Genomics on the ISS: Recommendations: Model Organisms

Workshop Recommendations

Ecological Systems

Workshop Presentations

Genomic Studies of Renal Cells in Space

Technologies

Available Hardware

Recommendations
Model Organisms

Questions	Prokaryotes	Eucaryotes
1. Mechanisms of mutation	E. coli B. subtilis Deinococcus radiodurans	Yeast C. elegans Arabidopsis seeds robust embyos Drosphila
2. cell-cell interaction a. colony morphology (prokayrotes	E. coli B. subtilis	Dictyostelium cell lines fungi hydra volvox
3. cell-substrate interaction	all biofilms	Dictyostelium cell lines plant callus cultures
4. motility a. gliding b. flagellate	many flagellates	ciliates flagellates amoebae cell lines
5. cell morphology: intracellular vs. overall cell type	B. subtilis (rods/spheres)	euglenoids cell lines
6. development	B. subtilis Calobacter c. Synechococcus (sp?)	cell lines Dictyostelium C. elegans fungi
7. stress/stimulus response
a. gravity	???????	plants (moss/algae) euglenoids osteoblasts paramecia/ciliates
b. radiation c. physical (surface tension etc. in culture environment d. provocative stimuli (heat, pharmacological agents)	Wide range	Wide range
8. cell cycle/ growth rate cessation of growth	E. coli	yeast cell lines ciliates Drosophila C. elegans
9. sex	E. coli conjugation and other gene transfer between prokaryotes	yeast ciliates
10. phage/virus Structure/assembly Interaction with cell surface Reactivation of latency	lysogenic/lytic	cell cultures
11. selection (loss of function)	bacteriophage E. coli prokaryotes with fast doubling times	yeast C. elegans?
12. photosynthesis	cyanobacter rhodobacteria
13. health	crew microbial flora spacecraft microbial flora

Responsible NASA Officials:
Lynn Harper and Greg Schmidt

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Symtech Corp.