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Title Effects of whole-body and partial-body x irradiation upon epidermal mitotic activity during wound healing in mouse skin
Creator/Author Kobayashi, K.
Publication Date1977 Mar 01
OSTI IdentifierOSTI ID: 7215293
Other Number(s)CODEN: RAREA
Resource TypeJournal Article
Resource RelationRadiat. Res. ; Vol/Issue: 69:3
Research OrgMisaki Marine Biological Station, Japan
Subject560152 -- Radiation Effects on Animals-- Animals; ;EPIDERMIS-- BIOLOGICAL RADIATION EFFECTS;EPIDERMIS-- MITOSIS;SKIN-- BIOLOGICAL RADIATION EFFECTS;WOUNDS-- HEALING; MICE;PARTIAL BODY IRRADIATION;WHOLE-BODY IRRADIATION;X RADIATION
Related SubjectANIMALS;BIOLOGICAL EFFECTS;BIOLOGICAL RECOVERY;BODY;CELL DIVISION;ELECTROMAGNETIC RADIATION;EPITHELIUM;EXTERNAL IRRADIATION;INJURIES;IONIZING RADIATIONS;IRRADIATION;MAMMALS;ORGANS;RADIATION EFFECTS;RADIATIONS;RECOVERY;RODENTS;SKIN;TISSUES;VERTEBRATES
Description/Abstract Mitotic activity of normal (unwounded) and wounded skin was measured in the control (nonirradiated) and whole-body or partial-body x-irradiated mouse.^Higher mitotic activity in the anterior than in the posterior region of the body was found in both the normal and the wounded skin of the control mouse.^Whole-body irradiation (500 R) depressed completely the mitotic activity of normal skin 2 to 4 days after irradiation.^In spite of this depression in mitotic activity, a surgical incision made 1 to 3 days after irradiation could induce a burst of proliferation after an inhibition of an initial mitosis increase.^When the animals were partially irradiated with 500 R 3 days before wounding, it was shown that mitosis at 24 hr after wounding was inhibited markedly by the local effect of irradiation and that mitosis also could be inhibited diversely by the abscopal effect of irradiation.^Because of a close similarity of sequential mitotic patterns between whole-body-irradiated and flapped-skin-only-irradiated groups (direct irradiation), the effect of irradiation upon mitosis was considered to be primarily local.^Some discussions were made concerning the possible reasons which made a difference in mitotic patterns between the head-only-irradiated group, the irradiated group including the head and other parts of the body except for the skin flap (abscopal irradiation).
Country of PublicationUnited States
LanguageEnglish
FormatPages: 513-529
System Entry Date2001 May 13

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