| PROPOSAL NUMBER: | 04 B3.03-9533 |
| SUBTOPIC TITLE: | Human Adaptation and Countermeasures |
| PROPOSAL TITLE: | Non-Invasive Transcranial Doppler Sonogram Device for Detection of Embolic Air in Cerebral Arteries |
SMALL BUSINESS CONCERN
(Name, E-mail, Mail Address, City/State/Zip, Phone)
GENEXPRESS INFORMATICS INC.
13091 Ponds Springs Road, Suite 150
Austin, TX 78729-6442
(512)219-8588
PRINCIPAL INVESTIGATOR/PROJECT MANAGER
(Name, E-mail, Mail Address, City/State/Zip, Phone)
Robert Chin
rchin@genexpressinfo.com
13091 Ponds Springs Road, Suite 150
Austin, TX 78729-6442
(512)219-8588
TECHNICAL ABSTRACT (LIMIT 200 WORDS)
Technology is needed to provide real-time assessment and evaluation of hematological parameters during prolong space flights and planetary missions. A key hematological parameter is the monitoring and measurement of emboli in the brain especially during Extra-Vehicular Activity (EVA) on planetary surfaces as well as orbital flights. A non-invasive, compact Transcranial Doppler (TCD) measurement device will provide monitoring of flight crew blood physiology during extended duration missions and deliver this data to onboard flight surgeons.
To address this need, GeneXpress Informatics (GXI) and Leonid Bunegin and Dr. Claudia S. Miller of the University of Texas Health Science Center (UTHSC) at San Antonio proposes to develop a non-invasive, portable TCD sonogram based diagnostic system for real-time monitoring and detection of cerebral artery air embolisms. The detection system uses intensity audio signals and Fast Fourier Transform (FFT) analysis to detect and locate the TCD audio signals of air bubbles in the middle cerebral artery (MCA).
In Phase I, GXI proposes to develop and demonstrate the non-invasive use TCD measurements for the determination of air emboli. In Phase II, GXI will proceed to a prototype development which will include construction and fabrication of a handheld field portable frequency-domain TCD measurement system.
POTENTIAL NASA COMMERCIAL APPLICATIONS (LIMIT 100 WORDS)
Technology is needed to provide real-time assessment and evaluation of hematological parameters during prolong space flights and planetary missions. A key hematological parameter is the monitoring and measurement of emboli in the brain especially during Extra-Vehicular Activity (EVA) on planetary surfaces as well as orbital flights.
POTENTIAL NON-NASA COMMERCIAL APPLICATIONS (LIMIT 100 WORDS)
Total mortality rates in severe trauma occurrences show that 90 percent die within the first hour. Whether in war time situations or automotive accidents, there is a need for technologies which can provide more expertise in the forward area at the site of the incident. This non-invasive TCD technology developed in this program will provide an aid to paramedics in evaluating a trauma patient on site and in real-time.