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Title Further characterization of immunological unresponsiveness induced in mice by ultraviolet radiation
Creator/Author Kripke, M.L. ; Thorn, R.M. ; Lill, P.H. ; Civin, C.I. ; Pazmino, N.H. ; Fisher, M.S.
Publication Date1979 Sep 01
OSTI IdentifierOSTI ID: 5332380
Other Number(s)CODEN: TRPLA
Resource TypeJournal Article
Resource RelationTransplantation ; Vol/Issue: 28:3
Research OrgNational Cancer Inst., Frederick, MD
Subject560152 -- Radiation Effects on Animals-- Animals ;550200 -- Biochemistry ;551000 -- Physiological Systems; ;ANTIGEN-ANTIBODY REACTIONS-- BIOLOGICAL RADIATION EFFECTS;MICE-- IMMUNITY;NEOPLASMS-- ANTIGEN-ANTIBODY REACTIONS; GRAFT-HOST REACTION;IMMUNE REACTIONS;LEUKEMIA;MAMMARY GLANDS;PICRIC ACID;RADIOINDUCTION;SARCOMAS;SPLEEN;TRANSPLANTS;TUMOR CELLS;ULTRAVIOLET RADIATION
Related SubjectANIMAL CELLS;ANIMALS;AROMATICS;BIOLOGICAL EFFECTS;BODY;CHEMICAL EXPLOSIVES;DISEASES;ELECTROMAGNETIC RADIATION;EXPLOSIVES;GLANDS;HEMIC DISEASES;HYDROXY COMPOUNDS;MAMMALS;NEOPLASMS;NITRO COMPOUNDS;ORGANIC COMPOUNDS;ORGANIC NITROGEN COMPOUNDS;ORGANS;PHENOLS;RADIATION EFFECTS;RADIATIONS;RODENTS;VERTEBRATES
Description/Abstract Ultraviolet (uv)-irradiated mice were compared with unirradiated mice for their susceptibility to primary and transplanted tumors etiologically unrelated to uv radiation.^Although uv-irradiated mice are unable to reject transplants of highly antigenic syngeneic tumors induced by uv light, the growth of syngeneic, non-uv-induced tumors generally was not accelerated in these animals.^Furthermore, uv-irradiated mice were no more susceptible to the induction of primary leukemias, mammary tumors, or sarcomas than were unirradiated animals.^Tests of immune responses to weak transplantation antigens showed that uv-irradiated mice rejected H-Y-incompatible skin grafts as vigorously as did normal animals, and that the primary in vitro cytotoxic responses of spleen cells from uv-irradiated mice to trinitrophenyl (TNP)-modified syngeneic cells and to Hh antigens were unaffected.^We conclude that the susceptibility of uv-irradiated mice to challenge with uv-induced tumors represents a selective unresponsiveness, and that it is not attributable to a generalized deficiency in the immune response to tumor-specific antigens or to weak transplantation antigens.
Country of PublicationUnited States
LanguageEnglish
FormatPages: 212-217
System Entry Date2001 May 13

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