Decazes JM, Welker Y, Casin I, Doco-Lecompete T, Modai J; International Conference on AIDS.
Int Conf AIDS. 1992 Jul 19-24; 8: B114 (abstract no. PoB 3163).
Saint-Louis Hospital, Paris, France.
OBJECTIVES. To determine the clinical aspects and treatment antibiotics of Salmonella infections in HIV-1 seropositive patients. METHODS. A retrospective study of all cases of salmonella infections in a infectious disease section in PARIS (1988-1991). RESULTS. Twelve septicaemias, 1 osteitis, 2 intestinal infections caused by S. typhimurium (n = 7). S. enteritidis (n = 8) were observed in 13 men and 2 women with HIV infection. The median age was 36 years (29-49), and risk factors for HIV infection were homosexuality (n = 10), IV drug abuse (n = 2), blood transfusion (n = 1), heterosexual activity with HIV-partner (n = 2). Salmonellosis was the first opportunistic infection in 6 patients. Four patients presented with focal Salmonella infection (endocarditis, psoas abscess, rib abscess prostatitis). The mean CD4 cells count was constantly less than 250/microliters (114 +/- 78). All strain were susceptible to fluoroquinolones (FQs). Resistances were noted to aminopenicillin (n = 3) TMP/SMX (n = 1). Chloramphenicol (n = 3). Antibiotics used were FQs (n = 12). TMP/SMX (n = 1) aminopenicillin (n = 1) and a third generation cephalosporin (TGC, n = 1). Cure was obtained in 12 patients. Two patients rapidly died of lymphoma. One patient who failed under TGC was effectively treated with FQ. Mean treatment duration was 31 days (15-60). Septic foci caused early relapses in 2 patients (prostatitis, psoas abscess). AZT was initiated after antibiotic therapy. No relapse occurred in 13 survivals patients who received AZT (mean follow up time 12 months) although 7 of them received no antibiotics during the follow up period. CONCLUSIONS. We conclude that salmonellosis in HIV infected patients may present with various unusual locations and may be effectively treated with FQ. The potential role of AZT therapy in preventing relapses of Salmonella infection deserves further studies.
Publication Types:
Keywords:
- AIDS Vaccines
- Acquired Immunodeficiency Syndrome
- Anti-Bacterial Agents
- Female
- HIV Infections
- HIV Seropositivity
- HIV-1
- Humans
- Male
- Paris
- Retrospective Studies
- Salmonella
- Salmonella Food Poisoning
- Salmonella Infections
- Zidovudine
- psychology
- therapy
Other ID:
UI: 102198613
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