HEALTH CONSULTATION
Evaluation of Health Impacts from Potential Past Exposure to
Tetrachloroethylene in the Natick Public Water Supply
Prepared in relation to the
NATICK LABORATORY ARMY RESEARCH
(a/k/a U.S. ARMY SOLDIER SYSTEM COMMAND (SSCOM) - NATICK)
NATICK, MIDDLESEX COUNTY, MASSACHUSETTS
CERCLIS NO. MA1210020631
March 10, 1998
Prepared by:
Federal Facilities Assessment Branch
Division of Health Assessment and Consultation
TABLE OF CONTENTS
LIST OF ACRONYMS AND ABBREVIATIONS
BACKGROUND AND STATEMENT OF ISSUES
CONCLUSIONS AND RECOMMENDATIONS
PREPARERS AND REVIEWERS OF REPORT
APPENDIX C - Glossary of Terms
APPENDIX D - Response to Public Comments
LIST OF TABLES
(in Appendix A)
Table A-1: Estimation of Daily Human Exposure Dose for Ingestion of PCE in Water
Table A-2: Estimation of Daily Human Exposure Dose for Inhalation of Contaminants in Air
Table A-3: Summary of Animal Studies -- Oral Exposure
Table A-4: Summary of Animal Studies -- Inhalation Exposure
Table A-5: Summary of Human Health Studies -- Oral and Inhalation Exposure
LIST OF FIGURES
(in Appendix B)
Figure 1: Location of Census Tracts in Natick, Massachusetts (source: MDPH, 1997b)
| ATSDR | Agency for Toxic Substances and Disease Registry |
| ACGIH | American Conference of Governmental Industrial Hygienists |
| CNS | Central Nervous System |
| Conc (or conc) | concentration |
| dL | deciliter |
| dy | day |
| EPA | Environmental Protection Agency |
| Gd | Gestational day |
| hr | hour |
| kg | kilogram |
| LBW | Low birthweight |
| LOAEL | Lowest-Observed-Adverse-Effect-Level |
| MBW | Mean birth weight |
| MCL | Maximum Contaminant Level |
| mg/kg | milligram per kilogram |
| mg/kg/day | milligrams per kilogram per day (equivalent to mg/kg/d) |
| µg/L or µg/kg | microgram per liter or microgram per kilogram |
| mg/m3 | milligrams per meter cubed |
| MRL | Minimal Risk Level |
| NCI | National Cancer Institute |
| ND | Non-detect |
| NOAEL | No-Observed-Adverse-Effect-Level |
| NPL | National Priorities List |
| NTD | Neural tube defect |
| OR | Odds ratio |
| PB/PK | Physiologically-Based/Pharmacokinetic (model) |
| PCE | Perchloroethylene or tetrachloroethylene |
| PHA | Public Health Assessment |
| ppb | parts per billion (equivalent to µg/L or µg/kg) |
| ppm | parts per million (equivalent to mg/kg or µg/ml) |
| RAB | Restoration Advisory Board |
| SEER | Surveillance Epidemiology End Result |
| SGA | Small for gestational age |
| SIR | Standardized incidence rate |
| SCE | Sister chromatid exchange |
| SMR | Standardized mortality ratio |
| TCE | Trichloroethylene |
| TCA | Trichloroacetic acid |
| TLV | Threshold Limit Value |
| VLBW | Very low birthweight |
| VOCs | Volatile organic compounds |
| wk | week |