|
EC-NUMBER
|
1.1.1.274
|
|
ENZYME-NAME
|
2,5-didehydrogluconate reductase
|
|
ENZYME-SYSNAME
|
This is a key enzyme in the microbial production of ascorbate. Can also reduce ethyl 2-methylacetoacetate stereoselectively to ethyl (2R)-methyl-(3S)-hydroxybutanoate and can also accept some other beta-keto esters. The identification of a bacterial beta-keto ester reductase as a 2,5-didehydrogluconate reductase links two previously separate areas of biocatalysis, i.e., asymmetric carbonyl reduction and microbial vitamin C production.
|
|
ENZYME-CLASS
|
Oxidoreductases Acting on the CH-OH group of donors With NAD+ or NADP+ as acceptor
|
|
SYNONYMS
|
2,5-didehydrogluconate reductase;;
2,5-diketo-D-gluconate reductase;;
YqhE reductase;
>>more synonyms
|
|
REACTION
|
2-dehydro-D-gluconate + NADP+ = 2,5-didehydro-D-gluconate + NADPH + H+ [RN:R05823]
|
|
PATHWAY
|
EMP-PATHWAYS:
NO EMP PATHWAY FOUND
|
|
|
KEGG-PATHWAYS:
NO KEGG PATHWAY FOUND
|
|
GO_TERM
|
GO:0050580:2,5-didehydrogluconate reductase activity
|
|
ENZYME-COMMENT
|
2-dehydro-D-gluconate:NADP+ 2-oxidoreductase
|
|
