Disclaimer: The information contained in these
guidelines is intended for reference purposes only. It provides a
summary of information about chemicals that workers may be
exposed to in their workplaces. The information contained in
these guidelines is current as of date of publication (September,
1996); recommendations may be superseded by new developments in
the field of industrial hygiene. Readers are therefore advised to
regard these recomendations as general guidelines and to
determine whether new information is available.
OCCUPATIONAL SAFETY AND HEALTH GUIDELINE FOR tert-BUTYL ALCOHOL
INTRODUCTION
This guideline summarizes pertinent information about tert-butyl alcohol
for workers and employers as well as for physicians, industrial hygienists,
and other occupational safety and health professionals who may need such
information to conduct effective occupational safety and health programs.
Recommendations may be superseded by new developments; readers are
therefore advised to regard these recommendations as general guidelines and
to determine periodically whether new information is available.
SUBSTANCE IDENTIFICATION
* Formula
C(4)H(10)O
* Structure
(For Structure, see paper copy)
* Synonyms
tert-Butanol; 2-methyl-2-propanol; TBA; t-butyl hydroxide;
1,1-dimethylethanol; trimethylmethanol; trimethylcarbinol.
* Identifiers
1. CAS 75-65-0.
2. RTECS EO1925000.
3. DOT UN: 1120 26.
4. DOT label: Flammable Liquid.
* Appearance and odor
At room temperature, tert-butyl alcohol is a colorless, crystalline
solid that has a camphor-like odor; this substance melts to form a
volatile liquid at 25.6 degrees C (78.1 degrees F).
CHEMICAL AND PHYSICAL PROPERTIES
* Physical data
1. Molecular weight: 74.1.
2. Boiling point (760 torr): 82.4 degrees C (180 degrees F).
3. Specific gravity (water = 1): 0.79 at 20 degrees C (68 degrees F).
4. Vapor density (air = 1 at boiling point of tert-butyl alcohol): 2.55.
5. Melting point: 25.6 degrees C (78.1 degrees F).
6. Vapor pressure at 20 degrees C (68 degrees F): 13 torr.
7. Solubility: Soluble in water; miscible with alcohol and ether.
8. Evaporation rate (butyl acetate = 1): 1.05.
* Reactivity
1. Conditions contributing to instability: Heat, sparks, and open flame.
2. Incompatibilities: Contact of tert-butyl alcohol with oxidizing
agents, strong mineral acids, or strong hydrochloric acid causes fires
and explosions.
3. Hazardous decomposition products: Toxic gases (such as carbon
monoxide or isobutylene) may be released when tert-butyl alcohol
decomposes in contact with strong mineral acids.
4. Special precautions: None.
* Flammability
The National Fire Protection Association has assigned a flammability
rating of 3 (dangerous fire hazard) to tert-butyl alcohol.
1. Flash point: 11 degrees C (52 degrees F).
2. Autoignition temperature: 478 degrees C (892 degrees F).
3. Flammable limits in air (percent by volume): Lower, 2.4; upper, 8.0.
4. Extinguishant: Use dry chemical, carbon dioxide, alcohol foam, or
water fog to fight fires involving tert-butyl alcohol. Blanket the
fire to smother it. Water may be ineffective in extinguishing the
fire, but a water spray may be used to cool fire-exposed containers.
If a leak or spill has not ignited, water spray may be used to
disperse vapors and to dilute spills to a nonflammable mixture.
Fires involving tert-butyl alcohol should be fought upwind and from
the maximum distance possible. Keep unnecessary people away; isolate
hazard area and deny entry. Emergency personnel should stay out of
low areas and ventilate closed spaces before entering. Vapors may
travel to a source of ignition and then flash back. Vapor explosions
may occur indoors, outdoors, or in sewers. Containers of tert-butyl
alcohol may explode in the heat of the fire and should be moved from
the fire area if it is possible to do so safely. If this is not
possible, cool containers from the sides with water until well after
the fire is out. Stay away from the ends of containers. Personnel
should withdraw immediately if a rising sound from a venting safety
device is heard or if there is discoloration of a container due to
fire. Dikes should be used to contain fire-control water for later
disposal. If a tank car or truck is involved in a fire, personnel
should isolate an area of a half a mile in all directions.
Firefighters should wear a full set of protective clothing, including
a self-contained breathing apparatus, when fighting fires involving
tert-butyl alcohol. Firefighters' protective clothing may provide
limited protection against fires involving tert-butyl alcohol.
* Warning properties
The average air odor detection threshold for tert-butyl alcohol is 960
parts per million (ppm) parts of air. Because this value is above the
Occupational Safety and Health Administration (OSHA) current
permissible exposure limit (PEL) of 100 ppm [29 CFR 1910.1000, Table
Z-1-A], tert-butyl alcohol is considered to have inadequate warning
properties for the purpose of respirator selection.
* Eye irritation properties
No information is available on the specific concentration of
tert-butyl alcohol that causes eye irritation in humans; however, this
substance is known to cause eye irritation at high but unspecified
concentrations.
EXPOSURE LIMITS
The current OSHA PEL for tert-butyl alcohol is 100 ppm (300 milligrams per
cubic meter (mg/m3)) as an 8-hour time-weighted average (TWA)
concentration and 150 ppm (450 mg/m3) as a 15-minute short-term exposure
limit (STEL). A STEL is the maximum 15-minute concentration to which
workers may be exposed during any 15-minute period of the working day [29
CFR 1910.1000, Table Z-1-A]. The National Institute for Occupational
Safety and Health (NIOSH) has not issued a recommended exposure limit (REL)
for tert-butyl alcohol; however, NIOSH concurs with the PEL established for
this substance by OSHA [NIOSH 1988]. The American Conference of
Governmental Industrial Hygienists (ACGIH) has assigned tert-butyl alcohol
a threshold limit value (TLV) of 100 ppm (303 mg/m3) as a TWA for a
normal 8-hour workday and a 40-hour workweek and a short-term exposure
limit (STEL) of 150 ppm (455 mg/m3) for periods not to exceed 15 minutes
[ACGIH 1989, p. 14]. The OSHA and ACGIH limits are based on the risk of
narcotic effects associated with exposure to tert-butyl alcohol.
HEALTH HAZARD INFORMATION
* Routes of exposure
Exposure to tert-butyl alcohol can occur via inhalation, ingestion,
and eye or skin contact.
* Summary of toxicology
1. Effects on Animals: tert-Butyl alcohol causes narcosis in animals
exposed to high concentrations. The oral LD(50) in rats is 3500 mg/kg
[RTECS 1990]. Acutely poisoned animals showed behavioral effects,
ataxia, and other narcotic signs before death [RTECS 1990; Proctor,
Hughes, and Fischman 1988, p. 108]. tert-Butyl alcohol is reported to
have a stronger narcotic effect on mice than other butyl alcohols
[ACGIH 1986, p. 78]. Rats given nontoxic doses of tert-butyl alcohol
(0.0163 mol/kg) showed a marked decline in performance test scores;
tert-butyl alcohol caused a narcotic effect estimated to be 4.8 times
greater than that of ethanol [Clayton and Clayton 1982, p. 4587].
Prolonged contact of tert-butyl alcohol with the skin of rabbits
caused no irritation [Clayton and Clayton 1982, p. 4587]. Long-term
exposure to low (not further specified) concentrations of tert-butyl
alcohol caused no observable effects in experimental animals [ACGIH
1986, p. 78].
2. Effects on Humans: tert-Butyl alcohol causes eye, skin, and mucous
membrane irritation in humans; at high concentrations, it causes
narcosis. In contact with the skin of humans, tert-butyl alcohol
caused slight redness and hyperemia; prolonged skin contact may cause
contact dermatitis [Clayton and Clayton 1982, p. 4587; HSDB 1985].
Exposure to "excessive" (not further specified) concentrations is
reported to have caused eye, nose, and throat irritation, headache,
nausea, fatigue, and dizziness in humans [Clayton and Clayton 1982,
p. 4587].
* Signs and symptoms of exposure
1. Acute exposure: The signs and symptoms of acute exposure to
tert-butyl alcohol include irritation and redness of the eyes, runny
nose, and scratchy throat; headache; nausea; fatigue; dizziness; and
redness and drying of the skin.
2. Chronic exposure: The signs and symptoms of chronic exposure to
tert-butyl alcohol include defatting of the skin and dermatitis.
* Emergency procedures:
In the event of an emergency, remove the victim from further exposure,
send for medical assistance, and initiate the following emergency
procedures:
1. Eye exposure: If tert-butyl alcohol or a solution containing this
substance gets into the eyes, immediately flush the eyes with large
amounts of water for a minimum of 15 minutes, lifting the lower and
upper lids occasionally. If irritation persists, get medical
attention as soon as possible.
2. Skin exposure: If tert-butyl alcohol or a solution containing this
substance contacts the skin, the contaminated skin should be washed
with soap and water. If irritation persists, get medical attention.
3. Inhalation: If the vapors of tert-butyl alcohol are inhaled, move the
victim at once to fresh air and get medical care as soon as possible.
If the victim is not breathing, perform cardiopulmonary resuscitation;
if breathing is difficult, give oxygen. Keep the victim warm and
quiet until medical help arrives.
4. Ingestion: If tert-butyl alcohol or a solution containing this
substance is ingested, give the victim several glasses of water to
drink and then induce vomiting by having the victim touch the back of
the throat with the finger or by giving syrup of ipecac as directed on
the package. Do not force an unconscious or convulsing person to
drink liquids or to vomit. Get medical help immediately. Keep the
victim warm and quiet until medical help arrives.
5. Rescue: Remove an incapacitated worker from further exposure and
implement appropriate emergency procedures (e.g., those listed on the
Material Safety Data Sheet required by OSHA's Hazard Communication
Standard, 29 CFR 1910.1200). All workers should be familiar with
emergency procedures and the location and proper use of emergency
equipment.
EXPOSURE SOURCES AND CONTROL METHODS
The following operations may involve tert-butyl alcohol and lead to worker
exposures to this substance:
* Use as a solvent for paints, lacquers, varnishes, natural and
synthetic resins, gums, vegetable oils, dyes, camphor, and alkaloids,
and as an octane booster in unleaded gasoline
* Manufacture of artificial leather, safety glass, rubber and plastic
cements, shellac, raincoats, photographic films, flotation agents,
fruit essences, perfumes, cellulose esters, lacquers, paint removers,
and plastics
* Use as a denaturant for alcohol and as a chemical intermediate in the
manufacture of methyl methacrylate and pharmaceuticals
Methods that are effective in controlling worker exposures to tert-butyl
alcohol, depending on the feasibility of implementation, are
* Process enclosure,
* Local exhaust ventilation,
* General dilution ventilation, and
* Personal protective equipment.
The following publications are good sources of information on control
methods:
1. ACGIH [1986]. Industrial ventilation--a manual of recommended
practice. Cincinnati, OH: American Conference of Governmental
Industrial Hygienists.
2. Burton DJ [1986]. Industrial ventilation--a self study companion.
Cincinnati, OH: American Conference of Governmental Industrial
Hygienists.
3. Alden JL, Kane JM [1982]. Design of industrial ventilation systems.
New York, NY: Industrial Press, Inc.
4. Wadden RA, Scheff PA [1987]. Engineering design for control of
workplace hazards. New York, NY: McGraw-Hill.
5. Plog BA [1988]. Fundamentals of industrial hygiene. Chicago, IL:
National Safety Council.
MEDICAL MONITORING
Workers who may be exposed to chemical hazards should be monitored in
a systematic program of medical surveillance that is intended to
prevent occupational injury and disease. The program should include
education of employers and workers about work-related hazards,
placement of workers in jobs that do not jeopardize their safety or
health, early detection of adverse health effects, and referral of
workers for diagnosis and treatment. The occurrence of disease or
other work-related adverse health effects should prompt immediate
evaluation of primary preventive measures (e.g., industrial hygiene
monitoring, engineering controls, and personal protective equipment).
A medical monitoring program is intended to supplement, not replace,
such measures. To place workers effectively and to detect and control
work-related health effects, medical evaluations should be performed
(1) before job placement, (2) periodically during the period of
employment, and (3) at the time of job transfer or termination.
* Preplacement medical evaluation
Before a worker is placed in a job with a potential for exposure to
tert-butyl alcohol, the examining physician should evaluate and
document the worker's baseline health status with thorough medical,
environmental, and occupational histories, a physical examination, and
physiologic and laboratory tests appropriate for the anticipated
occupational risks. These should concentrate on the function and
integrity of the eyes, skin, and respiratory tract. Medical
monitoring for respiratory disease should be conducted using the
principles and methods recommended by NIOSH and the American Thoracic
Society.
A preplacement medical evaluation is recommended to assess an
individual's suitability for employment at a specific job and to
detect and assess medical conditions that may be aggravated or may
result in increased risk when a worker is exposed to tert-butyl
alcohol at or below the prescribed exposure limit. The examining
physician should consider the probable frequency, intensity, and
duration of exposure as well as the nature and degree of any
applicable medical condition. Such conditions (which should not be
regarded as absolute contraindications to job placement) include a
history and other findings consistent with diseases of the eyes, skin,
or respiratory tract.
* Periodic medical examinations and biological monitoring
Occupational health interviews and physical examinations should be
performed at regular intervals during the employment period, as
mandated by any applicable Federal, State, or local standard. Where
no standard exists and the hazard is minimal, evaluations should be
conducted every 3 to 5 years or as frequently as recommended by an
experienced occupational health physician. Additional examinations
may be necessary if a worker develops symptoms attributable to
tert-butyl alcohol exposure. The interviews, examinations, and
medical screening tests should focus on identifying the adverse
effects of tert-butyl alcohol on the eyes, skin, or respiratory
system. Current health status should be compared with the baseline
health status of the individual worker or with expected values for a
suitable reference population.
Biological monitoring involves sampling and analyzing body tissues or
fluids to provide an index of exposure to a toxic substance or
metabolite. No biological monitoring test acceptable for routine use
has yet been developed for tert-butyl alcohol.
* Medical examinations recommended at the time of job transfer or
termination
The medical, environmental, and occupational history interviews, the
physical examination, and selected physiologic or laboratory tests
that were conducted at the time of placement should be repeated at the
time of job transfer or termination to determine the worker's medical
status at the end of his or her employment. Any changes in the
worker's health status should be compared with those expected for a
suitable reference population.
WORKPLACE MONITORING AND MEASUREMENT PROCEDURES
Determination of a worker's exposure to airborne tert-butyl alcohol is made
using charcoal tubes (100/50 mg sections, 20/40 mesh). Samples are
collected at a maximum flow rate of 0.2 liter per minute until a maximum
air volume of 10 liters is collected (for TWA monitoring) or a maximum air
volume of 3 liters is collected (for STEL monitoring). The sample is then
desorbed with carbon disulfide/2-butanol (99:1) or with carbon
disulfide/dimethylformamide (99:1) to extract the tert-butyl alcohol.
Analysis is conducted by gas chromatography using a flame ionization
detector. The limit of detection for this procedure is 0.01 mg per sample.
This method is described in the OSHA Computerized Information System
[OSHA 1990] and in NIOSH Method 1400 [Alcohols I] [NIOSH 1984].
PERSONAL HYGIENE PROCEDURES
If tert-butyl alcohol contacts the skin, workers should flush the affected
areas immediately with plenty of water for 15 minutes, followed by washing
with soap and water.
Clothing contaminated with tert-butyl alcohol should be removed
immediately, and provisions should be made for the safe removal of the
chemical from the clothing. Persons laundering the clothes should be
informed of the hazardous properties of tert-butyl alcohol, particularly
its potential to be irritating to the skin.
A worker who handles tert-butyl alcohol should thoroughly wash hands,
forearms, and face with soap and water before eating, using tobacco
products, or using toilet facilities.
Workers should not eat, drink, or use tobacco products in areas where
tert-butyl alcohol is handled, processed, or stored.
STORAGE
tert-Butyl alcohol should be stored in a cool, dry, well-ventilated area in
tightly sealed containers that are labeled in accordance with OSHA's Hazard
Communication Standard [29 CFR 1910.1200]. Containers of tert-butyl
alcohol should be protected from physical damage and should be stored
separately from strong oxidizers, strong mineral acids, strong hydrochloric
acid, heat, sparks, and open flame. Drums must be equipped with
self-closing valves, pressure-vacuum bungs, and flame arrestors. Only
nonsparking tools and equipment may be used to handle tert-butyl alcohol.
To prevent static sparks, containers of tert-butyl alcohol should be
grounded and bonded for transfers. Because containers that formerly
contained tert-butyl alcohol may still hold product residues, they should
be handled appropriately.
SPILLS AND LEAKS
In the event of a spill or leak involving tert-butyl alcohol, persons not
wearing protective equipment and clothing should be restricted from
contaminated areas until cleanup has been completed. The following steps
should be undertaken following a spill or leak:
1. Do not touch the spilled material; stop the leak if it is possible to
do so without risk.
2. Notify safety personnel.
3. Remove all sources of heat and ignition.
4. Ventilate potentially explosive atmospheres.
5. Water spray may be used to reduce vapors, but the spray may not
prevent ignition in closed spaces.
6. For small liquid spills, take up with sand or other noncombustible
absorbent material and place into closed containers for later
disposal.
7. For large liquid spills, build dikes far ahead of the spill to contain
the tert-butyl alcohol for later reclamation or disposal.
EMERGENCY PLANNING, COMMUNITY RIGHT-TO-KNOW, AND HAZARDOUS WASTE
MANAGEMENT REQUIREMENTS
The Environmental Protection Agency's (EPA's) regulatory requirements for
emergency planning, community right-to-know, and hazardous waste management
may vary over time. Users are therefore advised to determine periodically
whether new information is available.
* Emergency planning requirements
tert-Butyl alcohol is not subject to EPA emergency planning
requirements under the Superfund Amendments and Reauthorization Act
(SARA) (Title III).
* Reportable quantity requirements (releases of hazardous substances)
Employers are not required by the emergency release notification
provisions of the Comprehensive Environmental Response, Compensation,
and Liability Act (CERCLA) [40 CFR Part 355.40] to notify the National
Response Center of an accidental release of tert-butyl alcohol; there
is no reportable quantity for this substance.
* Community right-to-know requirements
Employers who own or operate facilities in SIC codes 20-39 that employ
10 or more employees and that manufacture 25,000 pounds or more of
tert-butyl alcohol per calendar year or otherwise use 10,000 pounds or
more of tert-butyl alcohol per calendar year are required by EPA
[40 CFR Part 372.30] to submit a Toxic Chemical Release Inventory form
(Form R) to EPA reporting the amount of tert-butyl alcohol emitted or
released from their facility annually.
* Hazardous waste management requirements
EPA considers a waste to be hazardous if it exhibits any of the
following characteristics: ignitability, corrosivity, reactivity, or
toxicity, as defined in 40 CFR 261.21-261.24. Under the Resource
Conservation and Recovery Act (RCRA), EPA has specifically listed many
chemical wastes as hazardous. Although tert-butyl alcohol is not
specifically listed as a hazardous waste under RCRA, EPA requires
employers to treat any waste as hazardous if it exhibits any of the
characteristics discussed above.
Providing more information about the removal and disposal of specific
chemicals is beyond the scope of this guideline. EPA, U.S. Department
of Transportation, and State and local regulations should be followed
to ensure that removal, transport, and disposal of this substance are
conducted in accordance with existing regulations. To be certain that
chemical waste disposal meets EPA regulatory requirements, employers
should address any questions to the RCRA hotline at (202) 382-3000 (in
Washington, D.C.) or toll-free at (800) 424-9346 (outside Washington,
D.C.). In addition, relevant State and local authorities should be
contacted for information on any requirements they may have for the
waste removal and disposal of this substance.
RESPIRATORY PROTECTION
* Conditions for respirator use
Good industrial hygiene practice requires that engineering controls be
used where feasible to reduce workplace concentrations of hazardous
materials to the prescribed exposure limit. However, some situations
may require the use of respirators to control exposure. Respirators
must be worn if the ambient concentration of tert-butyl alcohol
exceeds prescribed exposure limits. Respirators may be used
(1) before engineering controls have been installed, (2) during work
operations such as maintenance or repair activities that involve
unknown exposures, (3) during operations that require entry into tanks
or closed vessels, and (4) during emergency situations. If the use of
respirators is necessary, the only respirators permitted are those
that have been approved by NIOSH and the Mine Safety and Health
Administration (MSHA).
* Respiratory protection program
Employers should institute a complete respiratory protection program
that, at a minimum, complies with the requirements of OSHA's
Respiratory Protection Standard [29 CFR 1910.134]. Such a program
must include respirator selection (see Table 1), an evaluation of the
worker's ability to perform the work while wearing a respirator, the
regular training of personnel, fit testing, periodic workplace
monitoring, and regular respirator maintenance, inspection, and
cleaning. The implementation of an adequate respiratory protection
program (including selection of the correct respirator) requires that
a knowledgeable person be in charge of the program and that the
program be evaluated regularly. For additional information on the
selection and use of respirators and on the medical screening of
respirator users, consult the NIOSH Respirator Decision Logic and
the NIOSH Guide to Industrial Respiratory Protection.
Table 1 lists the respiratory protection that NIOSH recommends for
workers exposed to tert-butyl alcohol. The recommended protection may
vary over time because of changes in the exposure limit for tert-butyl
alcohol or in respirator certification requirements. Users are
therefore advised to determine periodically whether new information is
available.
PERSONAL PROTECTIVE EQUIPMENT
Protective clothing should be worn to prevent skin contact with tert-butyl
alcohol. Chemical protective clothing should be selected on the basis of
available performance data, manufacturers' recommendations, and evaluation
of the clothing under actual conditions of use. Butyl rubber has been
recommended for use against permeation by tert-butyl alcohol and may
provide protection for periods greater than 8 hours. Polyethylene
ethylene/vinyl alcohol may withstand permeation for more than 4 but fewer
than 8 hours.
If tert-butyl alcohol is dissolved in water or an organic solvent, the
permeation properties of both the solvent and the mixture must be
considered when selecting personal protective equipment and clothing.
Safety glasses, goggles, or faceshields should be worn during operations in
which tert-butyl alcohol might contact the eyes (e.g., through splashes of
solution). Eyewash fountains and emergency showers should be available
within the immediate work area whenever the potential exists for eye or
skin contact with tert-butyl alcohol. Contact lenses should not be worn if
the potential exists for tert-butyl alcohol exposure.
REFERENCES
ACGIH [1986]. Documentation of the threshold limit values and biological
exposure indices. 5th edition. Cincinnati, OH: American Conference of
Governmental Industrial Hygienists.
ACGIH [1989]. TLVs. Threshold limit values and biological exposure
indices for 1989-1990. Cincinnati, OH: American Conference of
Governmental Industrial Hygienists.
Clayton G, Clayton F [1982]. Patty's industrial hygiene and toxicology.
3rd revised edition. New York, NY: John Wiley & Sons.
[CFR] Code of Federal regulations. Title 29 (Department of Labor), Parts
1910.1000 and 1910.1200. Washington, DC: U.S. Government Printing Office,
Office of the Federal Register.
HSDB [1985]. tert-Butyl alcohol. Bethesda, MD: The Hazardous Substances
Data Bank, National Library of Medicine.
NIOSH [1984]. NIOSH manual of analytical methods. 3rd edition, Volume 1.
Cincinnati, OH: U.S. Department of Health and Human Services, Public
Health Service, Centers for Disease Control, National Institute for
Occupational Safety and Health.
NIOSH [1987a]. NIOSH guide to industrial respiratory protection.
Cincinnati, OH: U.S. Department of Health and Human Services, Public
Health Service, Centers for Disease Control, National Institute for
Occupational Safety and Health. DHHS (NIOSH) Publication No. 87-116.
NIOSH [1987c]. Respirator decision logic. Cincinnati, OH:
U.S. Department of Health and Human Services, Public Health Service,
Centers for Disease Control, National Institute for Occupational Safety and
Health. DHHS (NIOSH) Publication No. 87-108.
NIOSH [1988]. Testimony of the National Institute for Occupational Safety
and Health on the Occupational Safety and Health Administration's proposed
rule: 29 CFR 1910, Docket No. H-020, August 2, 1988. NIOSH policy
statements. Cincinnati, OH: U.S. Department of Health and Human Services,
Public Health Service, Centers for Disease Control, National Institute for
Occupational Safety and Health.
OSHA [1990]. Computerized information system. Washington, DC: U.S.
Department of Labor, Occupational Safety and Health Administration.
Proctor NH, Hughes JP, Fischman ML [1988]. Chemical hazards of the
workplace. Philadelphia, PA: J.B. Lippincott Company.
RTECS [1990]. tert-Butyl alcohol. Bethesda, MD: Registry of Toxic
Effects of Chemical Substances, National Library of Medicine.
BIBLIOGRAPHY
ACGIH [1986]. Documentation of the threshold limit values and biological
exposure indices. 5th edition. Cincinnati, OH: American Conference of
Governmental Industrial Hygienists.
AIHA [1989]. Odor thresholds for chemicals with established occupational
health standards. Akron, OH: American Industrial Hygiene Association.
Clayton G, Clayton F [1982]. Patty's industrial hygiene and toxicology.
3rd revised edition. New York, NY: John Wiley & Sons.
[CFR] Code of Federal Regulations. Title 49 (Department of
Transportation). Washington, DC: U.S. Government Printing Office, Office
of the Federal Register.
DOT [1987]. 1987 Emergency response guidebook, guide 26. Washington, DC:
U.S. Department of Transportation, Office of Hazardous Materials
Transportation, Research and Special Programs Administration.
Forsberg K, Mansdorf SZ [1989]. Quick selection guide to chemical
protective clothing. New York, NY: Van Nostrand Reinhold.
Hawley's condensed chemical dictionary [1987]. Sax NI, Lewis RJ. 11th
edition. New York, NY: Van Nostrand Reinhold Company.
Hazardous Substance Fact Sheet [1985]. tert-Butyl alcohol. Trenton, NJ:
New Jersey Department of Health.
HSDB [1985]. tert-Butyl alcohol. Bethesda, MD: The Hazardous Substances
Data Bank, National Library of Medicine.
Material Safety Data Sheet No. 497 [1986]. Schenectady, NY: Genium
Publishing Corporation.
Merck Index [1983]. Windholz M. 10th edition. Rahway, NJ: Merck &
Company.
NFPA [1986]. Fire protection guide on hazardous materials. 9th edition.
Quincy, MA: National Fire Protection Association.
NIOSH [1987b]. NIOSH pocket guide to chemical hazards. Cincinnati, OH:
U.S. Department of Health and Human Services, Public Health Service,
Centers for Disease Control, National Institute for Occupational Safety and
Health. DHHS (NIOSH) Publication No. 85-114.
Proctor NH, Hughes JP [1978]. Chemical hazards of the workplace.
Philadelphia, PA: J.B. Lippincott Company.
RTECS [1990]. tert-Butyl alcohol. Bethesda, MD: Registry of Toxic
Effects of Chemical Substances, National Library of Medicine.
Sittig M [1985]. Handbook of toxic and hazardous chemicals. 2nd edition.
Park Ridge, NJ: Noyes Publications.
USCG [1984]. CHRIS (chemical hazards response information system)
hazardous chemical data manual: tert-Butyl alcohol. Washington, DC: U.S.
Department of Transportation, U.S. Coast Guard, Commandant Instruction
M16465.12A.
Table 1. NIOSH recommended respiratory protection for workers exposed to tert-butyl alcohol*
Condition |
Minimum respiratory protection** |
Airborne concentration of tert-butyl alcohol: |
100 to 1000(+) ppm (10 × PEL) |
Any supplied-air respirator equipped
with a half mask and operated in a
demand (negative-pressure) mode |
100 to 2500 ppm (25 × PEL) |
Any supplied-air respirator equipped
with a hood or helmet and operated in a
continuous-flow mode |
100 to 5000(++) ppm (50 × PEL) |
Any supplied-air respirator equipped
with a full facepiece and operated in a
demand (negative-pressure) mode, or
Any supplied-air respirator equipped
with a tight-fitting facepiece and
operated in a continuous-flow mode, or
Any self-contained respirator
equipped with a full facepiece and
operated in a demand (negative-pressure)
mode, or
Any supplied-air respirator operated in
a pressure-demand or other
positive-pressure mode |
Entry into unknown concentrations |
Any self-contained respirator equipped
with a full facepiece and operated in a
pressure-demand or other
positive-pressure mode, or
Any supplied-air respirator equipped
with a full facepiece and operated in a
pressure-demand or other
positive-pressure mode in combination
with an auxiliary self-contained
breathing apparatus operated in a
pressure-demand or other
positive-pressure mode |
Firefighting |
Any self-contained respirator equipped
with a full facepiece and operated in a
pressure-demand or other
positive-pressure mode |
Escape |
Any air-purifying, full-facepiece
respirator equipped with an organic
vapor canister, or
Any escape-type, self-contained
breathing apparatus with a suitable
service life (number of minutes required
to escape the environment) |
* The OSHA PEL is 100 ppm (300 mg/m3) as an 8-hour TWA. No NIOSH REL
has been issued.
** Only NIOSH/MSHA-approved equipment should be used. Also note the
following:
1. Respirators accepted for use at higher concentrations may be used at
lower concentrations; respirators must not, however, be used at
concentrations higher than those for which they are approved.
2. Air-purifying respirators may not be used in oxygen-deficient
atmospheres.
(+) tert-Butyl alcohol is reported to cause eye irritation or damage; eye
protection may be required.
(++) Represents 25 percent of the lower explosive limit.
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