Smith KJ, Nelson A, Wagner KF, Hackley B; Conference on Retroviruses and Opportunistic Infections.
Program Abstr 3rd Conf Retrovir Oppor Infect Conf Retrovir Oppor Infect 3rd 1996 Wash D C. 1996 Jan 28-Feb 1; 3rd: 112.
USAMRICO, Aberdeen, MD.
Delayed hypersensitivity reactions (DTH) are lost with progression of HIV disease. This loss of DTH commonly occurs before the onset of opportunistic infections, and has been shown to be an independent predictor of disease progression. Ten HIV+ patients with a past history of allergic contact dermatitis (ACD) to poison ivy were tested with the extract prepared from poison ivy. All but one patient had a CD4+ T cell counts less than 200/ml, and four patients had a history of an opportunistic infection . All ten patients showed position reactions ranging from mild erythema and infiltration to marked erythema with bullae formation. The cytokine pattern in ACD is a T helper-1 pattern. ACD is considered a variant of DTH. However, the effected cells in ACD may be more diverse than in DTH. This diversity, as well as the variable effect of HIV disease on Langerhans cell function, may explain the continued reaction to some contact allergens in late disease, and may be important allergens for immunotherapy in the use of contact allergens for immunotherapy.
Publication Types:
Keywords:
- Acquired Immunodeficiency Syndrome
- Allergens
- Anti-Allergic Agents
- Antigens, CD4
- CD4-Positive T-Lymphocytes
- Catechols
- Dermatitis, Allergic Contact
- Dermatitis, Toxicodendron
- Disease Progression
- Erythema
- HIV Infections
- HIV Seropositivity
- Humans
- Hypersensitivity, Delayed
- Immunotherapy
- T-Lymphocytes
- Toxicodendron
- immunology
- urushiol
Other ID:
UI: 102216369
From Meeting Abstracts