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Title Epoxidation of prostacyclin in the rabbit kidney
Creator/Author Wong, P.Y. ; Malik, K.U. ; Taylor, B.M. ; Schneider, W.P. ; McGiff, J.C. ; Sun, F.F.
Publication Date1985 Aug 05
OSTI IdentifierOSTI ID: 6085905
Other Number(s)CODEN: JBCHA
Resource TypeJournal Article
Resource RelationJ. Biol. Chem. ; Vol/Issue: 16
Research OrgNew York Medical College, Valhalla
Subject550201 -- Biochemistry-- Tracer Techniques; PROSTAGLANDINS-- OXIDATION;PROSTAGLANDINS-- RADIOCHROMATOGRAPHY;TRITIUM COMPOUNDS-- RADIOCHROMATOGRAPHY; GAS CHROMATOGRAPHY;KIDNEYS;MASS SPECTRA;METABOLITES;RABBITS
Related SubjectANIMALS;BODY;CHEMICAL REACTIONS;CHROMATOGRAPHY;LABELLED COMPOUNDS;MAMMALS;ORGANS;SEPARATION PROCESSES;SPECTRA;VERTEBRATES
Description/Abstract In the isolated Tyrode`s perfused rabbit kidney, metabolism of (9-TH)prostacyclin was examined.^In addition to 7,9-dihydroxy-4,13-diketo-dinor-prostanoic acid, dinor-6-keto-prostaglandin F1 alpha, and pentanorprostaglandin (PG)F1 alpha gamma-lactone, a new, previously unreported, metabolite was isolated and identified by radio-gas chromatography and gas chromatography-mass spectrometry as 5-hydroxy-6-keto-PGF1 alpha.^The structure of this metabolite was further confirmed by comparison of the mass spectra to that of the synthetic standard.^The formation of 5-hydroxy-6-keto-PGF1 alpha in the kidney suggested epoxidation of prostacyclin via the renal epoxygenase pathway.
Country of PublicationUnited States
LanguageEnglish
FormatPages: 9150-9153
System Entry Date2001 May 13

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