LOCUS       NP_956068                364 aa            linear   VRT 26-SEP-2007
DEFINITION  dual specificity phosphatase 7 [Danio rerio].
ACCESSION   NP_956068 XP_685262
VERSION     NP_956068.2  GI:76253883
DBSOURCE    REFSEQ: accession NM_199774.2
KEYWORDS    .
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Cyprinidae; Danio.
REFERENCE   1  (residues 1 to 364)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002)
   PUBMED   12477932
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC066600.1.
            On Sep 25, 2005 this sequence version replaced gi:41054273.
FEATURES             Location/Qualifiers
     source          1..364
                     /organism="Danio rerio"
                     /db_xref="taxon:7955"
                     /chromosome="11"
                     /map="11"
     Protein         1..364
                     /product="dual specificity phosphatase 7"
                     /note="dual specificity phosphatase 6"
                     /calculated_mol_wt=40270
     Region          3..133
                     /region_name="DSP_MapKP"
                     /note="N-terminal regulatory rhodanese domain of dual
                     specificity phosphatases (DSP), such as Mapk Phosphatase.
                     This domain is believed to determine substrate specificity
                     by binding the substrate, such as ERK2, and activating the
                     C-terminal catalytic domain...; cd01446"
                     /db_xref="CDD:29077"
     Site            49..51
                     /site_type="other"
                     /note="putative substrate binding residues"
                     /db_xref="CDD:29077"
     Region          190..327
                     /region_name="DSPc"
                     /note="Dual specificity phosphatases (DSP); Ser/Thr and
                     Tyr protein phosphatases. Structurally similar to
                     tyrosine-specific phosphatases but with a shallower active
                     site cleft and a distinctive active site signature motif,
                     HCxxGxxR. Characterized as VHR- or...; cd00127"
                     /db_xref="CDD:29029"
     Site            order(245,275..276,279,282..283)
                     /site_type="active"
                     /db_xref="CDD:29029"
     Site            order(245,276)
                     /site_type="other"
                     /note="catalytic residues"
                     /db_xref="CDD:29029"
     CDS             1..364
                     /gene="dusp7"
                     /gene_synonym="fd19d04"
                     /gene_synonym="zgc:55957"
                     /gene_synonym="zgc:77211"
                     /gene_synonym="wu:fd19d04"
                     /coded_by="NM_199774.2:249..1343"
                     /GO_component="GO:0005575 - cellular_component [Evidence
                     ND]"
                     /GO_function="GO:0017017 - MAP kinase phosphatase activity
                     [Evidence IEA]; GO:0004721 - phosphoprotein phosphatase
                     activity [Evidence IEA]; GO:0008138 - protein
                     tyrosine/serine/threonine phosphatase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006470 - protein amino acid
                     dephosphorylation [Evidence IEA]"
                     /db_xref="GeneID:327246"
                     /db_xref="ZFIN:ZDB-GENE-030131-5457"
ORIGIN      
        1 mssksaewlq edlqagggsl llldcrphel fesshiesai nlaipglmlr rlkkgnlpir
       61 siipnnedke kfvkrcktdt vllydeataa wpesgsagsv lgllmqklrd dgckafyleg
      121 gfnkfqteyp ehcetnldcs cpsssppssv lglgglriss dcsdgesdre pgsatesegs
      181 plpnnqpafp vqilpylylg cakdstnldv lgkynikyil nvtpnlpnmf ehdgefkykq
      241 ipisdhwsqn lsqffpeais fidearsqkc gilvhclagi srsvtvtvay lmqklnlsln
      301 daydfvkrkk snispnfnfm gqlldfertl glnspcdnrs psdqlffttp tnhnmfqlds
      361 lest
//