Use of peripheral dopamine antagonist (Motilium) in the treatment of dyspeptic complaints of different origin and in nausea, vomiting.

The incidence of dyspepsias and emesis occurring either as accompanying symptoms of gynaecological operations or as independent clinical conditions, therapeutic means for controlling these conditions and the mechanism of action and clinical usefulness of the dopamine antagonist domperidone have been discussed. The observations with this drug in 68 women suffering from dyspepsia and in 94 cases of emesis of different etiology have been analysed. The author stated that Motilium is the drug of choice in the treatment of complaints due to motility disorder of the upper gastroduodenal tract, that the patients tolerate the drug well, and that it's use does not hinder the treatment of the primary gynaecological disease, pre-operative therapy, anaesthesia, and postoperative care of the patients. Its antiemetic effect depends on the time of intake which is a disadvantage of oral application.

PMID: 2588201 [PubMed - indexed for MEDLINE]