(unspecified)-zu- = humaniseda | Finally, if the antibody is conjugated to a toxin an extra word is added; aritox, for example, denotes the A chain of ricin.
Let's try it. Abciximab can be parsed as follows: ab-ci-xi-mab. The -xi- denotes a chimeric antibody and the -ci- a cardiovascular target. Whoever named it was sleeping on the job — the target is actually the platelet. What about trastuzumab (Herceptin)? Well that's a humanised antibody (-zu-mab) that targets an unspecified tumour (-tu-). If you wanted to show that it targets the breast specifically, you could call it tramazumab.
Now play the game yourself. Imagine a chimeric monoclonal that targets syphilitic gummata; the stem would be -le-xi-mab. If it had six active domains, you might be tempted to call it sexileximab. I would.
Jeff Aronson
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