| US 7,393,522 B2 | ||
| Physiologically balanced, ionized, acidic solution and methodology for use in wound healing | ||
| Ramin Najafi, Novato, Calif. (US); Lu Wang, Emeryville, Calif. (US); Mansour Bassiri, Davis, Calif. (US); and Jane Yang, Emeryville, Calif. (US) | ||
| Assigned to NovaBay Pharmaceuticals, Inc., Emeryville, Calif. (US) | ||
| Filed on Sep. 03, 2003, as Appl. No. 10/655,493. | ||
| Application 10/000919 is a division of application No. 09/482159, filed on Jan. 12, 2000, granted, now 6,426,066. | ||
| Application 10/655493 is a continuation in part of application No. 10/209681, filed on Jul. 30, 2002. | ||
| Application 10/209681 is a continuation in part of application No. 10/000919, filed on Nov. 02, 2001, abandoned. | ||
| Prior Publication US 2004/0137078 A1, Jul. 15, 2004 | ||
| This patent is subject to a terminal disclaimer. | ||
| Int. Cl. A61K 31/74 (2006.01); A61K 33/40 (2006.01); A61K 33/14 (2006.01) | ||
| U.S. Cl. 424—78.04 [424/78.06; 424/78.07; 424/613; 424/661] | 7 Claims |
| 1. A method for the treatment of a medical condition selected from the groups consisting of disinfection or decontamination of open wounds and burns, promotion of wound healing, and ocular disinfection or decontamination in a patient in need of such treatment comprising: applying to a treatment site with an effective amount of a stable aqueous physiologically balanced, ionized solution comprising an acidic solution of hypohalous acid with a concentration from about 10 ppm to about 200 ppm; a halide comprising salt, from about 0.4 g/L to about 20.4 g/L, said solution having a pH range from about 3.0 to about 4.0, an original oxidation reduction potential (ORP) at room temperature ranging from about +600 mV to about +1200 mV, and said ORP ranging from no less than about 90 to 97.5% of the original ORP after three months at room temperature; and said solution when stored in a chemically non-reactive container at room temperature over at least three months, the solution is characterized as having a reduced hypohalous acid concentration of between 1-95% as determined by UV-VIS or by iodometric titration. |