0| 2| 9| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | CD-1 CRL MICE OUTBRED CHARLES MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A | DMBA/TPA | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L | | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | Hemorrhage | 2 | 2 2.0| Leukocytosis | 2 2 4 3 2 4 3 2| 12 2.7| Alveolar Epithelium, Hyperplasia | | 1 3.0| Alveolus, Infiltration Cellular, | | | Histiocyte | 3 1 1 2 | 8 1.5| Interstitium, Inflammation, Chronic, | | | Focal | 1 | 4 1.5| Interstitium, Inflammation | 3 2 3 2 2 3 2 2 3| 13 2.3| _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Ear | + | 1 | __________________________________________________________________________|____________| Eye | + | 3 | Cataract | | 1 3.0| Inflammation, Suppurative | 3 | 1 3.0| Cornea, Inflammation, Chronic | | 1 3.0| Retrobulbar, Inflammation, Subacute | | 1 3.0| _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + +| 7 | Abscess | 4 4 | 2 4.0| Infiltration Cellular, Focal, Plasma | | | Cell | | 1 3.0| Nephropathy | 2 | 1 2.0| Cortex, Atrophy | | 2 4.0| Papilla, Necrosis | | 1 2.0| Proximal Convoluted Renal Tubule, | | | Vacuolization Cytoplasmic | | 1 3.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 9 NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97 Route: SKIN APPLICATION Time: 17:20:28 _____________________________________________________________________________________________________________________ | 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| DAY ON TEST | 8| 6| 6| 8| 8| 8| 8| 8| 9| 8| 9| 9| 9| 7| 8| 9| 9| 7| 5| 9| 9| 9| 9| 9| 9| | 7| 6| 8| 7| 7| 7| 7| 7| 9| 7| 4| 4| 4| 5| 3| 4| 4| 3| 6| 4| 5| 5| 5| 5| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CD-1 CRL MICE OUTBRED CHARLES MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| DMBA/ACE | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| TONE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Intestine Small | + | __________________________________________________________________________| Intestine Small, Duodenum | + | Inflammation, Subacute | 3 | __________________________________________________________________________| Liver | + + + + + + | Abscess | 4 4 | Amyloid Deposition | | Hematopoietic Cell Proliferation | 3 2 4 | Inflammation, Chronic, Focal | | __________________________________________________________________________| Mesentery | + + | Abscess | 4 | Fat, Necrosis, Focal | 2 | __________________________________________________________________________| Pancreas | +| Edema | 3| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + | Abscess | 4 | Amyloid Deposition | 3 | Atrium, Thrombosis | X | Epicardium, Inflammation, Suppurative| 4 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Thyroid Gland | | Amyloid Deposition | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Tissue NOS | + | Abscess | 4 | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Penis | | __________________________________________________________________________| Preputial Gland | + | Abscess | 4 | __________________________________________________________________________| Seminal Vesicle | + + + | Dilatation | 2 4 | Fibrosis | 3 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Lymph Node | + + + + + + +| Hyperplasia | | Axillary, Hyperplasia | | Mediastinal, Hyperplasia | 3 | Renal, Hyperplasia | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + | _____________________________________________________________________________________________________________________| Page 10 NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97 Route: SKIN APPLICATION Time: 17:20:28 _____________________________________________________________________________________________________________________ | 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| DAY ON TEST | 8| 6| 6| 8| 8| 8| 8| 8| 9| 8| 9| 9| 9| 7| 8| 9| 9| 7| 5| 9| 9| 9| 9| 9| 9| | 7| 6| 8| 7| 7| 7| 7| 7| 9| 7| 4| 4| 4| 5| 3| 4| 4| 3| 6| 4| 5| 5| 5| 5| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CD-1 CRL MICE OUTBRED CHARLES MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| DMBA/ACE | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| TONE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Abscess | 4 2 4 | Hyperplasia | 4 3 4 3 4 | __________________________________________________________________________| Lymph Node, Mesenteric | +| Depletion Lymphoid | 3| Hematopoietic Cell Proliferation | | __________________________________________________________________________| Spleen | + + + + + + + + +| Amyloid Deposition | 3 2 | Hematopoietic Cell Proliferation | 4 1 3 3 4 3 3 4 3| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Other, Abscess | 3 2 | Other, Acanthosis | 2 2 2 3 2 2 3 | Other, Edema | 3 | Other, Exudate | X X X X X | Other, Hyperkeratosis | 3 2 2 4 2 1 | Other, Inflammation, Subacute | 4 3 4 4 3 3 3 | Other, Ulcer | 4 4 4 4 4 3 | Site of Application-Mass, Acanthosis,| | Focal | | __________________________________________________________________________| Skin, Control | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skin, Site of Application-No Mass | + + + + + + + + + + + + + + + + + + + + + + + + +| Acanthosis | 2 2 1 3 2 1 3 3 1 2| Exudate | X X X X X| Hyperkeratosis | 2 2 2 2 2 1 2 2 1 2| Inflammation, Subacute | 2 3 2 4 2| Ulcer | 2 4 2| Sebaceous Gland, Hyperplasia, Focal | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Abscess | 4 | Congestion | | Inflammation, Chronic, Focal | | Leukocytosis | 4 2 3 1 | Alveolar Epithelium, Hyperplasia | 2 3 4 | Alveolus, Infiltration Cellular, | | Histiocyte | 2 3 | _____________________________________________________________________________________________________________________| Page 11 NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97 Route: SKIN APPLICATION Time: 17:20:28 _____________________________________________________________________________________________________________________ | 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| DAY ON TEST | 8| 6| 6| 8| 8| 8| 8| 8| 9| 8| 9| 9| 9| 7| 8| 9| 9| 7| 5| 9| 9| 9| 9| 9| 9| | 7| 6| 8| 7| 7| 7| 7| 7| 9| 7| 4| 4| 4| 5| 3| 4| 4| 3| 6| 4| 5| 5| 5| 5| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CD-1 CRL MICE OUTBRED CHARLES MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| DMBA/ACE | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| TONE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Bronchiole, Hyperplasia | 4 | Bronchiole, Inflammation, Suppurative| 4 | Bronchiole, Metaplasia | 4 | Interstitium, Inflammation, Chronic, | | Focal | 2 1 2 | Interstitium, Inflammation | 2 2 4 2 3| Pleura, Inflammation, Suppurative | 4 | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | | __________________________________________________________________________| Eye | + | Cornea, Inflammation, Chronic | 2 | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + | Abscess | | Amyloid Deposition | | Infiltration Cellular, Plasma Cell | 4 | Infiltration Cellular, Lymphocyte | | Nephropathy | 3 | Cortex, Atrophy | | Pelvis, Dilatation | | _____________________________________________________________________________________________________________________| Page 12 NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97 Route: SKIN APPLICATION Time: 17:20:28 __________________________________________________________________________________________________________________________________ | 3| 1| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | DAY ON TEST | 9| 4| 9| 9| 6| 8| 5| 8| 8| 8| 8| 8| 8| 8| 8| 9| 8| 9| 9| 9| 1| 9| 9| 9| 9| | | 5| 2| 5| 5| 1| 9| 0| 9| 9| 9| 9| 9| 9| 9| 9| 0| 6| 0| 0| 0| 6| 0| 0| 0| 0| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | CD-1 CRL MICE OUTBRED CHARLES MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| T | ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A | DMBA/ACE | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L | TONE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Intestine Small | | 1 | __________________________________________________________________________|____________| Intestine Small, Duodenum | | 1 | Inflammation, Subacute | | 1 3.0| __________________________________________________________________________|____________| Liver | + + + + | 10 | Abscess | 4 | 3 4.0| Amyloid Deposition | 3 | 1 3.0| Hematopoietic Cell Proliferation | 3 3 | 5 3.0| Inflammation, Chronic, Focal | 2 | 1 2.0| __________________________________________________________________________|____________| Mesentery | | 2 | Abscess | | 1 4.0| Fat, Necrosis, Focal | | 1 2.0| __________________________________________________________________________|____________| Pancreas | | 1 | Edema | | 1 3.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + | 4 | Abscess | | 1 4.0| Amyloid Deposition | 3 | 2 3.0| Atrium, Thrombosis | X | 2 | Epicardium, Inflammation, Suppurative| | 1 4.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Thyroid Gland | + | 1 | Amyloid Deposition | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Tissue NOS | + + + + | 5 | Abscess | 4 | 2 4.0| _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Penis | + + | 2 | __________________________________________________________________________|____________| Preputial Gland | | 1 | Abscess | | 1 4.0| __________________________________________________________________________|____________| Seminal Vesicle | + + | 5 | Dilatation | 4 2 | 4 3.0| Fibrosis | | 1 3.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Lymph Node | + + + + + + | 13 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 13 NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97 Route: SKIN APPLICATION Time: 17:20:28 __________________________________________________________________________________________________________________________________ | 3| 1| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | DAY ON TEST | 9| 4| 9| 9| 6| 8| 5| 8| 8| 8| 8| 8| 8| 8| 8| 9| 8| 9| 9| 9| 1| 9| 9| 9| 9| | | 5| 2| 5| 5| 1| 9| 0| 9| 9| 9| 9| 9| 9| 9| 9| 0| 6| 0| 0| 0| 6| 0| 0| 0| 0| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | CD-1 CRL MICE OUTBRED CHARLES MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| T | ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A | DMBA/ACE | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L | TONE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Hyperplasia | 3 | 1 3.0| Axillary, Hyperplasia | 4 3 | 2 3.5| Mediastinal, Hyperplasia | | 1 3.0| Renal, Hyperplasia | 3 | 1 3.0| __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + | 10 | Abscess | | 3 3.3| Hyperplasia | 3 3 4 3 4 | 10 3.5| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + | 3 | Depletion Lymphoid | | 1 3.0| Hematopoietic Cell Proliferation | 3 4 | 2 3.5| __________________________________________________________________________|____________| Spleen | + + + + + + + + | 17 | Amyloid Deposition | 2 3 2 | 5 2.4| Hematopoietic Cell Proliferation | 4 3 3 4 4 3 3 | 16 3.3| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Other, Abscess | 3 4 3 | 5 3.0| Other, Acanthosis | 2 2 3 2 3 3 3 3 | 15 2.5| Other, Edema | | 1 3.0| Other, Exudate | X X X X X X X | 12 | Other, Hyperkeratosis | 1 1 | 8 2.0| Other, Inflammation, Subacute | 4 4 4 4 3 4 4 | 14 3.6| Other, Ulcer | 4 4 4 4 3 4 4 4 4 | 15 3.9| Site of Application-Mass, Acanthosis,| | | Focal | 4 3 | 2 3.5| __________________________________________________________________________|____________| Skin, Control | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Skin, Site of Application-No Mass | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Acanthosis | 3 2 1 2 1 1 2 2 | 19 1.9| Exudate | X X X X X | 10 | Hyperkeratosis | 1 2 2 | 13 1.8| Inflammation, Subacute | 1 2 3 | 8 2.4| Ulcer | 3 1 1 2 | 7 2.1| Sebaceous Gland, Hyperplasia, Focal | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | None | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 14 NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97 Route: SKIN APPLICATION Time: 17:20:28 __________________________________________________________________________________________________________________________________ | 3| 1| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | DAY ON TEST | 9| 4| 9| 9| 6| 8| 5| 8| 8| 8| 8| 8| 8| 8| 8| 9| 8| 9| 9| 9| 1| 9| 9| 9| 9| | | 5| 2| 5| 5| 1| 9| 0| 9| 9| 9| 9| 9| 9| 9| 9| 0| 6| 0| 0| 0| 6| 0| 0| 0| 0| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | CD-1 CRL MICE OUTBRED CHARLES MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| T | ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A | DMBA/ACE | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L | TONE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Abscess | | 1 4.0| Congestion | 3 | 1 3.0| Inflammation, Chronic, Focal | 2 | 1 2.0| Leukocytosis | 2 3 3 | 7 2.6| Alveolar Epithelium, Hyperplasia | | 3 3.0| Alveolus, Infiltration Cellular, | | | Histiocyte | 2 | 3 2.3| Bronchiole, Hyperplasia | | 1 4.0| Bronchiole, Inflammation, Suppurative| | 1 4.0| Bronchiole, Metaplasia | | 1 4.0| Interstitium, Inflammation, Chronic, | | | Focal | 4 | 4 2.3| Interstitium, Inflammation | 3 1 1 | 8 2.3| Pleura, Inflammation, Suppurative | 2 | 2 3.0| _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Ear | + + + | 3 | __________________________________________________________________________|____________| Eye | | 1 | Cornea, Inflammation, Chronic | | 1 2.0| _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + | 5 | Abscess | 3 | 1 3.0| Amyloid Deposition | 2 2 | 2 2.0| Infiltration Cellular, Plasma Cell | | 1 4.0| Infiltration Cellular, Lymphocyte | 4 | 1 4.0| Nephropathy | | 1 3.0| Cortex, Atrophy | 3 | 1 3.0| Pelvis, Dilatation | 2 3 | 2 2.5| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 15 NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97 Route: SKIN APPLICATION Time: 17:20:28 _____________________________________________________________________________________________________________________ | 0| 1| 2| 1| 3| 1| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 1| 3| 1| 2| 1| 3| 1| 3| 3| DAY ON TEST | 5| 4| 8| 4| 9| 4| 9| 9| 2| 7| 9| 3| 2| 9| 4| 0| 4| 9| 4| 8| 9| 7| 4| 9| 9| | 3| 2| 3| 2| 4| 2| 4| 4| 2| 7| 3| 8| 3| 3| 1| 4| 2| 3| 2| 4| 7| 3| 1| 0| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CD-1 CRL MICE OUTBRED CHARLES MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| ACETONE/ | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| TPA | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Intestine Small | + | __________________________________________________________________________| Intestine Small, Duodenum | + | __________________________________________________________________________| Intestine Small, Ileum | | __________________________________________________________________________| Intestine Small, Jejunum | | __________________________________________________________________________| Liver | + + + + | Abscess | 4 4 | Amyloid Deposition | 3 1 | Clear Cell Focus | | Hematopoietic Cell Proliferation | 3 3 | Necrosis | 4 2 4 | __________________________________________________________________________| Stomach | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Tissue NOS | + | Abscess | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + | Hyperplasia | 2 | Axillary, Hyperplasia | 4 4 4 3 4 3 4 | Bronchial, Hyperplasia | | Inguinal, Hyperplasia | 4 | Lumbar, Hyperplasia | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + | Abscess | 4 4 | Cyst | | Hyperplasia | 4 3 4 4 3 4 4 4 4 | Lymphocyte, Necrosis | 2 | __________________________________________________________________________| Lymph Node, Mesenteric | + | Hyperplasia | | Lymphocyte, Necrosis | 3 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + | Amyloid Deposition | 3 3 2 | Hematopoietic Cell Proliferation | 3 3 3 3 4 4 4 4 4 4 2 3 3 2 3 3 | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | _____________________________________________________________________________________________________________________| Page 16 NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97 Route: SKIN APPLICATION Time: 17:20:28 _____________________________________________________________________________________________________________________ | 0| 1| 2| 1| 3| 1| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 1| 3| 1| 2| 1| 3| 1| 3| 3| DAY ON TEST | 5| 4| 8| 4| 9| 4| 9| 9| 2| 7| 9| 3| 2| 9| 4| 0| 4| 9| 4| 8| 9| 7| 4| 9| 9| | 3| 2| 3| 2| 4| 2| 4| 4| 2| 7| 3| 8| 3| 3| 1| 4| 2| 3| 2| 4| 7| 3| 1| 0| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CD-1 CRL MICE OUTBRED CHARLES MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| ACETONE/ | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| TPA | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Other, Abscess | 4 | Other, Acanthosis | 3 2 2 3 2 3 2 2 2 2 3 3 3 2 | Other, Exudate | X X X X X X X X X X X X | Other, Hyperkeratosis | 3 2 2 2 2 2 2 2 | Other, Inflammation, Subacute | 4 3 2 2 4 4 4 4 4 3 4 4 4 | Other, Ulcer | 4 4 4 2 4 4 4 4 4 4 3 3 4 4 4 | Site of Application-Mass, Acanthosis,| | Focal | | __________________________________________________________________________| Skin, Control | + + + + + + + + + + + + + + + + + + + + + + + + +| Acanthosis | 2 | Inflammation, Subacute | 2 | __________________________________________________________________________| Skin, Site of Application-No Mass | + + + + + + + + + + + + + + + + + + + + + + + + +| Acanthosis | 2 4 2 3 2 3 2 2 2 2 2 2 2 2 3 2 2 2 4 2 2 2 3| Cyst Epithelial Inclusion | X | Exudate | X X X X X X X X X X X X X | Hyperkeratosis | 2 2 3 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2| Inflammation, Subacute | 2 4 4 1 4 3 3 4 4 4 2 3 3| Ulcer | 4 4 4 4 3 3 3 2 4 4 4 1 4 2 3 3| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Abscess | | Congestion | 2 2 2 | Leukocytosis | X 3 2 4 2 2 | Alveolar Epithelium, Hyperplasia | 2 | Alveolus, Infiltration Cellular, | | Histiocyte | 1 2 1 | Interstitium, Inflammation | 3 2 2 3 3 2 2 | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | + + + + | __________________________________________________________________________| Eye | + + + + | Inflammation, Suppurative | 3 | Cornea, Hyperplasia, Chronic | 3 | Cornea, Hyperplasia, Focal | 2 | Cornea, Inflammation, Chronic | 3 | _____________________________________________________________________________________________________________________| Page 17 NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97 Route: SKIN APPLICATION Time: 17:20:28 _____________________________________________________________________________________________________________________ | 0| 1| 2| 1| 3| 1| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 1| 3| 1| 2| 1| 3| 1| 3| 3| DAY ON TEST | 5| 4| 8| 4| 9| 4| 9| 9| 2| 7| 9| 3| 2| 9| 4| 0| 4| 9| 4| 8| 9| 7| 4| 9| 9| | 3| 2| 3| 2| 4| 2| 4| 4| 2| 7| 3| 8| 3| 3| 1| 4| 2| 3| 2| 4| 7| 3| 1| 0| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CD-1 CRL MICE OUTBRED CHARLES MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| ACETONE/ | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| TPA | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM - cont | | | | __________________________________________________________________________| Zymbal's Gland | + | Dilatation | 3 | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + | Abscess | 3 | Amyloid Deposition | 2 | Hematopoietic Cell Proliferation | | Cortex, Atrophy | 3 | Pelvis, Dilatation | | __________________________________________________________________________| Urinary Bladder | | _____________________________________________________________________________________________________________________| Page 18 NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97 Route: SKIN APPLICATION Time: 17:20:28 __________________________________________________________________________________________________________________________________ | 3| 2| 3| 1| 3| 1| 3| 2| 3| 1| 3| 1| 1| 1| 3| 1| 3| 3| 3| 3| 3| 3| 1| 1| 1| | DAY ON TEST | 9| 2| 9| 4| 9| 4| 9| 6| 3| 8| 9| 4| 4| 4| 9| 4| 1| 9| 9| 9| 9| 2| 4| 0| 4| | | 0| 8| 0| 1| 0| 1| 0| 0| 7| 0| 0| 1| 1| 2| 0| 2| 7| 0| 0| 0| 3| 9| 2| 9| 2| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | CD-1 CRL MICE OUTBRED CHARLES MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T | ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A | ACETONE/ | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L | TPA | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Intestine Small | + | 2 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + | 2 | __________________________________________________________________________|____________| Intestine Small, Ileum | + | 1 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + | 1 | __________________________________________________________________________|____________| Liver | + + + + + + | 10 | Abscess | 4 4 3 3 | 6 3.7| Amyloid Deposition | 4 | 3 2.7| Clear Cell Focus | X | 1 | Hematopoietic Cell Proliferation | | 2 3.0| Necrosis | 4 3 4 3 | 7 3.4| __________________________________________________________________________|____________| Stomach | + | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Tissue NOS | + +| 3 | Abscess | 4 4| 2 4.0| _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + +| 24 | Hyperplasia | | 1 2.0| Axillary, Hyperplasia | 4 4 4 4 3 4 4| 14 3.8| Bronchial, Hyperplasia | 4| 1 4.0| Inguinal, Hyperplasia | 3 | 2 3.5| Lumbar, Hyperplasia | 3 | 1 3.0| __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + +| 17 | Abscess | 4 | 3 4.0| Cyst | X | 1 | Hyperplasia | 4 3 4 4 3 4| 15 3.7| Lymphocyte, Necrosis | | 1 2.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + | 2 | Hyperplasia | 3 | 1 3.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 19 NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97 Route: SKIN APPLICATION Time: 17:20:28 __________________________________________________________________________________________________________________________________ | 3| 2| 3| 1| 3| 1| 3| 2| 3| 1| 3| 1| 1| 1| 3| 1| 3| 3| 3| 3| 3| 3| 1| 1| 1| | DAY ON TEST | 9| 2| 9| 4| 9| 4| 9| 6| 3| 8| 9| 4| 4| 4| 9| 4| 1| 9| 9| 9| 9| 2| 4| 0| 4| | | 0| 8| 0| 1| 0| 1| 0| 0| 7| 0| 0| 1| 1| 2| 0| 2| 7| 0| 0| 0| 3| 9| 2| 9| 2| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | CD-1 CRL MICE OUTBRED CHARLES MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T | ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A | ACETONE/ | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L | TPA | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Lymphocyte, Necrosis | | 1 3.0| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + +| 28 | Amyloid Deposition | 3 3 3 2 | 7 2.7| Hematopoietic Cell Proliferation | 4 3 3 4 3 3 4 3 3 3 3 3| 28 3.3| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Other, Abscess | 3 3 | 3 3.3| Other, Acanthosis | 3 2 2 3 3 2 2 2 2 3 3| 25 2.4| Other, Exudate | X X X X X| 17 | Other, Hyperkeratosis | 2 1 2 2 1 1 1 2| 16 1.8| Other, Inflammation, Subacute | 3 3 4 2 2 4 4 4 3 4 4| 24 3.5| Other, Ulcer | 4 4 4 3 4 4 4 3 3 4 4| 26 3.7| Site of Application-Mass, Acanthosis,| | | Focal | 4 | 1 4.0| __________________________________________________________________________|____________| Skin, Control | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Acanthosis | | 1 2.0| Inflammation, Subacute | | 1 2.0| __________________________________________________________________________|____________| Skin, Site of Application-No Mass | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Acanthosis | 2 3 2 2 1 2 3 2 2 2 1 2 2 3 2 2 2 3 2 1 3 3 2 1| 47 2.2| Cyst Epithelial Inclusion | | 1 | Exudate | X X X X X X X X X X X X | 25 | Hyperkeratosis | 2 2 1 2 2 2 2 2 1 2 1 2 2 2 1 3 | 34 1.9| Inflammation, Subacute | 3 2 4 2 3 2 2 2 3 3 2 2 2 2 4 4 2| 30 2.8| Ulcer | 4 2 4 2 4 4 4 | 23 3.3| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Abscess | 4| 1 4.0| Congestion | | 3 2.0| Leukocytosis | 3 3 3 4 | 10 2.9| Alveolar Epithelium, Hyperplasia | | 1 2.0| Alveolus, Infiltration Cellular, | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 20 NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97 Route: SKIN APPLICATION Time: 17:20:28 __________________________________________________________________________________________________________________________________ | 3| 2| 3| 1| 3| 1| 3| 2| 3| 1| 3| 1| 1| 1| 3| 1| 3| 3| 3| 3| 3| 3| 1| 1| 1| | DAY ON TEST | 9| 2| 9| 4| 9| 4| 9| 6| 3| 8| 9| 4| 4| 4| 9| 4| 1| 9| 9| 9| 9| 2| 4| 0| 4| | | 0| 8| 0| 1| 0| 1| 0| 0| 7| 0| 0| 1| 1| 2| 0| 2| 7| 0| 0| 0| 3| 9| 2| 9| 2| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | CD-1 CRL MICE OUTBRED CHARLES MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| T | ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A | ACETONE/ | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L | TPA | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | Histiocyte | 2 | 4 1.5| Interstitium, Inflammation | 3 4 | 9 2.7| _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Ear | + | 5 | __________________________________________________________________________|____________| Eye | | 4 | Inflammation, Suppurative | | 1 3.0| Cornea, Hyperplasia, Chronic | | 1 3.0| Cornea, Hyperplasia, Focal | | 1 2.0| Cornea, Inflammation, Chronic | | 1 3.0| __________________________________________________________________________|____________| Zymbal's Gland | | 1 | Dilatation | | 1 3.0| _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + | 6 | Abscess | | 1 3.0| Amyloid Deposition | 3 2 | 3 2.3| Hematopoietic Cell Proliferation | 3 | 1 3.0| Cortex, Atrophy | 3 | 2 3.0| Pelvis, Dilatation | 2 2 | 2 2.0| __________________________________________________________________________|____________| Urinary Bladder | + | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 21 NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97 Route: SKIN APPLICATION Time: 17:20:28 _____________________________________________________________________________________________________________________ | 1| 1| 3| 2| 3| 3| 3| 3| 3| 2| 3| 3| 1| 3| 3| 1| 3| 1| 3| 3| 1| 1| 3| 2| 1| DAY ON TEST | 4| 4| 9| 4| 4| 4| 9| 9| 5| 5| 9| 9| 9| 8| 9| 4| 5| 4| 9| 9| 3| 3| 8| 3| 4| | 2| 2| 3| 8| 4| 5| 3| 3| 9| 9| 5| 5| 4| 6| 5| 2| 3| 2| 5| 5| 8| 8| 7| 5| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CD-1 CRL MICE OUTBRED CHARLES MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| DEP/TPA | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | | __________________________________________________________________________| Liver | + | Abscess | 4 | Amyloid Deposition | | Hematopoietic Cell Proliferation | 3 | Inflammation, Chronic, Focal | | Necrosis | 4 | __________________________________________________________________________| Mesentery | + | Fat, Necrosis, Focal | 3 | __________________________________________________________________________| Pancreas | | Edema | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | | Abscess | | Amyloid Deposition | | Atrium, Thrombosis | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Tissue NOS | | Abscess | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Penis | + + | __________________________________________________________________________| Preputial Gland | + + | Abscess | 4 4 | __________________________________________________________________________| Seminal Vesicle | + + + | Abscess | 4 | Dilatation | 4 3 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + +| Cyst | | Hyperplasia | 3 2 3 4 | Axillary, Hyperplasia, Focal, | | Lymphoid | | Axillary, Hyperplasia | 4 3 4 3 4 3 4 4| Axillary, Hyperplasia, Plasma Cell | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + | Abscess | 4 | Amyloid Deposition | | _____________________________________________________________________________________________________________________| Page 22 NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97 Route: SKIN APPLICATION Time: 17:20:28 _____________________________________________________________________________________________________________________ | 1| 1| 3| 2| 3| 3| 3| 3| 3| 2| 3| 3| 1| 3| 3| 1| 3| 1| 3| 3| 1| 1| 3| 2| 1| DAY ON TEST | 4| 4| 9| 4| 4| 4| 9| 9| 5| 5| 9| 9| 9| 8| 9| 4| 5| 4| 9| 9| 3| 3| 8| 3| 4| | 2| 2| 3| 8| 4| 5| 3| 3| 9| 9| 5| 5| 4| 6| 5| 2| 3| 2| 5| 5| 8| 8| 7| 5| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CD-1 CRL MICE OUTBRED CHARLES MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| DEP/TPA | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Hematopoietic Cell Proliferation | | Hyperplasia | 3 4 4 3 3 4 3 4 4 4 | Hyperplasia, Plasma Cell | 3 | __________________________________________________________________________| Lymph Node, Mesenteric | + + + | Hematopoietic Cell Proliferation | 3 3 3 | Hyperplasia | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + +| Amyloid Deposition | 2 3 | Hematopoietic Cell Proliferation | 3 3 4 3 3 3 3 3 3 3 3 3 4 4 4| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + +| Amyloid Deposition | | Other, Abscess | 2 3| Other, Acanthosis | 2 3 2 3 3 3 2 2 2 3 3 3| Other, Exudate | X X X X X X X X X X X| Other, Hyperkeratosis | 1 2 2 2 2 2 1 2 2 | Other, Inflammation, Subacute | 4 4 4 4 4 4 3 4 4 4 4 | Other, Ulcer | 4 4 4 4 4 4 4 3 4 4 4 4| Site of Application-Mass, Acanthosis,| | Focal | 4 | Site of Application-Mass, Acanthosis | | __________________________________________________________________________| Skin, Control | + + + + + + + + + + + + + + + + + + + + + + + +| Exudate | | Inflammation, Subacute | 3 | Ulcer | | __________________________________________________________________________| Skin, Site of Application-No Mass | + + + + + + + + + + + + + + + + + + + + + + + +| Acanthosis | 3 3 2 3 2 3 2 2 2 2 2 2 3 2 2 3 2 3 2 2 3 2| Exudate | X X X X X X X X X X X X X X X| Hyperkeratosis | 2 3 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2| Inflammation, Subacute | 4 2 1 3 2 2 2 2 3 2 3 2 3 4 2 1 2 3 4 2 2 3| Ulcer | 4 2 4 3 2 4 2 3 4 4 4 2 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + +| Abscess | | Congestion | 3| Leukocytosis | 2 | _____________________________________________________________________________________________________________________| Page 23 NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97 Route: SKIN APPLICATION Time: 17:20:28 _____________________________________________________________________________________________________________________ | 1| 1| 3| 2| 3| 3| 3| 3| 3| 2| 3| 3| 1| 3| 3| 1| 3| 1| 3| 3| 1| 1| 3| 2| 1| DAY ON TEST | 4| 4| 9| 4| 4| 4| 9| 9| 5| 5| 9| 9| 9| 8| 9| 4| 5| 4| 9| 9| 3| 3| 8| 3| 4| | 2| 2| 3| 8| 4| 5| 3| 3| 9| 9| 5| 5| 4| 6| 5| 2| 3| 2| 5| 5| 8| 8| 7| 5| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CD-1 CRL MICE OUTBRED CHARLES MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| DEP/TPA | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Alveolus, Infiltration Cellular, | | Histiocyte | 1 2 | Interstitium, Inflammation, Chronic, | | Focal | 1 2 2 | Interstitium, Inflammation | 2 2 3 2 1 | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | + + | __________________________________________________________________________| Eye | | Lids, Inflammation, Chronic | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + | Amyloid Deposition | 2 | Cortex, Atrophy | 3 | Cortex, Cyst | X | Pelvis, Dilatation | | __________________________________________________________________________| Urethra | | Inflammation, Acute | | __________________________________________________________________________| Urinary Bladder | + + | Amyloid Deposition | | Hemorrhage | | Submucosa, Hemorrhage | | _____________________________________________________________________________________________________________________| Page 24 NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97 Route: SKIN APPLICATION Time: 17:20:28 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 2| 3| 1| 1| 1| 1| 1| 2| 2| 1| 1| 3| 1| 3| 3| 1| 3| 1| 3| 3| 2| | DAY ON TEST | 3| 3| 3| 4| 8| 3| 4| 4| 2| 4| 4| 2| 5| 4| 4| 8| 4| 8| 8| 4| 8| 4| 8| 8| 6| | | 8| 8| 8| 8| 8| 7| 1| 1| 6| 1| 1| 5| 9| 1| 1| 3| 1| 9| 9| 1| 9| 1| 9| 9| 4| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | CD-1 CRL MICE OUTBRED CHARLES MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| T | ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A | DEP/TPA | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L | | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + | 1 | __________________________________________________________________________|____________| Liver | + + + + + +| 7 | Abscess | 4 4 4 4 | 5 4.0| Amyloid Deposition | 2 | 1 2.0| Hematopoietic Cell Proliferation | 3 2 1 | 4 2.3| Inflammation, Chronic, Focal | 2 | 1 2.0| Necrosis | 4 3| 3 3.7| __________________________________________________________________________|____________| Mesentery | | 1 | Fat, Necrosis, Focal | | 1 3.0| __________________________________________________________________________|____________| Pancreas | + | 1 | Edema | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + | 2 | Abscess | 4 | 1 4.0| Amyloid Deposition | 2 | 1 2.0| Atrium, Thrombosis | X | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Tissue NOS | + | 1 | Abscess | 4 | 1 4.0| _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Penis | + | 3 | __________________________________________________________________________|____________| Preputial Gland | | 2 | Abscess | | 2 4.0| __________________________________________________________________________|____________| Seminal Vesicle | + | 4 | Abscess | | 1 4.0| Dilatation | 4 | 3 3.7| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + + + + +| 35 | Cyst | X | 1 | Hyperplasia | 1 | 5 2.6| Axillary, Hyperplasia, Focal, | | | Lymphoid | 3 | 1 3.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 25 NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97 Route: SKIN APPLICATION Time: 17:20:28 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 2| 3| 1| 1| 1| 1| 1| 2| 2| 1| 1| 3| 1| 3| 3| 1| 3| 1| 3| 3| 2| | DAY ON TEST | 3| 3| 3| 4| 8| 3| 4| 4| 2| 4| 4| 2| 5| 4| 4| 8| 4| 8| 8| 4| 8| 4| 8| 8| 6| | | 8| 8| 8| 8| 8| 7| 1| 1| 6| 1| 1| 5| 9| 1| 1| 3| 1| 9| 9| 1| 9| 1| 9| 9| 4| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | CD-1 CRL MICE OUTBRED CHARLES MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| T | ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A | DEP/TPA | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L | | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Axillary, Hyperplasia | 4 4 3 3 4 4 4 4 4 4 3 | 19 3.7| Axillary, Hyperplasia, Plasma Cell | 4 | 1 4.0| __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + +| 22 | Abscess | 4 | 2 4.0| Amyloid Deposition | 2 | 1 2.0| Hematopoietic Cell Proliferation | 4 3| 2 3.5| Hyperplasia | 4 4 4 4 4 3 3 3| 18 3.6| Hyperplasia, Plasma Cell | 4 | 2 3.5| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + | 5 | Hematopoietic Cell Proliferation | 4 | 4 3.3| Hyperplasia | 2 | 1 2.0| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + +| 32 | Amyloid Deposition | 2 | 3 2.3| Hematopoietic Cell Proliferation | 4 3 3 4 4 3 2 4 4 3 3 4 3 3 3 3 4| 32 3.3| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Amyloid Deposition | 2 | 1 2.0| Other, Abscess | 4 4| 4 3.3| Other, Acanthosis | 3 3 3 2 3 4 3 3 2 2 3 2 2 3 3| 27 2.7| Other, Exudate | X X X X X X X X X X X X| 23 | Other, Hyperkeratosis | 2 2 2 2 2 2 2 3 2| 18 1.9| Other, Inflammation, Subacute | 4 4 4 4 3 4 3 4 4 4 2 2 3 4| 26 3.7| Other, Ulcer | 4 4 4 2 4 4 4 4 4 4 2 2 2 4| 26 3.7| Site of Application-Mass, Acanthosis,| | | Focal | | 1 4.0| Site of Application-Mass, Acanthosis | 3| 1 3.0| __________________________________________________________________________|____________| Skin, Control | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Exudate | X | 1 | Inflammation, Subacute | 4 | 2 3.5| Ulcer | 4 | 1 4.0| __________________________________________________________________________|____________| Skin, Site of Application-No Mass | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Acanthosis | 2 2 3 2 2 3 3 2 2 3 2 2 2 3 2 2 2 3 2 2 | 43 2.4| Exudate | X X X X X X X X X X X X X X X X X | 32 | Hyperkeratosis | 1 2 2 3 2 2 2 2 2 2 3 1 2 | 31 2.0| Inflammation, Subacute | 4 2 4 2 4 2 2 2 3 2 4 4 4 2 2 | 38 2.7| Ulcer | 4 2 4 4 4 4 2 2 1 2 4 4 3 | 25 3.1| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | None | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 26 NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97 Route: SKIN APPLICATION Time: 17:20:28 __________________________________________________________________________________________________________________________________ | 1| 1| 1| 1| 2| 3| 1| 1| 1| 1| 1| 2| 2| 1| 1| 3| 1| 3| 3| 1| 3| 1| 3| 3| 2| | DAY ON TEST | 3| 3| 3| 4| 8| 3| 4| 4| 2| 4| 4| 2| 5| 4| 4| 8| 4| 8| 8| 4| 8| 4| 8| 8| 6| | | 8| 8| 8| 8| 8| 7| 1| 1| 6| 1| 1| 5| 9| 1| 1| 3| 1| 9| 9| 1| 9| 1| 9| 9| 4| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | CD-1 CRL MICE OUTBRED CHARLES MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| T | ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A | DEP/TPA | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L | | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | __________________________________________________________________________________________________________________________________ NERVOUS SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Abscess | 4 | 1 4.0| Congestion | 2 | 2 2.5| Leukocytosis | 1 4 3 1 1| 6 2.0| Alveolus, Infiltration Cellular, | | | Histiocyte | 3 1 | 4 1.8| Interstitium, Inflammation, Chronic, | | | Focal | 2 3 | 5 2.0| Interstitium, Inflammation | 2 2 2 | 8 2.0| _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Ear | | 2 | __________________________________________________________________________|____________| Eye | +| 1 | Lids, Inflammation, Chronic | 2| 1 2.0| _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + +| 6 | Amyloid Deposition | 1 3 | 3 2.0| Cortex, Atrophy | | 1 3.0| Cortex, Cyst | | 1 | Pelvis, Dilatation | 3 3 | 2 3.0| __________________________________________________________________________|____________| Urethra | + | 1 | Inflammation, Acute | 3 | 1 3.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + | 6 | Amyloid Deposition | 4 | 1 4.0| Hemorrhage | 3 | 1 3.0| Submucosa, Hemorrhage | 4 | 1 4.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 27 NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97 Route: SKIN APPLICATION Time: 17:20:28 _____________________________________________________________________________________________________________________ | 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 1| 3| 3| 3| 3| 3| 1| 3| 3| DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 7| 8| 9| 9| 5| 9| 9| 9| 4| 9| 9| 9| 8| 6| 4| 6| 8| | 4| 8| 8| 8| 8| 6| 8| 8| 7| 8| 3| 3| 0| 3| 2| 4| 2| 4| 4| 4| 9| 4| 1| 8| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CD-1 CRL MICE OUTBRED CHARLES MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| DEP/ACET | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| ONE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Intestine Small | + | __________________________________________________________________________| Intestine Small, Jejunum | + | Amyloid Deposition | 2 | __________________________________________________________________________| Liver | + + + + + + | Abscess | | Amyloid Deposition | 2 2 | Inflammation, Chronic, Focal | 2 | Necrosis | 2 | Vacuolization Cytoplasmic | | __________________________________________________________________________| Pancreas | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + | Abscess | 4 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Thyroid Gland | + | Amyloid Deposition | 2 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Tissue NOS | | Abscess | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Penis | + | __________________________________________________________________________| Preputial Gland | + | Abscess | 4 | Dilatation | | __________________________________________________________________________| Seminal Vesicle | + + | Dilatation | 3 4 | Inflammation | | __________________________________________________________________________| Testes | + | Tunic, Fibrosis | 3 | Tunic, Inflammation | 2 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Lymph Node | + + + + + + + + +| Abscess | | Cyst | | Hyperplasia | | Axillary, Hyperplasia | 4 4 | __________________________________________________________________________| Lymph Node, Mandibular | + + + M + + + + +| Abscess | | Hyperplasia | 2 3 3 3 4 4 3 3| _____________________________________________________________________________________________________________________| Page 28 NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97 Route: SKIN APPLICATION Time: 17:20:28 _____________________________________________________________________________________________________________________ | 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 1| 3| 3| 3| 3| 3| 1| 3| 3| DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 7| 8| 9| 9| 5| 9| 9| 9| 4| 9| 9| 9| 8| 6| 4| 6| 8| | 4| 8| 8| 8| 8| 6| 8| 8| 7| 8| 3| 3| 0| 3| 2| 4| 2| 4| 4| 4| 9| 4| 1| 8| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CD-1 CRL MICE OUTBRED CHARLES MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| DEP/ACET | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| ONE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Lymphatic, Dilatation | | __________________________________________________________________________| Lymph Node, Mesenteric | + | Amyloid Deposition | 2 | Hematopoietic Cell Proliferation | 4 | Hyperplasia | | __________________________________________________________________________| Spleen | + + + +| Amyloid Deposition | 3 | Hematopoietic Cell Proliferation | 3 4 3 3| __________________________________________________________________________| Thymus | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Other, Abscess | | Other, Acanthosis | 2 3 3 3 2 3 2 3 3 2| Other, Edema | 3 2 3 | Other, Exudate | X X X X X X X X| Other, Hyperkeratosis | 2 2 2 2 | Other, Inflammation, Subacute | 4 2 4 2 3 4 4 3 4| Other, Ulcer | 4 2 3 1 4 4 4 4 3 4| Subcutaneous Tissue, Other, Exudate, | | Focal | 4 | __________________________________________________________________________| Skin, Control | + + + + + + + + + + + + + + + + + + + + + + + + +| Acanthosis | 2 | Edema | 2 | Ulcer | 3 | __________________________________________________________________________| Skin, Site of Application-No Mass | + + + + + + + + + + + + + + + + + + + + + + + + +| Acanthosis | 1 2 1 2 1 1 2 2 2| Exudate | X X X X X X X X| Hyperkeratosis | 2 2 2 2 2 2 2| Inflammation, Subacute | 1 2 3 3 | Ulcer | 2 2 4 4 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Abscess | 4 | Congestion | 2 | Granuloma | | Hemorrhage | 3 2 1 | _____________________________________________________________________________________________________________________| Page 29 NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97 Route: SKIN APPLICATION Time: 17:20:28 _____________________________________________________________________________________________________________________ | 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 1| 3| 3| 3| 3| 3| 1| 3| 3| DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 7| 8| 9| 9| 5| 9| 9| 9| 4| 9| 9| 9| 8| 6| 4| 6| 8| | 4| 8| 8| 8| 8| 6| 8| 8| 7| 8| 3| 3| 0| 3| 2| 4| 2| 4| 4| 4| 9| 4| 1| 8| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CD-1 CRL MICE OUTBRED CHARLES MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| DEP/ACET | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| ONE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Inflammation, Chronic, Focal | 2 | Leukocytosis | 3 3 2 3 2 | Alveolar Epithelium, Hyperplasia | 2 | Alveolus, Infiltration Cellular, | | Histiocyte | 3 2 2 2 3 1 | Interstitium, Inflammation, Chronic, | | Focal | 2 3 3 | Interstitium, Inflammation | 1 3 2 2 2 1 | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | + | __________________________________________________________________________| Eye | + + | Cornea, Inflammation, Chronic | 1 2 | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + | Amyloid Deposition | 4 2 | Cortex, Atrophy | 3 | Cortex, Cyst | X | Pelvis, Dilatation | | Proximal Convoluted Renal Tubule, | | Vacuolization Cytoplasmic | | _____________________________________________________________________________________________________________________| Page 30 NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97 Route: SKIN APPLICATION Time: 17:20:28 __________________________________________________________________________________________________________________________________ | 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| | DAY ON TEST | 8| 8| 8| 8| 8| 7| 1| 8| 8| 8| 8| 8| 8| 4| 8| 9| 8| 9| 9| 6| 9| 9| 9| 9| 9| | | 9| 9| 9| 9| 9| 3| 8| 8| 8| 8| 8| 8| 8| 1| 5| 3| 2| 3| 3| 4| 3| 3| 3| 3| 3| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | CD-1 CRL MICE OUTBRED CHARLES MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T | ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A | DEP/ACET | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L | ONE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Intestine Small | | 1 | __________________________________________________________________________|____________| Intestine Small, Jejunum | | 1 | Amyloid Deposition | | 1 2.0| __________________________________________________________________________|____________| Liver | + + + | 9 | Abscess | 4 | 1 4.0| Amyloid Deposition | | 2 2.0| Inflammation, Chronic, Focal | 1 2 | 3 1.7| Necrosis | | 1 2.0| Vacuolization Cytoplasmic | 2 | 1 2.0| __________________________________________________________________________|____________| Pancreas | M | | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | | 1 | Abscess | | 1 4.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Thyroid Gland | | 1 | Amyloid Deposition | | 1 2.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Tissue NOS | + + + + + + | 6 | Abscess | 4 | 1 4.0| _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Penis | | 1 | __________________________________________________________________________|____________| Preputial Gland | + | 2 | Abscess | | 1 4.0| Dilatation | 3 | 1 3.0| __________________________________________________________________________|____________| Seminal Vesicle | + + + + | 6 | Dilatation | 3 3 3 | 5 3.2| Inflammation | 2 2 | 2 2.0| __________________________________________________________________________|____________| Testes | | 1 | Tunic, Fibrosis | | 1 3.0| Tunic, Inflammation | | 1 2.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + | 18 | Abscess | 4 | 1 4.0| Cyst | X | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 31 NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97 Route: SKIN APPLICATION Time: 17:20:28 __________________________________________________________________________________________________________________________________ | 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| | DAY ON TEST | 8| 8| 8| 8| 8| 7| 1| 8| 8| 8| 8| 8| 8| 4| 8| 9| 8| 9| 9| 6| 9| 9| 9| 9| 9| | | 9| 9| 9| 9| 9| 3| 8| 8| 8| 8| 8| 8| 8| 1| 5| 3| 2| 3| 3| 4| 3| 3| 3| 3| 3| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | CD-1 CRL MICE OUTBRED CHARLES MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T | ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A | DEP/ACET | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L | ONE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Hyperplasia | 3 | 1 3.0| Axillary, Hyperplasia | 4 4 | 4 4.0| __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + | 16 | Abscess | 4 | 1 4.0| Hyperplasia | 4 3 4 4 4 3 | 14 3.4| Lymphatic, Dilatation | 2 | 1 2.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + | 2 | Amyloid Deposition | | 1 2.0| Hematopoietic Cell Proliferation | | 1 4.0| Hyperplasia | 2 | 1 2.0| __________________________________________________________________________|____________| Spleen | + + + + + + + + + | 13 | Amyloid Deposition | 3 | 2 3.0| Hematopoietic Cell Proliferation | 3 4 3 3 3 4 4 3 | 12 3.3| __________________________________________________________________________|____________| Thymus | + | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Other, Abscess | 4 | 1 4.0| Other, Acanthosis | 3 2 3 3 2 2 2 2 | 18 2.5| Other, Edema | 3 | 4 2.8| Other, Exudate | X X X X X X | 14 | Other, Hyperkeratosis | 2 1 | 6 1.8| Other, Inflammation, Subacute | 4 4 4 4 4 4 3 | 16 3.6| Other, Ulcer | 4 4 4 4 4 3 3 3 | 18 3.4| Subcutaneous Tissue, Other, Exudate, | | | Focal | | 1 4.0| __________________________________________________________________________|____________| Skin, Control | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Acanthosis | | 1 2.0| Edema | | 1 2.0| Ulcer | | 1 3.0| __________________________________________________________________________|____________| Skin, Site of Application-No Mass | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Acanthosis | 2 2 2 2 2 | 14 1.7| Exudate | X X X | 11 | Hyperkeratosis | 1 | 8 1.9| Inflammation, Subacute | 2 2 2 | 7 2.1| Ulcer | 3 2 | 6 2.8| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | None | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 32 NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97 Route: SKIN APPLICATION Time: 17:20:28 __________________________________________________________________________________________________________________________________ | 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| | DAY ON TEST | 8| 8| 8| 8| 8| 7| 1| 8| 8| 8| 8| 8| 8| 4| 8| 9| 8| 9| 9| 6| 9| 9| 9| 9| 9| | | 9| 9| 9| 9| 9| 3| 8| 8| 8| 8| 8| 8| 8| 1| 5| 3| 2| 3| 3| 4| 3| 3| 3| 3| 3| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | CD-1 CRL MICE OUTBRED CHARLES MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| T | ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A | DEP/ACET | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L | ONE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | __________________________________________________________________________________________________________________________________ NERVOUS SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Abscess | | 1 4.0| Congestion | | 1 2.0| Granuloma | 2 | 1 2.0| Hemorrhage | 2 1 | 5 1.8| Inflammation, Chronic, Focal | | 1 2.0| Leukocytosis | 2 | 6 2.5| Alveolar Epithelium, Hyperplasia | 2 | 2 2.0| Alveolus, Infiltration Cellular, | | | Histiocyte | 1 2 | 8 2.0| Interstitium, Inflammation, Chronic, | | | Focal | 2 2 2 1 2 | 8 2.1| Interstitium, Inflammation | 2 2 2 3 | 10 2.0| _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Ear | + + | 3 | __________________________________________________________________________|____________| Eye | | 2 | Cornea, Inflammation, Chronic | | 2 1.5| _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + | 5 | Amyloid Deposition | 3 4 | 4 3.3| Cortex, Atrophy | 3 | 2 3.0| Cortex, Cyst | | 1 | Pelvis, Dilatation | 2 2 | 2 2.0| Proximal Convoluted Renal Tubule, | | | Vacuolization Cytoplasmic | 4 | 1 4.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 33 NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97 Route: SKIN APPLICATION Time: 17:20:28 _____________________________________________________________________________________________________________________ | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 3| 8| 8| 5| 8| 8| 1| 8| 8| 8| 8| 8| 8| 8| | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 7| 3| 7| 7| 7| 7| 7| 2| 7| 5| 7| 7| 7| 7| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CD-1 CRL MICE OUTBRED CHARLES MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| DMBA/DEP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Intestine Small | | __________________________________________________________________________| Intestine Small, Ileum | | Granuloma | | __________________________________________________________________________| Liver | + + + + + + | Amyloid Deposition | 3 | Basophilic Focus | | Hematopoietic Cell Proliferation | 3 2 | Inflammation, Chronic, Focal | 2 | Necrosis | 2 | Vacuolization Cytoplasmic | 2 | Centrilobular, Cytomegaly | 2 | __________________________________________________________________________| Mesentery | | Inflammation, Chronic | | __________________________________________________________________________| Pancreas | | Edema | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Tissue NOS | + | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | | Inflammation | | Spermatocele | | __________________________________________________________________________| Penis | + | Edema | 2 | __________________________________________________________________________| Preputial Gland | + + | Abscess | 4 | Dilatation | 2 | Inflammation, Chronic | 3 | __________________________________________________________________________| Seminal Vesicle | + + + | Dilatation | 2 3 4 | Fibrosis | 2 | __________________________________________________________________________| Testes | + | Seminiferous Tubule, Atrophy | 3 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Lymph Node | + + + + | __________________________________________________________________________| Lymph Node, Mandibular | + + + | _____________________________________________________________________________________________________________________| Page 34 NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97 Route: SKIN APPLICATION Time: 17:20:28 _____________________________________________________________________________________________________________________ | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 3| 8| 8| 5| 8| 8| 1| 8| 8| 8| 8| 8| 8| 8| | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 7| 3| 7| 7| 7| 7| 7| 2| 7| 5| 7| 7| 7| 7| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CD-1 CRL MICE OUTBRED CHARLES MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| DMBA/DEP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Abscess | 4 4 | Hematopoietic Cell Proliferation | 3 | Hyperplasia | 4 3 | __________________________________________________________________________| Lymph Node, Mesenteric | + | Hemorrhage | 3 | Infarct | | __________________________________________________________________________| Spleen | + + + + + + + | Amyloid Deposition | 2 2 | Hematopoietic Cell Proliferation | 3 3 2 3 3 2 3 | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Other, Abscess | | Other, Acanthosis | 1 3 3 3 | Other, Edema | 3 | Other, Exudate | X X X | Other, Hyperkeratosis | 2 | Other, Inflammation, Subacute | 3 4 4 2 | Other, Ulcer | 3 4 3 4 | Sebaceous Gland, Site of | | Application-Mass, Hyperplasia | 4 | __________________________________________________________________________| Skin, Control | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Subacute | 2 | Ulcer | 2 | __________________________________________________________________________| Skin, Site of Application-No Mass | + + + + + + + + + + + + + + + + + + + + + + + + +| Acanthosis | 3 2 3 2 | Exudate | X X X | Hyperkeratosis | 2 2 2 2 | Hyperplasia, Focal, Mast Cell | 2 | Inflammation, Subacute | 2 4 | Ulcer | 2 4 1 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Spinal Cord | + | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | | Hemorrhage | 2 2 | Leukocytosis | 2 | Alveolar Epithelium, Hyperplasia | 2 2 | _____________________________________________________________________________________________________________________| Page 35 NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97 Route: SKIN APPLICATION Time: 17:20:28 _____________________________________________________________________________________________________________________ | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 3| 8| 8| 5| 8| 8| 1| 8| 8| 8| 8| 8| 8| 8| | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 7| 3| 7| 7| 7| 7| 7| 2| 7| 5| 7| 7| 7| 7| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CD-1 CRL MICE OUTBRED CHARLES MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| DMBA/DEP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Alveolus, Infiltration Cellular, | | Histiocyte | 2 | Interstitium, Inflammation, Chronic, | | Focal | 1 2 3 2 | Interstitium, Inflammation | 2 3 3 | __________________________________________________________________________| Trachea | | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | + | __________________________________________________________________________| Eye | + | Cornea, Inflammation, Chronic | 3 | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + | Amyloid Deposition | 2 4 3 3 | Cortex, Cyst | X | Pelvis, Dilatation | 2 3 1 | __________________________________________________________________________| Urinary Bladder | + | _____________________________________________________________________________________________________________________| Page 36 NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97 Route: SKIN APPLICATION Time: 17:20:28 __________________________________________________________________________________________________________________________________ | 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| | DAY ON TEST | 8| 8| 8| 8| 8| 9| 4| 9| 9| 9| 9| 9| 9| 9| 4| 8| 8| 8| 8| 8| 8| 4| 8| 8| 8| | | 7| 7| 7| 7| 7| 3| 5| 3| 3| 3| 3| 3| 3| 3| 2| 8| 8| 8| 8| 8| 8| 9| 8| 8| 8| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | CD-1 CRL MICE OUTBRED CHARLES MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| T | ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A | DMBA/DEP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L | | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Intestine Small | + | 1 | __________________________________________________________________________|____________| Intestine Small, Ileum | + | 1 | Granuloma | 4 | 1 4.0| __________________________________________________________________________|____________| Liver | + + | 8 | Amyloid Deposition | | 1 3.0| Basophilic Focus | X | 1 | Hematopoietic Cell Proliferation | | 2 2.5| Inflammation, Chronic, Focal | | 1 2.0| Necrosis | | 1 2.0| Vacuolization Cytoplasmic | | 1 2.0| Centrilobular, Cytomegaly | | 1 2.0| __________________________________________________________________________|____________| Mesentery | + | 1 | Inflammation, Chronic | 3 | 1 3.0| __________________________________________________________________________|____________| Pancreas | + | 1 | Edema | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Tissue NOS | + + +| 4 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + | 1 | Inflammation | 2 | 1 2.0| Spermatocele | X | 1 | __________________________________________________________________________|____________| Penis | | 1 | Edema | | 1 2.0| __________________________________________________________________________|____________| Preputial Gland | | 2 | Abscess | | 1 4.0| Dilatation | | 1 2.0| Inflammation, Chronic | | 1 3.0| __________________________________________________________________________|____________| Seminal Vesicle | + + + | 6 | Dilatation | 3 3 3 | 6 3.0| Fibrosis | | 1 2.0| __________________________________________________________________________|____________| Testes | + | 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 37 NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97 Route: SKIN APPLICATION Time: 17:20:28 __________________________________________________________________________________________________________________________________ | 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| | DAY ON TEST | 8| 8| 8| 8| 8| 9| 4| 9| 9| 9| 9| 9| 9| 9| 4| 8| 8| 8| 8| 8| 8| 4| 8| 8| 8| | | 7| 7| 7| 7| 7| 3| 5| 3| 3| 3| 3| 3| 3| 3| 2| 8| 8| 8| 8| 8| 8| 9| 8| 8| 8| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | CD-1 CRL MICE OUTBRED CHARLES MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| T | ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A | DMBA/DEP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L | | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | Seminiferous Tubule, Atrophy | 3 | 2 3.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Lymph Node | + + | 6 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + | 4 | Abscess | | 2 4.0| Hematopoietic Cell Proliferation | | 1 3.0| Hyperplasia | | 2 3.5| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + | 2 | Hemorrhage | | 1 3.0| Infarct | 3 | 1 3.0| __________________________________________________________________________|____________| Spleen | | 7 | Amyloid Deposition | | 2 2.0| Hematopoietic Cell Proliferation | | 7 2.7| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Other, Abscess | 4 | 1 4.0| Other, Acanthosis | 2 | 6 2.3| Other, Edema | 2 | 2 2.5| Other, Exudate | | 3 | Other, Hyperkeratosis | | 1 2.0| Other, Inflammation, Subacute | 3 | 5 3.2| Other, Ulcer | 4 | 6 3.7| Sebaceous Gland, Site of | | | Application-Mass, Hyperplasia | | 1 4.0| __________________________________________________________________________|____________| Skin, Control | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Subacute | | 1 2.0| Ulcer | | 1 2.0| __________________________________________________________________________|____________| Skin, Site of Application-No Mass | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Acanthosis | 3 3 | 6 2.7| Exudate | X X | 5 | Hyperkeratosis | 2 | 5 2.0| Hyperplasia, Focal, Mast Cell | | 1 2.0| Inflammation, Subacute | 2 3 | 4 2.8| Ulcer | 2 4 | 5 2.6| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | None | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 38 NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97 Route: SKIN APPLICATION Time: 17:20:28 __________________________________________________________________________________________________________________________________ | 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| | DAY ON TEST | 8| 8| 8| 8| 8| 9| 4| 9| 9| 9| 9| 9| 9| 9| 4| 8| 8| 8| 8| 8| 8| 4| 8| 8| 8| | | 7| 7| 7| 7| 7| 3| 5| 3| 3| 3| 3| 3| 3| 3| 2| 8| 8| 8| 8| 8| 8| 9| 8| 8| 8| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | CD-1 CRL MICE OUTBRED CHARLES MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| T | ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A | DMBA/DEP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L | | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | __________________________________________________________________________________________________________________________________ NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Spinal Cord | | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Congestion | 2 3 | 2 2.5| Hemorrhage | 3 | 3 2.3| Leukocytosis | 2 | 2 2.0| Alveolar Epithelium, Hyperplasia | | 2 2.0| Alveolus, Infiltration Cellular, | | | Histiocyte | 2 2 | 3 2.0| Interstitium, Inflammation, Chronic, | | | Focal | 3 2 2 3 2 1 2 | 11 2.1| Interstitium, Inflammation | 2 2 | 5 2.4| __________________________________________________________________________|____________| Trachea | + | 1 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Ear | | 1 | __________________________________________________________________________|____________| Eye | | 1 | Cornea, Inflammation, Chronic | | 1 3.0| _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + | 7 | Amyloid Deposition | 4 | 5 3.2| Cortex, Cyst | | 1 | Pelvis, Dilatation | 2 | 4 2.0| __________________________________________________________________________|____________| Urinary Bladder | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 39 NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97 Route: SKIN APPLICATION Time: 17:20:28 _____________________________________________________________________________________________________________________ | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| DAY ON TEST | 8| 7| 8| 0| 8| 8| 8| 8| 8| 6| 9| 6| 9| 9| 8| 9| 9| 9| 0| 9| 8| 8| 6| 8| 8| | 9| 0| 9| 9| 9| 9| 9| 9| 9| 7| 5| 9| 5| 5| 9| 5| 5| 5| 1| 5| 8| 8| 3| 8| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CD-1 CRL MICE OUTBRED CHARLES MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| ACETONE/ | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| DEP | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Liver | + + + + + + | Abscess | 4 4 | Amyloid Deposition | 2 | Clear Cell Focus | X X | Cyst | | Hematopoietic Cell Proliferation | 2 3 | Inflammation, Chronic, Focal | 3 2 2 | Necrosis | 2 4 | Vacuolization Cytoplasmic | 2 2 | __________________________________________________________________________| Mesentery | + | Necrosis | 3 | __________________________________________________________________________| Pancreas | + | Edema | 3 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + | Amyloid Deposition | 2 1 | Atrium, Thrombosis | X X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Tissue NOS | + + | Abscess | 4 | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Penis | + | __________________________________________________________________________| Preputial Gland | + + | Abscess | 4 | __________________________________________________________________________| Seminal Vesicle | + + + | Dilatation | 2 2 3 | Inflammation, Subacute | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Lymph Node | + + + +| Congestion | 4 | Hyperplasia | 4 | Iliac, Abscess | 4 | Iliac, Hyperplasia | 4 | Renal, Abscess | 4 | __________________________________________________________________________| Lymph Node, Mandibular | + + | Hyperplasia | 4 3 | __________________________________________________________________________| Lymph Node, Mesenteric | + +| _____________________________________________________________________________________________________________________| Page 40 NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97 Route: SKIN APPLICATION Time: 17:20:28 _____________________________________________________________________________________________________________________ | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| DAY ON TEST | 8| 7| 8| 0| 8| 8| 8| 8| 8| 6| 9| 6| 9| 9| 8| 9| 9| 9| 0| 9| 8| 8| 6| 8| 8| | 9| 0| 9| 9| 9| 9| 9| 9| 9| 7| 5| 9| 5| 5| 9| 5| 5| 5| 1| 5| 8| 8| 3| 8| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CD-1 CRL MICE OUTBRED CHARLES MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| ACETONE/ | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| DEP | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Hemorrhage | 4 | Hyperplasia | | Hyperplasia, Re Cell | 3| __________________________________________________________________________| Spleen | + + + + +| Amyloid Deposition | | Hematopoietic Cell Proliferation | 3 4 3 4 3| __________________________________________________________________________| Thymus | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Other, Abscess | 4 | Other, Acanthosis | 2 3 3 3 3 | Other, Edema | 2 3 | Other, Exudate | X X | Other, Hyperkeratosis | 2 2 3 | Other, Inflammation, Subacute | 3 3 2 3 4 4 | Other, Ulcer | 4 4 4 | __________________________________________________________________________| Skin, Control | + + + + + + + + + + + + + + + + + + + + + + + + +| Acanthosis | | Edema | 3 | Exudate | X | Inflammation, Subacute | 3 2 | Ulcer | 4 | __________________________________________________________________________| Skin, Site of Application-No Mass | + + + + + + + + + + + + + + + + + + + + + + + + +| Acanthosis | 1 2 2 2 2 1 | Edema | 3 | Exudate | X X X X X | Hyperkeratosis | 2 2 2 | Inflammation, Subacute | 2 2 4 | Ulcer | 1 1 4 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | 3 | Hemorrhage | 1 3 | Inflammation, Chronic, Focal | 2 | Leukocytosis | 4 | Alveolar Epithelium, Hyperplasia | 2 | _____________________________________________________________________________________________________________________| Page 41 NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97 Route: SKIN APPLICATION Time: 17:20:28 _____________________________________________________________________________________________________________________ | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| DAY ON TEST | 8| 7| 8| 0| 8| 8| 8| 8| 8| 6| 9| 6| 9| 9| 8| 9| 9| 9| 0| 9| 8| 8| 6| 8| 8| | 9| 0| 9| 9| 9| 9| 9| 9| 9| 7| 5| 9| 5| 5| 9| 5| 5| 5| 1| 5| 8| 8| 3| 8| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CD-1 CRL MICE OUTBRED CHARLES MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| ACETONE/ | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| DEP | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Alveolus, Infiltration Cellular, | | Histiocyte | 2 3 | Interstitium, Inflammation, Chronic, | | Focal | 4 1 3 2 | Interstitium, Inflammation | 2 3 3 | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + | Abscess | 4 | Amyloid Deposition | 3 3 | Hematopoietic Cell Proliferation | | Pelvis, Dilatation | | __________________________________________________________________________| Urinary Bladder | + | Inflammation, Chronic | | _____________________________________________________________________________________________________________________| Page 42 NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97 Route: SKIN APPLICATION Time: 17:20:28 __________________________________________________________________________________________________________________________________ | 3| 3| 3| 2| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 2| 3| | DAY ON TEST | 8| 8| 7| 5| 8| 9| 9| 9| 5| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 3| 7| 9| | | 9| 9| 7| 6| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 9| 4| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | CD-1 CRL MICE OUTBRED CHARLES MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| T | ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A | ACETONE/ | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L | DEP | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Liver | + + + + + | 11 | Abscess | | 2 4.0| Amyloid Deposition | 2 2 | 3 2.0| Clear Cell Focus | | 2 | Cyst | X | 1 | Hematopoietic Cell Proliferation | 4 | 3 3.0| Inflammation, Chronic, Focal | | 3 2.3| Necrosis | 4 | 3 3.3| Vacuolization Cytoplasmic | | 2 2.0| __________________________________________________________________________|____________| Mesentery | | 1 | Necrosis | | 1 3.0| __________________________________________________________________________|____________| Pancreas | | 1 | Edema | | 1 3.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + | 3 | Amyloid Deposition | 2 | 3 1.7| Atrium, Thrombosis | | 2 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Tissue NOS | + | 3 | Abscess | 4 | 2 4.0| _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Penis | | 1 | __________________________________________________________________________|____________| Preputial Gland | + + | 4 | Abscess | 3 4 | 3 3.7| __________________________________________________________________________|____________| Seminal Vesicle | + + + + + +| 9 | Dilatation | 2 4 3 3 2| 8 2.6| Inflammation, Subacute | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Lymph Node | + + + + | 8 | Congestion | | 1 4.0| Hyperplasia | 3 | 2 3.5| Iliac, Abscess | | 1 4.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 43 NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97 Route: SKIN APPLICATION Time: 17:20:28 __________________________________________________________________________________________________________________________________ | 3| 3| 3| 2| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 2| 3| | DAY ON TEST | 8| 8| 7| 5| 8| 9| 9| 9| 5| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 3| 7| 9| | | 9| 9| 7| 6| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 9| 4| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | CD-1 CRL MICE OUTBRED CHARLES MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| T | ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A | ACETONE/ | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L | DEP | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Iliac, Hyperplasia | | 1 4.0| Renal, Abscess | | 1 4.0| __________________________________________________________________________|____________| Lymph Node, Mandibular | + | 3 | Hyperplasia | 4 | 3 3.7| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + | 3 | Hemorrhage | | 1 4.0| Hyperplasia | 2 | 1 2.0| Hyperplasia, Re Cell | | 1 3.0| __________________________________________________________________________|____________| Spleen | + + + + | 9 | Amyloid Deposition | 2 | 1 2.0| Hematopoietic Cell Proliferation | 3 3 3 3 | 9 3.2| __________________________________________________________________________|____________| Thymus | + | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Other, Abscess | 4 | 2 4.0| Other, Acanthosis | 2 3 2 3 2 2 | 11 2.5| Other, Edema | | 2 2.5| Other, Exudate | X X | 4 | Other, Hyperkeratosis | 2 2 | 5 2.2| Other, Inflammation, Subacute | 3 4 3 4 4 | 11 3.4| Other, Ulcer | 2 4 2 3 4 4 | 9 3.4| __________________________________________________________________________|____________| Skin, Control | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Acanthosis | 1 | 1 1.0| Edema | | 1 3.0| Exudate | | 1 | Inflammation, Subacute | | 2 2.5| Ulcer | | 1 4.0| __________________________________________________________________________|____________| Skin, Site of Application-No Mass | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Acanthosis | 3 2 2 | 9 1.9| Edema | | 1 3.0| Exudate | X X X | 8 | Hyperkeratosis | 2 2 2 | 6 2.0| Inflammation, Subacute | 4 | 4 3.0| Ulcer | 4 2 | 5 2.4| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | None | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 44 NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97 Route: SKIN APPLICATION Time: 17:20:28 __________________________________________________________________________________________________________________________________ | 3| 3| 3| 2| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 2| 3| | DAY ON TEST | 8| 8| 7| 5| 8| 9| 9| 9| 5| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 3| 7| 9| | | 9| 9| 7| 6| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 9| 4| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | CD-1 CRL MICE OUTBRED CHARLES MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| T | ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A | ACETONE/ | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L | DEP | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Congestion | | 1 3.0| Hemorrhage | 3 | 3 2.3| Inflammation, Chronic, Focal | 2 | 2 2.0| Leukocytosis | 4 | 2 4.0| Alveolar Epithelium, Hyperplasia | 2 | 2 2.0| Alveolus, Infiltration Cellular, | | | Histiocyte | | 2 2.5| Interstitium, Inflammation, Chronic, | | | Focal | 2 2 1 2 2 | 9 2.1| Interstitium, Inflammation | 2 3 | 5 2.6| _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + | 5 | Abscess | | 1 4.0| Amyloid Deposition | 3 2 | 4 2.8| Hematopoietic Cell Proliferation | 2 | 1 2.0| Pelvis, Dilatation | 2 3 2 | 3 2.3| __________________________________________________________________________|____________| Urinary Bladder | + + | 3 | Inflammation, Chronic | 2 | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 45 NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97 Route: SKIN APPLICATION Time: 17:20:28 _____________________________________________________________________________________________________________________ | 3| 1| 3| 1| 1| 1| 1| 1| 3| 3| 3| 1| 1| 3| 1| 3| 3| 3| 1| 3| 3| 3| 1| 1| 2| DAY ON TEST | 9| 4| 9| 4| 4| 4| 4| 7| 0| 9| 3| 4| 4| 8| 4| 8| 3| 8| 4| 8| 6| 8| 4| 4| 9| | 0| 1| 0| 1| 1| 1| 1| 3| 3| 0| 7| 1| 1| 9| 1| 9| 7| 9| 1| 9| 2| 7| 1| 1| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CD-1 CRL MICE OUTBRED CHARLES MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| DMP/TPA | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Liver | + + + + | Abscess | 4 4 | Amyloid Deposition | 2 | Hematopoietic Cell Proliferation | 3 | Inflammation, Chronic, Focal | | Necrosis, Focal | 3 | Necrosis | 3 | __________________________________________________________________________| Stomach | | __________________________________________________________________________| Stomach, Forestomach | | __________________________________________________________________________| Stomach, Glandular | | __________________________________________________________________________| Tongue | +| Abscess | 4| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Tissue NOS | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Penis | + + + | Abscess | 3 4 | __________________________________________________________________________| Preputial Gland | + + | Abscess | 4 4 | __________________________________________________________________________| Testes | +| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + +| Abscess | | Hyperplasia | 3 4 | Axillary, Hematopoietic Cell | | Proliferation | | Axillary, Hyperplasia | 4 4 4 4 4 3 3 3 4 4 4| Inguinal, Hyperplasia | | Mediastinal, Hyperplasia | 3 | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + +| Abscess | | Hyperplasia | 4 4 4 4 4 4 4 4 3 4 4 4| Hyperplasia, Plasma Cell | 4 | __________________________________________________________________________| Lymph Node, Mesenteric | | Hyperplasia | | _____________________________________________________________________________________________________________________| Page 46 NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97 Route: SKIN APPLICATION Time: 17:20:28 _____________________________________________________________________________________________________________________ | 3| 1| 3| 1| 1| 1| 1| 1| 3| 3| 3| 1| 1| 3| 1| 3| 3| 3| 1| 3| 3| 3| 1| 1| 2| DAY ON TEST | 9| 4| 9| 4| 4| 4| 4| 7| 0| 9| 3| 4| 4| 8| 4| 8| 3| 8| 4| 8| 6| 8| 4| 4| 9| | 0| 1| 0| 1| 1| 1| 1| 3| 3| 0| 7| 1| 1| 9| 1| 9| 7| 9| 1| 9| 2| 7| 1| 1| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CD-1 CRL MICE OUTBRED CHARLES MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| DMP/TPA | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + +| Amyloid Deposition | 2 2 3 2 | Hematopoietic Cell Proliferation | 3 3 3 3 3 4 3 3 4 3 3 4 3 3 3 4 3 3| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Other, Abscess | | Other, Acanthosis | 3 2 3 1 2 3 2 3 2 2 2 2| Other, Exudate | X X X X X X X X| Other, Hyperkeratosis | 1 2 2 2 2 2 1 1| Other, Inflammation, Subacute | 4 4 4 2 4 3 4 3 4 4 4| Other, Ulcer | 4 4 4 4 4 4 4 3 4 4 4| Site of Application-Mass, Acanthosis,| | Focal | | __________________________________________________________________________| Skin, Control | + + + + + + + + + + + + + + + + + + + + + + + + +| Acanthosis | 2 | Exudate | X | Hyperkeratosis | 2 2 | __________________________________________________________________________| Skin, Site of Application-No Mass | + + + + + + + + + + + + + + + + + + + + + + + + +| Abscess | 4 | Acanthosis | 3 3 2 2 3 2 4 3 2 2 2 2 3 3 3 2 3 3 3 2 2 2 2 2| Exudate | X X X X X X X X X X X X X X X X X X | Hyperkeratosis | 2 2 2 1 1 3 2 1 3 3 2 2 2 2 2 2 2 2 1 2| Inflammation, Subacute | 2 4 2 4 3 2 4 4 4 4 2 3 4 2 2 3 3 4 4 2 2| Ulcer | 3 4 4 4 4 4 4 3 4 4 4 4 4 2 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Atelectasis | | Congestion | 3 3 | Hemorrhage | 2 | Leukocytosis | 2 2 | Alveolar Epithelium, Hyperplasia | 2 | Alveolus, Infiltration Cellular, | | Histiocyte | 2 2 1 | Interstitium, Inflammation, Chronic, | | Focal | 2 | Interstitium, Inflammation | 2 3 | _____________________________________________________________________________________________________________________| Page 47 NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97 Route: SKIN APPLICATION Time: 17:20:28 _____________________________________________________________________________________________________________________ | 3| 1| 3| 1| 1| 1| 1| 1| 3| 3| 3| 1| 1| 3| 1| 3| 3| 3| 1| 3| 3| 3| 1| 1| 2| DAY ON TEST | 9| 4| 9| 4| 4| 4| 4| 7| 0| 9| 3| 4| 4| 8| 4| 8| 3| 8| 4| 8| 6| 8| 4| 4| 9| | 0| 1| 0| 1| 1| 1| 1| 3| 3| 0| 7| 1| 1| 9| 1| 9| 7| 9| 1| 9| 2| 7| 1| 1| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CD-1 CRL MICE OUTBRED CHARLES MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| DMP/TPA | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | + | __________________________________________________________________________| Eye | + + | Cornea, Hyperplasia | | Cornea, Inflammation, Chronic | 3 | Lids, Cornea, Inflammation, Subacute | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + | Abscess | | Amyloid Deposition | | Cortex, Atrophy | | Cortex, Infiltration Cellular, | | Plasma Cell | 3 | Papilla, Mineralization | 2 | Papilla, Necrosis | | Pelvis, Dilatation | 2 | Proximal Convoluted Renal Tubule, | | Necrosis | | Proximal Convoluted Renal Tubule, | | Vacuolization Cytoplasmic | | __________________________________________________________________________| Urinary Bladder | + | _____________________________________________________________________________________________________________________| Page 48 NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97 Route: SKIN APPLICATION Time: 17:20:28 __________________________________________________________________________________________________________________________________ | 2| 3| 3| 3| 3| 1| 1| 2| 1| 1| 3| 2| 3| 3| 3| 1| 3| 3| 2| 3| 1| 1| 1| 1| 3| | DAY ON TEST | 9| 5| 2| 4| 4| 4| 4| 5| 4| 4| 9| 8| 3| 9| 2| 4| 9| 8| 8| 9| 4| 4| 4| 4| 9| | | 9| 7| 0| 2| 8| 2| 2| 6| 2| 2| 3| 4| 4| 3| 5| 2| 4| 3| 4| 4| 2| 2| 2| 2| 4| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | CD-1 CRL MICE OUTBRED CHARLES MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| T | ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A | DMP/TPA | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L | | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Liver | + + + + + + | 10 | Abscess | 4 | 3 4.0| Amyloid Deposition | 2 3 | 3 2.3| Hematopoietic Cell Proliferation | 2 | 2 2.5| Inflammation, Chronic, Focal | 2 2 | 2 2.0| Necrosis, Focal | | 1 3.0| Necrosis | 4 | 2 3.5| __________________________________________________________________________|____________| Stomach | + | 1 | __________________________________________________________________________|____________| Stomach, Forestomach | + | 1 | __________________________________________________________________________|____________| Stomach, Glandular | + | 1 | __________________________________________________________________________|____________| Tongue | | 1 | Abscess | | 1 4.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Tissue NOS | + + | 2 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Penis | | 3 | Abscess | | 2 3.5| __________________________________________________________________________|____________| Preputial Gland | | 2 | Abscess | | 2 4.0| __________________________________________________________________________|____________| Testes | | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + | 29 | Abscess | 4 | 1 4.0| Hyperplasia | 4 4 4 | 5 3.8| Axillary, Hematopoietic Cell | | | Proliferation | 3 | 1 3.0| Axillary, Hyperplasia | 3 4 4 4 4 4 4 4 4 4 | 21 3.8| Inguinal, Hyperplasia | 3 3 | 2 3.0| Mediastinal, Hyperplasia | | 1 3.0| __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + | 22 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 49 NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97 Route: SKIN APPLICATION Time: 17:20:28 __________________________________________________________________________________________________________________________________ | 2| 3| 3| 3| 3| 1| 1| 2| 1| 1| 3| 2| 3| 3| 3| 1| 3| 3| 2| 3| 1| 1| 1| 1| 3| | DAY ON TEST | 9| 5| 2| 4| 4| 4| 4| 5| 4| 4| 9| 8| 3| 9| 2| 4| 9| 8| 8| 9| 4| 4| 4| 4| 9| | | 9| 7| 0| 2| 8| 2| 2| 6| 2| 2| 3| 4| 4| 3| 5| 2| 4| 3| 4| 4| 2| 2| 2| 2| 4| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | CD-1 CRL MICE OUTBRED CHARLES MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| T | ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A | DMP/TPA | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L | | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Abscess | 4 4 4 | 3 4.0| Hyperplasia | 4 4 4 3 4 3 3 4 4 4 | 22 3.8| Hyperplasia, Plasma Cell | | 1 4.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + | 1 | Hyperplasia | 2 | 1 2.0| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + | 34 | Amyloid Deposition | 1 2 3 3 2 | 9 2.2| Hematopoietic Cell Proliferation | 3 4 4 3 4 3 4 3 3 3 4 3 3 3 3 | 33 3.3| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Other, Abscess | 4 4 | 2 4.0| Other, Acanthosis | 3 3 3 2 3 3 2 3 2 | 21 2.4| Other, Exudate | X X X X X | 13 | Other, Hyperkeratosis | 1 2 3 | 11 1.7| Other, Inflammation, Subacute | 4 4 4 4 4 2 4 4 | 19 3.7| Other, Ulcer | 4 4 4 4 3 4 3 4 4 | 20 3.9| Site of Application-Mass, Acanthosis,| | | Focal | 4 | 1 4.0| __________________________________________________________________________|____________| Skin, Control | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Acanthosis | | 1 2.0| Exudate | | 1 | Hyperkeratosis | | 2 2.0| __________________________________________________________________________|____________| Skin, Site of Application-No Mass | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Abscess | 2 | 2 3.0| Acanthosis | 2 2 2 1 2 3 1 2 2 2 2 2 2 2 2 3 3 2 3 3 2 2 2| 47 2.3| Exudate | X X X X X X X X X X X X | 30 | Hyperkeratosis | 1 2 2 2 3 2 2 2 1 2 2 2 3 2 | 35 2.0| Inflammation, Subacute | 3 2 2 4 3 2 2 4 4 3 3 4 2 4 2 2 4 | 38 3.0| Ulcer | 3 4 4 2 2 4 4 4 3 4 4 4 4 | 27 3.6| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + | 2 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 50 NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97 Route: SKIN APPLICATION Time: 17:20:28 __________________________________________________________________________________________________________________________________ | 2| 3| 3| 3| 3| 1| 1| 2| 1| 1| 3| 2| 3| 3| 3| 1| 3| 3| 2| 3| 1| 1| 1| 1| 3| | DAY ON TEST | 9| 5| 2| 4| 4| 4| 4| 5| 4| 4| 9| 8| 3| 9| 2| 4| 9| 8| 8| 9| 4| 4| 4| 4| 9| | | 9| 7| 0| 2| 8| 2| 2| 6| 2| 2| 3| 4| 4| 3| 5| 2| 4| 3| 4| 4| 2| 2| 2| 2| 4| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | CD-1 CRL MICE OUTBRED CHARLES MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| T | ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A | DMP/TPA | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L | | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | Atelectasis | 4 | 1 4.0| Congestion | | 2 3.0| Hemorrhage | | 1 2.0| Leukocytosis | 2 2 3 | 5 2.2| Alveolar Epithelium, Hyperplasia | 3 | 2 2.5| Alveolus, Infiltration Cellular, | | | Histiocyte | | 3 1.7| Interstitium, Inflammation, Chronic, | | | Focal | | 1 2.0| Interstitium, Inflammation | | 2 2.5| _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Ear | | 1 | __________________________________________________________________________|____________| Eye | + + + | 5 | Cornea, Hyperplasia | 3 | 1 3.0| Cornea, Inflammation, Chronic | 3 | 2 3.0| Lids, Cornea, Inflammation, Subacute | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + | 4 | Abscess | 3 | 1 3.0| Amyloid Deposition | 2 2 | 2 2.0| Cortex, Atrophy | 4 | 1 4.0| Cortex, Infiltration Cellular, | | | Plasma Cell | | 1 3.0| Papilla, Mineralization | | 1 2.0| Papilla, Necrosis | 3 | 1 3.0| Pelvis, Dilatation | | 1 2.0| Proximal Convoluted Renal Tubule, | | | Necrosis | 3 | 1 3.0| Proximal Convoluted Renal Tubule, | | | Vacuolization Cytoplasmic | 2 | 1 2.0| __________________________________________________________________________|____________| Urinary Bladder | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 51 NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97 Route: SKIN APPLICATION Time: 17:20:28 _____________________________________________________________________________________________________________________ | 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| DAY ON TEST | 9| 9| 8| 9| 9| 9| 9| 8| 5| 9| 9| 9| 8| 9| 9| 9| 3| 9| 7| 9| 8| 8| 8| 8| 8| | 0| 0| 8| 0| 0| 0| 0| 9| 7| 0| 0| 0| 3| 0| 0| 0| 2| 0| 9| 0| 8| 8| 8| 8| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CD-1 CRL MICE OUTBRED CHARLES MALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| DMP/ACET | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| ONE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Liver | + + + + + + | Abscess | 4 | Amyloid Deposition | 1 2 2 | Hematopoietic Cell Proliferation | 4 3 | Inflammation, Chronic, Focal | 2 | Necrosis | 2 | __________________________________________________________________________| Pancreas | + | __________________________________________________________________________| Stomach | + | __________________________________________________________________________| Stomach, Glandular | + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + | Amyloid Deposition | 3 | Atrium, Thrombosis | X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Pituitary Gland | + | Cyst | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Tissue NOS | + +| _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Penis | + | Edema | | __________________________________________________________________________| Preputial Gland | + + | Abscess | 4 | Dilatation | 3 | __________________________________________________________________________| Seminal Vesicle | M + + +| Dilatation | 2 3 3| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Lymph Node | + + + + + | Hyperplasia | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + | Cyst | | Hyperplasia | 4 3 4 3 | __________________________________________________________________________| Lymph Node, Mesenteric | + | Hematopoietic Cell Proliferation | 3 | Hemorrhage | 3 | __________________________________________________________________________| Spleen | + + + + + | Amyloid Deposition | | Congestion | 3 | Hematopoietic Cell Proliferation | 3 3 3 4 3 | _____________________________________________________________________________________________________________________| Page 52 NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97 Route: SKIN APPLICATION Time: 17:20:28 _____________________________________________________________________________________________________________________ | 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| DAY ON TEST | 9| 9| 8| 9| 9| 9| 9| 8| 5| 9| 9| 9| 8| 9| 9| 9| 3| 9| 7| 9| 8| 8| 8| 8| 8| | 0| 0| 8| 0| 0| 0| 0| 9| 7| 0| 0| 0| 3| 0| 0| 0| 2| 0| 9| 0| 8| 8| 8| 8| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CD-1 CRL MICE OUTBRED CHARLES MALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| DMP/ACET | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| ONE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Other, Abscess | 4 | Other, Acanthosis | 3 2 3 3 2 2 3 | Other, Edema | 3 3 | Other, Exudate | X X X X X | Other, Hyperkeratosis | 2 2 3 | Other, Inflammation, Subacute | 3 3 4 3 4 | Other, Ulcer | 3 3 3 4 3 3 4 | __________________________________________________________________________| Skin, Control | + + + + + + + + + + + + + + + + + + + + + + + + +| Edema | 2 | Inflammation, Subacute | | __________________________________________________________________________| Skin, Site of Application-No Mass | + + + + + + + + + + + + + + + + + + + + + + + + +| Acanthosis | 2 3 2 1 2 3 | Exudate | X X X | Hyperkeratosis | 3 | Inflammation, Subacute | 2 | Ulcer | 2 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Abscess | | Congestion | 2 | Fibrosis, Focal | | Foreign Body | 3 | Hemorrhage | 3 2 | Leukocytosis | 3 | Alveolar Epithelium, Hyperplasia | 2 | Alveolus, Infiltration Cellular, | | Histiocyte | 1 2 | Interstitium, Inflammation, Chronic, | | Focal | 1 1 2 1 3 2 1 | Interstitium, Inflammation | 2 2 2 3 | Pleura, Inflammation, Suppurative | | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | + + | _____________________________________________________________________________________________________________________| Page 53 NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97 Route: SKIN APPLICATION Time: 17:20:28 _____________________________________________________________________________________________________________________ | 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| DAY ON TEST | 9| 9| 8| 9| 9| 9| 9| 8| 5| 9| 9| 9| 8| 9| 9| 9| 3| 9| 7| 9| 8| 8| 8| 8| 8| | 0| 0| 8| 0| 0| 0| 0| 9| 7| 0| 0| 0| 3| 0| 0| 0| 2| 0| 9| 0| 8| 8| 8| 8| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CD-1 CRL MICE OUTBRED CHARLES MALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| DMP/ACET | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| ONE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM - cont | | | | __________________________________________________________________________| Eye | + + | Cornea, Inflammation, Chronic | 3 | Cornea, Inflammation, Subacute | 3 | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + | Abscess | 4 | Amyloid Deposition | 3 3 4 3 | Pelvis, Dilatation | 3 2 | __________________________________________________________________________| Urinary Bladder | +| Calculus Micro Observation Only | X| Congestion | | _____________________________________________________________________________________________________________________| Page 54 NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97 Route: SKIN APPLICATION Time: 17:20:28 __________________________________________________________________________________________________________________________________ | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | DAY ON TEST | 8| 8| 5| 6| 8| 8| 8| 8| 8| 8| 8| 8| 7| 6| 8| 9| 9| 9| 9| 9| 9| 9| 5| 9| 9| | | 8| 8| 5| 3| 8| 9| 9| 9| 9| 9| 9| 9| 1| 0| 9| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | CD-1 CRL MICE OUTBRED CHARLES MALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| T | ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A | DMP/ACET | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L | ONE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Liver | + + + + + + + + | 14 | Abscess | | 1 4.0| Amyloid Deposition | 2 1 | 5 1.6| Hematopoietic Cell Proliferation | 4 | 3 3.7| Inflammation, Chronic, Focal | 1 2 2 2 2 | 6 1.8| Necrosis | | 1 2.0| __________________________________________________________________________|____________| Pancreas | | 1 | __________________________________________________________________________|____________| Stomach | | 1 | __________________________________________________________________________|____________| Stomach, Glandular | | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | | 1 | Amyloid Deposition | | 1 3.0| Atrium, Thrombosis | | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Pituitary Gland | | 1 | Cyst | | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Tissue NOS | + + | 4 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Penis | + | 2 | Edema | 3 | 1 3.0| __________________________________________________________________________|____________| Preputial Gland | | 2 | Abscess | | 1 4.0| Dilatation | | 1 3.0| __________________________________________________________________________|____________| Seminal Vesicle | + + + + | 7 | Dilatation | 3 2 2 | 6 2.5| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Lymph Node | + + + | 8 | Hyperplasia | 2 3 | 2 2.5| __________________________________________________________________________|____________| Lymph Node, Mandibular | + | 6 | Cyst | X | 1 | Hyperplasia | 3 | 5 3.4| __________________________________________________________________________|____________| Lymph Node, Mesenteric | | 1 | Hematopoietic Cell Proliferation | | 1 3.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 55 NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97 Route: SKIN APPLICATION Time: 17:20:28 __________________________________________________________________________________________________________________________________ | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | DAY ON TEST | 8| 8| 5| 6| 8| 8| 8| 8| 8| 8| 8| 8| 7| 6| 8| 9| 9| 9| 9| 9| 9| 9| 5| 9| 9| | | 8| 8| 5| 3| 8| 9| 9| 9| 9| 9| 9| 9| 1| 0| 9| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | CD-1 CRL MICE OUTBRED CHARLES MALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| T | ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A | DMP/ACET | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L | ONE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Hemorrhage | | 1 3.0| __________________________________________________________________________|____________| Spleen | A + + | 7 | Amyloid Deposition | 2 | 1 2.0| Congestion | | 1 3.0| Hematopoietic Cell Proliferation | 4 3 | 7 3.3| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Other, Abscess | 4 | 2 4.0| Other, Acanthosis | 3 3 2 2 | 11 2.5| Other, Edema | 3 3 | 4 3.0| Other, Exudate | X X X X | 9 | Other, Hyperkeratosis | 2 | 4 2.3| Other, Inflammation, Subacute | 2 4 3 | 8 3.3| Other, Ulcer | 3 4 3 4 2 | 12 3.3| __________________________________________________________________________|____________| Skin, Control | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Edema | | 1 2.0| Inflammation, Subacute | 2 2 | 2 2.0| __________________________________________________________________________|____________| Skin, Site of Application-No Mass | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Acanthosis | 1 2 2 | 9 2.0| Exudate | X X | 5 | Hyperkeratosis | | 1 3.0| Inflammation, Subacute | 2 2 | 3 2.0| Ulcer | 2 2 | 3 2.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Abscess | 4 | 1 4.0| Congestion | 2 2 2 | 4 2.0| Fibrosis, Focal | 2 | 1 2.0| Foreign Body | | 1 3.0| Hemorrhage | 2 | 3 2.3| Leukocytosis | 3 | 2 3.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 56 NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97 Route: SKIN APPLICATION Time: 17:20:28 __________________________________________________________________________________________________________________________________ | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | DAY ON TEST | 8| 8| 5| 6| 8| 8| 8| 8| 8| 8| 8| 8| 7| 6| 8| 9| 9| 9| 9| 9| 9| 9| 5| 9| 9| | | 8| 8| 5| 3| 8| 9| 9| 9| 9| 9| 9| 9| 1| 0| 9| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | CD-1 CRL MICE OUTBRED CHARLES MALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| T | ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A | DMP/ACET | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L | ONE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | Alveolar Epithelium, Hyperplasia | | 1 2.0| Alveolus, Infiltration Cellular, | | | Histiocyte | 2 2 | 4 1.8| Interstitium, Inflammation, Chronic, | | | Focal | 1 | 8 1.5| Interstitium, Inflammation | | 4 2.3| Pleura, Inflammation, Suppurative | 4 | 1 4.0| _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Ear | + + + | 5 | __________________________________________________________________________|____________| Eye | | 2 | Cornea, Inflammation, Chronic | | 1 3.0| Cornea, Inflammation, Subacute | | 1 3.0| _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + | 8 | Abscess | | 1 4.0| Amyloid Deposition | 2 | 5 3.0| Pelvis, Dilatation | 2 1 | 4 2.0| __________________________________________________________________________|____________| Urinary Bladder | + A + | 3 | Calculus Micro Observation Only | | 1 | Congestion | 2 | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 57 NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97 Route: SKIN APPLICATION Time: 17:20:28 _____________________________________________________________________________________________________________________ | 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| DAY ON TEST | 8| 6| 8| 7| 8| 3| 8| 8| 8| 8| 9| 4| 9| 9| 9| 9| 9| 9| 9| 9| 8| 8| 8| 8| 5| | 7| 1| 7| 5| 7| 4| 7| 7| 7| 7| 4| 4| 4| 4| 4| 4| 4| 4| 2| 4| 7| 7| 7| 4| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CD-1 CRL MICE OUTBRED CHARLES MALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| DMBA/DMP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Intestine Large | | __________________________________________________________________________| Intestine Large, Cecum | | Edema | | Inflammation, Chronic | | Necrosis | | __________________________________________________________________________| Intestine Small | + | __________________________________________________________________________| Intestine Small, Duodenum | | Amyloid Deposition | | __________________________________________________________________________| Intestine Small, Ileum | | Amyloid Deposition | | __________________________________________________________________________| Intestine Small, Jejunum | A | Amyloid Deposition | | __________________________________________________________________________| Liver | + + + + + | Abscess | 4 | Amyloid Deposition | 2 | Clear Cell Focus, Multiple | 4 | Cytomegaly | 3 | Inflammation, Chronic, Focal | 3 2 2 | __________________________________________________________________________| Pancreas | + | Edema | 3 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + | Amyloid Deposition | 2 3 | Atrium, Thrombosis | X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Thyroid Gland | + | Amyloid Deposition | 4 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Tissue NOS | + + + + | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Penis | | __________________________________________________________________________| Preputial Gland | | Abscess | | Dilatation | | __________________________________________________________________________| Prostate | +| Hemorrhage | 4| __________________________________________________________________________| Seminal Vesicle | + | Dilatation | 3 | __________________________________________________________________________| Testes | + | Amyloid Deposition | 3 | _____________________________________________________________________________________________________________________| Page 58 NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97 Route: SKIN APPLICATION Time: 17:20:28 _____________________________________________________________________________________________________________________ | 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| DAY ON TEST | 8| 6| 8| 7| 8| 3| 8| 8| 8| 8| 9| 4| 9| 9| 9| 9| 9| 9| 9| 9| 8| 8| 8| 8| 5| | 7| 1| 7| 5| 7| 4| 7| 7| 7| 7| 4| 4| 4| 4| 4| 4| 4| 4| 2| 4| 7| 7| 7| 4| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CD-1 CRL MICE OUTBRED CHARLES MALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| DMBA/DMP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | Seminiferous Tubule, Atrophy | 4 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Lymph Node | | Hematopoietic Cell Proliferation | | Axillary, Hyperplasia | | Pancreatic, Hematopoietic Cell | | Proliferation | | __________________________________________________________________________| Lymph Node, Mandibular | | Cyst | | Hyperplasia | | __________________________________________________________________________| Lymph Node, Mesenteric | | Cyst | | __________________________________________________________________________| Spleen | + + | Hematopoietic Cell Proliferation | 3 3 | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Other, Acanthosis | 2 | Other, Edema | 3 2 3 2 | Other, Exudate | X | Other, Hyperkeratosis | | Other, Inflammation, Subacute | 2 | Other, Ulcer | | __________________________________________________________________________| Skin, Control | + + + + + + + + + + + + + + + + + + + + + + + + +| Edema | 2 3 2 | Ulcer | 2 | __________________________________________________________________________| Skin, Site of Application-No Mass | + + + + + + + + + + + + + + + + + + + + + + + + +| Acanthosis | 1 1 1 2 2 | Edema | | Exudate | X | Hyperkeratosis | | Inflammation, Subacute | 2 | Ulcer | 3 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Atelectasis | | _____________________________________________________________________________________________________________________| Page 59 NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97 Route: SKIN APPLICATION Time: 17:20:28 _____________________________________________________________________________________________________________________ | 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| DAY ON TEST | 8| 6| 8| 7| 8| 3| 8| 8| 8| 8| 9| 4| 9| 9| 9| 9| 9| 9| 9| 9| 8| 8| 8| 8| 5| | 7| 1| 7| 5| 7| 4| 7| 7| 7| 7| 4| 4| 4| 4| 4| 4| 4| 4| 2| 4| 7| 7| 7| 4| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CD-1 CRL MICE OUTBRED CHARLES MALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| DMBA/DMP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Congestion | 2 3 3 | Fibrosis, Focal | | Hemorrhage | 3 2 2 2 2 2 | Alveolar Epithelium, Hyperplasia | 2 | Alveolus, Infiltration Cellular, | | Histiocyte | 3 3 2 2 | Interstitium, Inflammation, Chronic, | | Focal | 2 4 1 2 2 | Interstitium, Inflammation | 2 3 2 2 2 3 | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + | Amyloid Deposition | 3 4 4 3 3 | Infarct | 3 | Nephropathy | 2 | Cortex, Cyst | X X | Pelvis, Dilatation | 2 3 3 | __________________________________________________________________________| Urethra | | __________________________________________________________________________| Urinary Bladder | + | Hemorrhage | 4 | _____________________________________________________________________________________________________________________| Page 60 NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97 Route: SKIN APPLICATION Time: 17:20:28 __________________________________________________________________________________________________________________________________ | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 1| 3| 3| | DAY ON TEST | 8| 8| 8| 8| 8| 9| 8| 3| 8| 9| 9| 9| 6| 9| 9| 9| 9| 2| 9| 9| 9| 9| 4| 9| 9| | | 8| 8| 7| 8| 8| 5| 9| 0| 2| 5| 5| 5| 9| 5| 5| 5| 5| 7| 5| 5| 5| 5| 2| 5| 5| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | CD-1 CRL MICE OUTBRED CHARLES MALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| T | ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A | DMBA/DMP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L | | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Intestine Large | + + | 2 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + | 2 | Edema | 3 3 | 2 3.0| Inflammation, Chronic | 3 | 1 3.0| Necrosis | 3 | 1 3.0| __________________________________________________________________________|____________| Intestine Small | + + + | 4 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + | 1 | Amyloid Deposition | 1 | 1 1.0| __________________________________________________________________________|____________| Intestine Small, Ileum | + + + | 3 | Amyloid Deposition | 4 4 | 2 4.0| __________________________________________________________________________|____________| Intestine Small, Jejunum | + + | 2 | Amyloid Deposition | 3 | 1 3.0| __________________________________________________________________________|____________| Liver | +| 6 | Abscess | | 1 4.0| Amyloid Deposition | | 1 2.0| Clear Cell Focus, Multiple | | 1 4.0| Cytomegaly | | 1 3.0| Inflammation, Chronic, Focal | 1| 4 2.0| __________________________________________________________________________|____________| Pancreas | + + | 3 | Edema | 3 2 | 3 2.7| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + | 3 | Amyloid Deposition | 2 | 3 2.3| Atrium, Thrombosis | X | 2 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Thyroid Gland | | 1 | Amyloid Deposition | | 1 4.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Tissue NOS | | 4 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Penis | + | 1 | __________________________________________________________________________|____________| Preputial Gland | + | 1 | Abscess | 3 | 1 3.0| Dilatation | 2 | 1 2.0| __________________________________________________________________________|____________| Prostate | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 61 NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97 Route: SKIN APPLICATION Time: 17:20:28 __________________________________________________________________________________________________________________________________ | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 1| 3| 3| | DAY ON TEST | 8| 8| 8| 8| 8| 9| 8| 3| 8| 9| 9| 9| 6| 9| 9| 9| 9| 2| 9| 9| 9| 9| 4| 9| 9| | | 8| 8| 7| 8| 8| 5| 9| 0| 2| 5| 5| 5| 9| 5| 5| 5| 5| 7| 5| 5| 5| 5| 2| 5| 5| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | CD-1 CRL MICE OUTBRED CHARLES MALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| T | ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A | DMBA/DMP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L | | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | Hemorrhage | | 1 4.0| __________________________________________________________________________|____________| Seminal Vesicle | + + | 3 | Dilatation | 2 2 | 3 2.3| __________________________________________________________________________|____________| Testes | | 1 | Amyloid Deposition | | 1 3.0| Seminiferous Tubule, Atrophy | | 1 4.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Lymph Node | + + | 2 | Hematopoietic Cell Proliferation | 4 | 1 4.0| Axillary, Hyperplasia | 4 | 1 4.0| Pancreatic, Hematopoietic Cell | | | Proliferation | 4 | 1 4.0| __________________________________________________________________________|____________| Lymph Node, Mandibular | + | 1 | Cyst | X | 1 | Hyperplasia | 4 | 1 4.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + | 1 | Cyst | X | 1 | __________________________________________________________________________|____________| Spleen | + + | 4 | Hematopoietic Cell Proliferation | 3 3 | 4 3.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Other, Acanthosis | 2 3 3 | 4 2.5| Other, Edema | 3 | 5 2.6| Other, Exudate | X X X | 4 | Other, Hyperkeratosis | 2 | 1 2.0| Other, Inflammation, Subacute | 3 4 4 | 4 3.3| Other, Ulcer | 3 4 4 | 3 3.7| __________________________________________________________________________|____________| Skin, Control | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Edema | | 3 2.3| Ulcer | | 1 2.0| __________________________________________________________________________|____________| Skin, Site of Application-No Mass | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Acanthosis | 2 3 | 7 1.7| Edema | 3 | 1 3.0| Exudate | X | 2 | Hyperkeratosis | 1 1 | 2 1.0| Inflammation, Subacute | 1 2 | 3 1.7| Ulcer | 2 2 | 3 2.3| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 62 NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97 Route: SKIN APPLICATION Time: 17:20:28 __________________________________________________________________________________________________________________________________ | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 1| 3| 3| | DAY ON TEST | 8| 8| 8| 8| 8| 9| 8| 3| 8| 9| 9| 9| 6| 9| 9| 9| 9| 2| 9| 9| 9| 9| 4| 9| 9| | | 8| 8| 7| 8| 8| 5| 9| 0| 2| 5| 5| 5| 9| 5| 5| 5| 5| 7| 5| 5| 5| 5| 2| 5| 5| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | CD-1 CRL MICE OUTBRED CHARLES MALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| T | ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A | DMBA/DMP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L | | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | __________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atelectasis | 4 | 1 4.0| Congestion | 2 3 2 | 6 2.5| Fibrosis, Focal | 2 | 1 2.0| Hemorrhage | 2 2 2 | 9 2.1| Alveolar Epithelium, Hyperplasia | | 1 2.0| Alveolus, Infiltration Cellular, | | | Histiocyte | 3 | 5 2.6| Interstitium, Inflammation, Chronic, | | | Focal | 3 1 | 7 2.1| Interstitium, Inflammation | 2 2 2 2 3| 11 2.3| _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + | 10 | Amyloid Deposition | 3 3 | 7 3.3| Infarct | | 1 3.0| Nephropathy | | 1 2.0| Cortex, Cyst | X | 3 | Pelvis, Dilatation | 2 | 4 2.5| __________________________________________________________________________|____________| Urethra | + | 1 | __________________________________________________________________________|____________| Urinary Bladder | + | 2 | Hemorrhage | | 1 4.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 63 NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97 Route: SKIN APPLICATION Time: 17:20:28 _____________________________________________________________________________________________________________________ | 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| DAY ON TEST | 1| 8| 8| 8| 6| 8| 8| 8| 8| 8| 9| 9| 8| 9| 9| 9| 9| 9| 9| 9| 8| 8| 8| 8| 8| | 7| 4| 8| 8| 6| 8| 8| 8| 8| 8| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 7| 7| 7| 7| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CD-1 CRL MICE OUTBRED CHARLES MALE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| ACETONE/ | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| DMP | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + A + + + + + + + M M + + + + + + + + + + +| Inflammation, Chronic | | __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + A + + + + + + + + + + + + + + + + + + + +| Amyloid Deposition | 2 1 | Edema | | __________________________________________________________________________| Intestine Large, Colon | + + + A + + + + + + + + + + + + + + + + + + + +| Edema | | __________________________________________________________________________| Intestine Large, Rectum | + + + A + + + + + + + + + + + + + + + M + + + +| __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + +| Cortex, Amyloid Deposition | | __________________________________________________________________________| Intestine Small, Duodenum | + + + A + + + + + + + + + + + + + + + + + + + +| Amyloid Deposition | 1 2 1 1 1 1 2 2 | __________________________________________________________________________| Intestine Small, Ileum | + + + A + + + + + + + + + + + + + + + + + + + +| Amyloid Deposition | 3 3 4 4 4 3 4 4 4 4 4 4 | Hemorrhage | | __________________________________________________________________________| Intestine Small, Jejunum | + + + A + + + + + + + + + + + + + + + + + + + +| Amyloid Deposition | 2 3 2 2 2 2 3 3 | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + +| Amyloid Deposition | 2 3 2 2 2 2 2 | Basophilic Focus | X | Hematopoietic Cell Proliferation | | Hyperplasia | 3 | Inflammation, Chronic, Focal | 2 2 2 2 2 1 2 2 2 2 2 2 | Karyomegaly | | Necrosis | 2 | Vacuolization Cytoplasmic | 2 | Vacuolization Nuclear | 3 3 | Hepatocyte, Hyperplasia | 2 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + +| Edema | 2 2 2 2 | Inflammation, Subacute | | __________________________________________________________________________| Salivary Glands | + M + + + + + + + + + + + + + + + + + + + + + +| Amyloid Deposition | 2 2 3 3 2 2 3 2 | __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + +| Mucosa, Hyperplasia, Glandular | | Mucosa, Hyperplasia | 3 | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +| Amyloid Deposition | 2 2 2 | Inflammation, Chronic | 2 | Mucosa, Dilatation | 2 | Mucosa, Hyperplasia | 3 | _____________________________________________________________________________________________________________________| Page 64 NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97 Route: SKIN APPLICATION Time: 17:20:28 _____________________________________________________________________________________________________________________ | 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| DAY ON TEST | 1| 8| 8| 8| 6| 8| 8| 8| 8| 8| 9| 9| 8| 9| 9| 9| 9| 9| 9| 9| 8| 8| 8| 8| 8| | 7| 4| 8| 8| 6| 8| 8| 8| 8| 8| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 7| 7| 7| 7| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CD-1 CRL MICE OUTBRED CHARLES MALE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| ACETONE/ | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| DMP | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + +| Abscess | 2 | Amyloid Deposition | 1 3 1 2 3 3 2 2 1 2 2 | Inflammation, Chronic, Focal | 1| Atrium, Thrombosis | X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + +| Adrenal Gland, Amyloid Deposition | 4 | Capsule, Hyperplasia | 2 1 2 2 2 2 2 2 2| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + +| Amyloid Deposition | 3 2 3 3 4 2 3 4 | Hyperplasia, Focal | 2 | Hypertrophy, Focal | | Pigmentation | 2 2 2 2 2 2 3 3 2 1 2 2 2 3 | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | M M + M + + + + + + + + + + + + + M M + + M + +| Amyloid Deposition | 2 2 2 1 | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Cyst | X | Pars Distalis, Hyperplasia, Focal | | Pars Distalis, Hyperplasia | 1 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +| Amyloid Deposition | 2 3 1 2 3 2 2 2 2 1 | Follicle, Dilatation | 2 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Tissue NOS | + + | Abscess | 4 4 | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + +| Spermatocele | | __________________________________________________________________________| Penis | | Inflammation, Suppurative | | __________________________________________________________________________| Preputial Gland | + | Abscess | 4 | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + +| Abscess | 3 | Inflammation, Chronic | 2 | Inflammation | 2 | _____________________________________________________________________________________________________________________| Page 65 NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97 Route: SKIN APPLICATION Time: 17:20:28 _____________________________________________________________________________________________________________________ | 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| DAY ON TEST | 1| 8| 8| 8| 6| 8| 8| 8| 8| 8| 9| 9| 8| 9| 9| 9| 9| 9| 9| 9| 8| 8| 8| 8| 8| | 7| 4| 8| 8| 6| 8| 8| 8| 8| 8| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 7| 7| 7| 7| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CD-1 CRL MICE OUTBRED CHARLES MALE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| ACETONE/ | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| DMP | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + +| Dilatation | 2 2 1 4 | Inflammation | | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + +| Amyloid Deposition | 4 4 2 3 2 1 | Fibrosis | | Inflammation, Chronic | | Interstitial Cell, Hyperplasia | 2 3 2 | Seminiferous Tubule, Degeneration | 4 3 4 3 3 2 3 2 1 1 | Seminiferous Tubule, Giant Cell | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + M + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 3 | Axillary, Hyperplasia | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + M + + + + + + + + +| Amyloid Deposition | | Cyst | X | Hematopoietic Cell Proliferation | 2 | Hyperplasia | 4 3 3 | __________________________________________________________________________| Lymph Node, Mesenteric | + + + A + + + + + + + + + + + + + + + + + + + +| Abscess | | Amyloid Deposition | 2 3 2 2 2 2 2 | Hematopoietic Cell Proliferation | | Hyperplasia | 3 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + +| Amyloid Deposition | 2 2 | Hematopoietic Cell Proliferation | 3 3 2 3 2 2 1 4 2 2 2 3 2 3 2 2 1 2 2 2 2 2 2 2| Pigmentation, Hemosiderin | | __________________________________________________________________________| Thymus | + + + M + + + + + + + + + + + + + + + I + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M M M + + M + M M M M M M M M M M M M + M M +| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + +| Other, Abscess | 4 4 | Other, Acanthosis | 3 2 2 | Other, Edema | | Other, Exudate | X X X | Other, Hyperkeratosis | | Other, Inflammation, Subacute | 4 4 2 4 | Other, Ulcer | 4 4 1 4 | Site of Application-Mass, Acanthosis,| | Focal | 4 | _____________________________________________________________________________________________________________________| Page 66 NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97 Route: SKIN APPLICATION Time: 17:20:28 _____________________________________________________________________________________________________________________ | 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| DAY ON TEST | 1| 8| 8| 8| 6| 8| 8| 8| 8| 8| 9| 9| 8| 9| 9| 9| 9| 9| 9| 9| 8| 8| 8| 8| 8| | 7| 4| 8| 8| 6| 8| 8| 8| 8| 8| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 7| 7| 7| 7| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CD-1 CRL MICE OUTBRED CHARLES MALE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| ACETONE/ | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| DMP | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | __________________________________________________________________________| Skin, Control | + + + + + + + + + + + + + + + + + + + + + + + +| Acanthosis | | Inflammation, Subacute | | __________________________________________________________________________| Skin, Site of Application-No Mass | + + + + + + + + + + + + + + + + + + + + + + + +| Acanthosis | 2 1 2 2 2 1 2| Exudate | X X X X| Hyperkeratosis | 2 2 2| Inflammation, Subacute | 2 2 2 2 1 2| Ulcer | 2 2 2| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + M + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + +| Thalamus, Mineralization, Focal | 1 | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + +| Amyloid Deposition | | Congestion | 2 | Alveolar Epithelium, Hyperplasia | 2 2| Alveolus, Infiltration Cellular, | | Histiocyte | 2 3 2 | Interstitium, Inflammation, Chronic, | | Focal | 2 2 1 2 3 | Interstitium, Inflammation | 3 2 3 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | 2 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | | __________________________________________________________________________| Eye | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + +| Abscess | | Amyloid Deposition | 2 4 3 3 3 4 3 2 2 4 | Infarct | 3 | Nephropathy | 2 2 1 2 2 2 1| Cortex, Cyst | X X | Pelvis, Dilatation | 2 2 2 2 3 2 | __________________________________________________________________________| Urinary Bladder | + M + A + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 67 NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97 Route: SKIN APPLICATION Time: 17:20:28 _____________________________________________________________________________________________________________________ | 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| DAY ON TEST | 1| 8| 8| 8| 6| 8| 8| 8| 8| 8| 9| 9| 8| 9| 9| 9| 9| 9| 9| 9| 8| 8| 8| 8| 8| | 7| 4| 8| 8| 6| 8| 8| 8| 8| 8| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 7| 7| 7| 7| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CD-1 CRL MICE OUTBRED CHARLES MALE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| ACETONE/ | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| DMP | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| URINARY SYSTEM - cont | | | | Calculus Micro Observation Only | X X X | Inflammation | | Mucosa, Hyperplasia | | _____________________________________________________________________________________________________________________| Page 68 NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97 Route: SKIN APPLICATION Time: 17:20:28 __________________________________________________________________________________________________________________________________ | 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | DAY ON TEST | 8| 8| 4| 8| 8| 8| 8| 8| 8| 1| 8| 8| 8| 8| 8| 9| 5| 9| 9| 9| 9| 9| 9| 9| 8| | | 7| 7| 1| 7| 0| 7| 7| 7| 7| 8| 7| 7| 7| 7| 7| 4| 4| 4| 0| 4| 4| 4| 4| 4| 9| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | CD-1 CRL MICE OUTBRED CHARLES MALE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| T | ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A | ACETONE/ | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L | DMP | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 | Inflammation, Chronic | 2 | 1 2.0| __________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + A + + + + + + + A| 46 | Amyloid Deposition | | 2 1.5| Edema | 3 3 | 2 3.0| __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + M + + + + + + A + + + + + + + A| 45 | Edema | 3 3 | 2 3.0| __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + M + + A| 45 | __________________________________________________________________________|____________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Cortex, Amyloid Deposition | 4 | 1 4.0| __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Amyloid Deposition | 1 2 1 2 1 2 2 2 2| 17 1.5| __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Amyloid Deposition | 3 4 2 4 4 4 4 3 4 3 4 4 4 4 3 3| 28 3.6| Hemorrhage | 3 | 1 3.0| __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Amyloid Deposition | 2 3 2 2 2 2 2 4 2 2 2 2| 20 2.3| __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Amyloid Deposition | 2 2 2 2 2 2 2 2 2| 16 2.1| Basophilic Focus | X | 2 | Hematopoietic Cell Proliferation | 2 | 1 2.0| Hyperplasia | | 1 3.0| Inflammation, Chronic, Focal | 2 2 2 2 2 2 2 1 2 2 1 2 1 1 2 1 | 28 1.8| Karyomegaly | 3 | 1 3.0| Necrosis | 3 3 | 3 2.7| Vacuolization Cytoplasmic | | 1 2.0| Vacuolization Nuclear | 4 3 | 4 3.3| Hepatocyte, Hyperplasia | 2 | 2 2.0| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Edema | 3 3 2 | 7 2.3| Inflammation, Subacute | 3 | 1 3.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Amyloid Deposition | 2 2 2 2 3 4 2 3| 16 2.4| __________________________________________________________________________|____________| Stomach | + + + + + + + + + + + M + + + + + + + + + + + + +| 48 | Mucosa, Hyperplasia, Glandular | 3 | 1 3.0| Mucosa, Hyperplasia | 3 | 2 3.0| __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + M + + + + + + + + + + + + +| 48 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 69 NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97 Route: SKIN APPLICATION Time: 17:20:28 __________________________________________________________________________________________________________________________________ | 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | DAY ON TEST | 8| 8| 4| 8| 8| 8| 8| 8| 8| 1| 8| 8| 8| 8| 8| 9| 5| 9| 9| 9| 9| 9| 9| 9| 8| | | 7| 7| 1| 7| 0| 7| 7| 7| 7| 8| 7| 7| 7| 7| 7| 4| 4| 4| 0| 4| 4| 4| 4| 4| 9| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | CD-1 CRL MICE OUTBRED CHARLES MALE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| T | ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A | ACETONE/ | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L | DMP | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + M + + + + + + + + + + + + +| 48 | Amyloid Deposition | 2 3 2 2 2 2| 9 2.1| Inflammation, Chronic | | 1 2.0| Mucosa, Dilatation | | 1 2.0| Mucosa, Hyperplasia | 3 | 2 3.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Abscess | | 1 2.0| Amyloid Deposition | 1 2 2 2 2 1 1 2 3 2 3 3 2 3 2| 26 2.0| Inflammation, Chronic, Focal | 1 | 2 1.0| Atrium, Thrombosis | X X | 3 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + + + + + + + + M + + + + + + +| 48 | Adrenal Gland, Amyloid Deposition | | 1 4.0| Capsule, Hyperplasia | 1 2 2 2 2 1 2 2 2 1 2 1 1| 22 1.7| __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + M + + + + + + +| 48 | Amyloid Deposition | 3 4 2 3 2 2 2 4 3 3 2 3 3| 21 2.9| Hyperplasia, Focal | | 1 2.0| Hypertrophy, Focal | 2 | 1 2.0| Pigmentation | 2 2 3 2 2 3 2 2 3 3 1 2 | 26 2.2| __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + M + + + + + + +| 48 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Parathyroid Gland | + M + M + M M + + M + M + + + M + + + + + M + + M| 34 | Amyloid Deposition | 2 2 2 2 3 3 1 1 | 12 1.9| __________________________________________________________________________|____________| Pituitary Gland | + + + + M + + + + + + + + + + + + + + + + + + + +| 48 | Pars Distalis, Cyst | | 1 | Pars Distalis, Hyperplasia, Focal | 2| 1 2.0| Pars Distalis, Hyperplasia | | 1 1.0| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Amyloid Deposition | 1 3 2 1 1 3 2 2 3 2 2 2 2 3| 24 2.0| Follicle, Dilatation | | 1 2.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Tissue NOS | + | 3 | Abscess | | 2 4.0| _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 70 NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97 Route: SKIN APPLICATION Time: 17:20:28 __________________________________________________________________________________________________________________________________ | 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | DAY ON TEST | 8| 8| 4| 8| 8| 8| 8| 8| 8| 1| 8| 8| 8| 8| 8| 9| 5| 9| 9| 9| 9| 9| 9| 9| 8| | | 7| 7| 1| 7| 0| 7| 7| 7| 7| 8| 7| 7| 7| 7| 7| 4| 4| 4| 0| 4| 4| 4| 4| 4| 9| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | CD-1 CRL MICE OUTBRED CHARLES MALE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| T | ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A | ACETONE/ | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L | DMP | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Spermatocele | X | 1 | __________________________________________________________________________|____________| Penis | + + | 2 | Inflammation, Suppurative | 3 | 1 3.0| __________________________________________________________________________|____________| Preputial Gland | + | 2 | Abscess | | 1 4.0| __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + M + + + + + + + + +| 48 | Abscess | | 1 3.0| Inflammation, Chronic | 2 | 2 2.0| Inflammation | | 1 2.0| __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Dilatation | 3 3 | 6 2.5| Inflammation | 4 | 1 4.0| __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Amyloid Deposition | 2 3 4 1 4| 11 2.7| Fibrosis | 4 | 1 4.0| Inflammation, Chronic | 3 | 1 3.0| Interstitial Cell, Hyperplasia | 3 3| 5 2.6| Seminiferous Tubule, Degeneration | 3 3 1 2 4 3 2 2 2 2 4| 21 2.6| Seminiferous Tubule, Giant Cell | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + M + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hyperplasia | 3 | 2 3.0| Axillary, Hyperplasia | 3 | 1 3.0| __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Amyloid Deposition | 2 | 1 2.0| Cyst | X | 2 | Hematopoietic Cell Proliferation | 3 | 2 2.5| Hyperplasia | 3 3 4 | 6 3.3| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + M + + + + + + + +| 47 | Abscess | 3 | 1 3.0| Amyloid Deposition | 1 2 4 2 | 11 2.2| Hematopoietic Cell Proliferation | 2 | 1 2.0| Hyperplasia | 3 | 2 3.0| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Amyloid Deposition | 2 1 2 2 4 2 | 8 2.1| Hematopoietic Cell Proliferation | 2 3 1 1 4 2 3 2 2 2 2 2 1 1 2 2 2 1 2 2 2 4 2| 47 2.1| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 71 NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97 Route: SKIN APPLICATION Time: 17:20:28 __________________________________________________________________________________________________________________________________ | 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | DAY ON TEST | 8| 8| 4| 8| 8| 8| 8| 8| 8| 1| 8| 8| 8| 8| 8| 9| 5| 9| 9| 9| 9| 9| 9| 9| 8| | | 7| 7| 1| 7| 0| 7| 7| 7| 7| 8| 7| 7| 7| 7| 7| 4| 4| 4| 0| 4| 4| 4| 4| 4| 9| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | CD-1 CRL MICE OUTBRED CHARLES MALE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| T | ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A | ACETONE/ | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L | DMP | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Pigmentation, Hemosiderin | 1 2| 2 1.5| __________________________________________________________________________|____________| Thymus | M + + + + + + + + + + + + + + M + + M + M + M + +| 42 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M + M M M| 6 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Other, Abscess | | 2 4.0| Other, Acanthosis | 2 2 2 3 | 7 2.3| Other, Edema | 2 3 3| 3 2.7| Other, Exudate | X X | 5 | Other, Hyperkeratosis | 1 2 | 2 1.5| Other, Inflammation, Subacute | 4 3 4 4 | 8 3.6| Other, Ulcer | 4 3 4 4 | 8 3.5| Site of Application-Mass, Acanthosis,| | | Focal | | 1 4.0| __________________________________________________________________________|____________| Skin, Control | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Acanthosis | 1 | 1 1.0| Inflammation, Subacute | 1 | 1 1.0| __________________________________________________________________________|____________| Skin, Site of Application-No Mass | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Acanthosis | 2 2 1 1 | 11 1.6| Exudate | X X X | 7 | Hyperkeratosis | 1 | 4 1.8| Inflammation, Subacute | 3 | 7 2.0| Ulcer | 4 2 2 | 6 2.3| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + M + + + + + + + + + +| 47 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Thalamus, Mineralization, Focal | | 1 1.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Amyloid Deposition | 2 | 1 2.0| Congestion | 2 2 3 3 | 5 2.4| Alveolar Epithelium, Hyperplasia | 2 3 | 4 2.3| Alveolus, Infiltration Cellular, | | | Histiocyte | 1 | 4 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 72 NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97 Route: SKIN APPLICATION Time: 17:20:28 __________________________________________________________________________________________________________________________________ | 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | DAY ON TEST | 8| 8| 4| 8| 8| 8| 8| 8| 8| 1| 8| 8| 8| 8| 8| 9| 5| 9| 9| 9| 9| 9| 9| 9| 8| | | 7| 7| 1| 7| 0| 7| 7| 7| 7| 8| 7| 7| 7| 7| 7| 4| 4| 4| 0| 4| 4| 4| 4| 4| 9| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | CD-1 CRL MICE OUTBRED CHARLES MALE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| T | ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| A | ACETONE/ | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L | DMP | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | Interstitium, Inflammation, Chronic, | | | Focal | 2 4 3 3 | 9 2.4| Interstitium, Inflammation | 3 | 4 2.8| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Inflammation, Suppurative | | 1 2.0| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Ear | + | 1 | __________________________________________________________________________|____________| Eye | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Abscess | 4 | 1 4.0| Amyloid Deposition | 3 3 3 2 2 3 4 3 3 3 2 3 3| 23 2.9| Infarct | | 1 3.0| Nephropathy | 2 2 2 2 2 1 2 4 | 15 1.9| Cortex, Cyst | X X X X X X X | 9 | Pelvis, Dilatation | 2 2 3 2 2 2 3| 13 2.2| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + I + + + + + + + + + + + + + +| 46 | Calculus Micro Observation Only | X X X | 6 | Inflammation | 2 | 1 2.0| Mucosa, Hyperplasia | 2 | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 73 NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97 Route: SKIN APPLICATION Time: 17:20:28 _____________________________________________________________________________________________________________________ | 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| DAY ON TEST | 9| 9| 8| 8| 8| 8| 9| 9| 6| 9| 9| 9| 9| 9| 9| 9| 4| 9| 9| 7| 6| 9| 9| 9| 9| | 0| 0| 9| 9| 1| 6| 0| 0| 7| 0| 5| 5| 5| 5| 5| 5| 2| 5| 5| 5| 5| 0| 0| 0| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CD-1 CRL MICE OUTBRED CHARLES MALE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| ACETONE/ | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| ACETONE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + A + + A + + + + + + + + + + A A + + M +| Inflammation, Chronic | | __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| Mucosa, Necrosis | 4 | __________________________________________________________________________| Intestine Large, Cecum | + + + + + A + + + + + + + + + + + + + A A + + + +| Amyloid Deposition | | Edema | 4 | __________________________________________________________________________| Intestine Large, Colon | + + + + + A + + + + + + + + + + + + + + + + + + +| Edema | | __________________________________________________________________________| Intestine Large, Rectum | + + + + + A + + + + + + + + + + + + + A A + + + +| __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + A + + + + + + + + + + + + + + A + + + +| Amyloid Deposition | 1 2 1 1 1 2 3 2 1 1| __________________________________________________________________________| Intestine Small, Ileum | + + + + + A + + + + + + + + + + + + + A A + + + +| Amyloid Deposition | 3 4 3 3 3 3 3 3 3 4 4 4 3 3 4| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + A + + + + + + + + M + + + + A A + + + +| Amyloid Deposition | 2 2 1 2 2 2 2 1 2 3 2 1| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Abscess | | Amyloid Deposition | 2 2 2 2 2 2 2 2| Cyst Multilocular | | Eosinophilic Focus | | Hematopoietic Cell Proliferation | 3 4 | Inflammation, Chronic, Focal | 2 1 1 1 2 1 2 2 2 1 1 2 2 2 1 1| Karyomegaly | | Necrosis | 2 1 | Regeneration, Focal | | Vacuolization Cytoplasmic | | Centrilobular, Cytomegaly | 2 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Edema | 2 2 3 | Hypertrophy, Focal | 2 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Amyloid Deposition | 2 2 2 2 2 2 4 4 2 2 | __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Amyloid Deposition | 2 2 2 1 1| Dilatation | | Inflammation, Chronic | | Necrosis, Focal | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | _____________________________________________________________________________________________________________________| Page 74 NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97 Route: SKIN APPLICATION Time: 17:20:28 _____________________________________________________________________________________________________________________ | 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| DAY ON TEST | 9| 9| 8| 8| 8| 8| 9| 9| 6| 9| 9| 9| 9| 9| 9| 9| 4| 9| 9| 7| 6| 9| 9| 9| 9| | 0| 0| 9| 9| 1| 6| 0| 0| 7| 0| 5| 5| 5| 5| 5| 5| 2| 5| 5| 5| 5| 0| 0| 0| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CD-1 CRL MICE OUTBRED CHARLES MALE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| ACETONE/ | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| ACETONE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Abscess | | Amyloid Deposition | 2 2 2 1 2 2 2 1 1 2 2 2 3 2 2 2 2| Inflammation, Chronic, Focal | 2 2 | Atrium, Thrombosis | | Ventricle, Thrombosis | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pigmentation | 2 | Capsule, Hyperplasia | 2 1 3 2 3 2 2 2 2 2 2 3| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Amyloid Deposition | 3 3 2 2 2 2 4 2 3 3 3 3 2 3 3| Hyperplasia, Focal | | Hypertrophy, Focal | | Infiltration Cellular, Plasma Cell | | Infiltration Cellular, Plasma Cell, | | Lymphocyte | | Pigmentation | 2 2 2 1 1 1 2 2 2 1 | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | M M M M M M M M M M + M M M M M + M M M + + M M M| Amyloid Deposition | 1 | __________________________________________________________________________| Pituitary Gland | + + + + + M + + M + + + + + + + + + + + + + + + +| Pars Distalis, Hyperplasia, Focal | | Pars Intermedia, Cyst | X | __________________________________________________________________________| Thyroid Gland | + + + + + A + + + + + + + + + + + + I + + + + + +| Amyloid Deposition | 2 2 1 2 2 2 2 1 2 3 3 2 2 1| Follicle, Dilatation | 3 3 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Tissue NOS | | Abscess | | Granuloma | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Coagulating Gland | + | Abscess | 4 | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Subacute | | __________________________________________________________________________| Penis | + + + | __________________________________________________________________________| Preputial Gland | +| Inflammation | 3| _____________________________________________________________________________________________________________________| Page 75 NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97 Route: SKIN APPLICATION Time: 17:20:28 _____________________________________________________________________________________________________________________ | 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| DAY ON TEST | 9| 9| 8| 8| 8| 8| 9| 9| 6| 9| 9| 9| 9| 9| 9| 9| 4| 9| 9| 7| 6| 9| 9| 9| 9| | 0| 0| 9| 9| 1| 6| 0| 0| 7| 0| 5| 5| 5| 5| 5| 5| 2| 5| 5| 5| 5| 0| 0| 0| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CD-1 CRL MICE OUTBRED CHARLES MALE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| ACETONE/ | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| ACETONE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | __________________________________________________________________________| Prostate | + + + + M + + M + + + + + + + + + + + + + + + + +| Hyperplasia | | Inflammation | | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| Dilatation | 3 3 4 3| Fibrosis | | Inflammation | | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Amyloid Deposition | 3 1 2 3 3 | Interstitial Cell, Hyperplasia | 1 2 1 | Seminiferous Tubule, Degeneration | 3 2 1 1 2 3 1 3 2 1 3 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + M + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| Axillary, Hyperplasia | 3 | Mediastinal, Hyperplasia | | Pancreatic, Hyperplasia | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + M + + + + + + + + + + + + + + +| Abscess | 4 | Amyloid Deposition | 2 | Cyst | X | Hyperplasia | 3 3 3 4 4 3 4 3| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + M + + + + + + M M + + A A + + M +| Abscess | | Amyloid Deposition | 2 2 2 2 2 3 | Hematopoietic Cell Proliferation | | Hemorrhage | 3 | Hyperplasia | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Amyloid Deposition | 2 1 2 2 2 3| Hematopoietic Cell Proliferation | 2 4 2 2 3 2 3 4 2 2 1 2 1 2 1 3 3 1 3 3 2 2 3 | __________________________________________________________________________| Thymus | + + + + M + + + M + + + + + + + + + + + + + + + I| Cyst | | Hyperplasia | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M + M M M M + M M M + M M + M M + M + M M M M +| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Other, Abscess | | Other, Acanthosis | 3 2 3 3 2 2 2 2| Other, Edema | | Other, Exudate | X X X X X X X| Other, Hyperkeratosis | 2 2 2 2 | _____________________________________________________________________________________________________________________| Page 76 NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97 Route: SKIN APPLICATION Time: 17:20:28 _____________________________________________________________________________________________________________________ | 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| DAY ON TEST | 9| 9| 8| 8| 8| 8| 9| 9| 6| 9| 9| 9| 9| 9| 9| 9| 4| 9| 9| 7| 6| 9| 9| 9| 9| | 0| 0| 9| 9| 1| 6| 0| 0| 7| 0| 5| 5| 5| 5| 5| 5| 2| 5| 5| 5| 5| 0| 0| 0| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CD-1 CRL MICE OUTBRED CHARLES MALE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| ACETONE/ | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| ACETONE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | Other, Inflammation, Subacute | 4 2 4 3 4 4 4| Other, Ulcer | 4 4 3 4 4 4 4 4 4| Site of Application-Mass, Acanthosis,| | Focal | | __________________________________________________________________________| Skin, Control | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skin, Site of Application-No Mass | + + + + + + + + + + + + + + + + + + + + + + + + +| Acanthosis | 3 1 2 2 1 2 | Exudate | X X X | Hyperkeratosis | 2 | Inflammation, Subacute | 3 1 2 2 1 1 1 | Ulcer | 2 3 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + M + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + M + +| Thalamus, Mineralization, Focal | 1 1 1 1| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Abscess | | Amyloid Deposition | 2 | Atelectasis | | Congestion | 3 | Hemorrhage | | Leukocytosis | 4 3 2 | Alveolar Epithelium, Hyperplasia | | Alveolar Epithelium, Metaplasia, | | Focal, Squamous | 2 | Alveolus, Infiltration Cellular, | | Histiocyte | 1 | Bronchiole, Inflammation, | | Proliferative | 3 | Interstitium, Inflammation, Chronic, | | Focal | 4 | Interstitium, Inflammation | 2 3 3 | Pleura, Fibrosis, Focal | | Pleura, Inflammation, Suppurative | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + I + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | + | _____________________________________________________________________________________________________________________| Page 77 NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97 Route: SKIN APPLICATION Time: 17:20:28 _____________________________________________________________________________________________________________________ | 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| DAY ON TEST | 9| 9| 8| 8| 8| 8| 9| 9| 6| 9| 9| 9| 9| 9| 9| 9| 4| 9| 9| 7| 6| 9| 9| 9| 9| | 0| 0| 9| 9| 1| 6| 0| 0| 7| 0| 5| 5| 5| 5| 5| 5| 2| 5| 5| 5| 5| 0| 0| 0| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| CD-1 CRL MICE OUTBRED CHARLES MALE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| ACETONE/ | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| ACETONE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM - cont | | | | __________________________________________________________________________| Eye | | Cornea, Inflammation, Chronic | | __________________________________________________________________________| Harderian Gland | | Inflammation, Chronic | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Abscess | 4 3 | Amyloid Deposition | 3 3 2 3 2 2 2 4 2 2 3 2 4 4 2 3| Infiltration Cellular, Plasma Cell | 3 | Nephropathy | 2 2 2 2 3 | Cortex, Cyst | X X X | Pelvis, Dilatation | 2 3 2 2 2| __________________________________________________________________________| Urinary Bladder | + + + + + A + + + + + + + + + + + + + A A + + + +| _____________________________________________________________________________________________________________________| Page 78 NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97 Route: SKIN APPLICATION Time: 17:20:28 __________________________________________________________________________________________________________________________________ | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| | DAY ON TEST | 9| 9| 9| 9| 9| 7| 9| 9| 9| 1| 5| 9| 8| 9| 1| 9| 9| 7| 9| 6| 9| 9| 2| 9| 9| | | 0| 0| 0| 0| 0| 9| 5| 5| 5| 6| 3| 5| 9| 9| 2| 3| 3| 7| 3| 7| 3| 3| 8| 3| 3| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | CD-1 CRL MICE OUTBRED CHARLES MALE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| T | ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A | ACETONE/ | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L | ACETONE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + M + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Gallbladder | + + + + + + + + + + A + M + + + + + + A + + + + +| 42 | Inflammation, Chronic | 2 | 1 2.0| __________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mucosa, Necrosis | | 1 4.0| __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + M + + + + + +| 46 | Amyloid Deposition | 2 | 1 2.0| Edema | | 1 4.0| __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Edema | 3 | 1 3.0| __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + M| 46 | __________________________________________________________________________|____________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Amyloid Deposition | 1 2 1 2 3 3 | 16 1.7| __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | Amyloid Deposition | 3 2 3 3 3 4 3 2 3 4 4 4 3 2 | 29 3.2| __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + A + + M + +| 44 | Amyloid Deposition | 2 2 2 2 3 2 3 | 19 2.0| __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Abscess | 4 4 4 | 3 4.0| Amyloid Deposition | 2 4 2 2 3 | 13 2.2| Cyst Multilocular | X | 1 | Eosinophilic Focus | X | 1 | Hematopoietic Cell Proliferation | 3 3 4 2 2 2 2 | 9 2.8| Inflammation, Chronic, Focal | 2 2 2 2 2 2 2 2 2 2| 26 1.7| Karyomegaly | 3 | 1 3.0| Necrosis | 2 4 | 4 2.3| Regeneration, Focal | 2 | 1 2.0| Vacuolization Cytoplasmic | 3 | 1 3.0| Centrilobular, Cytomegaly | | 1 2.0| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Edema | 2 | 4 2.3| Hypertrophy, Focal | | 1 2.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Amyloid Deposition | 2 2 3 4 | 14 2.5| __________________________________________________________________________|____________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Amyloid Deposition | 2 2 | 7 1.7| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 79 NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97 Route: SKIN APPLICATION Time: 17:20:28 __________________________________________________________________________________________________________________________________ | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| | DAY ON TEST | 9| 9| 9| 9| 9| 7| 9| 9| 9| 1| 5| 9| 8| 9| 1| 9| 9| 7| 9| 6| 9| 9| 2| 9| 9| | | 0| 0| 0| 0| 0| 9| 5| 5| 5| 6| 3| 5| 9| 9| 2| 3| 3| 7| 3| 7| 3| 3| 8| 3| 3| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | CD-1 CRL MICE OUTBRED CHARLES MALE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| T | ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A | ACETONE/ | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L | ACETONE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | Dilatation | 2 | 1 2.0| Inflammation, Chronic | 2 | 1 2.0| Necrosis, Focal | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Abscess | 3 | 1 3.0| Amyloid Deposition | 2 1 2 1 3 2 1 3 1 | 26 1.8| Inflammation, Chronic, Focal | 3 | 3 2.3| Atrium, Thrombosis | X | 1 | Ventricle, Thrombosis | 4 | 1 4.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Pigmentation | | 1 2.0| Capsule, Hyperplasia | 2 3 1 2 2 1 2 2 2| 21 2.0| __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Amyloid Deposition | 2 2 3 4 3 3 3 1 | 23 2.7| Hyperplasia, Focal | 2 | 1 2.0| Hypertrophy, Focal | 2 | 1 2.0| Infiltration Cellular, Plasma Cell | 2 | 1 2.0| Infiltration Cellular, Plasma Cell, | | | Lymphocyte | 4 | 1 4.0| Pigmentation | 2 2 3 2 2 2 1 2 2 2 2| 21 1.8| __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hematopoietic Cell Proliferation | 2 | 1 2.0| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Parathyroid Gland | M M M M M M M M M + + M + M + + M M M M M M + M +| 11 | Amyloid Deposition | 2 | 2 1.5| __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Pars Distalis, Hyperplasia, Focal | 2| 1 2.0| Pars Intermedia, Cyst | | 1 | __________________________________________________________________________|____________| Thyroid Gland | + + + M + + + + + + + + + + + + + + + + M + + + +| 46 | Amyloid Deposition | 2 2 4 2 | 18 2.1| Follicle, Dilatation | | 2 3.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Tissue NOS | + + + | 3 | Abscess | 4 | 1 4.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 80 NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97 Route: SKIN APPLICATION Time: 17:20:28 __________________________________________________________________________________________________________________________________ | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| | DAY ON TEST | 9| 9| 9| 9| 9| 7| 9| 9| 9| 1| 5| 9| 8| 9| 1| 9| 9| 7| 9| 6| 9| 9| 2| 9| 9| | | 0| 0| 0| 0| 0| 9| 5| 5| 5| 6| 3| 5| 9| 9| 2| 3| 3| 7| 3| 7| 3| 3| 8| 3| 3| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | CD-1 CRL MICE OUTBRED CHARLES MALE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| T | ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A | ACETONE/ | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L | ACETONE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | __________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM - cont | | | | | | Granuloma | 4 | 1 4.0| _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Coagulating Gland | | 1 | Abscess | | 1 4.0| __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Subacute | 3 | 1 3.0| __________________________________________________________________________|____________| Penis | + + | 5 | __________________________________________________________________________|____________| Preputial Gland | | 1 | Inflammation | | 1 3.0| __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + M + + +| 47 | Hyperplasia | 2 | 1 2.0| Inflammation | 2 | 1 2.0| __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Dilatation | 2 3 3 3 | 8 3.0| Fibrosis | 2 | 1 2.0| Inflammation | 2 | 1 2.0| __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Amyloid Deposition | 2 2 1 3 | 9 2.2| Interstitial Cell, Hyperplasia | | 3 1.3| Seminiferous Tubule, Degeneration | 1 2 2 1 3 1 2 | 18 1.9| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + M + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Axillary, Hyperplasia | | 1 3.0| Mediastinal, Hyperplasia | 4 3 | 2 3.5| Pancreatic, Hyperplasia | 4 | 1 4.0| __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Abscess | 3 | 2 3.5| Amyloid Deposition | 2 | 2 2.0| Cyst | X | 2 | Hyperplasia | 3 3 3 4 3 3 3 4 | 16 3.3| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + M + + + + + + + + + + + + +| 43 | Abscess | 3 | 1 3.0| Amyloid Deposition | 2 2 2 2 2 2 2 1 | 14 2.0| Hematopoietic Cell Proliferation | 3 | 1 3.0| Hemorrhage | | 1 3.0| Hyperplasia | 3 | 1 3.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 81 NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97 Route: SKIN APPLICATION Time: 17:20:28 __________________________________________________________________________________________________________________________________ | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| | DAY ON TEST | 9| 9| 9| 9| 9| 7| 9| 9| 9| 1| 5| 9| 8| 9| 1| 9| 9| 7| 9| 6| 9| 9| 2| 9| 9| | | 0| 0| 0| 0| 0| 9| 5| 5| 5| 6| 3| 5| 9| 9| 2| 3| 3| 7| 3| 7| 3| 3| 8| 3| 3| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | CD-1 CRL MICE OUTBRED CHARLES MALE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| T | ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A | ACETONE/ | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L | ACETONE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Amyloid Deposition | 2 2 2 2 | 10 2.0| Hematopoietic Cell Proliferation | 2 2 1 2 3 4 2 1 2 4 4 2 3 4 3 2 2 1 3 3 2 2 4 2 2| 48 2.4| __________________________________________________________________________|____________| Thymus | + + + + + M + + + + + + + M + + + M + + + + + + M| 43 | Cyst | X | 1 | Hyperplasia | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M M + + M M M + + M + M M M M M M M M M + M + M M| 14 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Other, Abscess | 4 4 | 2 4.0| Other, Acanthosis | 2 3 3 2 3 3 2 | 15 2.5| Other, Edema | 3 | 1 3.0| Other, Exudate | X X X X X X X | 14 | Other, Hyperkeratosis | 2 2 2 | 7 2.0| Other, Inflammation, Subacute | 3 3 3 4 4 4 4 3 | 15 3.5| Other, Ulcer | 4 4 4 3 3 4 4 | 16 3.8| Site of Application-Mass, Acanthosis,| | | Focal | 4 | 1 4.0| __________________________________________________________________________|____________| Skin, Control | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Skin, Site of Application-No Mass | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Acanthosis | 1 2 | 8 1.8| Exudate | X | 4 | Hyperkeratosis | | 1 2.0| Inflammation, Subacute | 1 2 | 9 1.6| Ulcer | | 2 2.5| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Thalamus, Mineralization, Focal | 1 1 1 2 1 | 9 1.1| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Abscess | 4 4 | 2 4.0| Amyloid Deposition | | 1 2.0| Atelectasis | 3 | 1 3.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 82 NTP Experiment-Test: 05119-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: INIT/PROMOT DIETHYLPHTHALATE/DIMETHYLPHTHALATE Date: 04/24/97 Route: SKIN APPLICATION Time: 17:20:28 __________________________________________________________________________________________________________________________________ | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| | DAY ON TEST | 9| 9| 9| 9| 9| 7| 9| 9| 9| 1| 5| 9| 8| 9| 1| 9| 9| 7| 9| 6| 9| 9| 2| 9| 9| | | 0| 0| 0| 0| 0| 9| 5| 5| 5| 6| 3| 5| 9| 9| 2| 3| 3| 7| 3| 7| 3| 3| 8| 3| 3| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | CD-1 CRL MICE OUTBRED CHARLES MALE | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| T | ANIMAL ID | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| A | ACETONE/ | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| L | ACETONE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | Congestion | 2 2 | 3 2.3| Hemorrhage | 2 | 1 2.0| Leukocytosis | 4 3 3 | 6 3.2| Alveolar Epithelium, Hyperplasia | 2 3 | 2 2.5| Alveolar Epithelium, Metaplasia, | | | Focal, Squamous | | 1 2.0| Alveolus, Infiltration Cellular, | | | Histiocyte | 2 2 2 | 4 1.8| Bronchiole, Inflammation, | | | Proliferative | | 1 3.0| Interstitium, Inflammation, Chronic, | | | Focal | 1 2 2 1 3 | 6 2.2| Interstitium, Inflammation | 3 2 3 2 3 2 | 9 2.6| Pleura, Fibrosis, Focal | 2 | 1 2.0| Pleura, Inflammation, Suppurative | 4 | 1 4.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Ear | + | 2 | __________________________________________________________________________|____________| Eye | + + | 2 | Cornea, Inflammation, Chronic | 2 2 | 2 2.0| __________________________________________________________________________|____________| Harderian Gland | + | 1 | Inflammation, Chronic | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Abscess | 3 | 3 3.3| Amyloid Deposition | 2 2 2 3 3 1 2 2 2 3 2 | 27 2.5| Infiltration Cellular, Plasma Cell | 3 3 | 3 3.0| Nephropathy | 2 2 2 2 3 1 1 1 1| 14 1.9| Cortex, Cyst | X X| 5 | Pelvis, Dilatation | 2 3 2 2 2 2 | 11 2.2| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 83 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------
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The National Institute of Environmental Health Sciences is one of the National Institutes of Health within the U.S. Department of Health and Human Services. The National Toxicology Program is headquartered on the NIEHS campus in Research Triangle Park, NC.