The Joshua Lederberg Papers

Title:

Letter from Joshua Lederberg to Ralph Steinman

Description:

Item is handwritten. Item is a photocopy.

Number of Image Pages:

1 (47,482 Bytes)

Date:

1988-05-05 (May 5, 1988)

Creator:

Lederberg, Joshua

Recipient:

Steinman, Ralph

Rights:

This item is in the public domain. It may be used without permission.

Relation:

Lederberg Grouping: Correspondence F

Box Number: 39

Folder Number: 11 & 12

Unique Identifier:

BBAQLT

Accession Number:

Document Type:

Letters (correspondence)

Language:

English

Format:

application/pdf

image/tif

Physical Condition:

Good

Series: Correspondence, 1935-2002

SubSeries: 1985-1999

Folder: AIDS

Transcript:

Ralph Steinman

5/5/88

Dear Ralph:

Activation of AIDS: by AZT?

The thought has concerned me for some time that Xray, cytoxic chemicals are good candidates for the activation of a latent virus -- as they do in bacterial prophage . . .

The worse thought arises that AZT might also do just that, albeit it inhibits the replication of the virus as well.

Do you know of any way in which this possibility has been tested -- with animal cells? with lysogenic bacteria?

Joshua.

Metadata Last Modified Date:

2007-01-12

Annotation by Joshua Lederberg:

KW: handwritten; could latent HIV be activated by AZT?  Compare lysogenic
bacteria;

jl  10/18/99

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