Publications
Alon, S., Eisenberg, E., Jacob-Hirsch, J., Rechavi, G., Vatine, G., Toyama, R., Coon, S.L., Klein, D.C., and Gothilf, Y (2009) A new cis-acting regulatory element driving gene expression in the zebrafish pineal gland Bioinformatics, 25: 559 - 562. PDF
Bailey, M.J., Coon, S.L., Carter, D.A., Humphries, A. Kim, J.-S., Shi, Q. Gaildrat, p., Morin, f., Ganguly, S., Hogenesch, J. B., Weller, J. L., Rath, M. F., Møller, M., Baler, R., Sugden, D., Rangel, Z.G., Munson, P.J. and Klein, D.C. Night/day changes in pineal expression of >600 genes: Central role of adrenergic/cAMP signaling. J. Biol. Chem., Dec 2008; doi:10.1074/jbc.M808394200.
Rath, M.F., Bailey, M.J., Kim, J.S., Coon, S.L., Klein, D.C. and Møller, M.(2009) Developmental and daily expression of the Pax4 and Pax6 homeobox genes in the rat retina: Localization of Pax4 in photoreceptor cells. J Neurochem. 108: 285-294 PDF
Rath, M.F., Bailey, M.J., Kim, J.S., Ho, A.K., Gaildrat, P., Coon, S.L., Møller, M. and Klein DC. (2008) Developmental and diurnal dynamics of Pax4 expression in the mammalian pineal gland: Nocturnal down-regulation is mediated by adrenergic-cyclic AMP signaling. Endocrinology. [Epub ahead of print].PDF
Klitten, L.L., Rath, M.F., Coon, S.L., Kim, J.S., Klein, D.C. and Møller, M.(2008) Localization and regulation of dopamine receptor D4 expression in the adult and developing rat retina. Exp Eye Res. 2008 Nov;87(5):471-7.PDF
Pavlicek, J., Coon, S.L., Ganguly, S., Weller, J.L., Hassan, S.A., Sackett, D.L. and Klein, D.C.(2008) Evidence that proline focuses movement of the floppy loop of arylalkylamine N-acetyltransferase (EC 2.3.1.87). J Biol Chem. 28314552-8. Epub 2008 Mar 24. PDF
Ganguly S, Grodzki C, Sugden D, Møller M, Odom S, Gaildrat P, Gery I, Siraganian RP, Rivera J, Klein DC.(2007) Neural adrenergic/cyclic AMP regulation of the immunoglobulin E receptor alpha-subunit expression in the mammalian pinealocyte: a neuroendocrine/immune response link? J Biol Chem. 2007 Nov 9;282(45):32758-64. Epub 2007 Aug 29. PMID: 17728245. PDF
Humphries, A., Wells, T., Baler, R., Klein, D.C., Carter, D.A. (2007) Rodent Aanat: Intronic E-box sequences control tissue specificity but not rhythmic expression in the pineal gland. Mol Cell Endocrinol 270:43-49 PDF
Hwang, Y., Ganguly, S., Ho, A.K., Klein, D.C., and Cole, P.A. (2007) Enzymatic and cellular study of a serotonin N-acetyltransferase phosphopantetheine-based prodrug. Bioorg Med Chem. 15:2147-2155. PDF
Klein, D.C. (2007) Arylalkylamine N-Acetyltransferase: “the Timezyme”. J Biol Chem. 282:4233-4237. PDF
Klein, D.C. (2007) The Pineal Gene Expression Party: Who’s the Surprise Guest? Endocrinol 148:1463-1464. PDF
Kim, J.S., Bailey, M.J., Ho, A.K., Møller, M., Gaildrat, P., and Klein, D.C. (2007) Daily Rhythm in Pineal Phosphodiesterase Activity Reflects Adrenergic/cAMP Induction of the PDE4B2 Variant. Endocrinology. PDF
Estela M. Muñoz, Michael J. Bailey, Martin F. Rath, Qiong Shi, Fabrice Morin, Steven L. Coon, Morten Møller, David C. Klein
(2007) NeuroD1: developmental expression and regulated genes in the rodent pineal gland
Journal of Neurochemistry (OnlineEarly Articles). doi:10.1111/j.1471-4159.2007.04605.x PDF
Zilberman-Peled, B., Appelbaum, L., Vallone, D., Foulkes, N.S., Anava, S., Anzulovich, A., Coon, S.L., Klein, D.C., Falcon, J., Ron, B., Gothilf, Y. (2007) Transcriptional regulation of arylalkylamine-N-acetyltransferase-2 gene in the pineal gland of the gilthead seabream. J Neuroendocrinol. 19:46-53. PDF
Besseau, L., Benyassi, A., Moller, M., Coon, S.L., Weller, J.L., Boeuf, G., Klein, D.C., and Falcon, J. (2006) Melatonin pathway: breaking the ‘high-at-night’ rule in trout retina. Experimental Eye Research. 82:620-627. PDF
Coon, S.L. and Klein, D.C. (2006) Evolution of arylalkylamine N-acetyltransferase: Emergence and divergence. Mol Cell Endocrinol. pp 1-9. PDF
Klein, D.C. (2006) Evolution of the vertebrate pineal gland: the AANAT hypothesis. Chronobiology International. 23:5-20. PDF
Moller, M., Rath, M.F., and Klein, D.C. (2006) The perivascular phagocyte of the mouse pineal gland: an antigen-presenting cell. Chronobiology International. 23:393-401. PDF
Pozdeyev, N., Taylor, C., Haque, R., Chaurasia, S.S., Visser, A., Thazyeen, A., Du, Y., Fu, H., Weller, J., Klein, D.C., and P. Iuvone, M. (2006) Photic regulation of arylalkylamine N-acetyltranferase binding to 14-3-3 proteins in retinal photoreceptor cells. J Neuroscience 26:9153-9161. PDF
Rath, M.F., Muñoz, E., Ganguly, S., Morin, F., Shi, Q., Klein, D.C., and Moller, M. (2006) Expression of the Otx2 homeobox gene in the developing mammalian brain: embryonic and adult expression in the pineal gland. J. Neurochem. 97:556-566. PDF
Vuilleumier, R., Besseau, L., Boeuf, G., Piparelli, A., Gothilf, Y., Gehring, W.G., Klein, D.C., and Falcón, J. (2006) Starting the zebrafish pineal circadian clock with a single photic transition. Endocrinology. 147:2273-2279. PDF
Gaildrat, P., Moller, M., Mukda, S., Humphries, A., Carter, D.A., Ganapathy, V., Klein, D.C. (2005) A novel pineal-specific product of the oligopeptide transporter pept1 gene: Circadian expression mediated by cAMP activation of an intronic promoter. J Biol Chem. 280:16851-16860. PDF
Ganguly, S., Weller, J.L., Ho, A., Chemineau, P., Malpaux, B., and Klein, D.C. (2005) Melatonin synthesis: 14-3-3-dependent activation and inhibition of arylalkylamine N-acetyltransferase mediated by phosphoserine-205. Proc Natl Acad Sci USA. 102:1222-1227. PDF
Iuvone, P.M., Tosini, G., Pozdeyev, N., Haque, R., Klein, D.C., and Chaurasia, S.S. (2005) Circadian clocks, clock networks, arylalkylamine N-acetyltransferase, and melatonin in the retina. Progress in Retinal and Eye Research. 24:433-456. PDF
Kim, J.S., Coon, S.L., Blackshaw, S., Cepko, C.L., Moller, M., Mukda, S., Zhao, W.Q., Charlton, C.G., and Klein, D.C. (2005) Methionine adenosyltransferase (MAT): Adrenergic-cyclic AMP mechanism regulates a daily rhythm in pineal expression. J Biol Chem. 280:677-684. PDF
Zheng, W., Schwarzer, D., LeBeau, A., Weller, J.L., Klein, D.C. and Cole, P.A .(2005) Cellular Stability of Serotonin N-acetyltransferase Conferred by Ser205 Phosphono-difluoromethylene Alanine (Pfa) Substitution. J. Biol. Chem. 280:10462-10467. PDF
Appelbaum, L., Toyama, R., Dawid, I.B., Klein, D.C., Baler, R., Gothilf, Y. (2004) Zebrafish serotonin-N-acetyltransferase-2 gene regulation: Pineal-restrictive downstream module (PRDM) contains a functional E-box and three photoreceptor conserved elements. Mol Endocrinol 18:1210-1221. PDF
Humphries, A., Weller, J., Klein, D.C., Baler, R. and Carter, D.A. (2004) NGFI-B (Nurr77/Nr4a1) orphan nuclear receptor in rat pinealocytes: Circadian expression involves an adrenergic-cyclic AMP mechanism. J. Neurochem 91:946-955. PDF
Iyer, L.M., Aravind, L., Coon, S.L. Klein, D.C. and Koonin, E.V. (2004) Evolution of cell–cell signaling in animals: did late horizontal gene transfer from bacteria have a role? Trends in Genetics (In press, Available online 28 May 2004) 20:292-299. PDF
Klein, D.C. (2004) The 2004 Aschoff/Pittendrigh Lecture: Theory of the Origin of the Pineal Gland - A Tale of Conflict and Resolution. Journal of Biological Rhythms (In press) 19:264-279. PDF
Price DM, Chik CL, Terriff D, Weller J, Humphries A, Carter DA, Klein DC, Ho AK. (2004) Mitogen-activated protein kinase phosphatase-1 (MKP-1): >100-fold nocturnal and norepinephrine-induced changes in the rat pineal gland. FEBS Lett. 577(1-2):220-6. PDF
Chong, N.W., Chaurasia, S.S., Haque, R., Klein, D.C., Iuvone, P.M. (2003) Temporal-spatial characterization of chicken clock genes: circadian expression in retina, pineal gland, and peripheral tissues. J Neurochem 85:851-860. PDF
Falcon, J., Gothilf, Y., Coon, S.L., Boeuf, G., and Klein, D.C. (2003) Genetic, Temporal and Developmental Differences Between Melatonin Rhythm Generating Systems in the Teleost Fish Pineal Organ and Retina. J Neuroendocrinology 15:378-382. PDF
Klein, D.C., Ganguly, S., Coon, S.L., Shi, Q., Gaildrat, P., Morin, F., Weller, J.L., Obsil, T., Hickman, A., and Dyda, F. (2003) 14-3-3 proteins in pineal photoneuroendocrine transduction: How many roles? J Neuroendocrinology 15:370-377. PDF
Zheng, W., Zhang, Z., Ganguly, S., Weller, J.L., Klein, D.C., Cole, P.A. (2003) Cellular stabilization of the melatonin rhythm enzyme induced by nonhydrolyzable phosphonate incorporation. Nat Struct Biol. 10(12):1054-7. PDF
Coon, S.L., del Olmo, E., Young, III. W. S., and Klein, D.C. (2002) Melatonin synthesis enzymes in Macaca mulatta: Focus on arylalkylamine N-acetyltransferase (EC 2.3.1.87). J Clin Endocrinol Metab 87:4699-4706. PDF
Gothilf, Y., Toyama, R., Coon, S.L., Du, S-J., Dawid, I.B., and Klein, D.C. (2002) Pineal-specific expression of green fluorescent protein under the control of the serotonin-N-acetyltransferase gene regulatory regions in transgenic zebrafish. Dev Dyn 225(3):241-249. PDF
Ganguly, S., Coon, S.L., and Klein, D.C. (2002) Control of melatonin synthesis in the mammalian pineal gland. Cell and Tissue Res 309:127-137. PDF
Humphries, A., Klein, D.C., Baler, R., and Carter, D.A. (2002) cDNA array analysis of pineal gene expression reveals circadian rhythmicity of the dominant negative helix-loop-helix protein-encoding gene, Id-1. J Neuroendocrinology 14:101-108. PDF
Iuvone, P.M., Brown, A.D., Haque, R., Weller, J.L., Zawilska, J.B., Chaurasia, S.S., Ma, M.H., and Klein, D.C. (2002) Retinal melatonin production: Role of proteasomal proteolysis in circadian and photic control of arylalkylamine N-acetyltransferase. Invest Opthalmol and Visual Science 43:564-572. PDF
Klein, D.C., Ganguly, S., Coon, S., Weller, J.L., Obsil, T., Hickman. A., and Dyda, F. (2002) 14-3-3 Proteins and photoneuroendocrine transduction: role in controlling the daily rhythm in melatonin. Biochem Soc Trans 30: 365-373. PDF
Schomerus, C., Laedtke, E., Olcese, J., Weller, J.L., Klein, D.C., and Korf, H-W. (2002) Signal transduction and regulation of melatonin synthesis in bovine pinealocytes: impact of adrenergic, peptidergic and cholinergic stimuli. Cell Tissue Res 309:417-428. PDF
Coon, S.L. , Weller, J.L., Korf, H.-W., Namboodiri, M.A.A., Rollag, M. and Klein, D.C. (2001) cAMP regulation of arylalkylamine N-acetyltransferase (AANAT, EC 2.3.1.87): A new cell line (1E7) provides evidence of intracellular AANAT activation J. Biol.Chem 276:24097-24107. PDF
Falcón, J., Gallarneau, K., Coon, S.L., Weller, J.L., Ron, B., Chen, G., and Klein, D.C. (2001) Regulation of arylalkylamine N-aceytltransferase-2 (AANAT2, 2.3.1.87) in the fish pineal organ: Evidence for a role of proteasomal proteolysis. Endocrinology 142:1804-1813. PDF
Ganguly, S., Gastel, J., Weller, J.L., Schwartz, C., Jaffe, H., Namboodiri, M.A., Coon, S.L., Hickman, A.B., Rollag, M., Obsi, T., Beauverger, P., Ferry, G., Boutin, J.A., Klein, D.C. (2001) Role of a pineal cAMP-operated arylalkylamine N-acetyltransferase/14-3-3-binding switch in melatonin synthesis. Proc.Natl. Acad. Sci, U.S.A. 98:8083-8088. PDF
Ganguly, S., Mummaneni, P., Steinbach, P.J., Klein, D.C., and Coon, S.L. (2001) Characterization of the saccharomyces cerevisiae homolog of the melatonin rhythm enzyme arylalkylamine N-acetyltransferase (EC 2.3.1.87). J Biol Chem 276:47239-47247. PDF
Obsil, T., Ghirlando, R., Klein, D.C., Ganguly, S., and Dyda, F. (2001) Crystal Structure of the 14-3-3: Serotonin N-Acetyltransferase Complex: A Role for Scaffolding in Enzyme Regulation. Cell 105:257-267. PDF
Smith, M., Burke, Z., Humphries, A., Wells, T., Klein, D.C., Carter, D., and Baler, R. (2001) Tissue specific transgenic knock-down of Fos related antigen-2 (Fra-2) expression through use of dominent negative Fra-2. Molecular and Cell Biology 21: 3704-3713. PDF
Benyassi, A., Schwartz, C., Coon, S.L., Klein, D.C., Falcon, J. (2000) Melatonin synthesis: arylalkylamine N-acetyltransferases in trout retina and pineal organ are different. Neuroreport 11:255-258. PDF
Chong, N.W., Bernard, M., Klein, D.C. (2000) Characterization of the chicken serotonin N-acetyltransferase gene: Activation via clock gene heterodimer/E-box interaction. J Biol Chem 275:32991-32998. PDF
Dyda, F., Klein, D.C., and Hickman, A. (2000) GCN5-related N-acetyltransferases: A structural overview. Annu Rev Biophys Biomol Struct 29:81-103. PDF
Iuvone, P.M., Chong, N.W., Bernard, M., Brown, A.D., Thomas, K.B., and Klein, D.C. (2000) Melatonin biosynthesis in chicken retina: regulation of tryptophan hydroxylase and arylalkylamine N-acetyltransferase. In: Melatonin after Four Decades. (J. Olcese, Eds) Plenum Publishing Corp, New York, pp 31-41. PDF
Schomerus, C., Korf, H-W, Laedtke, E., Weller, J.L., Klein, D.C. (1999) Selective adrenergic/cyclic AMP-dependent switch-off of proteasomal proteolysis alone switches on neural signal transduction: An example from the bovine pineal gland. J Neurochem 2000 75: 2123-2132. PDF
Schwartz, W.J., Carpino, A., de la Iglesia, H.O., Baler, R., Klein, D.C., Nakabeppu, Y., Aronin, N. (2000) Differential regulation of fos family genes in the ventrolateral and dorsomedial subdivisions of the rat suprachiasmatic nucleus. Neuroscience. 2000 98(3):535-547. PDF
Zatz, M., Gastel, J.A., Heath III J.R., Klein D.C. (2000) Chick pineal melatonin synthesis: Light and cyclic AMP control abundance of serotonin N-acetyltransferase (AANAT, EC 2.3.1.87) protein. J Neurochem 74:2315-2321. PDF
Baler, R., Covington, S., and Klein, D.C. (1999) Rat arylalkylamine N-acetyltransferase gene: Upstream and intronic components of a bipartite promoter. Biology of the Cell 91: 699-705.
Bernard, M., Guerlotté, J., Grève, P., Gréchez-Cassiau, A., Iuvone, M.P., Zatz, M., Chong, N.W., Klein, D.C., and Voisin, P. (1999) Melatonin synthesis pathway: circadian regulation of the genes encoding the key enzymes in the chicken pineal gland and retina. Reproduction, Nutrition and Development 39:325-334.
Burke, Z., Wells, T., Carter, D., Klein, D.C. and Baler, R. (1999) Genetic Targeting: The serotonin N-acetyltransferase promoter imparts circadian expression selectively in the pineal gland of retina of transgenic rats. J Neurochemistry 73:1343-1349. PDF
Coon, S.L., Begay, V., Deurloo, D., Falcon, J. and Klein, D.C. (1999) Two arylalkylamine N-acetyltransferase genes mediate melatonin synthesis in fish. J. Biol. Chem 274:9076-9082.
Coon, S.L., Zarazaga, L.A., Malpaux, B., Ravault, J-P., Bodin, L., Voisin, P., Weller, J.L., Klein, D.C., and Chemineau, P. (1999) Genetic variability in plasma melatonin in sheep is due to pineal weight, not to variations in enzyme activities. American Journal of Physiology 277:792-797.
Fleming, J.V., Barrett, P., Coon, S.L., Klein, D.C. and Morgan, P. J. (1999) Ovine arylalkylamine N-acetyltransferase (AANAT) in the pineal and pituitary glands: Differences in function and regulation. Endocrinology 140:972-978.
Gothilf, Y., Coon, S.L., Toyama, R., Chitnis, A., Verghese, G., Klein, D.C. (1999) Zebrafish serotonin N-acetlytransferase-2: Marker for development of pineal photoreceptors and circadian clock function. Endocrinology 140:4895-4903.
Gréve, P., Gómez-Alonso, A., Bernard, M., Ma, M., Haque, R., Klein, D.C. and Iuvone, P.M. (1999) Serotonin N-acetyltransferase mRNA levels in photoreceptor-enriched chicken retinal cell cultures. Journal of Neurochemistry 73:1894-1900.
Hickman, A.B., Klein, D.C. and Dyda, F. (1999) Melatonin biosynthesis: The structure of serotonin N-acetyltransferase at 2.5 A resolution suggests a catalytic mechanism. Molecular Cell 3:23-32.
Hickman, A.B., Namboodiri, M.A.A., Klein, D.C. and Dyda, F. (1999) The structural basis of ordered substrate binding by serotonin N-acetyltransferase: Complex at 1.8Å resolution with a bisubstrate inhibitor. Cell 97:361-369.
Klein, D.C. (1999) Serotonin N-acetyltransferase. A personal historical perspective. Adv Exp Med Biol. 460:5-16. PDF
Zatz, M., Gastel, J.A., Heath III J.R., Klein D.C. (1999) Chick Pineal Melatonin Synthesis: Light and cAMP control abundance of serotonin N-acetyltransferase (AANAT, EC 2.3.1.87) protein. J Neurochem 74:2315-2321.
Begay, V., Falcon, J., Cahill, G., Klein, D.C. and Coon, S. (1998) Transcripts encoding two melatonin synthesis enzymes in the teleost pineal organ: Circadian regulation in pike and zebrafish, but not in trout. Endocrinology 139:905-912.
Chong, N.W., Iuvone, P.M., Bernard, M., Cassone, Vincent M. and Klein, D.C. (1998) Circadian expression of tryptophan hydroxylase mRNA in the chicken retina. Mol Brain Res 61:243-250.
Coon, S.L., Begay, V., Falcon, J., and Klein, D.C. (1998) Expression of melatonin synthesis genes is controlled by a circadian clock in the pike pineal organ but not in the trout. Biology of the Cell 90:399-405.
DeAngelis, J., Gastel, J.A., Klein, D.C. and Cole, P.A. (1998) Kinetic mechanism of serotonin N-acetyltransferase (EC 2.3.1.87). J Biol Chem 273:3045-3050.
Gastel, J.A., Roseboom, P.H., Rinaldi, P.A., Weller, J.L. and Klein, D.C. (1998) Melatonin production: Proteaosomal proteolysis in serotonin N-acetyltransferase regulation. Science 279:1358-1360.
Klein, D.C., Coon, S.L., Krzysztof, M., Bernard M., Roseboom, P.H., and Rodriguez, I.R. (1998) Biological rhythms and psychiatric disease: Focus on melatonin-related genes. In Genetics and Psychiatric Disorders J. Wahlstrom (ed) Pergamon 289-300.
Klein, D.C., Baler, R., Roseboom, P.H., Weller, J.L., Bernard, M., Gastel, J.A., Zatz, M., Iuvone, P.M., Begáy, V., Falcón, J., Cahill, G., Cassone, V.M. and Coon, S.L. (1998) The molecular basis of the pineal melatonin rhythm: Regulation of serotonin N-acetylation. Handbook of Behavioral State Control: Cellular and Molecular Mechanisms. R. Lydic and H. Baghdoyan, eds. CRC Press, Boca Raton 4:45-59. PDF
Roseboom,
P.H., Namboodiri, M.A.A., Zimonjic, D.B., Popescu, N.C., Rodriguez,
I.R. and Klein, D.C. (1998) Natural melatonin knockdown in C57BL/6J
MICE: Rare mechanism truncates serotonin N-acetyltransferase. Mol Brain
Res 63:189-197. PDF
Baler, R. and Klein, D.C. (1997) Circadian regulation of transcription factor FRA-2 in the rat pineal gland. Advances in Pineal Res., In: Pineal update: From Molecular Mechanisms to Clinical Implications (eds S.M. Webb, m. Puig-Domingo, M. Møller and P. Pevet), P.J.D. Publications Ltd, Westbury, Vol 9 37-47.
Baler, R., Covington, S., and Klein, D.C. (1997) The rat arylalkylanine N-acetyltransferase gene promoter: cAMP activation via a CRE/CCAAT complex. Journal of Biological Chemistry 272:6979-6985. PDF
Bernard, M., Klein, D.C. and Zatz, M. (1997) Chick pineal clock regulates serotonin N-acetyltransferase mRNA rhythm in culture. Proc. Natl. Acad. Sci. U.S.A. 94:304-309.
Bernard, M., Iuvone, P.M., Cassone, V.M., Roseboom, P.H., Coon, S. L. and Klein, D.C. (1997) Melatonin synthesis: Photic and circadian regulation of serotonin N-acetyltransferase mRNA in the chicken pineal gland and retina. J Neurochem 68:213-224.
Bernard, M., Iuvone, P.M., Cassone, V.M., Roseboom, P.H., Coon, S.L. and Klein, D.C. (1997) Chicken arylalkylamine-N-acetyltransferase: Cloning and circadian regulation in the pineal gland. Advances in Pineal Research, In: Pineal Update: From Molecular Mechanisms to Clinical Implications (eds S.M. Webb, M. Puig-Domingo, M. Møller and P. Pevet), P.J.D. Publications Ltd, Westbury, Vol 9, 29-36.
Coon, S.L., McCune, S.K., Sugden, D. and Klein, D.C. (1997) Regulation of a-1B-adrenergic receptor mRNA in the pineal gland: Day/night rhythm and beta-adrenergic [] cyclic AMP control. Mol. Pharmacology, 51:551-557
Iuvone, P.M., Bernard, M., Alonso-Gomez, A., Greve, P., Cassone, V.M. and Klein, D.C. (1997) Cellular and molecular regulation of serotonin N-acetyltransferase activity in chicken retinal photoreceptors. Biol Signals; 6:217-224.
Klein, D.C., Coon, S.L., Roseboom, P.H., Weller, J.L., Bernard, M., Gastel, J.A., Zatz, M., Iubone, M., Rodriquez, I.R., Begay, V., Falcόn, J., Cahill, G., Cassone, V.M. and Baler, R. (1997) The melatonin rhythm generating enzyme: Molecular regulation of serotonin N-acetyltransferase in the pineal gland. Recent Progress in Hormone Research 52: 307-357. PDF
Baler, R., Coon, S.L. and Klein, D.C. (1996) Orphan nuclear receptor RZRb: Cyclic AMP regulates expression in the pineal gland. Biochem Biophys Res Commun 220:975-978.
Bernard, M., Donohue, S.J., and Klein, D.C. (1996) Human hydroxyindole-O-methyltransferase in pineal gland, retina and Y-79 retinoblastoma cells. Brain Res. 696:37-48.
Bernard, M. and Klein, D.C. (1996) Retinoic acid increases hydroxyindole-O-methyltransferase activity and mRNA in human Y-79 retinoblastoma cells. J Neurochem 67:1032-1038. PDF
Bernard, M., Voisin, P., and Klein, D.C. (1996) Hydroxyindole-O-methyltransferase in Y-79 cells: Regulation by serum. Brain Res 727:118-124.
Coon, S.L., Mazuruk, K., Bernard, B., Roseboom, P.H., Klein, D.C. and Rodriguez, I.R. (1996) The human serotonin N-acetyltransferase (EC 2.3.1.87) Gene: Structure, chromosomal localization and tissue expression. Genomics 34:76-84.
Klein, D.C., Roseboom, P.H., and Coon, S.L. (1996) New light is shining on the melatonin rhythm enzyme: The first post cloning view. Trends in Endocrinology and Metabolism 7:106-112.
Roseboom, P.H., Coon, S.L., Baler, R., McCune, S.K., Weller, J.L., and Klein, D.C. (1996) Melatonin synthesis: Regulation of the more than 150-fold nocturnal increase in serotonin N-acetyltransferase messenger RNA in the rat pineal gland. Endocrinology 137:3033-3044.
Weller, J.L., Jaffee, H., Roseboom, P.H., Zylka, M. and Klein, D.C. (1996) 2D-PAGE analysis: Adrenergically regulated pineal protein AIP 37/6 is a phosphorylated isoform of cytosolic malate dehydrogenase. Brain Research 713:8-16. PDF
Sugden, D., Anwar, N., and Klein, D.C. (1996) Rat pineal alpha-1-adrenoceptor subtypes: Studies using radioligand binding and reverse transcription-polymerase chain reacation analysis. British Journal of Pharmacology 118:1246-1252.
Baler, R. and Klein, D.C. (1995) Circadian expression of transcription factor Fra 2 in the rat pineal gland. J Biol Chem 270:27319-27325. PDF
Bernard, M., Donohue, S.J., and Klein, D.C. (1995) Human hydroxyindole-O-methyltransferase in pineal gland, retina and Y79 retinoblastoma cells. Brain Research. 696:37-48. PDF
Coon, S.L., Roseboom, P.H., Baler, R., Weller, J.L., Namboodiri, M.A.A., Koonin, E.V. and Klein, D.C. (1995) Pineal Serotonin N-acetyltransferase (EC 2.3.1.87): Expression cloning and molecular analysis. Science 270:1681-1683. PDF
Roseboom, P.H. and Klein, D.C. (1995) Norepinephrine stimulation of pineal cyclic AMP response element-binding protein phosphorylation: Primary role of a b-adrenergic receptor/cyclic AMP mechanism. Molecular Pharmacology 47:439-449.
Schaad, N.C., Vanecek, J., Rodriguez, I.R., Klein, D.C., Holtzclaw, L., and Russell, J.T. (1995) Vasoactive intestinal peptide elevates pinealocyte intracellular calcium concentrations by enhancing influx: Evidence for involvement of a cyclic GMP dependent mechanism. Molecular Pharmacology 47:923-933.
Vanecek, J. and Klein, D.C. (1995) Melatonin inhibition of GnRH-induced LH release from neonatal rat gonadotroph: involvement of Ca++ not cAMP. Am. J. Physiol. 269:E85-E90.
White, B. and Klein, D.C. (1995) Stimulation of cyclic GMP accumulation by sodium nitroprusside is potentiated via a Gs mechanism in intact pinealocytes. Journal of Neurochemistry 64:711-717.
Babila, T., and Klein, D.C. (1994) Cholera toxin-induced Gsa down-regulation in neural tissue: studies on the pineal gland. Brain Research 638:151-156.
Detera-Wadleigh, S.D., Hsieh, W-T., Berrettini, W.H., Goldin, L.R., Rollins, D.Y., Muniec, D., Grewal, R., Guroff, J.J., Turner, G., Coffman, D., Barrick, J., Mills, K., Murray, J., Donohue, S.J., Klein, D.C., et al (1994) Genetic linkage mapping for a susceptibility locus to bipolar illness: Chromosomes 2,3,4,7,9,10p, 11p, 22 and Xpter. Am J Med Genetics 54:206-218.
Lin, A.M.-Y., Schaad, N.C., Schulz, P.E., Coon, S.L., and Klein, D.C. (1994) Pineal nitric oxide synthase: characteristics, adrenergic regulation and function. Brain Research 651:160-168.
Roseboom, P.H., Weller, J.L., Babila, T., Aitken, A., Sellers, L.A., Moffett, J.R., Namboodiri, M.A.A. and Klein, D.C. (1994) Cloning and characterization of the e and z isoforms of the rat 14-3-3 proteins. DNA and Cell Biology 13:629-640. PDF
Vanecek, J. and Klein, D.C. (1994) Mechanism of melatonin action on neonatal rat gonadotrophs. In Advances in Pineal Research, Møller, M., Pévet, P. and Reiter, R.J. (eds), John Libbey (London), Vol. 8, pp. 363-370.
Donohue, S.J., Roseboom, P.H., Illnerova, H., Weller, J.L., and Klein, D.C. (1993) Human hydroxyindole-O-methyltransferase: Presence of LINE-1 fragment in a cDNA clone and pineal mRNA. DNA and Cell Biology 12:715-727.
Klein, D.C.(1993) The mammalian melatonin rhythm generating system. In: Light and Biological Rhythms in Man, Wetterberg, L (ed), Pergamon Press, New York, Vol 63, pp 55-71.
Schaad, N., Korf, H., Parfitt, A., Schaffner, A.E., Russell, J. and Klein, D.C. (1993) Single cell [Ca++]i analysis and biochemical characterization of pinealocytes immobilized with novel attachment peptide preparation. Brain Research 614: 251-256.
Slim, R., Le Paslier, D., Compain, S., Levilliers, J., Ougen, P., Billault, A., Donohue, S.J., Klein, D.C., Mintz, L., Bernheim, A., Cohen, D., Weissenbach, J. and Petit, C. (1993) Construction of a yeast artificial chromosome contig spanning the pseudoautosomal region and isolation of 25 new sequence-tagged sites. Genomics 16:691-697.
Vanecek, J. and Klein, D.C. (1993) A subpopulation of neonatal gonadotrophs is sensitive to melatonin. Endocrinology 133:360-366.
White, B. and Klein, D.C. (1993) Developmental appearance of pineal adrenergic guanosine 3',5'- monophosphate response is determined by a process down-stream from elevation of intracellular Ca2+: Possible involvement of a diffusible factor. Endocrinology 132:1026-1034.
Yi, H., Donohue, S.J., Klein, D.C. and McBride, W. (1993) Localization of the hydroxyindole-O-methyltransferase gene to the pseudoautosomal region: implications for mapping of psychiatric disorders. Human Molecular Genetics 2:127-131.
Yu, L., Schaad, N. and Klein, D.C. (1993) Calcium potentiates cyclic AMP stimulation of pineal N-acetyltransferase (E.C. 2.3.1.87). Journal of Neurochemistry 60:1436-1443.
Babila, T. and Klein, D.C. (1992) Stimulus deprivation increases pineal Gs-alpha and G-beta . Journal of Neurochemistry 59:1356-1362.
Babila, T., Schaad, N., and Klein, D.C. (1992) Development of MEKA, cytosolic G-beta and Santigen in the rat pineal gland and retina. Brain Research 585: 141-148. PDF
Babila, T, Schaad, N., and Klein, D.C. (1992) Rat pineal Gsaalpha, Gibeta and Goa: relative abundance and development. Brain Research 572:232-235. PDF
Donohue, S.J., Roseboom, P.H., and Klein, D.C. (1992) Bovine hydroxyindole-O-methyltransferase: Significant sequence revision. Journal of Biological Chemistry 267:5184-5185.
Huang, S.K., Klein, D.C., and Korf, H. (1992) Immunocytochemical demonstration of rod-opsin, S-antigen,and neuron-specific proteins in the human pineal gland. Cell and Tissue Research 267:493-498.
Klein, D.C., Roseboom, P.H., Donohue, S.J., and Marrs, B.L. (1992) Evolution of melatonin as a night signal: Contribution from a primitive photosynthetic organism. Molecular and Cellular Neuroscience 3:181-183. PDF
Klein, D.C., Schaad, N., Namboodiri, M.A.A., Yu, L., and Weller, J.L. (1992) Regulation of pineal serotonin N-acetyltransferase activity. Biochemical Society Transactions 20:299-304.
Klein, D.C., Schaad, N.C., Yu, L., Babila, T and Ceña, V. (1992) The mammalian melatonin rhythm generating system: Role of calcium and cyclic AMP in the control of serotonin N-acetyltransferase activity. In: Discussions in Neuroscience, M. Zatz (ed) Elsevier vol VIII pp 54-56.
Korf, H.W., White, B.H., Schaad, N.C., and Klein, D.C. (1992) Recoverin in pineal organs and retinae of various vertebrate species including man. Brain Research 595:57-66.
Schaad, N.C. and Klein, D.C. (1992) Characterization of a2-beta-adrenergic receptors of rat pinealocytes. Endocrinology 130:2804-2810.
Vanecek, J. and Klein, D.C. (1992) Melatonin inhibits GnRH stimulation of [Ca++]i in neonatal rat pituitary cells. Endocrinology 130:701-707.
Vanecek, J. and Klein, D.C. (1992) Sodium-dependent effects of melatonin on membrane potential of neonatal rat pituitary cells. Endocrinology 131:939-946.
Weller, J.L. and Klein, D.C. (1992) The pineal adrenergic cyclic GMP response develops two weeks after the adrenergic-cyclic AMP response development. Developmental Brain Research 68:144-147.
Ceña, V., Halperin, J., Yeandle, S. and Klein, D.C. (1991) Norepinephrine stimulates potassium efflux from pinealocytes: Evidence for involvement of biochemical "AND" gate operated by calcium and adenosine 3', 5'-monophosphate. Endocrinology 128:559-569.
Klein, D.C., Moore, R.Y. and Reppert, S.M,eds. (1991) Suprachiasmatic Nucleus: The Mind's Clock. Oxford University Press, NY.
Schaad, N., Shinohara, T. Abe, T. and Klein, D.C. (1991) Photoneural control of the synthesis and phosphorylation of pineal MEKA (phosducin). Endocrinology 129: 3289-3298.
Reig, J.A. and Klein, D.C. (1990) Pineal Transduction: Adrenergic -> cyclic AMP-dependent phosphorylation of cytoplasmic 33-kDa protein (MEKA) which binds bg-complex of transducin. Journal of Biological Chemistry 265:5816-5824. PDF
Shyjan, A.W., Ceña, V., Levenson, R. and Klein, D.C. (1990) Differential expression and enzymatic properties of the Na,K-ATPase alpha-3 isoenzyme in rat pineal glands. Proceedings National Academy Science, USA 87: 1178-1182. PDF
Voisin, P., Harrington, M.G., Weller, J.L., Goldman, D.G., Merrill, C.R. and Klein, D.C. (1990) Noradrenergic control of the synthesis of two rat pineal proteins. Brain Research 517: 25-34.
Abe, T., Yamaki, K., Tsuda, M., Singh, V.K., Suzuki, S., McKinnon, R., Klein, D.C., Donoso, L.A. and Shinohara, T. (1989) Rat pineal S-antigen: Sequence analysis reveals presence of alpha-transducin homologous sequence. FEBS Letters 247: 307-311.
Ho, A.K., Chik, C.L. and Klein, D.C. (1989) Forskolin stimulates pinealocyte cGMP accumulation: Dramatic potentiation by an a1-alpha-adrenergic [Ca2+]i mechanism involving protein kinase C. FEBS Letters 249: 207-212.
Ho, A.K., Chik, C.L., Weller, J.L., Cragoe, E.J. Jr. and Klein, D.C. (1989) Evidence of a1-beta-adrenergic protein kinase C Na+/H+ antiporter dependent increase in pinealocyte intracellular pH: Role in the adrenergic stimulation of cGMP accumulation. Journal of Biological Chemistry 264: 12983-12988.
Korf, H.W., Bruce, J.A., Vistica, B., Rollag, M., Stein, B.M. and Klein, D.C. (1989) Immunoreactive S-antigen in cerebrospinal fluid: A marker of pineal parenchymal tumors? Journal of Neurosurgery 70: 682-687.
McCabe, R.T., Schoenheimer, J.A., Reig, J.A., Klein, D.C., Newman, A.H., Rice, K.C. and Skolnick, P. (1989) [3H]AHN 086 acylates peripheral benzodiazepine receptors in the rat pineal gland. FEBS Letter 244: 263-267.
Nikodijevic, O. and Klein, D.C. (1989) Adenosine stimulates adenosine 3',5'-monophosphate and guanosine 3',5'-monophosphate accumulation in rat pinealocytes: Evidence for a role for adenosine in pineal neurotransmission. Endocrinology 125: 2150-2157.
Chik, C., Ho, A. and Klein, D.C. (1988) a1-alpha-Adrenergic potentiation of vasoactive intestinal peptide stimulation of rat pinealocyte adenosine 3',5'-monophosphate and guanosine 3',5'-monophosphate: Evidence for a role of calcium and protein kinase-C. Endocrinology 122: 702-708.
Chik, C., Ho., A. and Klein, D.C. (1988) Dual receptor regulation of cyclic nucleotides: a1-alpha-adrenergic potentiation of vasoactive intestinal peptide stimulation of pinealocyte adenosine 3',5'-monophosphate. Endocrinology 122: 1646-1651.
Ho., A., Chik, C.L. and Klein, D.C. (1988) Effects of protein kinase inhibitor (1-(5-isoquinolinesulfonyl)-2-methylpiperazine (H7) on protein kinase C activity and adrenergic stimulation of cAMP and cGMP in rat pinealocytes. Biochemical Pharmacology 37: 1015-1020.
Ho, A.K., Chik, C.L. and Klein, D.C. (1988) Permissive role of calcium in a1-alpha-adrenergic stimulation of pineal phosphatidylinositol phosphodiesterase (Phospholipase C) Activity. Journal of Pineal Research 5: 553-564.
Ho, A.K., Thomas, T.P., Chik, C.L., Anderson, W. and Klein, D.C. (1988) Protein kinase C: Subcellular redistribution by increased Ca2+ influx. Journal of Biological Chemistry 263: 9292-9297.
Klein, D.C. (1988) Citation Classic: Commentary on Klein, D.C. and Weller J.L. Indole metabolism in the pineal gland: A circadian rhythm in N-acetyltransferase. Science 169: 1093-1095 (1970) Current Contents 31: 16. PDF
Klein, D.C. (1988) Citation Classic: Commentary on Klein, D.C. and Raisz L.G. Prostaglandins: Stimulation of bone resorption in tissue culture. Endocrinology: 86:1436-1440 (1970) Current Contents 30: 17. PDF
Klein, D.C., Ho, A.K. Chik, C.L. and Weller, J.L. (1988) Adrenergic regulation of pineal cAMP and cGMP: Evidence for a gating mechanism. Catecholamines VI. Part A Dahlstrom (ed) Alan R. Liss, Inc. 71: 415-422.
Klein, D.C., Weller, J.L., Sugden, A.L., Sugden, D., Vanecek, J., Chik, C.L. and Ho, A.K. (1988) Integration of multiple receptor mechanisms regulating pineal cyclic nucleotides. Fundamentals and Clinics in Pineal Research, Trentini, G.P., DeGaetani, C., and Pevet, P. (eds) Raven Press, New York, pp 111-119.
Reig, J.A. and Klein, D.C. (1988) Submicogram quantities of unstained proteins are visualized on polyvinylidene difluoride membranes by transillumination. Journal of Applied and Theoretical Electrophoresis 1: 59-60.
Sugden, D., Ho, A.K., Sugden, A.L. and Klein, D.C. (1988) Negative feedback mechanisms: evidence that desensitization of pineal a1-beta-adrenergic responses involves protein kinase C. Endocrinology 123: 1425-1432.
Sugden, D. and Klein, D.C. (1988) Adrenergic regulation of pinealocyte cyclic GMP. Catecholamine Research, Part A Dahlstrom (ed) Alan R. Liss, Inc. 72: 423-428.
Sugden, D. and Klein, D.C. (1988) Activators of protein kinase C act at a post-receptor site to amplify cAMP production in rat pinealocytes. Journal of Neurochemistry 32: 149-155.
Ceña, V., Gonzalez-Garcia, C., Svoboda, P. and Klein, D.C. (1987) Developmental study of ouabain inhibition of adrenergic induction of rat pineal serotonin N-acetyltransferase (EC 2.3.1.87). Journal of Biological Chemistry 262: 14467-14471.
Chik, C., Ho, A. and Klein, D.C. (1987) Transmembrane receptor cross-talk: concurrent VIP and a1-alpha-adrenergic activation rapidly elevates pinealocyte cGMP > 100-fold. Biochem. Biophys. Res. Comm. 146: 1478-1484.
Chik, C., Ho., A. and Klein, D.C. (1987) Ethanol inhibits dual receptor stimulation of pineal cAMP and cGMP by vasoactive intestinal peptide and phenylephrine. Biochem. Biophys. Res. Commun. 147: 145-151.
Gonzales, C., Ceña, V. and Klein, D.C. (1987) Characterization of the a+alpha-like Na+, K+-ATPase which mediates ouabain inhibition of adrenergic induction of N-acetyltransferase (E.C.2.3.1.87) activity: studies with isolated pinealocytes. Molecular Pharmacology 32: 792-797.
Ho, A.K., Ceña, V. and Klein, D.C. (1987) Cardiac glycosides stimulate phospholipase C activity in rat pinealocytes. Biochemical and Biophysical Research Communications 142: 819-825.
Ho, A., Chik, C. and Klein, D.C. (1987) Protein kinase C is involved in adrenergic stimulation of pineal cGMP accumulation. Journal of Biological Chemistry 262: 10059-10064.
Ho, A.K. and Klein, D.C. (1987) Activation of a1-alpha-adrenoreceptors, protein kinase C, or treatment with intracellular free Ca2+ elevating agents increases pineal phospholipase A2 activity. Journal of Biological Chemistry 262: 11764-11770.
Ho, A.K. and Klein, D.C. (1987) Phosphatidylinositol phosphodiesterase (Phospholipase C) activity in the pineal gland: characterization and photoneural regulation. Journal of Neurochemistry 48: 1033-1038.
Klein, D.C., Vanecek, J., Ho, A.K., Sugden, A.L. and Sugden, D. (1987) a1- alpha and 1 -beta-adrenergic regulation of pineal cyclic AMP and cyclic GMP. In: Magistretti, P.J., Morrison, J.H., Reisine, T.D., Axelrod, J. and Bloom, F. (eds) Discussions in Neurosciences III: Transduction of Neuronal Signals (pp 151-160).
Namboodiri, M.A.A., Brownstein, M.J., Voisin, P., Weller, J.L. and Klein, D.C. (1987) A simple and rapid method for the purification of ovine pineal arylalkylamine N-acetyltransferase. Journal of Neurochemistry 48: 580-585. PDF
Namboodiri, M.A.A., Brownstein, M., Weller, J.L., Voisin, P. and Klein, D.C. (1987) Multiple forms of arylamine N-acetyltransferase in the rat pineal gland: Purification of one molecular form. Journal of Pineal Research 4: 235-246. PDF
Sugden, D. and Klein, D.C. (1987) A cholera toxin substrate regulates cyclic GMP content of rat pinealocytes. Journal of Biological Chemistry 262: 7447-7450.
Sugden, D. and Klein, D.C. (1987) Inactivation of rat pineal hydroxyindole-O-methyltransferase by disulfide-containing compounds. Journal of Biological Chemistry 262: 6489-6493.
Sugden, A.L., Sugden, D. and Klein, D.C. (1987) a1-alpha-adrenoceptor activation elevates cytosolic calcium in rat pinealocytes by increasing net influx. Journal of Biological Chemistry 262: 741-745.
Yanovski, J., Witcher, J., Adler, N., Markey, S. and Klein, D.C. (1987) Stimulation of the paraventricular nucleus area of the hypothalamus elevates urinary 6-hydroxymelatonin during daytime. Brain Research Bulletin 19: 129-133. PDF
Basile, A., Klein, D.C. and Skolnick, P. (1986) Characterization of benzodiazepine receptors in the bovine pineal gland: evidence for the presence of an atypical binding site. Molecular Brain Research 1: 127-135.
Ho, T., Somers, R. and Klein, D.C. (1986) Development and regulation of rhodopsin kinase in rat pineal and retina. Journal of Neurochem. 46: 1176-1179. PDF
Klein, D.C., Sugden, D., Vanecek, J., Thomas, T. and Anderson, W. (1986) Phospholipid-protein kinase C involvement in the adrenergic regulation of pinealocyte cyclic AMP: A model of how modulations act? In L.A. Horrocks, I. Freysz and G. Toffano. Fidia Research Series 4 Phospholipids in the Nervous system: Molecular and pharmacological aspects. Liviana Press, Padova pp 113-120.
Korf, H., Klein, D.C., Zigler, S., Gery, I. and Schachenmayer, W. (1986) S-Antigen-like immunoreactivity in a human pineocytoma. Acta. Neuropathologica 69: 165-167.
Korf, H., Oksche, A., Ekstrom, P., Gery, I., Zigler, J.S. and Klein, D.C. (1986) Pinealocyte projections into the mammalian brain revealed with S-antigen antiserum. Science 231: 735-737.
Korf, H.W., Oksche, A., Ekström, P., van Veen, T., Zieler, J.S., Gery, I., Stein, P. and Klein, D.C. (1986) S-Antigen immunocytochemistry. In: Pineal and Retinal Relationships. O'Brien, P.J. and Klein, D.C. (eds) Academic Press, Orlando, pp 343-355. PDF
Namboodiri, M.A.A., Dubbels, R. and Klein, D.C. (1986) Arylalkylamine N-acetyltransferase from mammalian pineal gland. Methods in Enzymology 142: 583-590.
Namboodiri, M.A.A. and Klein, D.C. (1986) Multiple aromatic amine N-acetyltransferases in the pineal gland. In Pineal and Retinal Relationships (eds. P.J. O'Brien and D.C. Klein) Academic Press, Orlando, pp 133-150. PDF
Santer, D., Heydorn, W., Creed, J., Klein, D.C. and Jacobowitz, D. (1986) Subfornical organ: Effects on individual proteins. Brain Research Bulletin 372: 107-114.
Shinohara, T., Craft, C.M., Stein, P., Ziegler Jr., J.S., Wistow, G., Katial, A., Gery, I. and Klein, D.C. (1986) Isolation of cDNAs for bovine S-antigen. In: Pineal and Retinal Relationships. P.J. O'Brien and D.C. Klein (eds.) Academic Press, Orlando pp 331-343.
Sugden, D., Ceña, V. and Klein, D.C. (1986) Hydroxyindole-O-methyltransferase. Methods in Enzymology 142: 590-596.
Sugden, D. and Klein, D.C. (1986) Adrenergic regulation of pineal cyclic AMP and cyclic GMP in rat pinealocytes. In Pineal and Retinal Relationships (eds. P.J. O'Brien and D.C. Klein) Academic Press, Orlando pp 293-305.
Sugden, A.L., Sugden, D. and Klein, D.C. (1986) Essential role of calcium influx in the adrenergic regulation of cAMP and cGMP in rat pinealocytes. Journal of Biological Chemistry 261: 11608-11612.
Sugden, D., Voisin, P. and Klein, D.C. (1986) Purification of rat HIOMT. Journal of Pineal Research 3: 389-395.
van Veen, T., Elofsson, R., Hartwig, H.G., Gery, I., Mochizuki, M. and Klein, D.C. (1986) Retinal S-antigen: Immunocytochemical and immunochemical studies on distribution in animal photoreceptors and pineal organs. Experimental Biology 45: 15-25.
van Veen T., Ostholm, T., Giershick, P., Spiegel, A., Somers, R., Korf, H.W. and Klein, D.C. (1986) alpha-Transducin immunoreactivity in retinae and sensory pineal organs of adult vertebrates. Proc. Natl. Acad. Sci. U.S.A. 83: 912-916.
Vanecek, J., Sugden, D., Weller, J. and Klein, D.C. (1986) See-saw signal processing in pinealocytes involves reciprocal changes in the 1-alpha-adrenergic component of the cyclic GMP response and the beta adrenergic component of the cyclic AMP responses. Journal of Neurochemistry 47: 678-686.
Brightman, M.W., Markey, S.P. and Klein, D.C. (1985) Cotransplants of pineal gland and superior cervical ganglion to the IV ventricle. Transplantation in the Mammalian CNS: An Erick Fernstrom Symposium. eds. A. Bjorklund, U., Stenevi and A. Aguayo. Elsevier, Amsterdam 235-241.
Klein, D.C. (1985) Photoneural regulation of the mammalian pineal gland. (ed) D. Evered and S. Clark. In: Photoperiodism, Melatonin and the Pineal. Pitman, London (Ciba Foundation Symposium 117) p 38-56.
Klein, D.C., Namboodiri, M.A.A. and Voisin, P. (1985) The pineal family of aromatic amine N-acetyltransferases. Bioassays 3: 217-219.
Korf, H., Moller, M., Gery, I., Zigler, S. and Klein, D.C. (1985) Immunocytochemical demonstration of retinal S-antigen in the pineal organ of four mammalian species. Cell and Tissue Research 239: 81-85.
Namboodiri, M.A.A., Sugden, D., Klein, D.C., Grady, R. and Mefford, I.N. (1985) Rapid nocturnal increase in ovine pineal N-acetyltransferase activity and melatonin synthesis: Effects of cycloheximide. Journal of Neurochemistry 45: 832-835. PDF
Namboodiri, M.A.A., Sugden, D., Klein, D.C., Tamarkin, L. and Mefford, I.N. (1985) Serum melatonin and pineal indoleamine metabolism in a species with a small day/night N-acetyltransferase rhythm. Journal of Comparative Biochemistry 80B: 731-736.
Sugden, D. and Klein, D.C. (1985) Development of the rat pineal a1-alpha-adrenoceptor. Brain Research 325: 345-348. PDF
Sugden, D., Namboodiri, M.A.A., Klein, D.C. and Mefford, I.N. (1985) Ovine pineal indoles: Effects of L-tryptophan or L-5-hydroxytryptophan administration. Journal of Neurochemistry 44: 769-772.
Sugden, D., Namboodiri, M.A.A., Klein, D.C., Pierce, J.E., Grady, R.K., Jr. and Mefford, I. (1985) Ovine pineal a1-adrenoreceptors: Characterization and evidence for a functional role in the regulation of serum melatonin. Endocrinology 116: 1960-1967.
Sugden, D., Vanecek, J., Klein, D.C., Thomas, T.P. and Anderson, W.B. (1985) Activation of protein kinase C potentiates isoprenaline-induced cyclic AMP accumulation in rat pinealocytes. Nature 314: 359-361.
Vanecek, J., Sugden, D., Weller, J.L. and Klein, D.C. (1985) Atypical synergistic 1-alpha-and beta-adrenergic regulation of adenosine 3',5'-monophosphate and guanosine 3',5'- monophosphate in rat pinealocytes. Endocrinology 116: 2167-2173.
Gold, M., Heydorn, W., Creed, G.J., Weller, J.L., Klein, D.C. and Jacobowitz, D.M. (1984) In Vitro [35S]methionine labeled protein in microdissected discrete brain areas: Marked regional differences revealed by two-dimensional gel electrophoresis. Electrophoresis 5: 116-121.
Klein, D.C. (1984) Melatonin and puberty. Science 224: 6.
Klein, D.C., Sugden, D., Voisin, P., Vanecek, J. (1984) The mammalian melatonin rhythm generating system in Endocrinology, Proceedings of the VIII International Congress, F. Labrie, and L. Prouix (Eds.) Elsevier Science Publishers B.V., Amsterdam, pp. 135-138.
Matthew, E., Parfitt, A.G., Sugden, D., Engelhardt, D.L., Zimmerman, E.A. and Klein, D.C. (1984) Benzodiazepines: Rat pinealocyte binding sites and augmentation of norepinephrine-stimulation of N-acetyltransferase activity. J. Pharm. and Exp. Ther. 228: 434-438.
Reppert, S., Perlow, M., Artman, H., Ungerleider, L., Fisher, D., Mishkin, M. and Klein, D.C. (1984) The circadian rhythm of oxytoxin in primate cerebrospinal fluid: Effects of destruction of the suprachiasmatic nuclei. Brain Research 307: 384-387.
Rollag, M., Welsh, M.G. and Klein, D.C. (1984) Effect of acute light exposure upon melatonin content, NAT activity, and nuclear volume in the gerbil pineal complex. Pineal Research 1: 339-347.
Somers, R.L. and Klein, D.C. (1984) Rhodopsin kinase activity in the mammalian pineal gland and other tissues. Science 226: 182-184.
Sugden, D. and Klein, D.C. (1984) Regulation of rat pineal 1-alpha-adrenoceptors. Journal of Neurochemistry 44: 63-67.
Sugden, D. and Klein, D.C. (1984) Rat pineal alpha1-adrenoceptors: Identification and characterization using [125I]-iodo-2-[betaβ-(4-hydroxyphenyl)-ethylaminomethyl]tetralone ([125I]HEAT). Endocrinology 114: 435-440.
Sugden, D., Weller, J.L., Klein, D.C., Kirk, K.L. and Creveling, C.R. (1984) Alpha-adrenergic potentiation of beta-adrenergic stimulation of rat pineal N-acetyltransferase: Studies using cirazoline and fluorine analogs of norepinephrine. Biochem. Pharm. 33: 3947-3950.
Voisin, P., Namboodiri, M.A.A. and Klein, D.C. (1984) Arylamine N-acetyltransferase and arylalkylamine N-acetyltransferase in the mammalian pineal gland. Journal of Biological Chemistry 259: 10913-10918. PDF
Weissman, B.A., Skolnick, P. and Klein, D.C. (1984) Regulation of "Peripheral-type" binding sites for benzodiazepines in the pineal gland. Biochemistry and Behavior 21: 821-824.
Kapatos, G., Kaufman, S., Weller, J.L. and Klein D.C. (1983) The development of tetrahydrobiopterin and guanosine-5'-triphosphate cyclohydrolase: differential patterns in rat brain and pineal gland. Brain Research 258: 351-355. PDF
Klein, D.C. (1983) Converging circadian rhythms could explain effects of the pineal gland: Implications for psychiatric disease in Circadian Rhythms in Psychiatry. Wehr, T.A. and Goodwin, F.K. (Eds.) The Boxwood Press, pp. 221-233.
Klein, D.C., Smoot, R., Weller, J.L., Higa, S., Markey, S.P., Creed, G.J. and Jacobowitz, D.M. (1983) Lesions of the paraventricular nucleus area of the hypothalamus disrupt the suprachiasmatic spinal cord circuit in the melatonin rhythm generating system. Brain Research Bulletin 10: 647-652. PDF
Klein, D.C., Sugden, D. and Weller, J.L. (1983) Postsynaptic alpha-adrenergic receptors potentiate the beta-adrenergic stimulation of pineal serotonin N-acetyltransferase. Proc. Natl. Acad. Sci. 80: 599-603.
Klein, D.C., Wheler, G.H.T. and Weller, J.L. (1983) Taurine in the pineal gland in Sulfur Amino Acids: Biochemical and Clinical Aspects. Kuriyama, K., Huxtable, R.J. and Iwata, H. (Eds.) Alan R. Liss, Inc., New York, NY, pp. 169-181.
Mefford, I.N., Chang, P., Klein, D.C., Namboodiri, M.A.A., Sugden, D. and Barchas, J. (1983) Reciprocal day/night relationship between serotonin oxidation and N-acetylation products in the rat pineal gland. Endocrinology 113: 1582-1586.
Namboodiri, M.A.A., Sugden, D., Klein, D.C. and Mefford, I. (1983) 5-Hydroxytryptophan elevates serum melatonin. Science 221: 659-661.
Namboodiri, M.A.A., Sugden, D., Mefford, I.N. and Klein, D.C. (1983) Melatonin and related compounds. In "Methods in Biogenic Amine Research" (eds. Parvez, H., Parvez, S. and Nagatsu, T.) Elsevier/North Holland Biomedical Press, Amsterdam, Netherlands, pp. 549-565.
Sugden, D. and Klein, D.C. (1983) beta-Adrenergic receptor control of rat pineal hydroxyindole-O-methyltransferase. Endocrinology 113: 348-353.
Sugden, D. and Klein, D.C. (1983) Regulation of rat pineal hydroxyindole-O-methyltransferase in neonatal and adult rats. J. Neurochem. 40: 1647-1653. PDF
Sugden, D. and Klein, D.C. (1983) Adrenergic stimulation of rat pineal hydroxyindole-O-methyltransferase. Brain Research 265: 348-351.
Sugden, D., Namboodiri, M.A.A., Weller, J.L. and Klein, D.C. (1983) Melatonin synthesizing enzymes: Serotonin N-acetyltransferase and hydroxyindole-O-methyltransferase. In "Methods in Biogenic Amine Research" (eds. Parvez, H., Parvez, S. and Nagatsu, T.) Elsevier/North Holland Biomedical Press, Amsterdam, Netherlands, pp. 567-572.
Kapatos, G., Kaufman, S., Weller, J.L., and Klein, D.C. (1982) Development and regulation of biopterin in the pineal gland of the rat in Melatonin Rhythm Generating System: Developmental Aspects. Klein, D.C. (Ed.) Karger, Basel, pp. 108-123.
Kapatos, G., Kaufman, S., Weller, J.L. and Klein, D.C. (1982) Adrenergic-cyclic AMP regulation of biopterin biosynthesis in the pineal gland in Monoamine Enzymes. Weiner, N., Usdin, E. and Youdim, M. (Eds.) MacMillan Publishers Ltd., London, England, pp. 231-240.
Klein, D.C. (1982) (ed.) The Melatonin Rhythm Generating System: Developmental Aspects. Kargar Press, Basal.
Klein, D.C. and Namboodiri, M.A.A. (1982) Inactivation of pineal N-acetyltransferase by disulfide exchange: A possible role of S-S peptides in Monoamine Enzymes. Weiner, N., Usdin, E. and Youdim, M. (Eds.) MacMillan Publishers Ltd., London, England, pp. 711-772.
Klein, D.C. and Namboodiri, M.A.A. (1982) Control of the circadian rhythm in pineal serotonin N-acetyltransferase activity: possible role of protein thiol:disulfide exchange. Trends in Biochemical Science 7: 98-102.
Namboodiri, M.A., Favilla, J. and Klein, D.C. (1982) Activation of pineal acetyl coenzyme A hydrolase by disulfide peptides. J. Biol. Chem. 257: 10030-10032.
Namboodiri, M.A.A. and Klein, D.C. (1982) Purification of sheep pineal N-acetyltransferase in Monoamine Enzymes. Weiner, N., Usdin, E. and Youdim, M. (Eds.) MacMillan Publishers Ltd., London, England, pp. 701-710.
Auerbach, D.A. (1981) b-Adrenergic receptors during development. Melatonin Rhythm Generating System. Int. symp., Bethesda, Md., pp. 97-107. PDF
Auerbach, D., Klein, D.C., Kirk, K., Cantacuzene, D. and Creveling, C.R. (1981) Effects of fluorine analogs of norepinephrine on stimulation of cyclic adenosine 3',5' monophosphate and binding to beta-adrenergic receptors in intact pinealocytes. Biochem. Pharm. 30: 1085-1089.
Auerbach, D.A., Klein, D.C., Woodard, B. and Aurbach, G.D. (1981) Neonatal rat pinealocytes: Typical and atypical characteristics of 125I-indohydroxybenzylpindolol binding and adenosine 3',5'-monophosphate accumulation. Endocrinology 108: 559-567.
Kapatos, G., Kaufman, S., Weller, J.L. and Klein, D.C. (1981) Biosynthesis of Biopterin: Adrenergic cyclic adenosine monophosphate-dependent inhibition in the pineal gland. Science 213: 1129-1131.
Klein, D.C., Auerbach, D., Namboodiri, M.A.A. and Wheler, G.H.T. (1981) Indole metabolism in the mammalian pineal gland. In: Pineal Gland: I. Anatomy and Biochemistry. Reiter, R. (Ed.) CRC Press, pp. 199-227.
Klein, D.C., Auerbach, D. and Weller, J.L. (1981) Seesaw signal processing in pineal cells: Homologous sensitization of adrenergic stimulation of cyclic GMP accompanies homologous desensitization of b-beta-adrenergic stimulation of cyclic AMP. Proc. Natl. Acad. Sci. USA 78: 4625-4629.
Klein, D.C., Namboodiri, M.A.A. and Auerbach, D.A. (1981) The melatonin rhythm generating system: Developmental aspects. Life Sciences 28: 1975-1986. PDF
Namboodiri, M.A.A., Favilla, J.T. and Klein, D.C. (1981) Pineal N-acetyltransferase is inactivated by disulfide-containing peptides: Insulin is the most potent. Science 213: 571-573.
Perlow, M.J., Reppert, S.M., Boyar, R.M. and Klein, D.C. (1981) Daily rhythms in cortisol and melatonin in primate cerebrospinal fluid: Effect of constant light and dark. Neuroendocrinology 32: 193-196.
Reppert, S.M. (1981) Maternal melatonin: A source of melatonin for the immature mammal. Melatonin Rhythm Generating System. Int. Symp., Bethesda, Md., pp. 182-192. PDF
Reppert, S.M., Perlow, M.J., Tamarkin, L., Orloff, D. and Klein, D.C. (1981) The effects of environmental lighting on the daily melatonin rhythm in primate cerebrospinal fluid. Brain Research 223: 313-323.
Reppert, S.M., Perlow, M.J., Ungerleider, L., Mishkin, M., Tamarkin, L., Orloff, D.G., Hoffman, H. and Klein, D.C. (1981) Effects of damage to the suprachiasmatic area of the anterior hypothalamus on the daily melatonin and cortisol rhythms in the Rhesus monkey. J. of Neurosciences 1: 1414-1425.
Wheler, G.H.T. and Klein, D.C. (1981) Function and regulation of taurine in the pineal gland. In: Effects of Taurine in Excitable Tissues. Schaffer, S.W., Baskin, S.I. and Kocsis, J.J. (Eds.) S.P. Medical and Scientific Books, New York, pp. 107-121.
Klein, D.C., Weller, J.L., Auerbach, D. and Namboodiri, M.A.A. (1980) Regulation of pineal N-acetyltransferase: Focus on "turn-off". In: Enzymes and Neurotransmitters in Mental Disease. Usdin, E., Sourkes, T.L. and Youdim, M.B. (Eds.), pp. 603-627.
Martin, J.E., Kirk, K.L. and Klein, D.C. (1980) Effects of 6-Hydroxy-, 6-fluoro-, and 4,6-difluoromelatonin on the in vitro pituitary response to luteinizing hormone-releasing hormone. Endocrinology 106: 398-401.
Namboodiri, M.A.A., Weller, J.L. and Klein, D.C. (1980) Rapid and reversible activation of acetyl CoA hydrolase in intact pineal cells by disulfide exchange. Biochemical and Biophysical Research Communications 96: 188-195.
Namboodiri, M.A.A., Weller, J.L. and Klein, D.C. (1980) Evidence of inactivation of pineal indoleamine N-acetyltransferase by protein thiol-disulfide exchange. J. Biol. Chem. 255: 6032-6035.
Perlow, M.J., Reppert, S.M., Tamarkin, L., Wyatt, R. and Klein, D.C. (1980) Photic regulation of melatonin: Man and monkey are not the same. Brain Research 182: 211-216.
Reppert, S.M. and Klein, D.C. (1980) Mammalian pineal gland: Basic and clinical aspects. In: Endocrine Function of the Brain. Motta, M. (Ed.) Raven Press, New York, pp. 327-371.
Reppert, S.M., Perlow, M. and Klein, D.C. (1980) Cerebrospinal fluid melatonin. In: Neurobiology of CSF. Wood, J.H. (Ed.) Plenum Publishers, pp. 579-589.
Tamarkin, L., Reppert, S.M., Klein, D.C., Pratt, B. and Goldman, B.P. (1980) Studies on the daily pattern of pineal melatonin in the Syrian hamster. Endocrinology 107: 1525-1529.
Tamarkin, L., Reppert, S.M., Orloff, D.J., Klein, D.C., Yellon, S.M. and Goldman, B.D. (1980) Ontogeny of the pineal melatonin rhythm in the Syrian (Mesacricetus auratus) and Siberian (Phodopus sungorus) hamsters and in the rat. Endocrinology 107: 1061-1064.
Wheler, G.H.T. and Klein, D.C. (1980) Taurine release from the pineal gland is stimulated by a beta-adrenergic mechanism. Brain Research 187: 155-164.
Klein, D.C. (1979) Circadian rhythms in the pineal gland. In: Endocrine rhythms. Kreiger, D. (Ed.) Raven Press, New York, pp. 203-223.
Klein, D.C. and Moore, R.Y. (1979) Pineal N-acetyltransferase and hydroxyindole-O-methyltransferase: control by the retinohypothalamic tract and the suprachiasmatic nucleus. Brain Research 174: 245-262. PDF
Kvetnansky, R., Kopin, I. and Klein, D.C. (1979) Stress increases pineal epinephrine. Commun. in Psychopharm. 3: 69-72.
Martin, J.E., McKellar, S. and Klein, D.C. (1979) Melatonin inhibition of the in vivo pituitary response to luteinizing hormone-releasing hormone in ne of Neurochemistry 33: 807-810.
Namboodiri, M.A.A., Namboodiri, M.A., Weller, J.L. and Klein, D.C. (1979) A comparative study of pineal acetyl-CoA hydrolase and N-acetyltransferase activities. Journal of Neurochemistry 32: 31-33.
Reppert, S.M., Chez, R.A., Anderson, A. and Klein, D.C. (1979) Maternal-fetal transfer of melatonin in the non-human primate. Pediatric Research 13: 788-791.
Reppert, S.M., Perlow, M.J., Tamarkin, L. and Klein, D.C. (1979) A diurnal melatonin rhythm in primate cerebrospinal fluid. Endocrinology 104: 295-301.
Tamarkin, L., Reppert, S.M. and Klein, D.C. (1979) Regulation of pineal melatonin in the Syrian hamster. Endocrinology 104: 385-389.
Wheler, G.H.T. and Klein, D.C. (1979) Cyclic AMP-induced release of [14C] taurine from pinealocytes. Biochemical and Biophysical Research Communications 90: 22-27.
Wheler, G.H.T., Weller, J.L. and Klein, D.C. (1979) Taurine: Stimulation of pineal N-acetyltransferase activity and melatonin production via a beta-adrenergic mechanism. Brain Research 166: 65-74.
Buda, M. and Klein, D.C. (1978) A suspension culture of pinealocytes: Regulation of N-acetyltransferase activity. Endocrinology 103: 1483-1493.
Buda, M. and Klein, D.C. (1978) Function and regulation of pineal N-acetyltransferase. In: Biochemistry and function of amine enzymes. Usdin, E., Weiner, N. and Youdim, M. (Eds.) M. Dekker, New York, pp. 545-555.
Buda, M. and Klein, D.C. (1978) N-acetylation of biogenic amines. In: Biochemistry and function of amine enzymes. Usdin, E., Weiner, N. and Youdim, M. (Eds.) M. Dekker, New York, pp. 527-544.
Klein, D.C. (1978) The pineal gland: A model of neuroendocrine regulation. In: The Hypothalamus. Reichlin, S., Baldessarini, R.J. and Martin, B. (Eds.) Raven Press, New York, pp. 303-327.
Klein, D.C., Buda, M., Kapoor, C. and Krishna, G. (1978) Pineal serotonin N-acetyltransferase activity: Abrupt decrease in adenosine 3', 5'-monophosphate may be signal for "turnoff". Science 199: 309-311. PDF
Klein, D.C. and Martin, J. (1978) Direct effects of pineal indoles on the pituitary response to luteinizing hormone-releasing hormone. In: Sexual Endocrinology. Vokaer, R. and DeMabeuge, R. (Eds.) Masson Publishing Inc., New York, 12: 175-184.
Reppert, S. and Klein, D.C. (1978) Transport of maternal [3H]melatonin to suckling rats and the fate of [3H]melatonin in the neonatal rat. Endocrinology 102: 582-588.
Klein, D.C., Weller, J.L., Kirk, K.L. and Hartley, R.W. (1977) Incorporation of 2-fluoro-L-histidine into cellular protein. Molecular Pharmacology 13: 1105-1110.
Martin, J.E., Engel, J.N. and Klein, D.C. (1977) Inhibition of the in vitro pituitary response to luteinizing hormone-releasing hormone by melatonin, serotonin, and 5-methoxytryptamine. Endocrinology 100: 675-680.
Parfitt, A. and Klein, D.C. (1977) Increase caused by desmethylimipramine in the production of [3H] melatonin by isolated pineal glands. Biochemical Pharmacology 26: 904-905. PDF
Yuwiler, A., Klein, D.C., Buda, M and Weller, J.L. (1977) Adrenergic control of pineal N-acetyltransferase activity: Developmental aspects. American Journal of Physiology 233(3): E141-E146.
Binkley, S., Klein, D.C. and Weller, J.L. (1976) Pineal serotonin N-acetyltransferase activity: Protection of stimulated activity by acetyl-CoA and related compounds. Journal of Neurochemistry. 26: 51-55. PDF
Chen, C.H., Klein, D.C. and Robinson, J.C. (1976) Monoamine oxidase in rat placenta, human placenta, and cultured choriocarcinoma. Journal of Reproduction and Fertility 46: 477-479.
Chiou, C.Y., Trzeciakowski, J. and Klein, D.C. (1976) Histamine mediation of nicotine effects on postganglionic sympathetic junctions. Neuropharmacology 15: 689-693.
Klein, D.C. (1976) Pineal function: Control of circadian rhythms. In: Excerpta Medica International Congress Series No 402. Endocrinology Proceedings of the V International Congress of Endocrinology, Hamburg, July 18-24, 1976, Volume I James, V.H.T. (Ed) pp. 72-76.
Klein, D.C. and Kirk, K.L. (1976) 2-Fluoro-L-Histidine: A histidine analog which inhibits enzyme induction. Symposium on Biochemistry Involving Carbon-Fluorine Bonds. Washington, D.C., ACS Symposium Series No. 28, pp. 35-56.
Klein, D.C., Kirk, K.L., Weller, J.L., Oka, T., Parfitt, A. and Owens, I. (1976) 2-Fluoro-L-Histidine, an inhibitor of enzyme induction. Molecular Pharmacology 12: 720-730.
Klein, D.C. and Parfitt, A. (1976) A protective role of nerve endings in the stress-stimulated increase in pineal N-acetyltransferase activity. In: Catecholamines and Stress. Kvetnansky, R. and Usdin, E. (Eds.) Pergamon Press, New York, pp. 119-128. PDF
Martin, J.E. and Klein, D.C. (1976) Melatonin inhibition of the neonatal pituitary response to luteinizing hormone-releasing factor. Science 191: 301-302. PDF
Martin, J.E. and Klein, D.C. (1976) Long-term organ culture of rat anterior pituitary glands. Endocrinology 99: 1189-1198.
Mata, M.M., Schrier, B.K., Klein, D.C., Weller, J.L. and Chiou, C.Y. (1976) On GABA function and physiology in the pineal gland. Brain Research 118: 383-394.
Parfitt, A.G. and Klein, D.C. (1976) Sympathetic nerve endings in the pineal gland protect against acute stress-induced increase in N-acetyltransferase (E.C. 2.3.1.5) activity. Endocrinology 99: 840-851. PDF
Parfitt, A., Weller, J.L. and Klein, D.C. (1976) Beta adrenergic blockers decrease adrenergically stimulated N-acetyltransferase activity in pineal glands in organ culture. Neuropharmacology 15: 353-358.
Binkley, S.A., MacBride, S., Klein, D.C. and Ralph, C.L. (1975) Regulation of pineal rhythms in chickens: Refractory period and nonvisual light perception. Endocrinology 96: 848-853.
Klein, D.C. and Parfitt, A. (1975) Ouabain blocks the adrenergic cyclic AMP stimulation of pineal N-acetyltransferase activity. In: Cyclic Nucleotides in Disease. Weiss, B. (Ed.) University Park Press, Baltimore, Maryland, pp 257-265.
Klein, D.C., Weller, J.L., Parfitt, A. and Kirk, K.L. (1975) 2-Fluoro-L-Histidine: An incorporated inhibitor of the adrenergic stimulation of pineal N-acetyltransferase activity. In: Catecholamine Research. Vol. II. Almgren, O., Carlsson, A. and Engel, J. (Eds.) North-Holland, New York, pp. 293-300.
Parfitt, A., Weller, J.L., Klein, D.C., Sakai, K.K. and Marks, B.H. (1975) Blockade by ouabain or elevated potassium ion concentration of the adrenergic and adenosine cyclic 3',5'-monophosphate-induced stimulation of pineal serotonin N-acetyltransferase activity. Molecular Pharmacology 11: 241-255.
Ralph, C., Binkley, S.A., MacBride, S. and Klein, D.C. (1975) Regulation of pineal rhythms in chickens: Effects of blinding, constant light, constant dark, and superior cervical ganglionectomy. Endocrinology 97: 1373-1378. PDF
Bensinger, R.E., Klein, D.C., Weller, J.L. and Lovenberg, W.M. (1974) Radiometric assay of total trytophan hydroxylation by intact cultured pineal glands. Journal of Neurochemistry. 23: 111-117.
Chen, C., Klein, D.C. and Robinson, J.C. (1974) Catechol-O-methyltransferase in rat placenta, human placenta and choriocarcinoma grown in culture. Journal of Reproduction and Fertility 39: 407-410.
Klein, D.C. (1974) Circadian rhythms in indole metabolism in the rat pineal gland. In: The Neurosciences; Third Study Program. Schmitt, F.O. and Worden, F.G. (Eds.) MIT Press, Cambridge, Massachusetts, pp. 509-515. PDF
Klein, D.C. and Yuwiler, A. (1974) Beta-adrenergic regulation of indole metabolism in the pineal gland. In: Frontiers in Catecholamines. Pergamon Press, New York, pp. 321-325.
Moore, R.Y. and Klein, D.C. (1974) Visual pathways and the central neural control of a circadian rhythm in pineal serotonin N-acetyltransferase activity. Brain Research 71: 17-33. PDF
Schrier, B. and Klein, D.C. (1974) Absence of choline acetyltransferase in rat and rabbit pineal gland. Brain Research 79: 347-351.
Ulrich, R., Yuwiler, A., Wetterberg, L. and Klein, D.C. (1974) Effects of light and temperature on the pineal gland in suckling rats. Neuroendocrinology 13: 255-263.
Vaughan, M.L., Vaughan, G.M. and Klein, D.C. (1974) Arginine Vasotocin: Effects on the development of reproductive organs. Science 168: 938-939.
Binkley, S., Klein, D.C. and Weller, J.L. (1973) Dark induced increase in pineal serotonin N-acetyltransferase activity: A refractory period. Experientia 29: 1339-1340.
Binkley, S.A., MacBride, S., Klein, D.C. and Ralph, C.L. (1973) Pineal enzymes: Regulation of avian melatonin synthesis. Science 181: 273-275. PDF
Coyle, J.T., Jacobowitz, D., Klein, D.C. and Axelrod, J. (1973) Dopaminergic neurons in explants of substantia nigra in culture. Neurobiology 4: 461-470.
Klein, D.C. (1973) The role of serotonin N-acetyltransferase in the adrenergic regulation of indole metabolism in the pineal gland. In: Serotonin and Behavior. Barchas, J. and Usdin, E. (Eds.) Academic Press, New York, pp. 109-119.
Klein, D.C. and Weller, J.L. (1973) Adrenergic-adenosine 3',5'-monophosphate regulation of serotonin N-acetyltransferase activity and the temporal relationship of serotonin N-acetyltransferase activity to synthesis of 3H-N-acetylserotonin and 3H-melatonin in the cultured rat pineal gland. J. Pharmacol. Exp. Ther. 186: 516-527. PDF
Klein, D.C., Yuwiler, A., Weller, J.L. and Plotkin, S. (1973) Postsynaptic adrenergic-cyclic AMP control of the serotonin content of cultured rat pineal glands. Journal of Neurochemistry 21: 1261-1271.
Berg, G.R. and Klein, D.C. (1972) Norepinephrine increases the [32P] labelling of a phospholipid fraction of postsynaptic pineal membranes. Journal of Neurochemistry 19: 2519-2532.
Ellison, N., Weller, J.L. and Klein, D.C. (1972) Development of a circadian rhythm in the activity of pineal serotonin N-acetyltransferase. Journal of Neurochemistry 19: 1335-1341. PDF
Klein, D.C. (1972) Evidence for the placental transfer of 3H-acetyl-melatonin. Nature 237: 117-118.
Klein, D.C. (1972) Melatonin synthesis. In: The Thyroid and Biogenic Amines. Rall, J.E. and Kopin, I.J. (Eds.) North-Holland Publishing Co., Amsterdam, pp. 550-568.
Klein, D.C. and Weller, J.L. (1972) Rapid light-induced decrease in pineal serotonin N-acetyltransferase activity. Science 177: 532-533. PDF
Lott, I., Quarles, R.H. and Klein, D.C. (1972) Biosynthesis and release of glycoproteins by pineal gland in organ culture. Biophysica Biochimica Acta 264: 144-151.
Silberstein, S.D., Lemberger, L., Klein, D.C., Axelrod, J. and Kopin, I. (1972) Induction of adrenal tyrosine hydroxylase in organ culture. Neuropharmacology 11: 721-726.
Strada, S., Klein, D.C., Weller, J.L. and Weiss, B. (1972) Effect of norepinephrine on the concentration of adenosine 3',5'-monophosphate of rat pineal gland in organ culture. Endocrinology 90: 1470-1475.
Berg, G.R. and Klein, D.C. (1971) Non-cartesian pineal function. New England Journal of Medicine 284: 332.
Berg, G.R. and Klein, D.C. (1971) Pineal gland in organ culture. II. Role of adenosine 3',5'-monophosphate in the regulation of radiolabelled melatonin production. Endocrinology 89: 453-464.
Klein, D.C. and Raisz, L.G. (1971) Role of adenosine-3',5'-monophosphate in the hormonal regulation of bone resorption: Studies with cultured fetal bone. Endocrinology 89: 818-826.
Klein, D.C., Reiter, R.J. and Weller, J.L. (1971) Pineal N-acetyltransferase activity in blinded and anosmic male rats. Endocrinology 89: 1020-1023.
Klein, D.C., Weller, J.L. and Moore, R.Y. (1971) Melatonin metabolism: Neural regulation of pineal serotonin:acetyl coenzyme A N-acetyltransferase activity. Proceedings of the National Academy of Sciences, U.S.A. 68: 3107-3110. PDF
Reiter, R.J. and Klein, D.C. (1971) Observations on the pineal glands, the Harderian glands, the retina, and the reproductive organs of adult female rats exposed to continuous light. Journal of Endocrinology 51: 117-125.
Klein, D.C. and Berg, G.R. (1970) Pineal gland: Stimulation of melatonin production by norepinephrine involves cyclic AMP mediated stimulation of N-acetyltransferase. Advances in Biochemical Psychopharmacology 3: 241-263.
Klein, D.C., Berg, G.R., Weller, J.L. and Glinsmann, W. (1970) Pineal gland: Dibutyryl cyclic adenosine monophosphate stimulation of labelled melatonin production. Science 167: 1738-1740. PDF
Klein, D.C., Berg, G.R. and Weller, J.L. (1970) Melatonin synthesis: Adenosine 3',5'-monophosphate and norepinephrine stimulate N-acetyltransferase. Science 168: 979-980. PDF
Klein, D.C. and Raisz, L.G. (1970) Prostaglandins: Stimulation of bone resorption in tissue culture. Endocrinology 86: 1436-1440. PDF
Klein, D.C. and Rowe, J. (1970) Pineal gland in organ culture. I. Inhibition by harmine of serotonin-14C oxidation, accompanied by stimulation of melatonin-14C production. Molecular Pharmacology 6: 164-171.
Klein, D.C. and Weller, J.L. (1970) Input and output signals in a model neural system: The regulation of melatonin production in the pineal gland. In Vitro 6:197-240.
Klein, D.C. and Weller, J.L. (1970) Indole metabolism in the pineal gland: A circadian rhythm in N-acetyltransferase. Science 169: 1093-1095. PDF
Raisz, L.G., Klein, D.C. Trummel, C.T. and Brand, J.S. (1970) Hormonal factors influencing bone resorption in tissue culture. In: Hormone Regulation, Hamburgh, M. and Barrington, E.J.W. (Eds.). Appleton Century-Crofts, New York, pp. 679-686.
Rowe, J.W., Reichert, J.R., Klein, D.C. and Reichlin, S. (1970) Relation of the pineal gland and environmental lighting to thyroid function in the rat. Neuroendocrinology 6: 247-254.
Klein, D.C. and Lines, S.V. (1969) Pineal hydroxyindole-O-methyltransferase activity in the growing rat. Endocrinology 84: 1523-1525.
Klein, D.C. and Notides, A. (1969) Thin-layer chromatographic separation of pineal gland derivatives of serotonin-14C. Analytical Biochemistry 31: 480-483. PDF
Reiter, R.J., Klein, D.C. and Donofrio, R.J. (1969) Preliminary observations on the reproductive effects of the pineal gland in blinded, anosmic male rats. Journal of Reproduction and Fertility 19: 563-565.
Klein, D.C. and Talmage, R.V. (1968) Thyrocalcitonin suppression of hydroxyproline release from bone. Proceedings of the Society for Experimental Biology and Medicine 127: 95-99.
Klein, D.C. and Talmage, R.V. (1968) Evidence of the secretion of thyrocalcitonin at normal and subnormal plasma calcium levels. Endocrinology 82: 132-136.
Raisz, L.G., Brand, J.S., Klein, D.C. and Au, W.Y.W. (1968) Hormonal factors influencing bone resorption. In: Progress in Endocrinology, Excerpta Medica International Congress Series No. 184, 696-703.
Klein, D.C., Morii, H., and Talmage, R.V. (1967) Effect of thyrocalcitonin, administered during peritoneal lavage, on removal of bone salts and their radioisotopes. Proceedings of the 50th Annual Meeting of the Federation of American Societies for Experimental Biology (30) 124: 627-633.
Talmage, R.V. and Klein, D.C. (1967) Relation of endogenous thyrocalcitonin secretion to plasma calcium levels. Calcitonin: Proceedings of the Symposium on Thyrocalcitonin and the C Cells. pp. 260-267, William Heinemann Medical Books Ltd., London.
Klein, D.C. (1967) The mode of action of thyrocalcitonin. Thesis, Rice University.