From: ncbi-seminar-admin@ncbi.nlm.nih.gov on behalf of Michael Galperin
[galperin@ncbi.nlm.nih.gov]
Sent: Saturday, November 17, 2001 10:30 PM
To: ncbi-seminar@ncbi.nlm.nih.gov
Subject: CBB seminar Tue at 11 am 

CBB seminars are held in the 6th Floor South Conference Room of
Building 45  (Calendar: ConfN6S).

Tuesday November 20th at 11:00 am:

Comparative analysis of metabolic and signaling pathways using complete
microbial genomes.

Michael Y. Galperin

I will present several cases of "applied genomics", where comparative
studies of the microbial genomes led to some interesting enzymological
implications and/or allowed identification of novel potential targets for
antibacterial drugs. These include a) characterization of the third forms
of fructose-1,6-bisphosphate aldolase and phosphoglycerate mutase; b) a
study of the interplay of the sodium ion cycle and proton cycle in the
energetics of bacteria and archaea; and c) characterization of novel
domains of the two-component signal transduction system. The talk will be
mostly based on three published papers (PMID: 10675594, 11528000,
11557134) and two papers still in press:
1. Galperin MY, Jedrzejas MJ (2001). Conserved core structure and active
site residues in alkaline phosphatase superfamily enzymes. Proteins 45,
318-324.
2. Galperin MY, Gaidenko TA, Mulkidjanian AY, Nakano M, Price CW (2001).
MHYT, a new integral membrane sensor domain. FEMS Microbiol. Lett. 205:
17-23.