Arendt G, Hefter H, von Giesen HJ, Nelles HW, Jablonowski H; International Conference on AIDS.
Int Conf AIDS. 1992 Jul 19-24; 8: B217 (abstract no. PoB 3760).
Dept. of Neurology, Univ. of Dusseldorf.
OBJECTIVES: The diagnostic value of event-related potentials (ERP) in evaluating cognitive decline in HIV-related cerebral dysfunction was examined. METHODS: Therefore 100 clinically asymptomatic HIV-positive patients without drug- or alcohol-abuse, opportunistic cerebral infections, seizures and CMV-retinitis, but with normal MRI-scans and 33 demented HIV-positive individuals were tested with an ERP auditory oddball paradigm in comparison to an age- and sex-matched control population. Evaluated were: N1, P2, N2 and P3-latencies, N1-P2, P2-N2 and N2-P3 amplitudes and amplitude mapping. ERP results of the patient groups were correlated with test-psychometrical performances and standard EEG-recordings. RESULTS: Whereas the asymptomatic population showed statistically significant amplitude reductions and -distributions in comparison to the control population and additionally, an acceleration of physiological amplitude reduction with age. the demented group revealed prolonged latencies of the so-called "endogenous peaks" (N2 and P3) or completely abolished N2 and P3 peaks. Clinical signs of basal ganglia dysfunction (bradykinesia, hypomimia) and time-dependent test-psychometrical performances correlated with latency prolongations and a slowing of the EEG alpha-rhythm. CONCLUSIONS: The data suggest cortical and subcortical dysfunction in demented HIV-positives as well as primary subcortical deficits in clinically asymptomatic HIV-positive individuals detectable with electrophysiological methods which probably have a predictive value in HIV-related brain disease.
Publication Types:
Keywords:
- Acquired Immunodeficiency Syndrome
- Alcoholism
- Alpha Rhythm
- Alzheimer Disease
- Basal Ganglia
- Brain
- Brain Diseases
- Case-Control Studies
- Cytomegalovirus Retinitis
- Electroencephalography
- Evoked Potentials
- HIV Infections
- HIV Seropositivity
- Humans
- Magnetic Resonance Imaging
- diagnosis
Other ID:
UI: 102199200
From Meeting Abstracts