Chuck SK, Areff D; International Conference on AIDS.
Int Conf AIDS. 2002 Jul 7-12; 14: abstract no. WePeB5855.
Grady Health System, Atlanta, GA, United States
BACKGROUND: Anecdotally Videx tablets are poorly tolerated resulting in decreased quality of life & sub-optimal adherence. Advantages of VidexEC are less frequent dosing & fewer pills (1 vs 4/day). The objective was to document differences in tolerability & adherence after switching from Videx to VidexEC. METHODS: Pts on VidexEC for >4 wks with prior Videx use were surveyed to examine switching reasons, frequency preference & adherence. Overall satisfaction and the frequency, severity, & bothersomeness of adverse effects were evaluated. RESULTS: Surveyed 50 pts: 41 male; 40+/-7yo; 68% AA; 62% MSM; CD4 361+/-287; VL log 2.8+/-1.1; 6+/-3yr of therapy. Videx & VidexEC durations were 21+/-16mos & 8+/-3mos. Important reasons for switch: fewer pills, ease of taking, more effective, less overall side effects & doctor recommendation. Pts satisfied with: dosing regimen, ease of taking, & effects on daily activities, CD4 & VL. 46% noted increased energy. Adherence: 80% felt decreasing to daily for 1 drug is very helpful. Monthly or more frequent missed doses noted while on Videx & VidexEC in 46% & 8%. 82% noted no missed VidexEC doses in last month & 66% for last 3 mos. Tolerability: 74% noted disagreeable taste of Videx. GI effects occurred less frequently on VidexEC; weekly-daily nausea/vomiting (N/V) (38% vs 8%), bloating/gas pain(32% vs 12%), appetite loss(30% vs 2%), & diarrhea(48% vs 22%). Noted improvements in frequency of bloating/gas pain/appetite loss & N/V/diarrhea in 38-46% & 50-58%. 30-35% had less severe N/V/diarrhea. Diarrhea & N/V bothersomeness decreased in 55% & 80%. Neuropathy prevalence decreased (52% to 38%) with similar daily frequency (20% vs 16%). Decreases in frequency, severity, & bothersomeness of neuropathy noted in 32%, 24%, & 35%. CONCLUSION: Together, an easier dosing regimen & better tolerability with less frequent, less severe, & less bothersome adverse effects are likely explanations for improved adherence with VidexEC.
Publication Types:
Keywords:
- Antigens, CD4
- Capsules
- Diarrhea
- Didanosine
- Male
- Nausea
- immunology
Other ID:
UI: 102254396
From Meeting Abstracts