Bibliographic Citation
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Title | Prevention of 3-methylcholanthrene-induced fibrosarcomas in rats pre-inoculated with endogenous rat retrovirus |
Creator/Author | Fish, D.C. (Frederick Cancer Research Center, MD) ; Demarais, J.T. ; Djurickovic, D.B. ; Huebner, R.J. |
Publication Date | 1981 Apr 01 |
OSTI Identifier | OSTI ID: 6769083 |
Other Number(s) | CODEN: PNASA |
Resource Type | Journal Article |
Resource Relation | Proc. Natl. Acad. Sci. U.S.A. ; Vol/Issue: 78:4 |
Subject | 560305 -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987); ;3-METHYLCHOLANTHRENE-- TOXICITY;NEOPLASMS-- INHIBITION;VIRUSES-- INOCULATION; CARCINOGENESIS;IMMUNITY;RATS |
Related Subject | ANIMALS;AROMATICS;DISEASES;HYDROCARBONS;MAMMALS;MICROORGANISMS;ORGANIC COMPOUNDS;PARASITES;PATHOGENESIS;POLYCYCLIC AROMATIC HYDROCARBONS;RODENTS;VERTEBRATES |
Description/Abstract | Weanling Fischer 344 rats received a single intraperitoneal injection of a 1000-fold concentrated preparation of endogenous nontransforming rat retrovirus.^Ten days later, the rats were each given a single subcutaneous injection of 3-methylcholanthrene.^The rats inoculated with the endogenous rat retrovirus were significantly protected against the development of cancer, whereas uninoculated rats and rats given one of several murine tetroviruses or baboon retrovirus were not protected. |
Country of Publication | United States |
Language | English |
Format | Pages: 2526-2527 |
System Entry Date | 2001 May 13 |
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