Bibliographic Citation
| Document | For copies of Journal Articles, please contact the Publisher or your local public or university library and refer to the information in the Resource Relation field. For copies of other documents, please see the Availability, Publisher, Research Organization, Resource Relation and/or Author (affiliation information) fields and/or Document Availability. |
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| Title | Mesothelioma relative to asbestos, radiation, and methylcholanthrene |
| Creator/Author | Warren, S. ; Brown, C.E. ; Chute, R.N. ; Federman, M. |
| Publication Date | 1981 Jun 01 |
| OSTI Identifier | OSTI ID: 5634869 |
| Other Number(s) | CODEN: APLMA |
| Resource Type | Journal Article |
| Resource Relation | Arch. Pathol. Lab. Med. ; Vol/Issue: 105:6 |
| Subject | 560306 -- Chemicals Metabolism & Toxicology-- Man-- (-1987) ;560152 -- Radiation Effects on Animals-- Animals ;550900 -- Pathology; ;ASBESTOS-- RADIOSENSITIVITY EFFECTS;ASBESTOS-- TOXICITY;LUNGS-- SENSITIVITY;PLEURA-- SENSITIVITY; CHOLANTHRENE;NEOPLASMS;PATHOLOGY;RADIATION DOSES;RATS;WHOLE-BODY IRRADIATION |
| Related Subject | ANIMALS;AROMATICS;BODY;CONDENSED AROMATICS;DISEASES;DOSES;EXTERNAL IRRADIATION;IRRADIATION;MAMMALS;MEMBRANES;ORGANIC COMPOUNDS;ORGANS;RESPIRATORY SYSTEM;RODENTS;SEROUS MEMBRANES;VERTEBRATES |
| Description/Abstract | The carcinogenicity of chrysotile asbestos fibers (Canadian and Rhodesian) for the mesothelium of pleura and peritoneum of NEDH rats was explored by injection of 2 mg of asbestos fibers suspended in saline intratracheally, intrapleurally, or intraperitoneally, with or without ancillary radiation treatment (1,000 rad to the whole body of parabiont rats or 2,000 rad to the right thorax of single rats), or alternatively, by injection of asbestos plus 1 mg of 3-methylcholanthrene.^A highly significant incidence of mesothelioma (3.8%) was noted in 159 rats treated with asbestos alone, as compared with 0.1% in 1,417 control rats.^Additional treatment with radiation or 3-methylcholanthrene increased this incidence to 11.8% and 25.5%, respectively, the latter increase alone being significant at the .01 level of probability. |
| Country of Publication | United States |
| Language | English |
| Format | Pages: 305-312 |
| System Entry Date | 2001 May 13 |
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