catalytic activity:ATP + a protein = ADP + a phosphoprotein.,
cofactor:Magnesium.,
enzyme regulation:Activated by phosphorylation on Thr-208 by STK11 in complex with STE20-related adapter-alpha (STRAD alpha) pseudo kinase and CAB39.,
function:Role in epithelial morphogenesis. Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells. May play a role in hormone secretion in the pituitary and/or the hypothalamus.,
similarity:Belongs to the protein kinase superfamily.,
similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. MARK subfamily.,
similarity:Contains 1 KA1 (kinase-associated) domain.,
similarity:Contains 1 UBA domain.,
similarity:Contains 1 protein kinase domain.,
subcellular location:Cell membrane; Peripheral membrane protein (By similarity). Note=Phosphorylated by PRKCZ in polarized epithelial cells, resulting in an interaction with Ywhaz which promotes relocation from the lateral to the apical membrane.,
tissue specificity:Highly expressed in adult kidney and testis, lower levels in heart, brain, spleen, lung and liver. Expressed in the head and neural fold in 8 dpc embryos, the limb buds, telencephalic vesicles, eyes, branchial archs and heart at 11.5 dpc, the ectoderm at 13 dpc and epiderm, hair and whisker follicles at 15 dpc.,
Role in epithelial morphogenesis. Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells. May play a role in hormone secretion in the pituitary and/or the hypothalamus.,
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