BLASTP 2.2.17 [Aug-26-2007]
Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Reference for composition-based statistics:
Schäffer, Alejandro A., L. Aravind, Thomas L. Madden,
Schaffer, Alejandro A., L. Aravind, Thomas L. Madden,
Sergei Shavirin, John L. Spouge, Yuri I. Wolf,
Eugene V. Koonin, and Stephen F. Altschul (2001),
"Improving the accuracy of PSI-BLAST protein database searches with
composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005.
Query= AA00954
(248 letters)
Database: nr
5,470,121 sequences; 1,894,087,724 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|15603678|ref|NP_246752.1| HemX [Pasteurella multocida su... 343 6e-93
gi|52424330|ref|YP_087467.1| HemD protein [Mannheimia succi... 320 7e-86
gi|152978039|ref|YP_001343668.1| Uroporphyrinogen III synth... 318 1e-85
gi|32029941|ref|ZP_00132885.1| COG1587: Uroporphyrinogen-II... 298 3e-79
gi|113460194|ref|YP_718251.1| uroporphyrinogen-III synthase... 264 3e-69
gi|32033975|ref|ZP_00134231.1| COG1587: Uroporphyrinogen-II... 261 2e-68
gi|153091049|gb|EDN73054.1| uroporphyrinogen-III synthase [... 259 1e-67
gi|85060345|ref|YP_456047.1| uroporphyrinogen III synthase ... 204 4e-51
gi|77959977|ref|ZP_00823884.1| COG1587: Uroporphyrinogen-II... 202 1e-50
gi|77978549|ref|ZP_00833977.1| COG1587: Uroporphyrinogen-II... 201 4e-50
gi|123440581|ref|YP_001004575.1| uroporphyrinogen-III synth... 199 2e-49
gi|37528462|ref|NP_931807.1| uroporphyrinogen-III synthetas... 198 2e-49
gi|77973624|ref|ZP_00829170.1| COG1587: Uroporphyrinogen-II... 198 3e-49
gi|118067368|ref|ZP_01535625.1| Uroporphyrinogen III syntha... 196 8e-49
gi|157081637|gb|ABV11315.1| hypothetical protein CKO_00146 ... 194 3e-48
gi|50123109|ref|YP_052276.1| uroporphyrinogen-III synthetas... 193 1e-47
gi|77957820|ref|ZP_00821866.1| COG1587: Uroporphyrinogen-II... 192 1e-47
gi|146313620|ref|YP_001178694.1| Uroporphyrinogen-III synth... 189 2e-46
gi|16762197|ref|NP_457814.1| uroporphyrinogen-III synthetas... 188 2e-46
gi|56415792|ref|YP_152867.1| uroporphyrinogen-III synthetas... 188 2e-46
gi|16767208|ref|NP_462823.1| uroporphyrinogen-III synthetas... 188 3e-46
gi|62182408|ref|YP_218825.1| uroporphyrinogen-III synthetas... 187 4e-46
gi|156935871|ref|YP_001439787.1| hypothetical protein ESA_0... 187 4e-46
gi|94676811|ref|YP_588540.1| uroporphyrinogen-III synthase ... 186 8e-46
gi|71892350|ref|YP_278084.1| uroporphyrinogen-III synthetas... 185 2e-45
gi|152972792|ref|YP_001337938.1| uroporphyrinogen-III synth... 184 5e-45
gi|15804392|ref|NP_290432.1| uroporphyrinogen-III synthetas... 182 1e-44
gi|75236887|ref|ZP_00720956.1| COG1587: Uroporphyrinogen-II... 182 1e-44
gi|83585947|ref|ZP_00924586.1| COG1587: Uroporphyrinogen-II... 182 2e-44
gi|51594539|ref|YP_068730.1| uroporphyrinogen-III synthetas... 182 2e-44
gi|26250542|ref|NP_756582.1| uroporphyrinogen-III synthetas... 182 2e-44
gi|82779018|ref|YP_405367.1| uroporphyrinogen III synthase ... 182 2e-44
gi|16123985|ref|NP_407298.1| uroporphyrinogen-III synthetas... 181 3e-44
gi|82546155|ref|YP_410102.1| uroporphyrinogen III synthase ... 180 5e-44
gi|75188546|ref|ZP_00701813.1| COG1587: Uroporphyrinogen-II... 180 6e-44
gi|75512637|ref|ZP_00735149.1| COG1587: Uroporphyrinogen-II... 180 6e-44
gi|16131656|ref|NP_418248.1| uroporphyrinogen III synthase ... 180 8e-44
gi|146336|gb|AAA23956.1| uroporphyrinogen-III cosynthetase ... 180 8e-44
gi|74314315|ref|YP_312734.1| uroporphyrinogen III synthase ... 179 1e-43
gi|24115096|ref|NP_709606.1| uroporphyrinogen-III synthetas... 179 1e-43
gi|89104221|ref|ZP_01176771.1| COG1587: Uroporphyrinogen-II... 179 1e-43
gi|75177764|ref|ZP_00697829.1| COG1587: Uroporphyrinogen-II... 179 1e-43
gi|41676|emb|CAA68776.1| unnamed protein product [Escherich... 178 3e-43
gi|33520024|ref|NP_878856.1| uroporphyrinogen-III synthetas... 171 3e-41
gi|33152756|ref|NP_874109.1| possible uroporphyrinogen III ... 170 8e-41
gi|32490990|ref|NP_871244.1| hypothetical protein WGLp241 [... 163 9e-39
gi|37678264|ref|NP_932873.1| uroporphyrinogen-III synthetas... 159 2e-37
gi|27364542|ref|NP_760070.1| uroporphyrinogen-III synthetas... 159 2e-37
gi|59710672|ref|YP_203448.1| uroporphyrinogen-III synthase ... 157 7e-37
gi|86148166|ref|ZP_01066464.1| uroporphyrinogen-III synthet... 153 7e-36
gi|84393565|ref|ZP_00992319.1| uroporphyrinogen-III synthet... 153 1e-35
gi|90414240|ref|ZP_01222220.1| hypothetical uroporphyrinoge... 152 2e-35
gi|148978778|ref|ZP_01815158.1| uroporphyrinogen-III synthe... 152 2e-35
gi|54310582|ref|YP_131602.1| hypothetical uroporphyrinogen ... 150 8e-35
gi|28899763|ref|NP_799368.1| uroporphyrinogen-III synthetas... 148 4e-34
gi|90581041|ref|ZP_01236841.1| hypothetical uroporphyrinoge... 145 2e-33
gi|2495182|sp|Q59683|HEM4_PROMI Uroporphyrinogen-III syntha... 144 3e-33
gi|116184836|ref|ZP_01474760.1| hypothetical protein VEx2w_... 144 6e-33
gi|150422138|gb|EDN14104.1| uroporphyrinogen-III synthase [... 143 1e-32
gi|153803405|ref|ZP_01957991.1| uroporphyrinogen-III syntha... 143 1e-32
gi|125620869|gb|EAZ49222.1| uroporphyrinogen-III synthase [... 142 1e-32
gi|153826275|ref|ZP_01978942.1| uroporphyrinogen-III syntha... 142 2e-32
gi|89074444|ref|ZP_01160921.1| hypothetical uroporphyrinoge... 142 2e-32
gi|116188281|ref|ZP_01478061.1| hypothetical protein VchoM_... 142 2e-32
gi|15640151|ref|NP_229778.1| uroporphyrinogen-III synthetas... 142 2e-32
gi|153214847|ref|ZP_01949655.1| uroporphyrinogen-III syntha... 142 2e-32
gi|91227535|ref|ZP_01261872.1| uroporphyrinogen-III synthet... 142 2e-32
gi|153835502|ref|ZP_01988169.1| uroporphyrinogen-III syntha... 141 3e-32
gi|156972663|ref|YP_001443570.1| hypothetical protein VIBHA... 141 3e-32
gi|116215617|ref|ZP_01481589.1| hypothetical protein VchoR_... 140 5e-32
gi|149908496|ref|ZP_01897158.1| hypothetical uroporphyrinog... 134 4e-30
gi|149191475|ref|ZP_01869724.1| uroporphyrinogen-III synthe... 134 7e-30
gi|114561626|ref|YP_749139.1| Uroporphyrinogen III synthase... 133 1e-29
gi|145300737|ref|YP_001143578.1| uroporphyrinogen-III synth... 133 1e-29
gi|120600513|ref|YP_965087.1| Uroporphyrinogen III synthase... 129 1e-28
gi|146294671|ref|YP_001185095.1| Uroporphyrinogen III synth... 129 1e-28
gi|124546386|ref|ZP_01705482.1| Uroporphyrinogen III syntha... 129 2e-28
gi|24375796|ref|NP_719839.1| uroporphyrinogen-III synthase ... 126 1e-27
gi|117619183|ref|YP_855001.1| uroporphyrinogen-III synthase... 126 1e-27
gi|153002482|ref|YP_001368163.1| Uroporphyrinogen III synth... 124 4e-27
gi|119947243|ref|YP_944923.1| Uroporphyrinogen III synthase... 120 7e-26
gi|91791754|ref|YP_561405.1| Uroporphyrinogen III synthase ... 120 8e-26
gi|118071325|ref|ZP_01539521.1| Uroporphyrinogen III syntha... 118 4e-25
gi|113968731|ref|YP_732524.1| Uroporphyrinogen III synthase... 117 5e-25
gi|114049126|ref|YP_739676.1| Uroporphyrinogen III synthase... 117 8e-25
gi|117918842|ref|YP_868034.1| Uroporphyrinogen III synthase... 116 1e-24
gi|119776387|ref|YP_929127.1| uroporphyrinogen-III synthase... 112 2e-23
gi|127511251|ref|YP_001092448.1| Uroporphyrinogen III synth... 111 5e-23
gi|118754283|ref|ZP_01602081.1| Uroporphyrinogen III syntha... 110 7e-23
gi|90416176|ref|ZP_01224108.1| uroporphyrinogen-III synthet... 109 2e-22
gi|53802805|ref|YP_115448.1| uroporphyrinogen-III synthase/... 109 2e-22
gi|149114245|ref|ZP_01840999.1| Uroporphyrinogen III syntha... 109 2e-22
gi|126176188|ref|YP_001052337.1| Uroporphyrinogen III synth... 108 3e-22
gi|94501431|ref|ZP_01307950.1| uroporphyrinogen-III synthet... 108 3e-22
gi|24209804|gb|AAN39862.1| HemD protein [Salmonella enteric... 108 3e-22
gi|24209828|gb|AAN39874.1| HemD protein [Salmonella enterit... 107 4e-22
gi|113947677|ref|ZP_01433342.1| Uroporphyrinogen III syntha... 107 5e-22
gi|56461659|ref|YP_156940.1| Uroporphyrinogen-III synthase ... 107 5e-22
gi|24209796|gb|AAN39858.1| HemD protein [Salmonella typhi] ... 107 6e-22
gi|88861268|ref|ZP_01135900.1| uroporphyrinogen-III synthas... 105 2e-21
gi|150378783|ref|ZP_01917980.1| Uroporphyrinogen III syntha... 103 1e-20
gi|71909285|ref|YP_286872.1| Uroporphyrinogen III synthase ... 103 1e-20
gi|114331037|ref|YP_747259.1| Uroporphyrinogen-III synthase... 102 2e-20
gi|88705503|ref|ZP_01103213.1| Uroporphyrinogen-III synthas... 102 2e-20
gi|82703802|ref|YP_413368.1| Uroporphyrinogen-III synthase ... 102 3e-20
gi|91774390|ref|YP_544146.1| Uroporphyrinogen-III synthase ... 100 1e-19
gi|71279895|ref|YP_266841.1| uroporphyrinogen-III synthase ... 100 1e-19
gi|87118401|ref|ZP_01074300.1| uroporphyrinogen-III synthet... 99 3e-19
gi|30248605|ref|NP_840675.1| Uroporphyrinogen III synthase ... 99 3e-19
gi|119897285|ref|YP_932498.1| HemD protein [Azoarcus sp. BH... 98 4e-19
gi|119475319|ref|ZP_01615672.1| Uroporphyrinogen-III syntha... 98 4e-19
gi|148244914|ref|YP_001219608.1| uroporphyrinogen-III synth... 98 6e-19
gi|118566870|gb|ABL01754.1| unknown [Salmonella enterica su... 96 2e-18
gi|67155437|ref|ZP_00417065.1| Uroporphyrinogen-III synthas... 96 2e-18
gi|85711586|ref|ZP_01042644.1| Uroporphyrinogen-III synthas... 96 3e-18
gi|90406696|ref|ZP_01214889.1| uroporphyrinogen-III synthas... 95 3e-18
gi|89093769|ref|ZP_01166715.1| uroporphyrinogen-III synthet... 95 4e-18
gi|152997594|ref|YP_001342429.1| Uroporphyrinogen III synth... 94 5e-18
gi|121997817|ref|YP_001002604.1| Uroporphyrinogen III synth... 93 2e-17
gi|152989208|ref|YP_001351321.1| uroporphyrinogen-III synth... 92 2e-17
gi|91782421|ref|YP_557627.1| Uroporphyrinogen III synthase ... 91 6e-17
gi|104784254|ref|YP_610752.1| uroporphyrinogen III synthase... 91 6e-17
gi|146305322|ref|YP_001185787.1| Uroporphyrinogen III synth... 91 7e-17
gi|110835182|ref|YP_694041.1| uroporphyrinogen-III synthase... 90 1e-16
gi|34495507|ref|NP_899722.1| uroporphyrinogen-III synthetas... 89 2e-16
gi|83749207|ref|ZP_00946209.1| UROPORPHYRINOGEN-III SYNTHAS... 89 2e-16
gi|56476046|ref|YP_157635.1| uroporphyrinogen III synthase ... 89 2e-16
gi|15600452|ref|NP_253946.1| uroporphyrinogen-III synthetas... 88 5e-16
gi|109896671|ref|YP_659926.1| Uroporphyrinogen III synthase... 88 5e-16
gi|496215|gb|AAA18908.1| uropprphyrinogen-III-synthase [Pse... 88 5e-16
gi|49082228|gb|AAT50514.1| PA5259 [synthetic construct] 88 5e-16
gi|84317871|ref|ZP_00966306.1| COG1587: Uroporphyrinogen-II... 88 6e-16
gi|119503706|ref|ZP_01625788.1| hypothetical protein MGP208... 87 9e-16
gi|52842940|ref|YP_096739.1| uroporphyrinogen III methylase... 86 2e-15
gi|118032435|ref|ZP_01503884.1| protein of unknown function... 86 3e-15
gi|54298728|ref|YP_125097.1| Uroporphyrinogen-III synthetas... 85 3e-15
gi|118602826|ref|YP_904041.1| Uroporphyrinogen III synthase... 85 3e-15
gi|17547075|ref|NP_520477.1| uroporphyrinogen-III synthetas... 85 3e-15
gi|70733285|ref|YP_263059.1| uroporphyrinogen-III synthetas... 85 4e-15
gi|77164031|ref|YP_342556.1| Uroporphyrinogen III synthase ... 85 4e-15
gi|153872668|ref|ZP_02001493.1| Uroporphyrinogen III syntha... 85 4e-15
gi|121528531|ref|ZP_01661145.1| putative bifunctional: urop... 85 5e-15
gi|118038275|ref|ZP_01509679.1| protein of unknown function... 84 5e-15
gi|114771936|ref|ZP_01449325.1| uroporphyrinogen-III syntha... 84 5e-15
gi|54295574|ref|YP_127989.1| Uroporphyrinogen-III synthetas... 84 6e-15
gi|120553423|ref|YP_957774.1| Uroporphyrinogen III synthase... 84 6e-15
gi|148358524|ref|YP_001249731.1| uroporphyrinogen III methy... 83 1e-14
gi|74318585|ref|YP_316325.1| uroporphyrinogen-III synthase ... 83 1e-14
gi|99910313|ref|ZP_01317340.1| hypothetical protein Bpse1_0... 83 2e-14
gi|53718658|ref|YP_107644.1| uroporphyrinogen-III synthetas... 82 2e-14
gi|100236282|ref|ZP_01336899.1| hypothetical protein Bpse4_... 82 2e-14
gi|82536537|ref|ZP_00895542.1| hypothetical protein Bpse110... 82 2e-14
gi|149376991|ref|ZP_01894745.1| Uroporphyrinogen-III syntha... 82 3e-14
gi|153888974|ref|ZP_02010109.1| protein of unknown function... 82 4e-14
gi|77461707|ref|YP_351214.1| Uroporphyrinogen III synthase ... 81 5e-14
gi|83720469|ref|YP_441429.1| uroporphyrinogen-III synthase ... 81 7e-14
gi|100123077|ref|ZP_01328783.1| hypothetical protein BpseS_... 80 7e-14
gi|100063476|ref|ZP_01325007.1| hypothetical protein BpseP_... 80 8e-14
gi|76811096|ref|YP_332642.1| uroporphyrinogen-III synthetas... 80 8e-14
gi|53725179|ref|YP_102500.1| uroporphyrinogen-III synthetas... 80 8e-14
gi|126666606|ref|ZP_01737584.1| Uroporphyrinogen-III syntha... 78 4e-13
gi|146280920|ref|YP_001171073.1| uroporphyrinogen-III synth... 78 4e-13
gi|92115223|ref|YP_575151.1| Uroporphyrinogen III synthase ... 78 5e-13
gi|28867369|ref|NP_789988.1| uroporphyrinogen-III synthetas... 77 7e-13
gi|77359076|ref|YP_338651.1| uroporphyrinogen-III synthase ... 77 8e-13
gi|118696766|ref|ZP_01554847.1| protein of unknown function... 77 1e-12
gi|121591884|ref|ZP_01679048.1| uroporphyrinogen-III synthe... 76 2e-12
gi|148545466|ref|YP_001265568.1| Uroporphyrinogen-III synth... 75 3e-12
gi|115352518|ref|YP_774357.1| protein of unknown function D... 75 3e-12
gi|26986931|ref|NP_742356.1| uroporphyrinogen-III synthetas... 75 3e-12
gi|114321816|ref|YP_743499.1| Uroporphyrinogen III synthase... 75 3e-12
gi|121634572|ref|YP_974817.1| hypothetical protein NMC0730 ... 74 6e-12
gi|2580594|gb|AAD13643.1| Gly1ORF2 [Neisseria gonorrhoeae] 74 7e-12
gi|59800803|ref|YP_207515.1| uroporphyrinogen-III synthetas... 74 7e-12
gi|153206966|ref|ZP_01945784.1| uroporphyrinogen-III syntha... 74 9e-12
gi|29655355|ref|NP_821047.1| uroporphyrinogen-III synthase ... 74 1e-11
gi|126359093|ref|ZP_01716089.1| Uroporphyrinogen-III syntha... 73 1e-11
gi|83643193|ref|YP_431628.1| Uroporphyrinogen-III synthase ... 73 1e-11
gi|119469645|ref|ZP_01612514.1| uroporphyrinogen-III syntha... 72 2e-11
gi|95927860|ref|ZP_01310613.1| hypothetical protein CburR_0... 72 4e-11
gi|94494188|ref|ZP_01301391.1| hypothetical protein Rgryl_0... 72 4e-11
gi|88812445|ref|ZP_01127694.1| uroporphyrinogen III synthas... 71 5e-11
gi|94311680|ref|YP_584890.1| protein of unknown function DU... 71 6e-11
gi|15793945|ref|NP_283767.1| uroporphyrinogen-III synthetas... 71 7e-11
gi|71737073|ref|YP_272378.1| uroporphyrinogen-III synthetas... 70 8e-11
gi|119856254|ref|ZP_01637687.1| Uroporphyrinogen-III syntha... 70 9e-11
gi|66043332|ref|YP_233173.1| uroporphyrinogen-III synthetas... 70 1e-10
gi|134296606|ref|YP_001120341.1| protein of unknown functio... 70 1e-10
gi|118594155|ref|ZP_01551502.1| uroporphyrinogen III methyl... 69 2e-10
gi|73540407|ref|YP_294927.1| uroporphyrinogen-III synthetas... 69 2e-10
gi|152981768|ref|YP_001352833.1| uroporphyrinogen-III synth... 68 4e-10
gi|145588842|ref|YP_001155439.1| Uroporphyrinogen III synth... 68 6e-10
gi|78484458|ref|YP_390383.1| uroporphyrinogen III methylase... 68 6e-10
gi|78067220|ref|YP_369989.1| uroporphyrinogen-III synthetas... 67 8e-10
gi|115423375|emb|CAJ49909.1| uroporphyrinogen-III synthase ... 67 1e-09
gi|119876160|ref|ZP_01643211.1| Uroporphyrinogen III syntha... 66 2e-09
gi|15676675|ref|NP_273819.1| uroporphyrinogen-III synthetas... 64 6e-09
gi|118719131|ref|ZP_01571662.1| protein of unknown function... 63 1e-08
gi|51245586|ref|YP_065470.1| uroporphyrinogen III synthase/... 62 3e-08
gi|84355413|ref|ZP_00980297.1| COG2959: Uncharacterized enz... 61 8e-08
gi|107023361|ref|YP_621688.1| protein of unknown function D... 60 8e-08
gi|84362557|ref|ZP_00987176.1| COG2959: Uncharacterized enz... 60 1e-07
gi|50083561|ref|YP_045071.1| uroporphyrinogen-III synthase ... 59 2e-07
gi|134094242|ref|YP_001099317.1| uroporphyrinogen III synth... 59 3e-07
gi|118707285|ref|ZP_01559871.1| protein of unknown function... 59 4e-07
gi|116750622|ref|YP_847309.1| uroporphyrin-III C-methyltran... 57 1e-06
gi|118444865|ref|YP_878762.1| uroporphyrinogen III synthase... 57 1e-06
gi|28198963|ref|NP_779277.1| uroporphyrinogen-III synthetas... 57 1e-06
gi|15838399|ref|NP_299087.1| uroporphyrinogen-III synthetas... 55 3e-06
gi|111019044|ref|YP_702016.1| probable uroporphiryn-III C-m... 55 4e-06
gi|120401861|ref|YP_951690.1| Uroporphyrinogen III synthase... 55 4e-06
gi|71898564|ref|ZP_00680735.1| Uroporphyrinogen III synthas... 55 4e-06
gi|116622287|ref|YP_824443.1| uroporphyrin-III C-methyltran... 55 5e-06
gi|88792783|ref|ZP_01108501.1| uroporphyrinogen-III synthet... 55 5e-06
gi|71275392|ref|ZP_00651678.1| Uroporphyrinogen III synthas... 55 5e-06
gi|90023306|ref|YP_529133.1| Na+/H+ antiporter NhaA [Saccha... 54 6e-06
gi|108797658|ref|YP_637855.1| Uroporphyrinogen III synthase... 54 7e-06
gi|126433282|ref|YP_001068973.1| Uroporphyrinogen III synth... 54 7e-06
>gi|15603678|ref|NP_246752.1| HemX [Pasteurella multocida subsp. multocida str. Pm70]
gi|12722235|gb|AAK03897.1| HemX [Pasteurella multocida subsp. multocida str. Pm70]
Length = 248
Score = 343 bits (880), Expect = 6e-93, Method: Composition-based stats.
Identities = 168/245 (68%), Positives = 199/245 (81%)
Query: 1 MAVLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVS 60
MAVLVTRPD RG QL +ML +AG+ AIHLPLF IE+G ELN+LPNK ++LK GDYVFAVS
Sbjct: 1 MAVLVTRPDVRGAQLTEMLIQAGIFAIHLPLFTIETGRELNDLPNKLSQLKAGDYVFAVS 60
Query: 61 KSAVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNA 120
K AV +A TL TGF WR DL YF VGQ +A++F + E V YP QE+SEGLL L+A
Sbjct: 61 KHAVQYAVDTLKNTGFSWRTDLAYFAVGQRSAEFFASQIERAVLYPYRQESSEGLLALDA 120
Query: 121 MQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRAGIQ 180
MQDLS+K +LILRGNGGRE F+EQAQ RGA VE +ECY+R P YNNAEQ SICKRAGI
Sbjct: 121 MQDLSEKHILILRGNGGREYFSEQAQLRGAKVETLECYQRVPTAYNNAEQISICKRAGIN 180
Query: 181 TIVVTSAEILTQLVDFVPQNEHNWLKSCQLITVSERIAHLAEALGWQNVVISPRADNQTL 240
+V++SAEIL LVDFVP++EHNWLKSCQL+TVS+RIA+LA+ LGW +VV+SPRADN L
Sbjct: 181 RLVISSAEILQYLVDFVPESEHNWLKSCQLVTVSQRIANLAKQLGWCDVVVSPRADNVHL 240
Query: 241 LQTLL 245
L+TLL
Sbjct: 241 LKTLL 245
>gi|52424330|ref|YP_087467.1| HemD protein [Mannheimia succiniciproducens MBEL55E]
gi|52306382|gb|AAU36882.1| HemD protein [Mannheimia succiniciproducens MBEL55E]
Length = 249
Score = 320 bits (819), Expect = 7e-86, Method: Composition-based stats.
Identities = 151/237 (63%), Positives = 186/237 (78%)
Query: 1 MAVLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVS 60
MAVLVTRP E+G QLVDML K+GV A+HLP F I +G ELN+LPNKF +LK DYV AVS
Sbjct: 1 MAVLVTRPAEKGIQLVDMLNKSGVAALHLPFFNITAGRELNDLPNKFNQLKPNDYVVAVS 60
Query: 61 KSAVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNA 120
+SAVDFA +TL TGF WR DL YFTVGQ TA +F + +E PVHYP ENSEG+L L
Sbjct: 61 QSAVDFAAETLQNTGFHWRTDLQYFTVGQQTALHFASLSEQPVHYPFLSENSEGMLALAQ 120
Query: 121 MQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRAGIQ 180
MQ+L K VL+LRGN GRELF +Q RG +++I+ECY+R+PI Y+N EQTSICKRAGIQ
Sbjct: 121 MQNLKGKNVLLLRGNSGRELFPQQVLARGGDIDILECYQRQPIDYDNVEQTSICKRAGIQ 180
Query: 181 TIVVTSAEILTQLVDFVPQNEHNWLKSCQLITVSERIAHLAEALGWQNVVISPRADN 237
TIVVTS E+L L+ FVP+NE++WL+SCQL+ VS RI ++A GW ++V+SP+ADN
Sbjct: 181 TIVVTSGELLNTLIQFVPENEYDWLRSCQLVVVSTRIENMARKFGWTDIVVSPKADN 237
>gi|152978039|ref|YP_001343668.1| Uroporphyrinogen III synthase HEM4 [Actinobacillus succinogenes
130Z]
gi|150839762|gb|ABR73733.1| Uroporphyrinogen III synthase HEM4 [Actinobacillus succinogenes
130Z]
Length = 249
Score = 318 bits (816), Expect = 1e-85, Method: Composition-based stats.
Identities = 155/248 (62%), Positives = 190/248 (76%), Gaps = 2/248 (0%)
Query: 1 MAVLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVS 60
MAVLVTRPD RG+QL + L KAGV A+H+PLF I +G ELNELPNK +LK GDYVFAVS
Sbjct: 1 MAVLVTRPDSRGEQLTEALNKAGVAALHMPLFSISAGRELNELPNKMYQLKAGDYVFAVS 60
Query: 61 KSAVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNA 120
K+AV+FA +TL+ TGF WR DL YF VGQ +A+YF +E PVHYP ENSEGLL L
Sbjct: 61 KNAVEFAAETLSNTGFRWRQDLIYFAVGQSSAEYFCEQSEQPVHYPYGHENSEGLLALPQ 120
Query: 121 MQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRAGIQ 180
MQ L+DKTVLILRGNGGRELF QA +RGA VEI+ECYRR P+ Y+ +QT +C+RAGI
Sbjct: 121 MQRLTDKTVLILRGNGGRELFPAQAVRRGAQVEIIECYRRVPVEYDPKKQTDLCQRAGIN 180
Query: 181 TIVVTSAEILTQLVDFVPQNEHNWLKSCQLITVSERIAHLAEALGWQ--NVVISPRADNQ 238
TI+ TS+EILT+L +FVP E +WL C+L+T S R+A AE GWQ ++I+PRADN
Sbjct: 181 TIIATSSEILTRLTNFVPAEERDWLTQCRLVTASYRVAKSAERAGWQKRQILIAPRADNA 240
Query: 239 TLLQTLLQ 246
TL++ L +
Sbjct: 241 TLVKMLAE 248
>gi|32029941|ref|ZP_00132885.1| COG1587: Uroporphyrinogen-III synthase [Haemophilus somnus 2336]
Length = 246
Score = 298 bits (762), Expect = 3e-79, Method: Composition-based stats.
Identities = 145/246 (58%), Positives = 184/246 (74%)
Query: 1 MAVLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVS 60
MAVL+TRP ERG++LV+ML KAG++A+HLPL I +G ELN LP+K +L GDYV AVS
Sbjct: 1 MAVLITRPGERGERLVEMLNKAGIMALHLPLISIIAGQELNRLPDKLQQLNCGDYVVAVS 60
Query: 61 KSAVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNA 120
K+AV++A KTL+A GF WR DL+YFTVGQ TA+YF + E V+YP QE+SEGLL L
Sbjct: 61 KNAVEYAQKTLSAVGFCWRSDLYYFTVGQRTAEYFASQIENSVYYPVEQESSEGLLNLPQ 120
Query: 121 MQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRAGIQ 180
MQDL + +LILR NGGRE F EQA RGA VE +ECY+R PI YN E+ S+C+R G+
Sbjct: 121 MQDLQARNILILRANGGREFFTEQAILRGAKVETLECYQRMPIEYNKLEKISLCQRIGVD 180
Query: 181 TIVVTSAEILTQLVDFVPQNEHNWLKSCQLITVSERIAHLAEALGWQNVVISPRADNQTL 240
TIVVTS E+L LV VP NE WL SC+L+TVS+RIA A+++GW N+V++ +ADN +L
Sbjct: 181 TIVVTSQEMLNYLVKLVPTNETGWLFSCRLVTVSQRIAAFAKSVGWTNIVVADKADNLSL 240
Query: 241 LQTLLQ 246
L Q
Sbjct: 241 FLALQQ 246
>gi|113460194|ref|YP_718251.1| uroporphyrinogen-III synthase [Haemophilus somnus 129PT]
gi|112822237|gb|ABI24326.1| uroporphyrinogen-III synthase [Haemophilus somnus 129PT]
Length = 222
Score = 264 bits (675), Expect = 3e-69, Method: Composition-based stats.
Identities = 130/222 (58%), Positives = 163/222 (73%)
Query: 25 VAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVSKSAVDFAFKTLTATGFVWRHDLHY 84
+A+HLPL I +G ELN LPNK +L GDYV AVSK+AV++A KTL+A GF WR DL+Y
Sbjct: 1 MALHLPLISIIAGQELNRLPNKLQQLNCGDYVVAVSKNAVEYAQKTLSAVGFCWRSDLYY 60
Query: 85 FTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNAMQDLSDKTVLILRGNGGRELFAEQ 144
FTVGQ TA+YF + E V+YP QE+SEGLL L MQDL + +LILR NGGRE F EQ
Sbjct: 61 FTVGQRTAEYFASQIENSVYYPVEQESSEGLLNLPQMQDLQARNILILRANGGREFFTEQ 120
Query: 145 AQQRGANVEIVECYRREPIVYNNAEQTSICKRAGIQTIVVTSAEILTQLVDFVPQNEHNW 204
A RGA VE +ECY+R PI YN E+ S+C+R G+ TIVVTS E+L LV VP NE W
Sbjct: 121 AILRGAKVETLECYQRMPIEYNKLEKISLCQRIGVDTIVVTSQEMLNYLVKLVPTNETGW 180
Query: 205 LKSCQLITVSERIAHLAEALGWQNVVISPRADNQTLLQTLLQ 246
L SC+L+TVS+RIA LA+++GW N+V++ +ADN +L L Q
Sbjct: 181 LFSCRLVTVSQRIAALAKSVGWTNIVVADKADNLSLFLALQQ 222
>gi|32033975|ref|ZP_00134231.1| COG1587: Uroporphyrinogen-III synthase [Actinobacillus
pleuropneumoniae serovar 1 str. 4074]
gi|126208483|ref|YP_001053708.1| putative uroporphyrinogen-III synthase [Actinobacillus
pleuropneumoniae L20]
gi|126097275|gb|ABN74103.1| putative uroporphyrinogen-III synthase [Actinobacillus
pleuropneumoniae L20]
Length = 254
Score = 261 bits (668), Expect = 2e-68, Method: Composition-based stats.
Identities = 129/248 (52%), Positives = 174/248 (70%), Gaps = 2/248 (0%)
Query: 1 MAVLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVS 60
M VL+TRPD RGQ+LV+ML + + AIH PLF IE+G EL +LP+ ++L DYVFAVS
Sbjct: 1 MNVLITRPDYRGQELVEMLNQYQIFAIHQPLFTIEAGTELPQLPSVMSRLNTDDYVFAVS 60
Query: 61 KSAVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNA 120
K A+DFA +TL TGF +R DL YF VG+ +A YF+ T P +YP + ENSEGLL+L
Sbjct: 61 KHAIDFASETLVQTGFQYRSDLKYFAVGRQSAAYFSTKTAYPTYYPISSENSEGLLELPE 120
Query: 121 MQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRAGIQ 180
MQ L K +L+LR GR+ FAEQA RGANV+ +ECYRR+ + + E+ S+CKRAGI
Sbjct: 121 MQCLEGKNILVLRAEKGRDFFAEQASLRGANVQYLECYRRQYLADSITEKMSLCKRAGID 180
Query: 181 TIVVTSAEILTQLVDFVPQNEHNWLKSCQLITVSERIAHLAEALGW--QNVVISPRADNQ 238
+I+VTS +IL L + +++ WL C+LI VS RIA LA LGW V++S +ADN
Sbjct: 181 SIIVTSTDILITLYEQTAEDDRQWLIECRLIVVSTRIAQLAYKLGWSRNKVLLSEKADNN 240
Query: 239 TLLQTLLQ 246
+LL+++L+
Sbjct: 241 SLLESVLK 248
>gi|153091049|gb|EDN73054.1| uroporphyrinogen-III synthase [Mannheimia haemolytica PHL213]
Length = 254
Score = 259 bits (661), Expect = 1e-67, Method: Composition-based stats.
Identities = 133/247 (53%), Positives = 170/247 (68%), Gaps = 2/247 (0%)
Query: 1 MAVLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVS 60
M VLVTR D RGQ+LVDML + + AIH PLF IE+G EL LP+ ++LK+ DYVF VS
Sbjct: 1 MNVLVTRLDSRGQELVDMLNEQQIFAIHQPLFTIEAGKELPLLPSAISRLKSDDYVFVVS 60
Query: 61 KSAVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNA 120
+AVD+A KTL TGF +R DL YF VGQ TA+Y T E V YP ENSEG+L L
Sbjct: 61 PNAVDYAAKTLVDTGFHFRSDLKYFAVGQRTAKYLTEKAEQAVIYPIEFENSEGVLALPE 120
Query: 121 MQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRAGIQ 180
MQ+L+DKT+LILR + GREL AE A RGA ++ +ECYRREP+ + E+ S+CKR G+
Sbjct: 121 MQNLTDKTILILRADSGRELLAETAVLRGATIQYLECYRREPVTDDIPEKISLCKRLGVD 180
Query: 181 TIVVTSAEILTQLVDFVPQNEHNWLKSCQLITVSERIAHLAEALGWQ--NVVISPRADNQ 238
TIV+TS+EIL L + + WL C L+ VS RIA +A+ +GWQ + +S +ADN
Sbjct: 181 TIVITSSEILRSLYEQAKADCRAWLFECDLVVVSRRIAKIAKQMGWQEDKIRVSDKADNV 240
Query: 239 TLLQTLL 245
TL+ TLL
Sbjct: 241 TLMNTLL 247
>gi|85060345|ref|YP_456047.1| uroporphyrinogen III synthase [Sodalis glossinidius str.
'morsitans']
gi|84780865|dbj|BAE75642.1| uroporphyrinogen III synthase [Sodalis glossinidius str.
'morsitans']
Length = 246
Score = 204 bits (519), Expect = 4e-51, Method: Composition-based stats.
Identities = 106/246 (43%), Positives = 142/246 (57%), Gaps = 1/246 (0%)
Query: 1 MAVLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVS 60
M++LVTRP G+QLV+ L G A HLPL G +L +L + A L GD +F VS
Sbjct: 1 MSILVTRPSPAGEQLVNRLRARGKSAWHLPLIEFTPGNDLPQLAQRLADLSAGDLLFIVS 60
Query: 61 KSAVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNA 120
+ A+++A LT G W L YF VG+ T +PV YP E SE LL+L A
Sbjct: 61 QHAINYAHPWLTQQGVTWPAGLQYFAVGRTTGLRLHGLCGLPVSYPDEGETSEDLLRLPA 120
Query: 121 MQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRAGIQ 180
+ + K LILRGNGGRE+ + +QRG + ECYRR PI YN EQ + I
Sbjct: 121 LARIEGKRALILRGNGGREVLEQTLRQRGVHTTYCECYRRSPIHYNGEEQGRRVQTLSID 180
Query: 181 TIVVTSAEILTQLVDFVPQ-NEHNWLKSCQLITVSERIAHLAEALGWQNVVISPRADNQT 239
T+V+TS E+L Q +P+ H WL C+LI +SER+A LA LGW ++V++ ADN
Sbjct: 181 TLVITSGEMLQQFYTLMPEYYRHAWLMHCRLIVISERLAILARQLGWTDIVVANAADNDA 240
Query: 240 LLQTLL 245
L++ LL
Sbjct: 241 LMRVLL 246
>gi|77959977|ref|ZP_00823884.1| COG1587: Uroporphyrinogen-III synthase [Yersinia mollaretii ATCC
43969]
Length = 251
Score = 202 bits (514), Expect = 1e-50, Method: Composition-based stats.
Identities = 103/249 (41%), Positives = 147/249 (59%), Gaps = 1/249 (0%)
Query: 1 MAVLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVS 60
M +LVTRP G+QLV L G VA H PL G +L +LP +++ GD VFA+S
Sbjct: 1 MTILVTRPSPSGEQLVSRLRALGRVAYHAPLIDFSPGDDLPKLPTLLQEMQAGDLVFALS 60
Query: 61 KSAVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNA 120
++AV +A L W L Y+ +G+GTA + + V +P E SE LL L
Sbjct: 61 QNAVRYANPLLKRNNLSWPAQLSYYAIGRGTALALHTASHLHVTFPPMGETSEMLLSLPD 120
Query: 121 MQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRAGIQ 180
+Q L+ K L+LRGNGGREL E QRGA V ECY+R PI Y+ +EQ++ +RAG+
Sbjct: 121 LQKLAGKKALLLRGNGGRELLGESLAQRGATVTFCECYQRSPIFYDGSEQSAHWQRAGVN 180
Query: 181 TIVVTSAEILTQLVDFVPQ-NEHNWLKSCQLITVSERIAHLAEALGWQNVVISPRADNQT 239
+VVTS E+L Q+ VP +WL C L+ VS+R+A LA +GW+++ ++ ADN
Sbjct: 181 ILVVTSGEMLQQIYTLVPDYYRSSWLLRCHLVVVSDRLAALAAQMGWRDIQVAENADNDA 240
Query: 240 LLQTLLQCR 248
L++ L + +
Sbjct: 241 LIRALQELK 249
>gi|77978549|ref|ZP_00833977.1| COG1587: Uroporphyrinogen-III synthase [Yersinia intermedia ATCC
29909]
Length = 249
Score = 201 bits (510), Expect = 4e-50, Method: Composition-based stats.
Identities = 104/245 (42%), Positives = 144/245 (58%), Gaps = 1/245 (0%)
Query: 1 MAVLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVS 60
M +LVTRP G+QLV L G VA H PL G +L +LP ++ GD VFA+S
Sbjct: 1 MTILVTRPSPAGEQLVSRLRALGRVAYHAPLIDFSPGYDLPKLPALLQDMQAGDLVFALS 60
Query: 61 KSAVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNA 120
++A+ +A L +W L Y+ +G+ TA + + V +P E SE LL L
Sbjct: 61 QNAIRYANPLLKRNNLLWPAQLSYYAIGRTTALALHTASRLHVTFPPMGETSEMLLSLPD 120
Query: 121 MQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRAGIQ 180
+Q LS K L+LRGNGGREL E QRGA V ECY+R PI Y+ +EQ++ +RAG+
Sbjct: 121 LQKLSGKKALLLRGNGGRELLGESLAQRGAIVTYCECYQRSPIFYDGSEQSAHWQRAGVD 180
Query: 181 TIVVTSAEILTQLVDFVPQ-NEHNWLKSCQLITVSERIAHLAEALGWQNVVISPRADNQT 239
+VVTS E+L Q+ VP +WL C+L+ VSER+A LA +GW N+ ++ ADN
Sbjct: 181 ILVVTSGEMLQQIYTLVPDYYRSSWLLRCRLVVVSERLATLAAQMGWSNIRVAENADNDA 240
Query: 240 LLQTL 244
L++ L
Sbjct: 241 LIRAL 245
>gi|123440581|ref|YP_001004575.1| uroporphyrinogen-III synthase [Yersinia enterocolitica subsp.
enterocolitica 8081]
gi|122087542|emb|CAL10323.1| uroporphyrinogen-III synthase [Yersinia enterocolitica subsp.
enterocolitica 8081]
Length = 248
Score = 199 bits (505), Expect = 2e-49, Method: Composition-based stats.
Identities = 101/245 (41%), Positives = 144/245 (58%), Gaps = 1/245 (0%)
Query: 1 MAVLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVS 60
M +LVTRP G+QLV L G VA H PL G +L +LP ++ GD VFA+S
Sbjct: 1 MTILVTRPSPAGEQLVSRLRALGRVAYHAPLIDFSPGDDLPKLPALLQDMQAGDLVFALS 60
Query: 61 KSAVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNA 120
++AV +A L W L Y+ +G+ TA + + V +P E SE LL L
Sbjct: 61 QNAVRYANPLLKRNNLSWPAQLSYYAIGRNTALALHTASRLHVTFPPTGETSEMLLSLPD 120
Query: 121 MQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRAGIQ 180
+Q L+ K L+LRGNGGREL E ++RGA V ECY+R PI Y+ +EQ++ +R+G+
Sbjct: 121 LQQLTGKKALLLRGNGGRELLGESLRERGATVTFCECYQRSPIFYDGSEQSAHWQRSGVD 180
Query: 181 TIVVTSAEILTQLVDFVPQ-NEHNWLKSCQLITVSERIAHLAEALGWQNVVISPRADNQT 239
+VVTS E+L Q+ VP +WL C+L+ VS+R+A LA +GW N+ ++ ADN
Sbjct: 181 ILVVTSGEMLQQIYTLVPDYYRSSWLLRCRLVVVSDRLAALAAQMGWSNIRVAENADNDA 240
Query: 240 LLQTL 244
L++ L
Sbjct: 241 LIRAL 245
>gi|37528462|ref|NP_931807.1| uroporphyrinogen-III synthetase [Photorhabdus luminescens subsp.
laumondii TTO1]
gi|36787900|emb|CAE17017.1| uroporphyrinogen-III synthase (UROS) (uroporphyrinogen-III
cosynthetase) (hydroxymethylbilane hydrolyase
[cyclizing]) [Photorhabdus luminescens subsp. laumondii
TTO1]
Length = 246
Score = 198 bits (504), Expect = 2e-49, Method: Composition-based stats.
Identities = 107/245 (43%), Positives = 148/245 (60%), Gaps = 1/245 (0%)
Query: 1 MAVLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVS 60
M++LVTRP G++LV L AG A PL I G+EL +L K L D VF +S
Sbjct: 1 MSILVTRPAPAGEELVRRLQAAGKTAFSAPLINIHPGSELPQLAEKLNPLNTRDMVFLLS 60
Query: 61 KSAVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNA 120
K+AV +A L W L Y+ +G+ TA F T M V + + E SE LL+L +
Sbjct: 61 KNAVYYANNQLNKINLSWPDKLIYYAIGRSTALAFHQLTGMNVIWSSEGETSEILLKLPS 120
Query: 121 MQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRAGIQ 180
+ + +K L+LRGNGGREL A +RGA V+ ECY R+P+ Y AE ++ ++ G+Q
Sbjct: 121 LHQVENKQALLLRGNGGRELIARTLTERGATVDYCECYFRQPVDYPAAEFSAHWQKYGVQ 180
Query: 181 TIVVTSAEILTQLVDFVPQNEHN-WLKSCQLITVSERIAHLAEALGWQNVVISPRADNQT 239
T+VVTS EIL L + +P+++ N WL C+LI VSER+AH A LGWQ+V ++ ADN
Sbjct: 181 TLVVTSGEILQLLYNLIPESDRNRWLLHCRLIVVSERLAHAARNLGWQDVKVAKSADNDA 240
Query: 240 LLQTL 244
L+Q L
Sbjct: 241 LIQAL 245
>gi|77973624|ref|ZP_00829170.1| COG1587: Uroporphyrinogen-III synthase [Yersinia frederiksenii ATCC
33641]
Length = 249
Score = 198 bits (503), Expect = 3e-49, Method: Composition-based stats.
Identities = 101/245 (41%), Positives = 144/245 (58%), Gaps = 1/245 (0%)
Query: 1 MAVLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVS 60
M +LVTRP G+QLV L G VA H PL G +L +LP +++ GD VFA+S
Sbjct: 1 MTILVTRPSPSGEQLVSRLRALGRVAYHAPLIDFSPGDDLPKLPALLQEMQAGDLVFALS 60
Query: 61 KSAVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNA 120
++A+ +A L W L Y+ +G+ TA + + V +P E SE LL L
Sbjct: 61 QNAIRYANPLLKRNNLSWPAQLSYYAIGRNTALALHTASRLHVTFPPTGETSEMLLSLPD 120
Query: 121 MQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRAGIQ 180
+Q LS K L+LRGNGGREL E +RGA V ECY+R PI Y+ +EQ++ +R+G+
Sbjct: 121 LQKLSGKKALLLRGNGGRELLGESLAERGATVTFCECYQRSPIFYDGSEQSAHWQRSGVD 180
Query: 181 TIVVTSAEILTQLVDFVPQ-NEHNWLKSCQLITVSERIAHLAEALGWQNVVISPRADNQT 239
+VVTS E+L Q+ VP +WL C+L+ VS+R+A LA +GW ++ I+ ADN
Sbjct: 181 ILVVTSGEMLQQIYTLVPDYYRSSWLLRCRLVVVSDRLAALAAQMGWSDIQIAENADNDA 240
Query: 240 LLQTL 244
L++ L
Sbjct: 241 LIRAL 245
>gi|118067368|ref|ZP_01535625.1| Uroporphyrinogen III synthase HEM4 [Serratia proteamaculans 568]
gi|118018494|gb|EAV32409.1| Uroporphyrinogen III synthase HEM4 [Serratia proteamaculans 568]
Length = 246
Score = 196 bits (499), Expect = 8e-49, Method: Composition-based stats.
Identities = 107/245 (43%), Positives = 146/245 (59%), Gaps = 1/245 (0%)
Query: 1 MAVLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVS 60
M +LVTRP G+QLV L G VA H PL G +L +LP +L +GD VF +S
Sbjct: 1 MTILVTRPSPSGEQLVSRLRALGRVAYHAPLIDFAPGGDLPKLPQALQQLNDGDLVFILS 60
Query: 61 KSAVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNA 120
+ +V +A + G W L Y+ +G+ TA + +PV YP QE SE LL L A
Sbjct: 61 QHSVSYANSVMGRVGLPWPARLAYYAIGRNTALAMHRISSLPVEYPREQEISETLLLLPA 120
Query: 121 MQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRAGIQ 180
+Q+L K LILRGNGGREL +RGA V ECY+R P+ Y+ +EQ++ +RAG+
Sbjct: 121 LQNLDGKQALILRGNGGRELLGNSLSERGAAVSYYECYQRSPVHYDGSEQSAHWQRAGVD 180
Query: 181 TIVVTSAEILTQLVDFVPQ-NEHNWLKSCQLITVSERIAHLAEALGWQNVVISPRADNQT 239
T+VVTS E+L QL VP +WL C+L+ VSER+A LA+ LGW + ++ ADN
Sbjct: 181 TLVVTSGEMLQQLYTLVPDYYRSSWLLRCRLVVVSERLATLAQELGWSTIRVADNADNDA 240
Query: 240 LLQTL 244
L++ L
Sbjct: 241 LIRAL 245
>gi|157081637|gb|ABV11315.1| hypothetical protein CKO_00146 [Citrobacter koseri ATCC BAA-895]
Length = 246
Score = 194 bits (494), Expect = 3e-48, Method: Composition-based stats.
Identities = 108/246 (43%), Positives = 142/246 (57%), Gaps = 3/246 (1%)
Query: 1 MAVLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVS 60
M++LVTRP G++LV L G VA PL G EL L ++ A L + D VFA+S
Sbjct: 1 MSILVTRPSPSGEELVSRLRTLGQVAWSFPLIEFTPGRELATLADRLAALTDNDLVFALS 60
Query: 61 KSAVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNA 120
+ AV FA L G W YF +G+ TA + + YP +E SE LLQL
Sbjct: 61 QHAVAFAHAQLQQQGLDWPVQPRYFAIGRTTALALHTVSGCDIRYPLDREISEVLLQLPE 120
Query: 121 MQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRAGIQ 180
+Q+++ K LILRGNGGREL + +RGA V ECY+R Y+ AE+ G+
Sbjct: 121 LQNIAGKRALILRGNGGRELLGKTLTERGAEVTFCECYQRSAKHYDGAEEAMRWHSRGVT 180
Query: 181 TIVVTSAEILTQLVDFVPQ--NEHNWLKSCQLITVSERIAHLAEALGWQNVVISPRADNQ 238
TIVVTS E+L QL +PQ EH WL C+L+ VSER+AHLA LGWQ++ ++ ADN
Sbjct: 181 TIVVTSGEMLQQLWSLIPQWYREH-WLLRCRLLVVSERLAHLARELGWQDIKVADNADND 239
Query: 239 TLLQTL 244
LL+ L
Sbjct: 240 ALLRAL 245
>gi|50123109|ref|YP_052276.1| uroporphyrinogen-III synthetase [Erwinia carotovora subsp.
atroseptica SCRI1043]
gi|49613635|emb|CAG77086.1| uroporphyrinogen-III synthase [Erwinia carotovora subsp.
atroseptica SCRI1043]
Length = 246
Score = 193 bits (490), Expect = 1e-47, Method: Composition-based stats.
Identities = 104/245 (42%), Positives = 141/245 (57%), Gaps = 1/245 (0%)
Query: 1 MAVLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVS 60
M +LVTRP G+QLV L K G A H PL G EL LP + L D VFA+S
Sbjct: 1 MTILVTRPSPTGEQLVTRLRKLGYHAWHSPLIEFSPGRELAGLPAQLHALHADDLVFALS 60
Query: 61 KSAVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNA 120
+ A+ +A L TG W L Y+ +G+ TA + PV YP +E SE LLQL
Sbjct: 61 QHAIHYADPMLARTGTSWPAHLAYYAIGRTTALALHKISAHPVTYPPERETSETLLQLPE 120
Query: 121 MQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRAGIQ 180
+QD++ K L+LRGNGGREL E +RGA V ECY+R + Y+ EQ+ ++ GI
Sbjct: 121 LQDVAGKRALLLRGNGGRELLGETLIERGAQVTYCECYQRRDVHYDGPEQSRHWQQIGID 180
Query: 181 TIVVTSAEILTQLVDFVPQ-NEHNWLKSCQLITVSERIAHLAEALGWQNVVISPRADNQT 239
+V+TS E+L ++ VP +WL CQLI VSER+A A LGW+++ ++ ADN
Sbjct: 181 KLVITSGEMLQRIYTLVPDYYRASWLLGCQLIVVSERLAEQARQLGWRDIRVADNADNDA 240
Query: 240 LLQTL 244
L++ L
Sbjct: 241 LVRAL 245
>gi|77957820|ref|ZP_00821866.1| COG1587: Uroporphyrinogen-III synthase [Yersinia bercovieri ATCC
43970]
Length = 251
Score = 192 bits (489), Expect = 1e-47, Method: Composition-based stats.
Identities = 104/245 (42%), Positives = 145/245 (59%), Gaps = 1/245 (0%)
Query: 1 MAVLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVS 60
M +LVTRP G+QLV L G VA H PL G +L +LP ++ GD VFA+S
Sbjct: 1 MTILVTRPSPSGEQLVSRLRALGRVAYHAPLIDFSPGDDLPKLPALLQNMQAGDLVFALS 60
Query: 61 KSAVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNA 120
++AV +A L +W L Y+ +G+GTA + + V +P E SE LL L
Sbjct: 61 QNAVRYANPLLKRNNLLWPAQLSYYAIGRGTALALHTASRLHVTFPPMGETSEMLLLLPD 120
Query: 121 MQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRAGIQ 180
+Q LS K L+LRGNGGREL E QRGA V ECY+R PI Y+ +EQ++ +RAG+
Sbjct: 121 LQKLSGKKALLLRGNGGRELLGESLAQRGAEVTFCECYQRSPIFYDGSEQSAHWQRAGVN 180
Query: 181 TIVVTSAEILTQLVDFVPQ-NEHNWLKSCQLITVSERIAHLAEALGWQNVVISPRADNQT 239
+VVTS E+L Q+ VP +WL C+L+ VS+R+A LA +GW ++ ++ ADN
Sbjct: 181 ILVVTSGEMLQQIYTLVPDYYRSSWLLRCRLVVVSDRLATLAAQMGWSDIRVAENADNDA 240
Query: 240 LLQTL 244
L++ L
Sbjct: 241 LIRAL 245
>gi|146313620|ref|YP_001178694.1| Uroporphyrinogen-III synthase [Enterobacter sp. 638]
gi|145320496|gb|ABP62643.1| Uroporphyrinogen-III synthase [Enterobacter sp. 638]
Length = 246
Score = 189 bits (479), Expect = 2e-46, Method: Composition-based stats.
Identities = 107/245 (43%), Positives = 139/245 (56%), Gaps = 1/245 (0%)
Query: 1 MAVLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVS 60
M +LVTRP G+QLV L G VA PL G EL+ L + L+ GD VFA+S
Sbjct: 1 MNILVTRPSPAGEQLVSRLRALGQVAWSFPLIEFSPGRELSTLADSLYALQEGDLVFALS 60
Query: 61 KSAVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNA 120
+ AV+FA L W YF +G+ TA + + V YP +E SE LLQL
Sbjct: 61 QHAVEFAQAQLQQENKRWPTAPRYFAIGRTTALALHTVSGIDVRYPLDREISEVLLQLPE 120
Query: 121 MQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRAGIQ 180
+Q ++ K L+LRGNGGREL E RGA V ECY+R Y+ AE+ G+
Sbjct: 121 LQTVAGKRALVLRGNGGRELLGETLTDRGAEVTFCECYQRCAKYYDGAEEAMRWHLRGVD 180
Query: 181 TIVVTSAEILTQLVDFVPQ-NEHNWLKSCQLITVSERIAHLAEALGWQNVVISPRADNQT 239
T+VVTS E+L QL +PQ NWL C+L+ VSER+A+LA LGWQ++ I+ ADN
Sbjct: 181 TLVVTSGEMLQQLWSLIPQWYRENWLLRCRLLVVSERLANLARELGWQDIRIADNADNDA 240
Query: 240 LLQTL 244
LL+ L
Sbjct: 241 LLRAL 245
>gi|16762197|ref|NP_457814.1| uroporphyrinogen-III synthetase [Salmonella enterica subsp.
enterica serovar Typhi str. CT18]
gi|29143686|ref|NP_807028.1| uroporphyrinogen-III synthetase [Salmonella enterica subsp.
enterica serovar Typhi Ty2]
gi|25512549|pir||AE0920 uroporphyrinogen III synthase [imported] - Salmonella enterica
subsp. enterica serovar Typhi (strain CT18)
gi|16504501|emb|CAD09383.1| uroporphyrinogen III synthase [Salmonella enterica subsp. enterica
serovar Typhi]
gi|29139321|gb|AAO70888.1| uroporphyrinogen III synthase [Salmonella enterica subsp. enterica
serovar Typhi Ty2]
Length = 246
Score = 188 bits (478), Expect = 2e-46, Method: Composition-based stats.
Identities = 105/246 (42%), Positives = 140/246 (56%), Gaps = 3/246 (1%)
Query: 1 MAVLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVS 60
M++L+TRP G+ LV L G VA PL +G EL L ++ A L D VFA+S
Sbjct: 1 MSILITRPSPAGEALVSRLRALGQVAWSFPLIEFVAGRELPTLADRLATLTENDLVFALS 60
Query: 61 KSAVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNA 120
+ +V FA L G W YF++G+ TA + + YP +E SE LLQL
Sbjct: 61 QHSVAFAHAQLQRDGRNWPASPRYFSIGRTTALALHTVSGFDIRYPLDREISEALLQLPE 120
Query: 121 MQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRAGIQ 180
+Q+++ K LILRGNGGREL E RGA V ECY+R Y+ AE+ G+
Sbjct: 121 LQNIAGKRALILRGNGGRELLGETLTVRGAEVSFCECYQRCAKHYDGAEEAMRWHTRGVT 180
Query: 181 TIVVTSAEILTQLVDFVPQ--NEHNWLKSCQLITVSERIAHLAEALGWQNVVISPRADNQ 238
T+VVTS E+L +L PQ EH WL C+L+ VSER+AHLA LGWQ++ ++ ADN
Sbjct: 181 TLVVTSGEMLQRLWSLTPQWYREH-WLLRCRLLVVSERLAHLARELGWQDIKVADNADND 239
Query: 239 TLLQTL 244
LL+ L
Sbjct: 240 ALLRAL 245
>gi|56415792|ref|YP_152867.1| uroporphyrinogen-III synthetase [Salmonella enterica subsp.
enterica serovar Paratyphi A str. ATCC 9150]
gi|56130049|gb|AAV79555.1| uroporphyrinogen III synthase [Salmonella enterica subsp. enterica
serovar Paratyphi A str. ATCC 9150]
Length = 246
Score = 188 bits (478), Expect = 2e-46, Method: Composition-based stats.
Identities = 105/246 (42%), Positives = 139/246 (56%), Gaps = 3/246 (1%)
Query: 1 MAVLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVS 60
M++L+TRP G+ LV L G VA PL +G EL L ++ A L D VFA+S
Sbjct: 1 MSILITRPSPAGEALVSRLRALGQVAWSFPLIEFVAGRELPTLADRLATLTENDLVFALS 60
Query: 61 KSAVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNA 120
+ AV FA L G W YF +G+ TA + + YP +E SE LLQL
Sbjct: 61 QHAVAFAHAQLQRDGRNWPASPRYFAIGRTTALALHTVSGFDIRYPLDREISEALLQLPE 120
Query: 121 MQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRAGIQ 180
+Q+++ K LILRGNGGREL E RGA V ECY+R Y+ AE+ G+
Sbjct: 121 LQNIAGKRALILRGNGGRELLGETLTARGAEVSFCECYQRCAKHYDGAEEAMRWHTRGVT 180
Query: 181 TIVVTSAEILTQLVDFVPQ--NEHNWLKSCQLITVSERIAHLAEALGWQNVVISPRADNQ 238
T+VVTS E+L +L P+ EH WL C+L+ VSER+AHLA LGWQ++ ++ ADN
Sbjct: 181 TLVVTSGEMLQRLWSLTPEWYREH-WLLRCRLLVVSERLAHLARELGWQDIKVADNADND 239
Query: 239 TLLQTL 244
LL+ L
Sbjct: 240 ALLRAL 245
>gi|16767208|ref|NP_462823.1| uroporphyrinogen-III synthetase [Salmonella typhimurium LT2]
gi|17865664|sp|Q9L6Q3|HEM4_SALTY Uroporphyrinogen-III synthase (UROS) (Uroporphyrinogen-III
cosynthetase) (Hydroxymethylbilane hydrolyase
[cyclizing])
gi|6960264|gb|AAF33454.1| 83% identity with E. coli uroporphyrinogen-III synthase (HEMD)
(SP:P09126) [Salmonella typhimurium LT2]
gi|16422501|gb|AAL22782.1| uroporphyrinogen III synthase [Salmonella typhimurium LT2]
Length = 246
Score = 188 bits (477), Expect = 3e-46, Method: Composition-based stats.
Identities = 106/246 (43%), Positives = 139/246 (56%), Gaps = 3/246 (1%)
Query: 1 MAVLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVS 60
M++L+TRP G+ LV L G VA PL +G EL L ++ A L D VFA+S
Sbjct: 1 MSILITRPSPAGEALVSRLRALGQVAWSFPLIEFVAGRELPTLADRLATLTENDLVFALS 60
Query: 61 KSAVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNA 120
+ AV FA L G W YF +G+ TA + + YP +E SE LLQL
Sbjct: 61 QHAVAFAHAQLQRDGRNWPVAPRYFAIGRTTALALHTVSGFDIRYPLDREISEALLQLPE 120
Query: 121 MQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRAGIQ 180
+Q+++ K LILRGNGGREL E RGA V ECY+R Y+ AE+ G+
Sbjct: 121 LQNIAGKRALILRGNGGRELLGETLTARGAEVSFCECYQRCAKHYDGAEEAMRWHTRGVT 180
Query: 181 TIVVTSAEILTQLVDFVPQ--NEHNWLKSCQLITVSERIAHLAEALGWQNVVISPRADNQ 238
T+VVTS E+L +L PQ EH WL C+L+ VSER+AHLA LGWQ++ ++ ADN
Sbjct: 181 TLVVTSGEMLQRLWSLTPQWYREH-WLLRCRLLVVSERLAHLARELGWQDIKVADNADND 239
Query: 239 TLLQTL 244
LL+ L
Sbjct: 240 ALLRAL 245
>gi|62182408|ref|YP_218825.1| uroporphyrinogen-III synthetase [Salmonella enterica subsp.
enterica serovar Choleraesuis str. SC-B67]
gi|62130041|gb|AAX67744.1| uroporphyrinogen III synthase [Salmonella enterica subsp. enterica
serovar Choleraesuis str. SC-B67]
Length = 246
Score = 187 bits (476), Expect = 4e-46, Method: Composition-based stats.
Identities = 105/246 (42%), Positives = 138/246 (56%), Gaps = 3/246 (1%)
Query: 1 MAVLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVS 60
M++L+TRP G+ LV L G VA PL +G EL L ++ A L D VFA+S
Sbjct: 1 MSILITRPSPAGEALVSRLRALGQVAWSFPLIEFVAGRELPTLADRLATLTENDLVFALS 60
Query: 61 KSAVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNA 120
+ AV FA L G W YF +G+ TA + + YP +E SE LLQL
Sbjct: 61 QHAVAFAHAQLQRDGRNWPASPRYFAIGRTTALALHTVSGFDIRYPLDREISEALLQLPE 120
Query: 121 MQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRAGIQ 180
+Q+++ K LILRGNGGREL E RGA V ECY+R Y+ AE+ G+
Sbjct: 121 LQNIAGKRALILRGNGGRELLGETLTARGAEVSFCECYQRCAKHYDGAEEAMRWHTRGVT 180
Query: 181 TIVVTSAEILTQLVDFVPQ--NEHNWLKSCQLITVSERIAHLAEALGWQNVVISPRADNQ 238
T+VVTS E+L +L PQ EH WL C+L+ VSER+AHLA LGWQ++ ++ DN
Sbjct: 181 TLVVTSGEMLQRLWSLTPQWYREH-WLLRCRLLVVSERLAHLARELGWQDIKVADNVDND 239
Query: 239 TLLQTL 244
LL+ L
Sbjct: 240 ALLRAL 245
>gi|156935871|ref|YP_001439787.1| hypothetical protein ESA_03754 [Enterobacter sakazakii ATCC
BAA-894]
gi|156534125|gb|ABU78951.1| hypothetical protein ESA_03754 [Enterobacter sakazakii ATCC
BAA-894]
Length = 246
Score = 187 bits (476), Expect = 4e-46, Method: Composition-based stats.
Identities = 105/245 (42%), Positives = 139/245 (56%), Gaps = 1/245 (0%)
Query: 1 MAVLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVS 60
M +LVTRP G++LV L G A PL G EL +LP L D +FA+S
Sbjct: 1 MTILVTRPSPAGEELVSRLRALGQEAWSFPLIEFCPGRELPQLPALLDALAPHDLLFALS 60
Query: 61 KSAVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNA 120
+ AV FA L G W + F +G+ TA + + VHYP +E SE LLQL
Sbjct: 61 QHAVSFANAHLQRLGQRWPRAVEAFAIGRTTALALHQVSGLHVHYPRDREISEVLLQLPE 120
Query: 121 MQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRAGIQ 180
+Q+++ K LILRGNGGREL E +RGA V ECY+R +Y+ E+ GI
Sbjct: 121 LQNVAGKRALILRGNGGRELLGETLTERGATVTFCECYQRSAKIYDGTEEAHRWHTRGIT 180
Query: 181 TIVVTSAEILTQLVDFVPQ-NEHNWLKSCQLITVSERIAHLAEALGWQNVVISPRADNQT 239
T+VVTS E+L QL D +P NWL C+L+ VSER+A +A LGWQN++++ ADN
Sbjct: 181 TLVVTSGEMLRQLHDLMPPWYRENWLLRCRLVVVSERLATIARELGWQNILVADNADNDA 240
Query: 240 LLQTL 244
LL+ L
Sbjct: 241 LLRAL 245
>gi|94676811|ref|YP_588540.1| uroporphyrinogen-III synthase [Baumannia cicadellinicola str. Hc
(Homalodisca coagulata)]
gi|94219961|gb|ABF14120.1| uroporphyrinogen-III synthase [Baumannia cicadellinicola str. Hc
(Homalodisca coagulata)]
Length = 246
Score = 186 bits (473), Expect = 8e-46, Method: Composition-based stats.
Identities = 100/245 (40%), Positives = 139/245 (56%), Gaps = 1/245 (0%)
Query: 1 MAVLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVS 60
M++LVTRP G++LV+ L G +A HLPL R G +L L F L D +F +S
Sbjct: 1 MSILVTRPSPAGEKLVEKLRAYGKLAWHLPLIRFLPGMDLPMLGRHFMALCQDDLLFILS 60
Query: 61 KSAVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNA 120
+ A+ +A L W L YFTVG + + +PV+YP E SEGLL L +
Sbjct: 61 QHAIVYAHSWLLQQSINWPARLRYFTVGSTSGLLLHQFSGLPVNYPHQCETSEGLLNLPS 120
Query: 121 MQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRAGIQ 180
+ + + LILRGNGGR++ + QRG VE ECYRR PI Y+ EQ GI
Sbjct: 121 LASIDGRRALILRGNGGRKILKQTLLQRGVKVEDCECYRRYPIPYDGNEQGRRLLSLGIN 180
Query: 181 TIVVTSAEILTQLVDFVPQNEHNWLK-SCQLITVSERIAHLAEALGWQNVVISPRADNQT 239
T+V+TS E+L Q +P++ H +L C+LI VSER+A LA LGWQ+++I D+
Sbjct: 181 TLVITSGEMLQQFYTLIPKSYHYFLLIQCRLIVVSERLAILAHKLGWQDIIIVNITDHDA 240
Query: 240 LLQTL 244
L++ L
Sbjct: 241 LMRVL 245
>gi|71892350|ref|YP_278084.1| uroporphyrinogen-III synthetase [Candidatus Blochmannia
pennsylvanicus str. BPEN]
gi|71796456|gb|AAZ41207.1| uroporphyrinogen III synthase [Candidatus Blochmannia
pennsylvanicus str. BPEN]
Length = 249
Score = 185 bits (470), Expect = 2e-45, Method: Composition-based stats.
Identities = 99/247 (40%), Positives = 137/247 (55%), Gaps = 1/247 (0%)
Query: 1 MAVLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVS 60
M +L+TRP G+QLV+ L G A HLPL +G EL L K L GD++ +S
Sbjct: 1 MNILITRPSPYGEQLVNKLLSFGKFAYHLPLIYFSTGKELCSLEQKLNLLSEGDFLCIIS 60
Query: 61 KSAVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNA 120
+ A+ +A L G W L Y+++G T+ + + V YPT QE SE LLQL
Sbjct: 61 QHAIKYAHNQLLNMGISWPTKLAYYSIGHATSVMMYKLSGILVKYPTIQETSENLLQLPE 120
Query: 121 MQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRAGIQ 180
+ K LILRGN GR + + Q+RG V ECY R+P YN +Q S I+
Sbjct: 121 LMYSYGKRALILRGNNGRTILDDTLQRRGVFVASCECYTRQPFRYNREKQLSNLLGLNIR 180
Query: 181 TIVVTSAEILTQLVDFVPQN-EHNWLKSCQLITVSERIAHLAEALGWQNVVISPRADNQT 239
T+VVTS EIL L +P++ +WL C+LI VS R+A LA LGW N++I+ A+N+
Sbjct: 181 TVVVTSGEILQHLYYLIPESYRTSWLIRCKLIVVSVRLAKLARRLGWTNIIIAQSANNEI 240
Query: 240 LLQTLLQ 246
L L++
Sbjct: 241 LFHLLIK 247
>gi|152972792|ref|YP_001337938.1| uroporphyrinogen-III synthetase [Klebsiella pneumoniae subsp.
pneumoniae MGH 78578]
gi|150957641|gb|ABR79671.1| uroporphyrinogen-III synthetase [Klebsiella pneumoniae subsp.
pneumoniae MGH 78578]
Length = 246
Score = 184 bits (466), Expect = 5e-45, Method: Composition-based stats.
Identities = 102/245 (41%), Positives = 138/245 (56%), Gaps = 1/245 (0%)
Query: 1 MAVLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVS 60
M++LVTRP +G+ LV L G VA PL G EL L + A+L D +FA+S
Sbjct: 1 MSILVTRPLPQGEALVSRLRAMGRVAWSFPLIEFTPGRELPALGDALARLGPDDLLFALS 60
Query: 61 KSAVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNA 120
+ AV+FA L G W YF +G+ TA + +HYP +E SE LLQL
Sbjct: 61 QHAVEFAHARLQQQGLPWPTSPRYFAIGRTTALALHTVSGQHIHYPLDREISEVLLQLPE 120
Query: 121 MQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRAGIQ 180
+Q+++ K LILRGNGGREL +RGA V ECY+R Y+ AE+ + G+
Sbjct: 121 LQNIAGKNALILRGNGGRELLGATLTERGARVTFCECYQRSAKHYDGAEEAMRWQSRGVT 180
Query: 181 TIVVTSAEILTQLVDFVPQ-NEHNWLKSCQLITVSERIAHLAEALGWQNVVISPRADNQT 239
T+VVTS E+L QL +PQ WL C+++ VSER+A A LGWQ + ++ ADN
Sbjct: 181 TLVVTSGEMLQQLWSLIPQWYREQWLLHCRVVVVSERLALQARELGWQEIQVADSADNDA 240
Query: 240 LLQTL 244
LL+ L
Sbjct: 241 LLRAL 245
>gi|15804392|ref|NP_290432.1| uroporphyrinogen-III synthetase [Escherichia coli O157:H7 EDL933]
gi|15833988|ref|NP_312761.1| uroporphyrinogen-III synthetase [Escherichia coli O157:H7 str.
Sakai]
gi|75197687|ref|ZP_00707757.1| COG1587: Uroporphyrinogen-III synthase [Escherichia coli HS]
gi|12518668|gb|AAG58996.1|AE005611_6 uroporphyrinogen III synthase [Escherichia coli O157:H7 EDL933]
gi|13364210|dbj|BAB38157.1| uroporphyrinogen III synthase [Escherichia coli O157:H7 str. Sakai]
gi|157068957|gb|ABV08212.1| uroporphyrinogen-III synthase [Escherichia coli HS]
Length = 246
Score = 182 bits (463), Expect = 1e-44, Method: Composition-based stats.
Identities = 104/246 (42%), Positives = 142/246 (57%), Gaps = 3/246 (1%)
Query: 1 MAVLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVS 60
M++LVTRP G++LV L G VA H PL G +L +L ++ A L D +FA+S
Sbjct: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGRQLPQLADQLAALGESDLLFALS 60
Query: 61 KSAVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNA 120
+ AV FA L W +YF +G+ TA + + YP +E SE LLQL
Sbjct: 61 QHAVAFAQSQLHQQDRKWPRLPNYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120
Query: 121 MQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRAGIQ 180
+Q+++ K LILRGNGGREL + RGA V ECY+R I Y+ AE+ + +
Sbjct: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQSREVT 180
Query: 181 TIVVTSAEILTQLVDFVPQ--NEHNWLKSCQLITVSERIAHLAEALGWQNVVISPRADNQ 238
T+VVTS E+L QL +PQ EH WL C+L+ VSER+A LA LGWQ++ ++ ADN
Sbjct: 181 TVVVTSGEMLQQLWSLIPQWYREH-WLLHCRLLVVSERLAKLARELGWQDIKVADNADND 239
Query: 239 TLLQTL 244
LL+ L
Sbjct: 240 ALLRAL 245
>gi|75236887|ref|ZP_00720956.1| COG1587: Uroporphyrinogen-III synthase [Escherichia coli F11]
gi|91213325|ref|YP_543311.1| uroporphyrinogen-III synthase [Escherichia coli UTI89]
gi|110644127|ref|YP_671857.1| uroporphyrinogen-III synthase HemD [Escherichia coli 536]
gi|117626061|ref|YP_859384.1| uroporphyrinogen-III synthetase [Escherichia coli APEC O1]
gi|91074899|gb|ABE09780.1| uroporphyrinogen-III synthase [Escherichia coli UTI89]
gi|110345719|gb|ABG71956.1| uroporphyrinogen-III synthase HemD [Escherichia coli 536]
gi|115515185|gb|ABJ03260.1| uroporphyrinogen-III synthetase [Escherichia coli APEC O1]
Length = 246
Score = 182 bits (463), Expect = 1e-44, Method: Composition-based stats.
Identities = 104/246 (42%), Positives = 141/246 (57%), Gaps = 3/246 (1%)
Query: 1 MAVLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVS 60
M++LVTRP G++LV L G VA H PL G +L +L ++ A L D +FA+S
Sbjct: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGRQLPQLADQLAALGESDLLFALS 60
Query: 61 KSAVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNA 120
+ AV FA L W YF +G+ TA + + YP +E SE LLQL
Sbjct: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120
Query: 121 MQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRAGIQ 180
+Q+++ K LILRGNGGREL + RGA V ECY+R I Y+ AE+ + +
Sbjct: 121 LQNIAGKRALILRGNGGRELIGDSLTARGAEVTFCECYQRCAIHYDGAEEAMRWQSREVT 180
Query: 181 TIVVTSAEILTQLVDFVPQ--NEHNWLKSCQLITVSERIAHLAEALGWQNVVISPRADNQ 238
T+VVTS E+L QL +PQ EH WL C+L+ VSER+A LA LGWQ++ ++ ADN
Sbjct: 181 TVVVTSGEMLQQLWSLIPQWYREH-WLLRCRLLVVSERLAKLARELGWQDIKVADNADND 239
Query: 239 TLLQTL 244
LL+ L
Sbjct: 240 ALLRAL 245
>gi|83585947|ref|ZP_00924586.1| COG1587: Uroporphyrinogen-III synthase [Escherichia coli 101-1]
Length = 246
Score = 182 bits (462), Expect = 2e-44, Method: Composition-based stats.
Identities = 104/246 (42%), Positives = 141/246 (57%), Gaps = 3/246 (1%)
Query: 1 MAVLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVS 60
M++LVTRP G++LV L G VA H PL G +L +L ++ A L D +FA+S
Sbjct: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGRQLPQLADQLAALGESDLLFALS 60
Query: 61 KSAVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNA 120
+ AV FA L W YF +G+ TA + + YP +E SE LLQL
Sbjct: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120
Query: 121 MQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRAGIQ 180
+Q+++ K LILRGNGGREL + RGA V ECY+R I Y+ AE+ + +
Sbjct: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQSREVT 180
Query: 181 TIVVTSAEILTQLVDFVPQ--NEHNWLKSCQLITVSERIAHLAEALGWQNVVISPRADNQ 238
T+VVTS E+L QL +PQ EH WL C+L+ VSER+A LA LGWQ++ ++ ADN
Sbjct: 181 TVVVTSGEMLQQLWSLIPQWYREH-WLLHCRLLVVSERLAKLARELGWQDIKVADNADND 239
Query: 239 TLLQTL 244
LL+ L
Sbjct: 240 ALLRAL 245
>gi|51594539|ref|YP_068730.1| uroporphyrinogen-III synthetase [Yersinia pseudotuberculosis IP
32953]
gi|51587821|emb|CAH19423.1| uroporphyrinogen-III synthase [Yersinia pseudotuberculosis IP
32953]
Length = 249
Score = 182 bits (461), Expect = 2e-44, Method: Composition-based stats.
Identities = 102/245 (41%), Positives = 142/245 (57%), Gaps = 1/245 (0%)
Query: 1 MAVLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVS 60
M +LVTRP G+QLV L G VA H PL G +L +LP ++ GD VFA+S
Sbjct: 1 MTILVTRPSPAGEQLVTRLRALGRVAYHAPLIDFSPGRDLPKLPELLQDMRAGDLVFALS 60
Query: 61 KSAVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNA 120
++AV +A L W L Y+ +G+ TA + + V +P E SE LL L
Sbjct: 61 QNAVRYANPLLKRNKLSWPVQLSYYAIGRTTALALHTASRLHVTFPPMGETSEMLLSLPL 120
Query: 121 MQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRAGIQ 180
+Q+L+ K L+LRGNGGREL +RGA V ECY+R PI Y+ +EQ++ +RAG+
Sbjct: 121 LQNLAGKKALLLRGNGGRELLGASLAERGAAVTFCECYQRSPIYYDGSEQSAHWQRAGVD 180
Query: 181 TIVVTSAEILTQLVDFVPQ-NEHNWLKSCQLITVSERIAHLAEALGWQNVVISPRADNQT 239
+VVTS E+L Q+ VP +WL C+LI VS+R+A LA +GW V ++ ADN
Sbjct: 181 ILVVTSGEMLQQIYTLVPDYYRSSWLLRCRLIVVSDRLAALATQMGWTEVRVAENADNDA 240
Query: 240 LLQTL 244
L++ L
Sbjct: 241 LIRAL 245
>gi|26250542|ref|NP_756582.1| uroporphyrinogen-III synthetase [Escherichia coli CFT073]
gi|26110972|gb|AAN83156.1|AE016769_271 Uroporphyrinogen-III synthase [Escherichia coli CFT073]
Length = 246
Score = 182 bits (461), Expect = 2e-44, Method: Composition-based stats.
Identities = 104/246 (42%), Positives = 141/246 (57%), Gaps = 3/246 (1%)
Query: 1 MAVLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVS 60
M++LVTRP G++LV L G VA H PL G +L +L ++ A L D +FA+S
Sbjct: 1 MSILVTRPFPAGEELVSRLRTLGQVAWHFPLIEFSPGRQLPQLADQLAALGESDLLFALS 60
Query: 61 KSAVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNA 120
+ AV FA L W YF +G+ TA + + YP +E SE LLQL
Sbjct: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120
Query: 121 MQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRAGIQ 180
+Q+++ K LILRGNGGREL + RGA V ECY+R I Y+ AE+ + +
Sbjct: 121 LQNIAGKRALILRGNGGRELIGDSLTARGAEVTFCECYQRCAIHYDGAEEAMRWQSREVT 180
Query: 181 TIVVTSAEILTQLVDFVPQ--NEHNWLKSCQLITVSERIAHLAEALGWQNVVISPRADNQ 238
T+VVTS E+L QL +PQ EH WL C+L+ VSER+A LA LGWQ++ ++ ADN
Sbjct: 181 TVVVTSGEMLQQLWSLIPQWYREH-WLLRCRLLVVSERLAKLARELGWQDIKVADNADND 239
Query: 239 TLLQTL 244
LL+ L
Sbjct: 240 ALLRAL 245
>gi|82779018|ref|YP_405367.1| uroporphyrinogen III synthase [Shigella dysenteriae Sd197]
gi|81243166|gb|ABB63876.1| uroporphyrinogen III synthase [Shigella dysenteriae Sd197]
Length = 246
Score = 182 bits (461), Expect = 2e-44, Method: Composition-based stats.
Identities = 104/246 (42%), Positives = 141/246 (57%), Gaps = 3/246 (1%)
Query: 1 MAVLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVS 60
M++LVTRP G++LV L G VA H PL G +L +L ++ A L D +FA+S
Sbjct: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGRQLPQLADQLAALGESDLLFALS 60
Query: 61 KSAVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNA 120
+ AV FA L W YF +G+ TA + + YP +E SE LLQL
Sbjct: 61 QHAVAFAQSQLHQQDRKWPRLPTYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120
Query: 121 MQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRAGIQ 180
+Q+++ K LILRGNGGREL + RGA V ECY+R I Y+ AE+ + +
Sbjct: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQSREVT 180
Query: 181 TIVVTSAEILTQLVDFVPQ--NEHNWLKSCQLITVSERIAHLAEALGWQNVVISPRADNQ 238
T+VVTS E+L QL +PQ EH WL C+L+ VSER+A LA LGWQ++ ++ ADN
Sbjct: 181 TVVVTSGEMLQQLWSLIPQWYREH-WLLHCRLLVVSERLAKLARELGWQDIKVADNADND 239
Query: 239 TLLQTL 244
LL+ L
Sbjct: 240 ALLRAL 245
>gi|16123985|ref|NP_407298.1| uroporphyrinogen-III synthetase [Yersinia pestis CO92]
gi|22124295|ref|NP_667718.1| uroporphyrinogen-III synthetase [Yersinia pestis KIM]
gi|45442948|ref|NP_994487.1| uroporphyrinogen-III synthetase [Yersinia pestis biovar Microtus
str. 91001]
gi|77633324|ref|ZP_00795461.1| COG1587: Uroporphyrinogen-III synthase [Yersinia pestis Angola]
gi|108806169|ref|YP_650085.1| uroporphyrinogen-III synthase [Yersinia pestis Antiqua]
gi|108810279|ref|YP_646046.1| uroporphyrinogen-III synthase [Yersinia pestis Nepal516]
gi|145600718|ref|YP_001164794.1| uroporphyrinogen-III synthase [Yersinia pestis Pestoides F]
gi|153948434|ref|YP_001399194.1| uroporphyrinogen-III synthase [Yersinia pseudotuberculosis IP
31758]
gi|153997094|ref|ZP_02022227.1| uroporphyrinogen-III synthase [Yersinia pestis CA88-4125]
gi|21957066|gb|AAM83969.1|AE013638_7 uroporphyrinogen III synthase [Yersinia pestis KIM]
gi|45437815|gb|AAS63364.1| uroporphyrinogen-III synthase [Yersinia pestis biovar Microtus str.
91001]
gi|108773927|gb|ABG16446.1| uroporphyrinogen-III synthase [Yersinia pestis Nepal516]
gi|108778082|gb|ABG12140.1| uroporphyrinogen-III synthase [Yersinia pestis Antiqua]
gi|115349464|emb|CAL22437.1| uroporphyrinogen-III synthase [Yersinia pestis CO92]
gi|145212414|gb|ABP41821.1| uroporphyrinogen-III synthase [Yersinia pestis Pestoides F]
gi|149289400|gb|EDM39478.1| uroporphyrinogen-III synthase [Yersinia pestis CA88-4125]
gi|152959929|gb|ABS47390.1| uroporphyrinogen-III synthase [Yersinia pseudotuberculosis IP
31758]
Length = 249
Score = 181 bits (460), Expect = 3e-44, Method: Composition-based stats.
Identities = 102/245 (41%), Positives = 142/245 (57%), Gaps = 1/245 (0%)
Query: 1 MAVLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVS 60
M +LVTRP G+QLV L G VA H PL G +L +LP ++ GD VFA+S
Sbjct: 1 MTILVTRPSPAGEQLVTRLRALGRVAYHAPLIDFSPGRDLPKLPELLQDMQAGDLVFALS 60
Query: 61 KSAVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNA 120
++AV +A L W L Y+ +G+ TA + + V +P E SE LL L
Sbjct: 61 QNAVRYANPLLKRNKLSWPVQLSYYAIGRTTALALHTASRLHVTFPPMGETSEMLLSLPL 120
Query: 121 MQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRAGIQ 180
+Q+L+ K L+LRGNGGREL +RGA V ECY+R PI Y+ +EQ++ +RAG+
Sbjct: 121 LQNLAGKKALLLRGNGGRELLGASLAERGAAVTFCECYQRSPIYYDGSEQSAHWQRAGVD 180
Query: 181 TIVVTSAEILTQLVDFVPQ-NEHNWLKSCQLITVSERIAHLAEALGWQNVVISPRADNQT 239
+VVTS E+L Q+ VP +WL C+LI VS+R+A LA +GW V ++ ADN
Sbjct: 181 ILVVTSGEMLQQIYTLVPDYYRSSWLLRCRLIVVSDRLAALATQMGWTEVRVAENADNDA 240
Query: 240 LLQTL 244
L++ L
Sbjct: 241 LIRAL 245
>gi|82546155|ref|YP_410102.1| uroporphyrinogen III synthase [Shigella boydii Sb227]
gi|81247566|gb|ABB68274.1| uroporphyrinogen III synthase [Shigella boydii Sb227]
Length = 246
Score = 180 bits (457), Expect = 5e-44, Method: Composition-based stats.
Identities = 103/246 (41%), Positives = 140/246 (56%), Gaps = 3/246 (1%)
Query: 1 MAVLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVS 60
M++LVTRP G++LV L G VA H PL G +L +L ++ A L D +FA+S
Sbjct: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGRQLPQLADQLAALGESDLLFALS 60
Query: 61 KSAVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNA 120
+ AV FA L W YF +G+ TA + + YP +E SE LLQL
Sbjct: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120
Query: 121 MQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRAGIQ 180
+Q+++ K LILRGNGGREL + RGA V ECY+R I Y+ AE+ + +
Sbjct: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQSREVT 180
Query: 181 TIVVTSAEILTQLVDFVPQ--NEHNWLKSCQLITVSERIAHLAEALGWQNVVISPRADNQ 238
+VVTS E+L QL +PQ EH WL C+L+ VSER+A LA LGWQ++ ++ ADN
Sbjct: 181 MVVVTSGEMLQQLWSLIPQWYREH-WLLRCRLLVVSERLAKLARELGWQDIKVADNADND 239
Query: 239 TLLQTL 244
LL+ L
Sbjct: 240 ALLRAL 245
>gi|75188546|ref|ZP_00701813.1| COG1587: Uroporphyrinogen-III synthase [Escherichia coli E24377A]
gi|75209569|ref|ZP_00709790.1| COG1587: Uroporphyrinogen-III synthase [Escherichia coli B171]
gi|75230765|ref|ZP_00717228.1| COG1587: Uroporphyrinogen-III synthase [Escherichia coli B7A]
gi|75238252|ref|ZP_00722251.1| COG1587: Uroporphyrinogen-III synthase [Escherichia coli E110019]
gi|75256272|ref|ZP_00727950.1| COG1587: Uroporphyrinogen-III synthase [Escherichia coli E22]
gi|157078769|gb|ABV18477.1| uroporphyrinogen-III synthase [Escherichia coli E24377A]
Length = 246
Score = 180 bits (457), Expect = 6e-44, Method: Composition-based stats.
Identities = 103/246 (41%), Positives = 140/246 (56%), Gaps = 3/246 (1%)
Query: 1 MAVLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVS 60
M++LVTRP G++LV L G VA H PL G +L +L ++ A L D +FA+S
Sbjct: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGRQLPQLADQLAALGESDLLFALS 60
Query: 61 KSAVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNA 120
+ AV FA L W YF +G+ TA + + YP +E SE LLQL
Sbjct: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120
Query: 121 MQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRAGIQ 180
+Q+++ K LILRGNGGREL + RGA V ECY+R I Y+ AE+ + +
Sbjct: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQSREVT 180
Query: 181 TIVVTSAEILTQLVDFVPQ--NEHNWLKSCQLITVSERIAHLAEALGWQNVVISPRADNQ 238
+VVTS E+L QL +PQ EH WL C+L+ VSER+A LA LGWQ++ ++ ADN
Sbjct: 181 MVVVTSGEMLQQLWSLIPQWYREH-WLLHCRLLVVSERLAKLARELGWQDIKVADNADND 239
Query: 239 TLLQTL 244
LL+ L
Sbjct: 240 ALLRAL 245
>gi|75512637|ref|ZP_00735149.1| COG1587: Uroporphyrinogen-III synthase [Escherichia coli 53638]
gi|124530458|ref|ZP_01701116.1| Uroporphyrinogen-III synthase [Escherichia coli B]
gi|124499224|gb|EAY46717.1| Uroporphyrinogen-III synthase [Escherichia coli B]
Length = 246
Score = 180 bits (457), Expect = 6e-44, Method: Composition-based stats.
Identities = 103/246 (41%), Positives = 140/246 (56%), Gaps = 3/246 (1%)
Query: 1 MAVLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVS 60
M++LVTRP G++LV L G VA H PL G +L +L ++ A L D +FA+S
Sbjct: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60
Query: 61 KSAVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNA 120
+ AV FA L W YF +G+ TA + + YP +E SE LLQL
Sbjct: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120
Query: 121 MQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRAGIQ 180
+Q+++ K LILRGNGGREL + RGA V ECY+R I Y+ AE+ + +
Sbjct: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQSREVT 180
Query: 181 TIVVTSAEILTQLVDFVPQ--NEHNWLKSCQLITVSERIAHLAEALGWQNVVISPRADNQ 238
+VVTS E+L QL +PQ EH WL C+L+ VSER+A LA LGWQ++ ++ ADN
Sbjct: 181 MVVVTSGEMLQQLWSLIPQWYREH-WLLHCRLLVVSERLAKLARELGWQDIKVADNADND 239
Query: 239 TLLQTL 244
LL+ L
Sbjct: 240 ALLRAL 245
>gi|16131656|ref|NP_418248.1| uroporphyrinogen III synthase [Escherichia coli K12]
gi|89110216|ref|AP_003996.1| uroporphyrinogen III synthase [Escherichia coli W3110]
gi|122848|sp|P09126|HEM4_ECOLI Uroporphyrinogen-III synthase (UROS) (Uroporphyrinogen-III
cosynthetase) (Hydroxymethylbilane hydrolyase
[cyclizing])
gi|41667|emb|CAA31133.1| unnamed protein product [Escherichia coli]
gi|148203|gb|AAA67600.1| uroporphyrinogen III synthase [Escherichia coli]
gi|1790236|gb|AAC76807.1| uroporphyrinogen III synthase [Escherichia coli K12]
gi|85676247|dbj|BAE77497.1| uroporphyrinogen III synthase [Escherichia coli W3110]
Length = 246
Score = 180 bits (456), Expect = 8e-44, Method: Composition-based stats.
Identities = 103/246 (41%), Positives = 140/246 (56%), Gaps = 3/246 (1%)
Query: 1 MAVLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVS 60
M++LVTRP G++LV L G VA H PL G +L +L ++ A L D +FA+S
Sbjct: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60
Query: 61 KSAVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNA 120
+ AV FA L W YF +G+ TA + + YP +E SE LLQL
Sbjct: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120
Query: 121 MQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRAGIQ 180
+Q+++ K LILRGNGGREL + RGA V ECY+R I Y+ AE+ + +
Sbjct: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180
Query: 181 TIVVTSAEILTQLVDFVPQ--NEHNWLKSCQLITVSERIAHLAEALGWQNVVISPRADNQ 238
+VVTS E+L QL +PQ EH WL C+L+ VSER+A LA LGWQ++ ++ ADN
Sbjct: 181 MVVVTSGEMLQQLWSLIPQWYREH-WLLHCRLLVVSERLAKLARELGWQDIKVADNADND 239
Query: 239 TLLQTL 244
LL+ L
Sbjct: 240 ALLRAL 245
>gi|146336|gb|AAA23956.1| uroporphyrinogen-III cosynthetase (EC 4.2.1.75)
Length = 246
Score = 180 bits (456), Expect = 8e-44, Method: Composition-based stats.
Identities = 103/246 (41%), Positives = 140/246 (56%), Gaps = 3/246 (1%)
Query: 1 MAVLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVS 60
M++LVTRP G++LV L G VA H PL G +L +L ++ A L D +FA+S
Sbjct: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60
Query: 61 KSAVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNA 120
+ AV FA L W YF +G+ TA + + YP +E SE LLQL
Sbjct: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120
Query: 121 MQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRAGIQ 180
+Q+++ K LILRGNGGREL + RGA V ECY+R I Y+ AE+ + +
Sbjct: 121 LQNIAGKRALILRGNGGRELIGDTLAARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180
Query: 181 TIVVTSAEILTQLVDFVPQ--NEHNWLKSCQLITVSERIAHLAEALGWQNVVISPRADNQ 238
+VVTS E+L QL +PQ EH WL C+L+ VSER+A LA LGWQ++ ++ ADN
Sbjct: 181 MVVVTSGEMLQQLWSLIPQWYREH-WLLHCRLLVVSERLAKLARELGWQDIKVADNADND 239
Query: 239 TLLQTL 244
LL+ L
Sbjct: 240 ALLRAL 245
>gi|74314315|ref|YP_312734.1| uroporphyrinogen III synthase [Shigella sonnei Ss046]
gi|73857792|gb|AAZ90499.1| uroporphyrinogen III synthase [Shigella sonnei Ss046]
Length = 246
Score = 179 bits (455), Expect = 1e-43, Method: Composition-based stats.
Identities = 103/246 (41%), Positives = 141/246 (57%), Gaps = 3/246 (1%)
Query: 1 MAVLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVS 60
M++LVTRP G++LV L G VA H PL G +L +L ++ A L D +FA+S
Sbjct: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60
Query: 61 KSAVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNA 120
+ AV FA L W +YF +G+ TA + + YP +E SE LLQL
Sbjct: 61 QHAVAFAQSQLHQQDRKWPRLPNYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120
Query: 121 MQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRAGIQ 180
+Q+++ K LILRGNGGREL + RGA V ECY+R I Y+ AE+ + +
Sbjct: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQSREVT 180
Query: 181 TIVVTSAEILTQLVDFVPQ--NEHNWLKSCQLITVSERIAHLAEALGWQNVVISPRADNQ 238
T+VVTS E+L QL +PQ EH WL C+L+ VSER+A LA LGWQ++ ++ A N
Sbjct: 181 TVVVTSGEMLQQLWSLIPQWYREH-WLLHCRLLVVSERLAKLARELGWQDIKVADNAAND 239
Query: 239 TLLQTL 244
LL+ L
Sbjct: 240 ALLRAL 245
>gi|24115096|ref|NP_709606.1| uroporphyrinogen-III synthetase [Shigella flexneri 2a str. 301]
gi|30064903|ref|NP_839074.1| uroporphyrinogen-III synthetase [Shigella flexneri 2a str. 2457T]
gi|83569365|ref|ZP_00920820.1| COG1587: Uroporphyrinogen-III synthase [Shigella dysenteriae 1012]
gi|110807508|ref|YP_691028.1| uroporphyrinogen III synthase [Shigella flexneri 5 str. 8401]
gi|24054363|gb|AAN45313.1| uroporphyrinogen III synthase [Shigella flexneri 2a str. 301]
gi|30043163|gb|AAP18885.1| uroporphyrinogen III synthase [Shigella flexneri 2a str. 2457T]
gi|110617056|gb|ABF05723.1| uroporphyrinogen III synthase [Shigella flexneri 5 str. 8401]
Length = 246
Score = 179 bits (454), Expect = 1e-43, Method: Composition-based stats.
Identities = 103/246 (41%), Positives = 140/246 (56%), Gaps = 3/246 (1%)
Query: 1 MAVLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVS 60
M++LVTRP G++LV L G VA H PL G +L +L ++ A L D +FA+S
Sbjct: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGRQLPQLADQLAALGESDLLFALS 60
Query: 61 KSAVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNA 120
+ AV FA L W YF +G+ TA + + YP +E SE LLQL
Sbjct: 61 QHAVAFAQSQLHQQDRKWPQLPTYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120
Query: 121 MQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRAGIQ 180
+Q+++ K LILRGNGGREL + RGA V ECY+R I Y+ AE+ + +
Sbjct: 121 LQNIAGKRALILRGNGGRELIGDTLTVRGAEVTFCECYQRCAIHYDGAEEAMRWQSREVT 180
Query: 181 TIVVTSAEILTQLVDFVPQ--NEHNWLKSCQLITVSERIAHLAEALGWQNVVISPRADNQ 238
+VVTS E+L QL +PQ EH WL C+L+ VSER+A LA LGWQ++ ++ ADN
Sbjct: 181 MVVVTSGEMLQQLWSLIPQWYREH-WLLHCRLLVVSERLAKLARELGWQDIKVADNADND 239
Query: 239 TLLQTL 244
LL+ L
Sbjct: 240 ALLRAL 245
>gi|89104221|ref|ZP_01176771.1| COG1587: Uroporphyrinogen-III synthase [Yersinia pestis biovar
Orientalis str. IP275]
Length = 241
Score = 179 bits (454), Expect = 1e-43, Method: Composition-based stats.
Identities = 101/241 (41%), Positives = 139/241 (57%), Gaps = 1/241 (0%)
Query: 1 MAVLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVS 60
M +LVTRP G+QLV L G VA H PL G +L +LP ++ GD VFA+S
Sbjct: 1 MTILVTRPSPAGEQLVTRLRALGRVAYHAPLIDFSPGRDLPKLPELLQDMQAGDLVFALS 60
Query: 61 KSAVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNA 120
++AV +A L W L Y+ +G+ TA + + V +P E SE LL L
Sbjct: 61 QNAVRYANPLLKRNKLSWPVQLSYYAIGRTTALALHTASRLHVTFPPMGETSEMLLSLPL 120
Query: 121 MQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRAGIQ 180
+Q+L+ K L+LRGNGGREL +RGA V ECY+R PI Y+ +EQ++ +RAG+
Sbjct: 121 LQNLAGKKALLLRGNGGRELLGASLAERGAAVTFCECYQRSPIYYDGSEQSAHWQRAGVD 180
Query: 181 TIVVTSAEILTQLVDFVPQ-NEHNWLKSCQLITVSERIAHLAEALGWQNVVISPRADNQT 239
+VVTS E+L Q+ VP +WL C+LI VS+R+A LA +GW V ++ ADN
Sbjct: 181 ILVVTSGEMLQQIYTLVPDYYRSSWLLRCRLIVVSDRLAALATQMGWTEVRVAENADNDA 240
Query: 240 L 240
L
Sbjct: 241 L 241
>gi|75177764|ref|ZP_00697829.1| COG1587: Uroporphyrinogen-III synthase [Shigella boydii BS512]
Length = 246
Score = 179 bits (454), Expect = 1e-43, Method: Composition-based stats.
Identities = 102/246 (41%), Positives = 140/246 (56%), Gaps = 3/246 (1%)
Query: 1 MAVLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVS 60
M++LVTRP G++LV L G VA H PL G +L +L ++ A L D +FA+S
Sbjct: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGRQLPQLADQLAALGESDLLFALS 60
Query: 61 KSAVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNA 120
+ AV FA L W YF +G+ TA + + YP +E SE LLQL
Sbjct: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120
Query: 121 MQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRAGIQ 180
+Q+++ K LILRGNGGREL + RGA V +CY+R I Y+ AE+ + +
Sbjct: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCKCYQRCAIHYDGAEEAMRWQSREVT 180
Query: 181 TIVVTSAEILTQLVDFVPQ--NEHNWLKSCQLITVSERIAHLAEALGWQNVVISPRADNQ 238
+VVTS E+L QL +PQ EH WL C+L+ VSER+A LA LGWQ++ ++ ADN
Sbjct: 181 MVVVTSGEMLQQLWSLIPQWYREH-WLLRCRLLVVSERLAKLARELGWQDIKVADNADND 239
Query: 239 TLLQTL 244
LL+ L
Sbjct: 240 ALLRAL 245
>gi|41676|emb|CAA68776.1| unnamed protein product [Escherichia coli]
Length = 246
Score = 178 bits (451), Expect = 3e-43, Method: Composition-based stats.
Identities = 102/246 (41%), Positives = 139/246 (56%), Gaps = 3/246 (1%)
Query: 1 MAVLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVS 60
M++LVTRP G++LV L G VA H PL G +L +L ++ A L D +FA+S
Sbjct: 1 MSILVTRPSPAGEELVSRLRTLGQVAWHFPLIEFSPGQQLPQLADQLAALGESDLLFALS 60
Query: 61 KSAVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNA 120
+ AV FA L W YF +G+ TA + + YP +E SE LLQL
Sbjct: 61 QHAVAFAQSQLHQQDRKWPRLPDYFAIGRTTALALHTVSGQKILYPQDREISEVLLQLPE 120
Query: 121 MQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRAGIQ 180
+Q+++ K LILRGNGGREL + RGA V ECY+R I Y+ AE+ + +
Sbjct: 121 LQNIAGKRALILRGNGGRELIGDTLTARGAEVTFCECYQRCAIHYDGAEEAMRWQAREVT 180
Query: 181 TIVVTSAEILTQLVDFVPQ--NEHNWLKSCQLITVSERIAHLAEALGWQNVVISPRADNQ 238
+VVTS E+L QL +PQ EH WL C+L+ VSER+A LA LGWQ++ ++ DN
Sbjct: 181 MVVVTSGEMLQQLWSLIPQWYREH-WLLHCRLLVVSERLAKLARELGWQDIKVADNRDND 239
Query: 239 TLLQTL 244
LL+ L
Sbjct: 240 ALLRAL 245
>gi|33520024|ref|NP_878856.1| uroporphyrinogen-III synthetase [Candidatus Blochmannia floridanus]
gi|33504370|emb|CAD83263.1| uroporphyrinogen III synthase [Candidatus Blochmannia floridanus]
Length = 247
Score = 171 bits (434), Expect = 3e-41, Method: Composition-based stats.
Identities = 91/246 (36%), Positives = 139/246 (56%), Gaps = 2/246 (0%)
Query: 1 MAVLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVS 60
M++L+TRP G+ LVD L G A HLPL +G L + L GD++F VS
Sbjct: 1 MSILITRPTPDGEDLVDRLVSIGKSAYHLPLISFSTGKTLFSIKKYLNFLHTGDFLFIVS 60
Query: 61 KSAVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQL-N 119
+ AV +A L ++G W H + Y+++G T+ + + + YP +E SE LLQ
Sbjct: 61 QHAVKYAHIQLLSSGTQWPHKITYYSIGHKTSSKMYSLSGILSKYPQNEETSENLLQFPE 120
Query: 120 AMQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRAGI 179
+ ++S + LIL+GN G Q+RGA V ECY R+PI YN EQ + I
Sbjct: 121 LIYNISGRRALILKGNNGLTTLQHTLQKRGALVLCCECYTRKPIQYNGKEQYNRMITLDI 180
Query: 180 QTIVVTSAEILTQLVDFVPQNEH-NWLKSCQLITVSERIAHLAEALGWQNVVISPRADNQ 238
+ IVVT+ ++L QL +PQ+ +WL + QL+ S R+A A++LGW +++I+ A+N
Sbjct: 181 EIIVVTTTDMLKQLYYLIPQSHRTDWLITRQLVVTSNRLAEYAKSLGWSDIIITKSANNT 240
Query: 239 TLLQTL 244
T+L+ L
Sbjct: 241 TILRAL 246
>gi|33152756|ref|NP_874109.1| possible uroporphyrinogen III synthase [Haemophilus ducreyi
35000HP]
gi|33148980|gb|AAP96498.1| possible uroporphyrinogen III synthase [Haemophilus ducreyi
35000HP]
Length = 251
Score = 170 bits (430), Expect = 8e-41, Method: Composition-based stats.
Identities = 105/247 (42%), Positives = 149/247 (60%), Gaps = 5/247 (2%)
Query: 1 MAVLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVS 60
M VL+T P R Q+LVDM + + AI+ P+F +E GA+L +LP+ ++L GD V +S
Sbjct: 1 MNVLITYPASRAQKLVDMCQQHRIFAIYQPIFSVELGADLLDLPSAMSRLNAGDNVIILS 60
Query: 61 KSAVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNA 120
K A DFA++TL TGF +R DL+YF + A Y TA T PVHYP E LLQL
Sbjct: 61 KEAFDFAWQTLADTGFAYRADLNYFVADKYLAAYVTAKTTRPVHYPDT-EQCNQLLQLGK 119
Query: 121 MQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRAGIQ 180
+ L+DK VLIL R LF Q + V+ + CY + I A Q S+ KRAGI
Sbjct: 120 LLQLTDKKVLILCAEEQRGLFQNQLAE-AKQVQYLACYYHKHIEQLTA-QLSLAKRAGID 177
Query: 181 TIVVTSAEILTQLVDFVPQNEHNWLKSCQLITVSERIAHLAEALGWQN--VVISPRADNQ 238
TI++ + ++L L + + + WL +L+ +S+ IA++AE LGWQ+ V+I+ + DNQ
Sbjct: 178 TILIENEDVLLTLYEQIAAEDCQWLVKTRLVVISQHIANIAEKLGWQSDQVIIAGQTDNQ 237
Query: 239 TLLQTLL 245
TLL T+L
Sbjct: 238 TLLNTML 244
>gi|32490990|ref|NP_871244.1| hypothetical protein WGLp241 [Wigglesworthia glossinidia
endosymbiont of Glossina brevipalpis]
gi|25166196|dbj|BAC24387.1| hemD [Wigglesworthia glossinidia endosymbiont of Glossina
brevipalpis]
Length = 245
Score = 163 bits (412), Expect = 9e-39, Method: Composition-based stats.
Identities = 91/246 (36%), Positives = 144/246 (58%), Gaps = 2/246 (0%)
Query: 1 MAVLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVS 60
M +L+TRP GQ L++M+ K G A +LPL SG L L N F KL+ D + ++S
Sbjct: 1 MTILITRPYPHGQHLINMIRKNGKEAWYLPLIYFTSGIGLLSLTNFFKKLQEKDIICSLS 60
Query: 61 KSAVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNA 120
A +A + W ++Y+ +G+ +A Y + ++ V YP ENSE LL L +
Sbjct: 61 PRATKYANYQILLEKCNWPKKINYYAIGKTSAFYLSKYSKCKVIYPKLTENSENLLDLIS 120
Query: 121 MQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRAGIQ 180
+D+ K +LIL+GN GR+ + + GA + VECY+R I YN + I
Sbjct: 121 KEDVK-KKILILKGNNGRKFLENKLKLYGAYIINVECYKRNFIKYNKYDYLKKIINLKIN 179
Query: 181 TIVVTSAEILTQLVDFVPQNEHN-WLKSCQLITVSERIAHLAEALGWQNVVISPRADNQT 239
T+VVTS+EIL QL + +P N N +L + +L+ VS+RI+ +A+ LGW+N+++S + N+
Sbjct: 180 TLVVTSSEILHQLHNNIPLNYINFFLINFKLVVVSKRISDIADNLGWKNIIVSKSSKNKD 239
Query: 240 LLQTLL 245
++Q+LL
Sbjct: 240 IIQSLL 245
>gi|37678264|ref|NP_932873.1| uroporphyrinogen-III synthetase [Vibrio vulnificus YJ016]
gi|37197003|dbj|BAC92844.1| uroporphyrinogen-III synthase [Vibrio vulnificus YJ016]
Length = 260
Score = 159 bits (401), Expect = 2e-37, Method: Composition-based stats.
Identities = 103/244 (42%), Positives = 134/244 (54%), Gaps = 4/244 (1%)
Query: 1 MAVLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVS 60
MAVLVTRP E+GQ L +L +AGV A+ PL I + + LN L N LK D + AVS
Sbjct: 18 MAVLVTRPAEQGQALCQLLQQAGVPALQQPLIDIVANSSLNTLAND---LKQSDVIIAVS 74
Query: 61 KSAVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNA 120
+ AV A L A W + Y VGQ TA Y + T V+YPT + SE LLQL
Sbjct: 75 QHAVQCAEHILKAQQQNWPQNALYLAVGQKTAHYLSKVTHQDVNYPTVSD-SEHLLQLPE 133
Query: 121 MQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRAGIQ 180
++ K VLILRGNGGREL + QRGA+V E Y+RE I ++ ++ + G+
Sbjct: 134 FNRIAGKRVLILRGNGGRELIHQALSQRGADVRYCETYQRELIPFDAVSSLTLWRDQGVD 193
Query: 181 TIVVTSAEILTQLVDFVPQNEHNWLKSCQLITVSERIAHLAEALGWQNVVISPRADNQTL 240
T++VTSAE L L + WL +L+ SERIA +A LG+ V A N+ L
Sbjct: 194 TLIVTSAEQLDYLHAQMSDEGKFWLYQQRLLVPSERIAAIANRLGFTQVCNVGSASNKDL 253
Query: 241 LQTL 244
L L
Sbjct: 254 LAAL 257
>gi|27364542|ref|NP_760070.1| uroporphyrinogen-III synthetase [Vibrio vulnificus CMCP6]
gi|27360661|gb|AAO09597.1|AE016800_202 Uroporphyrinogen-III synthase [Vibrio vulnificus CMCP6]
Length = 243
Score = 159 bits (401), Expect = 2e-37, Method: Composition-based stats.
Identities = 103/244 (42%), Positives = 134/244 (54%), Gaps = 4/244 (1%)
Query: 1 MAVLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVS 60
MAVLVTRP E+GQ L +L +AGV A+ PL I + + LN L N LK D + AVS
Sbjct: 1 MAVLVTRPAEQGQALCQLLQQAGVPALQHPLIDIVANSSLNTLAND---LKQSDVIIAVS 57
Query: 61 KSAVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNA 120
+ AV A L A W + Y VGQ TA Y + T V+YPT + SE LLQL
Sbjct: 58 QHAVQCAEHILKAQQQNWPQNALYLAVGQKTAHYLSKVTHQDVNYPTVSD-SEHLLQLPV 116
Query: 121 MQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRAGIQ 180
++ K VLILRGNGGREL + QRGA+V E Y+RE I ++ ++ + G+
Sbjct: 117 FNRIAGKRVLILRGNGGRELIHQALSQRGADVRYCETYQRELIPFDAVSSLTLWRDQGVD 176
Query: 181 TIVVTSAEILTQLVDFVPQNEHNWLKSCQLITVSERIAHLAEALGWQNVVISPRADNQTL 240
T++VTSAE L L + WL +L+ SERIA +A LG+ V A N+ L
Sbjct: 177 TLIVTSAEQLDYLHAQMSDEGKFWLYQQRLLVPSERIAAIATQLGFTQVCNVGSASNKDL 236
Query: 241 LQTL 244
L L
Sbjct: 237 LAAL 240
>gi|59710672|ref|YP_203448.1| uroporphyrinogen-III synthase [Vibrio fischeri ES114]
gi|59478773|gb|AAW84560.1| uroporphyrinogen-III synthase [Vibrio fischeri ES114]
Length = 253
Score = 157 bits (396), Expect = 7e-37, Method: Composition-based stats.
Identities = 87/242 (35%), Positives = 131/242 (54%), Gaps = 1/242 (0%)
Query: 1 MAVLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVS 60
M +LVTRP++ Q L D L ++G AI PL I G EL++LP F L +GD++ AVS
Sbjct: 1 MTILVTRPEQESQALCDALNQSGHPAISHPLITIHPGNELSQLPRLFYSLNDGDFIIAVS 60
Query: 61 KSAVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNA 120
+ AV+ L W+ ++Y VGQ +AQ+ PVHYPT +SE LL L
Sbjct: 61 QHAVEHTQNYLKQLQLEWKQGVNYIAVGQKSAQHLKKYISDPVHYPT-HSDSEHLLALPV 119
Query: 121 MQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRAGIQ 180
+Q+ + K +ILRGNGGR+L + +V E Y+R+ I ++ + +T + +
Sbjct: 120 LQNATGKKAIILRGNGGRDLIYQVLNDLNVDVTYCEAYQRQAIAFDASIKTREWQEKNVN 179
Query: 181 TIVVTSAEILTQLVDFVPQNEHNWLKSCQLITVSERIAHLAEALGWQNVVISPRADNQTL 240
T++VTS E L+ + NW+ +L+ SERI A+ LG+Q++ A N L
Sbjct: 180 TLIVTSGEQLSFFTSQFTSTDLNWVLKLRLLVPSERINQFAKELGYQHIETVGGASNSDL 239
Query: 241 LQ 242
L
Sbjct: 240 LH 241
>gi|86148166|ref|ZP_01066464.1| uroporphyrinogen-III synthetase [Vibrio sp. MED222]
gi|85834013|gb|EAQ52173.1| uroporphyrinogen-III synthetase [Vibrio sp. MED222]
Length = 242
Score = 153 bits (387), Expect = 7e-36, Method: Composition-based stats.
Identities = 99/246 (40%), Positives = 127/246 (51%), Gaps = 8/246 (3%)
Query: 1 MAVLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVS 60
M VLVTRP GQ L LA G+ AIH PL RI ++L + L N D + AVS
Sbjct: 1 MTVLVTRPGSEGQSLCQQLADEGIQAIHHPLIRIVDNPHSSDLSTQ---LNNSDIIIAVS 57
Query: 61 KSAVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNA 120
AV A L+ T +W Y VGQ TA + ++ V+YP + SE LL+L
Sbjct: 58 HHAVTAAQNILSKTSSIWPTSPLYLGVGQKTAHVLSKVSKQKVNYPKVSD-SEHLLKLTE 116
Query: 121 MQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRRE--PIVYNNAEQTSICKRAG 178
+ + +K++LILRGNGGREL + RGA V E YRRE PI +N QT I K+
Sbjct: 117 LNGVDNKSILILRGNGGRELIRDSLLNRGAKVSYCETYRREYIPISDHNTYQTWINKKT- 175
Query: 179 IQTIVVTSAEILTQLVDFVPQNEHNWLKSCQLITVSERIAHLAEALGWQNVVISPRADNQ 238
+V+TS E L L P WL + L S+RI A+ LG+ NV + A NQ
Sbjct: 176 -SKVVITSQEQLEYLCSITPDEYLAWLSTRHLFVPSQRIVERAQQLGFSNVTNTHSATNQ 234
Query: 239 TLLQTL 244
LL L
Sbjct: 235 ILLAAL 240
>gi|84393565|ref|ZP_00992319.1| uroporphyrinogen-III synthetase [Vibrio splendidus 12B01]
gi|84375844|gb|EAP92737.1| uroporphyrinogen-III synthetase [Vibrio splendidus 12B01]
Length = 242
Score = 153 bits (386), Expect = 1e-35, Method: Composition-based stats.
Identities = 100/246 (40%), Positives = 128/246 (52%), Gaps = 8/246 (3%)
Query: 1 MAVLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVS 60
M VLVTRP GQ L LA G+ AIH PL RI ++L + L N D + AVS
Sbjct: 1 MTVLVTRPGSEGQSLCQQLADEGIQAIHHPLIRIVDNPHSSDLSTQ---LNNSDIIIAVS 57
Query: 61 KSAVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNA 120
AV A L+ T +W Y VGQ TA + ++ V+YP + SE LL+L
Sbjct: 58 HHAVTAAQNILSKTSSIWPTSPLYLGVGQKTAHVLSKVSKQKVNYPQVSD-SEHLLKLTE 116
Query: 121 MQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRRE--PIVYNNAEQTSICKRAG 178
+ + +K++LILRGNGGREL + RGA V E YRRE PI +N QT I K+
Sbjct: 117 LNGVDNKSILILRGNGGRELIRDSLLNRGAQVSYCETYRREYIPINDHNIYQTWINKKT- 175
Query: 179 IQTIVVTSAEILTQLVDFVPQNEHNWLKSCQLITVSERIAHLAEALGWQNVVISPRADNQ 238
+V+TS E L L P WL + QL S+RI A+ LG+ NV + A NQ
Sbjct: 176 -SKVVITSQEQLEYLCSITPDEYLAWLSTRQLFVPSQRIVERAQQLGFSNVTNTQSATNQ 234
Query: 239 TLLQTL 244
LL L
Sbjct: 235 ILLAAL 240
>gi|90414240|ref|ZP_01222220.1| hypothetical uroporphyrinogen III synthase [Photobacterium
profundum 3TCK]
gi|90324687|gb|EAS41228.1| hypothetical uroporphyrinogen III synthase [Photobacterium
profundum 3TCK]
Length = 251
Score = 152 bits (384), Expect = 2e-35, Method: Composition-based stats.
Identities = 86/244 (35%), Positives = 126/244 (51%)
Query: 1 MAVLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVS 60
M +L+TRP+ +L L AG+ AI PL I++G EL +L N+ LK D++ +S
Sbjct: 1 MTILITRPEPDCHELTQQLNAAGINAIAQPLLTIKAGNELPDLINQLKNLKTDDFLIVIS 60
Query: 61 KSAVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNA 120
AV+ A L + W ++HY VG TA T V P + +SEGLL L
Sbjct: 61 VHAVNLAHNYLMSQDVCWPKNVHYIAVGHKTAATLKRVTGQKVISPQMRCDSEGLLALPE 120
Query: 121 MQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRAGIQ 180
+ +++++ +LILRGNGGREL + +R A V E Y+R + N + +
Sbjct: 121 LANVTNRQILILRGNGGRELIHQTLTERNAKVSYCETYQRTWLALNGEALCRTWQAQNVS 180
Query: 181 TIVVTSAEILTQLVDFVPQNEHNWLKSCQLITVSERIAHLAEALGWQNVVISPRADNQTL 240
T+VVTS E L L VP+ W C L S+RIA+ A++LG++N A N+ L
Sbjct: 181 TLVVTSGEQLAYLTHLVPKQYLTWFFQCHLFVPSQRIANQAQSLGYKNFSTVGSASNKAL 240
Query: 241 LQTL 244
L
Sbjct: 241 FTFL 244
>gi|148978778|ref|ZP_01815158.1| uroporphyrinogen-III synthetase [Vibrionales bacterium SWAT-3]
gi|145962199|gb|EDK27483.1| uroporphyrinogen-III synthetase [Vibrionales bacterium SWAT-3]
Length = 242
Score = 152 bits (383), Expect = 2e-35, Method: Composition-based stats.
Identities = 102/246 (41%), Positives = 128/246 (52%), Gaps = 8/246 (3%)
Query: 1 MAVLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVS 60
M VLVTRP GQ L LA GV AIH PL RI + L +L N D + AVS
Sbjct: 1 MTVLVTRPGVEGQSLCQQLADEGVQAIHHPLIRIIDNPDTANLS---VRLNNSDIIIAVS 57
Query: 61 KSAVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNA 120
AV A L+ T +W Y VGQ TA + + V+YP + SE LL+L
Sbjct: 58 HHAVTAAQNILSKTSSIWPTSPLYLGVGQKTAHVLSKVCKQKVNYPQVSD-SEHLLKLAE 116
Query: 121 MQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRRE--PIVYNNAEQTSICKRAG 178
++D+++K++LILRGNGGREL + GA V E YRRE PI +N QT I K+
Sbjct: 117 LRDVNNKSILILRGNGGRELIRDSLLNLGAQVSYCETYRREYIPINDHNTYQTWINKKT- 175
Query: 179 IQTIVVTSAEILTQLVDFVPQNEHNWLKSCQLITVSERIAHLAEALGWQNVVISPRADNQ 238
+VVTS E L L P WL + L S+RIA A+ LG+ NV + A NQ
Sbjct: 176 -SKVVVTSQEQLEYLCSITPGEYSAWLSTRHLFVPSKRIAQRAQQLGFSNVTNTQSAANQ 234
Query: 239 TLLQTL 244
LL L
Sbjct: 235 ILLAAL 240
>gi|54310582|ref|YP_131602.1| hypothetical uroporphyrinogen III synthase [Photobacterium
profundum SS9]
gi|46915025|emb|CAG21800.1| hypothetical uroporphyrinogen III synthase [Photobacterium
profundum SS9]
Length = 248
Score = 150 bits (378), Expect = 8e-35, Method: Composition-based stats.
Identities = 85/241 (35%), Positives = 124/241 (51%)
Query: 4 LVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVSKSA 63
++TRP+ +L L AG+ AI PL I++G +L +L N+ KLK D++ +S A
Sbjct: 1 MITRPEPDCHELTQQLNAAGINAIAQPLLTIKAGNDLPDLINQLKKLKTDDFLIVISVHA 60
Query: 64 VDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNAMQD 123
V+ A L + W ++HY VG TA T V P + +SEGLL L + +
Sbjct: 61 VNLAHNYLMSQDVCWPKNVHYIAVGHKTATTLQRVTGQKVISPQTRCDSEGLLALPELAN 120
Query: 124 LSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRAGIQTIV 183
++D+ +LILRGNGGREL + +R A V E Y+R + N + + T+V
Sbjct: 121 VTDRQILILRGNGGRELIHQTLTERNAKVSYCETYQRTWLALNGEALCRTWQAQNVSTLV 180
Query: 184 VTSAEILTQLVDFVPQNEHNWLKSCQLITVSERIAHLAEALGWQNVVISPRADNQTLLQT 243
VTS E L L VP+ W C L S+RIA+ A+ LG++N A N+ L
Sbjct: 181 VTSGEQLAYLTHLVPKQYLTWFFQCHLFVPSQRIANQAKNLGYKNFSTVGSASNKALFTF 240
Query: 244 L 244
L
Sbjct: 241 L 241
>gi|28899763|ref|NP_799368.1| uroporphyrinogen-III synthetase [Vibrio parahaemolyticus RIMD
2210633]
gi|153838748|ref|ZP_01991415.1| uroporphyrinogen-III synthase [Vibrio parahaemolyticus AQ3810]
gi|28808015|dbj|BAC61252.1| uroporphyrinogen-III synthase [Vibrio parahaemolyticus RIMD
2210633]
gi|149747834|gb|EDM58718.1| uroporphyrinogen-III synthase [Vibrio parahaemolyticus AQ3810]
Length = 242
Score = 148 bits (373), Expect = 4e-34, Method: Composition-based stats.
Identities = 98/244 (40%), Positives = 128/244 (52%), Gaps = 4/244 (1%)
Query: 1 MAVLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVS 60
MAVLVTRP E+G L +L + G+ A H PL I + L L V AVS
Sbjct: 1 MAVLVTRPGEQGSALCSLLERHGISAHHHPLIDIVADLTDTHLT---THLHQAQIVIAVS 57
Query: 61 KSAVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNA 120
+ AV A + LT+ G W Y VGQ TA Y + T+ VHYP + SE LL+L A
Sbjct: 58 RHAVQCAQQILTSNGASWPKQAVYLAVGQKTAHYLSKCTQQKVHYPEVSD-SEHLLRLPA 116
Query: 121 MQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRAGIQ 180
+Q++ + VLILRGNGGREL + +RGA V E Y+RE I+++ S+ K I
Sbjct: 117 LQNVEQQQVLILRGNGGRELIKDALVRRGAKVHYSETYKREFILFDPVSCVSLWKTLQIN 176
Query: 181 TIVVTSAEILTQLVDFVPQNEHNWLKSCQLITVSERIAHLAEALGWQNVVISPRADNQTL 240
IVVTS E L L + + WL +L S+RIA +A G+ V + A NQ L
Sbjct: 177 QIVVTSGEQLDYLCSQLTSEQLAWLNQQELYIPSQRIADIAIQRGFTRVRCTGSASNQEL 236
Query: 241 LQTL 244
L L
Sbjct: 237 LAAL 240
>gi|90581041|ref|ZP_01236841.1| hypothetical uroporphyrinogen III synthase [Vibrio angustum S14]
gi|90437737|gb|EAS62928.1| hypothetical uroporphyrinogen III synthase [Vibrio angustum S14]
Length = 248
Score = 145 bits (366), Expect = 2e-33, Method: Composition-based stats.
Identities = 88/244 (36%), Positives = 125/244 (51%)
Query: 1 MAVLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVS 60
M VL+TRP QL + L A + AI PL +++G L+ L + LK GDY+ AVS
Sbjct: 1 MTVLITRPAPDCYQLAEQLNAAAISAIAQPLLTLKAGDGLSSLLLQINALKAGDYIIAVS 60
Query: 61 KSAVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNA 120
AV FA L + G W ++HY VG TA T + V P + +SEGLL L
Sbjct: 61 HHAVTFAHDYLVSQGAAWPKNVHYVAVGHKTAATLTKLSGQRVLSPEHRCDSEGLLALPE 120
Query: 121 MQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRAGIQ 180
+ ++D+ +LILRGNGGREL + R A V E Y+R + + + + + +
Sbjct: 121 LAKVTDRNILILRGNGGRELIHQALTARHAVVNYCETYQRCWLDLDGEKLVAQWQHQQLD 180
Query: 181 TIVVTSAEILTQLVDFVPQNEHNWLKSCQLITVSERIAHLAEALGWQNVVISPRADNQTL 240
T+V+TSAE L L +P W +C L+ S+R+A A LG+ N+ A N L
Sbjct: 181 TLVITSAEQLVFLTTRIPTQHLTWFLNCHLLVPSQRVAEQATTLGFMNISTVGSASNHAL 240
Query: 241 LQTL 244
L
Sbjct: 241 FTFL 244
>gi|2495182|sp|Q59683|HEM4_PROMI Uroporphyrinogen-III synthase (UROS) (Uroporphyrinogen-III
cosynthetase) (Hydroxymethylbilane hydrolyase
[cyclizing])
gi|726358|gb|AAC44328.1| uroporphyrinogen III synthase
Length = 199
Score = 144 bits (364), Expect = 3e-33, Method: Composition-based stats.
Identities = 83/194 (42%), Positives = 112/194 (57%)
Query: 1 MAVLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVS 60
M++L+TRP G+QL L AG A H PL I +G EL+ L NK KL GDY+F +S
Sbjct: 1 MSILITRPSPAGEQLTQRLIDAGKHAFHAPLIEIAAGKELSILENKLNKLSTGDYLFLLS 60
Query: 61 KSAVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNA 120
K+AV +A L W L Y+ +GQ TA+ F T + YP E SE LL L++
Sbjct: 61 KNAVWYANWQLNQLQQSWPDTLFYYGIGQSTAEEFQQLTAHSIRYPEFGETSEDLLALSS 120
Query: 121 MQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRAGIQ 180
+Q + +K VL+LRGNGGREL A +QRGA V+ ECY+R I Y + E K A ++
Sbjct: 121 LQQIENKRVLLLRGNGGRELLATTLRQRGAIVDECECYQRLFIDYVSEEFALKWKNAQVE 180
Query: 181 TIVVTSAEILTQLV 194
+ E+L QL+
Sbjct: 181 YLCGHQCEMLQQLL 194
>gi|116184836|ref|ZP_01474760.1| hypothetical protein VEx2w_02002625 [Vibrio sp. Ex25]
gi|151937351|gb|EDN56213.1| uroporphyrinogen-III synthase [Vibrio sp. Ex25]
Length = 242
Score = 144 bits (362), Expect = 6e-33, Method: Composition-based stats.
Identities = 94/244 (38%), Positives = 125/244 (51%), Gaps = 4/244 (1%)
Query: 1 MAVLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVS 60
MAVLVTRP E+G L +L + G+ A H PL I + L L V AVS
Sbjct: 1 MAVLVTRPGEQGNALCSLLERHGISAYHHPLIDIVADLTDTHLSKH---LHQAQIVIAVS 57
Query: 61 KSAVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNA 120
+ AV A + L + G W Y VGQ TA Y + T+ VHYP + SE LL+L
Sbjct: 58 RHAVQCAQQILASNGMSWPKQAIYLAVGQKTAHYLSKCTQQKVHYPQVSD-SEHLLRLPE 116
Query: 121 MQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRAGIQ 180
+ +++ + VLILRGNGGREL + +RGA V E Y+RE I ++ S+ K I
Sbjct: 117 LNNVAQQQVLILRGNGGRELIKDALVRRGAKVHYSETYKREFIPFDPVSCVSLWKTLQID 176
Query: 181 TIVVTSAEILTQLVDFVPQNEHNWLKSCQLITVSERIAHLAEALGWQNVVISPRADNQTL 240
I+VTS E L L + + WL +L S+RIA +A G+ V + A NQ L
Sbjct: 177 QIIVTSGEQLDYLCSQLTSEQLTWLNQQELYIPSQRIADIALQRGFTRVRCTGSASNQEL 236
Query: 241 LQTL 244
L L
Sbjct: 237 LAAL 240
>gi|150422138|gb|EDN14104.1| uroporphyrinogen-III synthase [Vibrio cholerae AM-19226]
Length = 260
Score = 143 bits (360), Expect = 1e-32, Method: Composition-based stats.
Identities = 92/248 (37%), Positives = 136/248 (54%), Gaps = 10/248 (4%)
Query: 1 MAVLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVS 60
M VLVTRPDE+G +L +L + G+ A+H PL I + +L L + D + AVS
Sbjct: 6 MTVLVTRPDEQGTELCQLLHQQGIPALHHPLIAISASPQLTALAEDLSSF---DIIIAVS 62
Query: 61 KSAVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNA 120
+ AV F+ + L W ++ Y VGQ TA F+ + V YP + SE LL L+
Sbjct: 63 QHAVIFSDQFLQHRRICWPNNAIYLAVGQKTAHVFSKACQQSVDYPEISD-SEHLLALSM 121
Query: 121 MQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRAGIQ 180
++D++ K VLILRGNGGREL +RGA V E Y R + AE + A +
Sbjct: 122 LRDVAGKKVLILRGNGGRELIYSTLVERGATVRYQEAYCRHERPFAAAECVQKWQLAKVD 181
Query: 181 TIVVTSAEILTQLVDFVPQNEHN---WLKSCQLITVSERIAHLAEALGWQNVVISPRADN 237
++V+TS+E QL F+ Q E + W++ L+ S+RIA LA LG+ +V++ A N
Sbjct: 182 SLVITSSE---QLAFFIRQFETSHLPWVQQLTLLVPSQRIATLAHQLGFHRIVVTLSAAN 238
Query: 238 QTLLQTLL 245
+ L+ L+
Sbjct: 239 RDLVAALM 246
>gi|153803405|ref|ZP_01957991.1| uroporphyrinogen-III synthase [Vibrio cholerae MZO-3]
gi|124121062|gb|EAY39805.1| uroporphyrinogen-III synthase [Vibrio cholerae MZO-3]
Length = 260
Score = 143 bits (360), Expect = 1e-32, Method: Composition-based stats.
Identities = 92/248 (37%), Positives = 136/248 (54%), Gaps = 10/248 (4%)
Query: 1 MAVLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVS 60
M VLVTRPDE+G +L +L + G+ A+H PL I + +L L + D + AVS
Sbjct: 6 MTVLVTRPDEQGAELCQLLHQQGIPALHHPLIAISASPQLAALAEDLSSF---DIIIAVS 62
Query: 61 KSAVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNA 120
+ AV F+ + L W ++ Y VGQ TA F+ + V YP + SE LL L+
Sbjct: 63 QHAVIFSDQFLQHRRICWPNNAIYLAVGQKTAHVFSKACQQSVDYPEISD-SEHLLALSM 121
Query: 121 MQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRAGIQ 180
++D++ K VLILRGNGGREL +RGA V E Y R + AE + A +
Sbjct: 122 LRDVAGKKVLILRGNGGRELIYSTLVERGATVRYQEAYCRHERPFTAAECVQKWQLAKVD 181
Query: 181 TIVVTSAEILTQLVDFVPQNEHN---WLKSCQLITVSERIAHLAEALGWQNVVISPRADN 237
++V+TS+E QL F+ Q E + W++ L+ S+RIA LA LG+ +V++ A N
Sbjct: 182 SLVITSSE---QLAFFIRQFETSHLPWVQQLTLLVPSQRIATLAHQLGFHRIVVTLSAAN 238
Query: 238 QTLLQTLL 245
+ L+ L+
Sbjct: 239 RDLVAALM 246
>gi|125620869|gb|EAZ49222.1| uroporphyrinogen-III synthase [Vibrio cholerae V51]
Length = 260
Score = 142 bits (359), Expect = 1e-32, Method: Composition-based stats.
Identities = 92/248 (37%), Positives = 136/248 (54%), Gaps = 10/248 (4%)
Query: 1 MAVLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVS 60
M VLVTRPDE+G +L +L + G+ A+H PL I + +L L + D + AVS
Sbjct: 6 MTVLVTRPDEQGAELCQLLHQQGIPALHHPLLAISASPQLAALAEDLSSF---DIIIAVS 62
Query: 61 KSAVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNA 120
+ AV F+ + L W ++ Y VGQ TA F+ + V YP + SE LL L+
Sbjct: 63 QHAVIFSDQFLQHRRICWPNNAIYLAVGQKTAHVFSKACQQSVDYPEISD-SEHLLALSM 121
Query: 121 MQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRAGIQ 180
++D++ K VLILRGNGGREL +RGA V E Y R + AE + A +
Sbjct: 122 LRDVAGKKVLILRGNGGRELIYSTLVERGATVRYQEAYCRHERPFAAAECVQKWQLAKVD 181
Query: 181 TIVVTSAEILTQLVDFVPQNEHN---WLKSCQLITVSERIAHLAEALGWQNVVISPRADN 237
++V+TS+E QL F+ Q E + W++ L+ S+RIA LA LG+ +V++ A N
Sbjct: 182 SLVITSSE---QLAFFIRQFETSHLPWVQQLTLLVPSQRIATLAHQLGFHRIVVTLSAAN 238
Query: 238 QTLLQTLL 245
+ L+ L+
Sbjct: 239 RDLVAALM 246
>gi|153826275|ref|ZP_01978942.1| uroporphyrinogen-III synthase [Vibrio cholerae MZO-2]
gi|153830630|ref|ZP_01983297.1| uroporphyrinogen-III synthase [Vibrio cholerae 623-39]
gi|148873902|gb|EDL72037.1| uroporphyrinogen-III synthase [Vibrio cholerae 623-39]
gi|149739943|gb|EDM54122.1| uroporphyrinogen-III synthase [Vibrio cholerae MZO-2]
Length = 260
Score = 142 bits (358), Expect = 2e-32, Method: Composition-based stats.
Identities = 92/248 (37%), Positives = 136/248 (54%), Gaps = 10/248 (4%)
Query: 1 MAVLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVS 60
M VLVTRPDE+G +L +L + G+ A+H PL I + +L L + D + AVS
Sbjct: 6 MTVLVTRPDEQGAELCQLLHQQGIPALHHPLIAISASPQLAALAEDLSSF---DIIIAVS 62
Query: 61 KSAVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNA 120
+ AV F+ + L W ++ Y VGQ TA F+ + V YP + SE LL L+
Sbjct: 63 QHAVIFSDQFLQHRRICWPNNAIYLAVGQKTAHVFSKACQQSVDYPEISD-SEHLLALSM 121
Query: 121 MQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRAGIQ 180
++D++ K VLILRGNGGREL +RGA V E Y R + AE + A +
Sbjct: 122 LRDVAGKKVLILRGNGGRELIYSTLVERGATVRYQEAYCRHERPFAAAECVQKWQLAKVD 181
Query: 181 TIVVTSAEILTQLVDFVPQNEHN---WLKSCQLITVSERIAHLAEALGWQNVVISPRADN 237
++V+TS+E QL F+ Q E + W++ L+ S+RIA LA LG+ +V++ A N
Sbjct: 182 SLVITSSE---QLAFFIRQFETSHLPWVQQLTLLVPSQRIATLAHQLGFHRIVVTLSAAN 238
Query: 238 QTLLQTLL 245
+ L+ L+
Sbjct: 239 RDLVAALM 246
>gi|89074444|ref|ZP_01160921.1| hypothetical uroporphyrinogen III synthase [Photobacterium sp.
SKA34]
gi|89049732|gb|EAR55282.1| hypothetical uroporphyrinogen III synthase [Photobacterium sp.
SKA34]
Length = 248
Score = 142 bits (358), Expect = 2e-32, Method: Composition-based stats.
Identities = 84/244 (34%), Positives = 124/244 (50%)
Query: 1 MAVLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVS 60
M VL+TRP +L + L A + AI PL +++G L+ L + LK GDY+ VS
Sbjct: 1 MTVLITRPAPDCYRLAEQLNAAAISAIAQPLLTLKAGDGLSSLLRQINALKAGDYIITVS 60
Query: 61 KSAVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNA 120
+V FA L + G W ++HY +G TA T + V P + +SEGLL L
Sbjct: 61 HHSVTFAHDYLISQGAAWPKNVHYIAIGHKTAATLTKLSGQRVLSPEHRCDSEGLLALPE 120
Query: 121 MQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRAGIQ 180
+ ++D+ +LILRGNGGREL + R A V E Y+R + + + + + +
Sbjct: 121 LAHITDRNILILRGNGGRELIHQALTARHAVVNYCETYQRCWLDLDGEKLVAQWQHQQLD 180
Query: 181 TIVVTSAEILTQLVDFVPQNEHNWLKSCQLITVSERIAHLAEALGWQNVVISPRADNQTL 240
T+V+TSAE L L +P W +C L+ S+R+A A LG+ N+ A N L
Sbjct: 181 TLVITSAEQLVFLTTRIPTQHLTWFLNCHLLVPSQRVAEQATTLGFMNISTVGSASNHAL 240
Query: 241 LQTL 244
L
Sbjct: 241 FTFL 244
>gi|116188281|ref|ZP_01478061.1| hypothetical protein VchoM_02002811 [Vibrio cholerae MO10]
gi|116220348|ref|ZP_01485785.1| hypothetical protein VchoV5_02001616 [Vibrio cholerae V51]
Length = 255
Score = 142 bits (358), Expect = 2e-32, Method: Composition-based stats.
Identities = 92/248 (37%), Positives = 136/248 (54%), Gaps = 10/248 (4%)
Query: 1 MAVLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVS 60
M VLVTRPDE+G +L +L + G+ A+H PL I + +L L + D + AVS
Sbjct: 1 MTVLVTRPDEQGAELCQLLHQQGIPALHHPLLAISASPQLAALAEDLSSF---DIIIAVS 57
Query: 61 KSAVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNA 120
+ AV F+ + L W ++ Y VGQ TA F+ + V YP + SE LL L+
Sbjct: 58 QHAVIFSDQFLQHRRICWPNNAIYLAVGQKTAHVFSKACQQSVDYPEISD-SEHLLALSM 116
Query: 121 MQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRAGIQ 180
++D++ K VLILRGNGGREL +RGA V E Y R + AE + A +
Sbjct: 117 LRDVAGKKVLILRGNGGRELIYSTLVERGATVRYQEAYCRHERPFAAAECVQKWQLAKVD 176
Query: 181 TIVVTSAEILTQLVDFVPQNEHN---WLKSCQLITVSERIAHLAEALGWQNVVISPRADN 237
++V+TS+E QL F+ Q E + W++ L+ S+RIA LA LG+ +V++ A N
Sbjct: 177 SLVITSSE---QLAFFIRQFETSHLPWVQQLTLLVPSQRIATLAHQLGFHRIVVTLSAAN 233
Query: 238 QTLLQTLL 245
+ L+ L+
Sbjct: 234 RDLVAALM 241
>gi|15640151|ref|NP_229778.1| uroporphyrinogen-III synthetase [Vibrio cholerae O1 biovar eltor
str. N16961]
gi|121587740|ref|ZP_01677501.1| uroporphyrinogen-III synthase [Vibrio cholerae 2740-80]
gi|121728311|ref|ZP_01681342.1| uroporphyrinogen-III synthase [Vibrio cholerae V52]
gi|147674713|ref|YP_001218299.1| uroporphyrinogen-III synthase [Vibrio cholerae O395]
gi|153223855|ref|ZP_01954092.1| uroporphyrinogen-III synthase [Vibrio cholerae MAK 757]
gi|153818936|ref|ZP_01971603.1| uroporphyrinogen-III synthase [Vibrio cholerae NCTC 8457]
gi|153822317|ref|ZP_01974984.1| uroporphyrinogen-III synthase [Vibrio cholerae B33]
gi|9654519|gb|AAF93297.1| uroporphyrinogen-III synthase [Vibrio cholerae O1 biovar eltor str.
N16961]
gi|121548039|gb|EAX58117.1| uroporphyrinogen-III synthase [Vibrio cholerae 2740-80]
gi|121629441|gb|EAX61870.1| uroporphyrinogen-III synthase [Vibrio cholerae V52]
gi|124117966|gb|EAY36709.1| uroporphyrinogen-III synthase [Vibrio cholerae MAK 757]
gi|126510498|gb|EAZ73092.1| uroporphyrinogen-III synthase [Vibrio cholerae NCTC 8457]
gi|126520143|gb|EAZ77366.1| uroporphyrinogen-III synthase [Vibrio cholerae B33]
gi|146316596|gb|ABQ21135.1| uroporphyrinogen-III synthase [Vibrio cholerae O395]
Length = 260
Score = 142 bits (358), Expect = 2e-32, Method: Composition-based stats.
Identities = 92/248 (37%), Positives = 136/248 (54%), Gaps = 10/248 (4%)
Query: 1 MAVLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVS 60
M VLVTRPDE+G +L +L + G+ A+H PL I + +L L + D + AVS
Sbjct: 6 MTVLVTRPDEQGAELCQLLHQQGIPALHHPLLAISASPQLAALAEDLSSF---DIIIAVS 62
Query: 61 KSAVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNA 120
+ AV F+ + L W ++ Y VGQ TA F+ + V YP + SE LL L+
Sbjct: 63 QHAVIFSDQFLQHRRICWPNNAIYLAVGQKTAHVFSKACQQSVDYPEISD-SEHLLALSM 121
Query: 121 MQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRAGIQ 180
++D++ K VLILRGNGGREL +RGA V E Y R + AE + A +
Sbjct: 122 LRDVAGKKVLILRGNGGRELIYSTLVERGATVRYQEAYCRHERPFAAAECVQKWQLAKVD 181
Query: 181 TIVVTSAEILTQLVDFVPQNEHN---WLKSCQLITVSERIAHLAEALGWQNVVISPRADN 237
++V+TS+E QL F+ Q E + W++ L+ S+RIA LA LG+ +V++ A N
Sbjct: 182 SLVITSSE---QLAFFIRQFETSHLPWVQQLTLLVPSQRIATLAHQLGFHRIVVTLSAAN 238
Query: 238 QTLLQTLL 245
+ L+ L+
Sbjct: 239 RDLVAALM 246
>gi|153214847|ref|ZP_01949655.1| uroporphyrinogen-III synthase [Vibrio cholerae 1587]
gi|124115090|gb|EAY33910.1| uroporphyrinogen-III synthase [Vibrio cholerae 1587]
Length = 255
Score = 142 bits (358), Expect = 2e-32, Method: Composition-based stats.
Identities = 92/248 (37%), Positives = 136/248 (54%), Gaps = 10/248 (4%)
Query: 1 MAVLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVS 60
M VLVTRPDE+G +L +L + G+ A+H PL I + +L L + D + AVS
Sbjct: 1 MTVLVTRPDEQGAELCQLLHQQGIPALHHPLIAISASPQLAALAEDLSSF---DIIIAVS 57
Query: 61 KSAVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNA 120
+ AV F+ + L W ++ Y VGQ TA F+ + V YP + SE LL L+
Sbjct: 58 QHAVIFSDQFLQHRRICWPNNAIYLAVGQKTAHVFSKACQQSVDYPEISD-SEHLLALSM 116
Query: 121 MQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRAGIQ 180
++D++ K VLILRGNGGREL +RGA V E Y R + AE + A +
Sbjct: 117 LRDVAGKKVLILRGNGGRELIYSTLVERGATVRYQEAYCRHERPFAAAECVQKWQLAKVD 176
Query: 181 TIVVTSAEILTQLVDFVPQNEHN---WLKSCQLITVSERIAHLAEALGWQNVVISPRADN 237
++V+TS+E QL F+ Q E + W++ L+ S+RIA LA LG+ +V++ A N
Sbjct: 177 SLVITSSE---QLAFFIRQFETSHLPWVQQLTLLVPSQRIATLAHQLGFHRIVVTLSAAN 233
Query: 238 QTLLQTLL 245
+ L+ L+
Sbjct: 234 RDLVAALM 241
>gi|91227535|ref|ZP_01261872.1| uroporphyrinogen-III synthetase [Vibrio alginolyticus 12G01]
gi|91188559|gb|EAS74851.1| uroporphyrinogen-III synthetase [Vibrio alginolyticus 12G01]
Length = 242
Score = 142 bits (357), Expect = 2e-32, Method: Composition-based stats.
Identities = 93/244 (38%), Positives = 124/244 (50%), Gaps = 4/244 (1%)
Query: 1 MAVLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVS 60
MAVLVTRP E+G L +L + G+ A H PL I + L L V AVS
Sbjct: 1 MAVLVTRPGEQGNALCSLLERHGISAYHHPLIDIVADLTDTHLSKH---LHQAQIVIAVS 57
Query: 61 KSAVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNA 120
+ AV A + L + G W Y VGQ TA Y + T+ VHYP + SE LL+L
Sbjct: 58 RHAVQCAQQILASNGMSWPKQAIYLAVGQKTAHYLSKCTQQKVHYPQVSD-SEHLLRLPE 116
Query: 121 MQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRAGIQ 180
+ +++ + VLILRGNGGREL + + GA V E Y+RE I ++ S+ K I
Sbjct: 117 LNNVAQQQVLILRGNGGRELIKDALVRHGAKVHYSETYKREFIPFDPVSCISLWKNLQIN 176
Query: 181 TIVVTSAEILTQLVDFVPQNEHNWLKSCQLITVSERIAHLAEALGWQNVVISPRADNQTL 240
I+VTS E L L + + WL +L S+RIA +A G+ V + A NQ L
Sbjct: 177 QIIVTSGEQLDYLCSQLTSEQLTWLNQQELYIPSQRIADIAIQRGFTRVRCTGSASNQEL 236
Query: 241 LQTL 244
L L
Sbjct: 237 LAAL 240
>gi|153835502|ref|ZP_01988169.1| uroporphyrinogen-III synthase [Vibrio harveyi HY01]
gi|148867928|gb|EDL67138.1| uroporphyrinogen-III synthase [Vibrio harveyi HY01]
Length = 242
Score = 141 bits (356), Expect = 3e-32, Method: Composition-based stats.
Identities = 95/244 (38%), Positives = 128/244 (52%), Gaps = 4/244 (1%)
Query: 1 MAVLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVS 60
MAVLVTRP E+G L +L + G AIH PL I + +L +K+ ++ + AVS
Sbjct: 1 MAVLVTRPGEQGAALCSLLERHGKTAIHHPLIDIVADLSDTQL-SKY--IETAQIIIAVS 57
Query: 61 KSAVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNA 120
+ AV A + L W Y VGQ TA Y + T+ VHYP + SE LLQL
Sbjct: 58 QHAVQCAEQILQNHAKSWSKQAIYLAVGQKTAHYLSKCTQQKVHYPQVSD-SEHLLQLPE 116
Query: 121 MQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRAGIQ 180
+ ++ +TVLILRGNGGREL + +RGA V E Y+RE I ++ S+ K I
Sbjct: 117 LNNVEKQTVLILRGNGGRELIKDALVRRGAKVHYSETYKREFIPFDPVSCVSLWKTQQID 176
Query: 181 TIVVTSAEILTQLVDFVPQNEHNWLKSCQLITVSERIAHLAEALGWQNVVISPRADNQTL 240
I+VTS E L L + + WL +L S+RIA +A G+ V + A NQ L
Sbjct: 177 QIIVTSGEQLDYLCSQLTSEQLTWLNQQELYIPSQRIADIAIQRGFTQVRCTGSASNQEL 236
Query: 241 LQTL 244
L L
Sbjct: 237 LAAL 240
>gi|156972663|ref|YP_001443570.1| hypothetical protein VIBHAR_00315 [Vibrio harveyi ATCC BAA-1116]
gi|156524257|gb|ABU69343.1| hypothetical protein VIBHAR_00315 [Vibrio harveyi ATCC BAA-1116]
Length = 242
Score = 141 bits (356), Expect = 3e-32, Method: Composition-based stats.
Identities = 95/244 (38%), Positives = 128/244 (52%), Gaps = 4/244 (1%)
Query: 1 MAVLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVS 60
MAVLVTRP E+G L +L + G AIH PL I + +L +K+ ++ + AVS
Sbjct: 1 MAVLVTRPGEQGAALCSLLERHGKTAIHHPLIDIVADLSDTQL-SKY--IETAQIIIAVS 57
Query: 61 KSAVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNA 120
+ AV A + L W Y VGQ TA Y + T+ VHYP + SE LLQL
Sbjct: 58 QHAVQCAEQILQNHAKSWSKQAVYLAVGQKTAHYLSKCTQQKVHYPQVSD-SEHLLQLPE 116
Query: 121 MQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRAGIQ 180
+ ++ +TVLILRGNGGREL + +RGA V E Y+RE I ++ S+ K I
Sbjct: 117 LNNVEKQTVLILRGNGGRELIKDALVRRGAKVHYSETYKREFIPFDPVSCVSLWKTQQID 176
Query: 181 TIVVTSAEILTQLVDFVPQNEHNWLKSCQLITVSERIAHLAEALGWQNVVISPRADNQTL 240
I+VTS E L L + + WL +L S+RIA +A G+ V + A NQ L
Sbjct: 177 QIIVTSGEQLDYLCSQLTSEQLTWLNQQELYIPSQRIADIAIQRGFTQVRCTGSASNQEL 236
Query: 241 LQTL 244
L L
Sbjct: 237 LAAL 240
>gi|116215617|ref|ZP_01481589.1| hypothetical protein VchoR_02002514 [Vibrio cholerae RC385]
Length = 255
Score = 140 bits (354), Expect = 5e-32, Method: Composition-based stats.
Identities = 92/248 (37%), Positives = 135/248 (54%), Gaps = 10/248 (4%)
Query: 1 MAVLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVS 60
M VLVTRPDE+G +L L + G+ A+H PL I + +L L + D + AVS
Sbjct: 1 MTVLVTRPDEQGAELCQRLHQQGISALHHPLLAITASPQLAALAEDLSSF---DIIIAVS 57
Query: 61 KSAVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNA 120
+ AV F+ + L W ++ Y VGQ TA F+ + V YP + SE LL L+
Sbjct: 58 QHAVIFSDQFLQHRRICWPNNAIYLAVGQKTAHVFSKACQQSVDYPEISD-SEHLLALSM 116
Query: 121 MQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRAGIQ 180
++D++ K VLILRGNGGREL +RGA V E Y R + AE + A +
Sbjct: 117 LRDVAGKKVLILRGNGGRELIYSTLVERGATVRYQEAYCRHERPFAAAECVQKWQLAKVD 176
Query: 181 TIVVTSAEILTQLVDFVPQNEHN---WLKSCQLITVSERIAHLAEALGWQNVVISPRADN 237
++V+TS+E QL F+ Q E + W++ L+ S+RIA LA LG+ +V++ A N
Sbjct: 177 SLVITSSE---QLAFFIRQFETSHLPWVQQLTLLVPSQRIATLAHQLGFHRIVVTLSAAN 233
Query: 238 QTLLQTLL 245
+ L+ L+
Sbjct: 234 RDLVAALM 241
>gi|149908496|ref|ZP_01897158.1| hypothetical uroporphyrinogen III synthase [Moritella sp. PE36]
gi|149808330|gb|EDM68267.1| hypothetical uroporphyrinogen III synthase [Moritella sp. PE36]
Length = 255
Score = 134 bits (338), Expect = 4e-30, Method: Composition-based stats.
Identities = 79/243 (32%), Positives = 126/243 (51%), Gaps = 1/243 (0%)
Query: 4 LVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVSKSA 63
L+TRP +G+QL + A A+ P I +G + ++ + A+L+ DY+ A+S +A
Sbjct: 6 LITRPRVKGEQLARQIEAADGAALCCPFIDISAGQQFTKVSSLLAELQPDDYIIAISDNA 65
Query: 64 VDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNAMQD 123
V++A +L W ++Y VG TA + P + SEG+L+L A
Sbjct: 66 VNYANTSLINANRTWPQQINYIAVGPTTALSWQKYGINHAQIPDTHD-SEGVLKLLANAS 124
Query: 124 LSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRAGIQTIV 183
+ K ++ILRGNGGRE AE +R ANV E Y+R Y+ + ++ I +++
Sbjct: 125 VEHKKIVILRGNGGRETLAEDLTKRTANVTYCEVYQRTAPDYDPDMLINKWQQFAINSVI 184
Query: 184 VTSAEILTQLVDFVPQNEHNWLKSCQLITVSERIAHLAEALGWQNVVISPRADNQTLLQT 243
+TS EIL L+ +P W+ + I S+RIA LA LG ++V I+ A N +L
Sbjct: 185 ITSGEILGNLIKTIPYTALPWILNLHFIVPSQRIAALAHTLGIEHVTIATGASNNSLFNA 244
Query: 244 LLQ 246
+ Q
Sbjct: 245 IKQ 247
>gi|149191475|ref|ZP_01869724.1| uroporphyrinogen-III synthetase [Vibrio shilonii AK1]
gi|148834663|gb|EDL51651.1| uroporphyrinogen-III synthetase [Vibrio shilonii AK1]
Length = 252
Score = 134 bits (336), Expect = 7e-30, Method: Composition-based stats.
Identities = 93/246 (37%), Positives = 135/246 (54%), Gaps = 9/246 (3%)
Query: 1 MAVLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVS 60
M VLVTRP+ +G++L +++ K G +A+H PL I+ +L ++ L+ D + AVS
Sbjct: 1 MRVLVTRPENQGEELCNLIEKMGGIALHQPLIDIQDNLQLCLDDDQ---LQRSDIIIAVS 57
Query: 61 KSAVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNA 120
+ AV L+ Y VGQ TA + ++ V+YPT + SE LL L
Sbjct: 58 QYAVYAFHHILSHQQLSLPDSCIYLGVGQKTAHELSKLSQQNVNYPTVSD-SEHLLALPE 116
Query: 121 MQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRRE--PIVYNNAEQTSICKRAG 178
+ ++S K V+ILRGNGGREL +Q GA+V+ +E Y+R P+ + +Q + G
Sbjct: 117 LANVSGKHVIILRGNGGRELIYDQLCALGADVQYLETYQRRYLPLKIDAIKQ---WRSMG 173
Query: 179 IQTIVVTSAEILTQLVDFVPQNEHNWLKSCQLITVSERIAHLAEALGWQNVVISPRADNQ 238
I T+VVTS E L L+ V + E NWL QL+ SERIA LA G+ NV + A N
Sbjct: 174 IDTLVVTSGEQLEFLLSQVSEPELNWLTQQQLLVPSERIATLAMTKGFNNVTNTQGASNS 233
Query: 239 TLLQTL 244
T+ L
Sbjct: 234 TIFAAL 239
>gi|114561626|ref|YP_749139.1| Uroporphyrinogen III synthase HEM4 [Shewanella frigidimarina NCIMB
400]
gi|114332919|gb|ABI70301.1| Uroporphyrinogen III synthase HEM4 [Shewanella frigidimarina NCIMB
400]
Length = 239
Score = 133 bits (334), Expect = 1e-29, Method: Composition-based stats.
Identities = 89/245 (36%), Positives = 128/245 (52%), Gaps = 9/245 (3%)
Query: 1 MAVLVTRPDERGQQLVDMLAKAGVVAIHLPLFRI-ESGAELNELPNKFAKLKNGDYVFAV 59
M VL+TRP R Q + + L+ V + PL + E+ +LN L N D + +
Sbjct: 1 MKVLLTRPQGRNQAMEEQLSLRDVAYLVTPLLSVVETTEQLNP-----THLNNTDNLLFI 55
Query: 60 SKSAVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLN 119
S +AVDFA + L + YF VGQ TA P ++SEGLL L
Sbjct: 56 SSNAVDFAAQKLQQQ---FPTHCRYFAVGQATADSLAQYNINAFTSPEHSQDSEGLLSLA 112
Query: 120 AMQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRAGI 179
+QD+ ++ +I+RG GGRE AEQ Q RGANV + Y+R + T K GI
Sbjct: 113 QLQDVDKQSFIIVRGLGGRETLAEQLQLRGANVNYWQVYQRAIPNLDGKAITQQWKSFGI 172
Query: 180 QTIVVTSAEILTQLVDFVPQNEHNWLKSCQLITVSERIAHLAEALGWQNVVISPRADNQT 239
TIVVTS EIL+ LV+ VP+ WL++C +I S R+ A+A+G ++ + A+ Q
Sbjct: 173 DTIVVTSGEILSNLVELVPKELFAWLRACHIIVPSNRVELQAKAMGLSHISNANGANTQA 232
Query: 240 LLQTL 244
+L +L
Sbjct: 233 ILASL 237
>gi|145300737|ref|YP_001143578.1| uroporphyrinogen-III synthase [Aeromonas salmonicida subsp.
salmonicida A449]
gi|142853509|gb|ABO91830.1| uroporphyrinogen-III synthase [Aeromonas salmonicida subsp.
salmonicida A449]
Length = 244
Score = 133 bits (334), Expect = 1e-29, Method: Composition-based stats.
Identities = 90/244 (36%), Positives = 123/244 (50%), Gaps = 6/244 (2%)
Query: 1 MAVLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVS 60
M LV RP + +LV +L + G + PL +G+EL LP L D V AVS
Sbjct: 1 MIPLVVRPAAQAAELVQLLRQHGHAPLCCPLLETAAGSELPRLPEL---LPQADIVIAVS 57
Query: 61 KSAVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNA 120
AV F L TG W + YF VGQ +A F A + P SEGLL L A
Sbjct: 58 VHAVHFTHHFLLQTGQTWP-SIDYFAVGQASADAF-ADVGIEASCPD-DPRSEGLLALPA 114
Query: 121 MQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRAGIQ 180
+Q +S K VLILRGNGGR+L A RGA V Y R + T + AG+
Sbjct: 115 LQQVSGKRVLILRGNGGRDLIARTLASRGALVHYCAAYERHYPELDGDTLTRHWQAAGLD 174
Query: 181 TIVVTSAEILTQLVDFVPQNEHNWLKSCQLITVSERIAHLAEALGWQNVVISPRADNQTL 240
++++TS E+L +L++ VP + WL L+ S R+A +A+ G+ ++ I+ A NQ L
Sbjct: 175 SLLITSGELLQRLLELVPGQQQPWLYDRLLVVPSPRVADMAKMAGFTHITIAQGASNQAL 234
Query: 241 LQTL 244
L
Sbjct: 235 TAAL 238
>gi|120600513|ref|YP_965087.1| Uroporphyrinogen III synthase HEM4 [Shewanella sp. W3-18-1]
gi|120560606|gb|ABM26533.1| Uroporphyrinogen III synthase HEM4 [Shewanella sp. W3-18-1]
Length = 246
Score = 129 bits (325), Expect = 1e-28, Method: Composition-based stats.
Identities = 87/247 (35%), Positives = 121/247 (48%), Gaps = 6/247 (2%)
Query: 1 MAVLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVS 60
M VL+TRP+ R Q +VD L G+ PL +E ++ + L D + +S
Sbjct: 1 MKVLLTRPEGRNQSMVDALNARGIAHYVTPLLGVEPTNDITT--DASHPLAGTDIIICIS 58
Query: 61 KSAVDFAFKTLT---ATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQ 117
+AV FA K L A W + YF VG T + V P + +EGLL
Sbjct: 59 ANAVIFANKALNKINAQIATWPK-VQYFAVGHATWEALDQLGICAVEAPDDCQQTEGLLT 117
Query: 118 LNAMQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRA 177
L ++Q + K V I+RG GGRE AEQ RGANV E Y+R + T +
Sbjct: 118 LTSLQHIPAKKVTIIRGVGGREALAEQLTSRGANVRYWEVYQRVCPPLDGYAITQQWQHF 177
Query: 178 GIQTIVVTSAEILTQLVDFVPQNEHNWLKSCQLITVSERIAHLAEALGWQNVVISPRADN 237
GI TIVVTS E+L L+ VP+ WL+SC +I S R+ A A G +V + A++
Sbjct: 178 GIDTIVVTSGEVLNNLIKLVPKELFAWLRSCHIIVPSNRVEAQAHAFGINHVTNACAANS 237
Query: 238 QTLLQTL 244
+ +L L
Sbjct: 238 KAVLNAL 244
>gi|146294671|ref|YP_001185095.1| Uroporphyrinogen III synthase HEM4 [Shewanella putrefaciens CN-32]
gi|145566361|gb|ABP77296.1| Uroporphyrinogen III synthase HEM4 [Shewanella putrefaciens CN-32]
Length = 246
Score = 129 bits (325), Expect = 1e-28, Method: Composition-based stats.
Identities = 87/247 (35%), Positives = 122/247 (49%), Gaps = 6/247 (2%)
Query: 1 MAVLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVS 60
M VL+TRP+ R Q +VD L G+ PL +E ++ + L D + +S
Sbjct: 1 MKVLLTRPEGRNQSMVDALNARGITHYVTPLLGVEPTNDITT--DASHPLAGTDIIICIS 58
Query: 61 KSAVDFAFKTLT---ATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQ 117
+AV FA K L A W + YF VG T + V P + +EGLL
Sbjct: 59 ANAVIFANKALNKINAQIATWPK-VQYFAVGHATWEALDQLGICAVEAPDDCQQTEGLLT 117
Query: 118 LNAMQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRA 177
L ++Q + K V I+RG GGRE AEQ +RGANV E Y+R + T +
Sbjct: 118 LASLQHIPAKKVTIIRGVGGREALAEQLTRRGANVRYWEVYQRVCPPLDGYAITQQWQHF 177
Query: 178 GIQTIVVTSAEILTQLVDFVPQNEHNWLKSCQLITVSERIAHLAEALGWQNVVISPRADN 237
GI TIVVTS E+L L+ VP+ WL+SC +I S R+ A A G +V + A++
Sbjct: 178 GIDTIVVTSGEVLNNLIKLVPKELFAWLRSCHIIVPSNRVEAQAHAFGINHVTNACAANS 237
Query: 238 QTLLQTL 244
+ +L L
Sbjct: 238 KAVLNAL 244
>gi|124546386|ref|ZP_01705482.1| Uroporphyrinogen III synthase HEM4 [Shewanella putrefaciens 200]
gi|124510113|gb|EAY54185.1| Uroporphyrinogen III synthase HEM4 [Shewanella putrefaciens 200]
Length = 246
Score = 129 bits (324), Expect = 2e-28, Method: Composition-based stats.
Identities = 87/247 (35%), Positives = 121/247 (48%), Gaps = 6/247 (2%)
Query: 1 MAVLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVS 60
M VL+TRP+ R Q +VD L G+ PL +E ++ + L D + +S
Sbjct: 1 MKVLLTRPEGRNQSMVDALNARGIAHYVTPLLGVEPTNDITT--DASHPLAGTDIIICIS 58
Query: 61 KSAVDFAFKTLT---ATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQ 117
+AV FA K L A W + YF VG T + V P + +EGLL
Sbjct: 59 ANAVIFANKALNKINAQIATWPK-VQYFAVGHATWEALDQLGICAVEAPDDCQQTEGLLT 117
Query: 118 LNAMQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRA 177
L ++Q + K V I+RG GGRE AEQ RGANV E Y+R + T +
Sbjct: 118 LASLQHIPAKKVTIIRGVGGREALAEQLTSRGANVRYWEVYQRVCPPLDGYAITQQWQHF 177
Query: 178 GIQTIVVTSAEILTQLVDFVPQNEHNWLKSCQLITVSERIAHLAEALGWQNVVISPRADN 237
GI TIVVTS E+L L+ VP+ WL+SC +I S R+ A A G +V + A++
Sbjct: 178 GIDTIVVTSGEVLNNLIKLVPKELFAWLRSCHIIVPSNRVEAQAHAFGINHVTNACAANS 237
Query: 238 QTLLQTL 244
+ +L L
Sbjct: 238 KAVLNAL 244
>gi|24375796|ref|NP_719839.1| uroporphyrinogen-III synthase [Shewanella oneidensis MR-1]
gi|24350744|gb|AAN57283.1|AE015863_12 uroporphyrinogen-III synthase [Shewanella oneidensis MR-1]
Length = 246
Score = 126 bits (317), Expect = 1e-27, Method: Composition-based stats.
Identities = 87/247 (35%), Positives = 120/247 (48%), Gaps = 6/247 (2%)
Query: 1 MAVLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVS 60
M VL+TRP+ R Q +VD L + G+ PL +E+ L P L N D V +S
Sbjct: 1 MKVLLTRPEGRNQSMVDALNERGIEHCVTPLLCVEATPALP--PETSHPLANVDMVVCIS 58
Query: 61 KSAVDFA---FKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQ 117
+AV FA FK A W + YF VG T + + P + +EGLL
Sbjct: 59 ANAVSFADDTFKANDANVKGWPK-VPYFAVGHATWEALQQIDIDALEAPDDCQQTEGLLT 117
Query: 118 LNAMQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRA 177
L +Q + K + I+RG GGRE AEQ RGA V E Y+R + T
Sbjct: 118 LPTLQHIQGKKITIIRGVGGREALAEQLTSRGAQVRYWEVYQRACPPLDGTIITQQWIDL 177
Query: 178 GIQTIVVTSAEILTQLVDFVPQNEHNWLKSCQLITVSERIAHLAEALGWQNVVISPRADN 237
GI T+VVTS E+L L++ VP+ WL+SC +I S R+ A A G V + A++
Sbjct: 178 GIDTVVVTSGEVLDNLINLVPKELFAWLRSCHIIVPSNRVEAQAHAFGITQVTNANAANS 237
Query: 238 QTLLQTL 244
+ +L L
Sbjct: 238 KAVLNAL 244
>gi|117619183|ref|YP_855001.1| uroporphyrinogen-III synthase [Aeromonas hydrophila subsp.
hydrophila ATCC 7966]
gi|117560590|gb|ABK37538.1| uroporphyrinogen-III synthase [Aeromonas hydrophila subsp.
hydrophila ATCC 7966]
Length = 244
Score = 126 bits (317), Expect = 1e-27, Method: Composition-based stats.
Identities = 88/245 (35%), Positives = 128/245 (52%), Gaps = 8/245 (3%)
Query: 1 MAVLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVS 60
M LV RP + +L +L + G + PL +G+EL+ LP L D V AVS
Sbjct: 1 MIPLVVRPAAQAAELAALLRQHGHAPLCCPLLETVAGSELHRLPEL---LPQADIVIAVS 57
Query: 61 KSAVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQE-NSEGLLQLN 119
AV+F L TG W ++ YF VGQ +A F+ E+ + + + SEGLL L
Sbjct: 58 VHAVNFTHHFLLQTGQTWP-NIDYFAVGQASADAFS---EVGIQALSPDDPRSEGLLALP 113
Query: 120 AMQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRAGI 179
++Q ++ K VLILRGNGGR+L A RGA V Y R + T + AG+
Sbjct: 114 SLQQVNGKQVLILRGNGGRDLIARTLASRGALVHYCAAYERHYPALDGDALTCHWQAAGL 173
Query: 180 QTIVVTSAEILTQLVDFVPQNEHNWLKSCQLITVSERIAHLAEALGWQNVVISPRADNQT 239
+++VTS E+L +L++ VP + WL L+ S R+A +A A G+ ++ I+ A NQ
Sbjct: 174 DSLLVTSGELLQRLLELVPDQQLPWLHDRLLVVPSPRVAEMAAAAGFTHITIAQGASNQA 233
Query: 240 LLQTL 244
L L
Sbjct: 234 LTAAL 238
>gi|153002482|ref|YP_001368163.1| Uroporphyrinogen III synthase HEM4 [Shewanella baltica OS185]
gi|151367100|gb|ABS10100.1| Uroporphyrinogen III synthase HEM4 [Shewanella baltica OS185]
Length = 246
Score = 124 bits (312), Expect = 4e-27, Method: Composition-based stats.
Identities = 83/247 (33%), Positives = 121/247 (48%), Gaps = 6/247 (2%)
Query: 1 MAVLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVS 60
M VL+TRP+ R Q +VD L + G+ PL +E+ + N L + D + +S
Sbjct: 1 MKVLLTRPEGRNQSMVDALNERGIAHWVTPLLCVEATPAIAT--NTPHPLAHADMIICIS 58
Query: 61 KSAVDFAFKTLTATG---FVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQ 117
+AV FA LT T W YF VG T + P + +EGLL
Sbjct: 59 ANAVTFADNALTTTNPPHKAWP-PAQYFAVGHATWDALDQLGISALEAPDDCQQTEGLLT 117
Query: 118 LNAMQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRA 177
L +Q++ K + I+RG GGRE AEQ RGA++ E Y+R + + +
Sbjct: 118 LAPLQEIKGKQITIIRGVGGREALAEQLAARGAHLRYWEVYQRACPPLDGQQLALQWQAF 177
Query: 178 GIQTIVVTSAEILTQLVDFVPQNEHNWLKSCQLITVSERIAHLAEALGWQNVVISPRADN 237
GI TIVVTS E+L L++ VP+ WL+SC +I S R+ A A G V + A++
Sbjct: 178 GIDTIVVTSGEVLDNLINLVPKELFAWLRSCHIIVPSNRVEAQAHAFGMTQVTNANAANS 237
Query: 238 QTLLQTL 244
+ +L L
Sbjct: 238 KAVLNAL 244
>gi|119947243|ref|YP_944923.1| Uroporphyrinogen III synthase HEM4 [Psychromonas ingrahamii 37]
gi|119865847|gb|ABM05324.1| Uroporphyrinogen III synthase HEM4 [Psychromonas ingrahamii 37]
Length = 244
Score = 120 bits (301), Expect = 7e-26, Method: Composition-based stats.
Identities = 86/239 (35%), Positives = 118/239 (49%), Gaps = 5/239 (2%)
Query: 3 VLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVSKS 62
+LVTR Q+LV++L G VA PL ++ E N AK N DY+ AVS +
Sbjct: 6 LLVTRFAPHAQRLVNLLNAQGTVAFAQPLLALQKTTEFNHASKVLAK--NYDYIIAVSPN 63
Query: 63 AVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNAMQ 122
AVD+ K L G W Y VG T A T V P +SEGLL L +
Sbjct: 64 AVDYTQKALA--GINWPQT-EYLAVGLATQAKLKAATTQNVVVPEKCFDSEGLLDLPLLL 120
Query: 123 DLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRAGIQTI 182
+L K +LILRG GGREL + +QRGA V+ + Y+R IV ++ I
Sbjct: 121 NLQGKHILILRGVGGRELLCDTLRQRGAIVDYYQPYQRVAIVLCGKALIKEWQQQNINGA 180
Query: 183 VVTSAEILTQLVDFVPQNEHNWLKSCQLITVSERIAHLAEALGWQNVVISPRADNQTLL 241
+++S E+L +L+ VP H WLK + SERI A+ GW N + P +Q ++
Sbjct: 181 IISSIELLERLMSVVPLAAHEWLKELTIYAPSERILDQAKRWGWSNTKVLPGMSDQQVI 239
>gi|91791754|ref|YP_561405.1| Uroporphyrinogen III synthase HEM4 [Shewanella denitrificans OS217]
gi|91713756|gb|ABE53682.1| Uroporphyrinogen III synthase HEM4 [Shewanella denitrificans OS217]
Length = 238
Score = 120 bits (301), Expect = 8e-26, Method: Composition-based stats.
Identities = 83/248 (33%), Positives = 129/248 (52%), Gaps = 16/248 (6%)
Query: 1 MAVLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVS 60
M VL+TRP+ R QQ+ D L + G+ PL I + P K A + D + +S
Sbjct: 1 MKVLLTRPEGRNQQMADALTQLGIGYHLCPLLEITP----SNTPPK-ASFFSADKLVFIS 55
Query: 61 KSAVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNA 120
+AV FA L + YF VG+ T + P++Q++SEGLL L+
Sbjct: 56 ANAVYFAANNLNNH---FPMHCEYFAVGEATQMALAEYQVVSQSAPSSQQDSEGLLSLSQ 112
Query: 121 MQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRR-EPIVYNNAEQTSICKR--- 176
+QD+ + + I+RG GGRE A+ +RGANV+ + Y+R +P + + S+C++
Sbjct: 113 LQDVELQKITIVRGEGGRETLAQTLSERGANVDYWQVYQRSKPAL----DPKSVCQQWQD 168
Query: 177 AGIQTIVVTSAEILTQLVDFVPQNEHNWLKSCQLITVSERIAHLAEALGWQNVVISPRAD 236
GI T+V+TS E L L++ VP+ WL+SC +I S R+ A + G+ V + A
Sbjct: 169 LGIDTLVLTSGEALANLMELVPKELFAWLRSCHMIVPSHRVQVQAISQGFHRVSNANGAS 228
Query: 237 NQTLLQTL 244
Q +L L
Sbjct: 229 TQAILTAL 236
>gi|118071325|ref|ZP_01539521.1| Uroporphyrinogen III synthase HEM4 [Shewanella woodyi ATCC 51908]
gi|118024387|gb|EAV38195.1| Uroporphyrinogen III synthase HEM4 [Shewanella woodyi ATCC 51908]
Length = 243
Score = 118 bits (295), Expect = 4e-25, Method: Composition-based stats.
Identities = 75/246 (30%), Positives = 128/246 (52%), Gaps = 9/246 (3%)
Query: 1 MAVLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVS 60
M +L+TRP R Q + + L + GV I PL +++ ++ ++ + A D + +S
Sbjct: 1 MKLLLTRPKGRNQSMSEALTQLGVPYIITPLLEVQA-SKTHQDQDAIAHFNAADIIIFIS 59
Query: 61 KSAVDFAFKTLTATGFVWRHDL-HYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLN 119
+AV+F+ + + +H ++ VG T Q A P+ + +EGLL L
Sbjct: 60 TNAVEFSSQVIELK----KHKTAQFYAVGDATFQALKALGIDAFAAPSDCQQTEGLLTLA 115
Query: 120 AMQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRRE-PIVYNNAEQTSICKRAG 178
+Q+L+ + ++I+RG GGRE AE+ QRGA V E Y+R P + N +
Sbjct: 116 DLQELTGQNIMIVRGVGGRETLAEKLTQRGAKVNYWETYQRACPAI--NERTPYLWHDEK 173
Query: 179 IQTIVVTSAEILTQLVDFVPQNEHNWLKSCQLITVSERIAHLAEALGWQNVVISPRADNQ 238
+ TI++TS EIL L+ VP+ WL++C +I S R+ A A G ++V + A+++
Sbjct: 174 VDTIIITSGEILHSLIKLVPKELFAWLRACHIIVPSSRVKEQALAYGLEHVTNAKAANSK 233
Query: 239 TLLQTL 244
+L L
Sbjct: 234 AMLSAL 239
>gi|113968731|ref|YP_732524.1| Uroporphyrinogen III synthase HEM4 [Shewanella sp. MR-4]
gi|113883415|gb|ABI37467.1| Uroporphyrinogen III synthase HEM4 [Shewanella sp. MR-4]
Length = 232
Score = 117 bits (294), Expect = 5e-25, Method: Composition-based stats.
Identities = 80/233 (34%), Positives = 115/233 (49%), Gaps = 6/233 (2%)
Query: 15 LVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVSKSAVDFA---FKTL 71
+VD L + G+ PL +E+ L P+ L + D V +S +AV FA FK
Sbjct: 1 MVDALTEKGIDHCVTPLLCVEATPPLP--PDTSHPLADVDMVICISANAVSFADAAFKVD 58
Query: 72 TATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNAMQDLSDKTVLI 131
TA W + YF VG T + + P + +EGLL L A+Q + K + I
Sbjct: 59 TAQVKDWP-SVPYFAVGHATWEALQEKGIEALEAPDDCQQTEGLLTLPALQHIQGKHITI 117
Query: 132 LRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRAGIQTIVVTSAEILT 191
+RG GGRE AEQ RGA V E Y+R + A + + GI TIV+TS E+L
Sbjct: 118 IRGVGGREALAEQLNARGAKVRYWEVYQRACPPLDGAAVSQQWRDFGIDTIVITSGEVLD 177
Query: 192 QLVDFVPQNEHNWLKSCQLITVSERIAHLAEALGWQNVVISPRADNQTLLQTL 244
L++ VP+ WL+SC +I S R+ A A G V + A+++ +L L
Sbjct: 178 NLINLVPKELFAWLRSCHIIVPSNRVEAQAHAFGITQVTNANAANSKAVLNAL 230
>gi|114049126|ref|YP_739676.1| Uroporphyrinogen III synthase HEM4 [Shewanella sp. MR-7]
gi|113890568|gb|ABI44619.1| Uroporphyrinogen III synthase HEM4 [Shewanella sp. MR-7]
Length = 232
Score = 117 bits (292), Expect = 8e-25, Method: Composition-based stats.
Identities = 80/233 (34%), Positives = 114/233 (48%), Gaps = 6/233 (2%)
Query: 15 LVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVSKSAVDFA---FKTL 71
+VD L G+ PL +E+ L P+ L + D V +S +AV FA FK
Sbjct: 1 MVDALTAKGIDHCVTPLLCVEATPPLP--PDTSHPLADVDMVICISANAVSFADAAFKVD 58
Query: 72 TATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNAMQDLSDKTVLI 131
TA W + YF VG T + + P + +EGLL L A+Q + K + I
Sbjct: 59 TAQVKDWP-SVPYFAVGHATWEALQEKGIEALEAPDDCQQTEGLLTLPALQHIQGKHITI 117
Query: 132 LRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRAGIQTIVVTSAEILT 191
+RG GGRE AEQ RGA V E Y+R + A + + GI TIV+TS E+L
Sbjct: 118 IRGVGGREALAEQLSARGAKVRYWEVYQRACPPLDGAAVSQQWRDFGIDTIVITSGEVLD 177
Query: 192 QLVDFVPQNEHNWLKSCQLITVSERIAHLAEALGWQNVVISPRADNQTLLQTL 244
L++ VP+ WL+SC +I S R+ A A G V + A+++ +L L
Sbjct: 178 NLINLVPKELFAWLRSCHIIVPSNRVEAQAHAFGITQVTNANAANSKAVLNAL 230
>gi|117918842|ref|YP_868034.1| Uroporphyrinogen III synthase HEM4 [Shewanella sp. ANA-3]
gi|117611174|gb|ABK46628.1| Uroporphyrinogen III synthase HEM4 [Shewanella sp. ANA-3]
Length = 232
Score = 116 bits (291), Expect = 1e-24, Method: Composition-based stats.
Identities = 79/233 (33%), Positives = 114/233 (48%), Gaps = 6/233 (2%)
Query: 15 LVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVSKSAVDFA---FKTL 71
+VD L + G+ PL +E+ L P+ L + D V +S +AV FA F
Sbjct: 1 MVDALTEKGIDHCVTPLLCVEATPPLP--PDTSHPLADVDMVICISANAVSFADAAFNVD 58
Query: 72 TATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNAMQDLSDKTVLI 131
TA W + YF VG T + + P + +EGLL L A+Q + K + I
Sbjct: 59 TAQVKDWP-SVPYFAVGHATCEALQEKGIEALEAPDDCQQTEGLLTLPALQHIQGKHITI 117
Query: 132 LRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRAGIQTIVVTSAEILT 191
+RG GGRE AEQ RGA V E Y+R + A + + GI TIV+TS E+L
Sbjct: 118 IRGVGGREALAEQLNARGAKVRYWEVYQRACPPLDGAAVSQQWRDFGIDTIVITSGEVLD 177
Query: 192 QLVDFVPQNEHNWLKSCQLITVSERIAHLAEALGWQNVVISPRADNQTLLQTL 244
L++ VP+ WL+SC +I S R+ A A G V + A+++ +L L
Sbjct: 178 NLINLVPKELFAWLRSCHIIVPSNRVEAQAHAFGITQVTNANAANSKAVLNAL 230
>gi|119776387|ref|YP_929127.1| uroporphyrinogen-III synthase [Shewanella amazonensis SB2B]
gi|119768887|gb|ABM01458.1| uroporphyrinogen-III synthase [Shewanella amazonensis SB2B]
Length = 239
Score = 112 bits (281), Expect = 2e-23, Method: Composition-based stats.
Identities = 75/244 (30%), Positives = 116/244 (47%), Gaps = 7/244 (2%)
Query: 1 MAVLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVS 60
M +L+TRP+ + + L + + PL +E+ A + +L D + +S
Sbjct: 1 MKLLLTRPEGKNAAMASALDALAIPYLVEPLLSVEAAAVTQA---QLDELSRADILIFIS 57
Query: 61 KSAVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNA 120
SAV FA L W Y+ VG TA P + +EGLL L +
Sbjct: 58 TSAVSFATPWLKDQ---WPKAT-YYAVGDATADALALQGITAERSPADSQATEGLLTLPS 113
Query: 121 MQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRAGIQ 180
++ +S K ++I+RG GGRE A+ + RGANV +E Y+R + S + GI
Sbjct: 114 LEQVSGKQIVIVRGKGGREAMADGLRLRGANVSYLEVYQRACPPLDAPASVSRWQSFGID 173
Query: 181 TIVVTSAEILTQLVDFVPQNEHNWLKSCQLITVSERIAHLAEALGWQNVVISPRADNQTL 240
TIVVTS E+L L++ VP++ WL+ C +I S R+ A G + V + A+ +
Sbjct: 174 TIVVTSGEVLENLINLVPKDSFAWLRDCHIIVPSARVETQARKKGLRRVTNAGAANQAAV 233
Query: 241 LQTL 244
L L
Sbjct: 234 LDAL 237
>gi|127511251|ref|YP_001092448.1| Uroporphyrinogen III synthase HEM4 [Shewanella loihica PV-4]
gi|126636546|gb|ABO22189.1| Uroporphyrinogen III synthase HEM4 [Shewanella loihica PV-4]
Length = 243
Score = 111 bits (277), Expect = 5e-23, Method: Composition-based stats.
Identities = 79/250 (31%), Positives = 120/250 (48%), Gaps = 17/250 (6%)
Query: 1 MAVLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVS 60
M +L+TRP+ R Q + + L++ V PL + + E + +K D + +S
Sbjct: 1 MKLLLTRPEGRNQSMAEALSQRDVPFTIAPLLAVVANNEADH-EHKKKLFYQSDIIIFIS 59
Query: 61 KSAVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNA 120
+AV++A L++ W D YF VGQ T + P + + +EGLL L
Sbjct: 60 TNAVEYADIALSSA---WPKDKQYFAVGQATYCALKDKGIVAFEAPESCQQTEGLLTLAQ 116
Query: 121 MQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRR-----EP-IVYNNAEQTSIC 174
+Q ++ + + I+RG GGRE A + RGA V+ E YRR +P Y EQ
Sbjct: 117 LQAITGQQITIVRGVGGRETLASELADRGAKVDYWEVYRRACPQLDPHTPYEWREQ---- 172
Query: 175 KRAGIQTIVVTSAEILTQLVDFVPQNEHNWLKSCQLITVSERIAHLAEALGWQNVVISPR 234
I TIV+TS EIL L+ VP+ WL +C +I S R+ A A G+ V +
Sbjct: 173 ---AIDTIVITSGEILANLITLVPKELFAWLHACHIIVPSARVYDQAIAAGFTRVTNAKA 229
Query: 235 ADNQTLLQTL 244
A+ +L L
Sbjct: 230 ANRDAVLTAL 239
>gi|118754283|ref|ZP_01602081.1| Uroporphyrinogen III synthase HEM4 [Shewanella pealeana ATCC
700345]
gi|118694299|gb|EAW00518.1| Uroporphyrinogen III synthase HEM4 [Shewanella pealeana ATCC
700345]
Length = 243
Score = 110 bits (275), Expect = 7e-23, Method: Composition-based stats.
Identities = 74/245 (30%), Positives = 119/245 (48%), Gaps = 6/245 (2%)
Query: 1 MAVLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAK-LKNGDYVFAV 59
M +L+TRP+ R Q + + L + V PL ++ + L+ N+ K LK D + +
Sbjct: 1 MKILLTRPEGRNQLMKEALTQRNVSYFITPLLNVQPTSNLD--ANQIDKQLKLADIIIFI 58
Query: 60 SKSAVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLN 119
S +AV FA + + W YF VG T P + +EGLL L
Sbjct: 59 STNAVAFASQAIDNQ---WPSSAQYFAVGDATHAALKQLGIDAQRAPEDCQQTEGLLTLT 115
Query: 120 AMQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRAGI 179
++ D++ K ++I+RG GGRE A + +R A + E Y+R ++A + GI
Sbjct: 116 SLADVTGKQIIIVRGQGGREDLATELIKRNAQLSYWEVYKRGCPALDSANLCQQWRSFGI 175
Query: 180 QTIVVTSAEILTQLVDFVPQNEHNWLKSCQLITVSERIAHLAEALGWQNVVISPRADNQT 239
TI++TS EIL L+ VP+ WL++C +I S R+ A+A +V + A+
Sbjct: 176 DTIIITSGEILDNLIKTVPKELFAWLQTCHIIVPSPRVYEKAKAYNLLHVSNATAANTNA 235
Query: 240 LLQTL 244
+L L
Sbjct: 236 MLAAL 240
>gi|90416176|ref|ZP_01224108.1| uroporphyrinogen-III synthetase [marine gamma proteobacterium
HTCC2207]
gi|90331901|gb|EAS47115.1| uroporphyrinogen-III synthetase [marine gamma proteobacterium
HTCC2207]
Length = 243
Score = 109 bits (272), Expect = 2e-22, Method: Composition-based stats.
Identities = 73/241 (30%), Positives = 128/241 (53%), Gaps = 11/241 (4%)
Query: 3 VLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVSKS 62
+LV RP + Q +++L +AG H+P+ IE + + N ++ N D VS +
Sbjct: 5 ILVIRPLRQADQFIELLERAGNQVCHIPVMAIEPVVDGQSIKNLILEVDNFDKAICVSGN 64
Query: 63 AVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNAMQ 122
A + A + L + + YF +GQ TA A ++ P+ ++NSE LL L +Q
Sbjct: 65 AAELAIEWLDRYWPMQPVGIEYFAIGQQTAHILGAA-DIVALSPSGRQNSEALLALPELQ 123
Query: 123 DLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRAGIQT- 181
DLSD+ V++ RG GGRE+ + +RGA V+ E Y R N ++ + ++ +++
Sbjct: 124 DLSDQRVIVFRGRGGREILGDTLIERGARVDYCELYER----VINPQKALLARKQMLESD 179
Query: 182 -IVVTSAEILTQLVDFVPQNEHNWLKSCQLITVSERIAHLAEALGWQNVVISPRADNQTL 240
+V S E+LT L D Q+ + ++ ++ SER+A +A LG++N+V + A + +
Sbjct: 180 CLVAHSGELLTALGD---QSGESGAETA-VVVPSERVAEIAWKLGYRNIVSAENALPEAM 235
Query: 241 L 241
L
Sbjct: 236 L 236
>gi|53802805|ref|YP_115448.1| uroporphyrinogen-III synthase/uroporphyrin-III C-methyltransferase
[Methylococcus capsulatus str. Bath]
gi|53756566|gb|AAU90857.1| uroporphyrinogen-III synthase/uroporphyrin-III C-methyltransferase
[Methylococcus capsulatus str. Bath]
Length = 672
Score = 109 bits (272), Expect = 2e-22, Method: Composition-based stats.
Identities = 79/246 (32%), Positives = 121/246 (49%), Gaps = 6/246 (2%)
Query: 1 MAVLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVS 60
M VLVTRP E+ + L ++ AG A+ PL IE A+ E + + D+ VS
Sbjct: 1 MRVLVTRPKEQAEPLCRLIETAGGKAVRFPLLDIEPSAQAEEGAALLRQASDWDWWIFVS 60
Query: 61 KSAVDFA--FKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQL 118
+AV+ A L G R +G+ TA P +Q NSEGLL+
Sbjct: 61 VNAVNRARALDVLRPDGAGPR----IAAIGKATADALVDGGIAVDLVPESQANSEGLLET 116
Query: 119 NAMQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRAG 178
M+D++ + +LI+RG GGRE E+ +RGA V+ E YRR P+ + AG
Sbjct: 117 PPMRDVAGRRILIVRGEGGRETLKERLVERGALVQYAELYRRVPVHTGAEALIEGLRTAG 176
Query: 179 IQTIVVTSAEILTQLVDFVPQNEHNWLKSCQLITVSERIAHLAEALGWQNVVISPRADNQ 238
+ + TS E + L VP + L L+ +SER+ + A +LG+++V ++ A +
Sbjct: 177 LDMLTATSGEAIEHLYRLVPPEDRPRLVETPLVVISERLKNQAGSLGFRHVKVADAASDA 236
Query: 239 TLLQTL 244
+LQ L
Sbjct: 237 AVLQAL 242
>gi|149114245|ref|ZP_01840999.1| Uroporphyrinogen III synthase HEM4 [Shewanella baltica OS223]
gi|146865942|gb|EDK51210.1| Uroporphyrinogen III synthase HEM4 [Shewanella baltica OS223]
Length = 232
Score = 109 bits (272), Expect = 2e-22, Method: Composition-based stats.
Identities = 76/233 (32%), Positives = 112/233 (48%), Gaps = 6/233 (2%)
Query: 15 LVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVSKSAVDFAFKTLTAT 74
+VD L + G+ PL +E+ + N L + D V +S +AV FA LT T
Sbjct: 1 MVDALNERGIAHWVTPLLCVEATPAIAT--NTPHPLAHADMVICISANAVTFADNALTTT 58
Query: 75 G---FVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNAMQDLSDKTVLI 131
W YF VG T + + P + +EGLL L +Q++ K + I
Sbjct: 59 NPPHKAWP-PAQYFAVGHATWKALDQLGISALEAPDDCQQTEGLLTLAPLQEIKGKQITI 117
Query: 132 LRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRAGIQTIVVTSAEILT 191
+RG GGRE AEQ RGA++ E Y+R + + + GI TIVVTS E+L
Sbjct: 118 IRGVGGREALAEQLAARGAHLRYWEVYQRACPPLDGQQLALQWQAFGIDTIVVTSGEVLD 177
Query: 192 QLVDFVPQNEHNWLKSCQLITVSERIAHLAEALGWQNVVISPRADNQTLLQTL 244
L++ VP+ WL+SC +I S R+ A A G V + A+++ +L L
Sbjct: 178 NLINLVPKELFAWLRSCHIIVPSNRVEAQAHAFGITQVTNANAANSKAVLNAL 230
>gi|126176188|ref|YP_001052337.1| Uroporphyrinogen III synthase HEM4 [Shewanella baltica OS155]
gi|125999393|gb|ABN63468.1| Uroporphyrinogen III synthase HEM4 [Shewanella baltica OS155]
Length = 232
Score = 108 bits (270), Expect = 3e-22, Method: Composition-based stats.
Identities = 75/233 (32%), Positives = 112/233 (48%), Gaps = 6/233 (2%)
Query: 15 LVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVSKSAVDFAFKTLTAT 74
+VD L + G+ PL +E+ + N L + D + +S +AV FA TLT T
Sbjct: 1 MVDALNERGIAHWVTPLLCVEATPAIAT--NTPHPLAHADMIICISANAVTFADNTLTTT 58
Query: 75 G---FVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNAMQDLSDKTVLI 131
W YF VG T + P + +EGLL L +Q++ + + I
Sbjct: 59 NPPHKAWP-PAQYFAVGHATWDALNQLGISALEAPDDCQQTEGLLTLVPLQEIKGQQITI 117
Query: 132 LRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRAGIQTIVVTSAEILT 191
+RG GGRE AEQ RGA++ E Y+R + + + GI TIVVTS E+L
Sbjct: 118 IRGVGGREALAEQLAARGAHLRYWEVYQRACPPLDGQQLALQWQAFGIDTIVVTSGEVLD 177
Query: 192 QLVDFVPQNEHNWLKSCQLITVSERIAHLAEALGWQNVVISPRADNQTLLQTL 244
L++ VP+ WL+SC +I S R+ A A G V + A+++ +L L
Sbjct: 178 NLINLVPKELFAWLRSCHIIVPSNRVEAQAHAFGITQVTNANAANSKAVLNAL 230
>gi|94501431|ref|ZP_01307950.1| uroporphyrinogen-III synthetase [Oceanobacter sp. RED65]
gi|94426396|gb|EAT11385.1| uroporphyrinogen-III synthetase [Oceanobacter sp. RED65]
Length = 255
Score = 108 bits (270), Expect = 3e-22, Method: Composition-based stats.
Identities = 80/255 (31%), Positives = 125/255 (49%), Gaps = 13/255 (5%)
Query: 2 AVLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIE-----SGAELNELPNKFAKLKNGDYV 56
++LVTRP +GQ ++ L +AG+ +H PL +IE GA+ ++L + L D V
Sbjct: 3 SLLVTRPQGQGQGMMIELEQAGIQVVHQPLLKIEPLKMEDGADYHQLKQRIVDLDLYDTV 62
Query: 57 FAVSKSAVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTA---TTEMPVHYPTAQENSE 113
VS +A A + +F VG +A+ + M + P +SE
Sbjct: 63 ICVSSNAAQLASDWIDQYWPQLPVKQQWFAVGPSSAEPLLPLLDSAAMDIQVPEGN-HSE 121
Query: 114 GLLQLNAMQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSI 173
GLL L ++D+++K VLILRG GGREL ++RGA+V E YRR P+ + ++
Sbjct: 122 GLLALPQLRDMTEKKVLILRGVGGRELIKSTLEERGASVHYAEFYRRTPVDLTQQQLQTL 181
Query: 174 CKRAGIQTIVVTSAEILTQLVDFVPQNEHNWLKSCQLITVSERIAHLAEALGWQNVVISP 233
I ++TS E++ Q +P N K L+ SERI +A LG+Q I
Sbjct: 182 LTEHQIHYALLTSGEMVQQFHQALP----NTPKDLHLLVPSERIQKMAIDLGFQQTHICQ 237
Query: 234 RADNQTLLQTLLQCR 248
Q +L+++ R
Sbjct: 238 PITAQAVLKSINDIR 252
>gi|24209804|gb|AAN39862.1| HemD protein [Salmonella enterica subsp. enterica serovar Agona]
Length = 144
Score = 108 bits (269), Expect = 3e-22, Method: Composition-based stats.
Identities = 61/143 (42%), Positives = 78/143 (54%)
Query: 48 AKLKNGDYVFAVSKSAVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPT 107
A L D VFA+S+ AV FA L G W YF +G+ TA + + YP
Sbjct: 1 ATLTENDLVFALSQHAVAFAHAQLQRDGRNWPASPRYFAIGRTTALALHTVSGFDIRYPL 60
Query: 108 AQENSEGLLQLNAMQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNN 167
+E SE LLQL +Q+++ K LILRGNGGREL E RGA V ECY+R Y+
Sbjct: 61 DREISEALLQLPELQNIAGKRALILRGNGGRELLGETLTARGAEVSFCECYQRCAKHYDG 120
Query: 168 AEQTSICKRAGIQTIVVTSAEIL 190
AE+ G+ T+VVTS E+L
Sbjct: 121 AEEAMRWHTRGVTTLVVTSGEML 143
>gi|24209828|gb|AAN39874.1| HemD protein [Salmonella enteritidis]
Length = 144
Score = 107 bits (268), Expect = 4e-22, Method: Composition-based stats.
Identities = 61/143 (42%), Positives = 78/143 (54%)
Query: 48 AKLKNGDYVFAVSKSAVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPT 107
A L D VFA+S+ AV FA L G W YF +G+ TA + + YP
Sbjct: 1 ATLTENDLVFALSQHAVAFAHAQLQRDGRNWPAPPRYFAIGRTTALALHTVSGFDIRYPL 60
Query: 108 AQENSEGLLQLNAMQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNN 167
+E SE LLQL +Q+++ K LILRGNGGREL E RGA V ECY+R Y+
Sbjct: 61 DREISEALLQLPELQNIAGKRALILRGNGGRELLGETLTARGAEVSFCECYQRCAKHYDG 120
Query: 168 AEQTSICKRAGIQTIVVTSAEIL 190
AE+ G+ T+VVTS E+L
Sbjct: 121 AEEAMRWHTRGVTTLVVTSGEML 143
>gi|113947677|ref|ZP_01433342.1| Uroporphyrinogen III synthase HEM4 [Shewanella baltica OS195]
gi|113910111|gb|EAU28751.1| Uroporphyrinogen III synthase HEM4 [Shewanella baltica OS195]
Length = 232
Score = 107 bits (268), Expect = 5e-22, Method: Composition-based stats.
Identities = 75/233 (32%), Positives = 111/233 (47%), Gaps = 6/233 (2%)
Query: 15 LVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVSKSAVDFAFKTLTAT 74
+VD L + G+ PL +E+ + N L + D + +S +AV FA LTA
Sbjct: 1 MVDALNERGIAHWVTPLLCVEATPAIAT--NTPHPLAHADMIICISANAVTFADNALTAA 58
Query: 75 G---FVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNAMQDLSDKTVLI 131
W YF VG T + P + +EGLL L +Q++ K + I
Sbjct: 59 NPHTKAWP-PAQYFAVGHATWDALDQLGISALEAPDDCQQTEGLLTLAPLQEIKGKQITI 117
Query: 132 LRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRAGIQTIVVTSAEILT 191
+RG GGRE AEQ RGA++ E Y+R + + + GI TIVVTS E+L
Sbjct: 118 IRGVGGREALAEQLAARGAHLRYWEVYQRACPPLDGQQLALQWQAFGIDTIVVTSGEVLD 177
Query: 192 QLVDFVPQNEHNWLKSCQLITVSERIAHLAEALGWQNVVISPRADNQTLLQTL 244
L++ VP+ WL+SC +I S R+ A A G V + A+++ +L L
Sbjct: 178 NLINLVPKELFAWLRSCHIIVPSNRVEAQAHAFGITQVTNANAANSKAVLNAL 230
>gi|56461659|ref|YP_156940.1| Uroporphyrinogen-III synthase [Idiomarina loihiensis L2TR]
gi|56180669|gb|AAV83391.1| Uroporphyrinogen-III synthase [Idiomarina loihiensis L2TR]
Length = 251
Score = 107 bits (268), Expect = 5e-22, Method: Composition-based stats.
Identities = 85/251 (33%), Positives = 121/251 (48%), Gaps = 21/251 (8%)
Query: 2 AVLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELP-NKFA----KLKNGDYV 56
AVL+ RP + L K G + S E+ LP NK K K+ D +
Sbjct: 8 AVLLLRPGKSPDDFTQQLRKTGRECF------VHSFIEIEPLPVNKEQLTQIKQKHWDGI 61
Query: 57 FAVSKSAVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLL 116
VSK+A +A + GF Y+ VG GTA + V P SEGLL
Sbjct: 62 VIVSKNAAHYA----SRAGFSGVPS-KYYAVGPGTASFACKHLNTAVSCPAFIHQSEGLL 116
Query: 117 QLNAMQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAE--QTSIC 174
+L+ +Q L + LI+RG GGREL A+ + RGA+V+ E YRR+ + N+ E Q I
Sbjct: 117 ELSELQKLQQQNWLIIRGEGGRELLADAIRARGASVDYWEVYRRKQLTLNDPELIQQWI- 175
Query: 175 KRAGIQTIVVTSAEILTQLVDFVPQNEHNWLKSCQLITVSERIAHLAEALGWQNVVISPR 234
+ + TIVVTSAE L + +P + +WL SCQ I S R+ L N+ ++
Sbjct: 176 --SSVGTIVVTSAEQLGYFLSSMPNSAQSWLDSCQWIVPSHRLKGLIPFGQSDNIKVTGS 233
Query: 235 ADNQTLLQTLL 245
A + L+ L+
Sbjct: 234 AADAILMNALI 244
>gi|24209796|gb|AAN39858.1| HemD protein [Salmonella typhi]
gi|24209820|gb|AAN39870.1| HemD protein [Salmonella typhi]
Length = 144
Score = 107 bits (267), Expect = 6e-22, Method: Composition-based stats.
Identities = 60/143 (41%), Positives = 79/143 (55%)
Query: 48 AKLKNGDYVFAVSKSAVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPT 107
A L D VFA+S+ +V FA L G W YF++G+ TA + + YP
Sbjct: 1 ATLTENDLVFALSQHSVAFAHAQLQRDGRNWPASPRYFSIGRTTALALHTVSGFDIRYPL 60
Query: 108 AQENSEGLLQLNAMQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNN 167
+E SE LLQL +Q+++ K LILRGNGGREL E RGA V ECY+R Y+
Sbjct: 61 DREISEALLQLPELQNIAGKRALILRGNGGRELLGETLTVRGAEVSFCECYQRCAKHYDG 120
Query: 168 AEQTSICKRAGIQTIVVTSAEIL 190
AE+ G+ T+VVTS E+L
Sbjct: 121 AEEAMRWHTRGVTTLVVTSGEML 143
>gi|88861268|ref|ZP_01135900.1| uroporphyrinogen-III synthase HemD (N terminal)/Uroporphyrin-III
C-methyltransferase (C terminal) [Pseudoalteromonas
tunicata D2]
gi|88816749|gb|EAR26572.1| uroporphyrinogen-III synthase HemD (N terminal)/Uroporphyrin-III
C-methyltransferase (C terminal) [Pseudoalteromonas
tunicata D2]
Length = 614
Score = 105 bits (262), Expect = 2e-21, Method: Composition-based stats.
Identities = 79/246 (32%), Positives = 122/246 (49%), Gaps = 10/246 (4%)
Query: 3 VLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVSKS 62
+LVTRPD +G +LV L K G AI PL +E A + A L D + +S+
Sbjct: 4 ILVTRPDTKGAELVAQLKKLGHHAISFPLLALEPLAVSSA---ALAPLGEADKLIFISQD 60
Query: 63 AVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNAMQ 122
AV K L A +H +F VG+ TA + Q+ SEGLL L +Q
Sbjct: 61 AV----KALYALKPNLKHQPQFFAVGEKTAAVIAELFGVKARIAKPQD-SEGLLALKELQ 115
Query: 123 DLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRAGIQTI 182
+ + +++L+G GR L A++ +QRGA V V YRR+P+ + ++ I +I
Sbjct: 116 HIEQQNIVLLKGQDGRPLIAQKLKQRGAFVHAVVLYRRQPVKGVASGWIKQWQQQKIDSI 175
Query: 183 VVTSAEILTQLVDFVPQNEHNWLKSCQLITVSERIAHLAE--ALGWQNVVISPRADNQTL 240
V+TS + + + +NE WLK+C+ SERIA+ A+ N+ I A ++ +
Sbjct: 176 VLTSNAAVDAIFRELAENEVKWLKTCRFYVASERIANYLSQFAIAANNIQICAGASDEAI 235
Query: 241 LQTLLQ 246
L + Q
Sbjct: 236 LTAISQ 241
>gi|150378783|ref|ZP_01917980.1| Uroporphyrinogen III synthase HEM4 [Shewanella sediminis HAW-EB3]
gi|150255952|gb|EDM93645.1| Uroporphyrinogen III synthase HEM4 [Shewanella sediminis HAW-EB3]
Length = 230
Score = 103 bits (256), Expect = 1e-20, Method: Composition-based stats.
Identities = 71/230 (30%), Positives = 111/230 (48%), Gaps = 4/230 (1%)
Query: 15 LVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVSKSAVDFAFKTLTAT 74
+++ L + GV + PL +++ ++ + + D V +S +AV FA K L
Sbjct: 1 MIEALNEKGVSHVVTPLLNVQA-TDIQLHQSSIEQFNQADIVIFISTNAVKFASKALNNQ 59
Query: 75 GFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNAMQDLSDKTVLILRG 134
+ ++ VG+ T Q A P + +EGLL L + +S+K ++I+RG
Sbjct: 60 ---FPDSAQFYAVGEATYQALLALGISSQKAPQECQQTEGLLTLEQLHHISNKNIVIVRG 116
Query: 135 NGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRAGIQTIVVTSAEILTQLV 194
GGRE AE RGA V E Y+R + + A I TIVVTS EIL L+
Sbjct: 117 VGGREALAEALTSRGAIVNYWEAYQRGCPQLDKNSVIQGWQNAEIDTIVVTSGEILNNLI 176
Query: 195 DFVPQNEHNWLKSCQLITVSERIAHLAEALGWQNVVISPRADNQTLLQTL 244
VP+ WL++C +I S R+ A A G Q+V + A+ + +L L
Sbjct: 177 KLVPKELFAWLRACHIIVPSSRVQEQALANGLQHVTNAKAANCKAVLSAL 226
>gi|71909285|ref|YP_286872.1| Uroporphyrinogen III synthase HEM4 [Dechloromonas aromatica RCB]
gi|71848906|gb|AAZ48402.1| Uroporphyrinogen III synthase HEM4 [Dechloromonas aromatica RCB]
Length = 260
Score = 103 bits (256), Expect = 1e-20, Method: Composition-based stats.
Identities = 74/236 (31%), Positives = 117/236 (49%), Gaps = 3/236 (1%)
Query: 3 VLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVSKS 62
++VTRP + L + +A AG + PL I + L A+L++ +S +
Sbjct: 12 IVVTRPQAQAAPLAEAIAAAGGKPLVFPLLEISPATDPQPLIEAVARLESYSLAVFISPN 71
Query: 63 AVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNAM- 121
AVD A + A G W L VGQGTA+ A P+ + +SE LL+L M
Sbjct: 72 AVDHALPAILAHGG-WPVSLKPAAVGQGTARELAAKGVFGCVVPSERFDSEALLELPEMA 130
Query: 122 -QDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRAGIQ 180
+ ++ + V+I RG+GGREL A+ ++RGA+V+ + CYRR + + +
Sbjct: 131 AESVNGRRVVIFRGDGGRELLADTLRERGASVDCITCYRRSGPSAGVQPLLAAWQSGQLD 190
Query: 181 TIVVTSAEILTQLVDFVPQNEHNWLKSCQLITVSERIAHLAEALGWQNVVISPRAD 236
+ V+S+E L LVD + +L+ L RIA A ALG N++++ AD
Sbjct: 191 ALTVSSSEGLRYLVDRLDAEGRAFLQKTPLFVPHARIAENARALGLSNIILTEAAD 246
>gi|114331037|ref|YP_747259.1| Uroporphyrinogen-III synthase [Nitrosomonas eutropha C91]
gi|114308051|gb|ABI59294.1| Uroporphyrinogen-III synthase [Nitrosomonas eutropha C91]
Length = 260
Score = 102 bits (255), Expect = 2e-20, Method: Composition-based stats.
Identities = 71/245 (28%), Positives = 115/245 (46%), Gaps = 2/245 (0%)
Query: 2 AVLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVSK 61
++L+TRP + L + G P+ I L + A+L + D VS
Sbjct: 10 SILITRPLHQAGNLAARIKGLGGEPWLFPVLEISDSENKQPLLDMIARLDDFDLAVFVSP 69
Query: 62 SAVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNAM 121
+AV+ + A W + TVG+G+A+ V P +SE LL++ +
Sbjct: 70 NAVERVMPLVHAER-RWPEHVRVATVGKGSARALEHHGIPAVIVPEDGSDSEALLRVPQL 128
Query: 122 QDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRAGIQT 181
Q + K ++I RGNGGR+L + + RGA+V+ VECYRR + GIQ
Sbjct: 129 QIMQGKRIIIFRGNGGRKLLGDTLRDRGASVDYVECYRRHRPEVDPLPLLKYWHDNGIQA 188
Query: 182 IVVTSAEILTQLVDFVPQNEHNWLKSCQLITVSERIAHLAEALGWQNVVISPRADNQTLL 241
+V++S+E L L D + + L++ + T +RI A LG + + +P D T +
Sbjct: 189 VVISSSEGLDNLFDMIGKTGQQLLRATAVFTAHDRIECKARELGIRKIYRTPLGDEGT-V 247
Query: 242 QTLLQ 246
Q LL+
Sbjct: 248 QGLLE 252
>gi|88705503|ref|ZP_01103213.1| Uroporphyrinogen-III synthase [gamma proteobacterium KT 71]
gi|88700016|gb|EAQ97125.1| Uroporphyrinogen-III synthase [Congregibacter litoralis KT71]
Length = 261
Score = 102 bits (254), Expect = 2e-20, Method: Composition-based stats.
Identities = 71/231 (30%), Positives = 112/231 (48%), Gaps = 8/231 (3%)
Query: 3 VLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELP----NKFAKLKNGDYVFA 58
VLVTRP + L+ L+ AG V +HLP+ +IE L+ LP + L +V
Sbjct: 7 VLVTRPAGQADSLIGALSDAGFVPLHLPMLQIEP---LDPLPGAQRQRLMDLDRYAHVIF 63
Query: 59 VSKSAVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQL 118
VS +A + + Y+ VG+ TA A + V P +SEGLL +
Sbjct: 64 VSANAARLGVERIRDYWPQLPQGQLYWAVGKSTALCLEAEG-LDVRRPERDMSSEGLLAM 122
Query: 119 NAMQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRAG 178
+ +L + VLI++G GGR+ + ++RGA V+ + CYRR+ ++ +
Sbjct: 123 PGLAELQSQRVLIVKGEGGRKFLEVKLRERGAEVDSLACYRRDYAAHDRQACRDLLGDHD 182
Query: 179 IQTIVVTSAEILTQLVDFVPQNEHNWLKSCQLITVSERIAHLAEALGWQNV 229
+ I+V+S E L +L + EH L L+ S+R+A A LGW +V
Sbjct: 183 LALILVSSGEGLERLTSLLQPEEHTNLAMTTLLVPSQRVAEQALGLGWTHV 233
>gi|82703802|ref|YP_413368.1| Uroporphyrinogen-III synthase [Nitrosospira multiformis ATCC 25196]
gi|82411867|gb|ABB75976.1| Uroporphyrinogen-III synthase [Nitrosospira multiformis ATCC 25196]
Length = 260
Score = 102 bits (253), Expect = 3e-20, Method: Composition-based stats.
Identities = 72/237 (30%), Positives = 112/237 (47%), Gaps = 3/237 (1%)
Query: 3 VLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVSKS 62
+LVTRP + L + AG P+ I+ ++ L +L VS +
Sbjct: 10 ILVTRPSHQAGGLAGKIRAAGGEPCLFPVLEIQDISDPRPLLELIERLDEFYLAIFVSPN 69
Query: 63 AVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNAMQ 122
AV+ A + A + DL TVGQGTA+ V P + +SE LL + +
Sbjct: 70 AVNKAMSVICAKRAL-PSDLKIATVGQGTARTLRRFGVSGVIVPAVRFDSEALLDMAELD 128
Query: 123 --DLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRAGIQ 180
+++ K ++I RG+ GREL E ++RGA+VE ECYRR + R +
Sbjct: 129 RINVAGKRIIIFRGDNGRELLGETLRKRGASVEYAECYRRIRPEAEIGPLLAAWTRGEMN 188
Query: 181 TIVVTSAEILTQLVDFVPQNEHNWLKSCQLITVSERIAHLAEALGWQNVVISPRADN 237
+ VTS+E L L + V + WL++ L ERIA +A LG+ V+++ D+
Sbjct: 189 GVTVTSSEGLRNLWEMVGDSGRTWLENTPLFVSHERIAGVARKLGFNRVIVTAAGDD 245
>gi|91774390|ref|YP_544146.1| Uroporphyrinogen-III synthase [Methylobacillus flagellatus KT]
gi|91708377|gb|ABE48305.1| Uroporphyrinogen-III synthase [Methylobacillus flagellatus KT]
Length = 256
Score = 100 bits (248), Expect = 1e-19, Method: Composition-based stats.
Identities = 72/246 (29%), Positives = 111/246 (45%), Gaps = 6/246 (2%)
Query: 3 VLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVSKS 62
+ +TRP ++ +L M+ AG AI PL I + + ++ D++ +S +
Sbjct: 9 IAITRPLDQATRLTSMIEAAGGHAIGFPLIAIAPLQDYSSFEQTLDEVTMQDWLIFISSN 68
Query: 63 AVDFAFKTLTATGFVWRHDLHYFT-VGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNAM 121
AV A L A W F +G TA V P + +SE LL L M
Sbjct: 69 AVQHAMSRLQAKLPQWPPAKPQFAAIGPVTASQLMQYGITNVLQPEHRFDSESLLALPQM 128
Query: 122 QDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRAGIQT 181
Q + ++I+RG GGREL A+ + RGA V ECYRR + + S+ + T
Sbjct: 129 QAVKGLRIMIVRGVGGRELMADTLRDRGAEVRFAECYRRINPQADAGKLQSLWHNGQLDT 188
Query: 182 IVVTSAEILTQLVDFVPQNEHNWLKSCQLITVSERIAHLAEALGWQNVVISPRADNQTLL 241
IVVTS+E + L+ WL+ + RIA L +LG + ++ S D+
Sbjct: 189 IVVTSSEAMRNLLAMTGSGTAEWLRDITICVNHARIAELPSSLGLRVLIASAPGDD---- 244
Query: 242 QTLLQC 247
++QC
Sbjct: 245 -AMMQC 249
>gi|71279895|ref|YP_266841.1| uroporphyrinogen-III synthase [Colwellia psychrerythraea 34H]
gi|71145635|gb|AAZ26108.1| uroporphyrinogen-III synthase [Colwellia psychrerythraea 34H]
Length = 253
Score = 99.8 bits (247), Expect = 1e-19, Method: Composition-based stats.
Identities = 85/253 (33%), Positives = 126/253 (49%), Gaps = 20/253 (7%)
Query: 1 MAVLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVS 60
+ VL+TRP + QQL +L + G++ LF + A N++ L+N D + VS
Sbjct: 6 LKVLITRPKAKAQQLALLLNQQGILNTSQTLFDYQKNASANDIATA---LENADILIFVS 62
Query: 61 KSAVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPV-HYPTAQENSEGLLQLN 119
+AV+FA + + + F VG T + A + P QE+SEGLL+L
Sbjct: 63 VAAVEFAHASYPLPNNLSQT---IFAVGNATKKALQAIGMTTILSPPPQQEHSEGLLKLP 119
Query: 120 AMQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRRE----PIVYNNAEQTSICK 175
+ + K ++I RGNGGRE A RGA V +E Y+R PI+ AEQ K
Sbjct: 120 QLSKVIGKRIIIFRGNGGREHIANSLTLRGAEVRYIESYQRVWRTLPIII--AEQWRAQK 177
Query: 176 RAGIQTIVVTSAEILTQLVDFVPQNEHN----WLKSCQLITVSERIAHLAEALGWQNVVI 231
I IVVTS +IL L+ ++ ++ W C + VS+RI A+ALG + V+
Sbjct: 178 ---INCIVVTSNDILLALLKYLASTTNSTDNYWQSQCLWVVVSDRIEKNAKALGLKRVIN 234
Query: 232 SPRADNQTLLQTL 244
+ A +Q L TL
Sbjct: 235 THGASSQILCNTL 247
>gi|87118401|ref|ZP_01074300.1| uroporphyrinogen-III synthetase [Marinomonas sp. MED121]
gi|86166035|gb|EAQ67301.1| uroporphyrinogen-III synthetase [Marinomonas sp. MED121]
Length = 253
Score = 99.0 bits (245), Expect = 3e-19, Method: Composition-based stats.
Identities = 73/250 (29%), Positives = 125/250 (50%), Gaps = 11/250 (4%)
Query: 3 VLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNE-LPNKFAKLKNGDYVFAVSK 61
+L+TRP+ + G ++ LP+ I++ E N + + L D V +SK
Sbjct: 8 ILITRPEPENTLSCERFQTWGAHSLSLPMIEIDALTEQNAAIQSHIFDLDLYDQVIFISK 67
Query: 62 SAVDFAFKTLTATGFVWRHDLHYFTVGQGTAQY-----FTATTEMPVHYPTAQENSEGLL 116
+AV + + + + +++ +G+GT + F + H + SE LL
Sbjct: 68 NAVRYGIEWIEDCWPMLPVGINWVGIGKGTTDFINELGFDLGIKAQEH-ALSGNTSEALL 126
Query: 117 QLNAMQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKR 176
+MQ ++ + +LI+ G GGR AE +RGA V+ + Y R I Y + EQ + +
Sbjct: 127 NQESMQKVAGQKILIMGGEGGRTKLAETLLERGAQVKHLALYSRNKINY-DLEQ--VAEA 183
Query: 177 AGIQTIVVTSAEILTQLVDFVPQNEHNWLKSCQLITVSERIAHLAEALGWQNVVISPRAD 236
+ I++TS E L LVD + Q+ NWL ++T S+R+A +A LGW+NVV + AD
Sbjct: 184 ENCEVILITSGEGLENLVDTLSQHNKNWLHKL-ILTPSQRVADMAIELGWKNVVNANGAD 242
Query: 237 NQTLLQTLLQ 246
+ ++ L Q
Sbjct: 243 DNSIYAALTQ 252
>gi|30248605|ref|NP_840675.1| Uroporphyrinogen III synthase HEM4 [Nitrosomonas europaea ATCC
19718]
gi|30180200|emb|CAD84502.1| Uroporphyrinogen III synthase HEM4 [Nitrosomonas europaea ATCC
19718]
Length = 259
Score = 98.6 bits (244), Expect = 3e-19, Method: Composition-based stats.
Identities = 70/245 (28%), Positives = 112/245 (45%), Gaps = 2/245 (0%)
Query: 2 AVLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVSK 61
++L+TRP + L + + G P+ I L + A+L D VS
Sbjct: 12 SILITRPLHQAGGLATWVRELGGEPWLFPVLEISDSENKQPLLDLIARLDEFDLAVFVSP 71
Query: 62 SAVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNAM 121
+AV+ L W + TVG+G+A+ V P +SE LL++
Sbjct: 72 NAVEKVIP-LVQVSHSWPRHVLVATVGKGSARVLERYGITNVIVPEEGSDSEALLRMPQF 130
Query: 122 QDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRAGIQT 181
Q + + V+I RGN GR L + ++RGA+VE +ECYRR + + GIQ
Sbjct: 131 QVMQGRHVVIFRGNDGRRLLGDTLRERGASVEYIECYRRHKPEADPLPLLKHWRDDGIQA 190
Query: 182 IVVTSAEILTQLVDFVPQNEHNWLKSCQLITVSERIAHLAEALGWQNVVISPRADNQTLL 241
++++S+E L L D + + LK+ + T ERI A LG + + + D T +
Sbjct: 191 VIISSSEGLDNLFDMIGETGQQLLKATPVFTAHERIERKARELGIRKIYRTLLGDEGT-V 249
Query: 242 QTLLQ 246
Q LL+
Sbjct: 250 QGLLE 254
>gi|119897285|ref|YP_932498.1| HemD protein [Azoarcus sp. BH72]
gi|119669698|emb|CAL93611.1| HemD protein [Azoarcus sp. BH72]
Length = 265
Score = 98.2 bits (243), Expect = 4e-19, Method: Composition-based stats.
Identities = 75/246 (30%), Positives = 118/246 (47%), Gaps = 4/246 (1%)
Query: 3 VLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVSKS 62
V VTRP+ + L + + +AG + P+ I + + L A+L + D F VS +
Sbjct: 19 VAVTRPEAQALSLCEAIRRAGGQVLLFPVLAIGAVEDPAALDEAIARLDHFDLAFFVSPN 78
Query: 63 AVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNAMQ 122
AV+ A + A W L TVG+G+ + V P+ +SE +L L A
Sbjct: 79 AVEHALAAVKARRH-WPERLEVSTVGKGSERALREAGFSAVIAPSEGFDSEAVLALPAFS 137
Query: 123 D--LSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRAGIQ 180
++ + V+I RG+GGREL A+ + RGA VE V CYRR + A +
Sbjct: 138 ATAINGRRVVIFRGDGGRELLADALRARGAVVEQVSCYRRYRPAADAAPLIQAAGTGRLD 197
Query: 181 TIVVTSAEILTQLVDFVPQNEHNWLKSCQLITVSERIAHLAEALGWQNVVISPRADNQTL 240
+V+TS+E + LV+ V + L+ + RI A A G+ V +P D+ L
Sbjct: 198 ALVLTSSEGVRNLVEMVGEKGFGVLRRVTVFAPHPRIVAHARAAGFDRVEETPPGDD-GL 256
Query: 241 LQTLLQ 246
L+TL++
Sbjct: 257 LETLVR 262
>gi|119475319|ref|ZP_01615672.1| Uroporphyrinogen-III synthase [marine gamma proteobacterium
HTCC2143]
gi|119451522|gb|EAW32755.1| Uroporphyrinogen-III synthase [marine gamma proteobacterium
HTCC2143]
Length = 264
Score = 97.8 bits (242), Expect = 4e-19, Method: Composition-based stats.
Identities = 74/249 (29%), Positives = 113/249 (45%), Gaps = 9/249 (3%)
Query: 3 VLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIE-----SGAELNELPNKFAKLKNGDYVF 57
VLVTRP + LV + AG AIH P+ IE AE +F L +V
Sbjct: 9 VLVTRPQGQAADLVAAIETAGGCAIHCPVIAIERLSDSDTAEQQRCKQQFMALDQFQHVI 68
Query: 58 AVSKSAVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVH--YPTAQENSEGL 115
+S +AV + + + ++++ +G T Q +PV+ NSE L
Sbjct: 69 FISTNAVKYGLQWIDQYWPQLPVGINWYGIGGSTTQLLRQEG-VPVNDTVECGTMNSEAL 127
Query: 116 LQLNAMQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICK 175
LQ +Q S + VLI+RG GGR+ + QQRGA VE ECYRR V + + I +
Sbjct: 128 LQHKGLQAFSHQKVLIVRGVGGRDYLQQVLQQRGAEVEYAECYRRRVAVTSTDLISKIVE 187
Query: 176 RAGIQTIVVTSAEILTQLVDFVPQNEHNWLKSCQLITVSERIAHLAEALGWQNVVISPRA 235
I T+ + S E + V + +K L+ R+A +A G++ V + A
Sbjct: 188 YE-INTVCLNSGESVENFCQLVGPEHWSIIKGLLLVVPGARVAEIAGKKGFERVFCADNA 246
Query: 236 DNQTLLQTL 244
NQ ++ +
Sbjct: 247 SNQAMIAAI 255
>gi|148244914|ref|YP_001219608.1| uroporphyrinogen-III synthetase [Candidatus Vesicomyosocius
okutanii HA]
gi|146326741|dbj|BAF61884.1| uroporphyrinogen-III synthetase [Candidatus Vesicomyosocius
okutanii HA]
Length = 248
Score = 97.8 bits (242), Expect = 6e-19, Method: Composition-based stats.
Identities = 71/250 (28%), Positives = 125/250 (50%), Gaps = 19/250 (7%)
Query: 1 MAVLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVS 60
M V++TRP + ++L DM+ K+G + P + L+ + K K + D + +S
Sbjct: 1 MNVMLTRPALQVEKLQDMVVKSGNNPLFFPTLK------LHPIDIKLEK-NHYDVIIFIS 53
Query: 61 KSAVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNA 120
+AV++ K L + VG TA+ + + +P + +SE LL+L++
Sbjct: 54 ANAVEYGLKILKNISY-----QQVLAVGSATAKKLSENNIIINDFPKNKASSEALLELDS 108
Query: 121 MQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICK----R 176
+ L+DKT+LI RG GGRE + ++G VE VE Y R ++ S+ K R
Sbjct: 109 VTQLNDKTILIFRGKGGRETLKQGLIKQGNQVEYVEVYERVCCDISHLHCQSLDKFLLSR 168
Query: 177 AGIQTIVVTSAEILTQLVDFVPQNEH-NWLKSCQLITVSERIAHLAEALGWQNVVISPRA 235
G+ I +TS + + L+ V Q H + LK+ L+ +SERI ++ + V+++P
Sbjct: 169 EGV--ISITSIDNMKSLIKIVNQINHIDKLKNYLLVVLSERIKIYVNSIEFDKVLVTPNT 226
Query: 236 DNQTLLQTLL 245
N ++ L+
Sbjct: 227 SNNGIISVLM 236
>gi|118566870|gb|ABL01754.1| unknown [Salmonella enterica subsp. enterica serovar Typhi]
Length = 133
Score = 96.3 bits (238), Expect = 2e-18, Method: Composition-based stats.
Identities = 52/123 (42%), Positives = 68/123 (55%)
Query: 48 AKLKNGDYVFAVSKSAVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPT 107
A L D VFA+S+ +V FA L G W YF++G+ TA + + YP
Sbjct: 1 ATLTENDLVFALSQHSVAFAHAQLQRDGRNWPASPRYFSIGRTTALALHTVSGFDIRYPL 60
Query: 108 AQENSEGLLQLNAMQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNN 167
+E SE LLQL +Q+++ K LILRGNGGREL E RGA V ECY+R Y+
Sbjct: 61 DREISEALLQLPELQNIAGKRALILRGNGGRELLGETLTVRGAEVSFCECYQRCAKHYDG 120
Query: 168 AEQ 170
AE+
Sbjct: 121 AEE 123
>gi|67155437|ref|ZP_00417065.1| Uroporphyrinogen-III synthase [Azotobacter vinelandii AvOP]
gi|67087238|gb|EAM06705.1| Uroporphyrinogen-III synthase [Azotobacter vinelandii AvOP]
Length = 262
Score = 96.3 bits (238), Expect = 2e-18, Method: Composition-based stats.
Identities = 83/236 (35%), Positives = 108/236 (45%), Gaps = 15/236 (6%)
Query: 3 VLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVSKS 62
+L+TRP E L D L++AG+ + LPL IE AE EL + F L V VSK
Sbjct: 12 LLLTRPAEECAVLADCLSEAGICSSSLPLLAIEPLAEAPELRSLFLDLDRYSAVIVVSKP 71
Query: 63 AVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNAMQ 122
A + L D +F VG+ T + A + V +PTA E+SE LL L +
Sbjct: 72 AARLGLELLDRYWPQPPADQCWFGVGRATGEIL-ADYGLTVAWPTAGEDSEALLALPGLA 130
Query: 123 D---LSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNA---EQTSICKR 176
+ VLILRG GGRE AE + RG V+ VE YRR Y E+ +
Sbjct: 131 TALAVPQPRVLILRGEGGREFIAESLRSRGLAVDHVELYRRTLPDYPPGTLLERVRTERL 190
Query: 177 AGIQTIVVTSAEILTQLVDFVPQNEHNW--LKSCQLITVSERIAHLAEALGWQNVV 230
G+Q E L QL +W L L S R+A LA A G++ VV
Sbjct: 191 NGLQISSGQGFEHLRQLA------AADWPALLRIPLFVPSPRVAELARAAGFRTVV 240
>gi|85711586|ref|ZP_01042644.1| Uroporphyrinogen-III synthase [Idiomarina baltica OS145]
gi|85694738|gb|EAQ32678.1| Uroporphyrinogen-III synthase [Idiomarina baltica OS145]
Length = 241
Score = 95.5 bits (236), Expect = 3e-18, Method: Composition-based stats.
Identities = 68/245 (27%), Positives = 114/245 (46%), Gaps = 15/245 (6%)
Query: 4 LVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDY--VFAVSK 61
L+ +PD+ Q+++ L+++ + IE P L N DY V +SK
Sbjct: 8 LILQPDDSRQRIIGALSESAIQFTQHSFIDIE--------PISVKPLVNPDYDGVIWISK 59
Query: 62 SAVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNAM 121
+AV FA GF + F VG TA+ T + + PT + +SE LL L M
Sbjct: 60 NAVKFA----ADAGFRFLPQTSMFAVGPTTARLAANTFGISAYCPTYKHDSESLLTLPEM 115
Query: 122 QDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRAGIQT 181
++ ++ LI++G GR+L + + RGA V ++ YRR N+ Q + +
Sbjct: 116 VNVDNQKWLIIKGEKGRDLLFDTLRARGATVSSIDVYRRVKRPLNDETQVTQWMNT-VNL 174
Query: 182 IVVTSAEILTQLVDFVPQNEHNWLKSCQLITVSERIAHLAEALGWQNVVISPRADNQTLL 241
IVVTSAE L + +P+ WL C I SER+ L + + ++ A ++
Sbjct: 175 IVVTSAEQLGYFLSSLPREAGGWLSRCDWIVPSERLRDLIPFVAADTITVTGSATESKMI 234
Query: 242 QTLLQ 246
+ +++
Sbjct: 235 EAIIK 239
>gi|90406696|ref|ZP_01214889.1| uroporphyrinogen-III synthase [Psychromonas sp. CNPT3]
gi|90312149|gb|EAS40241.1| uroporphyrinogen-III synthase [Psychromonas sp. CNPT3]
Length = 241
Score = 95.1 bits (235), Expect = 3e-18, Method: Composition-based stats.
Identities = 69/239 (28%), Positives = 115/239 (48%), Gaps = 8/239 (3%)
Query: 3 VLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVSKS 62
+L+TR + +LV +L + GV ++ PL ++S AE +++ F + DY+ A+S +
Sbjct: 6 LLITRFEPHASRLVKLLNEQGVFSLAQPLLEVQSSAECHDVDLIF--VTRYDYIIAISAA 63
Query: 63 AVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNAMQ 122
AV + + L + + VG+ T + T+ V P Q +++GLL L +
Sbjct: 64 AVKYTEQALDKKAW---PTATFIAVGKRTQKMLQQATQKEVQCPPLQHDTQGLLALACLN 120
Query: 123 DLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRAGIQTI 182
+ K +LILRG GGR + + RGA V + Y+R I N E + I
Sbjct: 121 CVQGKKILILRGVGGRAKLKKTLESRGAEVSYYQPYQRVVIDLNMDELVENWQLHKINGA 180
Query: 183 VVTSAEILTQLVDFVPQNEHNWLKSCQLITVSERIAHLAEALGWQNVV-ISPRADNQTL 240
+++S E+L V + +WL L S+RI A LGW +V ++ AD Q +
Sbjct: 181 IISSIELLENFTTRV--RDKHWLYELHLYVPSQRILDRALQLGWVKIVLLASLADQQII 237
>gi|89093769|ref|ZP_01166715.1| uroporphyrinogen-III synthetase [Oceanospirillum sp. MED92]
gi|89081899|gb|EAR61125.1| uroporphyrinogen-III synthetase [Oceanospirillum sp. MED92]
Length = 260
Score = 94.7 bits (234), Expect = 4e-18, Method: Composition-based stats.
Identities = 68/256 (26%), Positives = 118/256 (46%), Gaps = 13/256 (5%)
Query: 1 MAVLVTRPDERGQQLVDMLAKAGVVAIHLPLFRI------ESGAELNELPNKFAKLKNGD 54
+ VLVTRP + L ++L + G + PL +I +SG L L + L
Sbjct: 8 LRVLVTRPAHQADTLYELLLQQGADPVRFPLLQITPVTSADSGFHL--LKQQIIDLDLFQ 65
Query: 55 YVFAVSKSAVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEG 114
++ +S +AV+ ++ + + + +G+ +A H P + SE
Sbjct: 66 HIIFISPNAVELGYEWIDQYWPQLPLGVQWLAIGKQSAARLNNYGIDAYHSPLGYD-SEA 124
Query: 115 LLQLNAMQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSIC 174
LL A+Q ++ VLI+RG GGRE AE+ + RGA V E YRRE Y+ E +
Sbjct: 125 LLNSPALQKIAGDKVLIMRGEGGRETLAEELRARGAEVSYAELYRRESPCYSAKEISDAL 184
Query: 175 KRAGIQTIVVTSAEILTQLVDFVPQN----EHNWLKSCQLITVSERIAHLAEALGWQNVV 230
+ I+++S L L+ + + L +C LI S+RI A+ +G+ +
Sbjct: 185 LSKHLDAILISSGAGLKNLITLLSSTGKELSTDSLLNCHLIVPSDRIKQEAQGVGFNRIT 244
Query: 231 ISPRADNQTLLQTLLQ 246
+ D+++++ L Q
Sbjct: 245 TASGPDDRSMIAALTQ 260
>gi|152997594|ref|YP_001342429.1| Uroporphyrinogen III synthase HEM4 [Marinomonas sp. MWYL1]
gi|150838518|gb|ABR72494.1| Uroporphyrinogen III synthase HEM4 [Marinomonas sp. MWYL1]
Length = 250
Score = 94.4 bits (233), Expect = 5e-18, Method: Composition-based stats.
Identities = 71/244 (29%), Positives = 118/244 (48%), Gaps = 11/244 (4%)
Query: 3 VLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKL---KNGDYVFAV 59
+L+TRP+ + + G VA+ LP+ I+ ++N+ A++ DYV V
Sbjct: 6 ILITRPEPENSLSRERVRAYGWVAVPLPMLEIKPVEDVNKKATIRAQIFDIDTFDYVIFV 65
Query: 60 SKSAVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLN 119
SK+A A L + ++H+ +GQGT Q T E +E LL+
Sbjct: 66 SKNAARLACDWLDECWPMIPTNVHWIGIGQGTTQ--TLLNEGIPAISNPGHTTETLLEWL 123
Query: 120 AMQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECY-RREPIVYNNAEQTSICKRAG 178
+ D+ VLI+RG GGR A + ++RGA V + Y R++PI Y +
Sbjct: 124 KPAKMKDQKVLIIRGEGGRPELANKLEERGAKVSYLSLYDRKKPIYY----AQTFFMLPD 179
Query: 179 IQTIVVTSAEILTQLVDFVPQNEHNWLKSCQLITVSERIAHLAEALGWQNVVISPRADNQ 238
I I +TS E L L ++V ++ W K+ ++T S R+ A+ +GW N + AD+
Sbjct: 180 INLIWITSGESLRNLSEYVSLHKPEW-KTLPILTPSIRVNQQAKEMGWINASCANGADDN 238
Query: 239 TLLQ 242
+L++
Sbjct: 239 SLIK 242
>gi|121997817|ref|YP_001002604.1| Uroporphyrinogen III synthase HEM4 [Halorhodospira halophila SL1]
gi|121589222|gb|ABM61802.1| Uroporphyrinogen III synthase HEM4 [Halorhodospira halophila SL1]
Length = 264
Score = 92.8 bits (229), Expect = 2e-17, Method: Composition-based stats.
Identities = 67/220 (30%), Positives = 97/220 (44%), Gaps = 1/220 (0%)
Query: 2 AVLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVSK 61
V+VTRP + + LV L AG P I + E + D++ VS+
Sbjct: 9 GVIVTRPTHQAEGLVHALEAAGAGVWRFPTLDIIAEPEDAARQEAARRAACADWLIFVSQ 68
Query: 62 SAVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNAM 121
+AV + A G H TVGQGTA+ V YP SE LL +
Sbjct: 69 NAVAHGLPRIRAAGGPAGH-ARCATVGQGTAEALRRNGIEEVLYPRHGATSEDLLAETDL 127
Query: 122 QDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRAGIQT 181
+S V+I+RG GGR AE + RGA V+ +E YRR + A + +Q
Sbjct: 128 GRISAGRVMIVRGVGGRPYLAEALRARGAEVDFLEVYRRVRPSTDPAPLLEAAEADRVQV 187
Query: 182 IVVTSAEILTQLVDFVPQNEHNWLKSCQLITVSERIAHLA 221
+V TS E+L ++ V WL ++ + ER+A +A
Sbjct: 188 VVATSGEVLDNFLELVGDRGRRWLARAGVVVIGERVATMA 227
>gi|152989208|ref|YP_001351321.1| uroporphyrinogen-III synthetase [Pseudomonas aeruginosa PA7]
gi|150964366|gb|ABR86391.1| uroporphyrinogen-III synthetase [Pseudomonas aeruginosa PA7]
Length = 251
Score = 92.4 bits (228), Expect = 2e-17, Method: Composition-based stats.
Identities = 77/238 (32%), Positives = 111/238 (46%), Gaps = 20/238 (8%)
Query: 3 VLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDY---VFAV 59
+L+TRP+E L L +AGV LPL I+ L E P + A + + D V V
Sbjct: 6 LLLTRPEEECAALAATLGEAGVHCSSLPLLAIDP---LEETPEQRALMLDLDRYCAVLVV 62
Query: 60 SKSAVDFAFKTLTATGFVWRHDLH--YFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQ 117
SK A + L W +F+VG TA + V YP ++SE LL
Sbjct: 63 SKPAARLGLERLDR---YWPQPPQQAWFSVGAATAAILE-DYGLCVTYPEQGDDSEALLA 118
Query: 118 LNAMQD---LSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSIC 174
L+A QD + D VLI+RG GGRE AE+ + +G V+ + YRR Y E +
Sbjct: 119 LSAFQDSLRVHDPKVLIMRGEGGREFLAERLRGQGVQVDYLPLYRRRAPEYPPGEPLARV 178
Query: 175 KRAGIQTIVVTSAEILTQLVDFVPQNEHNWLKSCQ--LITVSERIAHLAEALGWQNVV 230
+ + +VV+S + L L +W + C+ L S R+A +A LG Q V+
Sbjct: 179 RAERLNGLVVSSGQGLQNLYQLAAA---DWPEICRLPLFVPSPRVAEMARELGAQRVI 233
>gi|91782421|ref|YP_557627.1| Uroporphyrinogen III synthase HEM4 [Burkholderia xenovorans LB400]
gi|91686375|gb|ABE29575.1| Uroporphyrinogen III synthase HEM4 [Burkholderia xenovorans LB400]
Length = 672
Score = 90.9 bits (224), Expect = 6e-17, Method: Composition-based stats.
Identities = 84/266 (31%), Positives = 127/266 (47%), Gaps = 29/266 (10%)
Query: 3 VLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVSKS 62
V++TRP + +L+ LA AG+ + PL + + L + L+ V VS +
Sbjct: 20 VVITRPAGQSNELIARLAAAGIATLDFPLIDVAPVTDEAPLRAALSSLERYALVVFVSPN 79
Query: 63 AVDFAFKTLTATGFVWRHDLHYFTVGQGTAQ-----------YFTATTEMPVHYPTAQEN 111
AVD+AF + +W H L VG G+ Q Y + TA+ +
Sbjct: 80 AVDYAF---ARSDTIWPHALPIGVVGPGSVQALARHGVTSPAYNVISPPSGTDEETARFD 136
Query: 112 SEGLLQ-----LNAMQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRR---EPI 163
SEGL L A +L K VLI+RG+GGRE AE+ ++ GA VE V YRR EP
Sbjct: 137 SEGLFAAIDTALGAT-NLEGKRVLIVRGDGGREWLAERLREAGAEVETVAAYRRLVPEPS 195
Query: 164 VYNNAEQTSICKRAGIQTIVVTSAEILTQL----VDFVPQNEHNWLKSCQLITVSERIAH 219
+ A + A ++TS+E + L D + +E + LK L+T RIA
Sbjct: 196 IGGWARVHELLAGAP-HAWLLTSSEGVRNLHELAQDHLTADEISQLKRAALVTPHPRIAQ 254
Query: 220 LAEALGWQNVVISPRADNQTLLQTLL 245
A ALG+ ++ +S D + +++TLL
Sbjct: 255 TARALGFDSITVSGAGD-ERIVRTLL 279
>gi|104784254|ref|YP_610752.1| uroporphyrinogen III synthase [Pseudomonas entomophila L48]
gi|95113241|emb|CAK17969.1| uroporphyrinogen III synthase [Pseudomonas]
Length = 255
Score = 90.9 bits (224), Expect = 6e-17, Method: Composition-based stats.
Identities = 78/233 (33%), Positives = 108/233 (46%), Gaps = 10/233 (4%)
Query: 3 VLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVSKS 62
+L+TRP+E L LA AG+ + LPL IE A + A++ + VSK
Sbjct: 6 LLLTRPEEDCAALAQSLADAGIASASLPLLAIEPVALEPRQQERLAEIGQAQAIIVVSKP 65
Query: 63 AVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQ---LN 119
A + L G H +FTVG+ TA A + V +PT ++SE LL L
Sbjct: 66 AARLLLEQLDQAGVEPPH-AGWFTVGEATAGVLQARGLL-VTFPTEGDDSEALLAHPFLR 123
Query: 120 AMQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRAGI 179
L VLI+RG GGREL AE+ ++GA+V+ +E YRR Y T +
Sbjct: 124 QAIALPTSRVLIVRGVGGRELLAERLAEQGASVDYLELYRRCLPHYPAGTLTQCIDGERL 183
Query: 180 QTIVVTSAEILTQLVDFVPQNEHNW--LKSCQLITVSERIAHLAEALGWQNVV 230
+VV+S + L L +W L L S R+A A ALG + VV
Sbjct: 184 NGLVVSSGQGLEHLHQLAGT---DWPRLSRLPLFVPSPRVADQARALGAREVV 233
>gi|146305322|ref|YP_001185787.1| Uroporphyrinogen III synthase HEM4 [Pseudomonas mendocina ymp]
gi|145573523|gb|ABP83055.1| Uroporphyrinogen III synthase HEM4 [Pseudomonas mendocina ymp]
Length = 257
Score = 90.9 bits (224), Expect = 7e-17, Method: Composition-based stats.
Identities = 80/240 (33%), Positives = 106/240 (44%), Gaps = 22/240 (9%)
Query: 3 VLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVSKS 62
+L+TRP E L LA+ G+ +PL IE E E FA+L+ V VSK
Sbjct: 6 LLLTRPAEDCAALAQTLAEHGITGSCMPLLGIEPLPETAEQRIAFAELQRYCAVIVVSKP 65
Query: 63 AVDFAFKTLTA------TGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLL 116
A L TG W F VG TA T +PVHYP ++SE LL
Sbjct: 66 AARLGLALLDGHRAEPVTGQPW------FAVGAATAALLTEHG-LPVHYPERGDDSEALL 118
Query: 117 QLNAMQDL----SDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTS 172
L A+Q S VLILRG GGRE + + +GA+V+ + YRR Y E +
Sbjct: 119 ALPALQGALAAESAPRVLILRGEGGREFLGQCLRGQGASVDYLPLYRRVLPPYPAGELSR 178
Query: 173 ICKRAGIQTIVVTSAEILTQLVDFVPQNEHNW--LKSCQLITVSERIAHLAEALGWQNVV 230
+ + +VV+S + L+ +W L L S R+A A A G Q VV
Sbjct: 179 RVQAERLNGLVVSSGQGFEHLLQLAGD---DWPALARLPLFVPSPRVAEQARAAGAQIVV 235
>gi|110835182|ref|YP_694041.1| uroporphyrinogen-III synthase [Alcanivorax borkumensis SK2]
gi|110648293|emb|CAL17769.1| uroporphyrinogen-III synthase [Alcanivorax borkumensis SK2]
Length = 243
Score = 89.7 bits (221), Expect = 1e-16, Method: Composition-based stats.
Identities = 66/243 (27%), Positives = 112/243 (46%), Gaps = 15/243 (6%)
Query: 3 VLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVSKS 62
V+VTRP+ + Q+L+ +L +AG +H P IE + + +L VF S +
Sbjct: 10 VVVTRPEGQQQRLMGLLVEAGYQPLHQPALVIEPITVDDTMQRTLMELDGYHAVFFASVN 69
Query: 63 AVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNAMQ 122
A A + W +H+ VG+ TA + +P P N+E +L L +Q
Sbjct: 70 AARLALSAMADLWPQWPVGVHWLAVGRATAAELE-SWHLPATVPQQGFNTEAVLALPCLQ 128
Query: 123 DLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRAGIQTI 182
L +K +LI RG+ GREL A+ Q RGA V+ + YRR+ + + A +
Sbjct: 129 QLVEKQILICRGDSGRELLAQTLQSRGARVDALAFYRRKA-------ASPVLIPAETDWV 181
Query: 183 VVTSAEILTQLVDFVPQNEHNWLKSCQLITVSERIAHLAEALGWQNVVISPRADNQTLLQ 242
++TS + + VP C ++ ER+A + A +V ++ A ++ +L
Sbjct: 182 MITSVQGWQAIGGSVP-------PCCGVVAAGERVADVVRAEHSGDVSVAASAHDEDMLS 234
Query: 243 TLL 245
L+
Sbjct: 235 ALV 237
>gi|34495507|ref|NP_899722.1| uroporphyrinogen-III synthetase [Chromobacterium violaceum ATCC
12472]
gi|34101363|gb|AAQ57732.1| uroporphyrinogen-III synthase [Chromobacterium violaceum ATCC
12472]
Length = 243
Score = 89.4 bits (220), Expect = 2e-16, Method: Composition-based stats.
Identities = 76/242 (31%), Positives = 105/242 (43%), Gaps = 10/242 (4%)
Query: 3 VLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVSKS 62
VL RP + L++ L G A HLPL IE E A D +F VS S
Sbjct: 4 VLAARPLAQCAGLLEKLRAEGWQAGHLPLMEIEPLPEALAALPAQAARA--DALFWVSPS 61
Query: 63 AVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNAMQ 122
A+D + L F + VG +A+ + PV +PTA +SE LL L +
Sbjct: 62 AIDVGWPALAGMDFSGKR---LACVGAASARRLADLSGRPVLHPTAGSDSEALLALPELA 118
Query: 123 DLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRAGIQTI 182
D S + LI+RG GGR L A+ RGA V + E YRR + A + A +
Sbjct: 119 DASGQRWLIVRGQGGRPLLADTLAARGAEVGVAEVYRR----VDGAPDWAAFDAAPPDAV 174
Query: 183 VVTSAEILTQLVDFVPQNEHNWLKSCQLITVSERIAHLAEALGWQNVVISPRADNQTLLQ 242
++TS E++ QL L+ RIA A G +V + RAD+ L+
Sbjct: 175 IITSGEMVEQLFRLAGPRRTGALQCLLYCVPHPRIAERLAAFGAARIVTT-RADDAALVA 233
Query: 243 TL 244
L
Sbjct: 234 GL 235
>gi|83749207|ref|ZP_00946209.1| UROPORPHYRINOGEN-III SYNTHASE / Uroporphyrin-III
C-methyltransferase [Ralstonia solanacearum UW551]
gi|83724148|gb|EAP71324.1| UROPORPHYRINOGEN-III SYNTHASE / Uroporphyrin-III
C-methyltransferase [Ralstonia solanacearum UW551]
Length = 1065
Score = 89.0 bits (219), Expect = 2e-16, Method: Composition-based stats.
Identities = 75/250 (30%), Positives = 114/250 (45%), Gaps = 15/250 (6%)
Query: 3 VLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVSKS 62
V+VTRP + LV L + G+ + PL I L++L A V VS +
Sbjct: 394 VVVTRPRAQALMLVAALERHGLRTLQFPLLDIAPTPNLDDLRAALADPSRYALVVFVSPN 453
Query: 63 AVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMP---------VHYPTAQENSE 113
AV AF + GF W D+ VG +AQ A P VH A+++SE
Sbjct: 454 AVQQAFAAM-PEGFRWPQDVPVAVVGPASAQALAAHGVEPPTHSVIRPDVHADDARQDSE 512
Query: 114 GLLQLNAMQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSI 173
L LS + VLI+RGNGGRE A++ ++ G V VE YRR V + A ++
Sbjct: 513 ALYARLDPAQLSGREVLIVRGNGGREWLADRLREAGVAVRTVEAYRRSVPVPDAAAWAAL 572
Query: 174 CK-RAGIQTIVVTSAEILTQLVDFVPQN----EHNWLKSCQLITVSERIAHLAEALGWQN 228
+ AG +TS+E + L + E + L + RI A++LG+++
Sbjct: 573 REVLAGRHAWTLTSSEAVRNLDSLARASLTAAEVDTLHAAPCFAPHARIVEQAQSLGFRD 632
Query: 229 VVISPRADNQ 238
V ++ D++
Sbjct: 633 VTLTGAGDDR 642
>gi|56476046|ref|YP_157635.1| uroporphyrinogen III synthase [Azoarcus sp. EbN1]
gi|56312089|emb|CAI06734.1| Uroporphyrinogen III synthase [Azoarcus sp. EbN1]
Length = 257
Score = 89.0 bits (219), Expect = 2e-16, Method: Composition-based stats.
Identities = 68/232 (29%), Positives = 109/232 (46%), Gaps = 8/232 (3%)
Query: 3 VLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIES--GAELNELPNKFAKLKNGDYVFAVS 60
V VTRP + L + +A G + + P+ I + GA L+++ + + D F VS
Sbjct: 13 VAVTRPVGQADSLCEAIAARGGIPVCFPVLAIGAVDGARLDDIATRLDQF---DLAFFVS 69
Query: 61 KSAVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNA 120
+AV A + A W + TVG+G+ + A V P + +SE +L L
Sbjct: 70 PNAVQHALTPILARR-AWPQRVVVATVGKGSERALAAFGFRSVVAPASGFDSESVLALPE 128
Query: 121 M--QDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRAG 178
+ + + ++I RG+GGR+L E ++ GA+VE V CYRR + A + +R
Sbjct: 129 FRPEAVRGRRIVIFRGDGGRDLLGETLREHGADVEYVSCYRRFQPDQDPAPLLDLARRGA 188
Query: 179 IQTIVVTSAEILTQLVDFVPQNEHNWLKSCQLITVSERIAHLAEALGWQNVV 230
+ I +TS+E + +LV V L + RIA A A G+ VV
Sbjct: 189 LDAITLTSSEGVAKLVAIVGAEGLRLLCPVPIFAPHSRIAAHARAAGFVRVV 240
>gi|15600452|ref|NP_253946.1| uroporphyrinogen-III synthetase [Pseudomonas aeruginosa PAO1]
gi|84324036|ref|ZP_00972101.1| COG1587: Uroporphyrinogen-III synthase [Pseudomonas aeruginosa
2192]
gi|107104361|ref|ZP_01368279.1| hypothetical protein PaerPA_01005436 [Pseudomonas aeruginosa PACS2]
gi|116053407|ref|YP_793732.1| uroporphyrinogen-III synthase [Pseudomonas aeruginosa UCBPP-PA14]
gi|12644664|sp|P48246|HEM4_PSEAE Uroporphyrinogen-III synthase (UROS) (Uroporphyrinogen-III
cosynthetase) (Hydroxymethylbilane hydrolyase
[cyclizing])
gi|9951570|gb|AAG08644.1|AE004938_6 uroporphyrinogen-III synthetase [Pseudomonas aeruginosa PAO1]
gi|115588628|gb|ABJ14643.1| uroporphyrinogen-III synthase [Pseudomonas aeruginosa UCBPP-PA14]
gi|126197235|gb|EAZ61298.1| uroporphyrinogen-III synthetase [Pseudomonas aeruginosa 2192]
Length = 251
Score = 87.8 bits (216), Expect = 5e-16, Method: Composition-based stats.
Identities = 75/235 (31%), Positives = 104/235 (44%), Gaps = 14/235 (5%)
Query: 3 VLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVSKS 62
+L+TRPDE L L +AGV + LPL I+ E E L V VSK
Sbjct: 6 LLLTRPDEECAALAASLGEAGVHSSSLPLLAIDPLEETPEQRTLMLDLDRYCAVVVVSKP 65
Query: 63 AVDFAFKTLTATGFVWRHDLH--YFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNA 120
A + L W + +VG TA A + V YP ++SE LL L A
Sbjct: 66 AARLGLERLDR---YWPQPPQQTWCSVGAATAAILEAYG-LDVTYPEQGDDSEALLALPA 121
Query: 121 MQD---LSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRA 177
QD + D VLI+RG GGRE AE+ + +G V+ + YRR Y E + +
Sbjct: 122 FQDSLRVHDPKVLIMRGEGGREFLAERLRGQGVQVDYLPLYRRRAPDYPAGELLARVRAE 181
Query: 178 GIQTIVVTSAEILTQLVDFVPQNEHNW--LKSCQLITVSERIAHLAEALGWQNVV 230
+ +VV+S + L L +W + L S R+A +A LG Q V+
Sbjct: 182 RLNGLVVSSGQGLQNLYQLAAA---DWPEIGRLPLFVPSPRVAEMARELGAQRVI 233
>gi|109896671|ref|YP_659926.1| Uroporphyrinogen III synthase HEM4 [Pseudoalteromonas atlantica
T6c]
gi|109698952|gb|ABG38872.1| Uroporphyrinogen III synthase HEM4 [Pseudoalteromonas atlantica
T6c]
Length = 240
Score = 87.8 bits (216), Expect = 5e-16, Method: Composition-based stats.
Identities = 73/246 (29%), Positives = 117/246 (47%), Gaps = 18/246 (7%)
Query: 1 MAVLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAE-LNELPNKFAKLKNGDYVFAV 59
M VL+ RP+++ AG+ A+ + L ++ E L+ LP+ L +GD +
Sbjct: 1 MTVLIFRPEQKCAPSAARFITAGLPAVGVGLISTQASQEALSSLPSALGSLSSGDGIIVT 60
Query: 60 SKSAVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTAT---TEMPVHYPTAQENSEGLL 116
S L + F VG TAQ A +P+ PT +EGLL
Sbjct: 61 STVVSQL----LAQQRIELPNSATIFAVGSSTAQGLRAQGYDVTVPL-VPT----TEGLL 111
Query: 117 QLNAMQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKR 176
L+ +++++ TV+IL+G GGRE A+Q QRGA V + + Y+R I A Q ++
Sbjct: 112 ALSPLKEIAGHTVVILKGQGGREDLAQQLTQRGATVLLADIYQRIKIATPKATQEWQAEQ 171
Query: 177 AGIQTIVVTSAEILTQLVDFVPQNEHNWLKSCQLITVSERIAHLAEALGWQNVVISPRAD 236
I+ I+ TS EI+ + + WL+S I VS R +A G + + +S A
Sbjct: 172 --IRCIIATSGEIIDTAFEHF---DAKWLQSLPWIVVSPRTEQIAVKQGIKTIFVSDDAS 226
Query: 237 NQTLLQ 242
+Q L++
Sbjct: 227 DQALIR 232
>gi|496215|gb|AAA18908.1| uropprphyrinogen-III-synthase [Pseudomonas aeruginosa]
Length = 251
Score = 87.8 bits (216), Expect = 5e-16, Method: Composition-based stats.
Identities = 75/233 (32%), Positives = 106/233 (45%), Gaps = 10/233 (4%)
Query: 3 VLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVSKS 62
+L+TRPDE L L +AGV + LPL I+ E E L V VSK
Sbjct: 6 LLLTRPDEECAALAASLGEAGVHSSSLPLLAIDPLEETPEQRTLMLDLDRYCAVVVVSKP 65
Query: 63 AVDFAFKTLTATGFVWRHDLH--YFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNA 120
A + L W + +VG TA A + V YP ++SE LL L A
Sbjct: 66 AARLGLERLDR---YWPQPPQQTWCSVGAATAAILEAYG-LDVTYPEQGDDSEALLALPA 121
Query: 121 MQD---LSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRA 177
QD + D VLI+RG GGRE AE+ + +G V+ + YRR Y E + +
Sbjct: 122 FQDSLRVHDPKVLIMRGEGGREFLAERLRGQGVQVDYLPLYRRRAPDYPAGELLARVRAE 181
Query: 178 GIQTIVVTSAEILTQLVDFVPQNEHNWLKSCQLITVSERIAHLAEALGWQNVV 230
+ +VV+S + L + V V ++ + L S R+A +A LG Q V+
Sbjct: 182 RLNGLVVSSGQGLPKSVS-VGGSDWPEIGRLPLFVPSPRVAEMARELGAQRVI 233
>gi|49082228|gb|AAT50514.1| PA5259 [synthetic construct]
Length = 252
Score = 87.8 bits (216), Expect = 5e-16, Method: Composition-based stats.
Identities = 75/235 (31%), Positives = 104/235 (44%), Gaps = 14/235 (5%)
Query: 3 VLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVSKS 62
+L+TRPDE L L +AGV + LPL I+ E E L V VSK
Sbjct: 6 LLLTRPDEECAALAASLGEAGVHSSSLPLLAIDPLEETPEQRTLMLDLDRYCAVVVVSKP 65
Query: 63 AVDFAFKTLTATGFVWRHDLH--YFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNA 120
A + L W + +VG TA A + V YP ++SE LL L A
Sbjct: 66 AARLGLERLDR---YWPQPPQQTWCSVGAATAAILEAYG-LDVTYPEQGDDSEALLALPA 121
Query: 121 MQD---LSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRA 177
QD + D VLI+RG GGRE AE+ + +G V+ + YRR Y E + +
Sbjct: 122 FQDSLRVHDPKVLIMRGEGGREFLAERLRGQGVQVDYLPLYRRRAPDYPAGELLARVRAE 181
Query: 178 GIQTIVVTSAEILTQLVDFVPQNEHNW--LKSCQLITVSERIAHLAEALGWQNVV 230
+ +VV+S + L L +W + L S R+A +A LG Q V+
Sbjct: 182 RLNGLVVSSGQGLQNLYQLAAA---DWPEIGRLPLFVPSPRVAEMARELGAQRVI 233
>gi|84317871|ref|ZP_00966306.1| COG1587: Uroporphyrinogen-III synthase [Pseudomonas aeruginosa
C3719]
gi|126169975|gb|EAZ55486.1| uroporphyrinogen-III synthetase [Pseudomonas aeruginosa C3719]
Length = 251
Score = 87.8 bits (216), Expect = 6e-16, Method: Composition-based stats.
Identities = 75/235 (31%), Positives = 104/235 (44%), Gaps = 14/235 (5%)
Query: 3 VLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVSKS 62
+L+TRPDE L L +AGV + LPL I+ E E L V VSK
Sbjct: 6 LLLTRPDEECAALAASLGEAGVHSSSLPLLAIDPLEETPEQRTLMLDLDRYCAVVVVSKP 65
Query: 63 AVDFAFKTLTATGFVWRHDLH--YFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNA 120
A + L W + +VG TA A + V YP ++SE LL L A
Sbjct: 66 AARLGLERLDR---YWPQPPQQTWCSVGAATAAILEAYG-LDVTYPEQGDDSEALLALPA 121
Query: 121 MQD---LSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRA 177
QD + D VLI+RG GGRE AE+ + +G V+ + YRR Y E + +
Sbjct: 122 FQDSLRVHDPKVLIMRGEGGREFLAERLRGQGVQVDYLPLYRRRAPDYPAGELLARVRAE 181
Query: 178 GIQTIVVTSAEILTQLVDFVPQNEHNW--LKSCQLITVSERIAHLAEALGWQNVV 230
+ +VV+S + L L +W + L S R+A +A LG Q V+
Sbjct: 182 RLNGLVVSSGQGLQNLYQLAAA---DWPEIGRLPLFVPSPRVAKMARELGAQRVI 233
>gi|119503706|ref|ZP_01625788.1| hypothetical protein MGP2080_01246 [marine gamma proteobacterium
HTCC2080]
gi|119460214|gb|EAW41307.1| hypothetical protein MGP2080_01246 [marine gamma proteobacterium
HTCC2080]
Length = 660
Score = 87.0 bits (214), Expect = 9e-16, Method: Composition-based stats.
Identities = 76/250 (30%), Positives = 117/250 (46%), Gaps = 11/250 (4%)
Query: 1 MAVLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIES-GAELNELPNKFAKLKNGDYVFAV 59
+ ++TRP + L +L + GV PL I S E EL L GD +
Sbjct: 3 LTAVLTRPGGVVEPLQLVLEQRGVDTFVQPLINIASISVEHREL----ITLYPGDICIFI 58
Query: 60 SKSAVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLN 119
S +AV+ L + VG+ TA +A V P+ Q +SEGLL L+
Sbjct: 59 SVNAVEQGLSNLAPQ--LRELGCPILAVGRATASAISAAG-FDVSVPS-QADSEGLLGLD 114
Query: 120 AMQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQT-SICKRAG 178
+ + K V+I++G GGR L AE ++RGA+V CYRR+P + + +C+R
Sbjct: 115 ILHGVKGKQVVIVKGEGGRGLLAEALRERGADVVSYVCYRRDPTGIDAGQFCWQLCEREH 174
Query: 179 IQTIVVTSAEILTQLVDFVPQNEHNWLKSCQLITVSERIAHLAEALGWQNVVISPRADNQ 238
+ +S EI+ QL + + Q L +I S R+A +A LGW NV+ + A +
Sbjct: 175 V-VFQASSGEIVEQLTELLGQGGQPNLLDSPVIVPSGRVAKIAVGLGWTNVITAAGAGDD 233
Query: 239 TLLQTLLQCR 248
+ L + R
Sbjct: 234 SFLSAIEPLR 243
>gi|52842940|ref|YP_096739.1| uroporphyrinogen III methylase [Legionella pneumophila subsp.
pneumophila str. Philadelphia 1]
gi|52630051|gb|AAU28792.1| uroporphyrinogen III methylase [Legionella pneumophila subsp.
pneumophila str. Philadelphia 1]
Length = 250
Score = 85.9 bits (211), Expect = 2e-15, Method: Composition-based stats.
Identities = 59/236 (25%), Positives = 115/236 (48%), Gaps = 11/236 (4%)
Query: 1 MAVLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAE--LNELPNKFAKLKNGDYVFA 58
+ +L TRP E+ Q L + ++G + I P I + +N LP+ L + +
Sbjct: 8 LRILNTRPREQAQVLNKKIIESGGIPIDCPTMEIMASETNWINNLPD----LTSVNQAIF 63
Query: 59 VSKSAVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQE--NSEGLL 116
VS +AV + L + W + + +G+GT++ E + E +SE LL
Sbjct: 64 VSTNAVRYFMMELASKNINWPNSIRVTAIGKGTSRVLN---EFNIQVSDVPELPDSEHLL 120
Query: 117 QLNAMQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKR 176
LN++Q + ++T+L+++G GGR+L E +GA + ++ Y+R + S+ +
Sbjct: 121 TLNSLQQIRNQTILLVKGEGGRQLIEEYLMLKGAKLCLLSVYKRVMPAIDQEFINSLWRD 180
Query: 177 AGIQTIVVTSAEILTQLVDFVPQNEHNWLKSCQLITVSERIAHLAEALGWQNVVIS 232
+ I++TS + + L WL++ + +S+R+A +A G + ++IS
Sbjct: 181 DLVDIILLTSEQSIHNLFKMFSIEGQMWLQNKPCLVISDRLAKVASLFGIKKILIS 236
>gi|118032435|ref|ZP_01503884.1| protein of unknown function DUF513, hemX [Burkholderia phymatum
STM815]
gi|117981733|gb|EAU96122.1| protein of unknown function DUF513, hemX [Burkholderia phymatum
STM815]
Length = 792
Score = 85.5 bits (210), Expect = 3e-15, Method: Composition-based stats.
Identities = 81/271 (29%), Positives = 118/271 (43%), Gaps = 30/271 (11%)
Query: 1 MAVLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVS 60
+ V++TRP + + L L AGV + PL I + + L A L+ V VS
Sbjct: 134 LTVVLTRPAGQSEALARTLHDAGVATVEFPLIEIAATDDATPLRAALASLEKYALVVFVS 193
Query: 61 KSAVDFAFKTLTATGFVWRHDLHYFTVGQGT-AQYFTATTEMPVHY-----PTAQENSEG 114
+AVD+AF A +W H L VG G+ A E P + A +N +G
Sbjct: 194 PNAVDYAFANHDA---IWPHALPIGVVGPGSVAALAKHGVEAPAYQVISPGAAADDNGDG 250
Query: 115 L------LQLNAMQDLSD-----KTVLILRGNGGRELFAEQAQQRGANVEIVECYRR--- 160
L L D K VLI+RG+GGRE AE+ ++ GA VE V YRR
Sbjct: 251 ARFDSEALYSALEASLGDNAFEGKRVLIVRGDGGREWLAERLREAGAEVETVAAYRRLVP 310
Query: 161 EPI------VYNNAEQTSICKRAGIQTIVVTSAEILTQLVDFVPQNEHNWLKSCQLITVS 214
EP ++ TS + A + T + + D + +E LK +
Sbjct: 311 EPSIGAWSRIHALLSDTSTARHAWLLTSSEGARNLAELAHDHLTNSEQTHLKRAMFVAPH 370
Query: 215 ERIAHLAEALGWQNVVISPRADNQTLLQTLL 245
RIA A ALG+ ++ +S D + + +TLL
Sbjct: 371 PRIAETARALGFDSITVSGAGD-ERIARTLL 400
>gi|54298728|ref|YP_125097.1| Uroporphyrinogen-III synthetase [Legionella pneumophila str. Paris]
gi|53752513|emb|CAH13945.1| Uroporphyrinogen-III synthetase [Legionella pneumophila str. Paris]
Length = 250
Score = 85.1 bits (209), Expect = 3e-15, Method: Composition-based stats.
Identities = 59/234 (25%), Positives = 111/234 (47%), Gaps = 7/234 (2%)
Query: 1 MAVLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVS 60
+ +L TRP E+ Q L + ++G + I P I A N N L + + VS
Sbjct: 8 LRILNTRPREQAQVLNKKIIESGGIPIDCPTMEIM--ASENNWINNLPDLTSVNQAIFVS 65
Query: 61 KSAVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQE--NSEGLLQL 118
+AV + L + W + + +G+GT++ E + E +SE LL L
Sbjct: 66 ANAVRYFMMELASKNINWLNSIRVAAIGKGTSRVLN---EFNIQVSDVPELPDSEHLLTL 122
Query: 119 NAMQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRAG 178
N++Q + ++T+L+++G GGR+L E +GA + ++ Y+R + S+ +
Sbjct: 123 NSLQQIRNQTILLVKGEGGRQLIEEYLMLKGAKLCLLSVYKRVMPTIDQEFLNSLWRDDL 182
Query: 179 IQTIVVTSAEILTQLVDFVPQNEHNWLKSCQLITVSERIAHLAEALGWQNVVIS 232
I++TS + + L WL++ + +S+R+A +A G + ++IS
Sbjct: 183 ADIILLTSEQSIHNLFKMFSIEGQMWLQNKPCLVISDRLAKVASLFGIKKILIS 236
>gi|118602826|ref|YP_904041.1| Uroporphyrinogen III synthase HEM4 [Candidatus Ruthia magnifica
str. Cm (Calyptogena magnifica)]
gi|118567765|gb|ABL02570.1| Uroporphyrinogen III synthase HEM4 [Candidatus Ruthia magnifica
str. Cm (Calyptogena magnifica)]
Length = 248
Score = 85.1 bits (209), Expect = 3e-15, Method: Composition-based stats.
Identities = 69/251 (27%), Positives = 122/251 (48%), Gaps = 23/251 (9%)
Query: 1 MAVLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNG--DYVFA 58
M VL+TRP + ++L M+ K+G + P ++ S AK++N D +
Sbjct: 1 MNVLLTRPLLQVEELQSMVTKSGNKPLLFPTLKLNSID---------AKVENNYYDVIIF 51
Query: 59 VSKSAVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQL 118
+S +AV++ K L + H + F VG TA+ + +P + +SE LL L
Sbjct: 52 ISVNAVEYGLKILKTISY---HKI--FAVGSATARKLSENDIEIDDFPRKKASSEALLAL 106
Query: 119 NAMQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTS----IC 174
+++ L KT+LI RG GRE+ + ++ VE VE Y R N+ + S +
Sbjct: 107 DSVAQLYHKTILIFRGQSGREVLKQGLIKQNNQVEYVEVYERVNHNINSLHRQSLDELLS 166
Query: 175 KRAGIQTIVVTSAEILTQLVDFVPQN-EHNWLKSCQLITVSERIAHLAEALGWQNVVISP 233
+ G+ I +TS + + LV Q + + LK+ L+ +S+RI ++G+ V+++P
Sbjct: 167 RNEGV--ISITSIDSMKLLVKISSQILDVDRLKNYLLVVLSDRIKTYVNSIGFNKVLVTP 224
Query: 234 RADNQTLLQTL 244
N ++ L
Sbjct: 225 NTSNNGIISVL 235
>gi|17547075|ref|NP_520477.1| uroporphyrinogen-III synthetase [Ralstonia solanacearum GMI1000]
gi|17429376|emb|CAD16063.1| probable bifunctional: uroporphyrin-III c-methyltransferase and
uroporphyrinogen-III synthase transmembrane protein
[Ralstonia solanacearum]
Length = 695
Score = 85.1 bits (209), Expect = 3e-15, Method: Composition-based stats.
Identities = 75/256 (29%), Positives = 113/256 (44%), Gaps = 15/256 (5%)
Query: 3 VLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVSKS 62
V+VTRP + LV L + G+ + PL I L++L A V VS +
Sbjct: 24 VIVTRPRAQAPMLVAALERHGLRTLQFPLLDIAPTPNLDDLRAALADPSRYALVVFVSPN 83
Query: 63 AVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTA---------TTEMPVHYPTAQENSE 113
AV AF + GF W D+ VG +AQ A H A+++SE
Sbjct: 84 AVQQAFAAM-PEGFRWPQDVPAAVVGPASAQALAAHGVAAPTYRVIRPDSHADDARQDSE 142
Query: 114 GLLQLNAMQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSI 173
L + LS + VLI+RGNGGRE A++ ++ G V VE YRR V + A ++
Sbjct: 143 ALYARLDVATLSGREVLIVRGNGGREWLADRLREAGVAVRTVEAYRRSVPVPDTAAWAAL 202
Query: 174 CK-RAGIQTIVVTSAEILTQLVDF----VPQNEHNWLKSCQLITVSERIAHLAEALGWQN 228
+ AG +TS+E L + E L + RI A++LG+++
Sbjct: 203 REVLAGRHAWTLTSSEAARNLDSLARASLSAAEVEALYAAPCFAPHARIVEQAQSLGFRD 262
Query: 229 VVISPRADNQTLLQTL 244
V ++ D++ L L
Sbjct: 263 VTLTGAGDDRLLAGVL 278
>gi|70733285|ref|YP_263059.1| uroporphyrinogen-III synthetase [Pseudomonas fluorescens Pf-5]
gi|68347584|gb|AAY95190.1| uroporphyrinogen-III synthase [Pseudomonas fluorescens Pf-5]
Length = 255
Score = 85.1 bits (209), Expect = 4e-15, Method: Composition-based stats.
Identities = 73/237 (30%), Positives = 109/237 (45%), Gaps = 18/237 (7%)
Query: 3 VLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVSKS 62
+L+TRP E L +LA++ +++ LPL I++ + V VSK
Sbjct: 6 LLLTRPAEDCAALAAILAQSEILSSSLPLLEIQALPVSDSQRATLLAFDQYCAVIVVSKP 65
Query: 63 AVDFAFKTLTATGFVWRH--DLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNA 120
A + L W D +FTVG TAQ A +PV YP ++SE LL+L
Sbjct: 66 AAHLGLELLRQ---YWPQPPDQAWFTVGAATAQIL-ADAGLPVAYPQQGDDSEALLELPQ 121
Query: 121 MQDL---SDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRA 177
+++ D VLI+RG GGREL +E+ + GA+V+ +E YRR Y +
Sbjct: 122 LREAIRRPDPRVLIVRGEGGRELLSERLRALGASVDYLELYRRCLPHYAEGALLQRIEVE 181
Query: 178 GIQTIVVTSAEILTQLVDFV----PQNEHNWLKSCQLITVSERIAHLAEALGWQNVV 230
+ +VV+S + + L PQ L L S R+A +A A G + VV
Sbjct: 182 RLNGLVVSSGQGFSHLRQLAGPAWPQ-----LAKMPLFVPSPRVADMAHAAGAEKVV 233
>gi|77164031|ref|YP_342556.1| Uroporphyrinogen III synthase HEM4 [Nitrosococcus oceani ATCC
19707]
gi|76882345|gb|ABA57026.1| Uroporphyrinogen III synthase HEM4 [Nitrosococcus oceani ATCC
19707]
Length = 265
Score = 84.7 bits (208), Expect = 4e-15, Method: Composition-based stats.
Identities = 69/252 (27%), Positives = 110/252 (43%), Gaps = 18/252 (7%)
Query: 3 VLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVSKS 62
VLVTRP E+ ++L + G A+ P I + +L + + VS +
Sbjct: 17 VLVTRPAEQAEKLSQAIELEGGQAVRFPTVEIGDSEVPAVVEEIIGRLDDFHWAVFVSAN 76
Query: 63 AVD------FAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLL 116
AV FA + + A +L VG+ TAQ P P+ NSE LL
Sbjct: 77 AVQRGVPWVFARREMPA-------NLKIAVVGRATAQALGNFGLYPRLCPSYGYNSEALL 129
Query: 117 QLNAMQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRR---EPIVYNNAEQTSI 173
++ +QD+ + V++ R +GGREL A+ +RGA VE E YRR P V N Q
Sbjct: 130 AMDELQDMKGQQVVLFRASGGRELLAKTLTKRGAKVEYAEVYRRCLPSPSVAANLRQVL- 188
Query: 174 CKRAGIQTIVVTSAEILTQLVDFVPQNEHNWLKSCQLITVSERIAHLAEALGWQNVVISP 233
+ ++ TS +L L + L+ L+ + R A LG+ + ++
Sbjct: 189 -VNVPVDVVITTSKAVLENLCHLAGEPLLEKLRRTPLVVIGSRQVQQARELGFTQIWVAQ 247
Query: 234 RADNQTLLQTLL 245
+ L+QT++
Sbjct: 248 EPSDAALVQTII 259
>gi|153872668|ref|ZP_02001493.1| Uroporphyrinogen III synthase HEM4 [Beggiatoa sp. PS]
gi|152070865|gb|EDN68506.1| Uroporphyrinogen III synthase HEM4 [Beggiatoa sp. PS]
Length = 271
Score = 84.7 bits (208), Expect = 4e-15, Method: Composition-based stats.
Identities = 80/270 (29%), Positives = 119/270 (44%), Gaps = 32/270 (11%)
Query: 1 MAVLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVS 60
+ +LVTRP + + L ++ G +I LP+ I + L + L D +S
Sbjct: 6 IKILVTRPAHQAEHLCQLIEAEGGQSIRLPVIEIIDIEDKTALFDCRMHLDELDIAIFIS 65
Query: 61 KSAVDFAFKTL------------------TATGFVWRHD--LHYFTVGQGTAQYFTATTE 100
+AVD + TL +T + R + L VG+ T A
Sbjct: 66 ANAVDKSLPTLLTPNHSENEKDSLTPVSTNSTTYFQREEQTLQIIAVGKRTTSTLKAWG- 124
Query: 101 MPVHYPTAQENSEGLLQLNAMQD--LSDKTVLILRGNGGRELFAEQAQQRGANVEIVECY 158
+ P + NSE +L++ MQ + K ++I RG GGREL AE QQRGA V + Y
Sbjct: 125 LTALCPDSPFNSEAVLKMPQMQTEVVQGKKIVIFRGEGGRELLAETLQQRGAIVNYINVY 184
Query: 159 RR-EPIVYNNAEQTSICKRAGIQTIVVTSAEILTQLVDFVPQNEHNWLKSCQLITVSERI 217
RR +P V S + I VTS E L L + + + WL + +SERI
Sbjct: 185 RRIQPSVPKWIADIS------VDVITVTSIEGLQNLFAML-EKQVAWLCHTPFVVMSERI 237
Query: 218 AHLAEALGWQN-VVISPRADNQTLLQTLLQ 246
A+ LG Q + ++P A + LL +LQ
Sbjct: 238 RTEAQKLGVQAPIFVAPTASDDGLLTAILQ 267
>gi|121528531|ref|ZP_01661145.1| putative bifunctional: uroporphyrin-III C-methyltransferase and
uroporphyrinogen-III synthase transmembrane protein
[Ralstonia pickettii 12J]
gi|121305299|gb|EAX46263.1| putative bifunctional: uroporphyrin-III C-methyltransferase and
uroporphyrinogen-III synthase transmembrane protein
[Ralstonia pickettii 12J]
Length = 702
Score = 84.7 bits (208), Expect = 5e-15, Method: Composition-based stats.
Identities = 75/258 (29%), Positives = 115/258 (44%), Gaps = 19/258 (7%)
Query: 3 VLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVSKS 62
V+VTRP + LV L + G+ PL I L++L V VS +
Sbjct: 29 VVVTRPRAQAPMLVAALERHGLRTHQFPLLDIAPTPNLDDLRAALGDPSRYALVVFVSPN 88
Query: 63 AVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMP---------VHYPTAQENSE 113
AV AF + GF W ++ VG +AQ P H A+++SE
Sbjct: 89 AVQQAFSAM-PEGFRWPQEVPVAVVGPASAQALATHGVAPPAHRVIKPDTHADDARQDSE 147
Query: 114 GLLQLNAMQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSI 173
L + LS + VLI+RGNGGRE A+Q ++ GA+V E YRR V + A ++
Sbjct: 148 ALYARLDVPSLSGREVLIVRGNGGREWLADQLREAGASVRTAEAYRRSVPVPDAAAWLAL 207
Query: 174 CKRAGIQT---IVVTSAEILTQLVDFVPQN----EHNWLKSCQLITVSERIAHLAEALGW 226
RA + + +TS+E + L + N + + L RI AE+LG+
Sbjct: 208 --RAVLSSRHAWTLTSSEAVRNLDELARANLSPADLDTLHGAPCFASHARIVEQAESLGF 265
Query: 227 QNVVISPRADNQTLLQTL 244
++V ++ D++ L L
Sbjct: 266 RDVTLTGAGDDRLLASVL 283
>gi|118038275|ref|ZP_01509679.1| protein of unknown function DUF513, hemX [Burkholderia phytofirmans
PsJN]
gi|117990938|gb|EAV05232.1| protein of unknown function DUF513, hemX [Burkholderia phytofirmans
PsJN]
Length = 672
Score = 84.3 bits (207), Expect = 5e-15, Method: Composition-based stats.
Identities = 84/259 (32%), Positives = 122/259 (47%), Gaps = 28/259 (10%)
Query: 3 VLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVSKS 62
V++TRP + +L+ LA AG+ + PL I + L A L+ V VS +
Sbjct: 20 VVITRPAGQSNELIARLAAAGIATLDFPLIDIAPVIDDAPLRAALASLERYALVVFVSPN 79
Query: 63 AVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFT----ATTEMPVHYP-------TAQEN 111
AVD AF + +W H L VG G+ Q A V P TA+ +
Sbjct: 80 AVDHAF---AQSDSIWPHALPIGVVGPGSVQALARHGVAAPAYNVISPPSGSDEDTARFD 136
Query: 112 SEGLLQ-LNAM---QDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRR---EPIV 164
SEGL ++A L K VLI+RG+GGRE AE+ ++ GA V+ V YRR EP +
Sbjct: 137 SEGLFAAIDAALGATSLEGKRVLIVRGDGGREWLAERLREAGAEVDTVAAYRRLVPEPSI 196
Query: 165 YNNAEQTSICKRAGI-QTIVVTSAEILTQLV----DFVPQNEHNWLKSCQLITVSERIAH 219
A + AG+ ++TS+E + L D + +E LK L+T RIA
Sbjct: 197 GAWARVHELL--AGVPHAWLLTSSEGVRNLNELAHDHLTADEIAQLKRAALVTPHPRIAQ 254
Query: 220 LAEALGWQNVVISPRADNQ 238
A ALG+ ++ +S D +
Sbjct: 255 TARALGFDSMTVSGAGDER 273
>gi|114771936|ref|ZP_01449325.1| uroporphyrinogen-III synthase HemD (N terminal)/Uroporphyrin-III
C-methyltransferase (C terminal) [alpha proteobacterium
HTCC2255]
Length = 249
Score = 84.3 bits (207), Expect = 5e-15, Method: Composition-based stats.
Identities = 78/250 (31%), Positives = 115/250 (46%), Gaps = 13/250 (5%)
Query: 4 LVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVSKSA 63
LV RP+ + +AG+ +I L L I ++ E + + D V SK A
Sbjct: 3 LVLRPEHKIDSSQHAFEQAGIPSIGLALQTILPRDDIAEQVH-LVNFHHVDNVIFTSKMA 61
Query: 64 VDFAFK---TLTATGFVWRHDLHYF-TVGQGTAQYFTATTEMPVHYPTA-QENSEGLLQL 118
FA L++ +V+ F T+ Q T QY + P A Q+ SEG+L L
Sbjct: 62 AQFALPFMPDLSSHTYVYAVGKSTFQTLAQWTHQYPFWCNNHQLMMPLAHQQTSEGILSL 121
Query: 119 NAMQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRAG 178
++ D++++ ++I++G GGRE + +RGA V EC E I NN T +
Sbjct: 122 PSLSDVTEQRIVIVKGLGGRETLRDTLSERGAVVS--ECTVYERITLNNPVSTQAWQVTD 179
Query: 179 IQTIVVTSAEILTQLVDFVPQNEHNWLKSCQLITVSERIAHLAEALGW--QNVVISPRAD 236
I I TS E L D P H+WL + + VS RIA A LG Q + IS AD
Sbjct: 180 ITGITATSNEQLQLAFDIYP---HSWLTELKWVVVSPRIAQYALKLGIPNQQISISQSAD 236
Query: 237 NQTLLQTLLQ 246
+ L+ + Q
Sbjct: 237 DAALIAHINQ 246
>gi|54295574|ref|YP_127989.1| Uroporphyrinogen-III synthetase [Legionella pneumophila str. Lens]
gi|53755406|emb|CAH16902.1| Uroporphyrinogen-III synthetase [Legionella pneumophila str. Lens]
Length = 250
Score = 84.3 bits (207), Expect = 6e-15, Method: Composition-based stats.
Identities = 60/234 (25%), Positives = 115/234 (49%), Gaps = 7/234 (2%)
Query: 1 MAVLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVS 60
+ +L TRP E+ + L + ++G + I P I + +E N + NK L + + VS
Sbjct: 8 LRILNTRPREQAEVLNKKIIESGGIPIDCPTMEIVA-SETNWI-NKLPDLTSVNQAIFVS 65
Query: 61 KSAVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQE--NSEGLLQL 118
+AV + L + W + + +G+GT++ E + E +SE LL L
Sbjct: 66 GNAVRYFMMELASKRINWPNSIRVAAIGKGTSRVLN---EFNIQVRDVPELPDSEHLLTL 122
Query: 119 NAMQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRAG 178
N++Q + ++T+L+++G GGR+L E +GA + I+ Y+R + S+ +
Sbjct: 123 NSLQQIRNQTILLVKGEGGRQLIEEYLMLKGAKLCILSVYKRVMPAIDQEFLNSLWRDDL 182
Query: 179 IQTIVVTSAEILTQLVDFVPQNEHNWLKSCQLITVSERIAHLAEALGWQNVVIS 232
I++TS + + L WL++ + +S+R+A +A G + ++IS
Sbjct: 183 ADIILLTSEQSIHNLFKMFSIEGQMWLQNKPCLVISDRLAKVASLFGIKKILIS 236
>gi|120553423|ref|YP_957774.1| Uroporphyrinogen III synthase HEM4 [Marinobacter aquaeolei VT8]
gi|120323272|gb|ABM17587.1| Uroporphyrinogen III synthase HEM4 [Marinobacter aquaeolei VT8]
Length = 270
Score = 84.3 bits (207), Expect = 6e-15, Method: Composition-based stats.
Identities = 69/249 (27%), Positives = 112/249 (44%), Gaps = 10/249 (4%)
Query: 3 VLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVSKS 62
VL+ RP+ +L + KAG A +P+ E E E +L N ++ AVS
Sbjct: 19 VLICRPEPEASRLAEAFRKAGADARVMPMMAREPLPETPEQRGILQQLDNFSHIIAVSPY 78
Query: 63 AVDFAFKTLTATGFVWRH---DLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLN 119
A A + + W L ++ VG GTA F P P SE LL L
Sbjct: 79 A---ARRLMEEIDHWWPQLPAGLQWYGVGAGTAAVFREHGLKP-RMPAEGWTSEALLALP 134
Query: 120 AMQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRAGI 179
++Q + + VL+ RG GREL E QRGA + + YRR Y+ + ++
Sbjct: 135 SLQRVDGEKVLLARGEHGRELIRETLAQRGARITTLPLYRRVLPYYSAKQVKALVADFHP 194
Query: 180 QTIVVTSAEILTQLVDFVPQNEHNWLKSCQLITV-SERIAHLAEALGWQNVVISPRADNQ 238
+ ++ S E L LV+ + + + +I V +ER+A A ALG++ ++ ++
Sbjct: 195 EVVIALSGETLNNLVEL--GHRYQLALTPDIIVVPAERVAEQARALGFRKPLVPGSLNDD 252
Query: 239 TLLQTLLQC 247
L+ ++ C
Sbjct: 253 DLVISVASC 261
>gi|148358524|ref|YP_001249731.1| uroporphyrinogen III methylase [Legionella pneumophila str. Corby]
gi|148280297|gb|ABQ54385.1| uroporphyrinogen III methylase [Legionella pneumophila str. Corby]
Length = 250
Score = 83.2 bits (204), Expect = 1e-14, Method: Composition-based stats.
Identities = 59/234 (25%), Positives = 110/234 (47%), Gaps = 7/234 (2%)
Query: 1 MAVLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVS 60
+ +L TRP E+ Q L + ++G + I P I A N N L + VS
Sbjct: 8 LRILNTRPREQAQVLNKKIIESGGIPIDCPTMEIM--ASENNWINNLPDLTLVNQAIFVS 65
Query: 61 KSAVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQE--NSEGLLQL 118
+AV + L + W + + +G+GT++ E + E +SE LL L
Sbjct: 66 ANAVRYFMMELASKSINWPNSIRVAAIGKGTSRVLN---EFNIQVSDIPELPDSEHLLTL 122
Query: 119 NAMQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRAG 178
N++Q + ++T+L+++G GGR+L E +GA + ++ Y+R + S+ +
Sbjct: 123 NSLQQIRNQTILLVKGEGGRQLIEEYLMLKGAKLCLLSVYKRVMPTIDKEFLNSLWRDDL 182
Query: 179 IQTIVVTSAEILTQLVDFVPQNEHNWLKSCQLITVSERIAHLAEALGWQNVVIS 232
I++TS + + L WL++ + +S+R+A +A G + ++IS
Sbjct: 183 ADIILLTSEQSIHNLFKMFSIEGQMWLQNKPCLVISDRLAKVASLFGIKKILIS 236
>gi|74318585|ref|YP_316325.1| uroporphyrinogen-III synthase [Thiobacillus denitrificans ATCC
25259]
gi|74058080|gb|AAZ98520.1| uroporphyrinogen-III synthase [Thiobacillus denitrificans ATCC
25259]
Length = 252
Score = 83.2 bits (204), Expect = 1e-14, Method: Composition-based stats.
Identities = 73/237 (30%), Positives = 102/237 (43%), Gaps = 12/237 (5%)
Query: 3 VLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVSKS 62
+LVTR + L + AG A P E+ ++ L A++ D+V VS +
Sbjct: 10 ILVTRAPRQAAALSAAIRAAGGSAFEFPALAFEA-VPVDRLQASLAQVVAADFVIFVSPN 68
Query: 63 AVDF---AFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLN 119
A +F A +L A V VG GTA+ A V P Q+ SE LL L
Sbjct: 69 AAEFGMAAIGSLAAGRSV-------LAVGPGTARALAAQGLDAVITPDGQD-SEALLALP 120
Query: 120 AMQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRAGI 179
+ D+ K V+I+RG GGR L + RGA V +ECYRR + A + + GI
Sbjct: 121 QLLDVDGKRVVIVRGIGGRALLGDTLAARGAEVHYMECYRRLAPTADAAPLIARWQAGGI 180
Query: 180 QTIVVTSAEILTQLVDFVPQNEHNWLKSCQLITVSERIAHLAEALGWQNVVISPRAD 236
+ V SAE L L + + L L E+IA A + G +P D
Sbjct: 181 DAVTVASAETLHNLAALLGEAGAPLLAHTPLFAPYEKIAAAARSFGVAQATATPGGD 237
>gi|99910313|ref|ZP_01317340.1| hypothetical protein Bpse1_03003260 [Burkholderia pseudomallei
1655]
Length = 659
Score = 82.8 bits (203), Expect = 2e-14, Method: Composition-based stats.
Identities = 80/260 (30%), Positives = 120/260 (46%), Gaps = 27/260 (10%)
Query: 4 LVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVSKSA 63
++TRPD + L LA AG+ + PL I A+ L FA+L V VS +A
Sbjct: 11 VLTRPDGQSAALAAQLAAAGIDVLDFPLIDIAPLADDAPLAEAFARLDAYALVVFVSPNA 70
Query: 64 VDFAFKTLTATGFVWRHDLHYFTVGQGT----AQYFTATTEMPVHYPTAQEN-------S 112
VD A L G +W H L VG G+ A++ A V P+A ++ S
Sbjct: 71 VDHALARL---GAIWPHPLPIGVVGPGSVAALARHGIAAPAHRVIAPSAPDDGGEPHYDS 127
Query: 113 EGLLQ-----LNAMQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRR---EPIV 164
E L + L+ K VLI+RG+GGRE FAE+ ++ GA VE+V YRR EP +
Sbjct: 128 ESLFAEIARAFDGEAKLAGKRVLIVRGDGGREWFAERLREAGAEVELVAAYRRVSPEPSI 187
Query: 165 YNNAEQTSICKRAGIQTIVVTSAEILTQLVDF----VPQNEHNWLKSCQLITVSERIAHL 220
E+ +VTS+E + L + + + E + LK + + RI
Sbjct: 188 -GAWERVHALLSGAPHAWLVTSSEGVRNLQELAHEHLNETEIDALKHARFVAPHSRIVET 246
Query: 221 AEALGWQNVVISPRADNQTL 240
A ALG+ + ++ D + +
Sbjct: 247 ARALGFDRITLTGAGDERIV 266
>gi|53718658|ref|YP_107644.1| uroporphyrinogen-III synthetase [Burkholderia pseudomallei K96243]
gi|52209072|emb|CAH35012.1| putative bifunctional protein (uroporphyrin-III C-methyltransferase
and uroporphyrinogen-III synthase transmembrane protein)
[Burkholderia pseudomallei K96243]
Length = 660
Score = 82.4 bits (202), Expect = 2e-14, Method: Composition-based stats.
Identities = 80/260 (30%), Positives = 119/260 (45%), Gaps = 27/260 (10%)
Query: 4 LVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVSKSA 63
++TRPD + L LA AG+ + PL I A+ L FA+L V VS +A
Sbjct: 12 VLTRPDGQSAALAAQLAAAGIDVLDFPLIDIAPLADDAPLAEAFARLDAYALVVFVSPNA 71
Query: 64 VDFAFKTLTATGFVWRHDLHYFTVGQGT----AQYFTATTEMPVHYPTAQEN-------S 112
VD A L G +W H L VG G+ A++ A V P+A ++ S
Sbjct: 72 VDHALARL---GAIWPHPLPIGVVGPGSVAALARHGIAAPAHRVIAPSAPDDGGEPHYDS 128
Query: 113 EGLLQ-----LNAMQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRR---EPIV 164
E L N L+ K VLI+RG+GGRE AE+ ++ GA VE+V YRR EP +
Sbjct: 129 ESLFAEIARAFNGEAKLAGKRVLIVRGDGGREWLAERLREAGAEVELVAAYRRVSPEPSI 188
Query: 165 YNNAEQTSICKRAGIQTIVVTSAEILTQLVDF----VPQNEHNWLKSCQLITVSERIAHL 220
E+ +VTS+E + L + + + E + LK + + RI
Sbjct: 189 -GAWERVHALLSGAPHAWLVTSSEGVRNLQELAHEHLNETEIDALKHARFVAPHSRIVET 247
Query: 221 AEALGWQNVVISPRADNQTL 240
A ALG+ + ++ D + +
Sbjct: 248 ARALGFDRITLTGAGDERIV 267
>gi|100236282|ref|ZP_01336899.1| hypothetical protein Bpse4_03000447 [Burkholderia pseudomallei
406e]
Length = 659
Score = 82.4 bits (202), Expect = 2e-14, Method: Composition-based stats.
Identities = 80/260 (30%), Positives = 119/260 (45%), Gaps = 27/260 (10%)
Query: 4 LVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVSKSA 63
++TRPD + L LA AG+ + PL I A+ L FA+L V VS +A
Sbjct: 11 VLTRPDGQSAALAAQLAAAGIDVLDFPLIDIAPLADDAPLAEAFARLDAYALVVFVSPNA 70
Query: 64 VDFAFKTLTATGFVWRHDLHYFTVGQGT----AQYFTATTEMPVHYPTAQEN-------S 112
VD A L G +W H L VG G+ A++ A V P+A ++ S
Sbjct: 71 VDHALARL---GAIWPHPLPIGVVGPGSVAALARHGIAAPAHRVIAPSAPDDGGEPHYDS 127
Query: 113 EGLLQ-----LNAMQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRR---EPIV 164
E L N L+ K VLI+RG+GGRE AE+ ++ GA VE+V YRR EP +
Sbjct: 128 ESLFAEIARAFNGEAKLAGKRVLIVRGDGGREWLAERLREAGAEVELVAAYRRVSPEPSI 187
Query: 165 YNNAEQTSICKRAGIQTIVVTSAEILTQLVDF----VPQNEHNWLKSCQLITVSERIAHL 220
E+ +VTS+E + L + + + E + LK + + RI
Sbjct: 188 -GAWERVHALLSGAPHAWLVTSSEGVRNLQELAHEHLNETEIDALKHARFVAPHSRIVET 246
Query: 221 AEALGWQNVVISPRADNQTL 240
A ALG+ + ++ D + +
Sbjct: 247 ARALGFDRITLTGAGDERIV 266
>gi|82536537|ref|ZP_00895542.1| hypothetical protein Bpse110_02002199 [Burkholderia pseudomallei
1106b]
gi|126453804|ref|YP_001065358.1| putative uroporphyrinogen-III synthase HemD/uroporphyrinogen III
methylase HemX [Burkholderia pseudomallei 1106a]
gi|126227446|gb|ABN90986.1| putative uroporphyrinogen-III synthase HemD/uroporphyrinogen III
methylase HemX [Burkholderia pseudomallei 1106a]
Length = 659
Score = 82.4 bits (202), Expect = 2e-14, Method: Composition-based stats.
Identities = 80/260 (30%), Positives = 119/260 (45%), Gaps = 27/260 (10%)
Query: 4 LVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVSKSA 63
++TRPD + L LA AG+ + PL I A+ L FA+L V VS +A
Sbjct: 11 VLTRPDGQSAALAAQLAAAGIDVLDFPLIDIAPLADDAPLAEAFARLDAYALVVFVSPNA 70
Query: 64 VDFAFKTLTATGFVWRHDLHYFTVGQGT----AQYFTATTEMPVHYPTAQEN-------S 112
VD A L G +W H L VG G+ A++ A V P+A ++ S
Sbjct: 71 VDHALARL---GAIWPHPLPIGVVGPGSVAALARHGIAAPAHRVIAPSAPDDGGEPHYDS 127
Query: 113 EGLLQ-----LNAMQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRR---EPIV 164
E L N L+ K VLI+RG+GGRE AE+ ++ GA VE+V YRR EP +
Sbjct: 128 ESLFAEIARAFNGEAKLAGKRVLIVRGDGGREWLAERLREAGAEVELVAAYRRVSPEPSI 187
Query: 165 YNNAEQTSICKRAGIQTIVVTSAEILTQLVDF----VPQNEHNWLKSCQLITVSERIAHL 220
E+ +VTS+E + L + + + E + LK + + RI
Sbjct: 188 -GAWERVHALLSGAPHAWLVTSSEGVRNLQELAHEHLNETEIDALKHARFVAPHSRIVET 246
Query: 221 AEALGWQNVVISPRADNQTL 240
A ALG+ + ++ D + +
Sbjct: 247 ARALGFDRITLTGAGDERIV 266
>gi|149376991|ref|ZP_01894745.1| Uroporphyrinogen-III synthase [Marinobacter algicola DG893]
gi|149358768|gb|EDM47238.1| Uroporphyrinogen-III synthase [Marinobacter algicola DG893]
Length = 270
Score = 82.0 bits (201), Expect = 3e-14, Method: Composition-based stats.
Identities = 70/235 (29%), Positives = 98/235 (41%), Gaps = 14/235 (5%)
Query: 3 VLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVSKS 62
+LV RP +L AG A +PL E E L +V AVS
Sbjct: 16 ILVCRPQPEADRLASRFCDAGADARVMPLIAREPLPEDPATRTLILNLDEFAHVIAVSPY 75
Query: 63 AVDFAFKTL------TATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLL 116
A L T TG +H++ VG GTA + + P SE LL
Sbjct: 76 AAALLLDWLDEWWPQTPTG------IHWYGVGAGTATVLS-NYGLETRQPETGHTSEDLL 128
Query: 117 QLNAMQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKR 176
QL + L+ + VL++RG GREL + ++RGA V ++ YRR Y+ A ++
Sbjct: 129 QLPELATLNHEKVLVVRGQEGRELIPQTLERRGARVTVLPLYRRFCPDYDKATLNAMLND 188
Query: 177 AGIQTIVVTSAEILTQLVDFVPQNEHNWLKSCQLITVSERIAHLAEALGWQNVVI 231
+ IV S E L L+ HN L++ L+ ERIA A G + I
Sbjct: 189 FSPEAIVTLSGETLNNLIALSDNTGHN-LENTLLVVPVERIAEQARLAGLRRTCI 242
>gi|153888974|ref|ZP_02010109.1| protein of unknown function DUF513, hemX [Ralstonia pickettii 12D]
gi|151574557|gb|EDN38978.1| protein of unknown function DUF513, hemX [Ralstonia pickettii 12D]
Length = 787
Score = 81.6 bits (200), Expect = 4e-14, Method: Composition-based stats.
Identities = 73/255 (28%), Positives = 112/255 (43%), Gaps = 19/255 (7%)
Query: 6 TRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVSKSAVD 65
TRP + LV L + G+ PL I L++L V VS +AV
Sbjct: 115 TRPRAQAPMLVAALERHGLRTHQFPLLDIAPTPNLDDLRAALGDPSRYALVVFVSPNAVQ 174
Query: 66 FAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMP---------VHYPTAQENSEGLL 116
AF + GF W ++ VG +AQ P H A+++SE L
Sbjct: 175 QAFAAM-PEGFRWPQEVPVAVVGPASAQALATHGVAPPAYRVIKPDTHAGDARQDSEALY 233
Query: 117 QLNAMQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKR 176
+ LS + VLI+RGNGGRE A+Q ++ GA+V E YRR V + A ++ R
Sbjct: 234 ARLDVPSLSGREVLIVRGNGGREWLADQLREAGASVRTAEAYRRSVPVPDAAAWLAL--R 291
Query: 177 AGIQT---IVVTSAEILTQLVDFVPQN----EHNWLKSCQLITVSERIAHLAEALGWQNV 229
A + + +TS+E + L + N + + L RI AE+LG+++V
Sbjct: 292 AVLSSRHAWTLTSSEAVRNLDELARANLSPADLDTLHGAPCFASHARIVEQAESLGFRDV 351
Query: 230 VISPRADNQTLLQTL 244
++ D++ L L
Sbjct: 352 TLTGAGDDRLLASVL 366
>gi|77461707|ref|YP_351214.1| Uroporphyrinogen III synthase HEM4 [Pseudomonas fluorescens PfO-1]
gi|77385710|gb|ABA77223.1| Uroporphyrinogen III synthase HEM4 [Pseudomonas fluorescens PfO-1]
Length = 255
Score = 81.3 bits (199), Expect = 5e-14, Method: Composition-based stats.
Identities = 73/233 (31%), Positives = 103/233 (44%), Gaps = 10/233 (4%)
Query: 3 VLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVSKS 62
+L+TRP E L +LA+ G + LPL I + + +L V VSK
Sbjct: 6 LLLTRPAEDCSALAAVLAEQGFFSSCLPLLEIAPLPVSDTMRRTIMQLPRYSAVIVVSKP 65
Query: 63 AVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNAMQ 122
A A L A + +F+VG TA + V +P A ++SE LLQL +
Sbjct: 66 AARIAVDLLDALRLA-TPTMPWFSVGAATAAILR-DRGLDVSFPDAGDDSEALLQLPRLL 123
Query: 123 D---LSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRAGI 179
+ + VLILRG GGREL E+ + GA+VE +E YRR+ Y E +
Sbjct: 124 EAVAMPGSQVLILRGEGGRELLGERLRTLGASVEYLELYRRDLPDYPPQELPRRIAAERL 183
Query: 180 QTIVVTSAEILTQLVDFVPQNEHNW--LKSCQLITVSERIAHLAEALGWQNVV 230
+VV+S + L +W L L S R+A A A G + VV
Sbjct: 184 NGLVVSSGQGFEHLRQLAGD---SWPALAQLPLFVPSPRVAEQASAAGARTVV 233
>gi|83720469|ref|YP_441429.1| uroporphyrinogen-III synthase HemD/uroporphyrinogen III methylase
HemX, putative [Burkholderia thailandensis E264]
gi|83654294|gb|ABC38357.1| uroporphyrinogen-III synthase HemD/uroporphyrinogen III methylase
HemX, putative [Burkholderia thailandensis E264]
Length = 659
Score = 80.9 bits (198), Expect = 7e-14, Method: Composition-based stats.
Identities = 79/260 (30%), Positives = 118/260 (45%), Gaps = 27/260 (10%)
Query: 4 LVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVSKSA 63
++TRPD + L LA AG+ + PL I A+ L FA+L V VS +A
Sbjct: 11 VLTRPDGQSAALAAQLAAAGIDTLDFPLIDIAPLADDAPLAEAFARLDAYALVVFVSPNA 70
Query: 64 VDFAFKTLTATGFVWRHDLHYFTVGQGT----AQYFTATTEMPVHYPTAQEN-------S 112
+D A L G +W H L VG G+ A++ A V P A ++ S
Sbjct: 71 IDRALARL---GAIWPHPLPIGVVGPGSVAALARHGVAVPAHRVIAPRAPDDGGEPHYDS 127
Query: 113 EGLLQ-----LNAMQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRR---EPIV 164
E L + L+ K VLI+RG+GGRE AE+ ++ GA VE+V YRR EP +
Sbjct: 128 ESLFAEIARAFDGEAKLAGKRVLIVRGDGGREWLAERLREAGAEVELVAAYRRVSPEPSI 187
Query: 165 YNNAEQTSICKRAGIQTIVVTSAEILTQLVDF----VPQNEHNWLKSCQLITVSERIAHL 220
E+ +VTS+E + L + + + E + L+ Q + RI
Sbjct: 188 -GTWERVHALLSGAPHAWLVTSSEGVRNLQELAHEHLNETEIDALRRAQFVAPHPRIVET 246
Query: 221 AEALGWQNVVISPRADNQTL 240
A ALG+ + +S D + +
Sbjct: 247 ARALGFDRITLSGAGDERIV 266
>gi|100123077|ref|ZP_01328783.1| hypothetical protein BpseS_03003148 [Burkholderia pseudomallei S13]
Length = 659
Score = 80.5 bits (197), Expect = 7e-14, Method: Composition-based stats.
Identities = 80/260 (30%), Positives = 119/260 (45%), Gaps = 27/260 (10%)
Query: 4 LVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVSKSA 63
++TRPD + L LA AG+ + PL I A+ L FA+L V VS +A
Sbjct: 11 VLTRPDGQSAALAAQLAAAGIDVLDFPLIDIAPLADDAPLAEAFARLDAYALVVFVSPNA 70
Query: 64 VDFAFKTLTATGFVWRHDLHYFTVGQGT----AQYFTATTEMPVHYPTAQEN-------S 112
VD A L G +W H L VG G+ A++ A V P+A ++ S
Sbjct: 71 VDHAPARL---GAIWPHPLPIGVVGPGSVAALARHGIAAPAHRVIAPSAPDDGGEPHYDS 127
Query: 113 EGLLQ-----LNAMQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRR---EPIV 164
E L N L+ K VLI+RG+GGRE AE+ ++ GA VE+V YRR EP +
Sbjct: 128 ESLFAEIARAFNGEAKLAGKRVLIVRGDGGREWLAERLREAGAEVELVAAYRRVSPEPSI 187
Query: 165 YNNAEQTSICKRAGIQTIVVTSAEILTQLVDF----VPQNEHNWLKSCQLITVSERIAHL 220
E+ +VTS+E + L + + + E + LK + + RI
Sbjct: 188 -GAWERVHALLSGAPHAWLVTSSEGVRNLQELAHEHLNETEIDALKHARFVAPHSRIVET 246
Query: 221 AEALGWQNVVISPRADNQTL 240
A ALG+ + ++ D + +
Sbjct: 247 ARALGFDRITLTGAGDERIV 266
>gi|100063476|ref|ZP_01325007.1| hypothetical protein BpseP_03001237 [Burkholderia pseudomallei
Pasteur]
Length = 659
Score = 80.5 bits (197), Expect = 8e-14, Method: Composition-based stats.
Identities = 79/260 (30%), Positives = 119/260 (45%), Gaps = 27/260 (10%)
Query: 4 LVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVSKSA 63
++TRPD + L LA AG+ + PL I A+ L FA+L V VS +A
Sbjct: 11 VLTRPDGQSAALAAQLAAAGIDVLDFPLIDIAPLADDAPLAEAFARLDAYALVVFVSPNA 70
Query: 64 VDFAFKTLTATGFVWRHDLHYFTVGQGT----AQYFTATTEMPVHYPTAQEN-------S 112
VD A L G +W H L VG G+ A++ A V P+A ++ S
Sbjct: 71 VDHALARL---GAIWPHPLPIGVVGPGSVAALARHGIAAPAHRVIAPSAPDDGGEPHYDS 127
Query: 113 EGLLQ-----LNAMQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRR---EPIV 164
E L + L+ K VLI+RG+GGRE AE+ ++ GA VE+V YRR EP +
Sbjct: 128 ESLFAEIARAFDGEAKLAGKRVLIVRGDGGREWLAERLREAGAEVELVAAYRRVSPEPSI 187
Query: 165 YNNAEQTSICKRAGIQTIVVTSAEILTQLVDF----VPQNEHNWLKSCQLITVSERIAHL 220
E+ +VTS+E + L + + + E + LK + + RI
Sbjct: 188 -GAWERVHALLSGAPHAWLVTSSEGVRNLQELAHEHLNETEIDALKHARFVAPHSRIVET 246
Query: 221 AEALGWQNVVISPRADNQTL 240
A ALG+ + ++ D + +
Sbjct: 247 ARALGFDRITLTGAGDERIV 266
>gi|76811096|ref|YP_332642.1| uroporphyrinogen-III synthetase [Burkholderia pseudomallei 1710b]
gi|90293966|ref|ZP_01213563.1| hypothetical protein Bpse17_02001267 [Burkholderia pseudomallei
1710a]
gi|76580549|gb|ABA50024.1| uroporphyrin-III C-methyltransferase [Burkholderia pseudomallei
1710b]
Length = 659
Score = 80.5 bits (197), Expect = 8e-14, Method: Composition-based stats.
Identities = 79/260 (30%), Positives = 119/260 (45%), Gaps = 27/260 (10%)
Query: 4 LVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVSKSA 63
++TRPD + L LA AG+ + PL I A+ L FA+L V VS +A
Sbjct: 11 VLTRPDGQSAALAAQLAAAGIDVLDFPLIDIAPLADDAPLAEAFARLDAYALVVFVSPNA 70
Query: 64 VDFAFKTLTATGFVWRHDLHYFTVGQGT----AQYFTATTEMPVHYPTAQEN-------S 112
VD A L G +W H L VG G+ A++ A V P+A ++ S
Sbjct: 71 VDHALARL---GAIWPHPLPIGVVGPGSVAALARHGIAAPAHRVIAPSAPDDGGEPHYDS 127
Query: 113 EGLLQ-----LNAMQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRR---EPIV 164
E L + L+ K VLI+RG+GGRE AE+ ++ GA VE+V YRR EP +
Sbjct: 128 ESLFAEIARAFDGEAKLAGKRVLIVRGDGGREWLAERLREAGAEVELVAAYRRVSPEPSI 187
Query: 165 YNNAEQTSICKRAGIQTIVVTSAEILTQLVDF----VPQNEHNWLKSCQLITVSERIAHL 220
E+ +VTS+E + L + + + E + LK + + RI
Sbjct: 188 -GAWERVHALLSGAPHAWLVTSSEGVRNLQELAHEHLNETEIDALKHARFVAPHSRIVET 246
Query: 221 AEALGWQNVVISPRADNQTL 240
A ALG+ + ++ D + +
Sbjct: 247 ARALGFDRITLTGAGDERIV 266
>gi|53725179|ref|YP_102500.1| uroporphyrinogen-III synthetase [Burkholderia mallei ATCC 23344]
gi|67640111|ref|ZP_00438930.1| COG2959: Uncharacterized enzyme of heme biosynthesis [Burkholderia
mallei GB8 horse 4]
gi|83619064|ref|ZP_00929508.1| COG2959: Uncharacterized enzyme of heme biosynthesis [Burkholderia
mallei FMH]
gi|83623956|ref|ZP_00934214.1| COG2959: Uncharacterized enzyme of heme biosynthesis [Burkholderia
mallei JHU]
gi|100265071|ref|ZP_01339631.1| hypothetical protein Bmal2_03002674 [Burkholderia mallei
2002721280]
gi|100915664|ref|ZP_01344152.1| hypothetical protein Bmal10_03002968 [Burkholderia mallei 10399]
gi|121600915|ref|YP_993592.1| putative uroporphyrinogen-III synthase HemD/uroporphyrinogen III
methylase HemX [Burkholderia mallei SAVP1]
gi|124385453|ref|YP_001028945.1| putative uroporphyrinogen-III synthase HemD/uroporphyrinogen III
methylase HemX [Burkholderia mallei NCTC 10229]
gi|126440099|ref|YP_001058122.1| uroporphyrinogen-III synthetase [Burkholderia pseudomallei 668]
gi|126449812|ref|YP_001081140.1| putative uroporphyrinogen-III synthase HemD/uroporphyrinogen III
methylase HemX [Burkholderia mallei NCTC 10247]
gi|134281236|ref|ZP_01767945.1| putative uroporphyrinogen-III synthase HemD/putative
uroporphyrinogen III methylase HemX [Burkholderia
pseudomallei 305]
gi|52428602|gb|AAU49195.1| uroporphyrinogen-III synthase HemD/uroporphyrinogen III methylase
HemX, putative [Burkholderia mallei ATCC 23344]
gi|121229725|gb|ABM52243.1| putative uroporphyrinogen-III synthase HemD/uroporphyrinogen III
methylase HemX [Burkholderia mallei SAVP1]
gi|124293473|gb|ABN02742.1| putative uroporphyrinogen-III synthase HemD/uroporphyrinogen III
methylase HemX [Burkholderia mallei NCTC 10229]
gi|126219592|gb|ABN83098.1| uroporphyrinogen-III synthetase [Burkholderia pseudomallei 668]
gi|126242682|gb|ABO05775.1| putative uroporphyrinogen-III synthase HemD/uroporphyrinogen III
methylase HemX [Burkholderia mallei NCTC 10247]
gi|134247542|gb|EBA47627.1| putative uroporphyrinogen-III synthase HemD/putative
uroporphyrinogen III methylase HemX [Burkholderia
pseudomallei 305]
gi|147749001|gb|EDK56075.1| putative uroporphyrinogen-III synthase HemD/putative
uroporphyrinogen III methylase HemX [Burkholderia mallei
FMH]
gi|147753163|gb|EDK60228.1| putative uroporphyrinogen-III synthase HemD/putative
uroporphyrinogen III methylase HemX [Burkholderia mallei
JHU]
gi|148027005|gb|EDK85026.1| putative uroporphyrinogen-III synthase HemD/putative
uroporphyrinogen III methylase HemX [Burkholderia mallei
2002721280]
Length = 659
Score = 80.5 bits (197), Expect = 8e-14, Method: Composition-based stats.
Identities = 79/260 (30%), Positives = 119/260 (45%), Gaps = 27/260 (10%)
Query: 4 LVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVSKSA 63
++TRPD + L LA AG+ + PL I A+ L FA+L V VS +A
Sbjct: 11 VLTRPDGQSAALAAQLAAAGIDVLDFPLIDIAPLADDAPLAEAFARLDAYALVVFVSPNA 70
Query: 64 VDFAFKTLTATGFVWRHDLHYFTVGQGT----AQYFTATTEMPVHYPTAQEN-------S 112
VD A L G +W H L VG G+ A++ A V P+A ++ S
Sbjct: 71 VDHALARL---GAIWPHPLPIGVVGPGSVAALARHGIAAPAHRVIAPSAPDDGGEPHYDS 127
Query: 113 EGLLQ-----LNAMQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRR---EPIV 164
E L + L+ K VLI+RG+GGRE AE+ ++ GA VE+V YRR EP +
Sbjct: 128 ESLFAEIARAFDGEAKLAGKRVLIVRGDGGREWLAERLREAGAEVELVAAYRRVSPEPSI 187
Query: 165 YNNAEQTSICKRAGIQTIVVTSAEILTQLVDF----VPQNEHNWLKSCQLITVSERIAHL 220
E+ +VTS+E + L + + + E + LK + + RI
Sbjct: 188 -GAWERVHALLSGAPHAWLVTSSEGVRNLQELAHEHLNETEIDALKHARFVAPHSRIVET 246
Query: 221 AEALGWQNVVISPRADNQTL 240
A ALG+ + ++ D + +
Sbjct: 247 ARALGFDRITLTGAGDERIV 266
>gi|126666606|ref|ZP_01737584.1| Uroporphyrinogen-III synthase [Marinobacter sp. ELB17]
gi|126628994|gb|EAZ99613.1| Uroporphyrinogen-III synthase [Marinobacter sp. ELB17]
Length = 268
Score = 78.2 bits (191), Expect = 4e-13, Method: Composition-based stats.
Identities = 63/226 (27%), Positives = 98/226 (43%), Gaps = 2/226 (0%)
Query: 3 VLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVSKS 62
+L+ RP +L AG A LPL A E L ++ AVS
Sbjct: 18 ILICRPQPEADRLAIAFQAAGAQAECLPLIDRAPLALSAEHQAHIQNLDLFQHIVAVSPY 77
Query: 63 AVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNAMQ 122
A + + A +H++ VG GTA + + P SE LL L +Q
Sbjct: 78 AARQLLEQVDAWWPQLPVGIHWYGVGAGTAAELSRCG-ITARRPAQGWTSEALLALPPLQ 136
Query: 123 DLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRAGIQTI 182
+L+++ VL+ RG GR+L +QRGA + ++ YRR Y+ A+ +
Sbjct: 137 NLANQRVLLARGGDGRDLLRNTLRQRGAQITVLPLYRRFCPQYSAAQLAHALDGFNPDAV 196
Query: 183 VVTSAEILTQLVDFVPQNEHNWLKSCQLITVSERIAHLAEALGWQN 228
+ S E L LV +N+HN + ++ V ER+A A+ G+ N
Sbjct: 197 ITLSGETLKNLVALCAKNDHNLYRKLLIVPV-ERVAEQAQTAGFIN 241
>gi|146280920|ref|YP_001171073.1| uroporphyrinogen-III synthetase [Pseudomonas stutzeri A1501]
gi|145569125|gb|ABP78231.1| uroporphyrinogen-III synthetase [Pseudomonas stutzeri A1501]
Length = 256
Score = 78.2 bits (191), Expect = 4e-13, Method: Composition-based stats.
Identities = 74/233 (31%), Positives = 106/233 (45%), Gaps = 9/233 (3%)
Query: 3 VLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVSKS 62
+L+TRP E + L LA+AGV + LPL IE E E +L V VSK
Sbjct: 6 LLLTRPAEECEALAATLAEAGVHSSSLPLLAIEPLPESAEQRATILELDRYCAVVVVSKP 65
Query: 63 AVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNAM- 121
A + L +F+VG T A + V +P ++SE LL L +
Sbjct: 66 AARLGLELLDRYWPQPPFGQAWFSVGGATGAILEAYG-LDVSWPERGDDSEALLALPRLA 124
Query: 122 QDLS--DKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRAGI 179
Q L+ D VLI+RG GGRE AE + RG V+ +E YRR Y + + +
Sbjct: 125 QALARPDPKVLIMRGEGGREFLAETLRGRGVQVDFLELYRRSLPDYPPGTLVQVVRSERL 184
Query: 180 QTIVVTSAEILTQLVDFVPQNEHNWLKSCQ--LITVSERIAHLAEALGWQNVV 230
+VV+S + L L + W + C+ L S R+A +A LG + +V
Sbjct: 185 NGLVVSSGQGLLSLHELAAD---TWPELCELPLFVPSPRVAEMARQLGAKRIV 234
>gi|92115223|ref|YP_575151.1| Uroporphyrinogen III synthase HEM4 [Chromohalobacter salexigens DSM
3043]
gi|91798313|gb|ABE60452.1| Uroporphyrinogen III synthase HEM4 [Chromohalobacter salexigens DSM
3043]
Length = 251
Score = 77.8 bits (190), Expect = 5e-13, Method: Composition-based stats.
Identities = 68/246 (27%), Positives = 111/246 (45%), Gaps = 11/246 (4%)
Query: 3 VLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVSKS 62
++VTRP E G++LVD L+ AG A+H L ++ A D V S
Sbjct: 7 IVVTRPGEGGRRLVDALSTAGFEAVHPALMTLQPLAADEVERGAVLDFDLYDVVVVTSPF 66
Query: 63 AVDFAFKTLTATGFVWRHDLHYFTVGQGTAQ--YFTATTEMPVHYPTAQENSEGLLQLNA 120
A + + + ++ VG TA + T + V P SE LL + +
Sbjct: 67 AAECLDEWIDRYWPQLPQGPRFYAVGASTAATLHRTLGIKAKVPDPARGTTSEALLAMRS 126
Query: 121 MQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSI--CKRAG 178
+ L + LI+ G+GGR++ AE + RGA V + YRR VY ++ ++
Sbjct: 127 LTRLDGQRALIVGGSGGRQVMAEALEARGARVAKLALYRR---VYTAPDEVTVDWLASGA 183
Query: 179 IQTIVVTSAEILTQLVDFVPQNEHNWLKSCQLITVSERIAHLAEALGWQNVVISPRADNQ 238
++VTS E+L LV + Q N LI S+R+A LA+ +G+ + ++ A
Sbjct: 184 FTAMIVTSGELLEHLVSWCGQAALNK----PLIVSSQRLATLADTMGFASPHVASGATPD 239
Query: 239 TLLQTL 244
L+ +
Sbjct: 240 ALVTAV 245
>gi|28867369|ref|NP_789988.1| uroporphyrinogen-III synthetase [Pseudomonas syringae pv. tomato
str. DC3000]
gi|28850603|gb|AAO53683.1| uroporphyrinogen-III synthetase [Pseudomonas syringae pv. tomato
str. DC3000]
Length = 258
Score = 77.4 bits (189), Expect = 7e-13, Method: Composition-based stats.
Identities = 70/235 (29%), Positives = 104/235 (44%), Gaps = 14/235 (5%)
Query: 3 VLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVSKS 62
+L+TRP E L +LA AG+ + LPL E + +L N V VSK
Sbjct: 6 LLLTRPAEESAALARVLADAGIFSSSLPLLETEPLPLTPAQRSIIFELLNYSAVIVVSKP 65
Query: 63 AVDFAFKTLTATGFVWRHD--LHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLL---Q 117
A A + + VW +F+VG T Q + +P ++SE LL +
Sbjct: 66 AARLAIELIDE---VWPQPPMQPWFSVGSATGQILL-DYGLDASWPEQGDDSEALLDHPR 121
Query: 118 LNAMQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRA 177
L + VLI+RGN GREL AEQ ++RG V+ + YRR + +
Sbjct: 122 LKQAIAVPGSRVLIMRGNEGRELLAEQLRERGVGVDYLPLYRRYLPQHAPGTLLQRVEVE 181
Query: 178 GIQTIVVTSAEILTQLVDFVPQNEHNW--LKSCQLITVSERIAHLAEALGWQNVV 230
+ +VV+S + L+ +W L L S R+A LA+A G +NV+
Sbjct: 182 RLNGLVVSSGQGFEHLLQLAGD---SWPDLAGLPLFVPSPRVASLAQAAGARNVI 233
>gi|77359076|ref|YP_338651.1| uroporphyrinogen-III synthase [Pseudoalteromonas haloplanktis
TAC125]
gi|76873987|emb|CAI85208.1| uroporphyrinogen-III synthase HemD (N terminal)/Uroporphyrin-III
C-methyltransferase (C terminal) [Pseudoalteromonas
haloplanktis TAC125]
Length = 616
Score = 77.4 bits (189), Expect = 8e-13, Method: Composition-based stats.
Identities = 61/218 (27%), Positives = 98/218 (44%), Gaps = 8/218 (3%)
Query: 1 MAVLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVS 60
+ +L+TRP +G L L +AG A P+ +IE L + + L N D + VS
Sbjct: 2 LNILITRPQGKGAALAQQLEQAGYQASLFPVLKIEY---LTPDSIELSPLTNADKIIFVS 58
Query: 61 KSAVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNA 120
+ AV A L + ++ VGQ TA + P Q +SEGLL L +
Sbjct: 59 QDAV-LALSELKPDINI---KAQFYGVGQQTADTIYEVFGVRAAVPK-QHDSEGLLALKS 113
Query: 121 MQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRAGIQ 180
+ D+ +++++G GGR A+ +QRGA + Y+R PI + +
Sbjct: 114 LADVDSCNIVLVKGIGGRPDIAKTLKQRGAFLNNCVVYQRTPIDPEPNNWIDHWQSQNVH 173
Query: 181 TIVVTSAEILTQLVDFVPQNEHNWLKSCQLITVSERIA 218
IV+TS + + + + WL+ C+ SERI
Sbjct: 174 GIVITSNAAVDAIFKNLAAPQRQWLQQCRFYVASERIG 211
>gi|118696766|ref|ZP_01554847.1| protein of unknown function DUF513, hemX [Burkholderia ambifaria
MC40-6]
gi|118645596|gb|EAV52428.1| protein of unknown function DUF513, hemX [Burkholderia ambifaria
MC40-6]
Length = 655
Score = 76.6 bits (187), Expect = 1e-12, Method: Composition-based stats.
Identities = 77/260 (29%), Positives = 113/260 (43%), Gaps = 27/260 (10%)
Query: 4 LVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVSKSA 63
++TRPD + L LA+AG + PL I + L FA L + V VS +A
Sbjct: 11 VLTRPDGQSAGLSAQLAEAGCDVLEFPLIDIAPVDDPAPLDAAFAALGDYALVIFVSPNA 70
Query: 64 VDFAFKTLTATGFVWRHDLHYFTVGQGT-AQYFTATTEMPVHYPTAQE----------NS 112
+D + L G +W + L VG G+ A P H A + +S
Sbjct: 71 ID---RALAQYGAIWPNALPVGVVGPGSVAALERHGIAAPAHRVIAPQAPADGGVPHYDS 127
Query: 113 EGLLQ-----LNAMQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRR---EPIV 164
E L Q L+ K VLI+RG+GGRE AE+ ++ GA+V +V YRR EP V
Sbjct: 128 ENLFASIEAAFGGAQALAGKRVLIVRGDGGREWLAERLREAGADVTLVAAYRRVVPEPRV 187
Query: 165 YNNAEQTSICKRAGIQTIVVTSAEILTQLVDFVPQN----EHNWLKSCQLITVSERIAHL 220
E+ +VTS+E + L + + E LK L+T RI
Sbjct: 188 -GAWERVHALLAGAPHAWLVTSSEGVRNLHELARTHLNDAEIEALKHAPLVTPHPRIEQT 246
Query: 221 AEALGWQNVVISPRADNQTL 240
A ALG+ + ++ D + +
Sbjct: 247 ARALGFDRITLTGAGDERIV 266
>gi|121591884|ref|ZP_01679048.1| uroporphyrinogen-III synthetase [Vibrio cholerae 2740-80]
gi|121546250|gb|EAX56553.1| uroporphyrinogen-III synthetase [Vibrio cholerae 2740-80]
Length = 120
Score = 76.3 bits (186), Expect = 2e-12, Method: Composition-based stats.
Identities = 45/124 (36%), Positives = 67/124 (54%), Gaps = 4/124 (3%)
Query: 1 MAVLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVS 60
M VLVTRPDE+G +L +L + G+ A+H PL I + +L L + D + AVS
Sbjct: 1 MTVLVTRPDEQGAELCQLLHQQGIPALHHPLLAISASPQLAALAEDLSSF---DIIIAVS 57
Query: 61 KSAVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNA 120
+ AV F+ + L W ++ Y VGQ TA F+ + V YP + SE LL L+
Sbjct: 58 QHAVIFSDQFLQHRRICWPNNAIYLAVGQKTAHVFSKACQQSVDYPEISD-SEHLLALSM 116
Query: 121 MQDL 124
++D+
Sbjct: 117 LRDV 120
>gi|148545466|ref|YP_001265568.1| Uroporphyrinogen-III synthase [Pseudomonas putida F1]
gi|148509524|gb|ABQ76384.1| Uroporphyrinogen-III synthase [Pseudomonas putida F1]
Length = 255
Score = 75.5 bits (184), Expect = 3e-12, Method: Composition-based stats.
Identities = 80/244 (32%), Positives = 111/244 (45%), Gaps = 10/244 (4%)
Query: 3 VLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVSKS 62
+L+TRP E L LA AGV + LPL IE L + + VSK
Sbjct: 6 LLLTRPAEDCAALAQSLAAAGVGSSCLPLLEIEPITVQAPQRLSLEGLHDFQAIIVVSKP 65
Query: 63 AVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNAM- 121
A + L T + +FTVG+ TA + V +P ++SE LL L A+
Sbjct: 66 AARLLLEHLAETS-IQPPQRGWFTVGEATAGVLQGAG-LEVSFPPRGDDSEALLALPALR 123
Query: 122 QDLSDKT--VLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRAGI 179
Q L++ VLI+RG GGREL AE+ ++GA+VE +E YRR Y + +
Sbjct: 124 QALTEPAPRVLIVRGVGGRELLAERLAEQGASVEYLELYRRCLPAYPAGTLMRRIEAERL 183
Query: 180 QTIVVTSAEILTQLVDFVPQNEHNWLKSCQ--LITVSERIAHLAEALGWQNVVISPRADN 237
+VV+S + L +WL+ Q L S R+A A+A G Q VV A
Sbjct: 184 NGLVVSSGQGFEHLQRMAGA---DWLRLAQLPLFVPSPRVAEQAKAAGAQQVVDCRGASA 240
Query: 238 QTLL 241
LL
Sbjct: 241 TALL 244
>gi|115352518|ref|YP_774357.1| protein of unknown function DUF513, hemX [Burkholderia cepacia
AMMD]
gi|115282506|gb|ABI88023.1| protein of unknown function DUF513, hemX [Burkholderia cepacia
AMMD]
Length = 655
Score = 75.5 bits (184), Expect = 3e-12, Method: Composition-based stats.
Identities = 77/260 (29%), Positives = 112/260 (43%), Gaps = 27/260 (10%)
Query: 4 LVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVSKSA 63
++TRPD + L LA+AG + PL I + L FA L V VS +A
Sbjct: 11 VLTRPDGQSAGLSAQLAEAGCDVLEFPLIDIAPVDDPAPLDAAFAALDRYALVIFVSPNA 70
Query: 64 VDFAFKTLTATGFVWRHDLHYFTVGQGT-AQYFTATTEMPVHYPTAQE----------NS 112
+D A A +W + L VG G+ A P H A + +S
Sbjct: 71 IDRALAQYDA---IWPNALPVGVVGPGSVAALERHGIAAPAHRVIAPQAPADGGVPHYDS 127
Query: 113 EGLLQ-----LNAMQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRR---EPIV 164
E L Q L+ K VLI+RG+GGRE AE+ ++ GA+V +V YRR EP V
Sbjct: 128 ENLFASIEAAFGGAQALAGKHVLIVRGDGGREWLAERLREAGADVTLVAAYRRVVPEPRV 187
Query: 165 YNNAEQTSICKRAGIQTIVVTSAEILTQLVDFVPQN----EHNWLKSCQLITVSERIAHL 220
E+ + +VTS+E + L + + E LK L+T RI
Sbjct: 188 -GAWERVHVLLAGAPHAWLVTSSEGVRNLHELARTHLNDAEIEALKHAPLVTPHPRIEQT 246
Query: 221 AEALGWQNVVISPRADNQTL 240
A ALG+ + ++ D + +
Sbjct: 247 ARALGFDRITLTGAGDERIV 266
>gi|26986931|ref|NP_742356.1| uroporphyrinogen-III synthetase [Pseudomonas putida KT2440]
gi|24981541|gb|AAN65820.1|AE016210_8 uroporphyrinogen-III synthetase [Pseudomonas putida KT2440]
Length = 255
Score = 75.1 bits (183), Expect = 3e-12, Method: Composition-based stats.
Identities = 80/244 (32%), Positives = 111/244 (45%), Gaps = 10/244 (4%)
Query: 3 VLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVSKS 62
+L+TRP E L LA AGV + LPL IE L + + VSK
Sbjct: 6 LLLTRPAEDCAALAQSLAAAGVGSSCLPLLEIEPITVQAPQRLSLEGLHDFQAIIVVSKP 65
Query: 63 AVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNAM- 121
A + L T + +FTVG+ TA + V +P ++SE LL L A+
Sbjct: 66 AARLLLEHLAETS-IQPPQRGWFTVGEATAGVLQGAG-LKVCFPPRGDDSEALLALPALR 123
Query: 122 QDLSDKT--VLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRAGI 179
Q L++ VLI+RG GGREL AE+ ++GA+VE +E YRR Y + +
Sbjct: 124 QALTEPAPRVLIVRGVGGRELLAERLAEQGASVEYLELYRRCLPAYPAGTLMRRIEAERL 183
Query: 180 QTIVVTSAEILTQLVDFVPQNEHNWLKSCQ--LITVSERIAHLAEALGWQNVVISPRADN 237
+VV+S + L +WL+ Q L S R+A A+A G Q VV A
Sbjct: 184 NGLVVSSGQGFEHLQQMAGA---DWLRLAQLPLFVPSPRVAEQAKAAGAQQVVDCRGASA 240
Query: 238 QTLL 241
LL
Sbjct: 241 TALL 244
>gi|114321816|ref|YP_743499.1| Uroporphyrinogen III synthase HEM4 [Alkalilimnicola ehrlichei
MLHE-1]
gi|114228210|gb|ABI58009.1| Uroporphyrinogen III synthase HEM4 [Alkalilimnicola ehrlichei
MLHE-1]
Length = 261
Score = 75.1 bits (183), Expect = 3e-12, Method: Composition-based stats.
Identities = 73/248 (29%), Positives = 107/248 (43%), Gaps = 5/248 (2%)
Query: 2 AVLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVSK 61
VLVTRP + L L AG LP I E A L D++ VS
Sbjct: 8 GVLVTRPAHQAAGLCRTLEAAGARVWALPTLEIVPQPESALPAAAVAALGEADWLIFVSP 67
Query: 62 SAVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNAM 121
+AV + G R D VG+GT + P A SE L + A
Sbjct: 68 NAVHHGLACMARHGVRPRPDARIAAVGKGTERALHRVGLSVTAVPQAGFTSEDLAREPAF 127
Query: 122 QDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRR-EPIVYNNAEQTSICKRAG-I 179
D+ + V+I+RG+ GR AE + +GA V + YR P V +A+ +AG +
Sbjct: 128 GDMRGQRVMIVRGDSGRAWLAEHLRGQGAEVAFLAVYRAVRPQV--DAQPVVEALQAGRL 185
Query: 180 QTIVVTSAEILTQLVDFVPQNEHNWLKSCQLITVSERIAHLAEALGWQNVVISPRAD-NQ 238
++++TS L L + + ++ L+TVS RIA AE G V+ R+ ++
Sbjct: 186 HSVIITSVRGLDNLWFMLGDSGRVLVQRRALVTVSPRIARYAEQAGHTGPVVVARSPADE 245
Query: 239 TLLQTLLQ 246
LLQ + Q
Sbjct: 246 DLLQAVHQ 253
>gi|121634572|ref|YP_974817.1| hypothetical protein NMC0730 [Neisseria meningitidis FAM18]
gi|120866278|emb|CAM10019.1| hypothetical protein [Neisseria meningitidis FAM18]
Length = 250
Score = 74.3 bits (181), Expect = 6e-12, Method: Composition-based stats.
Identities = 69/231 (29%), Positives = 104/231 (45%), Gaps = 20/231 (8%)
Query: 3 VLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESG-AELNELPNKFAKLKNGDYVFAVSK 61
+L+ RP R + V+ +A A L IE+ A L LP +A+ D VF VS
Sbjct: 5 MLIVRPSGRAKDDVETCRRAEWQAEVLSPIEIETDKASLKRLPEMYAR---ADAVFWVSP 61
Query: 62 SAVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNAM 121
+AV+ A L + + H +VGQG+ + V P +SE +L+L
Sbjct: 62 TAVETAVPYLNLSDGIKMH----ISVGQGSRRALERCLGRTVIAPDDGNDSEAVLRLPVW 117
Query: 122 QDLSDKT-VLILRGNGGRELFAEQAQQRGANVEIVECY--RREPIVYNNAEQTSICKRAG 178
L + VL +RG+GGR+ Q++G E+ E Y R +P+ + N + +I
Sbjct: 118 NSLPEGARVLFVRGHGGRDFLMNALQEKGFRTEVAEVYFRRHKPLNFQNFQTENIA---- 173
Query: 179 IQTIVVTSAEILTQLVDFVPQNEHNWLKSCQLITVSERIAHLAEALGWQNV 229
+TSAE++ L VP + KS T RI AEAL + V
Sbjct: 174 --AAYITSAELVQSLFAQVPPQFSRFFKSLLYFTHHPRI---AEALKREGV 219
>gi|2580594|gb|AAD13643.1| Gly1ORF2 [Neisseria gonorrhoeae]
Length = 247
Score = 73.9 bits (180), Expect = 7e-12, Method: Composition-based stats.
Identities = 68/231 (29%), Positives = 104/231 (45%), Gaps = 20/231 (8%)
Query: 3 VLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESG-AELNELPNKFAKLKNGDYVFAVSK 61
+L+ RP R + V++ +AG A L IE+ A L LP +A+ D VF VS
Sbjct: 1 MLIVRPSGRAKDDVEVCRRAGWQAEVLSPIEIETDEASLKRLPEMYAR---ADAVFWVSP 57
Query: 62 SAVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNAM 121
+AV+ A L + + H VGQG+ + V P +SE +L+L
Sbjct: 58 AAVETAVPYLNLSDGIKAH----IAVGQGSRRALARYAGAGVFAPEDGNDSEAVLRLPVW 113
Query: 122 QDLSDKT-VLILRGNGGRELFAEQAQQRGANVEIVECY--RREPIVYNNAEQTSICKRAG 178
L + VL +RG+GGR+ Q++G E+ E Y R +P+ + N + +I
Sbjct: 114 NSLPEGARVLSVRGHGGRDFLMNALQEKGFRTEVAEVYFRRHKPLNFQNFQTENIA---- 169
Query: 179 IQTIVVTSAEILTQLVDFVPQNEHNWLKSCQLITVSERIAHLAEALGWQNV 229
+TS E++ L +P + KS T RI AEAL + V
Sbjct: 170 --AAYITSTELVQSLFAQLPPQFSRFFKSLLYFTHHPRI---AEALKREGV 215
>gi|59800803|ref|YP_207515.1| uroporphyrinogen-III synthetase [Neisseria gonorrhoeae FA 1090]
gi|59717698|gb|AAW89103.1| putative uroporphyrinogen-III synthase [Neisseria gonorrhoeae FA
1090]
Length = 254
Score = 73.9 bits (180), Expect = 7e-12, Method: Composition-based stats.
Identities = 68/231 (29%), Positives = 104/231 (45%), Gaps = 20/231 (8%)
Query: 3 VLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESG-AELNELPNKFAKLKNGDYVFAVSK 61
+L+ RP R + V++ +AG A L IE+ A L LP +A+ D VF VS
Sbjct: 8 MLIVRPSGRAKDDVEVCRRAGWQAEVLSPIEIETDEASLKRLPEMYAR---ADAVFWVSP 64
Query: 62 SAVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNAM 121
+AV+ A L + + H VGQG+ + V P +SE +L+L
Sbjct: 65 AAVETAVPYLNLSDGIKAH----IAVGQGSRRALARYAGAGVFAPEDGNDSEAVLRLPVW 120
Query: 122 QDLSDKT-VLILRGNGGRELFAEQAQQRGANVEIVECY--RREPIVYNNAEQTSICKRAG 178
L + VL +RG+GGR+ Q++G E+ E Y R +P+ + N + +I
Sbjct: 121 NSLPEGARVLSVRGHGGRDFLMNALQEKGFRTEVAEVYFRRHKPLNFQNFQTENIA---- 176
Query: 179 IQTIVVTSAEILTQLVDFVPQNEHNWLKSCQLITVSERIAHLAEALGWQNV 229
+TS E++ L +P + KS T RI AEAL + V
Sbjct: 177 --AAYITSTELVQSLFAQLPPQFSRFFKSLLYFTHHPRI---AEALKREGV 222
>gi|153206966|ref|ZP_01945784.1| uroporphyrinogen-III synthase [Coxiella burnetii 'MSU Goat Q177']
gi|154707465|ref|YP_001425475.1| uroporphyrinogen-III synthase [Coxiella burnetii Dugway 7E9-12]
gi|154356751|gb|ABS78213.1| uroporphyrinogen-III synthase [Coxiella burnetii Dugway 7E9-12]
Length = 268
Score = 73.6 bits (179), Expect = 9e-12, Method: Composition-based stats.
Identities = 67/266 (25%), Positives = 117/266 (43%), Gaps = 38/266 (14%)
Query: 3 VLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELP----------------NK 46
+++TRP+ +G+ L + + G I P I+ + N P +K
Sbjct: 11 IMITRPEGQGELLKKAIERRGGAVILFPTLIIKPINKCNYSPFASASFPPSRESGSPDDK 70
Query: 47 FAK---LKNGDYVFAVSKSAVDFAFKTLTATGFVWRHDLHYFTVGQGTA----QYFTATT 99
K L + D + +S +AV + ++ + +G GTA Q +
Sbjct: 71 MTKAGFLNSSDILIFLSANAVKHS------PILNFKAEQKLVAIGTGTAAALFQRGLSVD 124
Query: 100 EMPVHYPTAQENSEGLLQLNAMQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYR 159
+P H+ +SEGLL L + ++ KT+ I G R + RGANV + YR
Sbjct: 125 AVPEHF-----SSEGLLDLPLLHQVTGKTIAIFCGENSRPYLENELIHRGANVFSIITYR 179
Query: 160 RE-PIVYNNAEQTSICKRAGIQTIVVTSAEILTQLVDFVPQNEHNWLKSCQLITVSERIA 218
RE P+V N + + IV TSAE L L ++H WL L+ +S+R+
Sbjct: 180 RERPVV--NKKTIDALTHQTLHAIVSTSAESLQNLCTLFESHQH-WLHRIPLVVISKRME 236
Query: 219 HLAEALGWQNVVISPRADNQTLLQTL 244
+LA++ G+ V+++ + +++ L
Sbjct: 237 NLAKSQGFHLVLLADNPGEKAIIKVL 262
>gi|29655355|ref|NP_821047.1| uroporphyrinogen-III synthase [Coxiella burnetii RSA 493]
gi|29542627|gb|AAO91561.1| uroporphyrinogen-III synthase [Coxiella burnetii RSA 493]
Length = 268
Score = 73.6 bits (179), Expect = 1e-11, Method: Composition-based stats.
Identities = 67/266 (25%), Positives = 117/266 (43%), Gaps = 38/266 (14%)
Query: 3 VLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELP----------------NK 46
+++TRP+ +G+ L + + G I P I+ + N P +K
Sbjct: 11 IMITRPEWQGELLKKAIERRGGAVILFPTLIIKPINKCNYSPFASASFPPSRESGSPDDK 70
Query: 47 FAK---LKNGDYVFAVSKSAVDFAFKTLTATGFVWRHDLHYFTVGQGTA----QYFTATT 99
K L + D + +S +AV + ++ + +G GTA Q +
Sbjct: 71 MTKAGFLNSSDILIFLSANAVKHS------PILNFKAEQKLVAIGTGTAAALFQRGLSVD 124
Query: 100 EMPVHYPTAQENSEGLLQLNAMQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYR 159
+P H+ +SEGLL L + ++ KT+ I G R + RGANV + YR
Sbjct: 125 AVPEHF-----SSEGLLDLPLLHQVTGKTIAIFCGENSRPYLENELIHRGANVFSIITYR 179
Query: 160 RE-PIVYNNAEQTSICKRAGIQTIVVTSAEILTQLVDFVPQNEHNWLKSCQLITVSERIA 218
RE P+V N + + IV TSAE L L ++H WL L+ +S+R+
Sbjct: 180 RERPVV--NKKTIDALTHQTLHAIVSTSAESLQNLCTLFESHQH-WLHRIPLVVISKRME 236
Query: 219 HLAEALGWQNVVISPRADNQTLLQTL 244
+LA++ G+ V+++ + +++ L
Sbjct: 237 NLAKSQGFHLVLLADNPGEKAIIKVL 262
>gi|126359093|ref|ZP_01716089.1| Uroporphyrinogen-III synthase [Pseudomonas putida GB-1]
gi|126316338|gb|EAZ67337.1| Uroporphyrinogen-III synthase [Pseudomonas putida GB-1]
Length = 255
Score = 73.2 bits (178), Expect = 1e-11, Method: Composition-based stats.
Identities = 79/246 (32%), Positives = 107/246 (43%), Gaps = 14/246 (5%)
Query: 3 VLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKF--AKLKNGDYVFAVS 60
+L+TRP E L LA+ GV + LPL IE E P + L + VS
Sbjct: 6 LLLTRPAEDCAALAQSLAEEGVGSSCLPLLAIEPVTL--ETPQRLLLEGLHGFQAIIVVS 63
Query: 61 KSAVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNA 120
K A + L A + +FTVG+ TA + V P ++SE LL L A
Sbjct: 64 KPAARLLLEQL-AKASLQPPRQGWFTVGEATAAVLQGAG-LEVSAPPRGDDSEALLALPA 121
Query: 121 MQDL---SDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRA 177
++ VLI+RG GGREL AE+ ++GA+VE +E YRR VY +
Sbjct: 122 LRQAVAAPAPRVLIVRGVGGRELLAERLAEQGASVEYLELYRRCLPVYPAGTLMRRIEAE 181
Query: 178 GIQTIVVTSAEILTQLVDFVPQNEHNW--LKSCQLITVSERIAHLAEALGWQNVVISPRA 235
+ +VV+S + L +W L L S R+A A A G Q VV A
Sbjct: 182 RLNGLVVSSGQGFEHLQQLAGA---DWPQLARLPLFVPSPRVAEQARAAGAQQVVDCRGA 238
Query: 236 DNQTLL 241
LL
Sbjct: 239 SATALL 244
>gi|83643193|ref|YP_431628.1| Uroporphyrinogen-III synthase [Hahella chejuensis KCTC 2396]
gi|83631236|gb|ABC27203.1| Uroporphyrinogen-III synthase [Hahella chejuensis KCTC 2396]
Length = 260
Score = 73.2 bits (178), Expect = 1e-11, Method: Composition-based stats.
Identities = 69/248 (27%), Positives = 107/248 (43%), Gaps = 7/248 (2%)
Query: 1 MAVLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVS 60
+ VL+TRP L +L + LP IE E + + L +V VS
Sbjct: 12 LRVLLTRPQGENDSLRALLEQNSAEVRVLPAIAIEPLPETQAIKDCILDLDRYTHVICVS 71
Query: 61 KSAVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNA 120
K A + + A + +F +G+ +A + + V+ P SE LL+
Sbjct: 72 KHASRLLLELIDAYWPQAPQGVRWFAIGESSAAPLRSYG-LTVNTPEQGCASEQLLEHPG 130
Query: 121 MQ----DLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKR 176
+Q D VLI++G GGREL E Q+RGA+V +E Y R+ + Y+ E K+
Sbjct: 131 LQARNEDEPPMRVLIVKGCGGRELLTETMQERGAHVATLELYERKTLEYDPNELNEALKQ 190
Query: 177 AGIQTIVVTSAEILTQLVDFVPQNEHNWLKSCQLITVSERIAHLAEALGWQNVVISPRAD 236
+ +V S E L L + W + +I S R+A LA+ N I+P
Sbjct: 191 WRPEVVVTLSGETLLHLCQLGQNIGYAWGDTLFVIP-SARVATLAQE-NRLNYKIAPELS 248
Query: 237 NQTLLQTL 244
++ LL L
Sbjct: 249 DEALLALL 256
>gi|119469645|ref|ZP_01612514.1| uroporphyrinogen-III synthase HemD (N terminal)/Uroporphyrin-III
C-methyltransferase (C terminal) [Alteromonadales
bacterium TW-7]
gi|119446892|gb|EAW28163.1| uroporphyrinogen-III synthase HemD (N terminal)/Uroporphyrin-III
C-methyltransferase (C terminal) [Alteromonadales
bacterium TW-7]
Length = 610
Score = 72.4 bits (176), Expect = 2e-11, Method: Composition-based stats.
Identities = 60/216 (27%), Positives = 99/216 (45%), Gaps = 8/216 (3%)
Query: 3 VLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVSKS 62
+L+TRP+ +G L + L +AG A P+ I L + + L N D + +S+
Sbjct: 4 ILITRPEGKGAALAEQLEQAGYQASLFPVLNINY---LTPSSTQLSPLINADKIIFISQD 60
Query: 63 AVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNAMQ 122
AV K L ++ VGQ TA + P Q +SEG+L L ++
Sbjct: 61 AV----KALAQLKPDINIKAQFYAVGQQTADTIYELFGVRAATPK-QFDSEGVLALKSLA 115
Query: 123 DLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRAGIQTI 182
+ D +++++G GGR A+ ++RGA + Y REP+ + T K + + I
Sbjct: 116 QVDDSNIVLVKGQGGRPDIAKVLKERGAFLNNCVVYEREPVPDLTSNWTDHWKSSNVHGI 175
Query: 183 VVTSAEILTQLVDFVPQNEHNWLKSCQLITVSERIA 218
V+TS + + + + WL+ C SERIA
Sbjct: 176 VITSNAAVDAMFTPLAAQQLQWLQQCHFYVASERIA 211
>gi|95927860|ref|ZP_01310613.1| hypothetical protein CburR_01000441 [Coxiella burnetii RSA 331]
Length = 268
Score = 71.6 bits (174), Expect = 4e-11, Method: Composition-based stats.
Identities = 65/265 (24%), Positives = 117/265 (44%), Gaps = 36/265 (13%)
Query: 3 VLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELP----------------NK 46
+++TRP+ +G+ L + + G I P I+ + N P +K
Sbjct: 11 IMITRPEGQGELLKKAIERRGGAVILFPTLIIKPINKCNYSPFASASFPPSRESGSPDDK 70
Query: 47 FAK---LKNGDYVFAVSKSAVDFAFKTLTATGFVWRHDLHYFTVGQGTA----QYFTATT 99
K L + D + +S +AV + ++ + +G GTA Q +
Sbjct: 71 MTKAGFLNSSDILIFLSANAVKHS------PILNFKAEQKLVAIGTGTAAALFQRGLSVD 124
Query: 100 EMPVHYPTAQENSEGLLQLNAMQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYR 159
+P H+ +SEGLL L + ++ KT+ I G R + RGANV + YR
Sbjct: 125 AVPEHF-----SSEGLLDLPLLHQVTGKTIAIFCGENSRPYLENELIHRGANVFSIITYR 179
Query: 160 REPIVYNNAEQTSICKRAGIQTIVVTSAEILTQLVDFVPQNEHNWLKSCQLITVSERIAH 219
+E V N ++ + + IV TSAE L L ++H WL L+ +S+R+ +
Sbjct: 180 QERPVVNKKTIDALTHQT-LHAIVSTSAESLQNLCTLFESHQH-WLHRIPLVVISKRMEN 237
Query: 220 LAEALGWQNVVISPRADNQTLLQTL 244
LA++ G+ V+++ + +++ L
Sbjct: 238 LAKSQGFHLVLLADNPGEKAIIKVL 262
>gi|94494188|ref|ZP_01301391.1| hypothetical protein Rgryl_01000720 [Rickettsiella grylli]
Length = 262
Score = 71.6 bits (174), Expect = 4e-11, Method: Composition-based stats.
Identities = 66/252 (26%), Positives = 119/252 (47%), Gaps = 16/252 (6%)
Query: 1 MAVLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVS 60
+ VL+TRP + +L + G +H P I + ++ ++ KL + +V +S
Sbjct: 7 LRVLITRPLHQTSELTTQIQNCGGFVVHFPTLEINQVPNIKKINSELKKLNHYHFVIFIS 66
Query: 61 KSAVDFAFKTLTATGFVWRH---DLHYFTVGQGTAQYFTATTEMPVHY-PTAQENSEGLL 116
++V F T + +W H G GT +P H+ P G++
Sbjct: 67 PNSV---FNTAPSIHAIWPHWPCSTKTIATGLGTVSALK-QHHLPSHFHPEKNYTGMGII 122
Query: 117 QLNAMQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRRE-PIVYNNAEQTSICK 175
L+ +Q + K +LI++G GGR + + RGA+V + Y+R+ P + E+ I
Sbjct: 123 NLSILQTIKGKKILIIKGQGGRLNLIKNLKTRGASVNNLVVYKRQLPAI----EKQCIPN 178
Query: 176 RAGIQTIVVTSAEILTQLVDFV-PQNEHNWLKSCQLITVSERIAHLAEALGWQNV-VISP 233
+ I I+ TS L LV + P+ E + K Q++ +S R+A +A+ LG+ + +I+
Sbjct: 179 QEDIDVIICTSGTGLKNLVTLLHPRWESHLFKK-QMLVISPRLAVIAKKLGFVKLPLIAD 237
Query: 234 RADNQTLLQTLL 245
A + +L TL
Sbjct: 238 NASHDAILHTLF 249
>gi|88812445|ref|ZP_01127694.1| uroporphyrinogen III synthase [Nitrococcus mobilis Nb-231]
gi|88790231|gb|EAR21349.1| uroporphyrinogen III synthase [Nitrococcus mobilis Nb-231]
Length = 267
Score = 71.2 bits (173), Expect = 5e-11, Method: Composition-based stats.
Identities = 60/248 (24%), Positives = 104/248 (41%), Gaps = 7/248 (2%)
Query: 3 VLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVSKS 62
++VTRP + + ML AG A+ PL I + + A+L + D + S +
Sbjct: 18 IVVTRPAHQAESFCRMLEHAGANALRCPLLNISATPKTPSFARLRAELASFDLLIFNSPN 77
Query: 63 AVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNAMQ 122
A +F L + + + +G TA P +SE LL+L ++
Sbjct: 78 AANFGLPQLEPQRRL-QGRVKIAAIGAKTAHAIAGLGYSVDIVPATGFDSESLLELPILE 136
Query: 123 DLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIV---YNNAEQTSICKRAGI 179
+ + ILRG+GGREL + RGA V ++ Y R+P + EQ + R+
Sbjct: 137 KVGGMKIAILRGSGGRELAGSVLRSRGAEVSYIQVYERQPPSKEQFEQIEQLLLHNRS-- 194
Query: 180 QTIVVTSAEILTQLVDFVPQNEHNWLKSCQLITVSERIAHLAEALGW-QNVVISPRADNQ 238
+ +TS E L + + L + S RIA +A + G + ++ ++
Sbjct: 195 DAVAITSGEAFLALWSGIGPRLCHLLNQSTFVFGSRRIADVARSKGLCSPIAVAADPSDE 254
Query: 239 TLLQTLLQ 246
+ LL+
Sbjct: 255 AMFAALLE 262
>gi|94311680|ref|YP_584890.1| protein of unknown function DUF513, hemX [Ralstonia metallidurans
CH34]
gi|93355532|gb|ABF09621.1| protein of unknown function DUF513, hemX [Ralstonia metallidurans
CH34]
Length = 693
Score = 70.9 bits (172), Expect = 6e-11, Method: Composition-based stats.
Identities = 76/265 (28%), Positives = 117/265 (44%), Gaps = 32/265 (12%)
Query: 3 VLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVSKS 62
V+VTRP + +QL + L AG+ + PL I A+ L + ++++ V VS +
Sbjct: 6 VVVTRPAGQSRQLTEALQAAGLDVLSFPLLAIGPAADDVPLRAELGRIEDYALVVFVSPN 65
Query: 63 AVDFAFKTLTAT-----GFVWRHDLHYFTVGQGTAQYFTATTEMPVHY------------ 105
AV + TL G W + VG + P Y
Sbjct: 66 AVSYGLDTLAQVQNAPGGARWPESVPVAVVGPSSVVALAERGITPPAYRVIAPAGAQGND 125
Query: 106 ---PTAQENSEGLL-QLNAMQD-LSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRR 160
A+ +SE L +L+ + + VLI+RG+GGRE A++ + GA+VE VE Y R
Sbjct: 126 TAGDAARFDSEALWSELDTSPGAFAGRKVLIIRGSGGREWLADRLRDAGASVEAVEAYSR 185
Query: 161 ---EPIVYN-NAEQTSICKRAGIQTIVVTSAEILTQL-----VDFVPQNEHNWLKSCQLI 211
EP A + S+ A ++TS+E + L + PQ EH LK Q I
Sbjct: 186 TLPEPSGMQWQAVRDSLKPDAPPYAWLLTSSEAVRNLDGLARLHLSPQ-EHERLKQMQCI 244
Query: 212 TVSERIAHLAEALGWQNVVISPRAD 236
RIA A++LG+ +V+ + D
Sbjct: 245 APHARIAAQAQSLGFAHVLPAAPGD 269
>gi|15793945|ref|NP_283767.1| uroporphyrinogen-III synthetase [Neisseria meningitidis Z2491]
gi|121051905|emb|CAM08211.1| hypothetical protein NMA0988 [Neisseria meningitidis Z2491]
Length = 246
Score = 70.9 bits (172), Expect = 7e-11, Method: Composition-based stats.
Identities = 67/231 (29%), Positives = 104/231 (45%), Gaps = 20/231 (8%)
Query: 3 VLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIES-GAELNELPNKFAKLKNGDYVFAVSK 61
+L+ RP R + V+ +AG A L IE+ A L L ++A+ D VF VS
Sbjct: 1 MLIVRPSGRAKDDVETCRRAGWQAEVLSPIEIEADAAGLELLSEQYAR---ADAVFWVSP 57
Query: 62 SAVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNAM 121
+AV+ A L + + H +VGQG+ + V P +SE +L+L
Sbjct: 58 TAVETAVPYLNLSDGIKMH----ISVGQGSRRVLERCLGRTVIAPEDGNDSEAVLRLTVW 113
Query: 122 QDLSDKT-VLILRGNGGRELFAEQAQQRGANVEIVECY--RREPIVYNNAEQTSICKRAG 178
L + VL +RG+GGR+ Q++G E+ E Y R +P+ + N + +I
Sbjct: 114 NSLPEGARVLFVRGHGGRDFLMNALQEKGFRTEVAEVYFRRHKPLNFQNFQTENIA---- 169
Query: 179 IQTIVVTSAEILTQLVDFVPQNEHNWLKSCQLITVSERIAHLAEALGWQNV 229
+TS E++ L +P + KS T RI AEAL + V
Sbjct: 170 --AAYITSTELVRLLFGQLPPQFSRFFKSLLYFTHHPRI---AEALKREGV 215
>gi|71737073|ref|YP_272378.1| uroporphyrinogen-III synthetase [Pseudomonas syringae pv.
phaseolicola 1448A]
gi|71557626|gb|AAZ36837.1| uroporphyrinogen-III synthetase [Pseudomonas syringae pv.
phaseolicola 1448A]
Length = 257
Score = 70.5 bits (171), Expect = 8e-11, Method: Composition-based stats.
Identities = 67/238 (28%), Positives = 107/238 (44%), Gaps = 20/238 (8%)
Query: 3 VLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVSKS 62
+L+TRP E L +LA+AG+ + LPL E + +L N V VSK
Sbjct: 6 LLLTRPAEESAALAKVLAEAGIFSSSLPLLETEPLPLTPAQRSIIFELLNYCAVIVVSKP 65
Query: 63 AVDFAFKTLTATGFVWRHD--LHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNA 120
A A + + VW +F+VG T Q + +P ++SE LL+L
Sbjct: 66 AARLAIELIDE---VWPQPPMQPWFSVGSATGQILL-DYGLDASWPEQGDDSEALLELPR 121
Query: 121 MQD---LSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRA 177
++ + VLI+RG+ GREL AEQ + G V+ + YRR ++ +R
Sbjct: 122 LKQAIAVPGSRVLIMRGDEGRELLAEQLRALGVGVDYLPLYRR---YLPEHAPDAVPQRV 178
Query: 178 GIQT---IVVTSAEILTQLVDFVPQNEHNW--LKSCQLITVSERIAHLAEALGWQNVV 230
++ +VV+S + L+ +W L L S R+A +A+A G + V+
Sbjct: 179 AVERLNGLVVSSGQGFEHLLQLAGD---SWPDLADLPLFVPSPRVASIAQAAGARTVI 233
>gi|119856254|ref|ZP_01637687.1| Uroporphyrinogen-III synthase [Pseudomonas putida W619]
gi|119817213|gb|EAX19956.1| Uroporphyrinogen-III synthase [Pseudomonas putida W619]
Length = 255
Score = 70.5 bits (171), Expect = 9e-11, Method: Composition-based stats.
Identities = 78/245 (31%), Positives = 111/245 (45%), Gaps = 12/245 (4%)
Query: 3 VLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVSKS 62
+L+TRP+E L LA AG+ + LPL IE + A L + VSK
Sbjct: 6 LLLTRPEEDCAALAQTLATAGICSECLPLLAIEPVQLGARQRQQLAGLGQCQAMIVVSKP 65
Query: 63 AVDFAFKTLTATGFVWRHDLH-YFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNAM 121
A L G + L +FTVG+ TA + + V YP ++SE LL L A+
Sbjct: 66 AARLLLAQLAHEGL--QPPLAGWFTVGEATAAVLQSAG-LTVTYPAQGDDSEALLTLPAL 122
Query: 122 QDL---SDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRAG 178
+ VLI+RG GGREL AE+ ++GA+V+ +E YRR VY +
Sbjct: 123 RGAMAGPAPRVLIVRGVGGRELLAERLAEQGASVDYLELYRRCLPVYPAGTLVRRIEAER 182
Query: 179 IQTIVVTSAEILTQLVDFVPQNEHNWLKSCQ--LITVSERIAHLAEALGWQNVVISPRAD 236
+ +VV+S + L L +W + + L S R+A A A G Q +V A
Sbjct: 183 LNGVVVSSGQGLEHLQQLAAA---DWPRVARLPLFVPSPRVAEQARAAGAQQIVDCRGAS 239
Query: 237 NQTLL 241
LL
Sbjct: 240 ATALL 244
>gi|66043332|ref|YP_233173.1| uroporphyrinogen-III synthetase [Pseudomonas syringae pv. syringae
B728a]
gi|63254039|gb|AAY35135.1| Uroporphyrinogen-III synthase [Pseudomonas syringae pv. syringae
B728a]
Length = 257
Score = 70.1 bits (170), Expect = 1e-10, Method: Composition-based stats.
Identities = 67/238 (28%), Positives = 106/238 (44%), Gaps = 20/238 (8%)
Query: 3 VLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVSKS 62
+L+TRP E L +LA+AG+ + LPL E + +L N V VSK
Sbjct: 6 LLLTRPAEESAALARVLAEAGIFSSSLPLLETEPLPLTPAQRSIIFELLNYCAVIVVSKP 65
Query: 63 AVDFAFKTLTATGFVWRHD--LHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNA 120
A A + + VW +F+VG T Q + +P ++SE LL+L
Sbjct: 66 AARLAIELIDE---VWPQPPLQPWFSVGSATGQILV-DYGLDASWPEQGDDSEALLELPR 121
Query: 121 MQD---LSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRA 177
++ + VLI+RG+ GREL AEQ + G V+ + YRR ++ +R
Sbjct: 122 LKQAIAVPGSRVLIMRGDEGRELLAEQLRALGVGVDYLPLYRR---YLPQHAPGALAQRV 178
Query: 178 GIQT---IVVTSAEILTQLVDFVPQNEHNW--LKSCQLITVSERIAHLAEALGWQNVV 230
++ +VV+S + L+ +W L L S R+A +A A G + V+
Sbjct: 179 AVERLNGLVVSSGQGFEHLLQLAGD---SWPDLADLPLFVPSPRVASIARAAGARTVI 233
>gi|134296606|ref|YP_001120341.1| protein of unknown function DUF513, hemX [Burkholderia
vietnamiensis G4]
gi|134139763|gb|ABO55506.1| protein of unknown function DUF513, hemX [Burkholderia
vietnamiensis G4]
Length = 660
Score = 69.7 bits (169), Expect = 1e-10, Method: Composition-based stats.
Identities = 77/260 (29%), Positives = 115/260 (44%), Gaps = 27/260 (10%)
Query: 4 LVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVSKSA 63
++TRPD + L LA AG + PL I + L FA L + V VS +A
Sbjct: 11 VLTRPDGQSAALAAQLADAGCDVLEFPLIDIAPLDDPAPLVAAFATLADYALVIFVSPNA 70
Query: 64 VDFAFKTLTATGFVWRHDLHYFTVGQGT----AQYFTATTEMPVHYPTA-------QENS 112
+D + L G +W + L VG G+ A++ A V P A + +S
Sbjct: 71 ID---RALAHYGAIWPNALPVGVVGPGSVAALARHGIAAPAHRVIAPQAGADGGVPRYDS 127
Query: 113 EGLLQ-----LNAMQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRR---EPIV 164
E L Q L+ K VLI+RG+GGRE AE+ ++ GA V +V YRR EP V
Sbjct: 128 ESLFACIEAAFGGAQALAGKRVLIVRGDGGREWLAERLREAGAEVTLVAAYRRVVPEPRV 187
Query: 165 YNNAEQTSICKRAGIQTIVVTSAEILTQLVDFVPQN----EHNWLKSCQLITVSERIAHL 220
E+ +VTS+E + L + + E + LK +L+ RI
Sbjct: 188 -GAWERVHALLAGAPHAWLVTSSEGVRNLHELARTHLNDAEIDALKHARLLAPHPRIEQT 246
Query: 221 AEALGWQNVVISPRADNQTL 240
A ALG+ + ++ D + +
Sbjct: 247 ARALGFDRITLTGAGDERIV 266
>gi|118594155|ref|ZP_01551502.1| uroporphyrinogen III methylase [Methylophilales bacterium HTCC2181]
gi|118439933|gb|EAV46560.1| uroporphyrinogen III methylase [Methylophilales bacterium HTCC2181]
Length = 247
Score = 69.3 bits (168), Expect = 2e-10, Method: Composition-based stats.
Identities = 61/253 (24%), Positives = 108/253 (42%), Gaps = 21/253 (8%)
Query: 1 MAVLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVS 60
+A++ TRP R + + V + PL I E E L + ++ +S
Sbjct: 4 VALISTRP-VRKEISPTFYEENNVTFLPFPLTEILPLKEYEEFDLILQNLSSYHHLIFIS 62
Query: 61 KSAVDFAFKTLTATGFVWRHDLHYFT---------VGQGTAQYFTATTEMPVHYPTAQEN 111
+AVDF FV R + ++ T +G T + PV YP +
Sbjct: 63 TNAVDF---------FVARMNFYHITLPSSLIISCIGPSTKKLLQENFNTPVFYPRESFD 113
Query: 112 SEGLLQLNAMQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQT 171
SE LL+ + D+ ++ +LI+RG GGRE + +++G + ECY R+ + + E
Sbjct: 114 SEHLLKSDIFSDIKNQKILIIRGIGGRETLRKGLEKKGGLITYGECYTRKYLQIDLEEVR 173
Query: 172 SICKRAGIQTIVVTSAEILTQLVDFVPQNEHNWLKSCQLITVSERIAHLAEALGWQNVVI 231
+++TS E + + + WLKS +I R+ + E + N+ I
Sbjct: 174 KSTYEFNRIFMLITSYESAKKFMQHNITDHLGWLKSIHVIVNHIRLKN--ELNIFSNITI 231
Query: 232 SPRADNQTLLQTL 244
+ N ++L+ L
Sbjct: 232 TEDLSNDSILRIL 244
>gi|73540407|ref|YP_294927.1| uroporphyrinogen-III synthetase [Ralstonia eutropha JMP134]
gi|72117820|gb|AAZ60083.1| Uroporphyrinogen III synthase HEM4:Protein of unknown function
DUF513, hemX [Ralstonia eutropha JMP134]
Length = 689
Score = 69.3 bits (168), Expect = 2e-10, Method: Composition-based stats.
Identities = 73/265 (27%), Positives = 112/265 (42%), Gaps = 31/265 (11%)
Query: 3 VLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVSKS 62
V+VTRP + +QL + L AG+ + PL I A+ L A+L V VS +
Sbjct: 6 VVVTRPAGQSRQLTEALQAAGLDVLGFPLLSIGPAADDAPLRAALARLDQFALVIFVSPN 65
Query: 63 AVDFAFKTLTATGFV----WRHDLHYFTVGQGT----AQYFTATTEMPVHYPT------- 107
A+ +A L + W + VG + A+ + V P
Sbjct: 66 AIQYAVDALAVVQGIAAAQWPPGVPVAVVGPASVMALAERGIVAPDYRVIAPAGADGNGT 125
Query: 108 --------AQENSEGLLQLNAMQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYR 159
A+ +SE L L ++VLI+RGNGGR+ ++ ++ GA+V VE Y+
Sbjct: 126 NGGANCEEARFDSEALWAQLEPAALQGRSVLIVRGNGGRDWLGDRLREAGADVTAVEAYQ 185
Query: 160 R---EPIVYN-NAEQTSICKRAGIQTIVVTSAEILTQLVDFVPQN----EHNWLKSCQLI 211
R EP A + + A Q ++TS+E + L N E LK Q I
Sbjct: 186 RTLPEPTAMQWQAVRDGLSPGAAPQAWLLTSSEAVRNLETLARHNLSPQELATLKQVQCI 245
Query: 212 TVSERIAHLAEALGWQNVVISPRAD 236
RIA A+ALG+ ++ + D
Sbjct: 246 APHARIAEQAQALGFTRILRAAPGD 270
>gi|152981768|ref|YP_001352833.1| uroporphyrinogen-III synthase [Janthinobacterium sp. Marseille]
gi|151281845|gb|ABR90255.1| uroporphyrinogen-III synthase [Janthinobacterium sp. Marseille]
Length = 256
Score = 68.2 bits (165), Expect = 4e-10, Method: Composition-based stats.
Identities = 70/256 (27%), Positives = 112/256 (43%), Gaps = 16/256 (6%)
Query: 3 VLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVSKS 62
V++TRP + L + + G A+ PL I + L +L + VS +
Sbjct: 5 VVITRPLAQADALAQRVTELGRKAVIFPLLEILPLDDQQSLRQALRELDQYALIAFVSPN 64
Query: 63 AVDFAFKTLTATGFVWRHDLHYFTVGQGTA----QYFTATTEMPVHYPTAQE--NSEGLL 116
A+D AF W + VG+G+ ++ T + PT E +S+ LL
Sbjct: 65 AIDAAFNARPD----WPWQIPLAVVGEGSRMALLRHGATTGNSTIISPTDLERTDSQTLL 120
Query: 117 QLNAMQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKR 176
+ L K VLI+RG GREL + + G V + YRR NNA + + +
Sbjct: 121 AELDLPVLRGKQVLIIRGETGRELLGDTLRAAGVGVTPLAAYRRVAPELNNARRGELKRL 180
Query: 177 AGIQT-IVVTSAEILTQLVDFVPQNEHNW----LKSCQLITVSERIAHLAEALGWQNVVI 231
Q +VTS+E L L + V Q + ++ ++I RIA A+ LG+ N+ +
Sbjct: 181 LSCQNDWIVTSSEGLRFLTEMVAQLDEAGSVAKMQQQRIIVSHVRIAETAQLLGFSNITL 240
Query: 232 SPRADNQTLLQTLLQC 247
+ R+ + LL L C
Sbjct: 241 T-RSGDDGLLAALQSC 255
>gi|145588842|ref|YP_001155439.1| Uroporphyrinogen III synthase HEM4 [Polynucleobacter sp.
QLW-P1DMWA-1]
gi|145047248|gb|ABP33875.1| Uroporphyrinogen III synthase HEM4 [Polynucleobacter sp.
QLW-P1DMWA-1]
Length = 274
Score = 67.8 bits (164), Expect = 6e-10, Method: Composition-based stats.
Identities = 71/269 (26%), Positives = 122/269 (45%), Gaps = 32/269 (11%)
Query: 3 VLVTRPDERGQQLVDMLAK---AGVVA-------IHLPLFRIESGAELNELPNKFAKLKN 52
+++TRP + +QL+++L K A +A + LPL I ++ + + + L++
Sbjct: 6 IVITRPTGQARQLIEVLTKVIEASAIAKRSLPELVSLPLLTIVPKSDEHLADSIASTLQD 65
Query: 53 GDYVFAVSKSAV------------DFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTE 100
D VS +AV DF+ + + L G G Y T+
Sbjct: 66 ADLAIFVSPNAVESVMRLLERDWQDFSKRIIPIGVMGGSSRLALKNHGIGQEDYPTS--- 122
Query: 101 MPVHYPTAQE--NSEGLLQ-LNAMQ-DLSDKTVLILRGNGGRELFAEQAQQRGANVEIVE 156
++ P+ E +SEGL Q L + D + K V+I +G+GGRE A+ Q+ GA VE +
Sbjct: 123 --IYMPSINERWDSEGLWQELQTLDWDWTHKKVVIFKGDGGREWLADTLQKAGATVEAIS 180
Query: 157 CYRREPIVYNNAEQTSICKRAGIQTI-VVTSAEILTQLVDFVPQNEHNWLKSCQLITVSE 215
Y R P+ +N I + +++ ++TS+E + L + + L+S +
Sbjct: 181 TYTRVPLDIDNPAWQVIHEMDFSKSLWLLTSSEAVRYLGEVIRDQFPYGLESASALCPHH 240
Query: 216 RIAHLAEALGWQNVVISPRADNQTLLQTL 244
IA AEA+G+ V S D + TL
Sbjct: 241 NIADAAEAIGFGEVFTSEPGDEALIKTTL 269
>gi|78484458|ref|YP_390383.1| uroporphyrinogen III methylase [Thiomicrospira crunogena XCL-2]
gi|78362744|gb|ABB40709.1| uroporphyrinogen III methylase [Thiomicrospira crunogena XCL-2]
Length = 264
Score = 67.8 bits (164), Expect = 6e-10, Method: Composition-based stats.
Identities = 67/257 (26%), Positives = 111/257 (43%), Gaps = 16/257 (6%)
Query: 1 MAVLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFA-KLKNGDYVFAV 59
+ L TRP E+ + L + + G + P +I LP + L D VF +
Sbjct: 8 LTFLNTRPVEQAEALSQSVREKGHQVLACPTLKICP----RSLPQQAGVTLSTFDKVFFI 63
Query: 60 SKSAVDF---AFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLL 116
S++AV +++ T V+ F +GQ T A + Q +E LL
Sbjct: 64 SQNAVKQFVDMWQSAYQTHPVFAEKTECFAIGQSTYNAMKALDWPVAKVHSNQYVTEALL 123
Query: 117 QLNAMQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKR 176
Q +Q+L+D+ LI++G GGR AE GA V Y R P + +A Q + +
Sbjct: 124 QSEVLQNLTDQQCLIVKGKGGRPTLAEGLIAAGATVTEWAVYERVPADFCDA-QWQVFRS 182
Query: 177 AGIQTIVVTS------AEILTQLVDFVPQNEHNWLKSCQLITVSERIAHLAEALGWQN-V 229
A ++++S E + + + +N+ WL +I S+RI H + WQ +
Sbjct: 183 ARHPVLLISSLDAWYGLEKMLKNSGYGSKNDQAWLFLQDVIVFSDRIKHALQQQEWQGRL 242
Query: 230 VISPRADNQTLLQTLLQ 246
+ P+ N +L L Q
Sbjct: 243 FVVPQQSNAGILTALEQ 259
>gi|78067220|ref|YP_369989.1| uroporphyrinogen-III synthetase [Burkholderia sp. 383]
gi|77967965|gb|ABB09345.1| conserved hypothetical protein [Burkholderia sp. 383]
Length = 656
Score = 67.0 bits (162), Expect = 8e-10, Method: Composition-based stats.
Identities = 74/260 (28%), Positives = 114/260 (43%), Gaps = 27/260 (10%)
Query: 4 LVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVSKSA 63
++TRPD + L LA+AG + PL I + L FA L + V VS +A
Sbjct: 11 VLTRPDGQSGALASQLAEAGCDVLEFPLIDIAPVDDPAPLDAAFAALADYTLVIFVSPNA 70
Query: 64 VDFAFKTLTATGFVWRHDLHYFTVGQGT-AQYFTATTEMPVHYPTAQE----------NS 112
+D + L G +W + L VG G+ A P H A + +S
Sbjct: 71 ID---RALAQYGAIWPNALPVGVVGPGSVAALERHGIAAPAHRVIAPQAPADGGVPHYDS 127
Query: 113 EGLLQ-----LNAMQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRR---EPIV 164
E L Q L+ K VLI+RG+GGRE A++ ++ GA+V +V YRR +P V
Sbjct: 128 ESLFACIETAFGGAQALAGKRVLIVRGDGGREWLADRLREAGADVTLVAAYRRVVPDPRV 187
Query: 165 YNNAEQTSICKRAGIQTIVVTSAEILTQLVDFVPQN----EHNWLKSCQLITVSERIAHL 220
E+ +VTS+E + L + + E + LK L+T RI
Sbjct: 188 -GAWERVHALLHGEPHAWLVTSSEGVRNLHELARSHLNDAEIDALKHAPLVTPHPRIEQT 246
Query: 221 AEALGWQNVVISPRADNQTL 240
A +LG+ + ++ D + +
Sbjct: 247 ARSLGFDRITLTGAGDERIV 266
>gi|115423375|emb|CAJ49909.1| uroporphyrinogen-III synthase [Bordetella avium 197N]
Length = 266
Score = 66.6 bits (161), Expect = 1e-09, Method: Composition-based stats.
Identities = 65/225 (28%), Positives = 105/225 (46%), Gaps = 23/225 (10%)
Query: 1 MAVLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFA-KLKNGDYVFAV 59
+AVL TRP+ R + L L AG LP RI + LP A + ++ D V V
Sbjct: 11 LAVL-TRPEGRNEALAGRLRAAGWEVCVLPALRIVA------LPAPRAPRPEDYDLVVFV 63
Query: 60 SKSAVDFAFKTLTATGFVWRHDLHYFTVGQGTAQ------YFTATTEMPVHYP---TAQE 110
S +A K + A+ W TVG G+AQ YF A T V YP
Sbjct: 64 SGNAARLYLKQVYASAGAWPAATVAATVGPGSAQALFESGYFGANTT--VLYPDISAPTH 121
Query: 111 NSEGLLQLNAMQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQ 170
+SE L Q+ + Q + VL++RG GR AE+ ++ GA V Y+R P ++ A
Sbjct: 122 DSEALWQVLSAQGALPRRVLLVRGTQGRNWLAERLREAGAQVTAYAAYQRLPAQWDAATL 181
Query: 171 TSI---CKRAGIQTIVVTSAEILTQLVDFVPQNE-HNWLKSCQLI 211
++ ++ + T ++TS E + + + + + +W ++C+ +
Sbjct: 182 DALRAWARQGRVATWLLTSGESIDAVAAQIARADLLSWWRNCRYV 226
>gi|119876160|ref|ZP_01643211.1| Uroporphyrinogen III synthase HEM4 [Stenotrophomonas maltophilia
R551-3]
gi|119821201|gb|EAX23799.1| Uroporphyrinogen III synthase HEM4 [Stenotrophomonas maltophilia
R551-3]
Length = 269
Score = 65.9 bits (159), Expect = 2e-09, Method: Composition-based stats.
Identities = 44/147 (29%), Positives = 73/147 (49%), Gaps = 2/147 (1%)
Query: 84 YFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNAMQDLSDKTVLILRGNGGRELFAE 143
+ TVG+GTA+ A VH P + +SEGLL L + D+ + + ++ GGR L A
Sbjct: 99 WLTVGEGTARALRAQGVHEVHAPQ-RMDSEGLLALPVLADVRGRRIGLVTAPGGRGLIAA 157
Query: 144 QAQQRGANVEIVECYRREPIVYNNAEQTSICKRAGIQTIVVTSAEILTQLVDFVPQNEHN 203
Q Q GA++E + Y+R P+ + + A + V+S E L +P
Sbjct: 158 QLQAAGASIERADVYQRRPLRLSPRTLARLAHSAYPWVLAVSSGEALQHFWRQLPHALQQ 217
Query: 204 WLKS-CQLITVSERIAHLAEALGWQNV 229
L++ ++ S+R+ A+ALG Q +
Sbjct: 218 RLQAHASVVVASDRLREQAQALGLQRI 244
>gi|15676675|ref|NP_273819.1| uroporphyrinogen-III synthetase [Neisseria meningitidis MC58]
gi|7226008|gb|AAF41190.1| putative uroporphyrinogen-III synthase HemD [Neisseria meningitidis
MC58]
Length = 246
Score = 64.3 bits (155), Expect = 6e-09, Method: Composition-based stats.
Identities = 66/231 (28%), Positives = 101/231 (43%), Gaps = 20/231 (8%)
Query: 3 VLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIES-GAELNELPNKFAKLKNGDYVFAVSK 61
+L+ RP R + V+ AG A L IE+ A L L ++A+ D VF VS
Sbjct: 1 MLIVRPSGRAAEDVETCLNAGWRAEVLSPVEIEADAAGLELLSEQYAR---ADAVFWVSP 57
Query: 62 SAVDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNAM 121
+AV+ A L + + VGQG+ + V P +SE +L+L
Sbjct: 58 TAVETAVPYLNLSDGIKAQ----IAVGQGSRRALERCLVRTVIAPDDGNDSEAVLRLPVW 113
Query: 122 QDLSDKT-VLILRGNGGRELFAEQAQQRGANVEIVECY--RREPIVYNNAEQTSICKRAG 178
L + VL +RG+GGR+ Q++G E+ E Y R +P+ + N + +I
Sbjct: 114 NSLPEGARVLFVRGHGGRDFLMNALQEKGFRTEVAEVYFRRHKPLNFQNFQTENIA---- 169
Query: 179 IQTIVVTSAEILTQLVDFVPQNEHNWLKSCQLITVSERIAHLAEALGWQNV 229
+TS E++ L +P + KS T RI AEAL + V
Sbjct: 170 --AAYITSTELVRLLFGQLPPQFSRFFKSLLYFTHHPRI---AEALKREGV 215
>gi|118719131|ref|ZP_01571662.1| protein of unknown function DUF513, hemX [Burkholderia multivorans
ATCC 17616]
gi|118657437|gb|EAV64186.1| protein of unknown function DUF513, hemX [Burkholderia multivorans
ATCC 17616]
Length = 656
Score = 63.2 bits (152), Expect = 1e-08, Method: Composition-based stats.
Identities = 73/260 (28%), Positives = 109/260 (41%), Gaps = 27/260 (10%)
Query: 4 LVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVSKSA 63
++TRPD + L LA AG + PL I + L FA L + V VS +A
Sbjct: 11 VLTRPDGQSAGLAAQLADAGCDVLEFPLIDIAPVDDPAPLAAAFAALADYALVIFVSPNA 70
Query: 64 VDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHY-----------PTAQENS 112
+D + L G +W + L VG G+ P Y +S
Sbjct: 71 ID---RALAQYGAIWPNALPVGVVGPGSVAALERHGIAPPAYRVIAPQPGSDGSAPHYDS 127
Query: 113 EGLL-----QLNAMQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRR---EPIV 164
EGL L+ K VLI+RG+GGRE A++ ++ GA+V +V YRR EP +
Sbjct: 128 EGLFASIEAAFGGAAALAGKRVLIVRGDGGREWLADRLREAGADVTLVAAYRRVVPEPRI 187
Query: 165 YNNAEQTSICKRAGIQTIVVTSAEILTQLVDF----VPQNEHNWLKSCQLITVSERIAHL 220
E+ +VTS+E + L + + E LK L+T RI
Sbjct: 188 -GTWERVHALLGGEPHAWLVTSSEGVRNLHELARAHLNDTEIEALKHAPLVTPHPRIEQT 246
Query: 221 AEALGWQNVVISPRADNQTL 240
A ALG+ + ++ D + +
Sbjct: 247 ARALGFDRITLTGAGDERIV 266
>gi|51245586|ref|YP_065470.1| uroporphyrinogen III synthase/methyltransferase (HemD+CobA)
[Desulfotalea psychrophila LSv54]
gi|50876623|emb|CAG36463.1| probable uroporphyrinogen III synthase/methyltransferase
(HemD+CobA) [Desulfotalea psychrophila LSv54]
Length = 520
Score = 62.4 bits (150), Expect = 3e-08, Method: Composition-based stats.
Identities = 53/218 (24%), Positives = 89/218 (40%), Gaps = 9/218 (4%)
Query: 3 VLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVSKS 62
++VTR E+ +LV L + G + +I E EL N +L+ ++ S +
Sbjct: 265 IIVTRTREQASELVQELEEQGANCLECATIKISPIKEPKELDNALERLQEFHWILFTSIN 324
Query: 63 AVDFAFKTLTATGFVWRHDLH---YFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLN 119
V + F+ L + G R DL VG TA Y +P EGL Q
Sbjct: 325 GVKYFFERLFSKGMDAR-DLKGCDIAVVGPSTADYLRKYGLNADLFPPVF-TGEGLAQAL 382
Query: 120 AMQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRAGI 179
Q + + +LI R RE+ E + GA V + Y +PI N E + + +
Sbjct: 383 LDQGVEGRNILIPRAQQAREIVPENLRGAGAQVTVAPVYVTKPIAENKKEMRAELESGTV 442
Query: 180 QTIVVTSAEILTQLVDFV----PQNEHNWLKSCQLITV 213
+ TS+ +T + + P+ + LK ++ +
Sbjct: 443 DMVTFTSSSTVTNFIKMLQPESPEELASLLKGVRIAAI 480
>gi|84355413|ref|ZP_00980297.1| COG2959: Uncharacterized enzyme of heme biosynthesis [Burkholderia
cenocepacia PC184]
Length = 656
Score = 60.8 bits (146), Expect = 8e-08, Method: Composition-based stats.
Identities = 77/260 (29%), Positives = 114/260 (43%), Gaps = 27/260 (10%)
Query: 4 LVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVSKSA 63
++TRPD + L LA AG + PL I + L FA L + V VS +A
Sbjct: 11 VLTRPDGQSDALAAQLADAGCDVLEFPLIDIAPVDDPAPLDAAFAALADYALVIFVSPNA 70
Query: 64 VDFAFKTLTATGFVWRHDLHYFTVGQGT-AQYFTATTEMPVHYPTAQE----------NS 112
+D A A +W + L VG G+ A P H A + +S
Sbjct: 71 IDRALARYDA---IWPNALPVGVVGPGSVAALERHGIAAPAHRVIAPQAPADGGVPHYDS 127
Query: 113 EGL-----LQLNAMQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRR---EPIV 164
E L + Q L+ K VLI+RG+GGRE AE+ ++ GA+V +V YRR EP V
Sbjct: 128 ESLFASIEVAFGGAQALAGKRVLIVRGDGGREWLAERLREAGADVTLVAAYRRVVPEPRV 187
Query: 165 YNNAEQTSICKRAGIQTIVVTSAEILTQLVDF----VPQNEHNWLKSCQLITVSERIAHL 220
E+ +VTS+E + L + + + E + LK L+T RI
Sbjct: 188 -GAWERVHALLDGQPHGWLVTSSEGVRNLHELARAHLNEAEIDALKHAPLVTPHPRIEQT 246
Query: 221 AEALGWQNVVISPRADNQTL 240
A ALG+ + ++ D + +
Sbjct: 247 ARALGFDRITLTGAGDERIV 266
>gi|107023361|ref|YP_621688.1| protein of unknown function DUF513, hemX [Burkholderia cenocepacia
AU 1054]
gi|116690444|ref|YP_836067.1| protein of unknown function DUF513, hemX [Burkholderia cenocepacia
HI2424]
gi|105893550|gb|ABF76715.1| protein of unknown function DUF513, hemX [Burkholderia cenocepacia
AU 1054]
gi|116648533|gb|ABK09174.1| protein of unknown function DUF513, hemX [Burkholderia cenocepacia
HI2424]
Length = 656
Score = 60.5 bits (145), Expect = 8e-08, Method: Composition-based stats.
Identities = 77/260 (29%), Positives = 114/260 (43%), Gaps = 27/260 (10%)
Query: 4 LVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVSKSA 63
++TRPD + L LA AG + PL I + L FA L + V VS +A
Sbjct: 11 VLTRPDGQSDALAAQLADAGCDVLEFPLIDIAPVDDPAPLDAAFAALADYALVIFVSPNA 70
Query: 64 VDFAFKTLTATGFVWRHDLHYFTVGQGT-AQYFTATTEMPVHYPTAQE----------NS 112
+D A A +W + L VG G+ A P H A + +S
Sbjct: 71 IDRALARYDA---IWPNALPVGVVGPGSVAALERHGIAAPAHRVIAPQAPADGGVPHYDS 127
Query: 113 EGL-----LQLNAMQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRR---EPIV 164
E L + Q L+ K VLI+RG+GGRE AE+ ++ GA+V +V YRR EP V
Sbjct: 128 ESLFASIEVAFGGAQALAGKRVLIVRGDGGREWLAERLREAGADVTLVAAYRRVVPEPRV 187
Query: 165 YNNAEQTSICKRAGIQTIVVTSAEILTQLVDF----VPQNEHNWLKSCQLITVSERIAHL 220
E+ +VTS+E + L + + + E + LK L+T RI
Sbjct: 188 -GAWERVHALLDGQPHGWLVTSSEGVRNLHELARAHLNEAEIDALKHAPLVTPHPRIEQT 246
Query: 221 AEALGWQNVVISPRADNQTL 240
A ALG+ + ++ D + +
Sbjct: 247 ARALGFDRITLTGAGDERIV 266
>gi|84362557|ref|ZP_00987176.1| COG2959: Uncharacterized enzyme of heme biosynthesis [Burkholderia
dolosa AUO158]
gi|124894315|gb|EAY68195.1| hypothetical protein BDAG_00902 [Burkholderia dolosa AUO158]
Length = 656
Score = 59.7 bits (143), Expect = 1e-07, Method: Composition-based stats.
Identities = 72/260 (27%), Positives = 112/260 (43%), Gaps = 27/260 (10%)
Query: 4 LVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVSKSA 63
++TRPD + L LA+AG + PL I + L A L + V VS +A
Sbjct: 11 VLTRPDGQSAGLAAQLAEAGCDVLEFPLIDIAPVDDPAPLDAALAALADYALVIFVSPNA 70
Query: 64 VDFAFKTLTATGFVWRHDLHYFTVGQGTAQYFT-------ATTEMPVHYPT----AQENS 112
++ A A +W + L VG G+ A + H PT + +S
Sbjct: 71 IERALARYDA---IWPNALPIGVVGPGSVAALERHGIAAPAHRVIAPHAPTDGGVPRYDS 127
Query: 113 EGLL-----QLNAMQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRR---EPIV 164
E L L+ K VLI+RG+GGRE AE+ ++ GA++ +V YRR EP +
Sbjct: 128 ESLFASIEAAFGGAAALAGKRVLIVRGDGGREWLAERLREAGADITLVAAYRRVVPEPRI 187
Query: 165 YNNAEQTSICKRAGIQTIVVTSAEILTQLVDFVPQN----EHNWLKSCQLITVSERIAHL 220
E+ +VTS+E + L + + E + LK L+T RI
Sbjct: 188 -GAWERVHALLGGEPHAWLVTSSEGVRNLHELARTHLNGAEIDALKHAPLVTPHARIEQT 246
Query: 221 AEALGWQNVVISPRADNQTL 240
A ALG+ + ++ D + +
Sbjct: 247 ARALGFDRITLTGAGDERIV 266
>gi|50083561|ref|YP_045071.1| uroporphyrinogen-III synthase (UROS) (Uroporphyrinogen-III
cosynthetase) (Hydroxymethylbilane hydrolyase
[cyclizing]) [Acinetobacter sp. ADP1]
gi|49529537|emb|CAG67249.1| uroporphyrinogen-III synthase (UROS) (Uroporphyrinogen-III
cosynthetase) (Hydroxymethylbilane hydrolyase
[cyclizing]) [Acinetobacter sp. ADP1]
Length = 256
Score = 59.3 bits (142), Expect = 2e-07, Method: Composition-based stats.
Identities = 58/219 (26%), Positives = 94/219 (42%), Gaps = 25/219 (11%)
Query: 1 MAVLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVS 60
M ++ TRP +R +L ++ G +LPL ++ L + +L + VS
Sbjct: 1 MLLINTRPADRADELTQAVSAQGYRVENLPLLVLKKKPFSAHLKQLYQQLDQSQLIVVVS 60
Query: 61 KSAVDFAFKTLTATGFVWRHDLH--YFTVGQGTA---QYFTATTEMPVHYPTAQENSEGL 115
+AV+ + L H + VG+ TA QY+ + E+P E SEG+
Sbjct: 61 PTAVEIGMQYLQKANISLSSLSHIRWVAVGKSTAKALQYYGISAEIP-----QVETSEGM 115
Query: 116 LQLNAMQDL-SDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSIC 174
LQL Q L S + V RG GGR+L +Q +G ++ Y R+ C
Sbjct: 116 LQLPVFQMLKSFRQVAFWRGEGGRQLMMQQLIDQGVHLLNFILYDRQ------------C 163
Query: 175 KRAGIQTIVVTSAEIL--TQLVDFVPQNEHNWLKSCQLI 211
+ Q I+ + +I+ Q V + +E +WL LI
Sbjct: 164 PESATQKILSIAHDIVQDKQPVWVLITSEASWLNWLSLI 202
>gi|134094242|ref|YP_001099317.1| uroporphyrinogen III synthase [Herminiimonas arsenicoxydans]
gi|133738145|emb|CAL61190.1| uroporphyrinogen III synthase [Herminiimonas arsenicoxydans]
Length = 260
Score = 58.9 bits (141), Expect = 3e-07, Method: Composition-based stats.
Identities = 69/250 (27%), Positives = 110/250 (44%), Gaps = 17/250 (6%)
Query: 3 VLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVSKS 62
V++TRP + + L + G A PL I A+ L L + VS +
Sbjct: 9 VVITRPLAQAEGLARRVTALGRKATVFPLLDILPLADQASLQQALRDLSGYALIAFVSPN 68
Query: 63 AVDFAFKTLTATGFVWRHDLHYFTVGQGT----AQYFTATTEMPVHYPTA--QENSEGLL 116
A+D A W D+ VG+G+ A++ + PT + +SE LL
Sbjct: 69 AIDAALAARAD----WPRDIPMAVVGEGSRLALARHGLTAENSTIISPTDLDRTDSETLL 124
Query: 117 QLNAMQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKR 176
+ L +K +LI+RG GR L +E + GA V ++ YRR V++ + + KR
Sbjct: 125 AELDLPALRNKQILIVRGETGRPLLSEALRAAGAQVTLLAAYRRVAPVFDATRRREL-KR 183
Query: 177 A--GIQTIVVTSAEILTQLVDFVPQ-NEHNWLKSCQ---LITVSERIAHLAEALGWQNVV 230
G +VTS+E L L+ V Q +E + Q +I RI A+ LG+ N+
Sbjct: 184 LLHGQNDWIVTSSEALRFLMQMVAQLDEAEGVAKMQQQRIIVSHIRIGETAQLLGFSNIT 243
Query: 231 ISPRADNQTL 240
++ D+ L
Sbjct: 244 VTRSGDDGLL 253
>gi|118707285|ref|ZP_01559871.1| protein of unknown function DUF513, hemX [Burkholderia cenocepacia
MC0-3]
gi|118654948|gb|EAV61727.1| protein of unknown function DUF513, hemX [Burkholderia cenocepacia
MC0-3]
Length = 656
Score = 58.5 bits (140), Expect = 4e-07, Method: Composition-based stats.
Identities = 76/260 (29%), Positives = 112/260 (43%), Gaps = 27/260 (10%)
Query: 4 LVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVSKSA 63
++TRPD + L LA AG + PL I + L FA L + V VS +A
Sbjct: 11 VLTRPDGQSDALAAQLADAGCDVLEFPLIDIAPVDDPAPLDAAFAALADYALVIFVSPNA 70
Query: 64 VDFAFKTLTATGFVWRHDLHYFTVGQGT-AQYFTATTEMPVHYPTAQE----------NS 112
+D A A +W + L VG G+ A P H A + +S
Sbjct: 71 IDRALARYDA---IWPNALPVGVVGPGSVAALERHGIAAPAHRVIAPQAPADGGVPHYDS 127
Query: 113 EGL-----LQLNAMQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRR---EPIV 164
E L + Q L+ K VLI+RG+GGRE AE+ ++ GA+V +V YRR EP V
Sbjct: 128 ESLFASIEVAFGGAQALAGKRVLIVRGDGGREWLAERLREAGADVTLVAAYRRVVPEPRV 187
Query: 165 YNNAEQTSICKRAGIQTIVVTSAEILTQLVDFVPQN----EHNWLKSCQLITVSERIAHL 220
E+ +VTS+E + L + + E + LK L+T RI
Sbjct: 188 -GAWERVHALLDGQPHGWLVTSSEGVRNLHELARAHLNDAEIDALKHAPLVTPHPRIEQT 246
Query: 221 AEALGWQNVVISPRADNQTL 240
A LG+ + ++ D + +
Sbjct: 247 ARTLGFDRITLTGAGDERIV 266
>gi|116750622|ref|YP_847309.1| uroporphyrin-III C-methyltransferase [Syntrophobacter fumaroxidans
MPOB]
gi|116699686|gb|ABK18874.1| uroporphyrin-III C-methyltransferase [Syntrophobacter fumaroxidans
MPOB]
Length = 519
Score = 57.0 bits (136), Expect = 1e-06, Method: Composition-based stats.
Identities = 49/201 (24%), Positives = 80/201 (39%), Gaps = 3/201 (1%)
Query: 3 VLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVSKS 62
++VTR E+ ML + G I P IE EL +L + D+ S +
Sbjct: 256 IVVTRAREQASDFKGMLTELGAHCIEFPTIAIEPPPSWRELDEAIRRLASYDWAIFTSVN 315
Query: 63 AVDFAFKTLTATGFVWRH--DLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNA 120
V F + L A G R + +G TA+ T + V ++ +E +L
Sbjct: 316 GVRFFMERLRALGLDVRELKGVRLAAIGPKTAEALEKTG-LRVDLVPSEYRAESILDSLG 374
Query: 121 MQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRAGIQ 180
DL ++ LI R R++ E + +GA VE+V YR E ++A I
Sbjct: 375 DADLRERRFLIPRAMVARDILPETLRAKGALVEVVPAYRTVIPRERGPEIAERFRKAEIH 434
Query: 181 TIVVTSAEILTQLVDFVPQNE 201
+ TS+ ++ + E
Sbjct: 435 CLTFTSSSTVSNFFSLFDRGE 455
>gi|118444865|ref|YP_878762.1| uroporphyrinogen III synthase/methyltransferase [Clostridium novyi
NT]
gi|118135321|gb|ABK62365.1| uroporphyrinogen III synthase/methyltransferase [Clostridium novyi
NT]
Length = 497
Score = 56.6 bits (135), Expect = 1e-06, Method: Composition-based stats.
Identities = 50/215 (23%), Positives = 98/215 (45%), Gaps = 8/215 (3%)
Query: 3 VLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVSKS 62
++VTR + LVD + G I +P +IE E +EL + ++ Y+ S++
Sbjct: 254 IVVTRARAQSSTLVDKIDSLGGNPIEIPSIKIEEILERDELIEEIKNIEKYSYLIFTSRN 313
Query: 63 AVDFAFKTLTATGFVWRH--DLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNA 120
AV+ F+ L GF R +L ++G GT++ + P + +E +++ +
Sbjct: 314 AVNIFFENLFKLGFDSRKLGNLKIVSIGNGTSEELKNKGIVADIVPK-RFVAESIVE--S 370
Query: 121 MQDL--SDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRAG 178
++D+ D +LI R RE + Q + NV+ V+ Y + N ++
Sbjct: 371 LKDILSKDDKILIPRAKESRE-YLTQELSKLCNVKEVKIYETIKMQNNKEYVLNLLDSDA 429
Query: 179 IQTIVVTSAEILTQLVDFVPQNEHNWLKSCQLITV 213
I I TS+ + +D + + + LK +L+++
Sbjct: 430 IDYITFTSSSTVKNFIDIIGKENIDKLKGTKLVSI 464
>gi|28198963|ref|NP_779277.1| uroporphyrinogen-III synthetase [Xylella fastidiosa Temecula1]
gi|28057061|gb|AAO28926.1| uroporphyrinogen-III synthase [Xylella fastidiosa Temecula1]
Length = 257
Score = 56.6 bits (135), Expect = 1e-06, Method: Composition-based stats.
Identities = 51/164 (31%), Positives = 79/164 (48%), Gaps = 10/164 (6%)
Query: 67 AFKTL-TATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNAMQDLS 125
A +TL T+ G VW VG TA+ V +PT Q NSEGLL L A Q +
Sbjct: 78 ALQTLRTSPGQVW------LCVGASTARVLQQCGITRVLHPT-QMNSEGLLTLLAQQPPT 130
Query: 126 DKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRAGIQTIVVT 185
+ V ++ GGR+L ++ + G + + Y R+P+ A ++ + A + ++
Sbjct: 131 E--VGLITAPGGRDLLQQKLLENGIRLHRADVYERQPLRLRTATLDTLQRNATRSLLALS 188
Query: 186 SAEILTQLVDFVPQNEHNWLKSCQLITVSERIAHLAEALGWQNV 229
SAE L L+ P N L +I S+R+ LA A G+ +V
Sbjct: 189 SAEALALLLPQWPDNLRRILYQRPVIATSKRLEDLACARGFISV 232
>gi|15838399|ref|NP_299087.1| uroporphyrinogen-III synthetase [Xylella fastidiosa 9a5c]
gi|9106876|gb|AAF84607.1|AE004001_12 uroporphyrinogen-III synthase [Xylella fastidiosa 9a5c]
Length = 305
Score = 55.5 bits (132), Expect = 3e-06, Method: Composition-based stats.
Identities = 51/164 (31%), Positives = 77/164 (46%), Gaps = 10/164 (6%)
Query: 67 AFKTLTAT-GFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNAMQDLS 125
A +TL A+ G VW VG TA+ V +PT Q NSEGLL L A Q +
Sbjct: 126 ALQTLRASPGQVW------LCVGASTARMLQQCGITRVLHPT-QMNSEGLLTLLAQQPPT 178
Query: 126 DKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRAGIQTIVVT 185
+ V ++ GGR+L ++ + G + Y R+P+ A + + A + ++
Sbjct: 179 E--VGLITAPGGRDLLQQKLLENGIRLHRANVYERQPLRLRTATLDVLQRNATRSMLALS 236
Query: 186 SAEILTQLVDFVPQNEHNWLKSCQLITVSERIAHLAEALGWQNV 229
SAE L L+ P N L +I S+R+ LA A G+ +V
Sbjct: 237 SAEALALLLPQWPDNLRRILYQRPVIATSKRLEDLACARGFISV 280
>gi|111019044|ref|YP_702016.1| probable uroporphiryn-III C-methyltransferase [Rhodococcus sp.
RHA1]
gi|110818574|gb|ABG93858.1| probable uroporphiryn-III C-methyltransferase [Rhodococcus sp.
RHA1]
Length = 521
Score = 55.1 bits (131), Expect = 4e-06, Method: Composition-based stats.
Identities = 52/213 (24%), Positives = 88/213 (41%), Gaps = 7/213 (3%)
Query: 3 VLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAV--S 60
VLV R ++ ++ D L G + I +P +E ++ L +G Y + V S
Sbjct: 253 VLVPRTKDQAGEMSDRLVTHGAIPIEVPTIAVEPPRSPAQMERSVKGLVDGRYQWVVFTS 312
Query: 61 KSAVDFAFKTLTATGFVWR--HDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLL-Q 117
+AV ++ G R + +G+ TA + P P+ +++SEGLL +
Sbjct: 313 TNAVRAVWEKFEEFGLDARAFSGVKIACIGEATAAKVRSFGINPELVPSGEQSSEGLLAE 372
Query: 118 LNAMQDLSDKT--VLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICK 175
D+ D VL+ R + E AE ++RG ++ V YR AE + K
Sbjct: 373 FAPYDDVFDPVNRVLLPRADIATETLAEGLRERGWEIDDVTAYRTVRAAPPPAETREMIK 432
Query: 176 RAGIQTIVVTSAEILTQLVDFVPQNEHNWLKSC 208
G + TS+ + LV + L +C
Sbjct: 433 TGGFDAVCFTSSSTVRNLVGIAGKPHARTLVAC 465
>gi|120401861|ref|YP_951690.1| Uroporphyrinogen III synthase HEM4 [Mycobacterium vanbaalenii
PYR-1]
gi|119954679|gb|ABM11684.1| Uroporphyrinogen III synthase HEM4 [Mycobacterium vanbaalenii
PYR-1]
Length = 571
Score = 55.1 bits (131), Expect = 4e-06, Method: Composition-based stats.
Identities = 52/199 (26%), Positives = 84/199 (42%), Gaps = 7/199 (3%)
Query: 3 VLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAV--S 60
VLV R ++ ++ D L G + I +P +E ++ L +G + + V S
Sbjct: 304 VLVPRTKDQAGEMSDRLVGHGALPIEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTS 363
Query: 61 KSAVDFAFKTLTATGFVWR--HDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLL-Q 117
+AV ++ G R + VGQ TA+ A P PT +++S GLL +
Sbjct: 364 TNAVRAVWEKFNEFGLDARAFSGVKIACVGQATAERVRAFGINPELVPTGEQSSLGLLDE 423
Query: 118 LNAMQDLSDKT--VLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICK 175
D+ D VL+ R + E AE ++RG +E V YR A+ + K
Sbjct: 424 FPPYDDIFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPAQTREMIK 483
Query: 176 RAGIQTIVVTSAEILTQLV 194
G + TS+ + LV
Sbjct: 484 TGGFDAVCFTSSSTVRNLV 502
>gi|71898564|ref|ZP_00680735.1| Uroporphyrinogen III synthase HEM4 [Xylella fastidiosa Ann-1]
gi|71731688|gb|EAO33748.1| Uroporphyrinogen III synthase HEM4 [Xylella fastidiosa Ann-1]
Length = 305
Score = 54.7 bits (130), Expect = 4e-06, Method: Composition-based stats.
Identities = 50/164 (30%), Positives = 78/164 (47%), Gaps = 10/164 (6%)
Query: 67 AFKTL-TATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNAMQDLS 125
A +TL T+ G VW VG TA+ V +PT Q NSEGLL L A Q +
Sbjct: 126 ALQTLRTSPGQVW------LCVGASTARVLQQCGITRVLHPT-QMNSEGLLTLLAQQPPT 178
Query: 126 DKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRAGIQTIVVT 185
+ V ++ GGR+L ++ + + + Y R+P+ A ++ + A + ++
Sbjct: 179 E--VGLITAPGGRDLLQQKLLENSIRLHRADVYERQPLRLRTATLDALQRNATRSLLALS 236
Query: 186 SAEILTQLVDFVPQNEHNWLKSCQLITVSERIAHLAEALGWQNV 229
SAE L L+ P N L +I S+R+ LA A G+ +V
Sbjct: 237 SAEALALLLPQWPDNLRRILYQRPVIATSKRLEDLACARGFISV 280
>gi|116622287|ref|YP_824443.1| uroporphyrin-III C-methyltransferase [Solibacter usitatus
Ellin6076]
gi|116225449|gb|ABJ84158.1| uroporphyrin-III C-methyltransferase [Solibacter usitatus
Ellin6076]
Length = 494
Score = 54.7 bits (130), Expect = 5e-06, Method: Composition-based stats.
Identities = 47/162 (29%), Positives = 70/162 (43%), Gaps = 14/162 (8%)
Query: 3 VLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAVSKS 62
++VTR E+ L L+ G I LP I A+ L A+L+ D++ S +
Sbjct: 248 IVVTRAREQADALGAALSSLGAGVIELPTIEIGPAADSGPLERAIAELETYDWLIFTSAN 307
Query: 63 AVDFAFKTLTATGFVWRHDLHYF-----TVGQGTAQYFTATTEMPVHYPTAQENSEGLLQ 117
V F + L DL +G T A + V + +EGLL+
Sbjct: 308 GVRFFVERLD--------DLRKLRSKICAIGPATRAAVEAL-HVKVDLMGKEYVAEGLLE 358
Query: 118 LNAMQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYR 159
A DL+ K VL+ R R+L + +RGA V++VE YR
Sbjct: 359 AFAAHDLAGKRVLLPRAAVARDLVPVELAKRGAQVDVVEAYR 400
>gi|88792783|ref|ZP_01108501.1| uroporphyrinogen-III synthetase [Alteromonas macleodii 'Deep
ecotype']
gi|88775833|gb|EAR07080.1| uroporphyrinogen-III synthetase [Alteromonas macleodii 'Deep
ecotype']
Length = 243
Score = 54.7 bits (130), Expect = 5e-06, Method: Composition-based stats.
Identities = 38/130 (29%), Positives = 65/130 (50%), Gaps = 6/130 (4%)
Query: 112 SEGLLQLNAMQDLSDKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQT 171
SEG+L ++ + + + + V+I++G GGR+ A ++G +V Y+REP+ T
Sbjct: 111 SEGILAMHQLNEANCQQVVIIKGEGGRDAIANGLDEKGMSVNSFCVYKREPL--TRPIYT 168
Query: 172 SICKRAGIQTIVVTSAEILTQLVDFVPQNEHNWLKSCQLITVSERIAHLAEALGWQNVVI 231
K + I+ TS + QL+ + N L + +TVS RIA G + V +
Sbjct: 169 KRWKLGEVSGIIATSEAMALQLI----EQFGNALLAYPWLTVSSRIAKTLTNKGIEEVAV 224
Query: 232 SPRADNQTLL 241
RA +Q L+
Sbjct: 225 CQRATDQALI 234
>gi|71275392|ref|ZP_00651678.1| Uroporphyrinogen III synthase HEM4 [Xylella fastidiosa Dixon]
gi|71163692|gb|EAO13408.1| Uroporphyrinogen III synthase HEM4 [Xylella fastidiosa Dixon]
Length = 305
Score = 54.7 bits (130), Expect = 5e-06, Method: Composition-based stats.
Identities = 50/164 (30%), Positives = 78/164 (47%), Gaps = 10/164 (6%)
Query: 67 AFKTL-TATGFVWRHDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLLQLNAMQDLS 125
A +TL T+ G VW VG TA+ V +PT Q NSEGLL L A Q +
Sbjct: 126 ALQTLRTSPGQVW------LCVGASTARVLQQCGITRVLHPT-QMNSEGLLTLLAQQPPT 178
Query: 126 DKTVLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRAGIQTIVVT 185
+ V ++ GGR+L ++ + + + Y R+P+ A ++ + A + ++
Sbjct: 179 E--VGLITAPGGRDLLQQKLLENSIRLHRADVYERQPLRLRTATLDALQRNATRSLLALS 236
Query: 186 SAEILTQLVDFVPQNEHNWLKSCQLITVSERIAHLAEALGWQNV 229
SAE L L+ P N L +I S+R+ LA A G+ +V
Sbjct: 237 SAEALALLLPQWPDNLRRILYQRPVIATSKRLEDLACARGFISV 280
>gi|90023306|ref|YP_529133.1| Na+/H+ antiporter NhaA [Saccharophagus degradans 2-40]
gi|89952906|gb|ABD82921.1| Uroporphyrinogen III synthase HEM4 [Saccharophagus degradans 2-40]
Length = 290
Score = 54.3 bits (129), Expect = 6e-06, Method: Composition-based stats.
Identities = 59/248 (23%), Positives = 104/248 (41%), Gaps = 32/248 (12%)
Query: 26 AIHLPLFRI---ESGAELNELPNKFAKLKNGDYVFAVSKSAVDFAFKTLTATGFVWRHDL 82
A+ +PL I AE +L + L + + VS++AV+ F L L
Sbjct: 37 ALPIPLLEIIPVTGEAEKRQLQTQALGLDDYQKILFVSQNAVEHFFTCLEDYWPQLPKQL 96
Query: 83 HYFTVGQGTAQ-------YFTATTEMPVHYPTAQENSEGLLQLNAMQDLSDKTVLILRGN 135
+ VG+ T Q + + V NSE LL + +Q + + +LI RG
Sbjct: 97 CFIGVGEKTKQAILQQLDRWGCAGDQIVLGGVDAMNSEALLAMPELQQVDAEKILICRGV 156
Query: 136 GGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICKRAGIQTIV----VTSAEILT 191
GGR + E RGA +E E Y+R + ++ A + + V S E LT
Sbjct: 157 GGRPMLGEILVARGARIEYCELYQRAL----PKQAVAVLAEADLNSTTDICPVFSGETLT 212
Query: 192 QLVDFVPQNEH-------------NWLKSCQLITVSERIAHLAEALGWQNVVISPRADNQ 238
LV + ++ + W ++ ++ ER+A A+A+G++ + ++ A
Sbjct: 213 NLVAVLAKHSNPRASEKPPFRLPAQW-RALIVVVPGERVAQHAKAVGFKRIAVAKNATEP 271
Query: 239 TLLQTLLQ 246
+L+ + Q
Sbjct: 272 AMLKAIQQ 279
>gi|108797658|ref|YP_637855.1| Uroporphyrinogen III synthase HEM4 [Mycobacterium sp. MCS]
gi|119866745|ref|YP_936697.1| Uroporphyrinogen III synthase HEM4 [Mycobacterium sp. KMS]
gi|108768077|gb|ABG06799.1| Uroporphyrinogen III synthase HEM4 [Mycobacterium sp. MCS]
gi|119692834|gb|ABL89907.1| Uroporphyrinogen III synthase HEM4 [Mycobacterium sp. KMS]
Length = 554
Score = 54.3 bits (129), Expect = 7e-06, Method: Composition-based stats.
Identities = 52/199 (26%), Positives = 83/199 (41%), Gaps = 7/199 (3%)
Query: 3 VLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAV--S 60
VLV R ++ ++ D L G + I +P +E ++ L +G + + V S
Sbjct: 287 VLVPRTKDQAGEMSDKLVGHGALPIEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTS 346
Query: 61 KSAVDFAFKTLTATGFVWR--HDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLL-Q 117
+AV ++ G R + VGQ TA+ A P PT +++S GLL +
Sbjct: 347 TNAVRAVWEKFNEFGLDARAFSGVKIACVGQATAERVRAFGINPELVPTGEQSSLGLLDE 406
Query: 118 LNAMQDLSDKT--VLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICK 175
D+ D VL+ R + E AE ++RG +E V YR A + K
Sbjct: 407 FPPYDDIFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPASTREMIK 466
Query: 176 RAGIQTIVVTSAEILTQLV 194
G + TS+ + LV
Sbjct: 467 TGGFDAVCFTSSSTVRNLV 485
>gi|126433282|ref|YP_001068973.1| Uroporphyrinogen III synthase HEM4 [Mycobacterium sp. JLS]
gi|126233082|gb|ABN96482.1| Uroporphyrinogen III synthase HEM4 [Mycobacterium sp. JLS]
Length = 554
Score = 54.3 bits (129), Expect = 7e-06, Method: Composition-based stats.
Identities = 52/199 (26%), Positives = 83/199 (41%), Gaps = 7/199 (3%)
Query: 3 VLVTRPDERGQQLVDMLAKAGVVAIHLPLFRIESGAELNELPNKFAKLKNGDYVFAV--S 60
VLV R ++ ++ D L G + I +P +E ++ L +G + + V S
Sbjct: 287 VLVPRTKDQAGEMSDKLVGHGALPIEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTS 346
Query: 61 KSAVDFAFKTLTATGFVWR--HDLHYFTVGQGTAQYFTATTEMPVHYPTAQENSEGLL-Q 117
+AV ++ G R + VGQ TA+ A P PT +++S GLL +
Sbjct: 347 TNAVRAVWEKFNEFGLDARAFSGVKIACVGQATAERVRAFGINPELVPTGEQSSLGLLDE 406
Query: 118 LNAMQDLSDKT--VLILRGNGGRELFAEQAQQRGANVEIVECYRREPIVYNNAEQTSICK 175
D+ D VL+ R + E AE ++RG +E V YR A + K
Sbjct: 407 FPPYDDIFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPASTREMIK 466
Query: 176 RAGIQTIVVTSAEILTQLV 194
G + TS+ + LV
Sbjct: 467 TGGFDAVCFTSSSTVRNLV 485
Database: nr
Posted date: Sep 17, 2007 11:41 AM
Number of letters in database: 999,999,834
Number of sequences in database: 2,976,859
Database: /nucleus1/users/jsaw/ncbi/db/nr.01
Posted date: Sep 17, 2007 11:48 AM
Number of letters in database: 894,087,890
Number of sequences in database: 2,493,262
Lambda K H
0.320 0.133 0.387
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 843,715,517
Number of Sequences: 5470121
Number of extensions: 31866821
Number of successful extensions: 96244
Number of sequences better than 1.0e-05: 221
Number of HSP's better than 0.0 without gapping: 113
Number of HSP's successfully gapped in prelim test: 108
Number of HSP's that attempted gapping in prelim test: 95815
Number of HSP's gapped (non-prelim): 233
length of query: 248
length of database: 1,894,087,724
effective HSP length: 129
effective length of query: 119
effective length of database: 1,188,442,115
effective search space: 141424611685
effective search space used: 141424611685
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 128 (53.9 bits)