Bibliographic Citation
| Document | For copies of Journal Articles, please contact the Publisher or your local public or university library and refer to the information in the Resource Relation field. For copies of other documents, please see the Availability, Publisher, Research Organization, Resource Relation and/or Author (affiliation information) fields and/or Document Availability. |
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| Title | Sexual dimorphism in adrenergic regulation of hepatic glycogenolysis |
| Creator/Author | Studer, R.K. |
| Publication Date | 1987 Apr 01 |
| OSTI Identifier | OSTI ID: 5716306 |
| Other Number(s) | CODEN: AJPHA |
| Resource Type | Journal Article |
| Resource Relation | Am. J. Physiol. ; Vol/Issue: 252:4 |
| Research Org | Univ. of Pittsburgh, PA |
| Subject | 551001 -- Physiological Systems-- Tracer Techniques; CALCIUM 45-- MEMBRANE TRANSPORT;ESTROUS CYCLE-- PHYSIOLOGY;LIVER CELLS-- ENZYME ACTIVITY; ADRENALINE;DOSE-RESPONSE RELATIONSHIPS;ESTRADIOL;FEMALES;GLUCOSE;GLYCOGEN;MALES;PHOSPHOTRANSFERASES;PROGESTERONE;SEX DEPENDENCE |
| Related Subject | ADRENAL HORMONES;ALDEHYDES;ALKALINE EARTH ISOTOPES;ANIMAL CELLS;AUTONOMIC NERVOUS SYSTEM AGENTS;BETA DECAY RADIOISOTOPES;BETA-MINUS DECAY RADIOISOTOPES;CALCIUM ISOTOPES;CARBOHYDRATES;CARDIOTONICS;CARDIOVASCULAR AGENTS;DAYS LIVING RADIOISOTOPES;DRUGS;ENZYMES;ESTRANES;ESTROGENS;EVEN-ODD NUCLEI;HEXOSES;HORMONES;HYDROXY COMPOUNDS;INTERMEDIATE MASS NUCLEI;ISOTOPES;KETONES;MONOSACCHARIDES;NEUROREGULATORS;NUCLEI;ORGANIC COMPOUNDS;PHOSPHORUS-GROUP TRANSFERASES;POLYSACCHARIDES;PREGNANES;RADIOISOTOPES;SACCHARIDES;SOMATIC CELLS;STEROID HORMONES;STEROIDS;SYMPATHOMIMETICS;TRANSFERASES |
| Description/Abstract | The total phosphorylase a plus b of hepatocytes isolated from females and incubated in the absence or presence of estradiol and progesterone at concentrations found in vivo does not vary during the estrous cycle.^However, there is a slight but significant influence of the estrous cycle on basal and epinephrine-stimulated phosphorylase a activity, with a nadir being seen on diestrus.^The relative contributions of the ..cap alpha..- and ..beta..-mediated pathways to phosphorylase a activation do not vary with the estrous cycle but are constant at 75 and 56%, respectively, of the response to 5 x 10/sup -8/ M epinephrine.^When the epinephrine-stimulated glucose release from glycogen stores in cells from females and males is compared, the release from the female is greater than that from the male, while the ..cap alpha..-receptor-mediated stimulation in the female is comparable with that in the male.^The epinephrine-stimulated increase in cytostolic free calcium (Ca/sub i/) is greater in the male than the female at 10/sup -6/ M but greater in the female than the male at 5 x 10/sup -9/ M. The changes in Ca/sub i/ are equivalent at intermediate epinephrine concentrations.^When considered with the prior analysis of /sup 45/Ca efflux after adrenergic stimulation, this suggests there may be a sexual dimorphism in hepatocyte calcium transport systems.^The glucose release for a given increase in Ca/sub i/ is greater in the female than the male probably due to the concomitant action of the ..beta..-mediated increase in cAMP and the ..cap alpha..-mediated increase in Ca/sub i/.^This supports the conclusion that the ..beta..-mediated component does make a significant contribution to the catecholamine regulation of glycogenolysis in hepatocytes from adult female rats. |
| Country of Publication | United States |
| Language | English |
| Format | Pages: E467-E476 |
| System Entry Date | 2001 May 13 |
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