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 EC-number:  1.1.1.49 ----- glucose-6-phosphate dehydrogenase
EC-NUMBER 1.1.1.49
ENZYME-NAME glucose-6-phosphate dehydrogenase
ENZYME-SYSNAME Also acts slowly on beta-D-glucose and other sugars. Certain preparations reduce NAD+ as well as NADP+.
ENZYME-CLASS Oxidoreductases Acting on the CH-OH group of donors With NAD+ or NADP+ as acceptor
SYNONYMS 6-phosphoglucose dehydrogenase;; D-glucose 6-phosphate dehydrogenase;; Entner-Doudoroff enzyme;; G6PDH;;   >>more synonyms
REACTION D-glucose 6-phosphate + NADP+ = D-glucono-1,5-lactone 6-phosphate + NADPH + H+ [RN:R00835]
PATHWAY EMP-PATHWAYS: ''alpha''-Glucose--Ethanol_Catabolism_(outer_membrane,_periplasm,_plasma_membrane)_(via_EC_4.2.1.14/4.1.1.1);   >>more EMP pathways
KEGG-PATHWAYS: Pentose phosphate pathway; Glutathione metabolism;   >>more KEGG pathways
GO_TERM GO:0004345:glucose-6-phosphate 1-dehydrogenase activity
ENZYME-COMMENT D-glucose-6-phosphate:NADP+ 1-oxidoreductase
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ExternalDB ----- DBLINKS
Diseases
Structure
Gene
Motif
Ortholog
Literature
Other
InterPro Domains found in sequences annotated as EC 1.1.1.49
   IPR000169 Peptidase, cysteine peptidase active site
   IPR000886 Endoplasmic reticulum targeting sequence
   IPR000977 ATP-dependent DNA ligase
   IPR001005 Myb, DNA-binding
   IPR001282 Glucose-6-phosphate dehydrogenase
   IPR001412 Aminoacyl-tRNA synthetase, class I
   IPR002047 Adipokinetic hormone
   IPR002088 Protein prenyltransferase, alpha subunit
   IPR005900 6-phosphogluconolactonase
   IPR006089 Acyl-CoA dehydrogenase
   IPR006148 Glucosamine/galactosamine-6-phosphate isomerase
       
PIR SuperFamilies containing EC 1.1.1.49
SF000110 glucose-6-phosphate dehydrogenase
SF005370 yeast SOL3 protein
Taxonomic breakdown of EC 1.1.1.49 sequences
To perform phylogenetic analysis, first select some protein ids by clicking on their checkboxes, then click on one of the buttons below.
  Additional gi numbers:   
Bacteria
uncultured bacterium 581
40063486
IPR001282 Glucose-6-phosphate dehydrogenase
Actinobacteria
Actinobacteria (class)
Corynebacterium diphtheriae
38200151
IPR001282 Glucose-6-phosphate dehydrogenase
Corynebacterium efficiens
23492378
IPR001282 Glucose-6-phosphate dehydrogenase
23493536
IPR001282 Glucose-6-phosphate dehydrogenase
Corynebacterium glutamicum
21324344
IPR001282 Glucose-6-phosphate dehydrogenase
Corynebacterium jeikeium
68263670
IPR001282 Glucose-6-phosphate dehydrogenase
Leifsonia xyli
50954824
IPR001282 Glucose-6-phosphate dehydrogenase
Mycobacterium bovis
31792315
IPR001282 Glucose-6-phosphate dehydrogenase
31792641
IPR001282 Glucose-6-phosphate dehydrogenase
Mycobacterium leprae
2052115
IPR001282 Glucose-6-phosphate dehydrogenase
13092777
IPR005900 6-phosphogluconolactonase
IPR006148 Glucosamine/galactosamine-6-phosphate isomerase
Mycobacterium tuberculosis
31792315
IPR001282 Glucose-6-phosphate dehydrogenase
31792641
IPR001282 Glucose-6-phosphate dehydrogenase
Nocardia farcinica
54025545
IPR001282 Glucose-6-phosphate dehydrogenase
Nonomuraea sp. ATCC 39727
38153689
IPR001282 Glucose-6-phosphate dehydrogenase
Propionibacterium acnes
50843037
IPR001282 Glucose-6-phosphate dehydrogenase
Propionibacterium freudenreichii
76556225
IPR001282 Glucose-6-phosphate dehydrogenase
Streptomyces avermitilis
29828310
IPR001282 Glucose-6-phosphate dehydrogenase
29832855
IPR001282 Glucose-6-phosphate dehydrogenase
Streptomyces coelicolor
21218883
IPR001282 Glucose-6-phosphate dehydrogenase
21220423
IPR001282 Glucose-6-phosphate dehydrogenase
21224957
IPR001282 Glucose-6-phosphate dehydrogenase
Thermobifida fusca
72162404
IPR001282 Glucose-6-phosphate dehydrogenase
Tropheryma whipplei
28493310
IPR001282 Glucose-6-phosphate dehydrogenase
Aquificae
Aquificae (class)
Aquifex aeolicus
28974707
IPR001282 Glucose-6-phosphate dehydrogenase
Chlamydiae
Chlamydiae (class)
Candidatus Protochlamydia amoebophila
46400096
IPR001282 Glucose-6-phosphate dehydrogenase
Chlamydia muridarum
14194761
IPR001282 Glucose-6-phosphate dehydrogenase
Chlamydia trachomatis
1791245
IPR001282 Glucose-6-phosphate dehydrogenase
15604905
IPR001282 Glucose-6-phosphate dehydrogenase
76788907
IPR001282 Glucose-6-phosphate dehydrogenase
Chlamydophila pneumoniae
16752800
IPR001282 Glucose-6-phosphate dehydrogenase
Chlorobi
Chlorobia
Chlorobaculum tepidum
21674685
IPR001282 Glucose-6-phosphate dehydrogenase
Chlorobium chlorochromatii
78189625
Pelodictyon luteolum
78186195
Cyanobacteria
Anabaena variabilis
75812811
IPR001282 Glucose-6-phosphate dehydrogenase
75907903
IPR001282 Glucose-6-phosphate dehydrogenase
Nostoc sp. PCC 7120
17133154
IPR001282 Glucose-6-phosphate dehydrogenase
Prochlorococcus marinus
33640822
IPR001282 Glucose-6-phosphate dehydrogenase
33861630
IPR001282 Glucose-6-phosphate dehydrogenase
72382515
IPR001282 Glucose-6-phosphate dehydrogenase
78779468
Synechococcus elongatus
232125
IPR001282 Glucose-6-phosphate dehydrogenase
56751777
IPR001282 Glucose-6-phosphate dehydrogenase
Synechococcus sp. CC9605
78213435
Synechococcus sp. CC9902
78184325
Synechococcus sp. WH 8102
33632453
IPR001282 Glucose-6-phosphate dehydrogenase
Synechocystis sp. PCC 6803
16330043
IPR001282 Glucose-6-phosphate dehydrogenase
Gloeobacteria
Gloeobacter violaceus
35211734
IPR001282 Glucose-6-phosphate dehydrogenase
35213749
IPR001282 Glucose-6-phosphate dehydrogenase
IPR006089 Acyl-CoA dehydrogenase
Firmicutes
Bacilli
Bacillus cereus
42738391
IPR001282 Glucose-6-phosphate dehydrogenase
Bacillus subtilis
1303961
IPR001282 Glucose-6-phosphate dehydrogenase
Geobacillus kaustophilus
56420869
IPR001282 Glucose-6-phosphate dehydrogenase
Lactobacillus acidophilus
58336750
IPR001282 Glucose-6-phosphate dehydrogenase
Lactobacillus plantarum
28379186
IPR001282 Glucose-6-phosphate dehydrogenase
Lactobacillus sakei
81427995
Lactobacillus sanfranciscensis
73476080
IPR001282 Glucose-6-phosphate dehydrogenase
Lactococcus lactis
15674202
IPR001282 Glucose-6-phosphate dehydrogenase
Leuconostoc mesenteroides
120732
IPR001282 Glucose-6-phosphate dehydrogenase
Listeria monocytogenes
16411431
IPR001282 Glucose-6-phosphate dehydrogenase
46908206
IPR001282 Glucose-6-phosphate dehydrogenase
Oceanobacillus iheyensis
23100393
IPR001282 Glucose-6-phosphate dehydrogenase
Staphylococcus aureus
49483755
IPR001282 Glucose-6-phosphate dehydrogenase
Staphylococcus epidermidis
57866979
IPR001282 Glucose-6-phosphate dehydrogenase
Streptococcus pneumoniae
15458749
IPR001282 Glucose-6-phosphate dehydrogenase
15901104
IPR001282 Glucose-6-phosphate dehydrogenase
Clostridia
Clostridium tetani
28211501
IPR001282 Glucose-6-phosphate dehydrogenase
Planctomycetes
Planctomycetacia
Rhodopirellula baltica
32397500
IPR001282 Glucose-6-phosphate dehydrogenase
Proteobacteria
Alphaproteobacteria
Brucella melitensis
17984682
IPR001282 Glucose-6-phosphate dehydrogenase
23464145
IPR001282 Glucose-6-phosphate dehydrogenase
Gluconacetobacter hansenii
237460
Gluconobacter oxydans
58038630
IPR001282 Glucose-6-phosphate dehydrogenase
Nitrobacter winogradskyi
75676827
IPR001282 Glucose-6-phosphate dehydrogenase
Rhodobacter sphaeroides
77463285
IPR001282 Glucose-6-phosphate dehydrogenase
Rhodopseudomonas palustris
39936698
IPR001282 Glucose-6-phosphate dehydrogenase
Silicibacter pomeroyi
56678653
IPR001282 Glucose-6-phosphate dehydrogenase
56679603
IPR001282 Glucose-6-phosphate dehydrogenase
Sinorhizobium meliloti
15073634
IPR001282 Glucose-6-phosphate dehydrogenase
Zymomonas mobilis
11095425
IPR001282 Glucose-6-phosphate dehydrogenase
Betaproteobacteria
Burkholderia pseudomallei
67638095
IPR001282 Glucose-6-phosphate dehydrogenase
Burkholderia sp. 383
78061094
78065542
Chromobacterium violaceum
34495600
IPR001282 Glucose-6-phosphate dehydrogenase
Cupriavidus necator
73539151
IPR001282 Glucose-6-phosphate dehydrogenase
73541340
IPR001282 Glucose-6-phosphate dehydrogenase
Neisseria gonorrhoeae
59801135
IPR001282 Glucose-6-phosphate dehydrogenase
Neisseria meningitidis
7380251
IPR001282 Glucose-6-phosphate dehydrogenase
15677253
IPR001282 Glucose-6-phosphate dehydrogenase
Nitrosomonas europaea
30248415
IPR000886 Endoplasmic reticulum targeting sequence
IPR001282 Glucose-6-phosphate dehydrogenase
Ralstonia solanacearum
17432033
IPR001282 Glucose-6-phosphate dehydrogenase
Deltaproteobacteria
Desulfovibrio desulfuricans
78358510
Epsilonproteobacteria
Helicobacter pylori
15612092
IPR001282 Glucose-6-phosphate dehydrogenase
15645715
IPR001282 Glucose-6-phosphate dehydrogenase
15645716
IPR005900 6-phosphogluconolactonase
Gammaproteobacteria
Actinobacillus actinomycetemcomitans
2494654
IPR001282 Glucose-6-phosphate dehydrogenase
Buchnera aphidicola
15616929
IPR001282 Glucose-6-phosphate dehydrogenase
21672588
IPR001282 Glucose-6-phosphate dehydrogenase
27904190
IPR001282 Glucose-6-phosphate dehydrogenase
Candidatus Blochmannia floridanus
33519903
IPR001282 Glucose-6-phosphate dehydrogenase
Colwellia psychrerythraea
71278552
IPR001282 Glucose-6-phosphate dehydrogenase
Erwinia chrysanthemi
397854
IPR001282 Glucose-6-phosphate dehydrogenase
Escherichia coli
1736495
IPR001282 Glucose-6-phosphate dehydrogenase
15802265
IPR001282 Glucose-6-phosphate dehydrogenase
Haemophilus influenzae
16272501
IPR000977 ATP-dependent DNA ligase
IPR001282 Glucose-6-phosphate dehydrogenase
68057353
IPR001282 Glucose-6-phosphate dehydrogenase
Mannheimia succiniciproducens
52306123
IPR001282 Glucose-6-phosphate dehydrogenase
Nitrosococcus oceani
77164290
IPR001282 Glucose-6-phosphate dehydrogenase
77165527
IPR001282 Glucose-6-phosphate dehydrogenase
Photobacterium profundum
54308635
IPR001282 Glucose-6-phosphate dehydrogenase
Pseudoalteromonas haloplanktis
77360083
IPR001282 Glucose-6-phosphate dehydrogenase
Pseudomonas aeruginosa
2935661
IPR001282 Glucose-6-phosphate dehydrogenase
Pseudomonas fluorescens
70730508
IPR001282 Glucose-6-phosphate dehydrogenase
70731952
IPR001282 Glucose-6-phosphate dehydrogenase
Pseudomonas putida
11121549
IPR001282 Glucose-6-phosphate dehydrogenase
IPR002047 Adipokinetic hormone
Pseudomonas savastanoi
71734196
IPR001282 Glucose-6-phosphate dehydrogenase
Pseudomonas syringae
63255078
IPR001282 Glucose-6-phosphate dehydrogenase
63256926
IPR001282 Glucose-6-phosphate dehydrogenase
Salmonella enterica
29141472
Salmonella typhimurium
16420422
IPR001282 Glucose-6-phosphate dehydrogenase
Thiomicrospira crunogena
78485558
Vibrio fischeri
59713651
IPR001282 Glucose-6-phosphate dehydrogenase
Vibrio vulnificus
37679789
IPR001282 Glucose-6-phosphate dehydrogenase
Xanthomonas campestris
78047793
78049724
Yersinia pestis
77635422
IPR001282 Glucose-6-phosphate dehydrogenase
Spirochaetes
Spirochaetes (class)
Borrelia burgdorferi
15594567
15594981
IPR001282 Glucose-6-phosphate dehydrogenase
Borrelia garinii
51573461
IPR001282 Glucose-6-phosphate dehydrogenase
Treponema pallidum
15639469
IPR001282 Glucose-6-phosphate dehydrogenase
Thermotogae
Thermotogae (class)
Thermotoga maritima
4981703
IPR001282 Glucose-6-phosphate dehydrogenase
Eukaryota
Dictyostelium discoideum
28829864
IPR001282 Glucose-6-phosphate dehydrogenase
Leishmania amazonensis
27434608
IPR001282 Glucose-6-phosphate dehydrogenase
Leishmania braziliensis
27434614
IPR001282 Glucose-6-phosphate dehydrogenase
27434630
Leishmania guyanensis
27434612
IPR001282 Glucose-6-phosphate dehydrogenase
Leishmania lainsoni
27434620
IPR001282 Glucose-6-phosphate dehydrogenase
Leishmania mexicana
27434610
IPR001282 Glucose-6-phosphate dehydrogenase
Leishmania naiffi
27434616
IPR001282 Glucose-6-phosphate dehydrogenase
Leishmania panamensis
27434622
IPR001282 Glucose-6-phosphate dehydrogenase
Leishmania peruviana
27434624
IPR001282 Glucose-6-phosphate dehydrogenase
Leishmania shawi
27434618
IPR001282 Glucose-6-phosphate dehydrogenase
Leishmania tarentolae
27434626
IPR001282 Glucose-6-phosphate dehydrogenase
Trypanosoma brucei
10045209
IPR001282 Glucose-6-phosphate dehydrogenase
70832170
Trypanosoma cruzi
71666196
IPR001282 Glucose-6-phosphate dehydrogenase
Bangiophyceae
Cyanidium caldarium
5734372
IPR001282 Glucose-6-phosphate dehydrogenase
Apicomplexa
Plasmodium falciparum
438212
IPR001282 Glucose-6-phosphate dehydrogenase
Theileria parva
68350539
IPR001282 Glucose-6-phosphate dehydrogenase
Arthropoda
Insecta
Ceratitis capitata
460877
IPR001282 Glucose-6-phosphate dehydrogenase
Culex pipiens
3023805
IPR001282 Glucose-6-phosphate dehydrogenase
Drosophila melanogaster
157470
15292469
IPR001282 Glucose-6-phosphate dehydrogenase
24643350
Drosophila simulans
3023806
IPR001282 Glucose-6-phosphate dehydrogenase
Drosophila yakuba
3023810
IPR001282 Glucose-6-phosphate dehydrogenase
Hyalophora cecropia
3023807
IPR001282 Glucose-6-phosphate dehydrogenase
Sarcophaga bullata
3023808
IPR001282 Glucose-6-phosphate dehydrogenase
Ascomycota
Eurotiomycetes
Aspergillus niger
870831
IPR001282 Glucose-6-phosphate dehydrogenase
Emericella nidulans
1523786
IPR001282 Glucose-6-phosphate dehydrogenase
Saccharomycetes
Candida glabrata
50291211
IPR001282 Glucose-6-phosphate dehydrogenase
Debaryomyces hansenii
49653795
IPR001282 Glucose-6-phosphate dehydrogenase
Eremothecium gossypii
45185024
IPR001282 Glucose-6-phosphate dehydrogenase
Kluyveromyces lactis
5539
IPR001282 Glucose-6-phosphate dehydrogenase
Pichia jadinii
299248
IPR001282 Glucose-6-phosphate dehydrogenase
Saccharomyces cerevisiae
6324088
IPR001282 Glucose-6-phosphate dehydrogenase
Schizosaccharomycetes
Schizosaccharomyces pombe
2462688
IPR001282 Glucose-6-phosphate dehydrogenase
3150114
IPR001282 Glucose-6-phosphate dehydrogenase
6014420
IPR001282 Glucose-6-phosphate dehydrogenase
Chlorophyta
Chlorophyceae
Dunaliella bioculata
5734379
IPR001282 Glucose-6-phosphate dehydrogenase
Trebouxiophyceae
Chlorella vulgaris
21262179
IPR001282 Glucose-6-phosphate dehydrogenase
Chordata
Actinopterygii
Platichthys flesus
12641794
IPR001282 Glucose-6-phosphate dehydrogenase
Takifugu rubripes
5459313
IPR001282 Glucose-6-phosphate dehydrogenase
Mammalia
Bos indicus
31873226
IPR001282 Glucose-6-phosphate dehydrogenase
32168631
IPR001282 Glucose-6-phosphate dehydrogenase
32264081
IPR001282 Glucose-6-phosphate dehydrogenase
56266588
IPR001282 Glucose-6-phosphate dehydrogenase
Cricetulus griseus
62510568
IPR001282 Glucose-6-phosphate dehydrogenase
Homo sapiens
120731
IPR001282 Glucose-6-phosphate dehydrogenase
1203978
Macropus robustus
2494652
IPR001282 Glucose-6-phosphate dehydrogenase
Mus musculus
6996917
IPR001282 Glucose-6-phosphate dehydrogenase
13937389
IPR001282 Glucose-6-phosphate dehydrogenase
Ovis aries
22797198
IPR001282 Glucose-6-phosphate dehydrogenase
Rattus norvegicus
8393381
IPR001282 Glucose-6-phosphate dehydrogenase
Microsporidia
Encephalitozoon cuniculi
19171098
IPR001282 Glucose-6-phosphate dehydrogenase
Nematoda
Chromadorea
Caenorhabditis elegans
3873703
IPR001282 Glucose-6-phosphate dehydrogenase
Phaeophyceae
Laminaria digitata
6453559
IPR001282 Glucose-6-phosphate dehydrogenase
Streptophyta
Arabidopsis thaliana
1166405
5732195
5732197
9294223
IPR001282 Glucose-6-phosphate dehydrogenase
9758370
IPR001282 Glucose-6-phosphate dehydrogenase
15221719
IPR001282 Glucose-6-phosphate dehydrogenase
20466191
IPR001282 Glucose-6-phosphate dehydrogenase
21436353
IPR001282 Glucose-6-phosphate dehydrogenase
22326761
IPR001282 Glucose-6-phosphate dehydrogenase
Betula pendula
6723465
IPR001282 Glucose-6-phosphate dehydrogenase
Glycine max
3452137
IPR001282 Glucose-6-phosphate dehydrogenase
Malus x domestica
33772279
IPR001282 Glucose-6-phosphate dehydrogenase
Medicago sativa
3023815
IPR001282 Glucose-6-phosphate dehydrogenase
Mesembryanthemum crystallinum
4206114
IPR001282 Glucose-6-phosphate dehydrogenase
Nicotiana tabacum
1480344
IPR001282 Glucose-6-phosphate dehydrogenase
3021532
IPR001282 Glucose-6-phosphate dehydrogenase
9392607
IPR001282 Glucose-6-phosphate dehydrogenase
Petroselinum crispum
2352919
IPR001282 Glucose-6-phosphate dehydrogenase
2352921
IPR001282 Glucose-6-phosphate dehydrogenase
2352923
IPR001282 Glucose-6-phosphate dehydrogenase
Solanum tuberosum
471345
IPR001282 Glucose-6-phosphate dehydrogenase
1197385
IPR001282 Glucose-6-phosphate dehydrogenase
5734502
IPR001282 Glucose-6-phosphate dehydrogenase
Spinacia oleracea
2276344
IPR001282 Glucose-6-phosphate dehydrogenase
2276346
IPR001282 Glucose-6-phosphate dehydrogenase
2276348
IPR001282 Glucose-6-phosphate dehydrogenase
Liliopsida
Oryza sativa
50925289
IPR001282 Glucose-6-phosphate dehydrogenase
  Additional gi numbers:   

To perform phylogenetic analysis:

  1. Select some ids by clicking on their checkboxes.
  2. Click on one of the buttons above.