Animal Production Program
01C55 |
C57BL/6N
(C Black 6, C57 Black subline 6, B6) |
|
Origin: |
To N 1951 from Jax at F32. See C57BL/KaLwN; strains 6 and 10 separated
prior to 1937. To Jax in 1948 from Hall. |
Genetics: |
a, B, C
Intense black
Genes:
Car-2a, Ce-2a, Cs-1g, Es-1a, Es-3a, Es-10a, Gpd-1a, Gpi-1b, Gusb, Hbaa, Hbbs,
Idh-1a, Lvb, Mod-1b, Mup-1b, Pep-3a, Pgm-1a, Trfb
Hc1, H-2Db, H-2Kb, Lyb-2b, Lyt-1b, Lyt-2b, Lyt-3b, Thy-1b, Tlab.
|
|
|
Diseases |
Neoplastic (Spontaneous): |
|
- Very low incidence of mammary tumors. (274)
|
|
|
Neoplastic (Induced): |
|
- More than 75% developed pulmonary metastases within 50 days
of amputation of legs with autochthonous 3-methylcholanthrene-induced
sarcomas providing a useful model for studies of metastases and
evaluation of cancer therapy in a minimal residual disease setting.
(790)
- N-butylnitrosourea induced leukemia in 91% of C57BL/6J mice;
thymic lymphoblastic, 0-alloantigen-positive (T cell) leukemia
predominated with a few cases of non-thymic
or stem cell leukemia. Thymectomy reduced the incidence to 64%. (659)
- 3-Methylcholanthrene induced brain tumors in 60% of males.
(404)
- Dietary acetylaminofluorene or chlordane induced elevated
0-fetoprotein levels and malignant hepatic lesions. (049)
- In comparison with other inbred strains, C57BL/6 is resistant
to Gross, Tennant, and Friend B viruses. (370)
|
|
|
Non-Neoplastic (Spontaneous): |
|
- No dystrophic cardiac calcinosis detected in either sex. (160)
- Intestinal volvulus in a small percentage. (140)
|
|
|
Non-Neoplastic (Induced): |
|
- Incidence of cortisone-induced cleft palate much higher on one
commercial diet than on another. (464)
- Relatively resistant to ectromelia. (632)
- Susceptible to infection with Leishmania tropica, but no clinical
signs of disease. (063)
- Benzo(a)pyrene administration at day 7 or 10 of gestation caused
in utero toxicity and teratogenicity more in C57BL/6 thant in Akr
mice. Allelic differences at
the Ah locus in the fetus were correlated with dysmorphogenesis. (664)
|
|
|
Other Characteristics |
Immunologic: |
|
- BCG pretreatment accelerated the recovery of granuloctye
counts after cyclophosphamide-induced leukopenia. (386)
- Delayed hypersensitivity to methylated serum albumin was enhanced
by cycloposphamide in young, but not old mice. (469)
- High interferon production after induction with Newcastle
disease virus or mammary tumor virus. (131)
- Responsive to pertussis HSF. (778,500)
- Two Lyt differentiated thymocyte populations were detected:
one with Lyt-1+ and one with Lyt 123+. (445)
|
|
|
Biochemical: |
|
- Aryl hydrocarbon hydroxylase is inducible by 3-methylcholanthrene
and other polycyclic hydrocarbons. The “responsive” Ahb allele is present. (404,403)
- Morphine increased 3-methoxytyramine and cyclic AMP levels in
striatum. (561)
- Liver alcohol dehydrogenase and aldehyde dehydrogenase activities
30% and 300% greater, respectively, than those of DBA/2. (299)
|
|
Behavioral: |
|
- High preference for alcohol and for morphine presented in a
saccharin vehicle. (794)
|
|
Misc: |
|
- Survival time ws significantly shortened by the intraperitoneal,
but not oral administration of benzo(a)pyrene. (737)
- 3-Methylcholanthrene was more toxic to C57BL/6N primordial oocytes
than to DBA/2N oocytes. (447)
- Resistant to audiogenic seizures at all ages, but susceptibility
enhanced by treatment with excess thyroxine. (647,646)
- Less sensitive to analgesic action of morphine than DBA/2 and
locomotor response is higher. (561)
- Resistant to toxic effects of chloroform. (127,097)
|
|
|
|
|