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Actinomyces naeslundii Search Results

Record: 1 of 1  
MiniMap IGR0601.1 IGR0599 IGR0602 IGR0601.2 IGR0601 IGR0600 ANA_0910 ANA_0911 ANA_0903 ANA_0908 glnH, - ANA_0906 lipA, - ANA_0902 glnA, - ANA_0904 ANA_0910 ANA_0911 ANA_0903 ANA_0908 glnH, - ANA_0906 lipA, - ANA_0902 glnA, - ANA_0904 ANA_0910 ANA_0911 ANA_0903 ANA_0908 glnH, - ANA_0906 lipA, - ANA_0902 glnA, - ANA_0904 ANA_0909 ANA_0909


Gene ID:ANA_0908

DNA Molecule Name:
1  

GenBank ID:


Gene Name:


Definition:
ABC-type amino acid transport system, permease component

Cellular Location:
Membrane, Cytoplasm [Evidence]

Gene Start:
980101

Gene Stop:
980955

Gene Length:
855

Molecular Weight*:
31278

pI*:
9.55

Net Charge*:
7.13

EC:
 

Functional Class:

Gene Ontology:
Biological process
  GO:0006355    regulation of transcription, DNA-dependent
  GO:0006810    transport

Cellular component
  GO:0009276    1-2nm peptidoglycan-based cell wall
  GO:0016020    membrane
  GO:0016021    integral to membrane

Molecular function
  GO:0003700    transcription factor activity
  GO:0005215    transporter activity


Pathway: pathway table

Secondary Evidence:
Osuna R., Lienau D., Hughes K.T., Johnson R.C.
Sequence, regulation, and functions of fis in Salmonella typhimurium.
J. Bacteriol. 1995. 177(8):2021-2032.
PMID: 7536730

Wilson R.L., Libby S.J., Freet A.M., Boddicker J.D., Fahlen T.F., Jones B.D.
Fis, a DNA nucleoid-associated protein, is involved in Salmonella typhimurium SPI-1 invasion gene expression.
Mol. Microbiol. 2001. 39(1):79-88.
PMID: 11123690

Goldberg M.D., Johnson M., Hinton J.C., Williams P.H.
Role of the nucleoid-associated protein Fis in the regulation of virulence properties of enteropathogenic Escherichia coli.
Mol. Microbiol. 2001. 41(3):549-559.
PMID: 11532124

Morett E., Bork P.
Evolution of new protein function: recombinational enhancer Fis originated by horizontal gene transfer from the transcriptional regulator NtrC.
FEBS Lett. 1998. 433(1):108-112.
PMID: 9738943

Kostrewa D., Granzin J., Stock D., Choe H.W., Labahn J., Saenger W.
Crystal structure of the factor for inversion stimulation FIS at 2.0 A resolution.
J. Mol. Biol. 1992. 226(1):209-226.
PMID: 1619650

Cheng Y.S., Yang W.Z., Johnson R.C., Yuan H.S.
Structural analysis of the transcriptional activation on Fis: crystal structures of six Fis mutants with different activation properties.
J. Mol. Biol. 2000. 302(5):1139-1151.
PMID: 11183780



Comment:


View in HOMD Genome Viewer

Blast Summary:  PSI-Blast Search


Top Blast Hits:  Updated monthly
Click here to view the entire PsiBlast results.
 gi|154508733|ref|ZP_02044375.1|  hypothetical protein ACTODO...   295   2e-78
 gi|23465743|ref|NP_696346.1|  permease protein of ABC transp...   286   9e-76
 gi|23335783|ref|ZP_00121016.1|  COG0765: ABC-type amino acid...   286   1e-75
 gi|119025489|ref|YP_909334.1|  permease protein of ABC trans...   285   3e-75
 gi|54023858|ref|YP_118100.1|  putative ABC transporter perme...   256   1e-66
 gi|111017996|ref|YP_700968.1|  ABC amino acid transporter, p...   255   2e-66
 gi|118470944|ref|YP_887549.1|  ABC-type amino acid transport...   253   1e-65
 gi|145224166|ref|YP_001134844.1|  polar amino acid ABC trans...   250   5e-65
 gi|68535882|ref|YP_250587.1|  putative ABC transport system,...   250   8e-65
 gi|111225333|ref|YP_716127.1|  putative amino acid transport...   249   9e-65


InterPro Summary:  InterProScan

InterPro
IPR000515
Family
Binding-protein-dependent transport systems inner membrane component
PF00528 [26-246]T 3.6e-23 PF00528 BPD_transp_1 BPD_transp_1
PS50928 [30-237]T 18.182 PS50928 ABC_TM1 ABC_TM1
InterPro
IPR002197
Domain
Helix-turn-helix, Fis-type
PR01590 [134-151]T 86 PR01590 HTHFIS[151-171]T 86 PR01590 HTHFIS HTHFIS
InterPro
IPR010065
Domain
Amino acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine
TIGR01726 [25-138]T 6.9e-15 TIGR01726 HEQRo_perm_3TM: amino acid ABC transporter, HEQRo_perm_3TM: amino acid ABC transporter,
noIPR
unintegrated
unintegrated
signalp [1-48]? NA signalp signal-peptide signal-peptide
tmhmm [29-49]? NA tmhmm transmembrane_regions[70-92]? NA tmhmm transmembrane_regions[111-131]? NA tmhmm transmembrane_regions[188-208]? NA tmhmm transmembrane_regions[214-236]? NA tmhmm transmembrane_regions transmembrane_regions


COGS Summary:  COGS Search
BeTs to 15 clades of COG0765
COG name: ABC-type amino acid transport system, permease component
Functional Class: E [Metabolism--Amino acid transport and metabolism]
The phylogenetic pattern of COG0765 is a----z--vd-lbcefgh-nujxi--
Number of proteins in this genome belonging to this COG is 3
Blocks Summary:  Blocks Search
No significant hits to the Blocks database.

 ProDom Summary:  Protein Domain Search
Residues 4-172 are 42% similar to a (TRANSMEMBRANE GLTJ) protein domain (PD995723 which is seen in Q8D312_WIGBR.

Residues 69-170 are 66% similar to a (TRANSMEMBRANE PERMEASE ABC TRANSPORTER TRANSPORTER SYSTEM MEMBRANE SUGAR COMPONENT AMINO) protein domain (PD015756 which is seen in Q9F3K6_STRCO.

Residues 124-242 are 57% similar to a (MEMBRANE SUPERFAMILY ABC GLUTAMATE/ASPARTATE TRANSMEMBRANE) protein domain (PDA10263 which is seen in Q6FAP0_ACIAD.

Residues 124-195 are 62% similar to a (ABC PERMEASE ACID AMINO TRANSPORTER) protein domain (PD965635 which is seen in Q8DK01_SYNEL.

Residues 145-242 are 53% similar to a (BLR1679 TRANSMEMBRANE) protein domain (PD758531 which is seen in Q89TU6_BRAJA.

Residues 171-214 are 84% similar to a (TRANSMEMBRANE PERMEASE ABC AMINO ACID TRANSPORTER TRANSPORTER SYSTEM MEMBRANE GLUTAMINE) protein domain (PD857674 which is seen in Q8G543_BIFLO.

Residues 171-213 are 86% similar to a (TRANSPORTER COMPONENT ABC-TYPE PERMEASE) protein domain (PD955138 which is seen in Q6AA60_PROAC.


Paralogs:  Local Blast Search


Pfam Summary:  Pfam Search
Residues 26 to 246 (E_value = 3.9e-23) place ANA_0908 in the BPD_transp_1 family which is described as Binding-protein-dependent transport system inner membrane component.


 Structural Feature(s):
Feature Type  Start  Stop
Transmembrane  
33  
49
Transmembrane  
110  
126
Transmembrane  
219  
235

Top PDB Hits:
No significant hits to the PDB database (E-value < E-10).

Gene Protein Sequence:
MLIHGLVTNEKFHWSTVWFFLREVHVVKAVGWTLLLTFMAMAIGIVLAVT
TAILRQSSNPVLRWVALAYLWFFRGTPIYTQLVFWGALSALYQKLSLGIP
FGPELLTFKTTTVFTPFVAAVLGLGINEGAYLSEIVRSGLNSVDKGQSEA
AGALGMSRGQILRRIVLPQAMRVIVPPTGNETISMLKTTSLVLAVPFTLD
LTFVTNSYASLTYQIIPLLLVAAIWYIIITSILMVGQHYIERYYGKGFDS
DKSSGSSGRGLSARQQAILNAHTTKDDPFLEVTP$

Gene Nucleotide Sequence:  Sequence Viewer
ATGCTCATCCACGGGCTGGTCACCAATGAGAAGTTCCACTGGTCCACGGT
CTGGTTCTTCCTGCGTGAGGTCCACGTGGTCAAGGCCGTCGGCTGGACGC
TGCTGCTGACCTTCATGGCGATGGCCATCGGCATCGTGCTGGCGGTCACC
ACGGCGATCCTGCGCCAATCCTCCAACCCGGTCCTGCGCTGGGTGGCACT
GGCCTACCTGTGGTTCTTCCGCGGCACCCCGATCTACACCCAGCTGGTCT
TCTGGGGGGCGCTGTCCGCGCTCTACCAGAAGCTGAGTCTGGGAATCCCC
TTCGGCCCCGAGCTGCTGACCTTCAAGACGACGACGGTCTTCACCCCCTT
CGTCGCGGCGGTCCTGGGGCTGGGCATCAACGAGGGCGCCTATCTGTCCG
AGATCGTCCGCTCGGGCCTGAACTCGGTGGACAAGGGCCAGAGCGAGGCC
GCCGGAGCCCTGGGCATGAGCAGGGGCCAGATCCTGCGCAGGATCGTCCT
GCCCCAGGCGATGAGGGTCATCGTTCCGCCCACCGGCAACGAGACGATCT
CCATGCTCAAGACGACCTCCTTGGTCCTGGCGGTCCCCTTCACCCTGGAT
CTGACCTTCGTCACCAACTCCTACGCGTCGCTGACCTACCAGATCATTCC
GCTGCTTCTGGTCGCGGCCATCTGGTACATCATCATCACCTCGATCCTCA
TGGTGGGACAGCACTACATCGAACGCTATTACGGCAAGGGCTTCGACTCT
GACAAGTCCTCCGGCTCCTCGGGCCGGGGCCTGTCGGCCCGCCAGCAGGC
CATCCTCAATGCGCACACCACCAAGGACGATCCCTTCCTGGAGGTCACCC
CATGA

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