Bibliographic Citation
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Title | Epoxidation of prostacyclin in the rabbit kidney |
Creator/Author | Wong, P.Y. ; Malik, K.U. ; Taylor, B.M. ; Schneider, W.P. ; McGiff, J.C. ; Sun, F.F. |
Publication Date | 1985 Aug 05 |
OSTI Identifier | OSTI ID: 6085905 |
Other Number(s) | CODEN: JBCHA |
Resource Type | Journal Article |
Resource Relation | J. Biol. Chem. ; Vol/Issue: 16 |
Research Org | New York Medical College, Valhalla |
Subject | 550201 -- Biochemistry-- Tracer Techniques; PROSTAGLANDINS-- OXIDATION;PROSTAGLANDINS-- RADIOCHROMATOGRAPHY;TRITIUM COMPOUNDS-- RADIOCHROMATOGRAPHY; GAS CHROMATOGRAPHY;KIDNEYS;MASS SPECTRA;METABOLITES;RABBITS |
Related Subject | ANIMALS;BODY;CHEMICAL REACTIONS;CHROMATOGRAPHY;LABELLED COMPOUNDS;MAMMALS;ORGANS;SEPARATION PROCESSES;SPECTRA;VERTEBRATES |
Description/Abstract | In the isolated Tyrode`s perfused rabbit kidney, metabolism of (9-TH)prostacyclin was examined.^In addition to 7,9-dihydroxy-4,13-diketo-dinor-prostanoic acid, dinor-6-keto-prostaglandin F1 alpha, and pentanorprostaglandin (PG)F1 alpha gamma-lactone, a new, previously unreported, metabolite was isolated and identified by radio-gas chromatography and gas chromatography-mass spectrometry as 5-hydroxy-6-keto-PGF1 alpha.^The structure of this metabolite was further confirmed by comparison of the mass spectra to that of the synthetic standard.^The formation of 5-hydroxy-6-keto-PGF1 alpha in the kidney suggested epoxidation of prostacyclin via the renal epoxygenase pathway. |
Country of Publication | United States |
Language | English |
Format | Pages: 9150-9153 |
System Entry Date | 2001 May 13 |
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