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Title Mutational analyses of fs(1)Ya, an essential, developmentally regulated, nuclear envelope protein in Drosophila
Creator/Author Liu, Jun ; Song, Kiwon ; Wolfner, M.F. [Cornell Univ., Ithaca, NY (United States)]
Publication Date1995 Dec 01
OSTI IdentifierOSTI ID: 535348
Other Number(s)GENTAE; ISSN 0016-6731
Resource TypeJournal Article
Resource RelationGenetics ; VOL. 141 ; ISSUE: 4 ; PBD: Dec 1995
Subject55 BIOLOGY AND MEDICINE, BASIC STUDIES ; DROSOPHILA; ONTOGENESIS; EMBRYOS; MUTANTS; PHENOTYPE; ANIMAL CELLS; CELL CYCLE; PROTEINS; MUTATIONS; STRUCTURE-ACTIVITY RELATIONSHIPS; MITOSIS; CHROMATIN; MEIOSIS; CELL NUCLEI
Description/Abstract The fs(1)Ya protein (YA) is an essential, maternally encoded, nuclear lamina protein that is under both developmental and cell cycle control. A strong Ya mutation results in early arrest of embryos. To define the function of YA in the nuclear envelope during early embryonic development, we characterized the phenotypes of four Ya mutant alleles and determined their molecular lesions. Ya mutant embryos arrest with abnormal nuclear envelopes prior to the first mitotic division; a proportion of embryos from two leaky Ya mutants proceed beyond this but arrest after several abnormal divisions. Ya unfertilized eggs contain nuclei of different sizes and condensation states, apparently due to abnormal fusion of the meiotic products immediately after meiosis. Lamin is localized at the periphery of the uncondensed nuclei in these eggs. These results suggest that Ya function is required during and after egg maturation to facilitate proper chromatin condensation, rather than to allow a lamin-containing nuclear envelope to form. Two leaky Ya alleles that partially complement have lesions at opposite ends of the YA protein, suggesting that the N- and C-termini are important for YA function might interact with itself either directly or indirectly. 27 refs., 6 figs.
Country of PublicationUnited States
LanguageEnglish
Formatpp. 1473-1481 ; PL:
System Entry Date2001 May 05

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